Relevant bibliographies by topics / Lovastatin Hydroxy Acid

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Academic literature on the topic 'Lovastatin Hydroxy Acid'

Author: Grafiati
Published: 5 June 2025
Last updated: 2 August 2025

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Journal articles on the topic "Lovastatin Hydroxy Acid"

1

S, Jana. "The Biofield Energy Treatment and its Effect on the Relative Oral Bioavailability of Lovastatin Hydroxy Acid in Rats after a Single Oral Dose of Lovastatin." Bioequivalence & Bioavailability International Journal 5, no. 1 (2021): 1–8. http://dx.doi.org/10.23880/beba-16000150.

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Lovastatin is a lipid-lowering drug used to reduce the risk of cardiovascular disease. Lovastatin shows poor oral bioavailability (<5%) because of its low water solubility and short half-life. Therefore, the present study was performed to determine the effects of the Trivedi Effect ® - Consciousness Energy Treatment (Blessing) on lovastatin and rats through the measurement of plasma lovastatin hydroxy acid concentrations after the oral administration of lovastatin in rats. The test item, lovastatin was divided into two parts. One part was denoted as the control, while the other part was def
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2

Trivedi, Dahryn, and Snehasis Jana. "The Biofield Energy Treatment and its Effect on the Relative Oral Bioavailability of Lovastatin Hydroxy Acid in Rats after a Single Oral Dose of Lovastatin." Bioequivalence & Bioavailability International Journal (BEBA) 5, no. 1 (2021): 1–8. https://doi.org/10.5281/zenodo.10362325.

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Lovastatin is a lipid-lowering drug used to reduce the risk of cardiovascular disease. Lovastatin shows poor oral bioavailability (<5%) because of its low water solubility and short half-life. Therefore, the present study was performed to determine the effects of the Trivedi Effect®- Consciousness Energy Treatment (Blessing) on lovastatin and rats through the measurement of plasma lovastatin hydroxy acid concentrations after the oral administration of lovastatin in rats. The test item, lovastatin was divided into two parts. One part was denoted as the control, while the other part was defin
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3

Vree, Tom B., Erik Dammers, Ivan Ulc, Stefan Horkovics-Kovats, Miroslav Ryska, and IJsbrand Merkx. "Differences Between Lovastatin and Simvastatin Hydrolysis in Healthy Male and Female Volunteers: Gut Hydrolysis of Lovastatin is Twice that of Simvastatin." Scientific World JOURNAL 3 (2003): 1332–43. http://dx.doi.org/10.1100/tsw.2003.121.

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The aim of this pharmacokinetic evaluation was to show the effect of the extra methyl group in simvastatin on esterase hydrolysis between lovastatin and simvastatin in male and female volunteers. This study was based on the plasma concentration-time curves and the pharmacokinetics of lovastatin and simvastatin with its respective active metabolite statin-β-hydroxy acid obtained from two different bioequivalence studies, each with 18 females and 18 males. Results were: 1-The group of female volunteers showed a higher yield of the active metabolite β-hydroxy acid than the group of males (p <
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4

Wagmann, Lea, Selina Hemmer, Achim T. Caspar, and Markus R. Meyer. "Method development for quantitative determination of seven statins including four active metabolites by means of high-resolution tandem mass spectrometry applicable for adherence testing and therapeutic drug monitoring." Clinical Chemistry and Laboratory Medicine (CCLM) 58, no. 5 (2020): 664–72. http://dx.doi.org/10.1515/cclm-2019-0763.

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AbstractBackgroundStatins are used to treat and prevent cardiovascular diseases (CVDs) by reducing the total serum cholesterol concentration. Unfortunately, dose-related side effects and sub-optimal response, attributed to non-adherence amongst others, were described. Therefore, a fast and sensitive liquid chromatography-high-resolution tandem mass spectrometry (LC-HRMS/MS) method for adherence testing and therapeutic drug monitoring of all currently marketed statins and their active metabolites in human blood plasma should be developed, validated and tested for applicability.MethodsAtorvastat
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5

Zhao, Qing, Mengxing Chen, Ling Zhou, Lili Zhao, Rong Yan, and Kesheng Dai. "Lovastatin Induces Platelet Apoptosis." Blood 124, no. 21 (2014): 5030. http://dx.doi.org/10.1182/blood.v124.21.5030.5030.

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Abstract Introduction Lovastatin, the inhibitors of 3-hydroxy 3-methylglutaryl coenzyme A (HMG-CoA) reductase, is widely used in treatments of coronary artery diseases. Lovastatin induces apoptosis in nucleate cells, such as macrophages, cancer cells, and skeletal muscle cells. Lovastatin has side effects of thrombocytopenia and hemorrhage, however, the possible pathogenesis of the side effects have still remained unknown. Methods and Results In this study, we found that collagen and thrombin-induced platelet aggregation was obviously reduced in platelets treated by lovastatin, while platelet
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6

Lodge, J. W., B. L. Fletcher, S. S. Brown, A. J. Parham, R. A. Fernando, and B. J. Collins. "Determination of Lovastatin Hydroxy Acid in Female B6C3F1 Mouse Serum." Journal of Analytical Toxicology 32, no. 3 (2008): 248–52. http://dx.doi.org/10.1093/jat/32.3.248.

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7

Hansen, Lee D., Delbert J. Eatough, Edwin A. Lewis, Robert G. Bergstrom, Damaris Degraft-Johnson, and Karen Cassidy-Thompson. "Shelf-life prediction from induction period calorimetric measurements on materials undergoing autocatalytic decomposition." Canadian Journal of Chemistry 68, no. 11 (1990): 2111–14. http://dx.doi.org/10.1139/v90-321.

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The shelf- or use-life of a material which decomposes by an autocatalytic reaction is shown to be inversely proportional to the rate of heat generation during the induction period of the degradation reaction. Calorimetric measurement of the rate of heat generation during the induction period takes only a few hours. It can often be done at or very near the actual storage or use temperature of the material. Measurements on Lovastatin (2-methylbutanoic acid 1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenylester) are used as an example of this
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8

Dimitroulakos, Jim, Dana Nohynek, Karen L. Backway, et al. "Increased Sensitivity of Acute Myeloid Leukemias to Lovastatin-Induced Apoptosis: A Potential Therapeutic Approach." Blood 93, no. 4 (1999): 1308–18. http://dx.doi.org/10.1182/blood.v93.4.1308.

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Abstract We recently demonstrated that 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, the rate-limiting enzyme of de novo cholesterol synthesis, was a potential mediator of the biological effects of retinoic acid on human neuroblastoma cells. The HMG-CoA reductase inhibitor, lovastatin, which is used extensively in the treatment of hypercholesterolemia, induced a potent apoptotic response in human neuroblastoma cells. This apoptotic response was triggered at lower concentrations and occurred more rapidly than had been previously reported in other tumor-derived cell lines, including
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9

Dimitroulakos, Jim, Dana Nohynek, Karen L. Backway, et al. "Increased Sensitivity of Acute Myeloid Leukemias to Lovastatin-Induced Apoptosis: A Potential Therapeutic Approach." Blood 93, no. 4 (1999): 1308–18. http://dx.doi.org/10.1182/blood.v93.4.1308.404k08_1308_1318.

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We recently demonstrated that 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, the rate-limiting enzyme of de novo cholesterol synthesis, was a potential mediator of the biological effects of retinoic acid on human neuroblastoma cells. The HMG-CoA reductase inhibitor, lovastatin, which is used extensively in the treatment of hypercholesterolemia, induced a potent apoptotic response in human neuroblastoma cells. This apoptotic response was triggered at lower concentrations and occurred more rapidly than had been previously reported in other tumor-derived cell lines, including breast a
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10

Ju, Zhiguo, та Eric A. Curry. "Lovastatin Inhibition of α-Farnesene Production in Ripening Apple: Precursor Feeding Studies". Journal of the American Society for Horticultural Science 126, № 4 (2001): 491–95. http://dx.doi.org/10.21273/jashs.126.4.491.

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Effects of α-farnesene biosynthesis precursors on α-farnesene and ethylene production were studied using Lovastatin-treated or nontreated `Delicious' and `Granny Smith' apples [Malus sylvestris (L.) Mill. var. domestica (Borkh.) Mansf.]. In nontreated fruit, α-farnesene was detected only in fruit peel (≈3 mm) and not in the more proximal cortical tissue. α-Farnesene was not detectable in preclimacteric fruit peel at harvest. Mevalonic acid lactone (MAL) or farnesyl pyrophosphate (FPP) induced α-farnesene production when fed to preclimacteric peel tissue, but hydroxymethylglutaric acid (HMG) di
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Book chapters on the topic "Lovastatin Hydroxy Acid"

1

"Avoid Protecting Groups." In Green Chemistry: Principles and Case Studies. The Royal Society of Chemistry, 2019. http://dx.doi.org/10.1039/bk9781788017985-00237.

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Protecting groups have become standard in organic synthesis, yet they contribute to synthetic inefficiency, adding two extra steps for each protecting group—putting it on and taking it off. Protecting groups can be categorized in several ways. Here, we have grouped them according to the conditions used to remove them: acid, base, fluoride, Pd, hydrogenation, or oxidation labile. Different functional groups have different reactivities that must be considered in designing a synthesis. Protic acids, α-carbon acids, electrophiles, and bases/nucleophiles each require different consideration. In the
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