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1

Boon, Reinier A., Nicolas Jaé, Lesca Holdt, and Stefanie Dimmeler. "Long Noncoding RNAs." Journal of the American College of Cardiology 67, no. 10 (March 2016): 1214–26. http://dx.doi.org/10.1016/j.jacc.2015.12.051.

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2

Gough, N. R. "Painful Long Noncoding RNA." Science Signaling 6, no. 287 (August 6, 2013): ec181-ec181. http://dx.doi.org/10.1126/scisignal.2004591.

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3

Wu, Connie, and Pankaj Arora. "Long Noncoding Mhrt RNA." Circulation: Cardiovascular Genetics 8, no. 1 (February 2015): 213–15. http://dx.doi.org/10.1161/circgenetics.115.001019.

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4

Yoon, Je-Hyun, Jiyoung Kim, and Myriam Gorospe. "Long noncoding RNA turnover." Biochimie 117 (October 2015): 15–21. http://dx.doi.org/10.1016/j.biochi.2015.03.001.

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5

Wang, Yang-Ning-Zhi, Kun Shan, Mu-Di Yao, Jin Yao, Jia-Jian Wang, Xiang Li, Ban Liu, et al. "Long Noncoding RNA-GAS5." Hypertension 68, no. 3 (September 2016): 736–48. http://dx.doi.org/10.1161/hypertensionaha.116.07259.

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6

Zhang, Xu, and Wenqian Hu. "Long noncoding RNAs in hematopoiesis." F1000Research 5 (July 20, 2016): 1771. http://dx.doi.org/10.12688/f1000research.8349.1.

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Mammalian development is under tight control to ensure precise gene expression. Recent studies reveal a new layer of regulation of gene expression mediated by long noncoding RNAs. These transcripts are longer than 200nt that do not have functional protein coding capacity. Interestingly, many of these long noncoding RNAs are expressed with high specificity in different types of cells, tissues, and developmental stages in mammals, suggesting that they may have functional roles in diverse biological processes. Here, we summarize recent findings of long noncoding RNAs in hematopoiesis, which is one of the best-characterized mammalian cell differentiation processes. Then we provide our own perspectives on future studies of long noncoding RNAs in this field.
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7

Mueller, K. L. "Long noncoding RNAs in inflammation." Science 352, no. 6281 (March 31, 2016): 48–49. http://dx.doi.org/10.1126/science.352.6281.48-e.

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8

Zhang, Yang, Xiao-Ou Zhang, Tian Chen, Jian-Feng Xiang, Qing-Fei Yin, Yu-Hang Xing, Shanshan Zhu, Li Yang, and Ling-Ling Chen. "Circular Intronic Long Noncoding RNAs." Molecular Cell 51, no. 6 (September 2013): 792–806. http://dx.doi.org/10.1016/j.molcel.2013.08.017.

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9

Jian, Liguo, Dongdong Jian, Qishan Chen, and Li Zhang. "Long Noncoding RNAs in Atherosclerosis." Journal of Atherosclerosis and Thrombosis 23, no. 4 (2016): 376–84. http://dx.doi.org/10.5551/jat.33167.

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10

Atianand, Maninjay K., Daniel R. Caffrey, and Katherine A. Fitzgerald. "Immunobiology of Long Noncoding RNAs." Annual Review of Immunology 35, no. 1 (April 26, 2017): 177–98. http://dx.doi.org/10.1146/annurev-immunol-041015-055459.

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11

Carpenter, Susan, and Katherine A. Fitzgerald. "Cytokines and Long Noncoding RNAs." Cold Spring Harbor Perspectives in Biology 10, no. 6 (July 17, 2017): a028589. http://dx.doi.org/10.1101/cshperspect.a028589.

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12

Pandey, Gaurav Kumar, and Chandrasekhar Kanduri. "Long noncoding RNAs and neuroblastoma." Oncotarget 6, no. 21 (June 10, 2015): 18265–75. http://dx.doi.org/10.18632/oncotarget.4251.

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13

Wu, Connie, and Pankaj Arora. "Long Noncoding RNA–MicroRNA–mRNA." Circulation: Cardiovascular Genetics 7, no. 5 (October 2014): 729–31. http://dx.doi.org/10.1161/circgenetics.114.000866.

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14

Zhu, Shanshan, Xiao-Ou Zhang, and Li Yang. "Panning for Long Noncoding RNAs." Biomolecules 3, no. 4 (February 28, 2013): 226–41. http://dx.doi.org/10.3390/biom3010226.

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15

Gallagher, Patrick G. "Long noncoding RNAs in erythropoiesis." Blood 123, no. 4 (January 23, 2014): 465–66. http://dx.doi.org/10.1182/blood-2013-12-538306.

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16

Zampetaki, Anna, and Manuel Mayr. "Long Noncoding RNAs and Angiogenesis." Circulation 136, no. 1 (July 4, 2017): 80–82. http://dx.doi.org/10.1161/circulationaha.117.028398.

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17

Sun, Lei, Loyal A. Goff, Cole Trapnell, Ryan Alexander, Kinyui Alice Lo, Ezgi Hacisuleyman, Martin Sauvageau, et al. "Long noncoding RNAs regulate adipogenesis." Proceedings of the National Academy of Sciences 110, no. 9 (February 11, 2013): 3387–92. http://dx.doi.org/10.1073/pnas.1222643110.

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18

Zhou, Tian, Jia-wang Ding, Xin-An Wang, and Xia-xia Zheng. "Long noncoding RNAs and atherosclerosis." Atherosclerosis 248 (May 2016): 51–61. http://dx.doi.org/10.1016/j.atherosclerosis.2016.02.025.

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19

Zhang, Zhengyi, David Salisbury, and Tamer Sallam. "Long Noncoding RNAs in Atherosclerosis." Journal of the American College of Cardiology 72, no. 19 (November 2018): 2380–90. http://dx.doi.org/10.1016/j.jacc.2018.08.2161.

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20

Jiang, Shi-de, Jian Lu, Zhen-han Deng, Yu-sheng Li, and Guang-hua Lei. "Long noncoding RNAs in osteoarthritis." Joint Bone Spine 84, no. 5 (October 2017): 553–56. http://dx.doi.org/10.1016/j.jbspin.2016.09.006.

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21

Wierzbicki, Andrzej T., Todd Blevins, and Szymon Swiezewski. "Long Noncoding RNAs in Plants." Annual Review of Plant Biology 72, no. 1 (June 17, 2021): 245–71. http://dx.doi.org/10.1146/annurev-arplant-093020-035446.

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Plants have an extraordinary diversity of transcription machineries, including five nuclear DNA-dependent RNA polymerases. Four of these enzymes are dedicated to the production of long noncoding RNAs (lncRNAs), which are ribonucleic acids with functions independent of their protein-coding potential. lncRNAs display a broad range of lengths and structures, but they are distinct from the small RNA guides of RNA interference (RNAi) pathways. lncRNAs frequently serve as structural, catalytic, or regulatory molecules for gene expression. They can affect all elements of genes, including promoters, untranslated regions, exons, introns, and terminators, controlling gene expression at various levels, including modifying chromatin accessibility, transcription, splicing, and translation. Certain lncRNAs protect genome integrity, while others respond to environmental cues like temperature, drought, nutrients, and pathogens. In this review, we explain the challenge of defining lncRNAs, introduce the machineries responsible for their production, and organize this knowledge by viewing the functions of lncRNAs throughout the structure of a typical plant gene.
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22

Han, Siyu, Yanchun Liang, Ying Li, and Wei Du. "Long Noncoding RNA Identification: Comparing Machine Learning Based Tools for Long Noncoding Transcripts Discrimination." BioMed Research International 2016 (2016): 1–14. http://dx.doi.org/10.1155/2016/8496165.

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Long noncoding RNA (lncRNA) is a kind of noncoding RNA with length more than 200 nucleotides, which aroused interest of people in recent years. Lots of studies have confirmed that human genome contains many thousands of lncRNAs which exert great influence over some critical regulators of cellular process. With the advent of high-throughput sequencing technologies, a great quantity of sequences is waiting for exploitation. Thus, many programs are developed to distinguish differences between coding and long noncoding transcripts. Different programs are generally designed to be utilised under different circumstances and it is sensible and practical to select an appropriate method according to a certain situation. In this review, several popular methods and their advantages, disadvantages, and application scopes are summarised to assist people in employing a suitable method and obtaining a more reliable result.
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23

Losko, Magdalena, Jerzy Kotlinowski, and Jolanta Jura. "Long Noncoding RNAs in Metabolic Syndrome Related Disorders." Mediators of Inflammation 2016 (2016): 1–12. http://dx.doi.org/10.1155/2016/5365209.

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Ribonucleic acids (RNAs) are very complex and their all functions have yet to be fully clarified. Noncoding genes (noncoding RNA, sequences, and pseudogenes) comprise 67% of all genes and they are represented by housekeeping noncoding RNAs (transfer RNA (tRNA), ribosomal RNA (rRNA), small nuclear RNA (snRNA), and small nucleolar RNA (snoRNA)) that are engaged in basic cellular processes and by regulatory noncoding RNA (short and long noncoding RNA (ncRNA)) that are important for gene expression/transcript stability. In this review, we summarize data concerning the significance of long noncoding RNAs (lncRNAs) in metabolic syndrome related disorders, focusing on adipose tissue and pancreatic islands.
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24

He, Chunling, Xinmei Wang, Jing Luo, Yinghua Ma, and Zhen Yang. "Long Noncoding RNA Maternally Expressed Gene 3 Is Downregulated, and Its Insufficiency Correlates With Poor-Risk Stratification, Worse Treatment Response, as Well as Unfavorable Survival Data in Patients With Acute Myeloid Leukemia." Technology in Cancer Research & Treatment 19 (January 1, 2020): 153303382094581. http://dx.doi.org/10.1177/1533033820945815.

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Objective: Our study aimed to investigate the correlation of long noncoding RNA maternally expressed gene 3 expression with clinical features, treatment response, and survival profiles in patients with acute myeloid leukemia. Methods: Bone marrow samples of 122 de novo patients with acute myeloid leukemia (prior to treatment) and 30 healthy donors (after enrollment) were collected, and long noncoding RNA maternally expressed gene 3 expression was detected by reverse transcription quantitative polymerase chain reaction. According to median value of long noncoding RNA maternally expressed gene 3 expression in patients with acute myeloid leukemia, they were divided into long noncoding RNA maternally expressed gene 3 high expression and low expression patients (which were further categorized as low---, low--, and low- expression patients). Results: Long noncoding RNA maternally expressed gene 3 expression was decreased in patients with acute myeloid leukemia compared to healthy donors. Besides, receiver operating characteristic curve displayed that long noncoding RNA maternally expressed gene 3 distinguished patients with acute myeloid leukemia from healthy donors. In patients with acute myeloid leukemia, long noncoding RNA maternally expressed gene 3 low expression was associated with poor-risk stratification but was not correlated with age, gender, French-American-Britain classification, or white blood cell level. For prognosis, complete remission rate was lowest in long noncoding RNA maternally expressed gene 3 low--- expression patients, followed by long noncoding RNA maternally expressed gene 3 low-- expression patients, long noncoding RNA maternally expressed gene 3 low- expression patients, and was highest in long noncoding RNA maternally expressed gene 3 high expression patients; Kaplan-Meier curves displayed that lower long noncoding RNA maternally expressed gene 3 expression was associated with reduced event-free survival and overall survival; Cox regression analysis showed that lower long noncoding RNA maternally expressed gene 3 expression independently predicted decreased event-free survival and worse overall survival in patients with acute myeloid leukemia. Conclusion: Long noncoding RNA maternally expressed gene 3 may function as a novel marker for effective surveillance and management of acute myeloid leukemia.
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25

Novikova, Irina, Scott Hennelly, and Karissa Sanbonmatsu. "Tackling Structures of Long Noncoding RNAs." International Journal of Molecular Sciences 14, no. 12 (December 4, 2013): 23672–84. http://dx.doi.org/10.3390/ijms141223672.

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26

Liu, Xiaodong, Dan Shi, and Cheng Zhang. "Long noncoding RNAs in cervical cancer." Journal of Cancer Research and Therapeutics 14, no. 4 (2018): 745. http://dx.doi.org/10.4103/jcrt.jcrt_669_17.

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27

Hung, Tiffany, and Howard Y. Chang. "Long noncoding RNA in genome regulation." RNA Biology 7, no. 5 (September 2010): 582–85. http://dx.doi.org/10.4161/rna.7.5.13216.

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28

Maruyama, Reo, and Hiromu Suzuki. "Long noncoding RNA involvement in cancer." BMB Reports 45, no. 11 (November 30, 2012): 604–11. http://dx.doi.org/10.5483/bmbrep.2012.45.11.227.

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29

Wang, Kevin C., and Howard Y. Chang. "Molecular Mechanisms of Long Noncoding RNAs." Molecular Cell 43, no. 6 (September 2011): 904–14. http://dx.doi.org/10.1016/j.molcel.2011.08.018.

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30

Yin, Qing-Fei, Li Yang, Yang Zhang, Jian-Feng Xiang, Yue-Wei Wu, Gordon G. Carmichael, and Ling-Ling Chen. "Long Noncoding RNAs with snoRNA Ends." Molecular Cell 48, no. 2 (October 2012): 219–30. http://dx.doi.org/10.1016/j.molcel.2012.07.033.

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31

Haldar, Agnik, Sanga Mitra, and Jayprokas Chakrabarti. "Perspective on long noncoding RNA functionality." Translational Cancer Research 6, S6 (August 2017): S1049—S1053. http://dx.doi.org/10.21037/tcr.2017.07.20.

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32

CHEN, Jie, Cheng-jie ZHU, Yan SHANG, Chong BAI, and Qiang LI. "Long noncoding RNAs and lung cancer." Academic Journal of Second Military Medical University 35, no. 10 (2014): 1115. http://dx.doi.org/10.3724/sp.j.1008.2014.01115.

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33

Clark, Michael B., and John S. Mattick. "Long noncoding RNAs in cell biology." Seminars in Cell & Developmental Biology 22, no. 4 (June 2011): 366–76. http://dx.doi.org/10.1016/j.semcdb.2011.01.001.

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34

Fanelli, Giuseppe Nicolò, Pierluigi Gasparini, Irene Coati, Ri Cui, Hubert Pakula, Basudev Chowdhury, Nicola Valeri, et al. "LONG-NONCODING RNAs in gastroesophageal cancers." Non-coding RNA Research 3, no. 4 (December 2018): 195–212. http://dx.doi.org/10.1016/j.ncrna.2018.10.001.

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35

Fortes, Puri, and Kevin V. Morris. "Long noncoding RNAs in viral infections." Virus Research 212 (January 2016): 1–11. http://dx.doi.org/10.1016/j.virusres.2015.10.002.

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36

Lee, J. T. "Epigenetic Regulation by Long Noncoding RNAs." Science 338, no. 6113 (December 13, 2012): 1435–39. http://dx.doi.org/10.1126/science.1231776.

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37

Sedaghati, Mahsa, and Electron Kebebew. "Long noncoding RNAs in thyroid cancer." Current Opinion in Endocrinology & Diabetes and Obesity 26, no. 5 (October 2019): 275–81. http://dx.doi.org/10.1097/med.0000000000000497.

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38

Rayner, Katey J. "Leading the Long Noncoding RNA Pack." Arteriosclerosis, Thrombosis, and Vascular Biology 40, no. 3 (March 2020): 495–97. http://dx.doi.org/10.1161/atvbaha.119.313762.

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39

Liu, Jun, Huan Wang, and Nam-Hai Chua. "Long noncoding RNA transcriptome of plants." Plant Biotechnology Journal 13, no. 3 (January 23, 2015): 319–28. http://dx.doi.org/10.1111/pbi.12336.

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40

Alexanian, Michael, and Samir Ounzain. "Long Noncoding RNAs in Cardiac Development." Cold Spring Harbor Perspectives in Biology 12, no. 11 (January 13, 2020): a037374. http://dx.doi.org/10.1101/cshperspect.a037374.

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41

Nam, J. W., and D. P. Bartel. "Long noncoding RNAs in C. elegans." Genome Research 22, no. 12 (June 15, 2012): 2529–40. http://dx.doi.org/10.1101/gr.140475.112.

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42

Wapinski, Orly, and Howard Y. Chang. "Long noncoding RNAs and human disease." Trends in Cell Biology 21, no. 6 (June 2011): 354–61. http://dx.doi.org/10.1016/j.tcb.2011.04.001.

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43

Rosa, Alessandro, and Monica Ballarino. "Long Noncoding RNA Regulation of Pluripotency." Stem Cells International 2016 (2016): 1–9. http://dx.doi.org/10.1155/2016/1797692.

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Pluripotent stem cells (PSCs) represent a unique kind of stem cell, as they are able to indefinitely self-renew and hold the potential to differentiate into any derivative of the three germ layers. As such, human Embryonic Stem Cells (hESCs) and human induced Pluripotent Stem Cells (hiPSCs) provide a unique opportunity for studying the earliest steps of human embryogenesis and, at the same time, are of great therapeutic interest. The molecular mechanisms underlying pluripotency represent a major field of research. Recent evidence suggests that a complex network of transcription factors, chromatin regulators, and noncoding RNAs exist in pluripotent cells to regulate the balance between self-renewal and multilineage differentiation. Regulatory noncoding RNAs come in two flavors: short and long. The first class includes microRNAs (miRNAs), which are involved in the posttranscriptional regulation of cell cycle and differentiation in PSCs. Instead, long noncoding RNAs (lncRNAs) represent a heterogeneous group of long transcripts that regulate gene expression at transcriptional and posttranscriptional levels. In this review, we focus on the role played by lncRNAs in the maintenance of pluripotency, emphasizing the interplay between lncRNAs and other pivotal regulators in PSCs.
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44

Zhang, Yuan, and Xuetao Cao. "Long noncoding RNAs in innate immunity." Cellular & Molecular Immunology 13, no. 2 (August 17, 2015): 138–47. http://dx.doi.org/10.1038/cmi.2015.68.

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45

Rodríguez-Malavé, Norma I., and Dinesh S. Rao. "Long noncoding RNAs in hematopoietic malignancies." Briefings in Functional Genomics 15, no. 3 (November 26, 2015): 227–38. http://dx.doi.org/10.1093/bfgp/elv047.

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46

Drum, Chester L. "Long Noncoding RNAs in Myocardial Infarction." Science Translational Medicine 6, no. 247 (July 30, 2014): 247ec131. http://dx.doi.org/10.1126/scitranslmed.3009818.

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47

Jaé, Nicolas, and Stefanie Dimmeler. "Long Noncoding RNAs in Diabetic Retinopathy." Circulation Research 116, no. 7 (March 27, 2015): 1104–6. http://dx.doi.org/10.1161/circresaha.115.306051.

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48

Uchida, Shizuka, and Stefanie Dimmeler. "Long Noncoding RNAs in Cardiovascular Diseases." Circulation Research 116, no. 4 (February 13, 2015): 737–50. http://dx.doi.org/10.1161/circresaha.116.302521.

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49

Siyu, Gu, Zou Linqing, Kong Linling, Liu Hong, Song Guoqi, and William C. Cho. "Long noncoding RNA identification in lymphoma." Future Oncology 13, no. 27 (November 2017): 2479–87. http://dx.doi.org/10.2217/fon-2017-0230.

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50

Rayner, Katey J., and Peter P. Liu. "Long Noncoding RNAs in the Heart." Circulation: Cardiovascular Genetics 9, no. 2 (April 2016): 101–3. http://dx.doi.org/10.1161/circgenetics.116.001413.

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