Relevant bibliographies by topics / LOQ- Limit of quantification

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters
  4. Conference papers

Academic literature on the topic 'LOQ- Limit of quantification'

Author: Grafiati
Published: 4 June 2021
Last updated: 9 February 2022

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Journal articles on the topic "LOQ- Limit of quantification"

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Ershadi, Saba, and Ali Shayanfar. "Are LOD and LOQ Reliable Parameters for Sensitivity Evaluation of Spectroscopic Methods?" Journal of AOAC INTERNATIONAL 101, no. 4 (2018): 1212–13. http://dx.doi.org/10.5740/jaoacint.17-0363.

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Abstract The limit of detection (LOD) and the limit of quantification (LOQ) are common parameters to assess the sensitivity of analytical methods. In this study, the LOD and LOQ of previously reported terbium sensitized analysis methods were calculated by different methods, and the results were compared with sensitivity parameters [lower limit of quantification (LLOQ)] of U.S. Food and Drug Administration guidelines. The details of the calibration curve and standard deviation of blank samples of three different terbium-sensitized luminescence methods for the quantification of mycophenolic acid
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Syahrir, Muhammad, Nurul Hidayat Aprilita, and Nuryono Nuryono. "VALIDASI METODE ANALISIS POLISIKLIK AROMATIK HIDROKARBON (PAH) DALAM SEDIMEN DI SEKITAR PANTAI MAKASSAR." Jurnal Kimia Terapan Indonesia 17, no. 1 (2015): 9–14. http://dx.doi.org/10.14203/jkti.v17i1.18.

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Validation of analysis method of PAH have been done in marine sediment of Macassar Coast by Gas Chromatography (GC-FID). Validation of method include: limit of detection (LoD), limit of quantification (LoQ) and linearity range. The results of validation method of 7 types PAHs (Naphtalene, Acenaphtene, Penanthrene, Fluoranthene, Pyrene, Benzo (a) Anthracene and perylene) give a linearity range between 0.5 to 20 ppm with an average linearity approaches a value of 1. LoD for Naphtalene; Acenaphthene; Penanthrene; Fluoranthene; Pyrene; Benzo (a) Anthracene; and Perylene are 3.541; 0.208; 1,736; 1.
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Le Thi, Lien, Anh Bach Thuy, Khanh Cao Cong, Ha Tran Nguyen, and Hong Hao Le Thi. "Determination of crinamidine in dietary supplements by GC-MS/MS." Heavy metals and arsenic concentrations in water, agricultural soil, and rice in Ngan Son district, Bac Kan province, Vietnam 1, no. 1 (2018): 3–7. http://dx.doi.org/10.47866/2615-9252/vjfc.48.

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The determination of crinamidine in dietary supplements content by mass spectrometry (GC-MS/MS) was developed and validated. The method was performed on the DB5MS column (30m x 0,25mm; 0,25 μm), in combination with the tandem mass spectrometry. The parameters of the method were evaluated for selectivity, calibration curve, accuracy, precision, limit of detection (LOD) and limit of quantification (LOQ). The calibration curve was highly linear (the coefficient of determination 0.9970) within the concentration range of 5ppm-50ppm. The recovery at three concentrat
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Parachalil, Drishya Rajan, Deirdre Commerford, Franck Bonnier, Igor Chourpa, Jennifer McIntyre, and Hugh J. Byrne. "Raman spectroscopy as a potential tool for label free therapeutic drug monitoring in human serum: the case of busulfan and methotrexate." Analyst 144, no. 17 (2019): 5207–14. http://dx.doi.org/10.1039/c9an00801b.

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A methodology is proposed, based on Raman spectroscopy coupled with multivariate analysis, to determine the Limit of Detection (LOD) and Limit of Quantification (LOQ) for therapeutic drug monitoring in human serum, using the examples of Busulfan and Methotrexate.
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Gowtham Reddy Cheruku, Sai Laasya Mithinti, and Purushotham Saidu. "UV Spectrophotometric Method Development and Validation of Esomeprazole in Bulk and Pharmaceutical Dosage Forms." International Journal of Research in Pharmaceutical Sciences 12, no. 3 (2021): 2286–90. http://dx.doi.org/10.26452/ijrps.v12i3.4855.

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The work discusses method development and validation. An uncomplicated, accurate, and straightforward method was developed for the drug Esomeprazole in bulk as well as Pharmaceutical dosage form. NaOH was used as the solvent. The maximum wavelength (ʎ max) for Esomeprazole was found to be 305nm. The validation was performed as per International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use (ICH) guidelines for Accuracy linearity, precision, Limit of Detection (LOD) and Limit of Quantification (LOQ). Esomeprazole's recovery percentage (%) was 100.20%, res
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Kumar, Anil, Dilip Agarwal, and Mukesh Bansal. "Method Development and Validation of A Novel Anti-Depressant Bupropion by RP-HPLC." Asian Journal of Pharmaceutical Research and Development 8, no. 3 (2020): 211–24. http://dx.doi.org/10.22270/ajprd.v8i3.720.

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A speedy, simple and precise RP-HPLC process was developed for the estimation of novel antidepressant drug bupropion with Waters X – Bridge C-18 5µm, 4.6 X 150 mm columnusing mobile phase Acetonitrile: Ammonium bicarbonate (5mM) pH-9 adjusted with 1% Ammonium hydroxide (50:50, %v/v).The flow rate was 1 ml/min and quantification was done by PDA detector at wavelength254nm.The Bupropion eluted from the column in 5.194 min. The validation was carried out in the light of ICH guidelines with respect to parameters linearity, specificity, accuracy, limit of detection (LOD) and limit of quantification
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Jovanovic, Slobodan V., Thomas Zakharov, Hemendra Mulye, Duck Kim, and Kelly-Anne Fagan. "Determination of hydrazine at Ontario nuclear power plants." Analytical Methods 7, no. 23 (2015): 9825–34. http://dx.doi.org/10.1039/c5ay02178b.

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In this study, we developed and validated a sensitive method for the determination of hydrazine in water samples using ion chromatography coupled with an amperometric detector (limit of detection (LOD) = 0.02 μg L<sup>−1</sup> and limit of quantification (LOQ) = 0.1 μg L<sup>−1</sup>).
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Doctor, Jwal, Palak Thakkar, Mitul Prajapati, Nrupresh Patel, and Priti J. Mehta. "NON-DESTRUCTIVE RAMAN SPECTROSCOPIC METHOD FOR ESTIMATION OF MONTELUKAST FROM TABLET DOSAGES FORM." International Journal of Pharmacy and Pharmaceutical Sciences 9, no. 6 (2017): 161. http://dx.doi.org/10.22159/ijpps.2017v9i6.14043.

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Objective: A rapid, non-destructive and non-solvent raman spectroscopic method for estimation of Montelukast from tablet dosages form Methods: Quantification was carried out by measuring the intensity of analyte peak at 1440 cm-1. Each Raman spectrum corresponded to an accumulation of 4 scans with an exposure time of 5 sec for each scan with a total integration time of 20 sec.Results: The method exhibited linearity between 2 mg-24 mg show well resolve quantification From MON. The linearity equation was calculated as y = 13.036x+70.819 and the correlation coefficient was found to be 0.997 for M
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Barros, G., D. García, S. Oviedo, M. Ramirez, A. Torres, and S. Chulze. "Deoxynivalenol and nivalenol analysis in soybean and soy flour." World Mycotoxin Journal 1, no. 3 (2008): 263–66. http://dx.doi.org/10.3920/wmj2008.1052.

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A rapid and accurate method of quantifying deoxynivalenol (DON) and nivalenol (NIV) in soybean and soy flour is described. The samples were extracted with acetonitrile:water (84:16, v/v) and cleaned through a solidphase extraction (SPE) column. The mycotoxins were separated, detected and quantified by reversed-phase high performance liquid chromatography (HPLC) with UV detection (220 nm) using water:methanol (88:12, v/v) as mobile phase. Characteristics of this in-house method such as accuracy, precision and detection and quantification limits were defined by means of a recovery test with spik
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Bhavani N. L. D., Gowtham Reddy Cheruku, Bhargava Sri Harsha Polina, Dheeraj Kotagiri, and Jnanendra Kumar Korukollu. "Development and Validation of UV Spectrophotometric Method of Mesalamine Using Hydrotropic Solubilizing Agents." International Journal of Research in Pharmaceutical Sciences 12, no. 3 (2021): 2291–96. http://dx.doi.org/10.26452/ijrps.v12i3.4856.

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The work was proposed to discuss method development and validation of the drug Mesalamine by using hydrotropic solubilizing agents. An uncomplicated, accurate, and precise method was developed for the drug Mesalamine in bulk as well as Pharmaceutical dosage form. 5M Urea was used as the hydrotropic solubilizing agent to enhance the solubility of the drug. The maximum wavelength (ʎ max) for Mesalamine was found to be 241nm. The validation was performed as per International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use (ICH) guidelines for Accuracy, linear
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Dissertations / Theses on the topic "LOQ- Limit of quantification"

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Oranzie, Marlon. "Electrochemical Aptasensing of B-Type Natriuretic Peptide-A Biomarker for Myocardial Infarction." University of the Western Cape, 2019. http://hdl.handle.net/11394/7707.

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>Magister Scientiae - MSc<br>infarction (MI) affects many parts of the western world and in South Africa alone it is estimated that MI is responsible for 1 in 6 deaths (17.3%). Traditional diagnostic methods for MI include an electrocardiograms and blood tests. The problem with these diagnostic methods are that they are time consuming, require large sample volumes, expensive equipment and complicated machinery. To achieve early detection of MI the discovery of specific, sensitive and reliable biomarkers are required. Brain natriuretic peptide (BNP) has been identified as a reliable biomarker f
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Ngwanya, Olwethu. "Molecularly imprinted polymers for detection of volatile organics associated with fuel combustion." University of the Western Cape, 2018. http://hdl.handle.net/11394/6363.

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Magister Scientiae - MSc (Chemistry)<br>Pollutants such as polycyclic aromatic hydrocarbons (PAHs) are known for their toxic effects which may lead to the cause of degenerative diseases in both humans and animals. PAHs are widespread in the environment, and may be found in water, food, automotive industry and petrochemical industries to name but a few sources. Literature reports have highlighted industrial workplace exposure to PAHs as a leading cause for development of cancer in workers. Particularly, workers in the petrochemical industry are adversely affected and the incidence of skin and l
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Nguyen, Thi Huyen Tram. "Handling data below the quantification limit in viral kinetic modeling for model evaluation and prediction of treatment outcome." Paris 7, 2014. http://www.theses.fr/2014PA077224.

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Les modèles de cinétique virale (VK) aident à comprendre le cycle de vie du virus de l'hépatite C et les mécanismes d'action des antiviraux. Inclure des informations pharmacocinétiques (PK) dans ces modèles permet de mieux comprendre la réponse virologique. Ces modèles pourraient aider à prédire l'issue du traitement pour chaque patient et personnaliser le traitement. Les données sous la limite de quantification (LOQ) sont très fréquentes dans la modélisation VK. L'impact de ces données et la méthode pour en tenir compte dans l'évaluation de modèle et la prédiction de la réponse thérapeutique
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Martin-Rémy, Aurélie. "Analyse de données de biométrologie : aspects méthodologiques et applications." Thesis, Université de Lorraine, 2018. http://www.theses.fr/2018LORR0223/document.

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De nombreuses études de biométrologie sont menées à l’INRS, pour évaluer l’exposition professionnelle à des substances chimiques, en France, et pour compléter les connaissances en proposant des valeurs de références destinées à protéger des salariés exposés à ces substances. Ces études consistent à mesurer simultanément l’imprégnation biologique et l’exposition atmosphérique à une substance, chez des salariés exposés à celle-ci. La relation entre ces mesures biologiques et atmosphériques est ensuite estimée à travers un modèle de régression linéaire. Lorsque que cette relation existe et que la
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Liu, Yating. "Optimal Quantization : Limit Theorem, Clustering and Simulation of the McKean-Vlasov Equation." Thesis, Sorbonne université, 2019. http://www.theses.fr/2019SORUS215.

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Cette thèse contient deux parties. Dans la première partie, on démontre deux théorèmes limites de la quantification optimale. Le premier théorème limite est la caractérisation de la convergence sous la distance de Wasserstein d’une suite de mesures de probabilité par la convergence simple des fonctions d’erreur de la quantification. Ces résultats sont établis en Rd et également dans un espace de Hilbert séparable. Le second théorème limite montre la vitesse de convergence des grilles optimales et la performance de quantification pour une suite de mesures de probabilité qui conv
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Soret, Perrine. "Régression pénalisée de type Lasso pour l’analyse de données biologiques de grande dimension : application à la charge virale du VIH censurée par une limite de quantification et aux données compositionnelles du microbiote." Thesis, Bordeaux, 2019. http://www.theses.fr/2019BORD0254.

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Dans les études cliniques et grâce aux progrès technologiques, la quantité d’informations recueillies chez un même patient ne cesse de croître conduisant à des situations où le nombre de variables explicatives est plus important que le nombre d’individus. La méthode Lasso s'est montrée appropriée face aux problèmes de sur-ajustement rencontrés en grande dimension.Cette thèse est consacrée à l'application et au développement des régressions pénalisées de type Lasso pour des données cliniques présentant des structures particulières.Premièrement, chez des patients atteints du virus de l'immunodéf
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Moro, Marcos Vinicius. "Estudos de técnicas de feixes iônicos para a quantificação do elemento químico boro." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/43/43134/tde-24092014-133916/.

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Neste trabalho, estudamos e aplicamos técnicas analíticas com feixes iônicos para a identificação e quantificação do elemento químico Boro em amostras de Boro depositado sobre Níquel 11B/Ni, sobre Silício B/Si e em amostras de Silício Grau Metalúrgico - SiGM. Estas últimas foram fornecidas pelo grupo de metalurgia do Instituto de Pesquisas Tecnológicas (IPT). Especificamente, as seguintes técnicas analíticas foram utilizadas: Nuclear Reaction Analysis - NRA, Elastic Recoil Detection Analysis - ERDA e Secondary Ion Mass Spectrometry - SIMS. Nas amostras de B/Ni e B/Si, as concentrações foram ob
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Boudjellal, Abdelouahab. "Contributions à la localisation et à la séparation de sources." Thesis, Orléans, 2015. http://www.theses.fr/2015ORLE2063.

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Les premières recherches en détection, localisation et séparation de signaux remontent au début du 20ème siècle. Ces recherches sont d’actualité encore aujourd’hui, notamment du fait de la croissance rapide des systèmes de communications constatée ces deux dernières décennies. Par ailleurs, la littérature du domaine consacre très peu d’études relatives à certains contextes jugés difficiles dont certains sont traités dans cette thèse. Ce travail porte sur la localisation de signaux par détection des temps d’arrivée ou estimation des directions d’arrivée et sur la séparation de sources dépendant
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McGowan, Yan. "Predicting drug residue depletion to establish a withdrawal period with data below the limit of quantitation (LOQ)." Diss., 2018. http://hdl.handle.net/2097/39376.

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Doctor of Philosophy<br>Department of Statistics<br>Christopher Vahl<br>Veterinary drugs are used extensively for disease prevention and treatment in food producing animals. The residues of these drugs and their metabolites can pose risks for human health. Therefore, a withdrawal time is established to ensure consumer safety so that tissue, milk or eggs from treated animals cannot be harvested for human consumption until enough time has elapsed for the residue levels to decrease to safe concentrations. Part of the process to establish a withdrawal time involves a linear regression to model dr
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Suryawanshi, Anup Arvind. "Uncertainty Quantification in Flow and Flow Induced Structural Response." Thesis, 2015. http://etd.iisc.ernet.in/2005/3875.

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Response of flexible structures — such as cable-supported bridges and aircraft wings — is associated with a number of uncertainties in structural and flow parameters. This thesis is aimed at efficient uncertainty quantification in a few such flow and flow-induced structural response problems. First, the uncertainty quantification in the lift force exerted on a submerged body in a potential flow is considered. To this end, a new method — termed here as semi-intrusive stochastic perturbation (SISP) — is proposed. A sensitivity analysis is also performed, where for the global sensitivity analysi
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Book chapters on the topic "LOQ- Limit of quantification"

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Eremenko, Arkadiy, Il'ya Kurochkin, and Nataliya Nechaeva. "Bioanalytical systems based on cholinesterases for detection of organophosphates." In ORGANOPHOSPHORUS NEUROTOXINS. Publishing Center RIOR, 2020. http://dx.doi.org/10.29039/32_205-218.

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Various types of electrochemical sensors based on the inhibition of butyrylcholinesterase (BChE) have been presented for the analysis of organophosphates (OPC). A special design of thick film sensors and electrochemical detector for cholinesterases assay and their inhibitors in aqueous samples has been developed. For this assay, thiol sensitive sensors based on screen printed graphite electrode modified with nanoparticles of manganese dioxide were used. High sensitivity of manganese dioxide modified thick film sensors towards thiocholine and therefore low detection limit of BChE (1 pM) enabled their use for subnanomolar detection of an organophosphate pesticide diazinon, and other irreversible inhibitors of BChE. This work also presents modern innovative approach for the analysis of BChE by Raman spectroscopy. New SERS-substrates based on silver paste for sensitive quantification of BChE activity were obtained, characterized and applied to thiocholine detection, with LOD (TCh) being 260 nM. Real samples of human plasma were analyzed; a good correlation between spectrophotometric detection and Raman detection was shown. The developed technique is inexpensive and easy-to-use and has promising potential for analysis of OPC.
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Eremenko, Arkadiy, Il'ya Kurochkin, and Nataliya Nechaeva. "Bioanalytical systems based on cholinesterases for detection of organophosphates." In Organophosphorous Neurotoxins. Publishing Center RIOR, 2020. http://dx.doi.org/10.29039/chapter_5e4132b6096d14.18045940.

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Various types of electrochemical sensors based on the inhibition of butyrylcholinesterase (BChE) have been presented for the analysis of organophosphates (OPC). A special design of thick film sensors and electrochemical detector for cholinesterases assay and their inhibitors in aqueous samples has been developed. For this assay, thiol sensitive sensors based on screen printed graphite electrode modified with nanoparticles of manganese dioxide were used. High sensitivity of manganese dioxide modified thick film sensors towards thiocholine and therefore low detection limit of BChE (1 pM) enabled their use for subnanomolar detection of an organophosphate pesticide diazinon, and other irreversible inhibitors of BChE. This work also presents modern innovative approach for the analysis of BChE by Raman spectroscopy. New SERS-substrates based on silver paste for sensitive quantification of BChE activity were obtained, characterized and applied to thiocholine detection, with LOD (TCh) being 260 nM. Real samples of human plasma were analyzed; a good correlation between spectrophotometric detection and Raman detection was shown. The developed technique is inexpensive and easy-to-use and has promising potential for analysis of OPC.
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Poetschke, Julian, and Gerd G. Gauglitz. "Objective Assessment Technologies: General Guidelines for Scar Assessment." In Textbook on Scar Management. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-44766-3_16.

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AbstractScar assessment has long relied on a variety of instruments, most of them questionnaires or scales that are susceptible to bias and limit the level of evidence in research. Throughout recent years, a variety of objective assessment tools have been developed. They allow for the exact quantification of different scar parameters such as texture, pliability, color, and size, thus facilitating detailed progress analysis throughout treatment.The advent of new technology, however, has its pitfalls, too. The number of different technologies available is hard to review, and oftentimes, clinical validation is lacking, making it hard for researchers to gauge whether a certain instrument is adequate for their individual projects.The use of each individual instruments has different requirements regarding patient preparation and calibration, and the measurements themselves can often be adjusted through a variety of parameters. This requires intensive familiarization with the respective instruments. Additionally, interpretation of the data can be complicated, and distinguishing statistically significant differences from clinically important differences remains difficult.Modern technology, however, allows researchers to measure treatment effects that otherwise would have eluded them through the use of subjective evaluation only.Through objective scar assessment technology and its detailed abilities to document changes throughout treatment, the evidence in scar-related research can be greatly improved, and current as well as new treatment options can finally be adequately gauged for their efficacy.
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Demir, Ersin, Hülya Silah, and Nida Aydogdu. "Electrochemical Applications for the Antioxidant Sensing in Food Samples Such as Citrus and Its Derivatives, Soft Drinks, Supplementary Food and Nutrients." In Citrus [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.96873.

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Although there are many definitions of antioxidants, the most general description; antioxidants are carried a phenolic function in their structure and prevent the formation of free radicals or intercept from damage to the cell by scavenging existing radicals. Moreover, they are one of the most effective substances that contain essential nutrients for healthy individuals. The importance of these antioxidants, which have an incredible effect on the body and increase the body’s resistance, is increasing day by day for healthy individuals. Numerous studies have been carried out for antioxidants with excellent properties and however new, reliable, selective, sensitive and green analytical methods are sought for their determination at trace levels in food samples. Along with the latest developments, electrochemical methods are of great interest in the world of science because they are fast, reliable, sensitive and environmentally friendly. Electrochemical methods have been frequently applied to analyze antioxidant capacity in many nutrients samples found in different forms such as solid, liquid without any pretreatment applications in the last decade. Furthermore, these methods are preferred because of the short analysis time, the ability to lower detection limits, reduction in a solvent, high sensitivity, portability, low sample consumption, wide working range, and more economical than existing other traditional analytical methods. The antioxidant sensing applications by modern electrochemical methods such as cyclic, square wave, differential pulse, and combined with stripping voltammetric techniques were used to deduce antioxidant capacity (AC) in critical nutrients. Moreover, this chapter includes a description of the classification of electrochemical methods according to the working electrode type, dynamic working range, limit of determination (LOD), limit of quantification (LOQ), sample type, and using standard analyte and so forth for each voltammetric methods. While many articles applied for the determination of antioxidant sensing by electrochemistry have gained momentum in the last two decades, we focused on the studies conducted over the last 4 years in this chapter.
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Bernal, Ernesto. "Limit of Detection and Limit of Quantification Determination in Gas Chromatography." In Advances in Gas Chromatography. InTech, 2014. http://dx.doi.org/10.5772/57341.

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Bolse, Nico, Anne Habermehl, Carsten Eschenbaum, and Uli Lemmer. "Fluorescence Quenching Sensor Arrays for the Discrimination of Nitroaromatic Vapors." In Electronic Nose Technologies and Advances in Machine Olfaction. IGI Global, 2018. http://dx.doi.org/10.4018/978-1-5225-3862-2.ch004.

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Fluorescence quenching is a promising technique for chemical sensing applications such as the detection of explosive trace vapors. Nitroaromatic explosives are one of the primary targets for this approach enabling ultra-low detection limits down to sub parts-per-billion in air. Many studies, however, focus on enhanced sensor sensitivity, whereas practical applications often require the identification and quantification of detected species. Electronic noses and efficient sensor systems are a promising solution to address this challenge. The authors review recent approaches and trends for explosive trace vapor detection and discuss theoretical concepts for fluorescence quenching as well as target analytes, sensor materials, and fabrication techniques. Statistical learning techniques such as principal component analysis and linear discriminant analysis, sensor systems, and camera-based read-out strategies are in the focus of the chapter. The authors conclude with recommendations and solutions for the elaborated challenges and with visions on future research directions.
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Zia Uddin Kamal, Mohammed, and Md Yunus Miah. "Arsenic Speciation Techniques in Soil Water and Plant: An Overview." In Arsenic [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.99273.

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There are more than 100 different arsenic with different characteristics in the soil-water-plant ecosystem. The identification and quantification of individual arsenic species is essential for understanding the distribution, environmental fate and behavior, metabolism and toxicity of arsenic. Due to the hazardous nature of arsenic, people have a high interest in the measurement of arsenic species. The reaction of the formation of arsenic speciation in the soil-water-plant environment is briefly studied. There is little information on methods used to quantify arsenic forms and species in contaminated soil, water and plant. The purpose of this article is to understand the available sample pretreatment, extraction, separation, detection and method validation techniques for arsenic speciation analysis of arsenic species in soil, water and plant. The performances of various sample preparation and extraction processes, as well as effective separation techniques, that contribute greatly to excellent sensitivity and selectivity in arsenic speciation when coupling with suitable detection mode, and method validity are discussed. The outlines of arsenic speciation techniques are discussed in view of the importance to the completeness and accuracy of analytical data in the soil-water-plant samples. To develop cheap, fast, sensitive, and reproducible techniques with low detection limits, still needed to confine research on arsenic speciation present in environmental matrices.
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Osterlind, Steven J. "The Patterns of Large Numbers." In The Error of Truth. Oxford University Press, 2019. http://dx.doi.org/10.1093/oso/9780198831600.003.0004.

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This chapter advances the historical context for quantification by describing the climate of the day—social, cultural, political, and intellectual—as fraught with disquieting influences. Forces leading to the French Revolution were building, and the colonists in America were fighting for secession from England. During this time, three important number theorems came into existence: the binomial theorem, the law of large numbers, and the central limit theorem. Each is described in easy-to-understand language. These are fundamental to how numbers operate in a probability circumstance. Pascal’s triangle is explained as a shortcut solving some binomial expansions, and Jacob Bernoulli’s Ars Conjectandi, which presents the study of measurement “error” for the first time, is discussed. In addition, the central limit theorem is explained in terms of its relevance to probability theory, and its utility today.
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Marwick, Thomas H. "Coronary heart disease." In ESC CardioMed, edited by Frank Flachskampf. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198784906.003.0089.

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Echocardiography is a vital part of the assessment of patients with known or suspected coronary artery disease. In the acute setting, the absence of wall motion abnormalities in a patient with ongoing chest pain is reassuring, and echocardiography provides a means of excluding alternative diagnoses. In patients with a complicated course, the technique provides the ability to evaluate left ventricular ejection fraction and haemodynamics in heart failure, the pericardium, evidence of disturbances of myocardial or valvular structure, and function (relevant to the mechanical complications of infarction). Cardiac imaging is indispensable in the management of heart failure, and echocardiography is the most widely used test for this purpose. However, no single test satisfies all imaging requirements in heart failure. In the non-acute setting, stress echocardiography is helpful for the recognition and prognostic evaluation of coronary artery disease, and in stable chronic disease, dobutamine stress echocardiography can be used to recognize myocardial viability. The challenges to echocardiography in all of these settings pertain to adequate training, the need for quantification of regional function, and the need to limit the use of this test to situations where it will influence management.
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Carpignano, Andrea, Daniele Grosso, Raffaella Gerboni, and Andrea Bologna. "Resilience of Critical Infrastructures: A Risk Assessment Methodology for Energy Corridors." In Issues on Risk Analysis for Critical Infrastructure Protection [Working Title]. IntechOpen, 2020. http://dx.doi.org/10.5772/intechopen.94755.

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The need for scientific methodologies to assess quantitatively the resilience of critical infrastructures against natural hazards (like earthquakes, floods, storms, landslides and wildfires) during the last decade has become a relevant aspect for several countries and for the European Union. In fact, this quantification could allow setting and implementing effective measures to prevent or mitigate the negative socio-economic effects that a possible disruption of these infrastructures, caused by extreme natural events, could cause. This paper focuses, in particular, on energy corridors and proposes a new approach for evaluating their resilience, based on the definition of a criticality index able to estimate the economic damage associated to all the hazards by taking into account the spatial dimension of the infrastructure and by combining different interdependent parameters that could affect the criticality level. The procedure was tested by means of an application to a simplified case study. The obtained results highlighted the main advantages of the defined method, especially in ranking the critical sections of the infrastructure and prioritising the investments for reinforcing and protecting it or in identifying the further tests to be performed, especially in the case of a reassessment of the acceptable risk limit.
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Conference papers on the topic "LOQ- Limit of quantification"

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Garcia-Cardona, Cristina, Yen Ting Lin, and Tanmoy Bhattacharya. "UNCERTAINTY QUANTIFICATION FOR DEEP LEARNING REGRESSION MODELS IN THE LOW DATA LIMIT." In 4th International Conference on Uncertainty Quantification in Computational Sciences and Engineering. Institute of Research and Development for Computational Methods in Engineering Sciences (ICMES), 2021. http://dx.doi.org/10.7712/120221.8045.19145.

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Corral, Roque, and Almudena Vega. "The Low Reduced Frequency Limit of Vibrating Airfoils: Part IIIA — Theoretical Quantification and Influence of Unsteady Loading." In ASME Turbo Expo 2016: Turbomachinery Technical Conference and Exposition. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/gt2016-57213.

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This paper studies the unsteady aerodynamics of vibrating airfoils in the low reduced frequency regime with special emphasis on its impact on the work per cycle curves. In Part I of the corresponding paper, a perturbation analysis of the linearized Navier-Stokes equations for real modes at low reduced frequency was presented and some conclusions were drawn. It was discovered that a new parameter, the unsteady loading, plays an essential role in the trends of the phase and modulus of the unsteady pressure caused by the oscillation of the airfoil. In this third (a) part, the theory is extended i
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Vega, Almudena, and Roque Corral. "The Low Reduced Frequency Limit of Vibrating Airfoils: Part IIIB — Numerical Quantification and Influence of Unsteady Loading." In ASME Turbo Expo 2016: Turbomachinery Technical Conference and Exposition. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/gt2016-57288.

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This paper studies the unsteady aerodynamics of vibrating airfoils in the low reduced frequency regime with special emphasis on its impact on the work per cycle curves. Simulations using a frequency domain linearized Navier-Stokes solver have been carried out on rows of a low-pressure turbine airfoil section, the NACA65 section and a flat plate, to show the correlation between the actual value of the unsteady loading parameter (ULP), theoretically derived in Part IIIa, and the flutter characteristics, for different airfoils, operating conditions and mode-shapes. Both, the traveling-wave and in
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Jofre, M., J. M. Perez, P. Martinez, et al. "CMOS-based Image Cytometry for Detection of Phytoplankton in Ballast Water." In IMarEST Ballast Water Technology Conference. IMarEST, 2017. http://dx.doi.org/10.24868/bwtc6.2017.005.

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An image cytometer (CYT) for the analysis of phytoplankton in fresh and marine water environments is introduced. A linear quantification of the number of cells over several orders of magnitude of concentrations was observed using cultures of Tetraselmis and Nannochloropsis measured by autofluorescence of the chlorophyll in a laboratory environment. The functionality of the system outside the laboratory was analysed by phytoplankton quantification of samples taken from marine water environment (Dutch Wadden Sea, The Netherlands) and fresh water environment (Lake Ijssel, The Netherlands). The CY
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Wang, Zequn, and Mingyang Li. "Semi-Supervised Deep Learning for High-Dimensional Uncertainty Quantification." In ASME 2020 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2020. http://dx.doi.org/10.1115/detc2020-22204.

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Abstract Conventional uncertainty quantification methods usually lacks the capability of dealing with high-dimensional problems due to the curse of dimensionality. This paper presents a semi-supervised learning framework for dimension reduction and reliability analysis. An autoencoder is first adopted for mapping the high-dimensional space into a low-dimensional latent space, which contains a distinguishable failure surface. Then a deep feedforward neural network (DFN) is utilized to learn the mapping relationship and reconstruct the latent space, while the Gaussian process (GP) modeling techn
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Westfall, Seth, Olivia Sekulich, Wyatt Culler, Stephen Peluso, and Jacqueline O’Connor. "Quantification of Variation in Combustion Instability Amplitude in a Multi-Nozzle Can Combustor." In ASME Turbo Expo 2020: Turbomachinery Technical Conference and Exposition. American Society of Mechanical Engineers, 2020. http://dx.doi.org/10.1115/gt2020-16042.

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Abstract In this work, we quantify the level of variation in unstable combustion oscillation amplitudes and identify the source of this variation in a multi-nozzle can combustor. At conditions where pollutant emissions are reduced, lean-premixed combustors can undergo thermoacoustic instability when pressure and heat release rate oscillations couple. A commonly used method for suppressing instability is fuel staging, which is a method where fuel is unevenly distributed between nozzles in a multi-nozzle combustor. Our work follows others who have characterized the effect of fuel staging on comb
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Solin, Jussi, Jouni Alhainen, Esko Arilahti, Tommi Seppänen, and Wolfgang Mayinger. "Fatigue of NPP Components Simulated by Non-Uniformly Strained Stainless Steel Specimens." In ASME 2019 Pressure Vessels & Piping Conference. American Society of Mechanical Engineers, 2019. http://dx.doi.org/10.1115/pvp2019-93833.

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Abstract Comprehensive experimental research on fatigue performance of niobium stabilized (type 347) steel has revealed beneficial effects of hot holds aimed to simulate normal operation of NPP between the fatigue relevant transients. Reduction of plastic strain, extension of life and increase of endurance limit has been demonstrated in strain controlled HCF tests. Our latest results indicate moderate, but still measurable ‘hold effects’ even without any stop of straining and loading, when blocks of low rate cycles are applied between normal frequency straining at constant 325°C. A new lab tes
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Han, Manbae, Stanislav V. Bohac, Timothy J. Jacobs, and Dennis N. Assanis. "Method and Detailed Analysis of Individual Hydrocarbon Species From Diesel Combustion Modes and Diesel Oxidation Catalyst." In ASME 2007 Internal Combustion Engine Division Fall Technical Conference. ASMEDC, 2007. http://dx.doi.org/10.1115/icef2007-1632.

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An undiluted exhaust hydrocarbon (HC) speciation method, using flame ionization detector (FID) gas chromatographs (GC), is developed to investigate HC species from conventional and low-temperature premixed charge compression ignition (PCI) combustion, from pre- and post-diesel oxidation catalyst (DOC) exhaust. This paper expands on previously reported work by describing in detail the method and effectiveness of undiluted diesel exhaust speciation and providing a more detailed analysis of individual HC species for conventional and PCI diesel combustion processes. The details provided regarding
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Dannert, Mona M., Johannes L. Häufler, and Udo Nackenhorst. "LIMIT REPRESENTATIONS OF IMPRECISE RANDOM FIELDS." In 4th International Conference on Uncertainty Quantification in Computational Sciences and Engineering. Institute of Research and Development for Computational Methods in Engineering Sciences (ICMES), 2021. http://dx.doi.org/10.7712/120221.8024.19110.

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Duan, Zhenzhen, Yangwei Liu, and Lipeng Lu. "Numerical Investigation of the Behavior of Tip Leakage Flow in a Low-Speed Axial Compressor Rotor at Near-Stall Condition." In ASME Turbo Expo 2012: Turbine Technical Conference and Exposition. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/gt2012-69635.

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In the present work, time-accurate simulations were performed to investigate the unsteady flow fields in the tip region of a low-speed large-scale axial compressor rotor at near-stall condition. Firstly, the steady performance characteristic of the rotor was obtained by steady simulations. Secondly, a series of unsteady simulations were carried out to investigate the physical processes as the rotor approaching stall and the role of complex tip flow mechanism on flow instability in the rotor. The characteristics of tip leakage vortex were compared between design condition and near-stall conditi
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