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Journal articles on the topic 'Lothian Birth Cohort'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Deary, I. J., A. J. Gow, A. Pattie, and J. M. Starr. "Cohort Profile: The Lothian Birth Cohorts of 1921 and 1936." International Journal of Epidemiology 41, no. 6 (2011): 1576–84. http://dx.doi.org/10.1093/ije/dyr197.

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2

Hamilton, Gillian, Sarah E. Harris, Gail Davies, et al. "Alzheimer's Disease Genes Are Associated with Measures of Cognitive Ageing in the Lothian Birth Cohorts of 1921 and 1936." International Journal of Alzheimer's Disease 2011 (2011): 1–11. http://dx.doi.org/10.4061/2011/505984.

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Alzheimer's disease patients have deficits in specific cognitive domains, and susceptibility genes for this disease may influence human cognition in nondemented individuals. To evaluate the role of Alzheimer's disease-linked genetic variation on cognition and normal cognitive ageing, we investigated two Scottish cohorts for which assessments in major cognitive domains are available: the Lothian Birth Cohort of 1921 and the Lothian Birth Cohort of 1936, consisting of 505 and 998 individuals, respectively. 158 SNPs from eleven genes were evaluated. Single SNP analyses did not reveal any statisti

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3

Taylor, Adele M., Alison Pattie, and Ian J. Deary. "Cohort Profile Update: The Lothian Birth Cohorts of 1921 and 1936." International Journal of Epidemiology 47, no. 4 (2018): 1042–1042. http://dx.doi.org/10.1093/ije/dyy022.

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4

Corley, Janie, John M. Starr, and Ian J. Deary. "Serum cholesterol and cognitive functions: the Lothian Birth Cohort 1936." International Psychogeriatrics 27, no. 3 (2014): 439–53. http://dx.doi.org/10.1017/s1041610214001197.

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ABSTRACTBackground:We examined the associations between serum cholesterol measures, statin use, and cognitive function measured in childhood and in old age. The possibility that lifelong (trait) cognitive ability accounts for any cross-sectional associations between cholesterol and cognitive performance in older age, seen in observational studies, has not been tested to date.Methods:Participants were 1,043 men and women from the Lothian Birth Cohort 1936 Study, most of whom had participated in a nationwide IQ-type test in childhood (Scottish Mental Survey of 1947), and were followed up at abou

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5

von Stumm, Sophie, and Ian J. Deary. "Intellect and cognitive performance in the Lothian Birth Cohort 1936." Psychology and Aging 28, no. 3 (2013): 680–84. http://dx.doi.org/10.1037/a0033924.

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6

Starr, J. M., A. Pattie, L. J. Whalley, and I. J. Deary. "Predictors of tooth loss in the 1921 Lothian Birth Cohort." Age and Ageing 37, no. 1 (2007): 111–14. http://dx.doi.org/10.1093/ageing/afm160.

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7

Booth, Tom, Rene Mõttus, Janie Corley, et al. "Personality, health, and brain integrity: The Lothian Birth Cohort Study 1936." Health Psychology 33, no. 12 (2014): 1477–86. http://dx.doi.org/10.1037/hea0000012.

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8

Welstead, Miles, Michelle Luciano, Graciela Muniz-Terrera, Adele M. Taylor, and Tom C. Russ. "Prevalence of Mild Cognitive Impairment in the Lothian Birth Cohort 1936." Alzheimer Disease & Associated Disorders 35, no. 3 (2021): 230–36. http://dx.doi.org/10.1097/wad.0000000000000433.

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9

Cox, Simon R., Mike Allerhand, Stuart J. Ritchie та ін. "Longitudinal serum S100β and brain aging in the Lothian Birth Cohort 1936". Neurobiology of Aging 69 (вересень 2018): 274–82. http://dx.doi.org/10.1016/j.neurobiolaging.2018.05.029.

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10

Gow, Alan J., Janie Corley, John M. Starr, and Ian J. Deary. "Reverse causation in activity-cognitive ability associations: The Lothian Birth Cohort 1936." Psychology and Aging 27, no. 1 (2012): 250–55. http://dx.doi.org/10.1037/a0024144.

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11

Starr, J. M., A. Kilgour, A. Pattie, A. Gow, T. C. Bates, and I. J. Deary. "Height and intelligence in the Lothian Birth Cohort 1921: a longitudinal study." Age and Ageing 39, no. 2 (2010): 272–75. http://dx.doi.org/10.1093/ageing/afp258.

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12

Sibbett, Ruth A., Tom C. Russ, Alison Pattie, John M. Starr, and Ian J. Deary. "Does incipient dementia explain normal cognitive decline determinants? Lothian birth cohort 1921." Psychology and Aging 33, no. 4 (2018): 674–84. http://dx.doi.org/10.1037/pag0000241.

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13

Paterson, Lindsay, Alan J. Gow, and Ian J. Deary. "School reform and opportunity throughout the lifecourse: the Lothian Birth Cohort 1936." School Effectiveness and School Improvement 25, no. 1 (2013): 105–25. http://dx.doi.org/10.1080/09243453.2013.772903.

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14

Henderson, Ross D., Michael Allerhand, Niall Patton, et al. "Vision and intelligence at age 83 in the Lothian Birth Cohort 1921." Intelligence 39, no. 2-3 (2011): 148–54. http://dx.doi.org/10.1016/j.intell.2011.02.005.

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15

McGrory, Sarah, Lucia Ballerini, Judith A. Okely, et al. "Retinal microvascular features and cognitive change in the Lothian‐Birth Cohort 1936." Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring 11, no. 1 (2019): 500–509. http://dx.doi.org/10.1016/j.dadm.2019.04.012.

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16

McIntosh, A. M., M. E. Bastin, M. Luciano, et al. "Neuroticism, depressive symptoms and white-matter integrity in the Lothian Birth Cohort 1936." Psychological Medicine 43, no. 6 (2012): 1197–206. http://dx.doi.org/10.1017/s003329171200150x.

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BackgroundClinical depression is associated with reductions in white-matter integrity in several long tracts of the brain. The extent to which these findings are localized or related to depressive symptoms or personality traits linked to disease risk remains unclear.MethodMembers of the Lothian Birth Cohort 1936 (LBC936) were assessed in two waves at mean ages of 70 and 73 years. At wave 1, they underwent assessments of depressive symptoms and the personality traits of neuroticism and extraversion. Brain diffusion magnetic resonance imaging (MRI) data were obtained at the second wave and mood

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17

McLachlan, Kyle J. J., James H. Cole, Sarah E. Harris, Riccardo E. Marioni, Ian J. Deary, and Catharine R. Gale. "Attitudes to ageing, biomarkers of ageing and mortality: the Lothian Birth Cohort 1936." Journal of Epidemiology and Community Health 74, no. 4 (2020): 377–83. http://dx.doi.org/10.1136/jech-2019-213462.

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ObjectiveTo investigate whether people with more positive attitudes to ageing are biologically younger as defined by leucocyte telomere length, accelerated DNA methylation GrimAge (AgeAccelGrim) and brain-predicted age difference, and whether these biomarkers explain relationships between attitudes to ageing and mortality.MethodsWe used linear regression to examine cross-sectionally attitudes to ageing (measured using the Attitudes to Ageing Questionnaire) and the three biomarkers in 758 adults, mean age 72.5 years, from the Lothian Birth Cohort 1936. We used Cox proportional hazards models to

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18

Okely, Judith A., and Ian J. Deary. "Associations Between Declining Physical and Cognitive Functions in the Lothian Birth Cohort 1936." Journals of Gerontology: Series A 75, no. 7 (2020): 1393–402. http://dx.doi.org/10.1093/gerona/glaa023.

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Abstract Background The ageing process is characterized by declines in physical and cognitive function. However, the relationship between these trajectories remains a topic of investigation. Methods Using four data waves collected triennially between ages 70 and 79, we tested for associations between multiple cognitive ability domains (verbal memory, processing speed, and visuospatial ability) and physical functions (walking speed, grip strength, and lung function). We first tested for associations between linear declines in physical and cognitive functions over the entire 9-year study period,

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19

Okely, Judith A., and Ian J. Deary. "Longitudinal Associations Between Loneliness and Cognitive Ability in the Lothian Birth Cohort 1936." Journals of Gerontology: Series B 74, no. 8 (2018): 1376–86. http://dx.doi.org/10.1093/geronb/gby086.

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Abstract Objectives Loneliness is associated with poorer cognitive function in old age; however, the direction of this association is unknown. We tested for reciprocal associations between loneliness and the cognitive ability domains of processing speed, visuospatial ability, verbal memory, and crystallized ability. Method We used three triennial waves of longitudinal data from the Lothian Birth Cohort Study 1936, and tested for cross-lagged associations between loneliness and cognitive abilities using cross-lagged panel models. Results Better processing speed, visuospatial ability, or crystal

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20

Houlihan, L. M., S. E. Harris, M. Luciano, et al. "Replication study of candidate genes for cognitive abilities: the Lothian Birth Cohort 1936." Genes, Brain and Behavior 8, no. 2 (2009): 238–47. http://dx.doi.org/10.1111/j.1601-183x.2008.00470.x.

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21

Fawns-Ritchie, Chloe, John M. Starr, and Ian J. Deary. "Role of cognitive ability in the association between functional health literacy and mortality in the Lothian Birth Cohort 1936: a prospective cohort study." BMJ Open 8, no. 9 (2018): e022502. http://dx.doi.org/10.1136/bmjopen-2018-022502.

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ObjectivesWe investigated the role that childhood and old age cognitive ability play in the association between functional health literacy and mortality.DesignProspective cohort study.SettingThis study used data from the Lothian Birth Cohort 1936 (LBC1936) study, which recruited participants living in the Lothian region of Scotland when aged 70 years, most of whom had completed an intelligence test at age 11 years.Participants795 members of the LBC1936 with scores on tests of functional health literacy and cognitive ability in childhood and older adulthood.Primary and secondary outcome measure

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22

Corley, J., S. R. Cox, and I. J. Deary. "Healthy cognitive ageing in the Lothian Birth Cohort studies: marginal gains not magic bullet." Psychological Medicine 48, no. 2 (2017): 187–207. http://dx.doi.org/10.1017/s0033291717001489.

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In the face of shifting demographics and an increase in human longevity, it is important to examine carefully what is known about cognitive ageing, and to identify and promote possibly malleable lifestyle and health-related factors that might mitigate age-associated cognitive decline. The Lothian Birth Cohorts of 1921 (LBC1921, n = 550) and 1936 (LBC1936, n = 1091) are longitudinal studies of cognitive and brain ageing based in Scotland. Childhood IQ data are available for these participants, who were recruited in later life and then followed up regularly. This overview summarises some of the

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23

Harris, Sarah E., Carmen Martin-Ruiz, Thomas von Zglinicki, John M. Starr, and Ian J. Deary. "Telomere length and aging biomarkers in 70-year-olds: the Lothian Birth Cohort 1936." Neurobiology of Aging 33, no. 7 (2012): 1486.e3–1486.e8. http://dx.doi.org/10.1016/j.neurobiolaging.2010.11.013.

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24

Cox, Simon R., Mark E. Bastin, Karen J. Ferguson, et al. "Brain white matter integrity and cortisol in older men: the Lothian Birth Cohort 1936." Neurobiology of Aging 36, no. 1 (2015): 257–64. http://dx.doi.org/10.1016/j.neurobiolaging.2014.06.022.

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25

Corley, Janie, Xueli Jia, Caroline E. Brett, et al. "Alcohol intake and cognitive abilities in old age: The Lothian Birth Cohort 1936 study." Neuropsychology 25, no. 2 (2011): 166–75. http://dx.doi.org/10.1037/a0021571.

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26

Corley, Janie, Xueli Jia, Janet A. M. Kyle, et al. "Caffeine Consumption and Cognitive Function at Age 70: The Lothian Birth Cohort 1936 Study." Psychosomatic Medicine 72, no. 2 (2010): 206–14. http://dx.doi.org/10.1097/psy.0b013e3181c92a9c.

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27

Okely, Judith A., Michael A. Akeroyd, Michael Allerhand, John M. Starr, and Ian J. Deary. "Longitudinal associations between hearing loss and general cognitive ability: The Lothian Birth Cohort 1936." Psychology and Aging 34, no. 6 (2019): 766–79. http://dx.doi.org/10.1037/pag0000385.

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28

Schiepers, O. J. G., M. P. J. van Boxtel, S. E. Harris, et al. "MTHFR polymorphisms and cognitive ageing in the ninth decade: the Lothian Birth Cohort 1921." Genes, Brain and Behavior 10, no. 3 (2011): 354–64. http://dx.doi.org/10.1111/j.1601-183x.2010.00675.x.

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29

Murray, Catherine, Alison Pattie, John M. Starr, and Ian J. Deary. "Does cognitive ability predict mortality in the ninth decade? The Lothian Birth Cohort 1921." Intelligence 40, no. 5 (2012): 490–98. http://dx.doi.org/10.1016/j.intell.2012.05.003.

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30

Lyall, Donald M., Lorna M. Lopez, Mark E. Bastin, et al. "ADRB2, brain white matter integrity and cognitive ageing in the Lothian Birth Cohort 1936." Behavior Genetics 43, no. 1 (2012): 13–23. http://dx.doi.org/10.1007/s10519-012-9570-x.

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31

Altschul, Drew, John Starr, and Ian Deary. "Blood pressure and cognitive function across the eighth decade: a prospective study of the Lothian Birth Cohort of 1936." BMJ Open 10, no. 7 (2020): e033990. http://dx.doi.org/10.1136/bmjopen-2019-033990.

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ObjectivesWe investigated the associations among blood pressure and cognitive functions across the eighth decade, while accounting for antihypertensive medication and lifetime stability in cognitive function.DesignProspective cohort study.SettingThis study used data from the Lothian Birth Cohort 1936 (LBC1936) study, which recruited participants living in the Lothian region of Scotland when aged 70 years, most of whom had completed an intelligence test at age 11 years.Participants1091 members of the LBC1936 with assessments of cognitive ability in childhood and older adulthood, and blood press

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32

Valdés Hernández, Maria del Carmen, Simon R. Cox, Jaeil Kim, et al. "Hippocampal morphology and cognitive functions in community-dwelling older people: the Lothian Birth Cohort 1936." Neurobiology of Aging 52 (April 2017): 1–11. http://dx.doi.org/10.1016/j.neurobiolaging.2016.12.012.

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33

Dickie, David Alexander, Stuart J. Ritchie, Simon R. Cox, et al. "Vascular risk factors and progression of white matter hyperintensities in the Lothian Birth Cohort 1936." Neurobiology of Aging 42 (June 2016): 116–23. http://dx.doi.org/10.1016/j.neurobiolaging.2016.03.011.

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34

Gale, Catharine R., Stuart J. Ritchie, Cyrus Cooper, John M. Starr, and Ian J. Deary. "Cognitive Ability in Late Life and Onset of Physical Frailty: The Lothian Birth Cohort 1936." Journal of the American Geriatrics Society 65, no. 6 (2017): 1289–95. http://dx.doi.org/10.1111/jgs.14787.

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35

Aichele, Stephen, Paolo Ghisletta, Janie Corley, et al. "Fluid Intelligence Predicts Change in Depressive Symptoms in Later Life: The Lothian Birth Cohort 1936." Psychological Science 29, no. 12 (2018): 1984–95. http://dx.doi.org/10.1177/0956797618804501.

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We examined reciprocal, time-ordered associations between age-related changes in fluid intelligence and depressive symptoms. Participants were 1,091 community-dwelling older adults from the Lothian Birth Cohort 1936 study who were assessed repeatedly at 3-year intervals between the ages of 70 and 79 years. On average, fluid intelligence and depressive symptoms worsened with age. There was also a dynamic-coupling effect, in which low fluid intelligence at a given age predicted increasing depressive symptoms across the following 3-year interval, whereas the converse did not hold. Model compariso

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36

Gale, Catharine, Stuart J. Ritchie, John M. Starr, and Ian J. Deary. "Physical frailty and decline in general and specific cognitive abilities: the Lothian Birth Cohort 1936." Journal of Epidemiology and Community Health 74, no. 2 (2019): 108–13. http://dx.doi.org/10.1136/jech-2019-213280.

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BackgroundPhysical frailty is associated with many adverse outcomes including disability, chronic disease, hospitalisation, institutionalisation and death. It is unclear what impact it might have on the rate of normal cognitive ageing. We investigated whether physical frailty was related to initial level of, and change in, cognitive abilities from age 70 to 79 years.MethodParticipants were 950 members of the Lothian Birth Cohort 1936. Physical frailty was assessed at age 70 years using the Fried criteria. Cognitive function was assessed at ages 70, 73, 76 and 79 years. We used linear regressio

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37

Corley, Janie, Janet A. M. Kyle, John M. Starr, Geraldine McNeill, and Ian J. Deary. "Dietary factors and biomarkers of systemic inflammation in older people: the Lothian Birth Cohort 1936." British Journal of Nutrition 114, no. 7 (2015): 1088–98. http://dx.doi.org/10.1017/s000711451500210x.

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Epidemiological studies have reported inverse associations between various single healthy diet indices and lower levels of systemic inflammation, but rarely are they examined in the same sample. The aim of the present study was to investigate the potential relationships between biomarkers of systemic inflammation (C-reactive protein (CRP) and fibrinogen) and overall foods (dietary patterns), single foods (fruits and vegetables), and specific nutritive (antioxidants) and non-nutritive (flavonoids) food components in the same narrow-age cohort of older adults. The dietary intake of 792 participa

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38

Welstead, Miles, Michelle Luciano, Graciela Muniz-Terrera, Stina Saunders, Donncha S. Mullin, and Tom C. Russ. "Predictors of Mild Cognitive Impairment Stability, Progression, or Reversion in the Lothian Birth Cohort 1936." Journal of Alzheimer's Disease 80, no. 1 (2021): 225–32. http://dx.doi.org/10.3233/jad-201282.

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Background: Mild cognitive impairment (MCI) describes a borderland between healthy cognition and dementia. Progression to and reversion from MCI is relatively common but more research is required to understand the factors affecting this fluidity and improve clinical care interventions. Objective: We explore these transitions in MCI status and their predictive factors over a six-year period in a highly-phenotyped longitudinal study, the Lothian Birth Cohort 1936. Methods: MCI status was derived in the LBC1936 at ages 76 (n = 567) and 82 years (n = 341) using NIA-AA diagnostic guidelines. Progre

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39

Taylor, Adele M., Danielle Page, Judith A. Okely, et al. "Impact of COVID-19 lockdown on psychosocial factors, health, and lifestyle in Scottish octogenarians: The Lothian Birth Cohort 1936 study." PLOS ONE 16, no. 6 (2021): e0253153. http://dx.doi.org/10.1371/journal.pone.0253153.

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Background Little is known about effects of COVID-19 lockdown on psychosocial factors, health and lifestyle in older adults, particularly those aged over 80 years, despite the risks posed by COVID-19 to this age group. Methods Lothian Birth Cohort 1936 members, residing mostly in Edinburgh and the surrounding Lothians regions in Scotland, mean age 84 years (SD = 0.3), responded to an online questionnaire in May 2020 (n = 190). We examined responses (experience and knowledge of COVID-19; adherence to guidance; impact on day-to-day living; social contact; self-reported physical and mental health

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40

Gale, C. R., A. Aihie Sayer, C. Cooper, et al. "Factors associated with symptoms of anxiety and depression in five cohorts of community-based older people: the HALCyon (Healthy Ageing across the Life Course) Programme." Psychological Medicine 41, no. 10 (2011): 2057–73. http://dx.doi.org/10.1017/s0033291711000195.

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BackgroundSymptoms of anxiety and depression are common in older people, but the relative importance of factors operating in early and later life in influencing risk is unclear, particularly in the case of anxiety.MethodWe used data from five cohorts in the Healthy Ageing across the Life Course (HALCyon) collaborative research programme: the Aberdeen Birth Cohort 1936, the Caerphilly Prospective Study, the Hertfordshire Ageing Study, the Hertfordshire Cohort Study and the Lothian Birth Cohort 1921. We used logistic regression to examine the relationship between factors from early and later lif

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41

Cherrie, Mark P. C., Niamh K. Shortt, Richard J. Mitchell, et al. "Green space and cognitive ageing: A retrospective life course analysis in the Lothian Birth Cohort 1936." Social Science & Medicine 196 (January 2018): 56–65. http://dx.doi.org/10.1016/j.socscimed.2017.10.038.

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42

Aribisala, Benjamin S., Maria C. Valdés Hernández, Natalie A. Royle, et al. "Brain atrophy associations with white matter lesions in the ageing brain: the Lothian Birth Cohort 1936." European Radiology 23, no. 4 (2012): 1084–92. http://dx.doi.org/10.1007/s00330-012-2677-x.

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43

Starr, J. M., and I. J. Deary. "Blood pressure, socio-economic status and health in the Lothian 1921 birth cohort: A longitudinal study." Public Health 125, no. 4 (2011): 196–200. http://dx.doi.org/10.1016/j.puhe.2010.11.017.

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44

Butchart, Catherine, Janet Kyle, Geraldine McNeill, et al. "Flavonoid intake in relation to cognitive function in later life in the Lothian Birth Cohort 1936." British Journal of Nutrition 106, no. 1 (2011): 141–48. http://dx.doi.org/10.1017/s0007114510005738.

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Previous studies have suggested a link between flavonoid intake and better cognitive function in later life but have not been able to control for possible confounding by prior intelligence quotient (IQ). The aim of the present study was to address this issue in a cross-sectional survey of 1091 men and women born in 1936, in whom IQ was measured at age 11 years. At the age of 70 years, participants carried out various neuropsychological tests and completed a FFQ. Associations between test scores and nutrient intake were assessed by linear regression with adjustment for potentially confounding v

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45

von Stumm, Sophie, and Ian J. Deary. "Typical intellectual engagement and cognition in the ninth decade of life: The Lothian Birth Cohort 1921." Psychology and Aging 27, no. 3 (2012): 761–67. http://dx.doi.org/10.1037/a0026527.

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46

Marioni, Riccardo E., Sonia Shah, Allan F. McRae, et al. "The epigenetic clock is correlated with physical and cognitive fitness in the Lothian Birth Cohort 1936." International Journal of Epidemiology 44, no. 4 (2015): 1388–96. http://dx.doi.org/10.1093/ije/dyu277.

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47

Lyall, Donald M., Natalie A. Royle, Sarah E. Harris, et al. "Alzheimer’s Disease Susceptibility Genes APOE and TOMM40, and Hippocampal Volumes in the Lothian Birth Cohort 1936." PLoS ONE 8, no. 11 (2013): e80513. http://dx.doi.org/10.1371/journal.pone.0080513.

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48

Taylor, Adele M., Stuart J. Ritchie, Ciara Madden, and Ian J. Deary. "Associations between Brief Resilience Scale scores and ageing-related domains in the Lothian Birth Cohort 1936." Psychology and Aging 35, no. 3 (2020): 329–44. http://dx.doi.org/10.1037/pag0000419.

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49

Cadar, Dorina, Annie Robitaille, Alison Pattie, Ian J. Deary, and Graciela Muniz-Terrera. "The long arm of childhood intelligence on terminal decline: Evidence from the Lothian Birth Cohort 1921." Psychology and Aging 35, no. 6 (2020): 806–17. http://dx.doi.org/10.1037/pag0000477.

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50

Welstead, Miles, Graciela Muniz-Terrera, Tom C. Russ, et al. "Inflammation as a risk factor for the development of frailty in the Lothian Birth Cohort 1936." Experimental Gerontology 139 (October 2020): 111055. http://dx.doi.org/10.1016/j.exger.2020.111055.

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