Academic literature on the topic 'Loth, Johann Carl'

Abstract Humabodies* are fully human VH antibody components that can be connected by short peptide linkers to make multi-specific therapeutics. CB307 is a tri-specific Humabody targeting prostate specific membrane antigen (PSMA/FOLH1), CD137 (4-1BB/TNFSF9) and human serum albumin (HSA). Unlike CD3 targeting bispecific compounds, stimulation of CD137 on T cells can promote T cell cytotoxicity, proliferation, survival and memory T cell formation without compromising safety, including cytokine release syndrome (CRS). In addition, HSA binding assists CB307 penetration into the tumor since albumin is enriched in the tumor microenvironment. Several cancers including prostate cancer and lung cancer are known to have PSMA expression. The objectives of the POTENTIA study are to determine the maximum tolerated dose (MTD) and pharmacokinetics of CB307 and to assess preliminary anti-tumor activity in patients with PSMA+ solid tumor. Methods: The phase 1 study consists of dose escalation (part 1) and cohort expansion (part 2) components, and the study is currently enrolling patients in part 1 without dose limiting toxicities (DLTs). The dose escalation uses an accelerated titration design (ATD) and a modified continual reassessment method (mCRM) to guide the MTD and the recommended phase 2 dose (RP2D). The key inclusion criteria are as follows: histologically confirmed advanced or metastatic PSMA expressing solid tumors determined by immunohistochemistry; not amenable to standard-of-care; RECIST measurable disease or increased serum PSA at baseline (for bone metastasis-only prostate cancer). The key exclusion criteria are patients with brain metastases; patients who have discontinued previous immunotherapy due to intolerable immune-related adverse events; patients with acute infections or autoimmune diseases. Cohort expansion uses the same eligibility criteria, however, at least 3 patients with castration-resistant prostate cancer harboring either BRCA1, BRCA2, ATM and/or CDK12 mutation(s) will be enrolled. CB307 is administered intravenously every week. PSMA-PET scan and tumor biopsy are taken to understand the mechanism of action of CB307 as well as a change of PSMA expression during CB307 treatment. NCT04839991 * “Humabody” is a registered trademark ® of Crescendo Biologics Ltd. Citation Format: Johann S. de Bono, Hendrik-Tobias Arkenau, Eelke H. Gort, Lot L. Devriese, Elisa Fontana, Daan G. Knapen, Crescens Tiu, Anja Williams, Derk Jan A. de Groot, Ulug M. Gunaydin, Phillip Bartlett, Andrew J. Pierce, Philip Bland-Ward, Kenji Hashimoto, E.G. Elisabeth de Vries. A phase 1 open-label, dose escalation and expansion trial to investigate the safety, pharmacokinetics and pharmacodynamics of CB307, a Trispecific Humabody® T-cell enhancer, in patients with PSMA+ advanced and/or metastatic solid tumors (POTENTIA) [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr CT207.

The future of the museumsA lot of people worry on behalf of the museums. Museums are boring and dusty, and no one can be bothered to visit them, the young ones not at all, they want adventure, they want int eractive computer games. In a report published jointly by Elsebeth Gerner Nielsen, minister of cultural affairs, and Pia Gjellerup, then minister of commerce, in December 2000, the two ministers decreed that ”it is necessary for Danish economy that the cultural sector – museums, too – begin to think commercially.” If one asks what it takes, the answer is often: ”make the museum s come alive.” A visit to a museum should be an experience similar to a visit to Legoland or Disneyland. We presently see museum leaders anxious about being left behind by the development and feverishly trying to make their museums come alive. Visitors’ centres spring up like mushrooms in the Danish museum landscape, and the National Museum in Copenhagen recently hosted the Missing Link – alive! exhibition, which illustrated the development of humankind through four million years. Here, showcases contained moving robots, interactive elements where the visitors could measure their strength against the Neanderthal Man, compare hands with some of our supposed ancestors, touch copies of tools, answer questions about the development of man etc. – hardly any original material was presented. It is my belief that the idea shared by politicians and some museums – that re-enactment may attract visitors – is utterly unrealistic and that too much attention is paid to a couple of isolated successes.l am not against people having a good time. However, I do not think this an area for the museums to make themselves seriously felt. Other media deal with history coming alive. Historical plays by Shakespeare, Racine, Johann Friedrich Schiller and August Strindberg have been performed a thousand times. People have cried in torrents over the destiny of Anne Frank, they have shivered to witness the brutal murder on Julius Caesar, and they have breathlessly followed the conflict between Charles V and his son, Don Carlos, the governor of the Netherlands, which is described by Schiller in such a spellbinding fashion. Museums will never be able to create anything similar to this, no matter how much they dress the ticket seller or the museum keepers in medieval clothing, and no matter how many monkey tricks are made in the museum cafés in order to serve medieval food and sour ale.Re-enacting the past is not a museum task. Films, theatre, and literature will do that. Still, this does not mean that there is no room for museums. Because the museums have something no one else has. They have things from the past. Most things by far are lost in the course of time, and so it should be. At least that is how it is. Most furniture is worn out and goes to pieces, and the same fate befalls clothes, glasses, shoes, cars, toys, tractors, packing, calculating machines, ladles, anything. Things are perishable; they disappear due to the ravages of time. Items slip away between our hands, just as the time, and much faster than we think. In most homes only a few things are older than fifty years.So, the museums are treasuries that protect the few remaining items for eternity. Only a single pale yellow wrong-coloured Swedish three-shilling stamp from 1855 exists. It is the world’s most expensive stamp, traded in the 1990s for thirty million Dkr. It is depicted in books on stamps, you see it in newspapers, on the Internet, everywhere, but there is only a single original one. It was sold for a fortune, the rest of the millions of reproductions of it have no price – they are used for wrapping up fish, they are me rely copies. The whole truth, the whole authenticity, the radical certainty that in 1855, a Swedish printer by mistake used a three-shilling pr inting plate while printing yellow eightshilling stamps is held within the pushing presence of the original.The aura of authenticity raises the original items to a class by themselves and makes them incomparable to anything else. The real is the trump card of the museums. The more freewheeling flow of pictures, the more monitors and TV-screens that are put up wherever you turn, the more worthless copies, the more tokens are circulated, the larger is the hunger for real things. The museum is the very place where the flow of copies ends, the place where the neverending maelstrom of reproductions is stopped, in the museums there is peace, here the flicker and the noise and absent-minded clicking of the mouse ends, here the world begins. At a time where the monitor replaces reality, museums may satisfy the hunger for the real thing.The de-realisation of reality, the daily encounter with fleeting pictures of things has created a huge demand for meeting the things in themselves. Museums are a countermeasure against the monitors. The museums safeguard the spaciousness and the plasticity, the tangibly existing against the cold immateriality of cyberspace. The truth is concrete, not abstract. If the museums want it, they have a future.The museums are the owners of a marvellous raw material, which on the other hand gives no guarantee of success; it is merely the prerequisite for success – just as the best theat replay does no t guarantee a successful performance. The good exhibition makes it possible to rediscover direction and meaning in a world tortured by fear of the future. If the museums would trust themselves and open their eyes to the immense treasure of original objects that they have at their disposal and not let themselves be seduced by all the talk of the great narrative being lost and everything being hopeless, then they have a great time ahead of them. I for one am not worried.Thorkild KjærgaardNordborgTranslated by Annette Lerche Trolle

Photo by Hush Naidoo Jade Photography on Unsplash INTRODUCTION In this collection of narratives, the authors describe their own experiences with and reflections on healthcare worker vaccine hesitancy. The narratives explore each author’s engagement with different communities experiencing vaccine hesitancy, touching on reasons for hesitancy, proposed solutions, and legal aspects. Author’s names appear above their narratives. l. Johanna T. Crane Vaccine hesitancy, defined as “a delay of acceptance or refusal of vaccination despite the availability of vaccination services,”[1] is a worldwide but locally shaped phenomenon that pre-dates the COVID-19 pandemic.[2] Contrary to some portrayals, vaccine hesitancy is not the same as the more absolute antivaccination stance, or what some call “anti-vax.” Many people who are hesitant are not ideologically opposed to vaccines. Hesitancy is also sometimes framed as anti-science, yet reluctance to vaccinate is often about managing risk, trustworthiness, and doubt in the context of uncertainty; it represents an effort to “talk back to science” about unaddressed needs and concerns.[3] In the US, the newness of the vaccines, the unprecedented speed at which they were developed, and their remaining under emergency use authorization at first complicated public confidence. Political polarization and racial and social inequality shape vaccine acceptance and public distrust as well. While vaccine acceptance has increased in the months since the vaccines first became available, many eligible individuals have not yet been vaccinated, including a significant number of healthcare workers.[4] Vaccine hesitancy among healthcare workers may seem surprising, especially given their frontline experience – I confess that it surprised me at first. But when I began interviewing health care workers for a study on COVID vaccine roll-out at community health centers, I learned to take a more complex view. Although the study was focused on patient vaccine access,[5] many of the frontline health care workers we spoke with also described hesitancy among some of their colleagues (and, in a few cases, themselves). From these conversations, I learned that these “healthcare heroes” are also regular people and members of communities. Their concerns about COVID vaccination often reflect the prevailing concerns advanced in their communities, such as worries about vaccine side effects and safety. Like other workers, some fear missing work and losing income, as not all healthcare employers offer paid time off for vaccination or recovery. (Importantly, reluctance to vaccinate is highest among healthcare workers in lower-paid positions with little job security, such as clerks, housekeepers, patient care assistants, and home health aides.)[6] For some healthcare workers of color, the protection offered by the vaccine sits in tension with both current and historical experiences of medical abuse and neglect. Some interviewees, fully vaccinated themselves, rejected the framework of “hesitancy” entirely, arguing that Black and Brown reluctance to be vaccinated first should be understood through the lens of “self-protection”. Due to the nature of their work, healthcare workers have faced great social pressure to vaccinate and vaccinate first. This is understandable, given that vaccination against COVID-19 protects not only workers themselves but aligns with the ethical duty to prevent harm to patients by reducing the risk of transmission in healthcare settings. When the FDA approved COVID-19 vaccines under emergency use authorization in December 2020, many healthcare workers were extremely grateful to be designated “1a” – the first group prioritized to receive the shots.[7] For many bioethicists, prioritization of healthcare workers represented a recognition of the extreme risks that many front-line workers had endured since the onset of the pandemic, including critical shortages in PPE. But it is important to remember that for some workers, going first may have felt like serving as guinea pigs for new vaccines that had yet to be granted full FDA approval. For these individuals, the expectation that they would vaccinate first may have felt like an additional risk rather than a reward. Healthcare workers who are hesitant to vaccinate may feel ashamed or be subject to shaming by others;[8] this may make it difficult to discuss their concerns in the workplace. Throughout the pandemic, healthcare workers have been lauded as “heroes”, and some healthcare employers have promoted vaccination among their workforce as a “heroic” action. This messaging implies that waiting to vaccinate is shameful or cowardly and is echoed in opinion pieces and op-eds describing unvaccinated people as “selfish” or “free riders.”[9] By fostering the proper dialogue, we can respond respectfully to hesitancy among healthcare workers while still working towards the goal of increased vaccination. We in the bioethics and medical community should be willing to listen to our colleagues’ concerns with respect. Top-down approaches aimed at “correcting” hesitancy cannot address the more fundamental issues of trust that are often at stake. Instead, there must be dialogue over time. Conversations with a trusted healthcare provider have a crucial role.[10] Blaming and shaming rhetoric, whether explicit or implicit, gets us nowhere – in fact, it likely moves us backward by likely exacerbating any existing distrust or resentment that workers may hold toward their employers.[11] Lastly, the onus of trust must be with institutions, not individuals. There is a lot of talk about getting communities of color, and Black people, particularly, to "trust" healthcare institutions and the COVID vaccines. This racializes trust and puts the burden on harmed communities rather than on institutions acting in trustworthy ways.[12] Dialogue, respect, and trustworthiness must guide us even in the new era of workplace mandates. Mandates make these strategies even more important as we look toward an uncertain future. As Heidi Larson, founder of the Vaccine Confidence Project, recently said, “We should not forget that we are making people's future history now. Are people going to remember that they were treated respectfully and engaged?”[13] ll. Kara Simpson Since the release of the vaccine for COVID-19 in late 2020, there have been robust discussions within the medical community, the media, and political arenas about vaccine hesitancy among healthcare workers. The public became aware that healthcare workers, the first group to become eligible for the vaccine, were not rushing to “take the shot.” Many people’s opinions were aligned by race, ethnicity, socioeconomic status, and political affiliation. People of color were one of the first groups to be labeled vaccine hesitant as our experiences of distrust of the medical community and the politicization of the vaccine explained the low turnout.[14] It was not uncommon to hear, “this vaccine just came out; let’s wait and see if there are side effects.” Interestingly, many people in the healthcare community and in the public did not understand why healthcare workers of color remained hesitant. Trust is a vital component of any viable relationship, especially in the clinical realm. To have successful health outcomes, it is essential for clinicians to build trusting relationships with their patients and peers. Many people of color are distrustful towards the medical institution due to the years of systemic racism and abuses that they have experienced, witnessed, or learned about. Healthcare workers of color are not excluded from the experiences of their communities outside of work. In fact, I assert that healthcare of color may have an additional burden of hesitation because of their lived experiences of distrust in receiving care and inequality within their professional environment. These dual traumas can work in tandem to strengthen hesitancy. I assert that building trusting clinical relationships will address hesitancy over time. Currently, many healthcare workers are worried about vaccine mandates. For a group of people that have experienced intergenerational enslavement and marginalization, mandates feel coercive and serve as a reminder of how “lesser” bodies are considered unworthy of voice, fundamental human rights, independent decision making. To call the vaccine mandate paternalistic would be an understatement. An unintended result of vaccine mandates will be the reinforcement of hesitancy and distrust of the medical institution as trust and coercion cannot coexist. This mandate will give more power to the conspiracy theories and harm those who already do not seek or receive adequate health care because of systemic inequalities. Furthermore, mandates can also dissuade people of color from becoming healthcare workers, and others may leave the field. In essence, vaccine hesitancy is a symptom of a much larger problem: the distrust of the medical establishment. As bioethicists, our mission should be to support interventions that foster “trustworthiness” of the institutions rather than those that cause trauma. Several organizations have proposed mask mandates and weekly testing as a measure to protect the population at large and still respect the autonomy of the unvaccinated.[15] lll. Jennifer Breznay I work in a very large community teaching hospital in Brooklyn, and we were extremely hard hit by COVID in March 2020. I worked on inpatient medical units and witnessed a lot of suffering. And after nine months of fear and despair about COVID’s toll, I felt tremendous frustration in December when I heard that many healthcare workers would reject the vaccine. As the co-chair of the Bioethics Committee, I drafted a statement recommending vaccination for all employees. When the draft was revised and approved by the Bioethics Committee, I began to discuss it with employees, and I appreciated different perspectives I had not heard before. In the end, rather than releasing the statement, we directed our efforts at creating a dialogue. I also volunteer at a not-for-profit which operates seven early childhood education centers in Northern Brooklyn. The Executive Director invited me to collaborate on strategies to encourage staff vaccination, and we decided to offer a Zoom conference to 20 members of the staff. I was extremely nervous about how the audience would perceive me, a white doctor whom they did not know. I felt awkward about coming to them with an agenda. And there was also the question of whether I was an appropriate messenger compared to a person of color. Yet, I felt like I shouldn't back away from this. So, I chose to simply disclose my discomfort at the beginning of the Zoom. I said, “Thanks for having me. You know, as a white physician, I understand you might have concerns about trusting what I say. Four hundred years of inequity and abuse by the healthcare system can create a lot of mistrust, but I’m here to try to answer your questions.” Ultimately the Executive Director reported that the Zoom was successful in stimulating a lot of conversation among the staff about the vaccine. I think the critical piece is the intimate but open conversation, where you can elicit values. lV. Ashley L. Stewart In the rural areas of our state, healthcare institutions are inextricably tied to their communities. Rural hospitals hire from, serve, and function in the community where they are located. Successful implementation of a vaccine roll-out in such rural areas requires explicit recognition of the role and influence of the community. After identifying issues common to the area, rural institutions can address them. Even when rural institutions find that healthcare worker concerns seem to be unique or personal, they are often related to the larger concerns of the community.[16] Community-based increased vaccine hesitancy may coincide with an underlying issue, such as lack of information rather than principled or experience-based resistance.[17] When the vaccines became available, rural vaccination coordinators encountered a wealth of misinformation that left many people initially undecided. Compounding this lack of information, workers expressed a sense of fear about the professional consequences of voicing concerns, especially in tight-knit communities. Many workers expressed concern about being judged merely for sharing their questions or decisions.[18] They also felt that saying or doing something to promote the value of vaccination might change their relationship with members of the community where they live and work.[19] As there was a fear of engaging in productive conversations, it was difficult for them to find valuable information, and the lack of information discouraged them from being vaccinated. Vaccine coordinators wanted to get information to the entire community based on the most current research and release unbiased, consistent, and timely information from sources all people in the community could trust, including from multiple sources at once. Communication must focus on answering many types of questions, which must often be done in private or anonymously. Where poorly supported or incorrect information is widely available, sharing objective information is crucial to turning the tide of distrust. If the healthcare community dismisses concerns or assumes that answering questions based on misinformation is a waste of time, the community-based institutions will further the distrust. Some may feel that vaccine coordinators should not address misinformation directly, yet avoidance has been widely unsuccessful.[20] Being respectful and non-judgmental in answering questions posed by people who do not know what is true can be hard, but in rural communities, answering completely and honestly without judgment is a critical component of any effort to inform people. Telling people to get vaccinated “for the greater good” can sound the same as being told not to get a vaccine because it is “bad” if both sources of information fail to back up their claims. Ultimately rural institutions are respected because they are a resource to their communities, a priority we must preserve. It is also critical to treat everyone respectfully regardless of vaccine status.[21] People may perceive mandates, divisive policies, or disrespectful treatment of people based on vaccination status as discriminatory or coercive, weakening the appeal of vaccination. Such practices may make people less trusting and more anchored to their position as they come to see vaccination proponents as untrustworthy or authoritarian. We must work to maintain respect for human autonomy. Using unethical means to achieve even a just end will not lead to a “greater good” but rather to the perception that people in positions of authority would achieve a result “by any means necessary.” V. David N. Hoffman The central moral quandary that arises whenever vaccine hesitancy among healthcare workers is discussed is whether workers who refuse to get vaccinated should or could be fired. We should clarify that we are applying a definition of mandate in the employment context for private employers, the violation of which results in loss of employment. Government-controlled provider organizations are just now weighing in on this topic and are generally pursuing strategies that impose periodic, usually weekly, testing requirements for those workers who decline to get vaccinated. In the private sector, employers can require their employees to do a great many things as a condition of employment, and one of them is to get vaccinated against COVID -19. In the most prominent case to date, just such a mandate gave rise to a lawsuit in Texas involving Houston Methodist Hospital. In that case, 170 employees asserted that an employer should not be allowed to force them to get vaccinated. The judge held that, while no employer can force an employee to get vaccinated, no employer is obligated to continue the employment of any employee who declines to follow rules established by that employer, including the obligation to get vaccinated.[22] In Texas, what the judge said is you are not being forced to get vaccinated, but your employer is allowed to set limits and conditions on employment, including vaccination. Employees do not have an obligation to get vaccinated, but they also have no right to their jobs. That is because of a widely misunderstood legal concept: “employment at will.” Employment at will sounds like a rule that employees can do what they want at work, but in fact, employment at will means only that you can quit your job whenever you want (we do not permit indentured servitude). At the same time, your employer can fire you at any time, for any reason or no reason, unless the reason is a pretext and involves one of the protected statuses (race, color, religion, sex, or national origin, and in some jurisdictions gender orientation, gender identity). Generally, any employers, including hospitals, can decide that if someone is not willing to get a vaccination, or if they are not willing to complete sexual harassment training or participate in the hospital’s infection control program, that is the employee’s right, but it will mean that an employer can similarly decline to continue providing employment. The evolution of this hesitancy discussion will be influenced by the narrower debate playing out in the court of public opinion, and the courts of law, over the enforceability of New York’s recently enacted vaccine mandate. Regardless of whether that mandate survives, with or without medical and religious exemptions, healthcare employers will be left with a profound ethical dilemma. At the end of all the litigation, if there is a religious exemption, employers will always be burdened with the responsibility to determine whether an individual employee has asserted a genuine and sincere religious objection to vaccination and whether the employer is able to provide an accommodation that is safe and effective in protecting the interests of co-workers and patients. The anticipated federal mandate, which reportedly will have a test/mask alternative, will only make this ethical task more challenging. This leads to the final point in this analysis, which is that while private employers, including hospitals, can deprive an individual of their employment if those individuals refuse to get vaccinated, just because an employer can do so does not mean it should do so.[23] - [1] MacDonald NE. Vaccine hesitancy: Definition, scope and determinants. Vaccine. 2015;33(34):4161-4164. doi:10.1016/j.vaccine.2015.04.036 [2] Larson HJ, de Figueiredo A, Xiahong Z, et al. The State of Vaccine Confidence 2016: Global Insights Through a 67-Country Survey. EBioMedicine. 2016;12:295-301. doi:10.1016/j.ebiom.2016.08.042 [3] Larson H. Stuck: How Vaccine Rumors Start - and Why They Don’t Go Away. Oxford University Press; 2020; Benjamin R. Informed Refusal: Toward a Justice-based Bioethics. Sci Technol Hum Values. 2016;41(6):967-990. doi:10.1177/0162243916656059 [4] Deepa Shivaram, In The Fight Against COVID, Health Workers Aren't Immune To Vaccine Misinformation September 18, 2021. NPR Special Series: The Coronavirus. https://www.npr.org/2021/09/18/1037975289/unvaccinated-covid-19-vaccine-refuse-nurses-heath-care-workers [5] Crane JT, Pacia D, Fabi R, Neuhaus C, and Berlinger N. Advancing Covid vaccination equity at Federally Qualified Health Centers: A rapid qualitative review. Accepted and awaiting publication at JGIM. [6] Ashley Kirzinger. “KFF/The Washington Post Frontline Health Care Workers Survey - Vaccine Intentions.” KFF, 22 Apr. 2021, https://www.kff.org/report-section/kff-washington-post-frontline-health-care-workers-survey-vaccine-intentions/. [7] Johanna Crane, Samuel Reis-Dennis and Megan Applewhite. “Prioritizing the ‘1a’: Ethically Allocating Scarce Covid Vaccines to Health Care Workers.” The Hastings Center, 21 Dec. 2020, https://www.thehastingscenter.org/prioritizing-the-1a-ethically-allocating-covid-vaccines-to-health-care-workers/. [8] “'I'm Not an Anti-Vaxxer, but...' US Health Workers' Vaccine Hesitancy Raises Alarm.” The Guardian, Guardian News and Media, 10 Jan. 2021, https://www.theguardian.com/world/2021/jan/10/coronavirus-covid-19-vaccine-hesitancy-us-health-workers. [9] Gerson M. If you are healthy and refuse to take the vaccine, you are a free-rider. Washington Post. April 15, 2021. [10] Crane JT, Pacia D, Fabi R, Neuhaus C, and Berlinger N. Advancing Covid vaccination equity at Federally Qualified Health Centers: A rapid qualitative review. Accepted and awaiting publication at JGIM. [11] Larson H. Stuck : How Vaccine Rumors Start - and Why They Don’t Go Away. Oxford University Press; 2020. [12] Benjamin R. Race for Cures: Rethinking the Racial Logics of ‘Trust’ in Biomedicine. Sociology Compass. 2014;8(6):755-769. doi:10.1111/soc4.12167; Warren RC, Forrow L, David Augustin Hodge S, Truog RD. Trustworthiness before Trust — Covid-19 Vaccine Trials and the Black Community. N Engl J Med. Published online October 16, 2020. doi:10.1056/NEJMp2030033 [13] Offri D. Heidi Larson, Vaccine Anthropologist. New Yorker. Published online June 12, 2021. Accessed August 11, 2021. https://www.newyorker.com/science/annals-of-medicine/heidi-larson-vaccine-anthropologist [14] Razai M S, Osama T, McKechnie D G J, Majeed A. Covid-19 Vaccine Hesitancy Among Ethnic Minority Groups. BMJ 2021; 372 :n513 doi:10.1136/bmj.n513 [15] Dasgupta, Sharoda, et al. “Differences in Rapid Increases in County-Level COVID-19 Incidence by Implementation of Statewide Closures and Mask Mandates — United States, June 1–September 30, 2020.” Annals of Epidemiology, vol. 57, Sept. 2021, pp. 46–53., https://doi.org/10.1016/j.annepidem.2021.02.006. [16] Do, Tuong Vi C et al. “COVID-19 Vaccine Acceptance Among Rural Appalachian Healthcare Workers (Eastern Kentucky/West Virginia): A Cross-Sectional Study.” Cureus vol. 13,8 e16842. 2 Aug. 2021, doi:10.7759/cureus.16842; Danabal, K.G.M., Magesh, S.S., Saravanan, S. et al. Attitude towards COVID 19 vaccines and vaccine hesitancy in urban and rural communities in Tamil Nadu, India – a community-based survey. BMC Health Serv Res 21, 994 (2021). https://doi.org/10.1186/s12913-021-07037-4 [17] Scott C. Ratzan MD, MPA, MA, Lawrence O. Gostin JD, Najmedin Meshkati PhD, CPE, Kenneth Rabin PhD & Ruth M. Parker MD (2020) COVID-19: An Urgent Call for Coordinated, Trusted Sources to Tell Everyone What They Need to Know and Do, Journal of Health Communication, 25:10, 747-749, DOI: 10.1080/10810730.2020.1894015 [18] Huang, Pien. “Some Health Care Workers Are Wary of Getting COVID-19 Vaccines.” NPR, NPR, 1 Dec. 2020, https://www.npr.org/sections/health-shots/2020/12/01/940158684/some-health-care-workers-are-wary-of-getting-covid-19-vaccines. Portnoy, Jenna. “Several Hundred Virginia Health-Care Workers Have Been Suspended or Fired over Coronavirus Vaccine Mandates.” The Washington Post, WP Company, 4 Oct. 2021, https://www.washingtonpost.com/local/covid-vaccine-mandate-hospitals-virginia/2021/10/01/b7976d16-21ff-11ec-8200-5e3fd4c49f5e_story.html. [19] Jennifer A. Lueck & Alaina Spiers (2020) Which Beliefs Predict Intention to Get Vaccinated against COVID-19? A Mixed-Methods Reasoned Action Approach Applied to Health Communication, Journal of Health Communication, 25:10, 790-798, DOI: 10.1080/10810730.2020.1865488 [20] Lockyer, Bridget, et al. “Understanding Covid-19 Misinformation and Vaccine Hesitancy in Context: Findings from a Qualitative Study Involving Citizens in Bradford, UK.” Health Expectations, vol. 24, no. 4, 4 May 2021, pp. 1158–1167., https://doi.org/10.1101/2020.12.22.20248259. Scott C. Ratzan & Ruth M. Parker (2020) Vaccine Literacy—Helping Everyone Decide to Accept Vaccination, Journal of Health Communication, 25:10, 750-752, DOI: 10.1080/10810730.2021.1875083. [21] Zimmerman, Anne. Columbia Academic Commons, 2020, Toward a Civilized Vaccination Discussion: Abandoning the False Assumption That Scientific Goals Are Shared by All, https://academiccommons.columbia.edu/doi/10.7916/d8-rzh0-1f73. [22] Bridges, et al v. Houston Methodist Hospital et al, https://docs.justia.com/cases/federal/districtcourts/texas/txsdce/4:2021cv01774/1830373/18 [23] David N. Hoffman, “Vaccine Mandates for Health Care Workers Raise Several Ethical Dilemmas,” Hasting Center Bioethics Forum. August 2021. https://www.thehastingscenter.org/vaccine-mandates-for-health-care-workers-raise-several-ethical-dilemmas/

Contemporary definitions of resilience stress adaptability to changing ecological and economic conditions (Berkes, Colding and Folke; Castleden, McKee, Murray and Leonard 369). But this approach to resilience is a measure of individual ‘fitness’ to an adaptive whole (Hughes 165; McMahon et al.; Walker and Cooper). Not only is this incongruous with the experience of reproductive loss and infertility, it also works to sideline alternative forms or sources of resilience (Cox). In this paper, we share our efforts to build on previous theories of resilience by engaging in intimate dialogues and written reflections about our personal experiences with reproductive loss. Throughout the paper our reflections are interspersed with our ‘findings’ about the relationship between reproduction and resilience. For us, an active process of dialogically grounded reflection opened up the possibility of a different type of theoretical engagement, one that ultimately produced different enactments, and offered unexpected redirections, both of our experience with reproductive resilience, and in the resilience literature at large. This deeply personal, dialogical frame allowed us to move beyond the anecdotal and confessional to encompass a praxis that engaged the acutely affective reality of reproductive resiliency. Katherine: Three years ago, in the wake of the global financial crisis, I became interested in growing references to resilience in the media. I decided to start a graduate reading group on this theme. This was 'serious academic work.' We looked at questions like: Why has the UNDP rebranded itself 'Empowered Lives, Resilient Nations'? But my thinking about resilience was interrupted by a personal crisis. In January 2011, I was surprised and delighted to discover I was pregnant after years of clinically diagnosed 'unexplained infertility.' So my husband and I were devastated when, in May, a medical crisis (for me, not the baby) forced us to abort the pregnancy in its fifth month. Two years of exhausting medical interventions later, I learned that I am unable to bear children of my own—unable to reproduce—a fact which I am still actively struggling to reconcile. Ayumi: Strange the surprising state of affairs that would shift an employer and research lead into an acquaintance, confidante and friend. I initially learned of her challenges to carry a child to full term through proximity. As her teaching assistant I felt obliged to inform her that I had recently experienced an early miscarriage, and that it could possibly disrupt my work in her course. She was visibly pregnant at the time. Soon after, when I was participating in the resilience reading group, she miscarried as well. Reproductive Resilience A year or more passed before we spoke to each other about our losses, but when we did, we realised that we had both been influenced by dominant discourses around reproduction. Identifying the source of these pressures was an important topic of reflection for us. We found that dominant conceptions of reproductive resilience are overshadowed by a biological imperative to reproduce. When a woman is unable to conceive, or experiences a reproductive loss, she is told to ‘try again.’ There can be solace in trying, and in the ‘successful’ cases, a ‘happy resolution’ is achieved in subsequent pregnancies. But in other cases, the woman's body must produce several reproductive losses before medical professionals can understand the causes of her inability to reproduce (McMahon et al. 2007; Sexton, Byrd, and von Kluge 236). A series of increasingly invasive medical interventions can then be employed to increase the likelihood of reproduction. As a biological imperative, this type of reproductive resilience demands “progressive adaptation to a continually reinvented norm” (Walker and Cooper 156) of what it means to be fertile. But this is more than just a medical norm. Increasingly, reproduction also implies “adaptability to extremes of [ecological and economic] turbulence” (ibid.) that establish the conditions in which fertility is both experienced and understood, something that Katherine in particular had faced: Katherine: Why is it that we both ended up in this situation? Why is it that we are far from being alone in being 40 and childless? I am partly a product of the 1980s teen pregnancy hysteria in North America which made it an anathema for young women to ‘jeopardise’ their earning potential by having children. This makes me particularly bitter because I now understand that, at that moment in history, my society decided to prioritise my productive contributions to capital over socialised financing of the conditions that would allow me to produce a family. What I am suggesting is that the discourses which produce the preconceived notions that we attempt to ‘live up to’ are also discourses that we must, in many ways, ‘live with,’ because like it or not, they contributed to producing the situation which is now prompting us to write this paper! In this sense, reproductive resilience also becomes a measure of normalcy, where normalcy includes the adaptability of human bodies and biological process to the demands of a socio-economic system. Reproductive loss or infertility then becomes a source of personal weakness or abnormality that must be overcome, and a cause of personal degradation, which is often kept silent. In our experience, although individual responses differed greatly, either way the failure to reproduce demanded a response: Katherine: After my loss, I became determined to be pregnant again. For me IVF treatments were not so much about wanting to know with certainty my bodily ability to bring a child into the world. I was working under the perhaps rather desperate assumption that they would. I think of my IVF year more as desperation to achieve an end, a fear of failure, a crisis of sustainability, and a disbelief or disassociation from my own physical reality—the fact of my advancing age. The idea of ‘self-enclosed bodily anxiety’ captures this wonderfully for me. Ayumi: I did nothing, not a single consultation with a fertility expert, no visits to herbal medicine specialists, at most, a half-hearted internet search on adoption agencies. My path insisted upon embracing uncertainty over entrusting others with telling me the limits of my bodily integrity. When we began to share our stories with each other, we noticed that, despite having been surrounded by loving families and supportive colleagues at our times of crisis, both of us felt a tremendous sense of isolation as we tried to make sense of and respond to our losses. So a second area of reflection concerned the source of these emotions—both the sense of isolation, and the way in which it reinforced the normalisation of dominant discourses of reproductive resilience. We found that the reproductive industry’s medical interventions and specialised language community codify and reinforce measures of normalcy and sustain a coerced and often isolating process of adaptation to ever-more medicalised norms of fertility (Bonanno 753). This isolation is particularly apparent for women who choose to pursue fertility treatments. The language of medical intelligence is overwhelming and difficult to learn, creating a barrier between insiders and outsiders to fertility interventions (see for example: Kagan et al., S151). Fertility treatments are not only highly technical, but also a very introspective process, making it difficult for fertility partners, let alone friends and family, to fully comprehend what is going on, or to be involved. Meanwhile, support is difficult to find in a fertility clinic’s waiting room at 7am where groups of women silently await blood work to monitor hormone levels, avoiding eye contact by scanning their phones or reading a magazine. Many women turn instead to online forums, such as www.ivf.ca, where there is mutual comprehension wrapped in the security of anonymity. Rather than explain themselves each time they post to a forum, participants take up the language of reproductive medicine to detail their reproductive interventions in codified signature files (see Figure 1 below). Here, lengthy fertility campaigns become a merit badge of adaptability and perseverance. In their messages, participants share jingoistic mantras like ‘It only takes one!’, one harvested egg to have a child, as they cheer each other on in the search for a baby (Figure 2 below). These types of forums can empower insofar as they educate and encourage. However, they can also enclose and isolate as they cut patients off from family and friends, while creating external pressure to achieve a biological imperative suspended in changing parameters for what it means to be fertile. Figure 1: Example of a Signature File from an IVF Discussion Forum Figure 2: “It only takes one!” This kind of isolated adaptation to medicalised norms of fertility can come at a very high cost. For example, one friend was so traumatised by the multiple fertility interventions and failures it took for her to bear a child that she was ultimately unable to connect with the baby that she bore. The forward march of fertility treatments under the mounting pressure of advancing age required her to defer mourning for the multiple losses that she was experiencing: the loss of a child, the loss of normalcy, the loss of voice. She alone sustained the physical and psychological weight of reproductive resilience, and the pressures of achieving a ‘good outcome’ within the biological limits of her fertility window. When her daughter was born, she was engulfed by an avalanche of backlogged emotions—years of accumulated grief and stress. She was eventually diagnosed with post-traumatic stress disorder, and has struggled to develop a meaningful relationship with her child. But we also found that one need not pursue fertility treatments to experience the isolating and normalising effects of dominant conceptions of fertility. Some experienced infertility without feeling the need to consult medical professionals, or discover through initial consultations that a commercial and medicalised system was not the means through which they wanted to create a future for themselves. Others could find it difficult to contemplate the ‘reproduction’ of a ‘family’ when past experiences with family had been difficult. Yet, despite these decisions, changing norms of fertility continued to reinforce the biological imperative of reproduction in ways that become interwoven with tacitly heteronormative conceptualisations of the nature of family and community (Peters, Jackson, & Rudge 132-134). Katherine: Just the other day at the community garden, one of the gardeners, whom I had just met, wanted to know whether I had any children. When I said no, he bluntly asked me, ‘Why not?’ Just like that: ‘Why not?’ How can I even begin to answer this question? I’ve started to look people squarely in the eye and say, ‘I guess I must not be blessed.’ It’s not because I think I’m not blessed—my life is incredibly rewarding. It’s because it’s the best way I can think of to point out how inappropriate that line of questioning is. But I guess it’s also a defence… Ayumi: I do find that there is something deeply gendered and heterosexist about that line of questioning. As if there is some type of biological expectation for women to reproduce as a means to complete the family. And in absentia, in not raising the biological imperative with same-sex couples—in particular men, a whole host of assumptions are built into forming a good family. It’s like a double disrespect. In the first instance, the biological imperative falls on women, and in the second instance, the lack of expectation leaves many others out of the conversation. In total, we found that resilience always came with a modifier; otherwise we were left asking ‘resilience of what?’ ‘Resilience for what?’ Economic resilience, for example implied the adaptability of the capitalist system. Similarly, rather than expanding choices for and beyond women, the reproductive industry reinforced the normalcy of a gendered biological imperative that ultimately rested on the shoulders of an isolated individual. “The criteria of selection may well have shifted. Yet in the last instance, and for all its flexibility, the resilience perspective is no less rigorous in its selective function than Darwinian evolution” (Walker and Cooper 156). Dialogue Ayumi: To my surprise, she wanted to talk about it one day when we went for lunch, as though words would form the reality of her unexpected shift from pregnant to not-pregnant. The psychological experience of my own miscarriage had been devastating, so invisible, unannounced. Only those who needed to know were privy to the situation. Perhaps I quietly believed that if I spoke very little of it, it could almost have been mistaken for nothing other than conjecture or wishful thinking. Our conversation reproduced the reality of my failure to carry my child into childbirth. Her request for an empathetic listener would mean that a solitary introspection to resignify respect for my own body would give way to responding with due respect for her becoming no longer pregnant. Dialogue did more than just allow us to make sense of what we were experiencing. In conversation, reproductive resilience became something other than what we experienced in isolation. As experiences transformed into words, one perspective intermingled with and shaped the other, revealing imaginings that undid the closures and conclusions reached in our own minds, and offered an opportunity to reconsider the expectations of dominant narratives. Other possibilities surrounded, awaited contemplation, discursive engagement, solicitude in the shadows of experiences that coincided and diverged, resting assured that points of disagreement could be articulated as conjecture, wordless acknowledgement or future interactions. Our very different experiences and choices formed a context for conversation. We asked of one another: Why did this happen? How do you relate to your body? What do you feel is expected of you? What do you plan to do now? Upon dialogical reflection, it became clear that bodies, rather than being intentional enactments of adaptation, were more often than not products and reproductions of experiences and discourses: Ayumi: What kinds of biological, familial, technological, and economic imperatives are pressed upon our bodies? I wonder too about the ways in which consumerisation of reproduction plays upon our imagination of what it would be like to be a parent, creating a market and psychological demand for this life-changing acquisition of a human life. Perhaps these imperatives are operationalised as different mediations on the body, which is seen as a passive recipient of these directives. The externalisation and internalisation of our thoughts allowed us to see how our knowledge was suspended between our relationship with our body and the, often unexpressed, expectations of others which were based on their unexamined assumptions of what it meant to be a woman, a sexual being, a member of a family, a contributor to the community. Thinking about the body as something performed allowed us to use words to make real, reflect on, reproduce or recast our experiences: Katherine: I’m so independent, even in my relationship with my husband that I was a bit shocked at how my miscarriage rippled through my networks of friends, colleagues and family. People I hardly knew told me that they cried when they heard! I forget sometimes that my husband also suffered a huge loss, a blow to his identity and confidence, and a challenge to his sense of place. It is not just me who needs to engage with questions of resilience, but so does he, and we also need to do that together, and these processes will ripple through our networks of friends, family and co-workers in ways that affect the overall resiliency of a community of people. Ayumi: I talked to my partner about how deep down sometimes I feel that I've already done my work as a caregiver. I did a lot of volunteer and paid work with children when I was younger. I’ve taken care of so many children who ranged dramatically in age, mental and physical health and mobility, children who were dying and then died, and this took up so much of my teens, twenties and early thirties. I told him that while I've had that experience, he hasn't spent so much time with kids so that I wished for him to think about if this was something he wanted to explore (taking on a care giving / parental role), considering the options that are available to us through adoption or fostering. In dialogue, we figured out how to talk to one another, to locate a sense of fun within urgency, to reach toward mutual understanding, to test borders and to reshape them. Putting experiences and expectations into words allowed us to uncover expansive possibilities—options not considered, courses not taken. Ultimately, we began to think of reproductive resilience not as the means to achieve a biological imperative, but rather as a relational space of production. As we exchanged ideas, we came to question the assumption that reproductive resilience could be channeled through an individual body, and consequently we began to push back on definitions of fertility which served as measures of ‘fitness’ to a mythical adaptive whole. Through dialogue we resignified our individualised and isolated experiences with reproduction, turning what we experienced as vulnerability into a starting point for the reconceptualisation of resilience. This process—we call it ‘resiliency’ to distinguish it from adaptation—became an act of occupying our own reality in and through the relationships that surround us. Whereas resilience was about individual adaptations to shifting but still dominant norms of fertility, resiliency was about negotiating and constituting a fertile world through dialogues: Ayumi: I found our discussion of care a vitalising part of our conversations. Somehow, through forging different relations, the body propels resilience toward resisting external reinforcements to individualise reproduction and calls forth a collective response. Katherine: Today we discussed reproduction as a process of constructing a caring condition. Caring both in the sense of nurturing, but also in the sense of consideration. This was the most personally enriching part of our discussion – I felt empowered to make decisions about how I wanted to engage in caring and nurturing. This opened my mind to the possibility of adoption, but also to the fact that I express myself as a caring being in many other ways. Resiliency suggests actively engaging people and forces in ways that do not impose a certain order or state of affairs. But we struggled to think about how this new vision of reproductive resiliency would articulate with resistance. What does it mean to resist when biological failure renders acceptance of reproductive decline the only possible way forward? Though we can resist the conditions that created our current situations, we cannot resist our own pasts or our own biological reality. Should our inability to reproduce be seen as a victory in the fight against material myths of parental bliss? Or does our inability to reproduce make us the martyrs of the post-modern and neoliberal era? We want reproductive resiliency to offer a different experience of fertility. But we also want it to be a foundation to resist the normalisation of biological adaptation to the demands of a turbulent socio-economic system. We can do this by making a distinction between the biological act of reproduction (producing a baby), and the social reproducibility of care (nurturing, engaging, resisting, being, sharing, performing, etc.). Reproductive resiliency is concerned with nurturing the fertile enactments of human caring. It is on the basis of human caring that we can resist a system that creates the need for fertility adaptations, and it is also on this basis that we can open up room for thinking about reproductive resiliency in a respectful and socially engaged way. References Berkes, Fikret, Johan Colding and Carl Folke. “Introduction.” Navigating Social-Ecological Systems: Building Resilience for Complexity and Change. Ed. F. Berkes, J. Colding and C. Folke. Cambridge, U.K.: Cambridge University Press, 2002. Bonanno, George A. “Uses and Abuses of Resilience Construct: Loss, Trauma, and Health-Related Adversities. Social Science & Medicine 74.5 (2012): 753-756. Castleden, Matthew, Martin McGee, Virginia Murray & Giovanni Leonard. “Resilience Thinking in Health Protection. Journal of Public Health 33.3 (2011): 369-377. Cox, Pamela. “Marginalized Mothers, Reproductive Autonomy, and Repeat Losses to Care.” Journal of Law and Society 39.4 (2012): 541—561. Herrman, Helen, et al. “What Is Resilience?” Canadian J. of Psychiatry 56.5 (2011): 258-265. Hughes, Virginia. “The Roots of Resilience.” Nature 490 (2012): 165-167. Kagan, et al. “Improving Resilience among Infertile Women: A Pilot Study.” Fertility & Sterility 96.3 (2011): S151. McMahon, Catherine A., Frances L. Gibson, Jennifer L. Allen and Douglas Saunders. “Psychosocial Adjustment during Pregnancy for Older Couples Conceiving through Assisted Reproductive Technology.” Human Reproduction 22.4 (2007): 1168-1174. Peters, Kathleen, Debra Jackson, and Trudy Rudge. “Surviving the Adversity of Childlessness: Fostering Resilience in Couples.” Contemporary Nurse 40.1 (2011): 130-140. Sexton, Minden B., Michelle R. Byrd, and Silvia von Kluge. “Measuring Resilience in Women Experiencing Infertility Using the CD: RISC: Examining Infertility-Related Stress, General Stress, and Coping Styles.” Journal of Psychiatric Research 44.4 (2010): 236-241. Walker, Jeremy, and Melinda Cooper. “Genealogies of Resilience: From Systems Ecology to the Political Economy of Crisis Adaptation.” Security Dialogue 14.2 (2011): 143-160.

During the War on Terror, the United States military has been conducting an increasing number of foreign campaigns by remote control using drones—also called unmanned aerial vehicles (UAVs) or remotely piloted vehicles (RPVs)—to extend the reach of military power and augment the technical precision of targeted strikes while minimizing bodily risk to American combatants. Stationed on bases throughout the southwest, operators fly weaponized drones over the Middle East. Viewing the battle zone through a computer screen that presents them with imagery captured from a drone-mounted camera, these combatants participate in war from a safe distance via an interface that resembles a video game. Increasingly, this participation takes the form of targeted killing. Despite their relative physical safety, in 2008 reports began mounting that like boots-on-the-ground combatants, many drone operators seek the services of chaplains or other mental health professionals to deal with the emotional toll of their work (Associated Press; Schachtman). Questions about the nature of the stress or trauma that drone operators experience have become a trope in news coverage of drone warfare (see Bumiller; Bowden; Saleton; Axe). This was exemplified in May 2013, when former Air Force drone pilot Brandon Bryant became a public figure after speaking to National Public Radio about his remorse for participating in targeted killing strikes and his subsequent struggle with post-traumatic stress (PTS) (Greene and McEvers). Stories like Bryant’s express American culture’s struggle to understand the role screen-mediated, remotely controlled killing plays in shifting the location of combatants’s sense of moral agency. That is, their sense of their ability to act based on their own understanding of right and wrong. Historically, one of the primary ways that psychiatry has conceptualized combat trauma has been as combatants’s psychological response losing their sense of moral agency on the battlefield (Lifton).This articleuses the popular science fiction novel Ender's Game as an analytic lens through which to examine the ways that screen-mediated warfare may result in combat trauma by investigating the ways in which it may compromise moral agency. The goal of this analysis is not to describe the present state of drone operators’s experience (see Asaro), but rather to compare and contrast contemporary public discourses on the psychological impact of screen-mediated war with the way it is represented in one of the most influential science fiction novels of all times (The book won the Nebula Award in 1985, the Hugo Award in 1986, and appears on both the Modern Library 100 Best Novels and American Library Association’s “100 Best Books for Teens” lists). In so doing, the paper aims to counter prevalent modes of critical analysis of screen-mediated war that cannot account for drone operators’s trauma. For decades, critics of postmodern warfare have denounced how fighting from inside tanks, the cockpits of planes, or at office desks has removed combatants from the experiences of risk and endangerment that historically characterized war (see Gray; Levidow & Robins). They suggest that screen-mediation enables not only physical but also cognitive and emotional distance from the violence of war-fighting by circumscribing it in a “magic circle.” Virtual worlds scholars adopted the term “magic circle” from cultural historian Johan Huizinga, who described it as the membrane that separates the time and space of game-play from those of real life (Salen and Zimmerman). While military scholars have long recognized that only 2% of soldiers can kill without hesitation (Grossman), critics of “video game wars” suggest that screen-mediation puts war in a magic circle, thereby creating cyborg human-machine assemblages capable of killing in cold blood. In other words, these critics argue that screen-mediated war distributes agency between humans and machines in such a way that human combatants do not feel morally responsible for killing. In contrast, Ender’s Game suggests that even when militaries utilize video game aesthetics to create weapons control interfaces, screen-mediation alone ultimately cannot blur the line between war and play and thereby psychically shield cyborg soldiers from combat trauma.Orson Scott Card’s 1985 novel Ender’s Game—and the 2013 film adaptation—tells the story of a young boy at an elite military academy. Set several decades after a terrible war between humans and an alien race called the buggers, the novel follows the life of a boy named Ender. At age 6, recruiters take Andrew “Ender” Wiggin from his family to begin military training. He excels in all areas and eventually enters officer training. There he encounters a new video game-like simulator in which he commands space ship battalions against increasingly complex configurations of bugger ships. At the novel’s climax, Ender's mentor, war hero Mazer Rackham, brings him to a room crowded with high-ranking military personnel in order to take his final test on the simulator. In order to win Ender opts to launch a massive bomb, nicknamed “Little Doctor”, at the bugger home world. The image on his screen of a ball of space dust where once sat the enemy planet is met by victory cheers. Mazer then informs Ender that since he began officer training, he has been remotely controlling real ships. The video game war was, "Real. Not a game" (Card 297); Ender has exterminated the bugger species. But rather than join the celebration, Ender is devastated to learn he has committed "xenocide." Screen-mediation, the novel shows, can enable people to commit acts that they would otherwise find heinous.US military advisors have used the story to set an agenda for research and development in augmented media. For example, Dr. Michael Macedonia, Chief Technology Officer of the Army Office for Simulation, Training, and Instrumentation told a reporter for the New York Times that Ender's Game "has had a lot of influence on our thinking" about how to use video game-like technologies in military operations (Harmon; Silberman; Mead). Many recent programs to develop and study video game-like military training simulators have been directly inspired by the book and its promise of being able to turn even a six-year-old into a competent combatant through well-structured human-computer interaction (Mead). However, it would appear that the novel’s moral regarding the psychological impact of actual screen-mediated combat did not dissuade military investment in drone warfare. The Air Force began using drones for surveillance during the Gulf War, but during the Global War on Terror they began to be equipped with weapons. By 2010, the US military operated over 7,000 drones, including over 200 weapons-ready Predator and Reaper drones. It now invests upwards of three-billion dollars a year into the drone program (Zucchino). While there are significant differences between contemporary drone warfare and the plot of Ender's Game—including the fact that Ender is a child, that he alone commands a fleet, that he thinks he is playing a game, and that, except for a single weapon of mass destruction, he and his enemies are equally well equipped—for this analysis, I will focus on their most important similarities: both Ender and actual drone operators work on teams for long shifts using video game-like technology to remotely control vehicles in aerial combat against an enemy. After he uses the Little Doctor, Mazer and Graff, Ender's long-time training supervisors, first work to circumvent his guilt by reframing his actions as heroic. “You're a hero, Ender. They've seen what you did, you and the others. I don't think there's a government on Earth that hasn't voted you their highest metal.” “I killed them all, didn't I?” Ender asked. “All who?” asked Graff. “The buggers? That was the idea.” Mazer leaned in close. “That's what the war was for.” “All their queens. So I killed all their children, all of everything.” “They decided that when they attacked us. It wasn't your fault. It's what had to happen.” Ender grabbed Mazer's uniform and hung onto it, pulling him down so they were face to face. “I didn't want to kill them all. I didn't want to kill anybody! I'm not a killer! […] but you made me do it, you tricked me into it!” He was crying. He was out of control. (Card 297–8)The novel up to this point has led us to believe that Ender at the very least understands that what he does in the game will be asked of him in real life. But his traumatic response to learning the truth reveals that he was in the magic circle. When he thinks he is playing a game, succeeding is a matter of ego: he wants to be the best, to live up to the expectations of his trainers that he is humanity’s last hope. When the magic circle is broken, Ender reconsiders his decision to use the Little Doctor. Tactics he could justify to win the game, reframed as real military tactics, threaten his sense of himself as a moral agent. Being told he is a hero provides no solace.Card wrote the novel during the Cold War, when computers were coming to play an increasingly large role in military operations. Historians of military technology have shown that during this time human behavior began to be defined in machine-like, functionalist terms by scientists working on cybernetic systems (see Edwards; Galison; Orr). Human skills were defined as components of large technological systems, such as tanks and anti-aircraft weaponry: a human skill was treated as functionally the same as a machine one. The only issue of importance was how all the components could work together in order to meet strategic goals—a cybernetic problem. The reasons that Mazer and Graff have for lying to Ender suggest that the author believed that as a form of technical augmentation, screen-mediation can be used to evacuate individual moral agency and submit human will to the command of the larger cybernetic system. Issues of displaced agency in the military cyborg assemblage are apparent in the following quote, in which Mazer compares Ender himself to the bomb he used to destroy the bugger home world: “You had to be a weapon, Ender. Like a gun, like the Little Doctor, functioning perfectly but not knowing what you were aimed at. We aimed you. We're responsible. If there was something wrong, we did it” (298). Questions of distributed agency have also surfaced in the drone debates. Government and military leaders have attempted to depersonalize drone warfare by assuring the American public that the list of targets is meticulously researched: drones kill those who we need killed. Drone warfare, media theorist Peter Asaro argues, has “created new and complex forms of human-machine subjectivity” that cannot be understood by considering the agency of the technology alone because it is distributed between humans and machines (25). While our leaders’s decisions about who to kill are central to this new cyborg subjectivity, the operators who fire the weapons nevertheless experience at least a retrospective sense of agency. As phenomenologist John Protevi notes, in the wake of wars fought by modern military networks, many veterans diagnosed with PTS still express guilt and personal responsibility for the outcomes of their participation in killing (Protevi). Mazer and Graff explain that the two qualities that make Ender such a good weapon also create an imperative to lie to him: his compassion and his innocence. For his trainers, compassion means a capacity to truly think like others, friend or foe, and understand their motivations. Graff explains that while his trainers recognized Ender's compassion as an invaluable tool, they also recognized that it would preclude his willingness to kill.It had to be a trick or you couldn't have done it. It's the bind we were in. We had to have a commander with so much empathy that he would think like the buggers, understand them and anticipate them. So much compassion that he could win the love of his underlings and work with them like a perfect machine, as perfect as the buggers. But somebody with that much compassion could never be the killer we needed. Could never go into battle willing to win at all costs. If you knew, you couldn't do it. If you were the kind of person who would do it even if you knew, you could never have understood the buggers well enough. (298)In learning that the game was real, Ender learns that he was not merely coming to understand a programmed simulation of bugger behavior, but their actual psychology. Therefore, his compassion has not only helped him understand the buggers’ military strategy, but also to identify with them.Like Ender, drone operators spend weeks or months following their targets, getting to know them and their routines from a God’s eye perspective. They both also watch the repercussions of their missions on screen. Unlike fighter pilots who drop bombs and fly away, drone operators use high-resolution cameras and fly much closer to the ground both when flying and assessing the results of their strikes. As one drone operator interviewed by the Los Angeles Times explained, "When I flew the B-52, it was at 30,000 to 40,000 feet, and you don't even see the bombs falling … Here, you're a lot closer to the actual fight, or that's the way it seems" (Zucchino). Brookings Institute scholar Peter Singer has argued that in this way screen mediation actually enables a more intimate experience of violence for drone operators than airplane pilots (Singer).The second reason Ender’s trainers give for lying is that they need someone not only compassionate, but also innocent of the horrors of war. The war veteran Mazer explains: “And it had to be a child, Ender,” said Mazer. “You were faster than me. Better than me. I was too old and cautious. Any decent person who knows what warfare is can never go into battle with a whole heart. But you didn't know. We made sure you didn't know" (298). When Ender discovers what he has done, he loses not only his innocence but his sense of himself as a moral agent. After such a trauma, his heart is no longer whole.Actual drone operators are, of course, not kept in a magic circle, innocent of the repercussions of their actions. Nor do they otherwise feel as though they are playing, as several have publicly stated. Instead, they report finding drone work tedious, and some even play video games for fun (Asaro). However, Air Force recruitment advertising makes clear analogies between the skills they desire and those of video game play (Brown). Though the first generations of drone operators were pulled from the ranks of flight pilots, in 2009 the Air Force began training them from the ground. Many drone operators, then, enter the role having no other military service and may come into it believing, on some level, that their work will be play.Recent military studies of drone operators have raised doubts about whether drone operators really experience high rates of trauma, suggesting that the stresses they experience are seated instead in occupational issues like long shifts (Ouma, Chappelle, and Salinas; Chappelle, Psy, and Salinas). But several critics of these studies have pointed out that there is a taboo against speaking about feelings of regret and trauma in the military in general and among drone operators in particular. A PTS diagnosis can end a military career; given the Air Force’s career-focused recruiting emphasis, it makes sense that few would come forward (Dao). Therefore, it is still important to take drone operator PTS seriously and try to understand how screen-mediation augments their experience of killing.While critics worry that warfare mediated by a screen and joystick leads to a “‘Playstation’ mentality towards killing” (Alston 25), Ender's Game presents a theory of remote-control war wherein this technological redistribution of the act of killing does not, in itself, create emotional distance or evacuate the killer’s sense of moral agency. In order to kill, Ender must be distanced from reality as well. While drone operators do not work shielded by the magic circle—and therefore do not experience the trauma of its dissolution—every day when they leave the cyborg assemblage of their work stations and rejoin their families they still have to confront themselves as individual moral agents and bear their responsibility for ending lives. In both these scenarios, a human agent’s combat trauma serves to remind us that even when their bodies are physically safe, war is hell for those who fight. This paper has illustrated how a science fiction story can be used as an analytic lens for thinking through contemporary discourses about human-technology relationships. However, the US military is currently investing in drones that are increasingly autonomous from human operators. This redistribution of agency may reduce incidence of PTS among operators by decreasing their role in, and therefore sense of moral responsibility for, killing (Axe). Reducing mental illness may seem to be a worthwhile goal, but in a world wherein militaries distribute the agency for killing to machines in order to reduce the burden on humans, societies will have to confront the fact that combatants’s trauma cannot be a compass by which to measure the morality of wars. Too often in the US media, the primary stories that Americans are told about the violence of their country’s wars are those of their own combatants—not only about their deaths and physical injuries, but their suicide and PTS. To understand war in such a world, we will need new, post-humanist stories where the cyborg assemblage and not the individual is held accountable for killing and morality is measured in lives taken, not rates of mental illness. ReferencesAlston, Phillip. “Report of the Special Rapporteur on Extrajudicial, Summary, or Arbitrary Executions, Addendum: Study on Targeted Killings.” United Nations Human Rights Council (2010). Asaro, Peter M. “The Labor of Surveillance and Bureaucratized Killing: New Subjectivities of Military Drone Operators”. Social Semiotics 23.2 (2013): 196-22. Associated Press. “Predator Pilots Suffering War Stress.” Military.com 2008. Axe, David. “How to Prevent Drone Pilot PTSD: Blame the ’Bot.” Wired June 2012.Bowden, Mark. “The Killing Machines: How to Think about Drones.” The Atlantic Sep. 2013.Brown, Melissa T. Enlisting Masculinity: The Construction of Gender in US Military Recruiting Advertising during the All-Volunteer Force. London: Oxford University Press, 2012. Bumiller, Elisabeth. “Air Force Drone Operators Report High Levels of Stress.” New York Times 18 Dec. 2011: n. pag. Card, Orson Scott. Ender’s Game. Tom Doherty Associates, Inc., 1985. Chappelle, Wayne, D. Psy, and Amber Salinas. “Psychological Health Screening of Remotely Piloted Aircraft (RPA) Operators and Supporting Units.” Paper presented at the Symposium on Mental Health and Well-Being across the Military Spectrum, Bergen, Norway, 12 April 2011: 1–12. Dao, James. “Drone Pilots Are Found to Get Stress Disorders Much as Those in Combat Do.” New York Times 22 Feb. 2013: n. pag. Edwards, Paul N. The Closed World: Computers and the Politics of Discourse in Cold War America. Cambridge: MIT Press, 1997.Galison, Peter. “The Ontology of the Enemy: Norbert Wiener and the Cybernetic Vision.” Critical Inquiry 21.1 (1994): 228.Gray, Chris Hables “Posthuman Soldiers in Postmodern War.” Body & Society 9.4 (2003): 215–226. 27 Nov. 2010.Greene, David, and Kelly McEvers. “Former Air Force Pilot Has Cautionary Tales about Drones.” National Public Radio 10 May 2013.Grossman, David. On Killing. Revised. Boston: Back Bay Books, 2009. Harmon, Amy. “More than Just a Game, But How Close to Reality?” New York Times 3 Apr. 2003: n. pag. Levidow, Les, and Robins. Cyborg Worlds: The Military Information Society. London: Free Association Books, 1989. Lifton, Robert Jay. Home from the War: Vietnam Veterans: Neither Victims nor Executioners. New York: Random House, 1973. Mead, Corey. War Play: Video Games and the Future of Armed Conflict. Boston: Houghton Mifflin Harcourt, 2013. Orr, Jackie. Panic Diaries: A Genealogy of Panic Disorder. Durham: Duke University Press, 2006.Ouma, J.A., W.L. Chappelle, and A. Salinas. Facets of Occupational Burnout among US Air Force Active Duty and National Guard/Reserve MQ-1 Predator and MQ-9 Reaper Operators. Air Force Research Labs Technical Report AFRL-SA-WP-TR-2011-0003. Wright-Patterson AFB, OH: Air Force Research Laboratory. 2011.Protevi, John. “Affect, Agency and Responsibility: The Act of Killing in the Age of Cyborgs.” Phenomenology and the Cognitive Sciences 7.3 (2008): 405–413. Salen, Katie, and Eric Zimmerman. Rules of Play: Game Design Fundamentals. Cambridge, MA: MIT Press, 2003. Saleton, William. “Ghosts in the Machine: Do Remote-Control War Pilots Get Combat Stress?” Slate.com Aug. 2008. Schachtman, Nathan. “Shrinks Help Drone Pilots Cope with Robo-Violence.” Wired Aug. 2008.Silberman, Steve. “The War Room.” Wired Sep. 2004: 1–5.Singer, P.W. Wired for War: The Robotics Revolution and Conflict in the Twenty-First Century. New York: Penguin Press, 2009. Zucchino, David. “Drone Pilots Have Front-Row Seat on War, from Half a World Away.” Los Angeles Times 21 Feb. 2010: n. pag.

The Creative City Unlike the terms ‘creative industries’, which nobody ever quite understood, and ‘creative class’, about which actual ‘creatives’ were always ambiguous, the ‘creative city’ has been an incredibly successful global policy meme, to which cities across the world continue to aspire. From the early 1990s, faced with de-industrialisation, rising unemployment, and the increased global mobility of capital, professionals, and consumer-tourists, the ‘creative city’ became an essential part of the new urban imaginary for politicians, planners, local growth coalitions, and advocates and practitioners in art and culture. In the later 1980s and early 1990s, much of this policy and practice work had progressive intent; as decaying parts of the city acquired new artistic and cultural uses, and neo-bohemian lifestyles and pop-cultural aspirations seemed to provide the grounds for future-oriented urban identities. Whilst investment in iconic cultural buildings and refurbished heritage sites repositioned cities as destinations for global tourism and finance (Peck et al.), new forms of creative production would provide employment and catalyse the wider urban economy. The creative city was to be a benign economy of innovative small businesses, working in projects and acting in symbiosis with the transformed urban landscape of the city (Pratt; Scott). If at first such a “creativity fix” (Peck, Creativity) was permeable to new actors and radical visions, it rapidly became a codified “cookie cutter” approach (Oakley), primarily concerned with revalorising decaying urban built stock as ‘vibrant’ spaces for upmarket urban consumption. This has stretched from visual arts to popular music (Bennett; O’Connor Music). The “creative imaginary” of entrepreneurial subjects—working in flat networks clustered around zones or milieux of intensified creativity (O’Connor and Shaw; O’Connor and Gu)—was quickly localised in spaces of real estate-led consumption, with production corralled into the ‘managed workspace’ whose image value—a shiny ‘creative hub’—was usually worth far more than any actual production taking place inside of it (O’Connor, Art). From the turn of the millennium, this global “fast policy” flowed through elite circuits of ‘policy transfer’ (Peck, Scale): unevenly distributed nodes assembling politicians, public administrators, planners, ‘cool’ developers, cultural consultants, branded arts institutions, and creative ‘thought-leaders’ (De Beukelaer and O’Connor). Global agencies such as UNESCO, through its Creative Cities Network, or consultancies such as Charles Landry and BOP, have attempted to frame this in a benign narrative of ‘hands across the ocean’ cultural globalisation. But we now know from two decades of creative economy proselytising that culture is a “driver and enabler” of development, not a normative standard against which it might be judged. And however inclusive ‘culture’ is made to sound, the creative city agenda remains firmly in the hands of local elites attempting to harness global flows of finance, media images, tourists, and ‘creatives’ for local development opportunities (Novy and Colomb; Courage and McKeown). By 2008 the creative city was already in trouble, as an increasingly brutal wave of gentrification came to be seen as the necessary corollary of the gleaming images of creative clusters, hipster hangouts, and iconic arts infrastructure. Predicated on a “spatial fix” (Harvey) for the decaying landscapes of the industrial city, the creative city was already producing its own ruins, as culture-led investment projects failed (Brodie). Since 2008, as the paper-thin walls between art, creativity, and real estate capital dissolved, it became increasingly clear that, though the script remained, the utopian moment was dead and buried. For many critics, both inside the cultural sector and out, it was time to roughly bundle it into the catch-all of neoliberalism and ‘gentrification’ and throw it overboard. Creative City RIP. The Ordinary City This critical take was performed early on by geographers such as Ash Amin and others (Amin and Graham; Amin, Massey, and Thrift), who suggested we re-centre the ordinary city—the one in which most people live—rather than fetishise some high-growth, hi-tech, gleaming Creative City. It was reiterated more recently by the Foundational Economy Collective, who argue that it is the everyday infrastructures and services of our towns and cities—and their mundane local economies of nail bars, cafes, and auto-repair shops—that should form the basis of our urban economic thinking (FEC). Jamie Peck, an early critic of the Creative City, had already cast doubt on the real economic weight of ‘creative industries’ and saw the whole thing as cover for the ‘entrepreneurial (read: neoliberal) city’, and a new kind of culturally-inflected growth coalition (Peck and Ward; Peck, Struggling). Similar dissent could be found amongst those writing within the cultural field. For every new city on the global creative smorgasbord, there were local artists and community activists who could show you a whole other side, excluded from the glass boxes and white cubes, from the funding and the hyped-up narratives lavished on the creative city. This mostly targeted the big iconic developments, led by global brands sucking the funding and the imagination from the surrounding city—what we might call ‘the Bilbao effect’. This cynicism toward the Creative City overlapped with a rejection of a ‘high art’ establishment and its elitist forms of culture. The ‘ordinary city’ here did not set the mundane against art and culture but reframed these as part of an everyday creativity. This could mean small-scale, neighbourhood-embedded art and culture, proposed by those in favour of ‘community arts’ and indeed those seeking localised popular culture such as music scenes. But it could also mean a valorisation of creativity writ large; a generalised urban creativity in which imagination and experimentation, but also subversion and contestation permeate the everyday. Following the Global Financial Crisis (GFC), critiques of the creative city concept became increasingly common. Oli Mould’s 2015 book Urban Subversion and the Creative City captures much of this, providing a distinction between the capitalised Creative City and the lower-case creative city. Mould distinguishes between the ‘Creative City’ ideology as extractive, and the ‘creative city’ as enabling citizenship. For Mould, the Creative City is “the antithesis of urban creativity” (Urban 4), and “shorthand for the capitalistic, paradigmatic (bordering on dogmatic) and meta-narrative view of how creativity can be used to economically stimulate and develop the city” (5). It is top-down creative planning at its worst. Against this, Mould evokes the lower-case concept of creative city, seeing some hope for it as a descriptor of urban spaces where “being creative is the very act of citizenship” (5). The Creative City imposed itself as a requirement of urban economic competitiveness (successful or not) and needs to be implacably opposed. Alternatively, the creative city persists in various forms of ‘urban subversion’, though whether the actual term—like creativity itself (Mould, Against)—can be freed from an association with its capitalised nemesis is, for Mould, still moot. Whilst Mould’s distinction allows us to evoke an urban creativity distinct from the commodified, extractive forms of the Creative City—one rooted in the ordinary, everyday creative practices of the city still open to themes of subversion and contestation centring cultural labour over cultural infrastructure—we also have some reservations. The C/creative couplet recalls de Certeau’s opposition of strategy and tactics, skyscraper and street, and has some of its problems. Baldly, this gives control of the city over to the powerful and condemns the rest of us to a game of endless evasion and subversion. For whilst the contemporary Creative City agenda may be largely as Mould describes it, its provenance is more complex than the extractive agenda which currently animates it. Understanding this provenance might give us some pointers beyond this binary impasse. Roots of the Creative City Although the Creative City eventually became integrated into the neoliberal urban script, the policy imaginary that birthed it emerged from the post-1960s rise of urban social movements, anti-development coalitions, new cultural practices (especially around popular music), artist co-ops, squats, and alternative cultures. Across the 1970s and 1980s one might say the C/creative City was an aspect of growing claims for cultural citizenship, the more explicit acknowledgement of a cultural dimension within T.H. Marshall’s ‘social citizenship’ (Marshall). The Greater London Council (GLC) of 1979-86 is exemplary here (Bianchini; Hatherley), but this was only the most visible case in which de-industrialising cities acquired aspirations to a different kind of city living. The utopian-romantic vision of a new kind of urban culture in which the transformative powers of art would abandon the ethereal world of the museum-gallery and take carnal form in the grotesque ruins of an industrial city was most literal in Wim Wenders’s 1987 film Wings of Desire. It was there in Berlin and New York as it was in Melbourne and Manchester, and a hundred other such cities (Whitney). As an industrial urban civilisation no longer seemed viable in the Global North, ‘culture’ became a central stake in anticipating what might come next. What new forms of working and living might be possible? What new identities, pleasures, desires might it accommodate? A new generation, immersed in what Mark Fisher called ‘popular modernism’ (Fisher), sought new forms of artistic expression within popular culture, making demands on the formal cultural system, on the infrastructure of the city, and on how the city could be re-imagined. In short, the C/creative City was not simply an invention of neoliberalism. It carried within it a utopian promise that should not be discounted. Perhaps we can see this in that most vilified of concepts, the ‘creative class’. The (Not-So) Creative Class By the 2008 GFC, the concept of the ‘creative class’—positioned as the primary driver and beneficiary of the creative city—was already coming apart. Unaffordable housing, rent hikes, rising debts, welfare cuts, reducing returns to ‘educational capital’ and the dominance of asset economies, precarious employment, culture budget cuts, and the integration of large sections of creative production into new platform economies have accelerated since that time. Global development capital has now built high-end leisure, entertainment, accommodation, and amenities into its core business model, one that does not require a prior process of valorisation by local creatives. Mould suggests the Creative City was a Trojan Horse and the creative class the Greeks inside (Urban 8). But whilst policymakers and city marketers embraced this term, it was never a class for-itself, with the clear strategic focus of soldiers waiting to pounce. Florida’s statistical fantasy netted a massive chunk of the population—almost 40 percent—as ‘professional, managerial and scientific’ (Florida, Rise). Meanwhile actual ‘creatives’ were always a poor relation and lived very differently to those others, most of whom preferred the suburbs and ex-burbs to the bustling city. Artists were not the storm-troopers of gentrification but its dupes, eventually evicted from the city they helped conquer. Meanwhile, since the advent of Florida and Landry, developers didn’t even need to use these ‘storm-troopers’ to soften up places for gentrification. They could now work directly with compliant city authorities to do the work for them. Creative cities could be deployed by toolkit (Landry) and, of course, measured via economic impact studies and a variety of other econometrics weaponised by corporate consultancies for hire. This was the social and political landscape upon which the Global Financial Crisis dealt an especially severe form of austerity, disproportionately affecting the cultural sector, and exacerbating many of the problematic areas of ‘creative city’ policy that had previously been abated and ameliorated by a veneer of hipster cool. Nonetheless, the ‘creative class’ also articulated a utopian promise, especially in places outside of the ‘Global North’ where more traditional forms of political power, gender roles, and religion remain in play. In a period of rapid globalisation, as relatively insulated economies became integrated into global capital flows, and cities bore the brunt of disruptive social and cultural changes, the C/creative City could stand in for a global modernity with a future. It could make available a new set of aspirations and identities; for a younger, more educated few perhaps, yet still real despite this. De Beukelaer, in the Indonesian context, talks about the “productive friction” between the two C/creative Cities, where the gap between the universal abstract and the local reality can form a site of negotiation. The C/creative City licences an encounter between new aspirations and identities, and the more traditional elites; an unequal struggle to define or give further content to the neoliberal nostrums of creative modernity that emanate from the Creative City meme. Yet it is not clear just why this negotiation is only made possible by the ‘apolitical’ notion of ‘creative’, or what’s at stake in that term. Is it a merely a cypher—or McGuffin—for a more complex conflict of interests? In what form would the “re-politicisation” of the creative city, called for at the end of the article, consist? What Next? We are not then talking about The City & the City (Mieville), in which two cities occupy the same geographic space but codify their separation by routinely ignoring each other and that which is deemed to belong to the other city. They are always in some kind of negotiation and contestation, but around what? We would argue that the imaginary of the C/creative City was annexed by, but not necessarily created by, neoliberalism. If the C/creative City articulated a future beyond a Fordist industrial civilisation, then we must take care in rejecting it not to abandon at the same time the power to imagine a different future. So, too, in attempting to assert the ordinary everyday city, we must also keep hold of a sense of the creative imagination that art and culture articulates, rather than dismissing this as part of the shiny glass palace on the hill. The absence of art and culture from the new progressive social and economic agendas that are currently finding their way into the mainstream—green new deals, doughnuts, well-being, community and ecological economics, and so on—is telling (O’Connor, Reset). In part this reflects the capture of arts and cultural policy by neoliberalism. This is not just ‘economic rationalism’ or market fundamentalism, for in the ‘creative economy’ art and cultural policy fused with neoliberalism at a deep DNA level, and the creative city imaginary was part of this. Mould is right to doubt whether the notion of ‘creative’, so closely enmeshed, could ever be retrieved. But regardless of whether art and culture have been condemned by this close association, the collapse of its romantic-utopian promise into a consumer leisure economy has left a void. If Jameson’s contention that we cannot think the end of capitalism is no longer the case (Jameson; Morozov), then culture is not present at this new moment of transition. So much well-being, community, and ecological economics speaks of culture whilst barely naming it. For us, the rearticulation of the place of art and culture in the contemporary city is crucial. We would even suggest that without art and culture, a full transformation of the contemporary city would be impossible. But how to think this? Any democratic cultural policy would need to reclaim both the ordinary and the creative city. This would entail the creative city of dissent and subversion, so closely aligned with the broad social movements to which we must look, in large part, to transform the city. It would also mean the right to a full participation in the imaginary of the collective city in which we all dwell and where we can imagine different futures. For this to happen, art and culture needs to be taken out of the hands of real estate, tourism, and economic development, and reframed as part of public service and public value. Just as new movements seek to reframe economic growth in terms of sustainability, equity, and human flourishing (Raworth), a radical creative city would be one in which art and culture were constitutive of the social foundations and part of how we live together as citizens, not simply another engine of the consumption economy. This process of re-embedding art and culture in the everyday foundations of the ordinary city is certainly underway. The ‘new municipalism’ (Thompson) has begun to make space for culture, with cities such as Barcelona and organisations such as the UCLG making a lot of the running. Notions of cultural rights, both individual and collective, have returned to challenge the urban consumption model. Just as art and culture try to position themselves alongside other foundational services—health, education, welfare—they also need to engage with new approaches to urban design, where technologies and infrastructures have been repositioned as cultural rather than technological. This suggests both that art and culture engage with the wider ‘cultural’—as in the anthropological, ‘whole way of life’—but that it no longer ‘owns’ this culture. Art and culture are not to be seen, as in the 1980s, as the ‘key’ to a total social transformation, but as one element only, however crucial. So too ‘creative’ needs to be unpicked and reframed, away from its association with ‘progress’ and absolute self-creation towards ‘slowdown’ (Dorling), sustainability, custodianship, care, incrementalism, and restoration – the kinds of values we now associate with First Nations. The shared DNA between creativity and capitalist modernity runs deep. Conclusion The COVID-19 pandemic has devastated large areas of art and culture, putting a question mark next to the urban use patterns that underpinned so much of the creative city model (Banks and O’Connor; de Peuter et al.; Tanghetti et al.; Whiting and Roberts). The Creative City of consumption, commuting, tourism, and entertainment stopped. Though some construction continued, the very purpose of the city centre—which over three decades had been rebranded as the Central Business District—was called into question. But the creative city was devastated too. Not just the collapse in income for cultural workers and business owners, but so too the filigrees of creative connection, the rhizomic mica that underpin the ecosystem of the city. Creatives already made no money, but at least they could go to openings and stay out late. Not anymore. This knockout blow was followed by the recognition that, for all the creative rhetoric, it was construction spending that counted most towards cultural funding budgets (Pacella et al.). Whilst talk quickly became one of getting artists and creatives to kickstart urban activity and animate deserted main street properties—‘build back better’—it is not at all clear where this endless supply of artists is going to come from. Now might be the time to explore how we might rethink art, culture, and the city rather than business as usual. As Arundhati Roy suggested, “nothing could be worse than a return to normality. Historically, pandemics have forced humans to break with the past and imagine their world anew. This one is no different. It is a portal, a gateway between one world and the next” (Roy). If art and culture don’t form part of that search for the new world, they will end up simply defending this one. 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In the 2019 documentary Chasing Happiness, recording artist/musician Joe Jonas tells audiences that the band was “living the dream”. Similarly, in the 2012 documentary Artifact, lead singer Jared Leto remarks that at the height of Thirty Seconds to Mars’s success, they “were living the dream”. However, for both the Jonas Brothers and Thirty Seconds to Mars, their experiences of the music industry (much like other commercially successful recording artists) soon transformed into nightmares. Similar to other commercially successful recording artists, the Jonas Brothers and Thirty Seconds to Mars, came up against the constraints of the industry which inevitably led to a forfeiting of authenticity, a loss of creative control, increased exploitation, and unequal remuneration. This work will consider how working in the music industry is not always a dream come true and can instead be viewed as a proverbial nightmare. Living the DreamIn his book Dreams, Carl Gustav Jung discusses how that which is experienced in sleep, speaks of a person’s wishes: that which might be desired in reality but may not actually happen. In his earlier work, The Interpretation of Dreams, Freud argued that the dream is representative of fulfilling a repressed wish. However, the creative industries suggest that a dream need not be a repressed wish; it can become a reality. Jon Bon Jovi believes that his success in the music industry has surpassed his wildest dreams (Atkinson). Jennifer Lopez considers the fact that she held big dreams, had a focussed passion, and strong aspirations the reason why she pursued a creative career that took her out of the Bronx (Thomas). In a Twitter post from 23 April 2018, Bruno Mars declared that he “use [sic] to dream of this shit,” in referring to a picture of him performing for a sold out arena, while in 2019 Shawn Mendes informed his 24.4 million Twitter followers that his “life is a dream”. These are but a few examples of successful music industry artists who are seeing their ‘wishes’ come true and living the American Dream.Endemic to the American culture (and a characteristic of the identity of the country) is the “American Dream”. It centres on “a land in which life should be better and richer and fuller for every man, with opportunity for each according to his ability and achievement” (Adams, 404). Although initially used to describe having a nice house, money, stability and a reasonable standard of living, the American Dream has since evolved to what the scholar Florida believes is the new ‘aspiration of people’: doing work that is enjoyable and relies on human creativity. At its core, the original American Dream required striving to meet individual goals, and was promoted as possible for anyone regardless of their cultural, socio-economic and political background (Samuel), because it encourages the celebrating of the self and personal uniqueness (Gamson). Florida’s conceptualisation of the New American dream, however, tends to emphasise obtaining success, fame and fortune in what Neff, Wissinger, and Zukin (310) consider “hot”, “creative” industries where “the jobs are cool”.Whether old or new, the American Dream has perpetuated and reinforced celebrity culture, with many of the young generation reporting that fame and fortune were their priorities, as they sought to emulate the success of their famous role models (Florida). The rag to riches stories of iconic recording artists can inevitably glorify and make appealing the struggle that permits achieving one’s dream, with celebrities offering young, aspiring creative people a means of identification for helping them to aspire to meet their dreams (Florida; Samuel). For example, a young Demi Lovato spoke of how she idolised and looked up to singer Beyonce Knowles, describing Knowles as a role model because of the way she carries herself (Tishgart). Similarly, American Idol winner Kelly Clarkson cited Aretha Franklin as her musical inspiration and the reason that she sings from a place deep within (Nilles). It is unsurprising then, that popular media has tended to portray artists working in the creative industries and being paid to follow their passions as “a much-vaunted career dream” (Duffy and Wissinger, 4656). Movies such as A Star Is Born (2018), The Coal Miner’s Daughter (1980), Dreamgirls (2006), Begin Again (2013) and La La Land (2016) exalt the perception that creativity, talent, sacrifice and determination will mean dreams come true (Nicolaou). In concert with the American dream is the drive among creative people pursuing creative success to achieve their dreams because of the perceived autonomy they will gain, the chance of self-actualisation and social rewards, and the opportunity to fulfil intrinsic motivations (Amabile; Auger and Woodman; Cohen). For these workers, the love of creation and the happiness that accompanies new discoveries (Csikszentmihalyi) can offset the tight budgets and timelines, precarious labour (Blair, Grey, and Randle; Hesmondhalgh and Baker), uncertain demand (Caves; Shultz), sacrifice of personal relationships (Eikhof and Haunschild), the demand for high quality products (Gil & Spiller), and the tense relationships with administrators (Bilton) which are known to plague these industries. In some cases, young, up and coming creative people overlook these pitfalls, instead romanticising creative careers as ideal and worthwhile. They willingly take on roles and cede control to big corporations to “realize their passions [and] uncover their personal talent” (Bill, 50). Of course, as Ursell argues in discussing television employees, such idealisation can mean creatives, especially those who are young and unfamiliar with the constraints of the industry, end up immersed in and victims of the “vampiric” industry that exploits workers (816). They are socialised towards believing, in this case, that the record label is a necessary component to obtain fame and fortune and whether willing or unwilling, creative workers become complicit in their own exploitation (Cohen). Loss of Control and No CompensationThe music industry itself has been considered by some to typify the cultural industries (Chambers). Popular music has potency in that it is perceived as speaking a universal language (Burnett), engaging the emotions and thoughts of listeners, and assisting in their identity construction (Burnett; Gardikiotis and Baltzis). Given the place of music within society, it is not surprising that in 2018, the global music industry was worth US$19.1billion (IFPI). The music industry is necessarily underpinned by a commercial agenda. At present, six major recording companies exist and between them, they own between 70-80 per cent of the recordings produced globally (Konsor). They also act as gatekeepers, setting trends by defining what and who is worth following and listening to (Csikszentmihalyi; Jones, Anand, and Alvarez). In essence, to be successful in the music industry is to be affiliated with a record label. This is because the highly competitive nature and cluttered environment makes it harder to gain traction in the market without worthwhile representation (Moiso and Rockman). In the 2012 documentary about Thirty Seconds to Mars, Artifact, front man Jared Leto even questions whether it is possible to have “success without a label”. The recording company, he determines, “deal with the crappy jobs”. In a financially uncertain industry that makes money from subjective or experience-based goods (Caves), having a label affords an artist access to “economic capital for production and promotion” that enables “wider recognition” of creative work (Scott, 239). With the support of a record label, creative entrepreneurs are given the chance to be promoted and distributed in the creative marketplace (Scott; Shultz). To have a record label, then, is to be perceived as legitimate and credible (Shultz).However, the commercial music industry is just that, commercial. Accordingly, the desire to make money can see the intrinsic desires of musicians forfeited in favour of standardised products and a lack of remuneration for artists (Negus). To see this standardisation in practice, one need not look further than those contestants appearing on shows such as American Idol or The Voice. Nowhere is the standardisation of the music industry more evident than in Holmes’s 2004 article on Pop Idol. Pop Idol first aired in Britain from 2001-2003 and paved the way for a slew of similar shows around the world such as Australia’s Popstars Live in 2004 and the global Idol phenomena. According to Holmes, audiences are divested of the illusion of talent and stardom when they witness the obvious manufacturing of musical talent. The contestants receive training, are dressed according to a prescribed image, and the show emphasises those melodramatic moments that are commercially enticing to audiences. Her sentiments suggest these shows emphasise the artifice of the music industry by undermining artistic authenticity in favour of generating celebrities. The standardisation is typified in the post Idol careers of Kelly Clarkson and Adam Lambert. Kelly Clarkson parted with the recording company RCA when her manager and producer Clive Davis told her that her album My December (2007) was “not commercial enough” and that Clarkson, who had written most of the songs, was a “shitty writer… who should just shut up and sing” (Nied). Adam Lambert left RCA because they wanted him to make a full length 80s album comprised of covers. Lambert commented that, “while there are lots of great songs from that decade, my heart is simply not in doing a covers album” (Lee). In these instances, winning the show and signing contracts led to both Clarkson and Lambert forfeiting a degree of creative control over their work in favour of formulaic songs that ultimately left both artists unsatisfied. The standardisation and lack of remuneration is notable when signing recording artists to 360° contracts. These 360° contracts have become commonplace in the music industry (Gulchardaz, Bach, and Penin) and see both the material and immaterial labour (such as personal identities) of recording artists become controlled by record labels (Stahl and Meier). These labels determine the aesthetics of the musicians as well as where and how frequently they tour. Furthermore, the labels become owners of any intellectual property generated by an artist during the tenure of the contract (Sanders; Stahl and Meier). For example, in their documentary Show Em What You’re Made Of (2015), the Backstreet Boys lament their affiliation with manager Lou Pearlman. Not only did Pearlman manufacture the group in a way that prevented creative exploration by the members (Sanders), but he withheld profits to the point that the Backstreet Boys had to sue Pearlman in order to gain access to money they deserved. In 2002 the members of the Backstreet Boys had stated that “it wasn’t our destinies that we had to worry about in the past, it was our souls” (Sanders, 541). They were not writing their own music, which came across in the documentary Show Em What You’re Made Of when singer Howie Dorough demanded that if they were to collaborate as a group again in 2013, that everything was to be produced, managed and created by the five group members. Such a demand speaks to creative individuals being tied to their work both personally and emotionally (Bain). The angst encountered by music artists also signals the identity dissonance and conflict felt when they are betraying their true or authentic creative selves (Ashforth and Mael; Ashforth and Humphrey). Performing and abiding by the rules and regulations of others led to frustration because the members felt they were “being passed off as something we aren’t” (Sanders 539). The Backstreet Boys were not the only musicians who were intensely controlled and not adequately compensated by Pearlman. In the documentary The Boy Band Con: The Lou Pearlman Story 2019, Lance Bass of N*Sync and recording artist Aaron Carter admitted that the experience of working with Pearlman became a nightmare when they too, were receiving cheques that were so small that Bass describes them as making his heart sink. For these groups, the dream of making music was undone by contracts that stifled creativity and paid a pittance.In a similar vein, Thirty Seconds to Mars sought to cut ties with their record label when they felt that they were not being adequately compensated for their work. In retaliation EMI issued Mars with a US$30 million lawsuit for breach of contract. The tense renegotiations that followed took a toll on the creative drive of the group. At one point in the documentary Artifact (2012), Leto claims “I can’t sing it right now… You couldn’t pay me all the money in the world to sing this song the way it needs to be sung right now. I’m not ready”. The contract subordination (Phillips; Stahl and Meier) that had led to the need to renegotiate financial terms came at not only a financial cost to the band, but also a physical and emotional one. The negativity impacted the development of the songs for the new album. To make music requires evoking necessary and appropriate emotions in the recording studio (Wood, Duffy, and Smith), so Leto being unable to deliver the song proved problematic. Essentially, the stress of the lawsuit and negotiations damaged the motivation of the band (Amabile; Elsbach and Hargadon; Hallowell) and interfered with their creative approach, which could have produced standardised and poor quality work (Farr and Ford). The dream of making music was almost lost because of the EMI lawsuit. Young creatives often lack bargaining power when entering into contracts with corporations, which can prove disadvantaging when it comes to retaining control over their lives (Phillips; Stahl and Meier). Singer Demi Lovato’s big break came in the 2008 Disney film Camp Rock. As her then manager Phil McIntyre states in the documentary Simply Complicated (2017), Camp Rock was “perceived as the vehicle to becoming a superstar … overnight she became a household name”. However, as “authentic and believable” as Lovato’s edginess appeared, the speed with which her success came took a toll on Lovato. The pressure she experienced having to tour, write songs that were approved by others, star in Disney channel shows and movies, and look a certain way, became too much and to compensate, Lovato engaged in regular drug use to feel free. Accordingly, she developed a hybrid identity to ensure that the squeaky clean image required by the moral clauses of her contract, was not tarnished by her out-of-control lifestyle. The nightmare came from becoming famous at a young age and not being able to handle the expectations that accompanied it, coupled with a stringent contract that exploited her creative talent. Lovato’s is not a unique story. Research has found that musicians are more inclined than those in other workforces to use psychotherapy and psychotropic drugs (Vaag, Bjørngaard, and Bjerkeset) and that fame and money can provide musicians more opportunities to take risks, including drug-use that leads to mortality (Bellis, Hughes, Sharples, Hennell, and Hardcastle). For Lovato, living the dream at a young age ultimately became overwhelming with drugs her only means of escape. AuthenticityThe challenges then for music artists is that the dream of pursuing music can come at the cost of a musician’s authentic self. According to Hughes, “to be authentic is to be in some sense real and true to something ... It is not simply an imitation, but it is sincere, real, true, and original expression of its creator, and is believable or credible representations or example of what it appears to be” (190). For Nick Jonas of the Jonas Brothers, being in the spotlight and abiding by the demands of Disney was “non-stop” and prevented his personal and musical growth (Chasing Happiness). As Kevin Jonas put it, Nick “wanted the Jonas Brothers to be no more”. The extensive promotion that accompanies success and fame, which is designed to drive celebrity culture and financial motivations (Currid-Halkett and Scott; King), can lead to cynical performances and dissatisfaction (Hughes) if the identity work of the creative creates a disjoin between their perceived self and aspirational self (Beech, Gilmore, Cochrane, and Greig). Promoting the band (and having to film a television show and movies he was not invested in all because of contractual obligations) impacted on Nick’s authentic self to the point that the Jonas Brothers made him feel deeply upset and anxious. For Nick, being stifled creatively led to feeling inauthentic, thereby resulting in the demise of the band as his only recourse.In her documentary Gaga: Five Foot Two (2017), Lady Gaga discusses the extent she had to go to maintain a sense of authenticity in response to producer control. As she puts it, “when producers wanted me to be sexy, I always put some absurd spin on it, that made me feel like I was still in control”. Her words reaffirm the perception amongst scholars (Currid-Halkett and Scott; King; Meyers) that in playing the information game, industry leaders will construct an artist’s persona in ways that are most beneficial for, in this case, the record label. That will mean, for example, establishing a coherent life story for musicians that endears them to audiences and engaging recording artists in co-branding opportunities to raise their profile and to legitimise them in the marketplace. Such behaviour can potentially influence the preferences and purchases of audiences and fans, can create favourability, originality and clarity around artists (Loroz and Braig), and can establish competitive advantage that leads to producers being able to charge higher prices for the artists’ work (Hernando and Campo). But what impact does that have on the musician? Lady Gaga could not continue living someone else’s dream. She found herself needing to make changes in order to avoid quitting music altogether. As Gaga told a class of university students at the Emotion Revolution Summit hosted by Yale University:I don’t like being used to make people money. It feels sad when I am overworked and that I have just become a money-making machine and that my passion and creativity take a backseat. That makes me unhappy.According to Eikof and Haunschild, economic necessity can threaten creative motivation. Gaga’s reaction to the commercial demands of the music industry signal an identity conflict because her desire to create, clashed with the need to be commercial, with the outcome imposing “inconsistent demands upon” her (Ashforth and Mael, 29). Therefore, to reduce what could be considered feelings of dissonance and inconsistency (Ashforth and Mael; Ashforth and Humphrey) Gaga started saying “no” to prevent further loss of her identity and sense of authentic self. Taking back control could be seen as a means of reorienting her dream and overcoming what had become dissatisfaction with the commercial processes of the music industry. ConclusionsFor many creatives working in the creative industries – and specifically the music industry – is constructed as a dream come true; the working conditions and expectations experienced by recording artists are far from liberating and instead can become nightmares to which they want to escape. The case studies above, although likely ‘constructed’ retellings of the unfortunate circumstances encountered working in the music industry, nevertheless offer an inside account that contradicts the prevailing ideology that pursuing creative passions leads to a dream career (Florida; Samuel). If anything, the case studies explored above involving 30 Seconds to Mars, the Jonas Brothers, Lady Gaga, Kelly Clarkson, Adam Lambert and the Backstreet Boys, acknowledge what many scholars writing in the creative industries have already identified; that exploitation, subordination, identity conflict and loss of control are the unspoken or lesser known consequences of pursuing the creative dream. That said, the conundrum for creatives is that for success in the industry big “creative” businesses, such as recording labels, are still considered necessary in order to break into the market and to have prolonged success. This is simply because their resources far exceed those at the disposal of independent and up-and-coming creative entrepreneurs. Therefore, it can be argued that this friction of need between creative industry business versus artists will be on-going leading to more of these ‘dream to nightmare’ stories. The struggle will continue manifesting in the relationship between business and artist for long as the recording artists fight for greater equality, independence of creativity and respect for their work, image and identities. 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[estratto dall'intoduzione] In un percorso che si snoda parallelamente alla biografia dell’artista viene restituita la mappatura della geografia artistica di Loth, attraverso la ricostruzione della trama dei rapporti che accompagnarono le principali commissioni soddisfatte dall’artista e che connotarono i contesti di ricezione figurativa, collezionistica e storiografica delle sue opere. Sono state tracciate, pertanto, le interconnessioni fra le scelte linguistiche o stilistiche e di genere adottate da Loth nel corso della sua carriera e i diversi contesti culturali di ricezione delle medesime (Venezia e l’entroterra veneto, l’Impero austriaco, i territori germanici e Firenze). La risistemazione e la rivalutazione delle conoscenze oggettive della vicende dell’artista e delle sue opere, debitrici del minuzioso lavoro di catalogazione condotto da Ewald, nonché delle sue scoperte documentarie – le più rilevanti ancora sull’artista –, e che sono state puntigliosamente collazionate con i più recenti aggiornamenti (Fusari 2017), è stata condotta parallelamente a una disamina attenta delle principali fonti storiografiche e critiche tradizionali (Boschini e Sandrart, in primis), della letteratura periegetica, della corrispondenza fra mecenati, artisti e collezionisti, degli inventari delle raccolte o dei cataloghi a stampa e delle descrizioni letterarie. Si è provveduto, inoltre, a revisionare il materiale archivistico e documentario già pubblicato, accanto allo spoglio di ulteriori e inesplorati fondi. Una fase importante della ricerca è stata quindi dedicata ai sopralluoghi condotti presso svariate istituzioni museali o ecclesiastiche, utili sia per verificare l’attuale reperibilità del materiale menzionato nelle fonti, sia per approfondire gli aspetti della provenienza, della musealizzazione e della storia conservativa dei dipinti di Loth. [...]

Abstract It has three brands in play, but only flagship Volkswagen (VW) has captured significant space in mind and market. Now, the German auto group is looking to unleash the collective power of Skoda, VW, and Audi in India with the prospect of more brands being launched. Lutz Kothe first stepped on Indian soil in 2008 to attend the Auto Expo in New Delhi. At 4 am the head of marketing at VW India strode into the Park Hotel and, when checking in, said he was from Volkswagen. The name didn’t ring a bell with the front office staff. That’s when Kothe learnt his first lesson: Europe’s largest carmaker was a virtually unknown entity in India. Lesson No 2 was to follow soon. Kothe walked into the VW pavilion at the Expo but he couldn’t see any cars on display. Kothe panicked as the VW global board was scheduled to stopover. Then he realized why he couldn’t see the cars: they were all covered in dust. Over the next couple of hours he scurried around and got the place spick and span—in the nick of time before the board visit. Kothe’s second takeaway: if VW has to get it right in the country, it needs to marry German planning with Indian ingenuity. By all accounts, VW has been getting better at that endeavour with every passing year. It entered India late, but in just four years since it set up India operations, the German carmaker has sold a little over 1 lakh cars (till October 2011). Its seven models of compacts, sedans, and luxury cars have helped VW carve out a 3.5% market share—something the Detroit giants have not been able to do after more than a decade in the country. What’s more, the VW group is not a one-horse wonder. Globally, it owns a clutch of marquee auto names, from Audi, Bentley, and Lamborghini to Porsche, SEAT, and Skoda. In India, the group is present with three of these brands—Skoda came in first a decade ago, and Audi and VW hit Indian roads in 2007. The troika has still to collectively pull its weight in the group’s quest to become a carmaker to reckon with. But if ever there was a time to get the show on the road, it is now. The current slowdown notwithstanding, demand for and interest in passenger vehicles-from small cars to high-end luxury coupes-have heightened. That has emboldened the VW group to consider getting in more of its brands into the country-one-time Spanish auto major SEAT is likely to be brought in under the VW umbrella, as are luxury brands Porsche and Lamborghini (currently, they are imported by independent dealers). The Long Road Ahead Even as things stand today, the presence and power of multiple brands—VW, Skoda, and Audi—gives VW a distinct edge over many of its multinational competitors. ‘No other car maker with every model being so distinct,’ says John Chacko, VW group chief representative for India. ‘But naturally it will be the core brand that will have a lot of load on itself, in terms of (absorbing) investment, suppliers and volumes,’ adds Chacko. Backed by hatchback Polo and sedan Vento, the ‘core brand’s’ sales jumped 10-fold in 2010 to 32,627 units over a year ago. Till October 2011, that figure had more than doubled to a little over 66,000. Like most global carmakers, VW has adopted a top-down strategy, entering with the Passat and the Jetta (a large and a small family car, respectively). But it was only after the entry of the Polo (in early 2010) and the Vento (in mid-2010) that the pace of VW’s sales quickened. The company is now eyeing a market share of 10% by 2015. A chunk of that growth will come from the launch of the compact car up in a segment one rung lower than the Polo, by early 2013, benefits across the three brands. One synergy is in manufacturing. In 2006, VW invested Rs 3,300 crore in a factory in Chakan on the outskirts of Pune to produce the high-volume Polo and Vento. The unit, which can produce 1,30,000 units annually, also makes the premium compact, the Skoda Fabia, and will also roll out the soon-to-be-launched Skoda Rapid sedan.

Margaretha Anna Sophia Meyboom werd op 29 juli 1856 in Amsterdam geboren als tweede dochter in een domineesgezin. Haar ouders Angenis Henriette Frederika Tydeman (1828-1898) en Louis Susan Pedro Meyboom (1817-1874) hadden in totaal acht kinderen. De ouderlijke omgeving en vooral haar vader hadden een grote invloed op Meybooms leven en werk. Haar vader legde de basis voor haar twee grote passies, maatschappelijk engagement en interesse in het Noorden. Enerzijds was L.S.P. Meyboom een pionier op het gebied van moderne theologie, anderzijds was hij ook zeer geïnteresseerd in oude, heidense religies en schreef hij onder meer het boek De godsdienst der oude Noormannen1, waaruit hij zijn kinderen voorlas. Dit boek lijkt het beginpunt te zijn geweest voor Margaretha’s literaire interesse. In navolging van haar vader – hij had Deens geleerd door middel van vergelijkende bijbelstudies – begon Margaretha zichzelf op zeventienjarige leeftijd Deens te leren met behulp van een Deense grammatica en andere Scandinavische boeken die ze in de bibliotheek van haar vader had gevonden. De dominee van de Noorse Zeemanskerk hielp haar met de uitspraak.2 Al snel begon Meyboom ook vertalingen te maken van verhalen uit deze boeken, die ze opstuurde naar het dagblad Het Nieuws van den Dag, waar ze als feuilleton werden gepubliceerd. Zo werd de vertaalster geboren. Vermoedelijk is haar eerste gepubliceerde vertaling “Filia maris” van de Deen Johanne Schjørring (1836-1910) in 1880. Meybooms eerste vertalingen verschenen onder het pseudoniem Urda (een van de Noordse godinnen van het lot). Vanaf het moment dat ze hele boeken begon te vertalen – in 1891 als eerste Judas van Tor Hedberg (1862-1931) – publiceerde ze onder haar eigen naam. In totaal heeft Meyboom meer dan vijftig werken van Scandinavische auteurs vertaald. Met uitzondering van de Zweedse Selma Lagerlöf (1858-1940) en Tor Hedberg (1862-1931), waren dit Deense en Noorse auteurs, onder wie de Noren Bjørnstjerne Bjørnson (1832-1910), Henrik Ibsen (1828-1906), Knut Hamsun (1860-1952), Alexander Kielland (1849-1906), Arne Garborg (1851-1924), de Denen Carl Ewald (1856-1908), Adda Ravnkilde (1862-1883), en vele anderen. Ze liet het Nederlandse publiek kennismaken met de moderne literaire en sociale ideeën van Scandinavische schrijvers zoals Ibsen, Bjørnson en Lagerlöf.

Throughout the 1980s, while the molecule collectors were busy exploring the ocean sediments, tracking their finds into the past, and learning to read the messages hidden in the carbon skeletons, one analytical chemist cum geochemist at Indiana University was finding that important elements of the lexicon lay not only in the molecular structures, stereochemistry, and distributions of the carbon skeletons, but in the carbon atoms themselves. John Hayes had done his graduate work at MIT in the mid-1960s under Klaus Biemann, one of the doyens of mass spectrometry who, like Carl Djerassi, was interested in natural products with biomedical applications. When Hayes told Biemann he wanted to do his doctoral thesis on the organic constituents in meteorites, Biemann was uninterested, to say the least. Forty years later, Hayes can still quote the eminent scientist’s response to his proposal, replete with thick Austrian accent: “Don’t talk to me about zat junk.” Biemann walked away from the discussion without another word, and Hayes was so mortified by his own foolishness that he couldn’t bring himself to tell his wife about the incident. When he went into the lab the next day, he was convinced that his graduate career was over—but Biemann had done some homework and had a change of heart. “It seems we can get lots of money for zat junk!” he exclaimed as soon as he saw Hayes. NASA was, at the time, offering generous funding for such projects. For all his skepticism, Biemann was eventually seduced by the extraterrestrial “junk” and even ended up designing the mass spectrometer for the Viking Mars mission. Hayes remembers him commenting, a couple of years into the meteorite project, that it was actually “much more interesting than the thousandth alkaloid in the thousandth tree,” though Hayes himself says his doctoral thesis was unexceptional, completed before the Murchison meteorite fell and things really got interesting.

The Democratic Party’s 2008 presidential nomination was supposed to be the inevitable coronation of Hillary Clinton. She was the most well-known candidate; had the most support from the party establishment, and had, by far, the most financial resources. Two big names (Al Gore and John Kerry) considered running, but decided they had no hope of defeating the Clinton machine. That left an unlikely assortment of lesser-knowns: a U.S. Representative from Ohio (Dennis Kucinich), the Governor of New Mexico (Bill Richardson), and several U.S. Senators: Joe Biden (Delaware), John Edwards (North Carolina), Chris Dodd (Connecticut), Mike Gravel (Alaska), and Barack Obama (Illinois). The nomination went off script. Obama was a first-term senator, a black man with an unhelpful name, but he excited voters. He raised enough money to be competitive in the Iowa caucuses and he persuaded Oprah Winfrey to campaign for him. Obama defeated Clinton by eight percentage points in Iowa and the race was on. Obama won the Democratic nomination and, then, the presidential election against Republican John McCain because the Obama campaign had a lot more going for it than Obama’s eloquence and charisma: Big Data. The Obama campaign tried to put every potential voter into its data base, along with hundreds of tidbits of personal information: age, gender, marital status, race, religion, address, occupation, income, car registrations, home value, donation history, magazine subscriptions, leisure activities, Facebook friends, and anything else they could find that seemed relevant. Some data were collected from public data bases, some from e-mail exchanges or campaign workers knocking on front doors. Some data were purchased from private data vendors. Layered on top were weekly telephone surveys of thousands of potential voters which not only gathered personal data, but also attempted to gauge each person’s likelihood of voting—and voting for Obama. These voter likelihoods were correlated statistically with personal characteristics and extrapolated to other potential voters based on their personal characteristics. The campaign’s computer software predicted how likely each person its data base was to vote and the probability that the vote would be for Obama. This data-driven model allowed the campaign to microtarget individuals through e-mails, snail mail, personal visits, and television ads asking for donations and votes.