Log in

Relevant bibliographies by topics / Lovastatin Hydroxy Acid / Journal articles

To see the other types of publications on this topic, follow the link: Lovastatin Hydroxy Acid.

Journal articles on the topic 'Lovastatin Hydroxy Acid'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 39 journal articles for your research on the topic 'Lovastatin Hydroxy Acid.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

S, Jana. "The Biofield Energy Treatment and its Effect on the Relative Oral Bioavailability of Lovastatin Hydroxy Acid in Rats after a Single Oral Dose of Lovastatin." Bioequivalence & Bioavailability International Journal 5, no. 1 (2021): 1–8. http://dx.doi.org/10.23880/beba-16000150.

Full text

Abstract:

Lovastatin is a lipid-lowering drug used to reduce the risk of cardiovascular disease. Lovastatin shows poor oral bioavailability (<5%) because of its low water solubility and short half-life. Therefore, the present study was performed to determine the effects of the Trivedi Effect ® - Consciousness Energy Treatment (Blessing) on lovastatin and rats through the measurement of plasma lovastatin hydroxy acid concentrations after the oral administration of lovastatin in rats. The test item, lovastatin was divided into two parts. One part was denoted as the control, while the other part was def

APA, Harvard, Vancouver, ISO, and other styles

2

Trivedi, Dahryn, and Snehasis Jana. "The Biofield Energy Treatment and its Effect on the Relative Oral Bioavailability of Lovastatin Hydroxy Acid in Rats after a Single Oral Dose of Lovastatin." Bioequivalence & Bioavailability International Journal (BEBA) 5, no. 1 (2021): 1–8. https://doi.org/10.5281/zenodo.10362325.

Full text

Abstract:

Lovastatin is a lipid-lowering drug used to reduce the risk of cardiovascular disease. Lovastatin shows poor oral bioavailability (<5%) because of its low water solubility and short half-life. Therefore, the present study was performed to determine the effects of the Trivedi Effect®- Consciousness Energy Treatment (Blessing) on lovastatin and rats through the measurement of plasma lovastatin hydroxy acid concentrations after the oral administration of lovastatin in rats. The test item, lovastatin was divided into two parts. One part was denoted as the control, while the other part was defin

APA, Harvard, Vancouver, ISO, and other styles

3

Vree, Tom B., Erik Dammers, Ivan Ulc, Stefan Horkovics-Kovats, Miroslav Ryska, and IJsbrand Merkx. "Differences Between Lovastatin and Simvastatin Hydrolysis in Healthy Male and Female Volunteers: Gut Hydrolysis of Lovastatin is Twice that of Simvastatin." Scientific World JOURNAL 3 (2003): 1332–43. http://dx.doi.org/10.1100/tsw.2003.121.

Full text

Abstract:

The aim of this pharmacokinetic evaluation was to show the effect of the extra methyl group in simvastatin on esterase hydrolysis between lovastatin and simvastatin in male and female volunteers. This study was based on the plasma concentration-time curves and the pharmacokinetics of lovastatin and simvastatin with its respective active metabolite statin-β-hydroxy acid obtained from two different bioequivalence studies, each with 18 females and 18 males. Results were: 1-The group of female volunteers showed a higher yield of the active metabolite β-hydroxy acid than the group of males (p <

APA, Harvard, Vancouver, ISO, and other styles

4

Wagmann, Lea, Selina Hemmer, Achim T. Caspar, and Markus R. Meyer. "Method development for quantitative determination of seven statins including four active metabolites by means of high-resolution tandem mass spectrometry applicable for adherence testing and therapeutic drug monitoring." Clinical Chemistry and Laboratory Medicine (CCLM) 58, no. 5 (2020): 664–72. http://dx.doi.org/10.1515/cclm-2019-0763.

Full text

Abstract:

AbstractBackgroundStatins are used to treat and prevent cardiovascular diseases (CVDs) by reducing the total serum cholesterol concentration. Unfortunately, dose-related side effects and sub-optimal response, attributed to non-adherence amongst others, were described. Therefore, a fast and sensitive liquid chromatography-high-resolution tandem mass spectrometry (LC-HRMS/MS) method for adherence testing and therapeutic drug monitoring of all currently marketed statins and their active metabolites in human blood plasma should be developed, validated and tested for applicability.MethodsAtorvastat

APA, Harvard, Vancouver, ISO, and other styles

5

Zhao, Qing, Mengxing Chen, Ling Zhou, Lili Zhao, Rong Yan, and Kesheng Dai. "Lovastatin Induces Platelet Apoptosis." Blood 124, no. 21 (2014): 5030. http://dx.doi.org/10.1182/blood.v124.21.5030.5030.

Full text

Abstract:

Abstract Introduction Lovastatin, the inhibitors of 3-hydroxy 3-methylglutaryl coenzyme A (HMG-CoA) reductase, is widely used in treatments of coronary artery diseases. Lovastatin induces apoptosis in nucleate cells, such as macrophages, cancer cells, and skeletal muscle cells. Lovastatin has side effects of thrombocytopenia and hemorrhage, however, the possible pathogenesis of the side effects have still remained unknown. Methods and Results In this study, we found that collagen and thrombin-induced platelet aggregation was obviously reduced in platelets treated by lovastatin, while platelet

APA, Harvard, Vancouver, ISO, and other styles

6

Lodge, J. W., B. L. Fletcher, S. S. Brown, A. J. Parham, R. A. Fernando, and B. J. Collins. "Determination of Lovastatin Hydroxy Acid in Female B6C3F1 Mouse Serum." Journal of Analytical Toxicology 32, no. 3 (2008): 248–52. http://dx.doi.org/10.1093/jat/32.3.248.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Hansen, Lee D., Delbert J. Eatough, Edwin A. Lewis, Robert G. Bergstrom, Damaris Degraft-Johnson, and Karen Cassidy-Thompson. "Shelf-life prediction from induction period calorimetric measurements on materials undergoing autocatalytic decomposition." Canadian Journal of Chemistry 68, no. 11 (1990): 2111–14. http://dx.doi.org/10.1139/v90-321.

Full text

Abstract:

The shelf- or use-life of a material which decomposes by an autocatalytic reaction is shown to be inversely proportional to the rate of heat generation during the induction period of the degradation reaction. Calorimetric measurement of the rate of heat generation during the induction period takes only a few hours. It can often be done at or very near the actual storage or use temperature of the material. Measurements on Lovastatin (2-methylbutanoic acid 1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenylester) are used as an example of this

APA, Harvard, Vancouver, ISO, and other styles

8

Dimitroulakos, Jim, Dana Nohynek, Karen L. Backway, et al. "Increased Sensitivity of Acute Myeloid Leukemias to Lovastatin-Induced Apoptosis: A Potential Therapeutic Approach." Blood 93, no. 4 (1999): 1308–18. http://dx.doi.org/10.1182/blood.v93.4.1308.

Full text

Abstract:

Abstract We recently demonstrated that 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, the rate-limiting enzyme of de novo cholesterol synthesis, was a potential mediator of the biological effects of retinoic acid on human neuroblastoma cells. The HMG-CoA reductase inhibitor, lovastatin, which is used extensively in the treatment of hypercholesterolemia, induced a potent apoptotic response in human neuroblastoma cells. This apoptotic response was triggered at lower concentrations and occurred more rapidly than had been previously reported in other tumor-derived cell lines, including

APA, Harvard, Vancouver, ISO, and other styles

9

Dimitroulakos, Jim, Dana Nohynek, Karen L. Backway, et al. "Increased Sensitivity of Acute Myeloid Leukemias to Lovastatin-Induced Apoptosis: A Potential Therapeutic Approach." Blood 93, no. 4 (1999): 1308–18. http://dx.doi.org/10.1182/blood.v93.4.1308.404k08_1308_1318.

Full text

Abstract:

We recently demonstrated that 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, the rate-limiting enzyme of de novo cholesterol synthesis, was a potential mediator of the biological effects of retinoic acid on human neuroblastoma cells. The HMG-CoA reductase inhibitor, lovastatin, which is used extensively in the treatment of hypercholesterolemia, induced a potent apoptotic response in human neuroblastoma cells. This apoptotic response was triggered at lower concentrations and occurred more rapidly than had been previously reported in other tumor-derived cell lines, including breast a

APA, Harvard, Vancouver, ISO, and other styles

10

Ju, Zhiguo, та Eric A. Curry. "Lovastatin Inhibition of α-Farnesene Production in Ripening Apple: Precursor Feeding Studies". Journal of the American Society for Horticultural Science 126, № 4 (2001): 491–95. http://dx.doi.org/10.21273/jashs.126.4.491.

Full text

Abstract:

Effects of α-farnesene biosynthesis precursors on α-farnesene and ethylene production were studied using Lovastatin-treated or nontreated `Delicious' and `Granny Smith' apples [Malus sylvestris (L.) Mill. var. domestica (Borkh.) Mansf.]. In nontreated fruit, α-farnesene was detected only in fruit peel (≈3 mm) and not in the more proximal cortical tissue. α-Farnesene was not detectable in preclimacteric fruit peel at harvest. Mevalonic acid lactone (MAL) or farnesyl pyrophosphate (FPP) induced α-farnesene production when fed to preclimacteric peel tissue, but hydroxymethylglutaric acid (HMG) di

APA, Harvard, Vancouver, ISO, and other styles

11

Beltrán, Riquelme David, Lisón María Dolores Frutos, Juan Carlos Espín та Villalba Rocio Garcia. "Re-examining the role of the gut microbiota in the conversion of the lipid-lowering statin monacolin K (lovastatin) into its active β-hydroxy acid metabolite". Food and Function 10, № 4 (2019): 1787–91. https://doi.org/10.1039/c8fo02594k.

Full text

Abstract:

Monacolin K (MK, lovastatin), a naturally occurring statin, only exerts lipid-lowering effects in its active β-hydroxy acid form (MKA). This activation was thought to be mediated by the gut microbiota (GM). We report here for the first time that the GM does not convert MK into MKA (a spontaneous pH-dependent conversion) but catabolises MKA. The GM might hamper the lipid-lowering effects by degrading the active metabolite MKA.

APA, Harvard, Vancouver, ISO, and other styles

12

Ju, Zhiguo, та Eric A. Curry. "Lovastatin Inhibits α-Farnesene Synthesis without Affecting Ethylene Production during Fruit Ripening in `Golden Supreme' Apples". Journal of the American Society for Horticultural Science 125, № 1 (2000): 105–10. http://dx.doi.org/10.21273/jashs.125.1.105.

Full text

Abstract:

Lovastatin is a specific hydroxymethylglutaryl coenzyme-A reductase inhibitor in animals and as such, is a potent cholesterol lowering pharmaceutical for human use. Because it has also been shown to inhibit α-farnesene in certain plants, we investigated its effects on ethylene and α-farnesene biosynthesis, volatile production, and fruit color during ripening in `Golden Supreme' apples [Malus sylvestris (L.) Mill. var. domestica (Borkh.) Mansf.]. Immediately after harvest, fruit were dipped in Lovastatin solution for 2 min, allowed to dry, and stored in the dark at 20 °C for 30 days. Internal e

APA, Harvard, Vancouver, ISO, and other styles

13

Lambert, Marie, Paul-J. Lupien, Claude Gagné, et al. "Treatment of Familial Hypercholesterolemia in Children and Adolescents: Effect of Lovastatin." Pediatrics 97, no. 5 (1996): 619–28. http://dx.doi.org/10.1542/peds.97.5.619.

Full text

Abstract:

Objective. Familial hypercholesterolemia (FH), an inherited autosomal dominant disorder of lipoprotein metabolism, is associated with premature atherosclerosis. The recommended pediatric therapy consists of dietary intervention and, when necessary, treatment with bile acid-binding resins. However, compliance has been poor in many children. Therefore, our objectives were to determine the efficacy, safety, and tolerance of the short-term use of lovastatin, a 3-hydroxy 3-methylglutaryl coenzyme A reductase inhibitor, in the control of severe FH in a male pediatric population and to evaluate the d

APA, Harvard, Vancouver, ISO, and other styles

14

Huang, Xiaoming, Ning Liang, Fuming Zhang, Wanjun Lin, and Wenzhe Ma. "Lovastatin-Induced Mitochondrial Oxidative Stress Leads to the Release of mtDNA to Promote Apoptosis by Activating cGAS-STING Pathway in Human Colorectal Cancer Cells." Antioxidants 13, no. 6 (2024): 679. http://dx.doi.org/10.3390/antiox13060679.

Full text

Abstract:

Statins are 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductase inhibitors widely used in the treatment of hyperlipidemia. The inhibition of HMG-CoA reductase in the mevalonate pathway leads to the suppression of cell proliferation and induction of apoptosis. The cyclic GMP-AMP synthase (cGAS) stimulator of the interferon genes (STING) signaling pathway has been suggested to not only facilitate inflammatory responses and the production of type I interferons (IFN), but also activate other cellular processes, such as apoptosis. It has not been studied, however, whether cGAS-STING activatio

APA, Harvard, Vancouver, ISO, and other styles

15

Deanin, G. G., J. L. Cutts, J. R. Pfeiffer, and J. M. Oliver. "Role of isoprenoid metabolism in IgE receptor-mediated signal transduction." Journal of Immunology 146, no. 10 (1991): 3528–35. http://dx.doi.org/10.4049/jimmunol.146.10.3528.

Full text

Abstract:

Abstract In the 2H3 subline of rat basophilic leukemia cells (RBL-2H3), IgE receptor cross-linking stimulates a signal transduction pathway that leads to the secretion of histamine, serotonin, and other inflammatory mediators; the assembly of F-actin; and the transformation of the cell surface from a microvillous to a lamellar or ruffled architecture. We report here that 20 h incubation of RBL-2H3 cells with 10 microM lovastatin, an inhibitor of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase (HMG CoA reductase), inhibits both the secretory and morphologic responses to IgE receptor cross-link

APA, Harvard, Vancouver, ISO, and other styles

16

MONTALVETTI, Andrea, Javier PE±A-DÍAZ, Ramón HURTADO, Luis Miguel RUIZ-PÉREZ, and Dolores GONZÁLEZ-PACANOWSKA. "Characterization and regulation of Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase." Biochemical Journal 349, no. 1 (2000): 27–34. http://dx.doi.org/10.1042/bj3490027.

Full text

Abstract:

In eukaryotes the enzyme 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) reductase catalyses the synthesis of mevalonic acid, a common precursor to all isoprenoid compounds. Here we report the isolation and overexpression of the gene coding for HMG-CoA reductase from Leishmania major. The protein from Leishmania lacks the membrane domain characteristic of eukaryotic cells but exhibits sequence similarity with eukaryotic reductases. Highly purified protein was achieved by ammonium sulphate precipitation followed by chromatography on hydroxyapatite. Kinetic parameters were determined for the protozoan

APA, Harvard, Vancouver, ISO, and other styles

17

Ginger, Michael L., Michael L. Chance, Ian H. Sadler, and L. John Goad. "The Biosynthetic Incorporation of the Intact Leucine Skeleton into Sterol by the TrypanosomatidLeishmania mexicana." Journal of Biological Chemistry 276, no. 15 (2001): 11674–82. http://dx.doi.org/10.1074/jbc.m006850200.

Full text

Abstract:

The amino acid leucine is efficiently used by the trypanosomatidLeishmania mexicanafor sterol biosynthesis. The incubation of [2-13C]leucine withL. mexicanapromastigotes in the presence of ketoconazole gave 14α-methylergosta-8,24(241)-3β-ol as the major sterol, which was shown by mass spectrometry to contain up to six atoms of13C per molecule.13C NMR analysis of the 14α-methylergosta-8,24(241)-3β-ol revealed that it was labeled in only six positions: C-2, C-6, C-11, C-12, C-16, and C-23. This established that the leucine skeleton is incorporated intact into the isoprenoid pathway leading to st

APA, Harvard, Vancouver, ISO, and other styles

18

Guan, Xin, Lei Yin, Yan Yang, Xiang-Jun Meng, De-Li Wang, and Yan-Tong Sun. "Quantitation of lovastatin and its hydroxy acid in human plasma by high-performance liquid chromatography-tandem mass spectrometry." Journal of Liquid Chromatography & Related Technologies 41, no. 10 (2018): 668–75. http://dx.doi.org/10.1080/10826076.2018.1508473.

Full text

APA, Harvard, Vancouver, ISO, and other styles

19

Chamilos, Georgios, Russell E. Lewis, and Dimitrios P. Kontoyiannis. "Lovastatin Has Significant Activity against Zygomycetes and Interacts Synergistically with Voriconazole." Antimicrobial Agents and Chemotherapy 50, no. 1 (2006): 96–103. http://dx.doi.org/10.1128/aac.50.1.96-103.2006.

Full text

Abstract:

ABSTRACT Zygomycetes are emerging opportunistic molds resistant to most conventional antifungals. We evaluated the in vitro activity of lovastatin (LOV), a 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor, against seven clinical isolates of Zygomycetes by using standard microdilution methods in three different media, disk diffusion testing, and viability dye staining. To further study the in vivo efficacy of LOV against zygomycetes, we developed a Drosophila melanogaster model of zygomycosis. In different experiments, groups of Toll-deficient (Tl) flies fed LOV-containing food were su

APA, Harvard, Vancouver, ISO, and other styles

20

Klingelhöfer, Ines, and Gertrud E. Morlock. "Lovastatin in lactone and hydroxy acid forms and citrinin in red yeast rice powders analyzed by HPTLC-UV/FLD." Analytical and Bioanalytical Chemistry 411, no. 25 (2019): 6655–65. http://dx.doi.org/10.1007/s00216-019-02039-y.

Full text

APA, Harvard, Vancouver, ISO, and other styles

21

Patil, R. H., M. P. Patil та V. L. Maheshwari. "Rapid Chromatographic Determination and Structural Confirmation of β-Hydroxy Acid Form of Lovastatin in the Fermentation Broth of Aspergillus Terreus PM03". Pharmaceutical Chemistry Journal 49, № 6 (2015): 419–24. http://dx.doi.org/10.1007/s11094-015-1298-5.

Full text

APA, Harvard, Vancouver, ISO, and other styles

22

Wu, Yunhui, Jamie Zhao, Jack Henion, Walter A. Korfmacher, Amelia P. Lapiguera, and Chin-Chung Lin. "Microsample Determination of Lovastatin and its Hydroxy Acid Metabolite in Mouse and Rat Plasma by Liquid Chromatography/Ionspray Tandem Mass Spectrometry." Journal of Mass Spectrometry 32, no. 4 (1997): 379–87. http://dx.doi.org/10.1002/(sici)1096-9888(199704)32:4<379::aid-jms461>3.0.co;2-9.

Full text

APA, Harvard, Vancouver, ISO, and other styles

23

Bok, Song-Hae, Sun-Young Park, Yong Bok Park, et al. "Quercetin Dihydrate and Gallate Supplements Lower Plasma and Hepatic Lipids and Change Activities of Hepatic Antioxidant Enzymes in High Cholesterol-Fed Rats." International Journal for Vitamin and Nutrition Research 72, no. 3 (2002): 161–69. http://dx.doi.org/10.1024/0300-9831.72.3.161.

Full text

Abstract:

This study was designed to test the lipid-lowering and antioxidant activity of two bioflavonoids, quercetin dihydrate and gallate. Four groups of rats were given a semisynthetic diet containing 10 g cholesterol/kg for six weeks. The control group received only a high-cholesterol diet, whereas the other three groups received a diet including 1 g lovastatin, 1 g quercetin dihydrate, or 1 g gallate/kg. The quercetin dihydrate and gallate supplements both significantly lowered the plasma lipid and hepatic cholesterol levels compared to those of the control. The hepatic 3-hydroxy-3-methylglutaryl-C

APA, Harvard, Vancouver, ISO, and other styles

24

Ngoc Chuong, Nai, Thai Long Tran, Thanh Thi Ta, Son Van Pham, Hung Viet Tran, and Tuan Duc Nguyen. "Development and validation of simultaneous assay of simvastatin, beta-hydroxy simvastatin as metabolite in human plasma using liquid chromatography-tandem mass spectrometry." MedPharmRes 6, no. 2 (2021): 9–17. http://dx.doi.org/10.32895/ump.mpr.6.2.2.

Full text

Abstract:

Introduction: Several generic products containing simvastatin are circulating on the Vietnamese market at a more inexpensive price than that of a brand-name one. These formulations, however, have not been assessed for in vivo bioequivalence to the reference product. After oral administration, simvastatin (SIM) is extensively converted into an active metabolite, beta-hydroxy simvastatin acid (SIM-A) and a very low concentration of simvastatin can be found in plasma. Therefore, a method for quantification of simvastatin and its metabolite needs to be developed with a high specificity and sensiti

APA, Harvard, Vancouver, ISO, and other styles

25

Goto, Tsuyoshi, Hiroyuki Nagai, Kahori Egawa та ін. "Farnesyl pyrophosphate regulates adipocyte functions as an endogenous PPARγ agonist". Biochemical Journal 438, № 1 (2011): 111–19. http://dx.doi.org/10.1042/bj20101939.

Full text

Abstract:

The cholesterol biosynthetic pathway produces not only sterols but also non-sterol mevalonate metabolites involved in isoprenoid synthesis. Mevalonate metabolites affect transcriptional and post-transcriptional events that in turn affect various biological processes including energy metabolism. In the present study, we examine whether mevalonate metabolites activate PPARγ (peroxisome-proliferator-activated receptor γ), a ligand-dependent transcription factor playing a central role in adipocyte differentiation. In the luciferase reporter assay using both GAL4 chimaera and full-length PPARγ syst

APA, Harvard, Vancouver, ISO, and other styles

26

Robinson, G. W., Y. H. Tsay, B. K. Kienzle, C. A. Smith-Monroy, and R. W. Bishop. "Conservation between human and fungal squalene synthetases: similarities in structure, function, and regulation." Molecular and Cellular Biology 13, no. 5 (1993): 2706–17. http://dx.doi.org/10.1128/mcb.13.5.2706-2717.1993.

Full text

Abstract:

Squalene synthetase (farnesyl diphosphate:farnesyl diphosphate farnesyltransferase; EC 2.5.1.21) is thought to represent a major control point of isoprene and sterol biosynthesis in eukaryotes. We demonstrate structural and functional conservation between the enzymes from humans, a budding yeast (Saccharomyces cerevisiae), and a fission yeast (Schizosaccharomyces pombe). The amino acid sequences of the human and S. pombe proteins deduced from cloned cDNAs were compared to those of the known S. cerevisiae protein. All are predicted to encode C-terminal membrane-spanning proteins of approximatel

APA, Harvard, Vancouver, ISO, and other styles

27

Robinson, G. W., Y. H. Tsay, B. K. Kienzle, C. A. Smith-Monroy, and R. W. Bishop. "Conservation between human and fungal squalene synthetases: similarities in structure, function, and regulation." Molecular and Cellular Biology 13, no. 5 (1993): 2706–17. http://dx.doi.org/10.1128/mcb.13.5.2706.

Full text

Abstract:

Squalene synthetase (farnesyl diphosphate:farnesyl diphosphate farnesyltransferase; EC 2.5.1.21) is thought to represent a major control point of isoprene and sterol biosynthesis in eukaryotes. We demonstrate structural and functional conservation between the enzymes from humans, a budding yeast (Saccharomyces cerevisiae), and a fission yeast (Schizosaccharomyces pombe). The amino acid sequences of the human and S. pombe proteins deduced from cloned cDNAs were compared to those of the known S. cerevisiae protein. All are predicted to encode C-terminal membrane-spanning proteins of approximatel

APA, Harvard, Vancouver, ISO, and other styles

28

Wolozin, B. "Cholesterol and Alzheimer's disease." Biochemical Society Transactions 30, no. 4 (2002): 525–29. http://dx.doi.org/10.1042/bst0300525.

Full text

Abstract:

Accumulation of a 40–42-amino acid peptide, termed amyloid-β peptide (Aβ), is associated with Alzheimer's disease (AD), and identifying medicines that inhibit Aβ could help patients with AD. Recent evidence suggests that a class of medicines that lower cholesterol by blocking the enzyme 3-hydroxy-3-methylglutaryl-CoA reductase (HMG-CoA reductase), termed statins, can inhibit Aβ production. Increasing evidence suggests that the enzymes that generate Aβ function best in a high-cholesterol environment, which might explain why reducing cholesterol would inhibit Aβ production. Studies using both ne

APA, Harvard, Vancouver, ISO, and other styles

29

Kała, Katarzyna, Wojciech Pająk, Katarzyna Sułkowska-Ziaja, et al. "Hypsizygus marmoreus as a Source of Indole Compounds and Other Bioactive Substances with Health-Promoting Activities." Molecules 27, no. 24 (2022): 8917. http://dx.doi.org/10.3390/molecules27248917.

Full text

Abstract:

Hypsizygus marmoreus is an edible medicinal mushroom species with a high dietary value. In this study, the fruiting bodies of commercial and self-cultivated crops and mycelium from in vitro H. marmoreus cultures (both white and brown varieties) were evaluated. This study aimed to analyze the presence of indole compounds and other biologically active substances and determine the effect that the addition of zinc and magnesium ions to the culture medium has on the content of the tested compounds in mycelial cultures. The content of indole compounds and other organic compounds was determined using

APA, Harvard, Vancouver, ISO, and other styles

30

Beltrán, D., M. D. Frutos-Lisón, J. C. Espín та R. García-Villalba. "Re-examining the role of the gut microbiota in the conversion of the lipid-lowering statin monacolin K (lovastatin) into its active β-hydroxy acid metabolite". Food & Function 10, № 4 (2019): 1787–91. http://dx.doi.org/10.1039/c8fo02594k.

Full text

APA, Harvard, Vancouver, ISO, and other styles

31

Jansen, Gerrit, Marjon Al, Yehuda G. Assaraf, et al. "Statins markedly potentiate aminopeptidase inhibitor activity against (drug-resistant) human acute myeloid leukemia cells." Cancer Drug Resistance 6, no. 2 (2023): 430–46. http://dx.doi.org/10.20517/cdr.2023.20.

Full text

Abstract:

Aim: This study aimed to decipher the molecular mechanism underlying the synergistic effect of inhibitors of the mevalonate-cholesterol pathway (i.e., statins) and aminopeptidase inhibitors (APis) on APi-sensitive and -resistant acute myeloid leukemia (AML) cells. Methods: U937 cells and their sublines with low and high levels of acquired resistance to (6S)-[(R)-2-((S)-Hydroxy-hydroxycarbamoyl-methoxy-methyl)-4-methyl-pentanoylamino]-3,3 dimethyl-butyric acid cyclopentyl ester (CHR2863), an APi prodrug, served as main AML cell line models. Drug combination effects were assessed with CHR2863 an

APA, Harvard, Vancouver, ISO, and other styles

32

Vanhee, Celine, Bram Jacobs, Michael Canfyn, et al. "Quality Control and Safety Assessment of Online-Purchased Food Supplements Containing Red Yeast Rice (RYR)." Foods 13, no. 12 (2024): 1919. http://dx.doi.org/10.3390/foods13121919.

Full text

Abstract:

Dietary supplements containing red yeast rice (RYR), a fermentation product of the fungus Monascus purpureus grown on white rice, remain popular in Europe as proclaimed cholesterol-lowering aids. The cholesterol-lowering effects are due to the occurrence of monacolin K, which is often present as a mixture of monacolin K lactone (MK) and as monacolin K hydroxy acid (MKA). MK is structurally similar to the cholesterol-lowering medicine lovastatin. Recently, due to safety concerns linked to the use of statins, the European Commission prohibited RYR supplements with a maximum serving exceeding 3 m

APA, Harvard, Vancouver, ISO, and other styles

33

Mircia, Eleonora, Gabriel Hancu, Aura Rusu, Adriana Cazacu, Teodora Balaci, and Ruxandra Soare. "Determination of HMG-CoA reductase inhibitors by micellar electrokinetic chromatography." Acta Medica Marisiensis 62, no. 2 (2016): 187–91. http://dx.doi.org/10.1515/amma-2016-0006.

Full text

Abstract:

AbstractObjective: In this study we report the development of a simple, rapid and efficient capillary electrophoresis method for the simultaneous determination of atorvastatin, fluvastatin, lovastatin and simvastin.Methods: Capillary zone electrophoresis proved to be efficient for the simultaneous separation of atorvastatin and fluvastatin, but could not resolve the determination of lovastatin and simvastatin. The simultaneous separation of all four statins was achieved by applying a micellar electrokinetic chromatographic method, after transforming lovastatin and simvastatin in β-hydroxyl aci

APA, Harvard, Vancouver, ISO, and other styles

34

Batta, Ashok K., Gerald Salen та G. Stephen Tint. "Hydrophilic 7β-hydroxy bile acids, lovastatin, and cholestyramine are ineffective in the treatment of cerebrotendinous xanthomatosis". Metabolism 53, № 5 (2004): 556–62. http://dx.doi.org/10.1016/j.metabol.2003.12.003.

Full text

APA, Harvard, Vancouver, ISO, and other styles

35

Nguyen, Lien B., Sarah Shefer, Gerald Salen, et al. "Regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity in the rat ileum: Effects of bile acids and lovastatin." Metabolism 43, no. 11 (1994): 1446–50. http://dx.doi.org/10.1016/0026-0495(94)90043-4.

Full text

APA, Harvard, Vancouver, ISO, and other styles

36

Honda, Akira, Gerald Salen, Lien B. Nguyen, et al. "Regulation of early cholesterol biosynthesis in rat liver: Effects of sterols, bile acids, lovastatin, and BM 15.766 on 3-hydroxy-3-methylglutaryl coenzyme A synthase and acetoacetyl coenzyme A thiolase activities." Hepatology 27, no. 1 (1998): 154–59. http://dx.doi.org/10.1002/hep.510270124.

Full text

APA, Harvard, Vancouver, ISO, and other styles

37

Divadari, Hareesh, та Vijay Srinivas Pothula. "Development and Validation of LC-MS/MS Method for the Estimation of Lovastatin and its Metabolite (β-Hydroxy Acid) in Pharmaceutical Dosage Form". International Journal of Pharmaceutical Quality Assurance 8, № 1 (2017). http://dx.doi.org/10.25258/ijpqa.v8i1.8436.

Full text

Abstract:

The objective of this study was to validate a simple, specific, accurate and precise Liquid - Liquid extraction high performance liquid chromatographic method with Tandem Mass Spectrometry-Thermo Scientific TSQ Quantum Ultra method for the determination of Lovastatin and Lovastatin acid in human plasma using Atorvastatin as Internal Standard (IS). The precision and accuracy data have to fulfill the requirements for quantification of the analytes in biological matrices to generate data for bioequivalence, bioavailability investigations. A Luna C18, 5µmcolumn having 4.6 x 150 mm internal diamete

APA, Harvard, Vancouver, ISO, and other styles

38

Elfakhani, Manal, Sophie Yount, and Huanbiao Mo. "Geranylgeraniol Suppresses the Expression of Adipogenic Genes and the Differentiation of Murine 3T3‐F442A and 3T3‐L1 Preadipocytes." FASEB Journal 31, S1 (2017). http://dx.doi.org/10.1096/fasebj.31.1_supplement.lb394.

Full text

Abstract:

Fundamental to the pathology of obesity is the hypertrophy and hyperplasia of adipocytes. Lipid accumulation in differentiated adipocytes is part of the adipocyte lifecycle that eventually leads to recruitment of macrophages and inflammation. We have previously shown that lovastatin, a competitive inhibitor of 3‐hydroxy‐3‐methylglutaryl coenzyme A (HMG CoA) reductase, suppresses the differentiation of murine 3T3‐F442A adipocytes via mevalonate deprivation. Tocotrienols, down‐regulators of HMG CoA reductase, inhibit adipocyte differentiation via suppression of peroxisome proliferator‐activated

APA, Harvard, Vancouver, ISO, and other styles

39

Divadari, Hareesh. "DEVELOPMENT AND VALIDATION OF LC-MS/MS METHOD FOR THE ESTIMATION OF LOVASTATIN AND ITS METABOLITE (β-HYDROXY ACID) IN PHARMACEUTICAL DOSAGE FORM". World Journal of Pharmacy and Pharmaceutical Sciences, 1 квітня 2017, 1452–71. http://dx.doi.org/10.20959/wjpps20174-8929.

Full text

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!