Dissertations / Theses on the topic 'Long-term loss of strength'
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the top 50 dissertations / theses for your research on the topic 'Long-term loss of strength.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.
Büttner, Till, Allessandra Keil, Jeanette Orlowsky, and Michael Raupach. "Einsatz von Polymeren in Textilbeton – Entwicklung polymermodifizierter Betone und Einflüsse auf die Dauerhaftigkeit." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2009. http://nbn-resolving.de/urn:nbn:de:bsz:14-ds-1244045457582-60801.
Full textStudzienko, Sharon. "Factors involved in long term maintenance of weight loss." Instructions for remote access. Click here to access this electronic resource. Access available to Kutztown University faculty, staff, and students only, 1991. http://www.kutztown.edu/library/services/remote_access.asp.
Full textHodgson, D. A. "The short and long term electric strength of polyethylene insulation." Thesis, University of Southampton, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.384272.
Full textRoberts, Laura McCoy. "The Long-Term Effects of Bereavement: A Longitudinal Study." Thesis, University of North Texas, 1994. https://digital.library.unt.edu/ark:/67531/metadc278017/.
Full textKim, Seung Dae. "Prediction of long-term prestress loss in concrete box girder bridges." Diss., [La Jolla] : University of California, San Diego, 2009. http://wwwlib.umi.com/cr/ucsd/fullcit?p3355852.
Full textTitle from first page of PDF file (viewed July 2, 2009). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 341-345).
Pascual, Rebecca W. "Diet Quality and Micronutrient Intake in Long-Term Weight Loss Maintainers." DigitalCommons@CalPoly, 2019. https://digitalcommons.calpoly.edu/theses/2058.
Full textLin, Qiaoxing. "Strength degradation and damage micromechanism of granite under long-term loading." Click to view the E-thesis via HKUTO, 2006. http://sunzi.lib.hku.hk/hkuto/record/B37115406.
Full textLin, Qiaoxing, and 林僑興. "Strength degradation and damage micromechanism of granite under long-term loading." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B37115406.
Full textVoght, Angela Marie. "What is the long-term impact of early mother loss on daughters?" Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/MQ64751.pdf.
Full textKidd, Cory David 1977. "Designing for long-term human-robot interaction and application to weight loss." Thesis, Massachusetts Institute of Technology, 2008. http://hdl.handle.net/1721.1/42407.
Full textIncludes bibliographical references (p. 241-251).
Human-robot interaction is now well enough understood to allow us to build useful systems that can function outside of the laboratory. This thesis defines sociable robot system in the context of long-term interaction, proposes guidelines for creating and evaluating such systems, and describes the implementation of a robot that has been designed to help individuals effect behavior change while dieting. The implemented system is a robotic weight loss coach, which is compared to a standalone computer and to a traditional paper log in a controlled study. A current challenge in weight loss is in getting individuals to keep off weight that is lost. The results of our study show that participants track their calorie consumption and exercise for nearly twice as long when using the robot than with the other methods and develop a closer relationship with the robot. Both of these are indicators of longer-term success at weight loss and maintenance.
by Cory David Kidd.
Ph.D.
Lane, April D. "INCREASING LONG TERM WEIGHT LOSS SUCCESS: AN INDIVIDUALIZED, HOLISTIC, SELF-CARE MODEL." CSUSB ScholarWorks, 2014. https://scholarworks.lib.csusb.edu/etd/13.
Full textLanham, Ann Catherine. "Evaluating the psychological predictors of long term weight loss following bariatric surgery." Thesis, University of Leeds, 2015. http://etheses.whiterose.ac.uk/10739/.
Full textGoldberg, Caroline. "And her children shall rise, the long-term effects of early mother loss." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0016/MQ48508.pdf.
Full textGoldberg, Caroline (Caroline Geta) Carleton University Dissertation Social Work. ""And her children shall rise"; the long-term effects of early mother loss." Ottawa, 1999.
Find full textBedard, Marc. "Long-Term Cognitive Impairment Following Mild Traumatic Brain Injury with Loss of Consciousness." Thesis, Université d'Ottawa / University of Ottawa, 2021. http://hdl.handle.net/10393/41923.
Full textAkers, Jeremy Dewayne. "Increased Water Consumption: A Self-Regulatory Strategy for Long-Term Weight Loss Maintenance?" Diss., Virginia Tech, 2010. http://hdl.handle.net/10919/26668.
Full textPh. D.
Zahnert, Thomas, Robert Mlynski, Hubert Löwenheim, Dirk Beutner, Rudolf Hagen, Arneborg Ernst, Thorsten Zehlicke, et al. "Long-Term Outcomes of Vibroplasty Coupler Implantations to Treat Mixed/Conductive Hearing Loss." Karger, 2018. https://tud.qucosa.de/id/qucosa%3A38918.
Full textPerret, Olivier. "Strength and Stability of Cross-Laminated-Timber Walls at Short and Long Term." Thesis, Paris Est, 2017. http://www.theses.fr/2017PESC1246/document.
Full textThis PhD thesis addresses the issue of CLT wall buckling. These wooden panels, made of boards which are glued cross-wise, are more and more used in construction. The current trend of the market is to design high-rise buildings which raises the issue of the compressive strength of such walls. It turns out that wood is a highly anisotropic material. Especially, the shear stiffness and strength perpendicular to the grain (rolling shear) are much weaker than in the direction parallel to the grain. This high contrast requires more elaborate design criteria than classical tools used in timber engineering. This work is organized in two main parts. First, the equivalent rolling-shear behavior of a CLT layer is investigated. Bounds are established for the stiffness of an equivalent layer using a theoretical approach. These bounds are validated by means of a new experimental set-up which allows the measurement of the rolling shear stiffness with less variability than the classical single lap shear test. In the second part, this data is used in the buckling analysis of CLT walls with increasing refinements. First, the linear buckling load of a thick plate without imperfection is established. This load is based on a new higher-order plate theory and reveals that the critical load based on a thin plate theory (Kirchhoff-Love) cannot predict correctly the strength of CLT walls. Then, the influence of imperfections is introduced adapting the classical approach from Ayrton and Perry to the case of a Timoshenko beam. This extension reveals that a new design criterion has to be satisfied under buckling which is specific to CLT. Finally, this analysis is extended to long term loads assuming a simple creep law and leading to a new simple design criterion which may be easily introduced in current design codes
Merrington, Bill. "The loss of a child : the long term impact upon the parent-child bond." Thesis, University of Warwick, 2003. http://wrap.warwick.ac.uk/2499/.
Full textEvans, Jonathan J. "Neuropsychological mechanisms of very long term memory loss : a cognitive neuropsychological case study approach." Thesis, University of Southampton, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.392639.
Full textAslan, Ozlem. "Predicting Long Term Strength Of Roller Compacted Concrete Containing Natural Pozzolan By Steam Curing." Master's thesis, METU, 2006. http://etd.lib.metu.edu.tr/upload/12607727/index.pdf.
Full textKotrappa, Neel. "The Efficacy of Long-Term Kinesio Tape on Grip Strength in a Healthy Population." Scholarship @ Claremont, 2014. http://scholarship.claremont.edu/cmc_theses/976.
Full textDahiya, Ankuj. "Long-Term Monitoring and Evaluation of the Varina-Enon Bridge." Thesis, Virginia Tech, 2021. http://hdl.handle.net/10919/102891.
Full textMaster of Science
In order to apply a precompression force to concrete structures, post-tensioned concrete employs stressed steel strands. To construct lighter, stiffer structures, this popular building technology can be used. The steel strands undergo a reduction in force known as prestress losses over time. To make good decisions about the remaining life of a structure, the precise calculation of the prestress losses is very important. The Varina-Enon Bridge is a post-tensioned concrete box-girder bridge in Richmond Virginia. In July of 2012, observation of flexural cracks in the bridge by the inspectors promoted a study regarding long-term prestress losses in the structure. Two techniques are used to predict long-term prestress losses for this bridge. A computer model of the bridge is used in the first method to calculate losses using the design code. In order to measure prestress losses, the second technique used data from sensors mounted on the bridge. It was found that the estimation of losses closely matched those predicted at the time of the bridge construction and the computer model results. Based on this the final conclusion is made that the prestress loss in the Varina-Enon Bridge is not significantly more than expected.
Herring, Louisa Y. "Physical activity for optimising and sustaining long-term bariatric surgery outcomes." Thesis, Loughborough University, 2016. https://dspace.lboro.ac.uk/2134/20842.
Full textJumbe, S. E. "Life after weight loss surgery : long term accounts of patients and their health care professionals." Thesis, University of the West of England, Bristol, 2017. http://eprints.uwe.ac.uk/29883/.
Full textLayne, Andrew S., W. Guy Hornsby, D. E. Corriher, H. B. Nowell, Margaret E. Stone, Michael W. Ramsey, and Michael H. Stone. "Long Term Athlete Monitoring: Changes in Isometric Strength and Explosiveness in Division I NCAA Athletes." Digital Commons @ East Tennessee State University, 2009. https://dc.etsu.edu/etsu-works/4109.
Full textPentland, Wendy E. "Upper extremity function in long term paraplegia and implications for independence." Curtin University of Technology, School of Physiotherapy, 1992. http://espace.library.curtin.edu.au:80/R/?func=dbin-jump-full&object_id=15684.
Full textWhen age was excluded, it appeared that duration of SCI was more associated with pain during ADL, but this was significant only for pain during self-care tasks. The tasks most reported to cause upper limb pain were work/school, sleep, wheelchair transfers, outdoor wheeling, and driving. These results suggest that preventative and management steps are required to ensure continued independence and quality of life in this group over time. The effect of duration of SCI suggests that limitations in upper limb function may be seen in this population at relatively young ages.
Waldron, Christopher Joseph. "Investigation of Long-Term Prestress Losses in Pretensioned High Performance Concrete Girders." Diss., Virginia Tech, 2004. http://hdl.handle.net/10919/29672.
Full textPh. D.
Qamar, Muhammad Mustafa. "Long-term strength training reverses the effects of aging on skeletal muscle of health elderly men." Thesis, Örebro universitet, Institutionen för hälsovetenskap och medicin, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-27486.
Full textpresentation was made in august 2012 and thesis is approved and got result as well in november 2012
For an enhanced reading experience go to a later version: http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-31017.
This study was a part of a larger research project studying adaptations to strength, endurance and combined training
Turnbull, Frances L. "Childhood bereavement and its long-term sequelae: a phenomenological investigation of adjustment to early parent death." Thesis, Boston University, 1991. https://hdl.handle.net/2144/37172.
Full textPLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.
This phenomenological study has elicited the remembered mourning reactions of twenty-four men and women who were bereaved of one or both parents between the ages of seven and seventeen. Qualitative methods and a retrospective design were used to explore how subjects grieved, avoided the mourning process, and in ways more or less adaptive, endeavored to master their loss. The major objectives have been to identify some of the shared reactions of this group to premature parent death, and to illuminate their experience of being in the world subsequent to this loss. The study has further explored how parent loss was experienced when bereavement occurred at certain developmental stages (latency or adolescence) , or as a result of particular circumstances (suicide, sudden or anticipated death). The loss experience was remembered as a constellation of changes which both preceded and followed from the parent's actual death. In retrospect, the death was described as a nucleus or formative event around which later developments had been organized. The loss had usually been interpreted by subjects, and the meaning that was made emerged as a deeply personal, idiosyncratic formulation. Parent loss resulted for all in some alteration of their sense of self, in a loss of innocence, and an end of childhood. Particular circumstances had seemingly imposed some special strain or trauma; when the parent's death occurred at a younger age, as a result of prolonged illness, sudden accident or suicide, these deaths appeared to have been more difficult for subjects to resolve than those which resulted at a later age, or from natural causes. Gender differences were also noted: father-bereaved subjects (male and female) were more likely to feel overburdened or engulfed by their widowed parent than were their mother-bereaved counterparts. The phenomenon of early parent loss was described as a complex and multi-faceted event, the understanding and treatment of which may be enhanced by using a variety of theoretical perspectives. Treatment objectives should include helping the bereaved to resume and advance their mourning process and to further those developmental tasks which were not accomplished before the parent's death.
2031-01-01
Gervais, Olivier. "Effects of Long-Term Selection for Non-Destructive Deformation in White Leghorns." 京都大学 (Kyoto University), 2016. http://hdl.handle.net/2433/217200.
Full textBiessy, Guillaume. "Semi-Markov modeling of the loss of autonomy among elderly people : application to long-term care insurance." Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLE048/document.
Full textA sizable challenge to modern societies, Long-Term Care (LTC) in elderly people may be defined as a state of incapacity to perform autonomously part of the Activities of Daily Living (ADL). In most cases, long-term care is caused by pathologies linked to aging. To cope with the sizeable costs linked to this state, private insurers have developed products in top of the public aid. To quantify the long-term care risk, multi-state models are used for which transition probabilities betweenstates (autononomy, death and one to several levels of LTC) need to be inferred. Under the Markov assumption, those probabilities only depend on the current state, this assumption being too restrictive in regards of the complexity of the underlying risk. In a semi-Markov framework, those probabilities also depends on the time spent in the current state. In this thesis, we emphasis the need for the semi-Markov modeling. We demonstrate the impact of time spent in LTC on death probabilities. Besides, we exhibit that taking into account the diversity induced by pathologies leads to sizable improvementsin the fit of the model to experience data. Furthermore, we highlight that the peculiar shape taken by death probabilities as a function of time spent in LTC may be explained by the mixture of pathology groups among the disabled population
Martin-Fernandez, Katy W. "Examining the Utility of the MMPI-2-RF in Predicting Long-Term Bariatric Surgery Outcomes." Kent State University / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=kent162557167935742.
Full textLee, Won-Jun. "Relationship between lower body strength and bone mineral density in postmenopausal women with long-term exercise training." Virtual Press, 2000. http://liblink.bsu.edu/uhtbin/catkey/1177979.
Full textSchool of Physical Education
Oldham, R. H. "The influence of water on long-term strength properties of coal measures rocks associated with mining excavations." Thesis, University of Nottingham, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.355420.
Full textDamiani, Thomas Miles. "A model to predict the long-term strength of e-glass fiber composites subjected to environmental exposure." Morgantown, W. Va. : [West Virginia University Libraries], 2000. http://etd.wvu.edu/templates/showETD.cfm?recnum=1517.
Full textTitle from document title page. Document formatted into pages; contains xiii, 86 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references (p. 81-84).
Mitsui, Yuta. "Study on relationships between frictional strength and long-term fault behavior including evolution of pore fluid pressure." 京都大学 (Kyoto University), 2011. http://hdl.handle.net/2433/135410.
Full textPuhke, Raivo. "Adaptive changes of myosin isoforms in response to long-term strength training in skeletal muscle of middle-aged persons /." Online version, 2006. http://dspace.utlib.ee/dspace/bitstream/10062/1129/5/puhkeraivo.pdf.
Full textTolbert, Shannon Marie. "Enhancing weight gain in long-term care residents at risk for weight loss through protein and calorie fortification." [Johnson City, Tenn. : East Tennessee State University], 2004. http://etd-submit.etsu.edu/etd/theses/available/etd-0329104-095404/unrestricted/TolbertS041204f.pdf.
Full textTitle from electronic submission form. ETSU ETD database URN: etd-0329104-095404. Includes bibliographical references. Also available via Internet at the UMI web site.
Van, Cutsem Gilles. "Late mortality, loss to follow-up, and associated factors in adults on long term antiretroviral therapy in Khayelitsha." Master's thesis, University of Cape Town, 2008. http://hdl.handle.net/11427/10999.
Full textIncludes bibliographical references (leaves 69-72).
The objectives of the study is to estimate baseline characteristics, survival, and factors associated with mortality and losses to follow-up in patients on antiretroviral therapy (ART), and compare the periods before (early) and after (late) 3 months on treatment.
Daftary, Ameet Shirish. "Effect of Long Term Steroids on Cough Efficiency and Respiratory Muscle Strength in Patients with Duchenne Muscular Dystrophy." University of Cincinnati / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1170363103.
Full textAlrowili, Mohammed F. H. "Capacity Enhancement Approaches for Long Term Evolution networks: Capacity Enhancement-Inspired Self-Organized Networking to Enhance Capacity and Fairness of Traffic in Long Term Evolution Networks by Utilising Dynamic Mobile Base-Stations." Thesis, University of Bradford, 2018. http://hdl.handle.net/10454/17322.
Full textReilly, Melissa. "The Lived Experience of Grief After the Death of a Long-Term Companion Animal." Antioch University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=antioch1527018092359502.
Full textLi, Y. "Resource allocation for coordinated multipoint joint transmission system and received signal strength based positioning in long term evolution network." Thesis, University of Liverpool, 2017. http://livrepository.liverpool.ac.uk/3009494/.
Full textAltunsoz, Omur Serdal. "Determine The Effects Of Long Term Playing Soccer On The Degeneration Of Lumbar Spine." Master's thesis, METU, 2006. http://etd.lib.metu.edu.tr/upload/12607487/index.pdf.
Full text/sec and 120º
/sec. Plain lateral radiographs were taken. The presence of degenerative changes of each lumbar vertebra was determined by using the Kellgren and Lowrence Score. A modified Schober test was used to measure lumbar flexion. Findings of the study demonstrated that veteran soccer players displayed greater lumbar disc degeneration than other groups. Moreover, v active soccer group had more BMD than other groups, but the veteran group&
#8217
s BMD results were not different while comparing the control participants. Isokinetic test findings of the current study, trunk extension strength at 60/sec was significantly higher in active 1st group players than 2nd group participants, but there were no significant differences between the 1st group and 2nd group in terms of trunk flexion strength and agonist/antagonist ratio at 60/sec. In conclusion, Findings of the study support the main hypothesis that playing soccer at high intensity training at a long period of time may cause lumbar spine degeneration. Degeneration may occur without low back symptoms. Moreover, results supported the idea that Soccer can be accepted an impact loading sport that are to keep or accelerate bone mineral density. At last, having abnormal trunk extension strength while playing actively may cause lumbar disc degeneration on the spine at later years. A similar study should be carried out with a larger number of subjects, and longitudinal studies should be designed to examine the factors that effect the degeneration on the lumbar spine.
Kavanaugh, Ashley A. "Longitudinal Changes in Strength and Explosive Performance Characteristics in NCAA Division I Women’s Volleyball Athletes." Digital Commons @ East Tennessee State University, 2014. https://dc.etsu.edu/etd/2315.
Full textEsposito, Alessandro. "Creep deflection of low-strength reinforced concrete flexural members strengthened with carbon fiber composite sheets." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amslaurea.unibo.it/10340/.
Full textBrodsky, Rachel Amanda. "Effective Prestress Evaluation of the Varina-Enon Bridge Using a Long-Term Monitoring System and Finite Element Model." Thesis, Virginia Tech, 2020. http://hdl.handle.net/10919/99398.
Full textMaster of Science
Post-tensioned concrete uses stressed steel strands to apply a precompression force to concrete structures. This popular building technology can be used to create lighter, stiffer structures. Over time, the steel strands experience a reduction in force known as prestress losses. Accurately quantifying prestress losses is critical for understanding and maintaining a structure during its remaining service life. The Varina-Enon Bridge is a cable-stayed, prestressed box girder bridge located in Richmond, Virginia. Inspectors noticed cracking in July of 2012 that prompted concerns regarding long-term prestress losses in the structure. Prestress losses were estimated using two methods. The first method utilized a computer model of the full bridge. The second method used data from sensors installed on the bridge to back calculate prestress losses. It was found that the prestress losses estimated from field data were slightly greater than, but closely aligned with, the computer model results. Therefore, it was concluded that the Varina-Enon Bridge has not experienced significantly more prestress losses than expected.
Stenton, Janice, and n/a. "The Long Term Effects of the Fluctuating, Conductive Hearing Loss Caused by Otitis Media with Effusion on Learning and Behaviour for Adolescent Students." Griffith University. School of Cognition, Language and Special Education, 2004. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20040319.142844.
Full textButler, Tiffiny A. "THE EFFECTS OF POST PUBERTAL FOOD RESTRICTION ON BONE ARCHITECTURE, STRENGTH, AND MEDULLARY ADIPOSE COMPOSITION." Diss., Temple University Libraries, 2013. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/244901.
Full textPh.D.
The purpose of this investigation was to determine the effects of post pubertal caloric restriction on bone architecture, strength, and medullary adipose quantity. A randomized control comparison design was utilized and the study was conducted in a laboratory setting. All procedures were approved by the Institutional Animal Care and Use Committee (IACUC) at Temple University (protocol number 3396). Female Sprague Dawley rats (23days-of-age, n=120) were randomly assigned into seven groups, baseline (BL) (n=18), control (C) (n=17), caloric restriction (FR) (n=17), control recovery (RC) (n=17), caloric restriction recovery (RFR) (n=17), control ovariectomy (COVX) (n=17) and food restricted ovariectomy (FROVX) (n=17). On day 65, a 6 week 30% caloric restriction protocol was administered. Following food restriction, a subset of the control and food restricted groups were sacrificed (n=34) and the remaining animals (n=68) control recovery (RC) and food restricted recovery (RFR) groups had a 10 week recovery with ad lib food. Recovery groups, RC and RFR: were sacrificed after the 10 week recovery period at 183 days of age (n=34). The remaining animals were ovariectomized (OVX) and grouped into control ovariectomy (COVX) and food restricted ovariectomy (FROVX). Six weeks post OVX the animals were sacrificed at 270 days of age. After sacrifice blood was taken by cardiac puncture, bones were harvested, cleaned of soft tissue, fixed and prepared for analysis. Anthropometric measurements were taken including retroperitineal and gonadal fat pad weights as well as adrenal glands, ovaries, uteri, and tricep surae muscle group weights. Main Outcome Measures: The outcome variables for this study were bone mechanical competence, trabecular and cortical bone mass and architecture, marrow adipocyte number as well as serum markers of bone formation and resorption. Insulin - like growth factor - 1 (IGF-1) and C- terminal telopeptide (CTX) was measured to determine bone formation and resorption. Statistical Analysis: One-way Analysis of Variance (ANOVA) was performed to determine differences between all groups. Tukey's honestly significant difference (HSD) post hoc analysis was conducted to determine differences between groups. Student's t - tests were used to detect differences between age groups (acute, recovery, post-OVX) A p value was set at less than or equal to 0.05 for all statistical tests. All statistical analysis was performed using (GraphPad Prism version 5.00 for Windows, GraphPad Software, San Diego California USA). Variables were normalized with a linear regression-based correction using body weight. All variables with an R2 level greater than 0 were normalized to avoid choosing an arbitrary R2 value as a cut-off for normalization. Results: Body weight was 18% lower than control animals following caloric restriction. Weight loss was due to fat mass predominately; muscle mass was maintained relative to body weight. Bone length and growth rates were diminished however no differences were found following refeeding. No differences were found in bone strength at any time point. However relative to body weight peak moment and stiffness were significantly higher following caloric restriction. Cortical bones mass and cross sectional moment of inertia were enhanced in the femoral diaphysis with bone mass greater post OVX in the calorically restricted group (FR-OVX). No significant differences were found in ash percent in the femur was found between any groups at any time point however vertebral bone mineral density in acute FR and post OVX time points in FROVX was significantly greater indicating an enhanced bone quality in the restricted. No change in trabecular quantity or quality were observed in the distal femur between groups however vertebral trabecular architecture was enhanced in number and thickness in acute FR and post OVX time points in FROVX. No significant difference in number of marrow adipocytes were found at any time point. Serum CTX decreased significantly in acute in FR and increased at recovery in RFR and post OVX in FROVX. Serum IGF - 1 decreased in the acute FR with IGF - 1 significantly greater after recovery in RFR. Conclusions: Evidence was found to suggest that moderate caloric restriction (nutrient replete) post puberty was positive for bone. Bone quantity was increased with relative cortical area and bone area relative to body weight increased in the FR group. Significant increases in FROVX bone quantity post OVX suggests that bone mass gains during caloric restriction attenuated cortical bone loss at maturity post OVX. Bone quality increases in cross sectional moment of inertia relative to body weight may have accounted for the transient increase in FR bone strength in the femur. Decreases in acute CTX and IGF- 1 levels indicates that bone formation and resorption were decreased during development that may have been the mechanism for bone loss attenuated post OVX in calorically restricted. Growth rate slowing during caloric restriction may have decreased the rate of formation and resorption during a crucial time of peak bone mass accrual and bone modeling. This decrease in one modeling may have been mechanism that preserved bone quantity during acute caloric restriction. Increases in femur quality in polar moment of inertia coupled with a decrease in bone length changed the shape of the bone making it more robust. A shorter bone with a thicker cortex with no change in mineral content may have been the mechanism in the transient increase in bone strength in the femur. Quality changes in mineral density in vertebrae acting as a mineral storage back up as a last resort if quantity and quality changes were not sufficient in maintain bone strength. Moderate caloric restriction transiently increased strength, by increasing bone mass relative to body, altering bone geometry and increased vertebral mineral density.
Temple University--Theses