To see the other types of publications on this topic, follow the link: Low-cholesterol diet.
Journal articles on the topic 'Low-cholesterol diet'
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the top 50 journal articles for your research on the topic 'Low-cholesterol diet.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.
1
BASCHETTI, R. "The low fat/low cholesterol diet." European Heart Journal 18, no. 9 (September 1, 1997): 1514–15. http://dx.doi.org/10.1093/oxfordjournals.eurheartj.a015481.
Full text
2
Giugliano, Dario, and Katherine Esposito. "Statins, Diet, and Low Cholesterol." JAMA 295, no. 21 (June 7, 2006): 2479. http://dx.doi.org/10.1001/jama.295.21.2479-a.
Full text
3
Arora, Rohit, and Saravanan Balamuthusamy. "Statins, Diet, and Low Cholesterol." JAMA 295, no. 21 (June 7, 2006): 2479. http://dx.doi.org/10.1001/jama.295.21.2479-b.
Full text
4
Cannon, Christopher P. "Statins, Diet, and Low Cholesterol—Reply." JAMA 295, no. 21 (June 7, 2006): 2479. http://dx.doi.org/10.1001/jama.295.21.2479-c.
Full text
5
CORR, L. A., and M. F. OLIVER. "The low fat/low cholesterol diet is ineffective." European Heart Journal 18, no. 1 (January 1, 1997): 18–22. http://dx.doi.org/10.1093/oxfordjournals.eurheartj.a015111.
Full text
6
Morgan, John, Kirsten Horton, Dana Reese, Christina Carey, Kalen Walker, and David Capuzzi. "Effects of Walnut Consumption as Part of a Low-Fat, Low-Cholesterol Diet on Serum Cardiovascular Risk Factors." International Journal for Vitamin and Nutrition Research 72, no. 5 (October 1, 2002): 341–47. http://dx.doi.org/10.1024/0300-9831.72.5.341.
Full textAbstract:
Serum components, such as lipoproteins, coagulation factors (factor VII, tissue plasminogen activator (tPA), plasminogen activator inhibitor-1 (PAI-1), fibrinogen), and homocysteine have been associated with cardiovascular disease. Dietary intervention with a low-fat, low-cholesterol diet has favorably influenced cardiovascular disease and certain food, specifically the consumption of nuts, has been associated with reduced cardiovascular risks. The effects of walnuts, as part of a low-fat, low-cholesterol diet, on serum cardiovascular risk factors were determined. Sixty-seven (67) outpatients with borderline high total cholesterol following a low-fat, low-cholesterol diet for six weeks before being randomly assigned to continue the diet or have 64 grams/day of walnuts in conjunction with the diet. After six weeks, the patients’ diets were switched. Therefore, all patients consumed 64 grams/day of walnuts for six weeks during part of the trial as part of a low-fat, low cholesterol diet. Serum lipids demonstrated a significant reduction in triacyglycerols and favorable trend with decreases in total cholesterol, low-density lipoprotein (LDL) cholesterol, and a slight increase in high-density lipoprotein (HDL) cholesterol. No statistical effects on homocysteine or the coagulation factors were observed. However, there was a slight favorable trend for tPA and PAI-1. This study demonstrated that walnuts, when consumed as part of a low fat, low-cholesterol diet, have a beneficial effect on serum cardiovascular risk factors. However, these changes may not explain all of the beneficial effects that walnut consumption has on cardiovascular disease.
7
Lacombe, Christiane R., Geneviève R. Corraze, Maryse M. Nibbelink, Danièle Boulze, Philippe Douste-Blazy, and Rita Camare. "Effects of a low-energy diet associated with egg supplementation on plasma cholesterol and lipoprotein levels in normal subjects: results of a cross-over study." British Journal of Nutrition 56, no. 3 (November 1986): 561–75. http://dx.doi.org/10.1079/bjn19860137.
Full textAbstract:
1. The influence of a low-energy diet when associated with high-cholesterol intake was investigated in seventeen normal men during an 8-week cross-over study. The subjects were given a daily supplement of two whole eggs and two egg yolks (approximately 1 g cholesterol) either with their usual diet for 4 weeks or with a low-energy diet for 4 weeks. Each subject took part randomly in both dietary periods.2. During the first part of the study, no changes occurred in the plasma cholesterol of the subjects with egg supplementation of the usual diet.3. In contrast, the low-energy diet and associated weight loss markedly decreased the tolerance to high- cholesterol intake resulting in increased plasma cholesterol. The mean rise was 22.7% but with wide individual variations in the response. This was almost completely normalized when the subjects returned to their usual energy intake indicating the involvement of weight reduction in the increase observed.4. Changes in low-density-lipoprotein (LDL) cholesterol were parallel to those of total plasma cholesterol with an increase following the low-energy diet and normalization after body-weight recovery.5. The opposite effect was shown with the low-energy diet after previous adaptation to the consumption of four eggs per day. This dietary regimen resulted in a decrease in plasma cholesterol although it was not significant. Moreover, the lipoprotein profile was improved with a decrease in very-low-density-lipoprotein (VLDL) cholesterol and an increase in high-density-lipoprotein (HDL) cholesterol.6. High-cholesterol intake induced significant changes in lipoprotein composition whatever the energy ration. LDL and HDL were enriched in cholesterol esters as early as the 1st month of egg supplementation of the diet.7. Taken together, the results emphasize the possible adverse effect of slimming diets when associated with high-cholesterol intake. The existence of ‘high-responders’ to these dietary conditions calls for special attention to be paid to the cholesterol content of restricted diets.
8
DUNN, A. V. "Incorporating soy protein into a low-fat, low-cholesterol diet." Cleveland Clinic Journal of Medicine 67, no. 10 (October 1, 2000): 767–71. http://dx.doi.org/10.3949/ccjm.67.10.767.
Full text
9
Utzschneider, Kristina M., Jennifer L. Bayer-Carter, Matthew D. Arbuckle, Jaime M. Tidwell, Todd L. Richards, and Suzanne Craft. "Beneficial effect of a weight-stable, low-fat/low-saturated fat/low-glycaemic index diet to reduce liver fat in older subjects." British Journal of Nutrition 109, no. 6 (July 31, 2012): 1096–104. http://dx.doi.org/10.1017/s0007114512002966.
Full textAbstract:
Non-alcoholic fatty liver disease is associated with insulin resistance and dyslipidaemia and can progress to steatohepatitis and cirrhosis. We sought to determine whether dietary fat and saturated fat content alter liver fat in the absence of weight change in an older population. Liver fat was quantified by magnetic resonance spectroscopy before and after 4 weeks on an isoenergetic low-fat/low-saturated fat/low-glycaemic index (LGI) (LSAT: 23 % fat/7 % saturated fat/GI < 55) or a high-fat/high-saturated fat/high-GI (HSAT: 43 % fat/24 % saturated fat/GI>70) diet in older subjects. In the present study, twenty subjects (seven males/thirteen females; age 69·3 (sem1·6) years, BMI 26·9 (sem0·8) kg/m2) were randomised to the LSAT diet and fifteen subjects (six males/nine females; age 68·6 (sem1·8) years, BMI 28·1 (sem0·9) kg/m2) to the HSAT diet. Weight remained stable. Liver fat decreased significantly on the LSAT diet (median 2·2 (interquartile range (IQR) 3·1) to 1·7 (IQR 1·8) %,P= 0·002) but did not change on the HSAT diet (median 1·2 (IQR 4·1) to 1·6 (IQR 3·9) %). The LSAT diet lowered fasting glucose and total cholesterol, HDL-cholesterol and LDL-cholesterol and raised TAG (P< 0·05), while the HSAT diet had no effect on glucose or HDL-cholesterol but increased total cholesterol and LDL-cholesterol (P< 0·05). Fasting insulin and homeostasis model of insulin resistance did not change significantly on either diet, but the Matsuda index of insulin sensitivity improved on the LSAT diet (P< 0·05). Assignment to the LSATv.HSAT diet was a predictor of changes in lipid parameters but not liver fat. We conclude that diet composition may be an important factor in the accumulation of liver fat, with a low-fat/low-saturated fat/LGI diet being beneficial.
10
Chan, Jeannie, Rampratap S. Kushwaha, Jane F. VandeBerg, Jelica Gluhak-Heinrich, and John L. VandeBerg. "Differential Expression of Intestinal Genes in Opossums with High and Low Responses to Dietary Cholesterol." Journal of Nutrition and Metabolism 2010 (2010): 1–8. http://dx.doi.org/10.1155/2010/415075.
Full textAbstract:
High and low responding opossums (Monodelphis domestica) differ in their plasma very low density lipoprotein and low density lipoprotein (VLDL+LDL) cholesterol concentrations when they consume a high cholesterol diet, which is due in part to absorption of a higher percentage of dietary cholesterol in high responders. We compared the expression of a set of genes that influence cholesterol absorption in high and low responders fed a basal or a high cholesterol and low fat (HCLF) diet. Up-regulation of theABCG5,ABCG8, andIBABPgenes by the HCLF diet in high and low responders may reduce cholesterol absorption to maintain cholesterol homeostasis. Differences in expression of the phospholipase genes (PLA2andPLB) and phospholipase activity were associated with differences in cholesterol absorption when opossums were fed cholesterol-enriched diets. HigherPLA2andPLBmRNA levels and higher phospholipase activity may increase cholesterol absorption in high responders by enhancing the release of cholesterol from bile salt micelles for uptake by intestinal cells.
11
de Rose, Nicole M., Michiel L. Bots, Els Siebelink, Evert Schouten, and Martijin B. Katan. "Flow-mediated vasodilation is not impaired when HDL-cholesterol is lowered by substituting carbohydrates for monounsaturated fat." British Journal of Nutrition 86, no. 2 (August 2001): 181–88. http://dx.doi.org/10.1079/bjn2001365.
Full textAbstract:
Low-fat diets, in which carbohydrates replace some of the fat, decrease serum cholesterol. This decrease is due to decreases in LDL-cholesterol but in part to possibly harmful decreases in HDL-cholesterol. High-oil diets, in which oils rich in monounsaturated fat replace some of the saturated fat, decrease serum cholesterol mainly through LDL-cholesterol. We used these two diets to investigate whether a change in HDL-cholesterol would change flow-mediated vasodilation, a marker of endothelial function. We fed thirty-two healthy volunteers two controlled diets in a 2×3·5 weeks' randomised cross-over design to eliminate variation in changes due to differences between subjects. The low-fat diet contained 59·7 % energy (en%) as carbohydrates and 25·7 en% as fat (7·8 en% as monounsaturates); the oil-rich diet contained 37·8 en% as carbohydrates and 44·4 en% as fat (19·3 en% as monounsaturates). Average (SD) SERUM HDL-CHOLESTEROL AFTER THE LOW-FAT DIET WAS 0·21 (sd 0·12) mmol/l (8·1 mg/dl) lower than after the oil-rich diet. Serum triacylglycerols were 0·22 (sd 0·28) mmol/l (19·5 mg/dl) higher after the low-fat diet than after the oil-rich diet. Serum LDL and homocysteine concentrations remained stable. Flow-mediated vasodilation was 4·8 (SD 2·9) after the low-fat diet and 4·1 (SD 2·7) after the oil-rich diet (difference 0·7 %; 95 % CI -0·6, 1·9). Thus, although the low-fat diet produced a lower HDL-cholesterol than the high-oil diet, flow-mediated vasodilation, an early marker of cardiovascular disease, was not impaired.
12
Bydlowski, S. P., V. L. G. Stivaletti, and C. R. Douglas. "Biochemical observations on rat aorta: interaction of dietary protein and cholesterol." British Journal of Nutrition 55, no. 2 (March 1986): 295–304. http://dx.doi.org/10.1079/bjn19860037.
Full textAbstract:
1. The effect of cholesterol feeding during and after a period of protein malnutrition lasting 4 weeks was examined in the rat. Indices measured were plasma total cholesterol, triglycerides and protein levels, and aorta total cholesterol, triglycerides, hexosamine and hydroxyproline concentrations.2. In both plasma and aorta, total cholesterol and triglycerides levels were higher in the low-protein diet group than in the standard-protein diet group, when cholesterol was supplied in both diets.3. During the malnutrition period, cholesterol feeding led to a greater decrease in plasma protein than that promoted by the low-protein diet without cholesterol, while aorta hexosamine levels decreased to a lesser extent.4. Cholesterol feeding with a standard-protein diet promoted a slight and temporary increase in aorta hydroxyproline levels, while a decrease in aorta hexosamine concentration was observed. Cholesterol feeding with the low-protein diet, on the other hand, also promoted a decrease in aorta hexosamine levels but to a lesser extent.5. During the recovery period, cholesterol feeding impaired the return of plasma protein, aorta hexosamine and lipid levels to that of the control values.6. These findings demonstrate that cholesterol feeding promotes different changes in aorta and plasma, depending on whether or not protein is supplied by the diet in adequate amounts. This point could be important in relation to the development of atherosclerosis during recovery from a period of malnutrition.
13
Vigne, Jean Louis, Denis Lairon, Patrick Borel, Henri Portugal, Anne-Marie Pauli, Jacques Christian Hauton, and Huguette Lafont. "Effect of pectin, wheat bran and cellulose on serum lipids and lipoproteins in rats fed on a low- or high-fat diet." British Journal of Nutrition 58, no. 3 (November 1987): 405–13. http://dx.doi.org/10.1079/bjn19870109.
Full textAbstract:
1. Four groups of adult male Sprague–Dawley rats were fed for 6 weeks on a diet with a low-fat content (50 g/kg) and another four groups were given a diet rich in fat (250 g/kg) and cholesterol (12 g/kg). In both cases, the basal diets were either fibre-depleted or supplemented with cellulose (60 g/kg), wheat bran (100 g/kg) or low-methoxyl pectin (100 g/kg).2. Low-methoxyl pectin displayed the most hypocholesterolaemic effect and decreased the cholesterol content of the very-low-density lipoproteins (VLDL) and low-density lipoproteins (LDL), when the low-fat diet was given. When rats were fed on the high-fat diet, pectin no longer had a hypocholesterolaemic effect but still decreased the VLDL-cholesterol content. Pectin lowered serum triglyceride and VLDL-trigylceride levels only when the low-fat diet was given.3. Wheat bran exerted no hypocholesterolaemic effect in rats fed on the low- and high-fat diets, but decreased the cholesterol content of VLDL and lowered serum triglycerides and VLDL-tryglycerides when the high-fat diet was given.4. Purified cellulose had no significant effect on plasma lipids.5. As shown by multivariance analysis, low-methoxyl pectin and wheat bran both beneficially modified the serum triglyceride and cholesterol variables except VLDL-triglycerides. However, the magnitude of the effect of each individual type of fibre was dependent on the fat and cholesterol content of the diet, suggesting the existence of different mechanisms of action.
14
Nissinen, Markku J., Helena Gylling, and Tatu A. Miettinen. "Responses of surrogate markers of cholesterol absorption and synthesis to changes in cholesterol metabolism during various amounts of fat and cholesterol feeding among healthy men." British Journal of Nutrition 99, no. 2 (February 2008): 370–78. http://dx.doi.org/10.1017/s0007114507811998.
Full textAbstract:
Serum ratios to cholesterol of lathosterol, and of cholestanol, campesterol and sitosterol measure respective relative cholesterol synthesis and absorption, but their clinical applicability is not known in evaluation of cholesterol metabolism under different dietary conditions. We compared relative synthesis and absorption of cholesterol to the respective absolute ones in healthy male volunteers (n29) on four subsequent diets: baseline home (HD), low-cholesterol low-fat (LCLF), high-cholesterol low-fat (HCLF) and low-cholesterol high-fat (LCHF). Serum lipids, lipoproteins, sterols, fractional cholesterol absorption and sterol synthesis were examined. HCLF and LCHF decreased fractional cholesterol absorption by approximately 23–27 % from baseline HD (P < 0·05) and increased the levels of total and LDL-cholesterol in serum from LCLF by approximately 9–14 % (P < 0·05). On HCLF, bile acid synthesis was high (P < 0·05 for each), and absolute cholesterol synthesis tended to be higher than on HD and LCHF (NS). Relative synthesis was positively associated with absolute cholesterol synthesis, but inversely with relative absorption during each diet (P < 0·05). The relative absorption markers were interrelated in each diet, and were also associated with fractional absorption of cholesterol in each diet but HD. In conclusion, relative markers of cholesterol absorption and synthesis reflect changes in cholesterol metabolism despite the amount of dietary fat and cholesterol consumed, but their validity with this respect is strengthened by controlled diets in metabolic studies. Additions of cholesterol and fat to a diet low in fat and cholesterol cause practically equal changes in the serum lipid profiles, whereas synthesis of cholesterol (NS) and bile acids (P < 0·05) were higher with the high-cholesterol feeding.
15
Vergara, Monica, Michelle E. Hauser, Lucia Aronica, Joseph Rigdon, Priya Fielding-Singh, Cynthia W. Shih, and Christopher D. Gardner. "Associations of Changes in Blood Lipid Concentrations with Changes in Dietary Cholesterol Intake in the Context of a Healthy Low-Carbohydrate Weight Loss Diet: A Secondary Analysis of the DIETFITS Trial." Nutrients 13, no. 6 (June 4, 2021): 1935. http://dx.doi.org/10.3390/nu13061935.
Full textAbstract:
In 2015, the Dietary Guidelines for Americans (DGA) eliminated the historical upper limit of 300 mg of dietary cholesterol/day and shifted to a more general recommendation that cholesterol intake should be limited. The primary aim of this secondary analysis of the Diet Intervention Examining the Factors Interacting With Treatment Success (DIETFITS) weight loss diet trial was to evaluate the associations between 12-month changes in dietary cholesterol intake (mg/day) and changes in plasma lipids, particularly low-density lipoprotein (LDL) cholesterol for those following a healthy low-carbohydrate (HLC) diet. Secondary aims included examining high-density lipoprotein (HDL) cholesterol and triglycerides and changes in refined grains and added sugars. The DIETFITS trial randomized 609 healthy adults aged 18–50 years with body mass indices of 28–40 kg/m2 to an HLC or healthy low-fat (HLF) diet for 12 months. Linear regressions examined the association between 12-month change in dietary cholesterol intake and plasma lipids in 208 HLC participants with complete diet and lipid data, adjusting for potential confounding variables. Baseline dietary cholesterol intake was 322 ± 173 (mean ± SD). At 12 months, participants consumed an average of 460 ± 227 mg/day of dietary cholesterol; 76% consumed over the previously recommended limit of 300 mg/day. Twelve-month changes in cholesterol intake were not significantly associated with 12-month changes in LDL-C, HDL-C, or triglycerides. Diet recall data suggested participants’ increase in dietary cholesterol was partly due to replacing refined grains and sugars with eggs. An increase in daily dietary cholesterol intake to levels substantially above the previous 300 mg upper limit was not associated with a negative impact on lipid profiles in the setting of a healthy, low-carbohydrate weight loss diet.
16
Zou, Xian-Guo, Yu-Hua Huang, Hong-Yan Li, Tong-Cheng Xu, Ya-Wei Fan, Jing Li, and Ze-Yuan Deng. "Effects of Chinese Dietary Pattern of Fat Content, n-6/n-3 Polyunsaturated Fatty Acid Ratio, and Cholesterol Content on Lipid Profile in Rats." BioMed Research International 2018 (2018): 1–13. http://dx.doi.org/10.1155/2018/4398086.
Full textAbstract:
This study aims to investigate the effect of Chinese diet pattern of fat content (30% or 36.06%), n-6/n-3 polyunsaturated fatty acid (PUFA) ratio (5 : 1 or 9 : 1), and cholesterol content (0.04 or 0.057 g/kg total diet) on lipid profile using a rat model. Results showed that rats’ body weights (BWs) were controlled by the simultaneous intakes of cholesterol level of 0.04 g/kg total diet and n-6/n-3 ratio of 5 : 1. In addition, under high-fat diet, increased cholesterol feeding led to increased total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) levels and decreased triacylglycerols (TG) in rats’ plasma. However, high density lipoprotein cholesterol (HDL-C) level and the ratios of HDL-C/LDL-C and HDL-C/TC in rats’ plasma increased in response to simultaneous intakes of low n-6/n-3 ratio (5 : 1) and cholesterol (0.04 g/kg total diet) even under high-fat diet. Moreover, as the n-6/n-3 PUFA ratio in the diet decreased, the proportion of n-3 PUFAs increased in plasma, liver, and muscle and resulted in the decrease of n-6/n-3 PUFA ratio.
17
Carter, Sharayah, Alison M. Hill, Catherine Yandell, Jonathan D. Buckley, and Alison M. Coates. "Study protocol for a 15-week randomised controlled trial assessing the independent effects of high-cholesterol and high-saturated fat diets on LDL cholesterol." BMJ Open 14, no. 1 (January 2024): e081664. http://dx.doi.org/10.1136/bmjopen-2023-081664.
Full textAbstract:
IntroductionPrevious research has associated high dietary cholesterol intake with raised low-density lipoprotein cholesterol (LDL-C) and thus increased risk for cardiovascular disease (CVD). Emerging research suggests that it is saturated fat, not dietary cholesterol, associated with increased CVD risk. Despite being high in cholesterol, eggs, low in saturated fat, are not adversely associated with blood lipids or CVD risk. This paper describes a randomised controlled counter-balanced, cross-over trial assessing the effects of a high-cholesterol/low-saturated fat (egg) diet and a low-cholesterol/high-saturated fat diet (egg free) on blood lipids and lipoproteins, while accounting for physical activity levels which can also influence these parameters. The primary aim is to demonstrate that high cholesterol intake (from eggs) within a healthy, low-saturated fat diet does not adversely affect blood lipid levels and lipoprotein profiles. Instead, we propose that adverse effects on these parameters are mediated by saturated fat intake. The secondary aim is to explore relationships between changes in blood lutein and zeaxanthin concentrations and alterations in physical activity, examining whether changes in physical activity mediate effects on blood lipids and lipoproteins.Methods and analysisFifty-two adults aged 18–60 years with LDL-C less than 3.5 mmol/L will be randomly allocated to three isocaloric diets for 5 weeks each: a high-cholesterol (600 mg)/low-saturated fat (6%) (egg) diet, a low-cholesterol (300 mg)/high-saturated fat (12%) (egg free) diet and a control diet that is high in both cholesterol (600 mg) and saturated fat (12%). Lipid and lipoprotein levels, lipoprotein size and concentrations, blood pressure, blood glucose, physical activity levels, and plasma lutein and zeaxanthin concentrations will be measured. Treatment effects will be analysed using linear mixed effects models.Ethics and disseminationEthics approval was obtained from the University of South Australia Human Research Ethics Committee no. 204 327. Results will be disseminated through peer-reviewed journals and national and international presentations.Trial registration numberNCT05267522
18
Chang, Hao-Hsiang, Yi-Chan Lan, Shiu-Dong Chung, and Chiang-Ting Chien. "Sweet Potato Leaf Feeding Decreases Cholesterol, Oxidative Stress and Thrombosis Formation in Syrian Hamsters with a High-Cholesterol Diet." Life 11, no. 8 (August 9, 2021): 802. http://dx.doi.org/10.3390/life11080802.
Full textAbstract:
Nutritional strategies to reduce hyperlipidemia and the risk of cardiovascular disease are gaining more public favor and medical professionals’ attention. The authors of this study explored the effect of sweet potato leaf powder (SPLP) feeding on the parameters of plasma lipids, reactive oxygen species, and time to thrombosis formation in Syrian hamsters fed with high-cholesterol diets. The animals were separated into six groups: a feeding control diet, a control diet containing 0.1% cholesterol, a control diet containing 0.2% cholesterol, a control diet containing 0.1% cholesterol plus 2.5% SPLP, a control diet containing 0.1% cholesterol plus 5% SPLP, and a control diet containing 0.2% cholesterol plus 5% SPLP for six weeks. The levels of serum total cholesterol (51% increase), low-density lipoprotein cholesterol (70.6% increase), very-low-density lipoprotein cholesterol (51.3% increase), and the triglyceride and atherogenic index (LDL-C/HDL-C) significantly increased in the high-cholesterol diet groups. Concomitant 5% sweet potato leaf powder ingestion significantly decreased the lipid profiles, with a 20.6% total cholesterol reduction in the 0.1% cholesterol diet groups, a 17.2% reduction in the 0.2% group, a 48.7% LDL reduction in the 0.1% cholesterol group, and a 30.3% reduction in the 0.2% group, with a consequent decrease in the atherogenic index. SPLP feeding was found to be associated with increased fecal sterol contents, with a 188.6% increase in the 0.1% cholesterol-fed group and a 177.3% increase in the 0.2% group. The SPLP-fed groups had depressed ROS levels, elongated FeCl3-induced times to thrombosis formation, and increased liver superoxide dismutase contents and SREBP-1 protein expression. Sweet potato leaf intake could reduce plasma total cholesterol, LDL, and oxidative stress. We suggest sweet potato leaf intake as a choice of nutritional strategy for hyperlipidemia and cardiovascular disease prevention.
19
Syed, Misbah, Rubina Iqbal, Fatima Zahid, Samreen Manzoor, Shahzaib Wazir Qureshi, and Shoaib Muhammed Daniyal. "A Comparative Study of Cholesterol Levels in Non-Pregnant Females Taking Ketogenic Versus Low Calorie Diet." Pakistan Journal of Medical and Health Sciences 17, no. 3 (March 30, 2023): 550–53. http://dx.doi.org/10.53350/pjmhs2023173550.
Full textAbstract:
Introduction: Over the past few years, the population of Pakistan has become much aware of the need of weight loss and healthy lifestyle. We evaluated the cholesterol profiles to observe how keto diet and low-calorie diet influence the basic lipid profile of females. Aims: The aim of this study was to compare the cholesterol and triglyceride levels in adult non pregnant females taking ketogenic versus low calorie diet for a one month Methodology: The design of this study was a cross sectional study design. This study was conducted in lady reading hospital Peshawar and the duration of this study was from January 2022 to February 2022. 60 non pregnant females of age between 35-45 years with BMI ranging between 30-34.9 were included in the study. 30 were on low calorie diet, 30 were on keto diet. The serum cholesterol and triglyceride levels were calculated on day 1 and day 30 of the study. Results: The serum chloesterol levels were significantly reduced in individuals taking low calorie diet as compared to keto diet over a period of thirty days. After few weeks, anthropometric and body composition measurements revealed a significant reduction significant decrease in glucose and insulin blood levels were observed, together with a significant improvement of body weight. There was a significant, slightly decrease of LBM. A significant decrease of triglycerides, total cholesterol and LDL were observed along with a rise in HDL levels. The LH/FSH ratio, LH total and free testosterone, and DHEAS blood levels were also significantly reduced. Estradiol, progesterone and SHBG increased. The Ferriman Gallwey Score was slightly, although not significantly, reduced. Practical Implication: to determine the effects of a ketogenic diet (KD) in women age with a diagnosis of PCOS. We hypothesized that a modified KD (KEMEPHY diet) would lead to an improvement in body weight, plasma cholesterol, triglycerides, hyperinsulinemia, and hormonal outcomes Conclusion: Low calorie diet was significantly better than ketogenic diet in reducing serum cholesterol and triglyceride levels in individuals on a 30-day diet plan of respective type. Our results suggest that a ketogenic diet may be considered as a valuable nonpharmacological treatment for Polycystic ovary syndrome. Longer treatment periods should be tested to verify the effect of a ketogenic diet on the dermatological aspects of Polycystic ovary syndrome. Keywords: Cholesterol, Ketogenic Diet, Serum, Lifestyle, Low Calorie, Nutritionist
20
Bierman, E. L., and J. D. Brunzell. "Diet Low in Saturated Fat and Cholesterol for Diabetes." Diabetes Care 12, no. 2 (February 1, 1989): 162–63. http://dx.doi.org/10.2337/diacare.12.2.162.
Full text
21
Keelan, M., K. Walker, R. Rajotte, T. Clandinin, and A. B. R. Thomson. "Diets alter jejunal morphology and brush border membrane composition in streptozotocin-diabetic rats." Canadian Journal of Physiology and Pharmacology 65, no. 2 (February 1, 1987): 210–18. http://dx.doi.org/10.1139/y87-038.
Full textAbstract:
Previous studies have demonstrated enhanced active and passive uptake of many nutrients in animals with experimental diabetes. These changes in absorption cannot be explained by differences in intestinal morphology, although the brush border membrance (BBM) phospholipids do change in diabetes. Manipulation of diet produces alterations in intestinal uptake of lipids and glucose. This study was undertaken to determine the effect of diet and diabetes on jejunal morphology and BBM lipid composition. Rats were rendered hyperglycemic with streptozotocin and were fed for 2 weeks on a diet that was high or low in carbohydrate, essential fatty acids, cholesterol, or protein. In both control and diabetic rats, these diets produced changes in villus height and BBM sucrase and alkaline phosphatase activities. In both control and diabetic rats, BBM phospholipids were unaffected by changes in the dietary content of essential fatty acids, cholesterol, or protein, but total BBM phospholipid content was reduced in animals fed low as compared with high carbohydrate diet. Total BBM phospholipid content was higher in diabetic than in control animals fed the low protein diet, whereas BBM phospholipid content was lower in diabetic than in control animals fed the high carbohydrate diet, and was even lower in diabetic animals fed the low as compared with the high carbohydrate diet. These changes in total phospholipids were due to alterations in the BBM content of phospholipids containing choline. In control animals, BBM cholesterol was higher in rats fed the low as compared with the high cholesterol diet, or the low as compared with the high protein diet. In diabetic rats, BBM cholesterol was higher than in animals fed the low as compared with the high essential fatty acid or high protein diet. BBM cholesterol was higher in diabetic than in control rats only when fed the low essential fatty acid diet. The results show that (i) diabetes and dietary manipulation produce changes in villus morphology, BBM enzymes, and lipids, but there is no apparent relationship between alterations in the various parameters measured; and (ii) diet and diabetes may alter lipid uptake as a result of qualitative and quantitative changes in the choline phospholipids in the intestinal brush border membrane.
22
Quivers, Eric S., David J. Driscoll, Colleen D. Garvey, Ann M. Harris, Jay Harrison, Diane M. Huse, Paul Murtaugh, and William H. Weidman. "Variability in Response to a Low-Fat, Low-Cholesterol Diet in Children with Elevated Low-Density Lipoprotein Cholesterol Levels." Pediatrics 89, no. 5 (May 1, 1992): 925–29. http://dx.doi.org/10.1542/peds.89.5.925.
Full textAbstract:
The reduction of dietary cholesterol and fat lowers low-density lipoprotein cholesterol (LDL-C) and reduces risk of coronary heart disease in adults. The purpose of this study was to determine the individual variability of response of serum lipid and lipoprotein levels to a low-fat, low-cholesterol diet in children with elevated LDL-C levels. Thirty-two children (2 to 16 years of age) enrolled in a diet modification program, who had LDL-C levels of at least 110 mg/dL but normal triglyceride levels for their ages, were studied. Lipid levels and dietary nutrients were analyzed at the time of admission, and final assessments were made at least 3 months after entry. There was a significant correlation, for the group as a whole, between change in LDL-C concentration and change in grams of dietary saturated fat; however, there was marked individual variability in LDL-C response. There were no significant correlations between changes in LDL-C levels and changes in either total fat, polyunsaturated fat, or cholesterol intake. It is concluded that modest decreases in dietary saturated fat coincide with a lowering of LDL-C concentration, over a short term, in many children, but the degree of lowering varies considerably from one child to another. This variability is consistent with the concept that response of serum lipid levels to dietary changes is modified by genetic, metabolic, and other, as of yet, undefined variables.
23
Sanders, T. A. B. "Olive Oil and the Mediterranean Diet." International Journal for Vitamin and Nutrition Research 71, no. 3 (May 1, 2001): 179–84. http://dx.doi.org/10.1024/0300-9831.71.3.179.
Full textAbstract:
The high intake of olive oil in the Mediterranean diet contributes to the low intake of saturated fatty acids among populations in Southern Europe and is associated with a low incidence of coronary heart disease. Replacement of saturated fatty acids with oleic acid leads to a reduction in low-density lipoprotein (LDL) cholesterol without decreasing the concentration of high density lipoprotein (HDL) cholesterol. Oleic acid, however, may not be neutral with regards to its effects on risk of thrombosis which may have adverse consequences in populations with established atherosclerosis.
24
Hawton, Keith, Philip Cowen, David Owens, Alyson Bond, and Martin Elliott. "Low Serum Cholesterol and Suicide." British Journal of Psychiatry 162, no. 6 (June 1993): 818–25. http://dx.doi.org/10.1192/bjp.162.6.818.
Full textAbstract:
“Primary prevention trials which have shown that the lowering of serum cholesterol concentrations in middle-aged subjects by diet, drugs, or both leads to a decrease in coronary heart disease have also reported an increase in deaths due to suicide or violence. There has been no adequate explanation for this association. I have reviewed the relevant published work and describe a physiological mechanism that might account for this curious finding. One of the functions of serotonin in the central nervous system is the suppression of harmful behaviour impulses. When mouse brain synaptosomal membrane cholesterol is increased there is a pronounced increase in the number of serotonin receptors. Low membrane cholesterol decreases the number of serotonin receptors. Since membrane cholesterol exchanges freely with cholesterol in the surrounding medium, a lowered serum cholesterol concentration may contribute to a decrease in brain serotonin, with poorer suppression of aggressive behaviour.”
25
Smith, Brendon W., Jennifer L. King, Rita J. Miller, James P. Blue Jr., Sandhya Sarwate, William D. O'Brien Jr., and John W. Erdman Jr. "Optimization of a Low Magnesium, Cholesterol-Containing Diet for the Development of Atherosclerosis in Rabbits." Journal of Food Research 2, no. 1 (January 28, 2013): 168. http://dx.doi.org/10.5539/jfr.v2n1p168.
Full textAbstract:
<p>The cholesterol-fed rabbit is useful for atherosclerosis research. We describe development of a low-magnesium (Mg) cholesterol-containing diet to accelerate atherosclerosis in this model. Male New Zealand White rabbits were fed either chow or one of four atherogenic diets: 1% cholesterol 10% fat 0.11% Mg, 1% cholesterol 10% fat 0.40% Mg, 2% cholesterol 20% fat 0.11% Mg, or 2% cholesterol 20% fat 0.40% Mg. While feed intake decreased in cholesterol-fed rabbits, they were able to maintain their body weights. Rabbits consuming cholesterol experienced profound hypercholesterolemia and tissue lipid accumulation, with plasma cholesterol levels above 1500 mg/dl for all groups at the completion of the study. Liver and spleen lipid content and liver cholesterol content also increased. Aortic arch atheroma thickness was greatest in 1% cholesterol 10% fat 0.11% Mg animals. Tissue Mg levels decreased in cholesterol-fed animals compared to chow-fed controls, despite equal or greater serum Mg levels. Our results indicate that the 1% cholesterol 10% fat 0.11% Mg diet was optimal at promoting hypercholesterolemia and atherosclerosis while minimizing health complications for the animals. The low Mg cholesterol diet will be useful to other biomedical researchers interested in utilizing the rabbit for cardiovascular disease research.</p>
26
Cobb, Margaret M., and Howard Teitlebaum. "Determinants of plasma cholesterol responsiveness to diet." British Journal of Nutrition 71, no. 2 (February 1994): 271–82. http://dx.doi.org/10.1079/bjn19940133.
Full textAbstract:
Plasma cholesterol change, or ‘responsiveness’, to dietary saturated fat modification has long been acknowledged. The present study sought to determine the specific, predicted response of each cholesterol subfraction to known dietary manipulations. Two metabolically controlled diets, one with a low polyunsaturated:saturated fat (low P:S) ratio, and one with a high P:S ratio were fed in a crossover design to sixty-seven normolipidaemic subjects pooled from six foregoing metabolic studies. A series of statistical analyses was performed to identify the lipids and subfractions independently affected by the diet crossover. Multivariate analysis of variance revealed that the changes in total cholesterol (ΔTC), low-density-lipoprotein-cholesterol (ΔLDL-C), and high-density-lipoprotein-cholestero! (ΔHDL-C) were the only statistically significant diet-specific‘responsive’lipids. Multiple regression was performed to identify the independent predictors of ΔTC, ΔLDL-C and ΔHDL-C. It was found that age (years), extent of change in dietary saturated fat, and baseline LDL-C (mg/l) levels determine LDL-C change, while extent of change in saturated and polyunsaturated fat, and baseline HDL-C (mg/l) levels can predict HDL-C change. A series of equations to predict lipoprotein responsiveness to diet are derived for potential use in clinical practice.
27
Wells, Anita S., Nicholas W. Read, Jonathan D. E. Laugharne, and N. S. Ahluwalia. "Alterations in mood after changing to a low-fat diet." British Journal of Nutrition 79, no. 1 (January 1998): 23–30. http://dx.doi.org/10.1079/bjn19980005.
Full textAbstract:
The effects on mood of reducing dietary fat while keeping the energy constant were examined in ten male and ten female healthy volunteers aged between 20 and 37 years. Each volunteer consumed a diet containing 41% energy as fat for 1 month. For the second month half of the subjects changed to a low-fat diet (25% energy from fat) and the remainder continued to eat the diet containing 41% energy from fat. Changes in mood and blood lipid concentrations were assessed before, during and at the end of the study. Profile of mood states (POMS) ratings of anger–hostility significantly increased in the intervention group after 1 month on the low-fat diet, while during the same period there was a slight decline in anger–hostility in the control subjects (group F 6.72; df 1,14; P = 0.021). Tension–anxiety ratings declined in the control group consuming the higher fat diet but did not change in the group consuming the low-fat diet (group F 6.34; df 1,14; P = 0.025). There was a decline in fasting concentrations of HDL-cholesterol after the low-fat diet and a small increase in subjects consuming the medium-fat diet (group F 4.96; df 1,12; P = 0.046), but no significant changes in concentrations of total serum cholesterol, LDL-cholesterol or triacylglycerol were observed. The results suggest that a change in dietary fat content from 41 to 25% energy may have adverse effects on mood. The alterations in mood appear to be unrelated to changes in fasting plasma cholesterol concentrations.
28
Azadbakht, Leila, Parvin Mirmiran, Ahmad Esmaillzadeh, and Fereidoun Azizi. "Better dietary adherence and weight maintenance achieved by a long-term moderate-fat diet." British Journal of Nutrition 97, no. 2 (February 2007): 399–404. http://dx.doi.org/10.1017/s0007114507328602.
Full textAbstract:
The objective of the present study was to determine the effects of a long-term moderate-fat diet (30 % energy from fat)v.a low-fat one (20 % energy from fat) on metabolic risks. The study was a randomised, prospective 14-month trial on overweight and obese patients (eighty-nine overweight and obese men and women). The intervention was a moderate-fat diet (30 % energy) or a low-fat diet (20 % energy). The main outcome measurements were change in body weight, waist circumference, LDL-cholesterol, HDL-cholesterol, total cholesterol, TAG, and systolic and diastolic blood pressure. Forty-five subjects on the moderate-fat diet and forty-four subjects on the low-fat one were studied. Characteristics of all randomised participants were similar in both groups. After 7 months, the moderate- and low-fat diets had similar effects on cardiovascular risks. The moderate-fat diet was more successful after 14 months in reducing weight ( − 5·0 (sd2·5) kg in the moderate-fat groupv.− 1·2 (sd1·1) kg in the low-fat one;P < 0·0001), waist circumference ( − 5·5 (sd2·4) cm in the moderate-fat groupv.− 2·3 (sd1·3) cm in the low-fat one;P < 0·0001), and other cardiovascular risk factors as well (LDL, TAG, total cholesterol and systolic blood pressure). In conclusion, a moderate-fat energy-restricted diet in the long term might have more beneficial effects on weight maintenance and cardiovascular risk factors compared with a low-fat diet. Better dietary adherence with the moderate-fat diet may be the reason for its successful effects.
29
Temmerman, A. M., R. J. Vonk, K. Niezen-Koning, R. Berger, and J. Fernandes. "Effects of dietary cholesterol in the Mongolian gerbil and the rat: a comparative study." Laboratory Animals 23, no. 1 (January 1, 1989): 30–35. http://dx.doi.org/10.1258/002367789780886948.
Full textAbstract:
To come to a better understanding of the diet-induced cholesterol-ester storage in the gerbil liver, the reactions of the gerbil to 0·2% of cholesterol in the diet during 4 weeks were compared with those of the rat consuming the same diet. The major reason for the increased hepatic cholesterol-ester storage in the cholesterol-fed gerbil is the low cholesterol turnover in this species. This contrasts with the rat. Although faecal acidic steroid excretion can be slightly increased during cholesterol feeding in the gerbil, this increase is not sufficient to compensate for the quantity of dietary cholesterol when administered at the 0·2% level.
30
Kwiterovich, Peter O. "The Role of Fiber in the Treatment of Hypercholesterolemia in Children and Adolescents." Pediatrics 96, no. 5 (November 1, 1995): 1005–9. http://dx.doi.org/10.1542/peds.96.5.1005.
Full textAbstract:
The effect of adding water-soluble fiber to a diet low in total fat, saturated fat, and cholesterol to treat hypercholesterolemic children and adolescents with elevated plasma low-density lipoprotein (LDL) cholesterol levels was assessed. In more than a half-dozen studies, the effect of water-soluble fiber on the LDL cholesterol level ranged from no change to as high as a 23% decrease using oat bran, psyllium, or locust bean gum. The wide range of effects in these studies may be related to the quality of the dietary intervention or to different methods of randomization, blinding, dietary assessment, and laboratory measurement. For example, the addition of supplemented soluble fiber (psyllium) to a step 1 diet may provide additional lowering of LDL cholesterol of 10% to 15%. However, in children consuming the more stringent step 2 diet, the addition of water-soluble fiber may have less additional effects on LDL cholesterol. As recommended by the National Cholesterol Education Program Expert Panel on Blood Cholesterol Levels in Children and Adolescents, dietary therapy, that is, a diet low in total fat, saturated fat, and cholesterol, remains the cornerstone of treatment for children and adolescents with elevated LDL cholesterol levels. The use of foods high in water-soluble fiber that contain no cholesterol and are low in saturated fat remains a good choice in children following a step 1 or step 2 diet. Additional clinical trials in larger numbers of well-defined subjects will be needed to assess further the utility of adding water-soluble fiber supplements to the National Cholesterol Education Program step 1 or step 2 diets. The addition of drug therapy in children with elevated LDL cholesterol levels should be undertaken only in those with more marked elevations in the LDL cholesterol levels, particularly in those with positive family histories of premature coronary artery disease and the presence of two or more other coronary artery disease risk factors.
31
Bashan, İbrahim, and Mustafa Bakman. "The Effect of Daily Walnut Consumption on Dyslipidemia." Journal of Food Quality 2018 (June 21, 2018): 1–6. http://dx.doi.org/10.1155/2018/4731826.
Full textAbstract:
The aim of this study was to investigate the effect of daily walnut consumption on dyslipidemia in dietary. Within a year, the patients who have been suggested taking walnut or not in their individual dietary were scanned retrospectively and randomized into 2 groups. The first group consists of 72 cases (only those taken on the diet program) and the second group consists of 73 cases (walnut consumption in regulated diet). Baseline blood lipid parameters and anthropometric measurements were assessed in both groups and compared with values at 3rd month. p values < 0.05 were considered statistically significant. In addition, Maras 18 walnut cultivar was analyzed to determine the fatty acid profiles by chromatographic technique. When comparing lipid parameters at baseline and at the 3rd month, total cholesterol, low-density lipoprotein cholesterol, very low-density lipoprotein cholesterol, and triglyceride levels significantly decreased and high-density lipoprotein cholesterol levels significantly increased. As compared with the end of 3rd month values of the groups, the reduction in total cholesterol, low-density lipoprotein cholesterol, very low-density lipoprotein cholesterol, triglyceride levels of the subjects group (walnut consumption in regulated diet) were significantly higher than the control group (only regulated diet). Also, there was no significant difference in increase on high-density lipoprotein cholesterol levels between the groups. The results showed that daily consumption of walnut improved blood lipid levels. However, more extensive studies are needed on therapeutic usage in dyslipidemia.
32
Aro, Antti, Pirjo Pietinen, Liisa M. Valsta, Anu M. Turpeinen, Christian Ehnholm, Rita M. Dougherty, and James M. Iacono. "Effects of reduced-fat diets with different fatty acid compositions on serum lipoprotein lipids and apolipoproteins." Public Health Nutrition 1, no. 2 (June 1998): 109–16. http://dx.doi.org/10.1079/phn19980017.
Full textAbstract:
AbstractObjective:To compare the effects on serum lipoproteins of three isocaloric diets with reduced total fat and saturated fatty acid (SFA) contents but with different proportions of monounsaturated (MUFA) and polyunsaturated fatty acids (PUFA).Design:A low-fat diet (LF) provided 20 en% fat, 7.9% SFA, 7.8% MUFA, 3.0% PUFA; a high-PUFA diet (HP) 26 en% fat, 7.5% SFA, 8.2% MUFA, 8.1% PUFA; and a high-MUFA diet (HM) 26 en% fat, 7.3% SFA, 14.1% MUFA, 3.2% PUFA. Diets were consumed for 8 weeks in a parallel design, after 2 weeks on a habitual diet with 33–34 en% fat, 13–14% SFA, 12% MUFA, 6% PUFA, and followed by an 8-week period on habitual diet. Compliance to diet was monitored by repeated food records and weekly visits to a nutritionist.Subjects:45 free-living, middle-aged couples who were randomly allocated into the three diet groups; 43 men and 44 women completed the study.Results:During the diet periods, a small but significant reduction in body weight of 0.4–1.0kg was observed in all groups. Similar and significantreductions of mean weight-adjusted serum total cholesterol (4–8%), low-density lipoprotein (LDL) cholesterol (7–11%), and high-densitylipoprotein (HDL) cholesterol (8–11%) were observed during the diets. HDL2-cholesterol and apoprotein (apo) A-I levels were reduced whereas HDL3-cholesterol and apoA-II increased. ApoB was significantly decreased during the HM diet only. Serum triglycerides increased significantly during diets LF (25%, P< 0.01) and HP (19%, P< 0.05) but not during diet HM (5%, NS).Conclusions:Reduction in the intake of total fat and saturated fatty acids reduced serum LDL-cholesterol and HDL2-cholesterol concentrations irrespective of the relative proportions of MUFA and PUFA in the diets. The results suggest that there might be some advantage in increasing the proportion of MUFA in low-fat diets, since the HM diet rich in MUFA reduced apoB and slightly attenuated the increase in serum triglycerides that is commonly associated with dietary fat reduction.
33
van Bennekum, Ariëtte M., David V. Nguyen, Georg Schulthess, Helmut Hauser, and Michael C. Phillips. "Mechanisms of cholesterol-lowering effects of dietary insoluble fibres: relationships with intestinal and hepatic cholesterol parameters." British Journal of Nutrition 94, no. 3 (September 2005): 331–37. http://dx.doi.org/10.1079/bjn20051498.
Full textAbstract:
Fibres with a range of abilities to perturb cholesterol homeostasis were used to investigate how the serum cholesterol-lowering effects of insoluble dietary fibres are related to parameters of intestinal cholesterol absorption and hepatic cholesterol homeostasis in mice. Cholestyramine, chitosan and cellulose were used as examples of fibres with high, intermediate and low bile acid-binding capacities, respectively. The serum cholesterol levels in a control group of mice fed a high fat/high cholesterol (HFHC) diet for 3 weeks increased about 2-fold to 4·3 mm and inclusion of any of these fibres at 7·5 % of the diet prevented this increase from occurring. In addition, the amount of cholesterol accumulated in hepatic stores due to the HFHC diet was reduced by treatment with these fibres. The three kinds of fibres showed similar hypocholesterolaemic activity; however, cholesterol depletion of liver tissue was greatest with cholestyramine. The mechanisms underlying the cholesterol-lowering effect of cholestyramine were (1) decreased cholesterol (food) intake, (2) decreased cholesterol absorption efficiency, and (3) increased faecal bile acid and cholesterol excretion. The latter effects can be attributed to the high bile acid-binding capacity of cholestyramine. In contrast, incorporation of chitosan or cellulose in the diet reduced cholesterol (food) intake, but did not affect either intestinal cholesterol absorption or faecal sterol output. The present study provides strong evidence that above all satiation and satiety effects underlie the cholesterol-lowering properties of insoluble dietary fibres with moderate or low bile acid-binding capabilities.
34
Cambri, L. T., A. C. Ghezzi, G. Arsa, J. D. Botezelli, and M. A. R. de Mello. "Standard short-term diet ameliorates the lipid profile altered by a fructose-rich diet in rats." Journal of Developmental Origins of Health and Disease 6, no. 4 (April 8, 2015): 335–41. http://dx.doi.org/10.1017/s2040174415001026.
Full textAbstract:
Markers of metabolic abnormalities are commonly found in rodents fed a fructose-rich diet. The purpose of this study was to determine whether the administration of a short-term standard diet to rats is able to improve the lipid profile altered by a fructose-rich diet. The male pups, immediately after birth, were divided in three groups according to the diet for 90 days. Standard diet: a standard diet for the whole experimental period; fructose (60% fructose-rich diet): fructose-rich diet during the entire experimental period; fructose/standard (FS): fructose-rich diet from the neonatal period up to 60 days of age and standard diet from 60 to 90 days of age. A fructose-rich diet from the neonatal period to 60 days reduced weight gain (P<0.05), as well as the weight of adipose tissues in all the regions analyzed (epididymal, mesenteric, retroperitoneal and posterior subcutaneous), and it altered the lipid profile (elevation of triglycerides, total cholesterol, low density lipoprotein (LDL) cholesterol and very low density lipoprotein (VLDL) cholesterol;P<0.05). When a standard diet was administered after the fructose-rich diet, it was able to partially reverse changes to the lipid profile, as total cholesterol levels were significantly different in all the groups (P<0.05), and triglyceride and VLDL cholesterol levels were similar between the control and FS group. In summary, a fructose-rich diet altered the lipid profile, and a standard diet can partially reverse the changed parameters in short term.
35
An, Hyo-Jin, Na-Hyung Kim, Yun-Kyung Kim, Yeoung-Su Lyu, Taekyun Shin, Seung-Heon Hong, and Hyung-Min Kim. "Reductive effect of body weight in C57BL/6J mice fed a high-fat diet by Saesaengmyung Diet." Canadian Journal of Physiology and Pharmacology 83, no. 2 (February 1, 2005): 161–65. http://dx.doi.org/10.1139/y04-135.
Full textAbstract:
The Saesaengmyung Diet (SD) is a newly developed dietary product to help control weight. The aim of this study was to evaluate whether SD combined with a high-fat (HF) diet could influence body weight, fat accumulation, and glucose levels in blood. C57BL/6J mice were fed for 8 weeks with a standard diet, an HF diet, and an HF + 10% or HF + 20% SD diet. Body weight was recorded weekly, and plasma levels of total cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and glucose were analyzed at the end of the study. Weight increases in the 10% or 20% SD group were significantly less than in the HF diet group (p < 0.05). Plasma total cholesterol level significantly decreased by 33.5% in the 10% SD group and 38.8% in the 20% SD group, but the LDL cholesterol, HDL cholesterol, and glucose levels in the SD groups were not significantly changed. Our findings indicate that SD may be beneficial to overweight individuals in the reduction of weight gain induced by an HF diet.Key words: Saesaengmyung Diet, high-fat diet, obesity, body weight, cholesterol, glucose.
36
Guevara-Cruz, Martha, Isabel Medina-Vera, Adriana Flores-López, Miriam Aguilar-López, Caren E. Smith, Laurence D. Parnell, Yu-Chi Lee, et al. "Development of a Genetic Score to Predict an Increase in HDL Cholesterol Concentration After a Dietary Intervention in Adults with Metabolic Syndrome." Journal of Nutrition 149, no. 7 (May 9, 2019): 1116–21. http://dx.doi.org/10.1093/jn/nxz060.
Full textAbstract:
ABSTRACT Background Dietary intervention (DI) is a primary strategy to attenuate some of the metabolic abnormalities associated with metabolic syndrome (MetS), including low HDL cholesterol. There is no biomarker that can identify individuals who respond to DI by increasing HDL cholesterol. Objective The aim of this study was to assess the predictive power of a genetic predisposition score (GPS) in Mexican adults with MetS to identify HDL cholesterol responders to DI. Methods This study followed a prospective cohort design. Sixty-seven Mexican adults aged 20–60 y (21% men) with BMI ≥25 and ≤39.9 kg/m², who had at least 3 of 5 positive criteria for MetS, were included. Participants consumed a low saturated fat diet for 2.5 mo (<7% energy as saturated fat, <200 mg of cholesterol/d) and reduced their usual diet by ∼440 kcal/d, a reduction in total energy intake of about 25%. Anthropometry and serum biochemical markers, including HDL cholesterol, were measured before and after DI. A multilocus GPS was constructed using previously reported genetic variants associated with response to diet in subjects with MetS. GPS values, designed to predict the response of HDL cholesterol to the DI, were computed for each individual as the sum of the number of effect alleles across 14 SNPs. Results Individuals were dichotomized as high and low GPS according to median GPS (−2.12) and we observed a difference in HDL cholesterol changes on DI of +3 mg/dL (6.3%) in subjects with low GPS, whereas those with high GPS had HDL cholesterol decreases of −3 mg/dL (−7.9%) (P = 0.04). Conclusions Individuals with low GPS showed greater increases in their HDL cholesterol than those with high GPS. Therefore, the GPS can be useful for predicting the HDL cholesterol response to diet.
37
Chiu, Chen-Yuan, Tsai-En Yen, Shing-Hwa Liu, and Meng-Tsan Chiang. "Comparative Effects and Mechanisms of Chitosan and Its Derivatives on Hypercholesterolemia in High-Fat Diet-Fed Rats." International Journal of Molecular Sciences 21, no. 1 (December 21, 2019): 92. http://dx.doi.org/10.3390/ijms21010092.
Full textAbstract:
The present study investigated and compared the effects of different molecular weights of chitosan (high molecular weight chitosan (HC) and low molecular weight chitosan (LC)) and its derivatives (chitosan oligosaccharide (CO)) on cholesterol regulation in high-fat (HF) diet-fed rats. A diet supplementation of 5% HC, 5% LC, or 5% CO for 8 weeks showed hypocholesterolemic potential in HF diet-fed rats. Unexpectedly, a 5% CO-supplemented diet exerted hepatic damage, producing increased levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and tumor necrosis factor-alpha (TNF-α). The supplementation of HC and LC, unlike CO, significantly decreased the hepatic total cholesterol (TC) levels and increased the fecal TC levels in HF diet-fed rats. The hepatic protein expression of the peroxisome proliferator-activated receptor-α (PPARα) in the HF diet-fed rats was markedly decreased, which could be significantly reversed by both HC and LC, but not CO, supplementation. Unlike the supplementation of CO, both HC and LC supplementation could effectively reverse the HF-inhibited/induced gene expressions of the low-density lipoprotein receptor (LDLR) and cholesterol 7α-hydroxylase (CYP7A1), respectively. The upregulated intestinal acyl-CoA cholesterol acyltransferase 2 (ACAT2) protein expression in HF diet-fed rats could be reversed by HC and LC, but not CO, supplementation. Taken together, a supplementation of 5% CO in HF diet-fed rats may exert liver damage via a higher hepatic cholesterol accumulation and a higher intestinal cholesterol uptake. Both HC and LC effectively ameliorated the hypercholesterolemia and regulated cholesterol homeostasis via the activation and inhibition of hepatic (AMPKα and PPARα) and intestinal (ACAT2) cholesterol-modulators, respectively, as well as the modulation of downstream signals (LDLR and CYP7A1).
38
En Masrika, Nur Upik, Aryadi Arsyad, Ika Yustisia, and Yulia Yusrini Djabir. "Efek Diet Tinggi Protein, Rendah Karbohidrat, Rendah Lemak pada Tikus Wistar Jantan terhadap Perubahan Berat Badan, Kadar Glukosa dan Kolesterol." JUMANTIK (Jurnal Ilmiah Penelitian Kesehatan) 6, no. 1 (February 8, 2021): 33. http://dx.doi.org/10.30829/jumantik.v6i1.7891.
Full textAbstract:
<p class="AbstractTitle"><em>One of the most popular diets today recommends a high protein- low carbohydrate diet as a weight loss strategy in obese patients. Diets high in protein appear to reduce appetite, energy intake, weight gain, and fat accumulation. The application of a high-protein diet has an impact on reducing the portion of other macronutrients, namely carbohydrates and fats. The purpose of this study was to determine the effect of a high protein, low carbohydrate and low fat (TPRKRL) diet on body health. With the focus of the analysis on changes in body weight, serum glucose and cholesterol levels in 22 male Wistar rat samples who were given the standard diet and the TPRKRL diet for 8 weeks. The results showed that there were no significant differences in the variables of body weight, serum glucose and cholesterol levels between the TPRKRL diet group and the control group (standard diet). In fact, the rats in the TPRKRL group experienced a relatively constant increase in body weight and glucose and cholesterol levels were susceptible to normal.</em></p><p class="AbstractTitle"><em>Keywords: high protein; body weight; glucose; cholesterol</em><em></em></p>
39
Burén, Jonas, Madelene Ericsson, Nágila Raquel Teixeira Damasceno, and Anna Sjödin. "A Ketogenic Low-Carbohydrate High-Fat Diet Increases LDL Cholesterol in Healthy, Young, Normal-Weight Women: A Randomized Controlled Feeding Trial." Nutrients 13, no. 3 (March 2, 2021): 814. http://dx.doi.org/10.3390/nu13030814.
Full textAbstract:
Ketogenic low-carbohydrate high-fat (LCHF) diets are popular among young, healthy, normal-weight individuals for various reasons. We aimed to investigate the effect of a ketogenic LCHF diet on low-density lipoprotein (LDL) cholesterol (primary outcome), LDL cholesterol subfractions and conventional cardiovascular risk factors in the blood of healthy, young, and normal-weight women. The study was a randomized, controlled, feeding trial with crossover design. Twenty-four women were assigned to a 4 week ketogenic LCHF diet (4% carbohydrates; 77% fat; 19% protein) followed by a 4 week National Food Agency recommended control diet (44% carbohydrates; 33% fat; 19% protein), or the reverse sequence due to the crossover design. Treatment periods were separated by a 15 week washout period. Seventeen women completed the study and treatment effects were evaluated using mixed models. The LCHF diet increased LDL cholesterol in every woman with a treatment effect of 1.82 mM (p < 0.001). In addition, Apolipoprotein B-100 (ApoB), small, dense LDL cholesterol as well as large, buoyant LDL cholesterol increased (p < 0.001, p < 0.01, and p < 0.001, respectively). The data suggest that feeding healthy, young, normal-weight women a ketogenic LCHF diet induces a deleterious blood lipid profile. The elevated LDL cholesterol should be a cause for concern in young, healthy, normal-weight women following this kind of LCHF diet.
40
Auliana, Rizqie, Fitri Rahmawati, Wara Kushartanti, Cerika Rismayanthi, Kukuh Wahyudin Pratama, Manil Kara Kauki, Reza Adityas Trisnadi, et al. "The study of rice bran cookies for diabetic diet and dyslipidemic diet." Fizjoterapia Polska 24, no. 1 (March 22, 2024): 258–65. http://dx.doi.org/10.56984/8zg2ef8m5d.
Full textAbstract:
This study is about the use of rice bran as a snack for people with degenerative diseases of diabetes mellitus and hypercholesterolemia. Non-Communicable Diseases (NCDs) are the highest cause of death and result in loss of productive days for sufferers and companions. To overcome this problem, the study aims to test rice bran cookies with 30% substitution on glucose levels, cholesterol levels, and triglyceride levels in experimental animals so that they can be recommended as healthy cookies low in sugar and low in fat for a snack for people with diabetes mellitus and dyslipidemia. This type of research is an experiment. Research location of the Inter-University Center Experimental Animal Laboratory (PAU) Gadjah Mada University (UGM). The initial stage is to prepare 15 male Sprague Dawley (SD) male white rats weighing 250-300 grams and in closed cages. Rats measured blood glucose levels, total cholesterol and triglycerides. Furthermore, the rats were grouped into 3 groups, and 2 groups were given an injection of streptozotocin (STZ) to make the rats diabetic. Group 1: 5 healthy rats fed a standard diet, group 2: 5 diabetic rats fed a standard diet, and group 3: 5 diabetic rats fed with rice bran cookies. Drinking water is given ad libitum and feeding is given every morning. Furthermore, weighing and analysis of blood glucose levels, total cholesterol, and triglycerides were carried out on the seventh, tenth, seventeenth, twenty-fourth, thirty-first, and thirty-eighth days. The results showed that 30% substitute bran cookies were able to reduce glucose levels, cholesterol levels, and serum triglyceride levels so that they could be recommended as a snack for people with diabetes mellitus and people with dyslipidemia.
41
Miettinen and Gylling. "Non-Nutritive Bioactive Constituents of Plants: Phytosterols." International Journal for Vitamin and Nutrition Research 73, no. 2 (March 1, 2003): 127–34. http://dx.doi.org/10.1024/0300-9831.73.2.127.
Full textAbstract:
Normal human diet contains small amounts of phytosterols, mainly sitosterol and campesterol. Intestinal absorption of these plant sterols is low, about one tenth of that of cholesterol, such that their serum concentrations are also low, about 0.1 to 1% of the cholesterol levels. Like cholesterol they are transported by lipoproteins, mainly by LDL, and secreted unchanged in bile. Addition of plant sterols, or especially of their delta-5 saturated derivatives plant stanols into diet as fat-soluble esters inhibit cholesterol absorption and lower serum cholesterol similarly in short-term studies. Long-term consumption of plant stanol esters lowers serum cholesterol to the extent expected to reduce clinical manifestation of coronary heart disease by over 20% without detectable side effecs, cholesterol lowering being especially effective in combination with cholesterol synthesis inhibitors statins.
42
Mudlikah, Siti, Suprapti Suprapti, and Khilyatus Shoihah. "The Effect of Fat Consumption Intake, Obesity and Cholesterol Level On Fertility Of Women." Jurnal Midpro 13, no. 2 (December 29, 2021): 147–53. http://dx.doi.org/10.30736/md.v13i2.303.
Full textAbstract:
Excess fat intake can lead to accumulation of body fat, obesity, high cholesterol levels cause disruption of female menstrual cycle hormone production. The purpose of study was to determine the effect of excess fat intake, obesity, high cholesterol levels on menstrual cycle and to determine the difference before and after the intervention of a low diet in saturated fat nutrition.The type of research is Analytical Observational study, design Cross Sectional, Logistic Regression Test and T-test of paired sample. Implementation January-June 2021. The population is 480 women of childbearing age (WCA). The instuments are questionnaire and observation. Random sampling technique 218 WCA. The form of nutritional diet intervention is low in saturated fat at least 4-5 days a week for 3 months.Results: Significant fat intake 0.000<0.05. , Obesity 0.001<0.05. Cholesterol level value of 0.001 <0.00 has an effect on menstrual cycle and there is a difference before and after the intervention of diet nutrition low in saturated fat obesity 0.000 <0.05, cholesterol sig 0.000 <0.05, menstrual cycle 0.000 <0.05.Conclusion: Excess fat intake, obesity, high cholesterol levels affect menstrual cycle and there are differences before and after the intervention of a diet low in saturated fat nutrition.
43
Abu-Hiamed, Hind. "Hypocholesterolemic effects of watermelon fruit rind on rats." Nutrition & Food Science 48, no. 5 (September 10, 2018): 836–45. http://dx.doi.org/10.1108/nfs-02-2018-0038.
Full textAbstract:
Purpose Watermelon (Citrullus lanatus) fruit and its rind are known to contain phytochemicals that may have health benefits. The aim of this paper is to investigate the potential hypocholesterolemic effect of watermelon fruit rind (WR) using rats who are fed a high-cholesterol diet. Design/methodology/approach Rats were divided into six groups and fed diets for eight weeks containing normal control diet or normal control diet with either 1% cholesterol, 5% WR, 10% WR, 1% cholesterol + 5% WR or 1% cholesterol + 10% WR. Triglycerides, total cholesterol and lipoprotein levels in serum and liver samples were determined, and histopathological examination of liver tissues was carried out. Findings Diets containing 1% cholesterol led to hypercholesterolemia, characterized by increased levels of total cholesterol and low-density lipoproteins in rat serum and liver samples. Incorporation of 10% WR into the diet of the otherwise hypercholesterolemic rats led to significant reduction in serum levels of total cholesterol (from 266.2 to 222.7 mg/dL) and low-density lipoproteins (from 159.5 to 94.4 mg/dL). In addition, these rats also exhibited improvements in hepatic tissue structure compared to the hypercholesterolemic rats. Originality/value These results support the potential use of WR as a hypocholesterolemic agent. Further research is needed to ascertain the hypocholesterolemic effect of WR in human.
44
Bila, G., O. Vishchur, V. Vovk, S. Vari, and R. Bilyy. "Neutrophil activation at high-fat high-cholesterol and high-fructose diets induces low-grade inflammation in mice." Ukrainian Biochemical Journal 96, no. 2 (April 25, 2024): 27–37. http://dx.doi.org/10.15407/ubj96.02.027.
Full textAbstract:
Nonalcoholic fatty liver disease (NAFLD), which can progress to nonalcoholic steatohepatitis (NASH), is a significant health concern affecting a substantial portion of the population. This study investigates the role of neutrophil extracellular traps (NETs) in liver inflammation induced by high-fat high-cholesterol diet (HFHCD) and high-fructose diet (HFD). The chronic nature of NAFLD involves low-grade inflammation with cytokine elevation. The research aims to visualize neutrophil elastase (NE) activity during HFHCD and HFD representing conditions of low-grade activation and assess neutrophil functional status. The study employs a mouse model subjecting animals to HFHCD, HFD or a standard diet (SD) for six weeks. Various analyses were used including histological evaluations, in vivo imaging of NE activity using a fluorescent probe, fluorescent microscopy, flow cytometry and assessment of neutrophil function through reactive oxygen species (ROS) levels. Mice on HFHCD and HFD display liver damage consistent with NASH, which was validated pathohistologically. NE activity in blood significantly increases after six weeks indicating systemic NETs involvement. In vivo imaging confirms NE activity in multiple organs. Cellular localization reveals NETs persistence even after neutrophil destruction in splenocytes indicating systemic involvement. Neutrophils under HFHCD exhibit a functional phenotype associated with low-grade inflammation, higher basal ROS levels and reduced activation potential. This study establishes the systemic impact of NETs in HFHCD- and HFD-induced liver inflammation, providing insights into the functional state of neutrophils. The findings contribute to understanding the mechanisms underlying chronic liver conditions and may inform future therapeutic strategies. Keywords: high fat diet, in vivo imaging, low-grade inflammation, NASH, neutrophil elastase, neutrophil extracellular traps, neutrophils
45
de Luis, Daniel Antonio, Rocío Aller, Olatz Izaola, G. Díaz Soto, J. J. López Gómez, E. Gómez Hoyos, B. Torres, A. Villar, and Enrique Romero. "Effects of a High-Protein/Low-Carbohydrate versus a Standard Hypocaloric Diet on Weight and Cardiovascular Risk Factors during 9 Months: Role of a Genetic Variation in the Cannabinoid Receptor Gene (CNR1) (G1359A Polymorphism)." Annals of Nutrition and Metabolism 66, no. 2-3 (2015): 125–31. http://dx.doi.org/10.1159/000375412.
Full textAbstract:
Objective: We decided to investigate the role of this polymorphism on cardiovascular risk factors and weight loss secondary to a high-protein/low-carbohydrate vs. a standard hypocaloric diet (1,000 kcal/day) over a period of 9 months. Material and methods: A nutritional evaluation was performed at the beginning and at the end of a 9-month period in which subjects received 1 of 2 diets (diet HP: high protein/low carbohydrate vs. S: standard diet). Results: One hundred and four patients (54.7%) had the genotype G1359G and 86 (45.3%) patients had G1359A (77 patients, 25.8%) or A1359A (9 patients, 3.7%) (A-allele-carriers). In subjects with both genotypes, the body mass index, weight, fat mass, waist circumference and systolic blood pressures decreased with both diets. After the diet type HP and in subjects with both genotypes, the glucose, leptin, total cholesterol, LDL-cholesterol, insulin and HOMA-R levels decreased. After diet S and in all subjects, the total cholesterol, LDL cholesterol and leptin levels decreased, too. Conclusion: Our interventional study didn't show a relationship between the rs1049353 CNR-1 polymorphism and body weight response after two different hypocaloric (low carbohydrate/high protein vs. standard) diets over a period of 9 months. However, a low-carbohydrate/high-protein diet for 9 months improved glucose metabolism in subjects with both genotypes.
46
Schlegelmilch, Brandsch, Stangl, and Eder. "Molasses Increases HDL Cholesterol in Rats Research Note." International Journal for Vitamin and Nutrition Research 75, no. 3 (May 1, 2005): 211–17. http://dx.doi.org/10.1024/0300-9831.75.3.211.
Full textAbstract:
Two experiments were conducted to determine whether molasses might exert effects on serum lipoproteins. In experiment 1, 24 rats were divided into two groups and fed diets containing liquid molasses from sugar beet or sucrose (7.71 g of molasses dry matter or sucrose per kg of diet). The second experiment included four groups of rats (n = 12/group) and was conducted in a bifactorial design, with the factors being molasses (non-supplementation vs. supplementation of 77.1 g of molasses dry matter per kg of diet at the expense of sucrose) and dietary cholesterol (0 vs. 5 g/kg diet). In experiment 1, the ratio of low-density lipoprotein (LDL) to high-density lipoprotein (HDL) cholesterol concentration tended to be lower in rats fed the molasses diet than in rats fed the control diet (p < 0.15). In experiment 2, rats fed the molasses diet had higher concentrations of HDL cholesterol (+ 26%) than control rats fed diets without molasses (p < 0.05). This effect was independent of the dietary cholesterol concentration. Concentrations of cholesterol in LDL, very low-density lipoprotein (VLDL), and liver as well as concentrations of triacylglycerols in plasma and liver remained unaffected by molasses in both experiments. In conclusion, the results of this study suggest that supplementation of molasses is effective at raising HDL cholesterol levels in rats.
47
Vaskonen, Timo, Eero Mervaala, Ville Sumuvuori, Tuulikki Seppänen-Laakso, and Heikki Karppanen. "Effects of calcium and plant sterols on serum lipids in obese Zucker rats on a low-fat diet." British Journal of Nutrition 87, no. 3 (March 2002): 239–45. http://dx.doi.org/10.1079/bjn2001508.
Full textAbstract:
Ca may interfere with fat and cholesterol metabolism through formation of insoluble soaps with fatty and bile acids in the intestine. In the present study, we examined the effects of different dietary Ca levels on the serum lipid profile and cholesterol metabolism in obese Zucker rats fed a low-fat diet. We also tested whether dietary Ca interfered with the lipid-lowering effects of a pine oil-derived plant sterol mixture. Increase in dietary Ca intake from 0·2 to 0·8 %, and further to 2·1 % (w/w) dose-dependently decreased serum total cholesterol (r -0·565, P=0·002, n 27), LDL-cholesterol (r -0·538, P=0·006, n 25), and triacylglycerol (r -0·484, P=0·014, n 25) concentrations, and increased HDL-cholesterol (r 0·478, P=0·016, n 25) and HDL : LDL cholesterol (r 0·672, P<0·001, n 25) in rats fed a 1 % cholesterol diet. Analysis of serum campesterol : cholesterol and sitosterol : cholesterol suggested that Ca dose-dependently increased intestinal cholesterol absorption (r 0·913, P<0·001, n 18), whereas serum desmosterol : cholesterol and lathosterol : cholesterol indicated that Ca dose-dependently increased endogenous cholesterol synthesis (r 0·691, P=0·003, n 18). Therefore, the decrease of serum LDL-cholesterol appeared to be due to Ca-induced increase in the conversion of cholesterol to bile acids. The increase in Ca intake did not interfere with the beneficial effects of plant sterols on serum total cholesterol, LDL-cholesterol and HDL-cholesterol concentrations. The high-Ca diet with plant sterol supplementation further increased the HDL-cholesterol concentration and HDL : LDL cholesterol. The present findings indicate that the beneficial effects of dietary Ca on the serum lipid profile during a low-fat diet are dose-dependent, and resemble those of bile acid sequestrants. Increased dietary Ca did not impede the lipid-lowering effects of natural plant sterols.
48
Satou, Tadaaki, Naoko Sato, Haruyo Kato, Mana Kawamura, Sanae Watanabe, and Kazuo Koike. "The Effect of Camellia Seed Oil Intake on Lipid Metabolism in Mice." Natural Product Communications 11, no. 4 (April 2016): 1934578X1601100. http://dx.doi.org/10.1177/1934578x1601100424.
Full textAbstract:
Camellia seed oil has mainly been applied to the production of cosmetics, and research into its dietary effects is required. Alterations in lipid metabolism by the intake of camellia seed oil were investigated. Health parameters such as diet intake, weight gain, fat mass, and plasma cholesterol and triglyceride levels were measured in mice fed a high fat diet containing camellia seed oil; comparisons were made to a normal diet and a high fat diet containing either soybean oil or olive oil as controls. No significant differences in weight gain and diet intake were observed between the groups. However, the camellia seed oil diet suppressed epididymal fat weight similarly to the olive oil diet. In total cholesterol and HDL (high density lipoprotein) cholesterol levels, the soybean oil, olive oil and camellia seed oil diet groups showed significant increases compared with the normal diet. However, increases in LDL (low density lipoprotein) cholesterol levels were inhibited by the camellia seed oil diet similarly to the olive oil diet. As the high oleic acid content of camellia seed oil is similar to that of olive oil, it is proposed that its presence mitigated fat accumulation and plasma cholesterol levels.
49
Cobb, Margaret M., and Neil Risch. "Low-density lipoprotein cholesterol responsiveness to diet in normolipidemic subjects." Metabolism 42, no. 1 (January 1993): 7–13. http://dx.doi.org/10.1016/0026-0495(93)90164-j.
Full text
50
Oriakhi, Kelly, and Patrick Uadia. "Hypolipidemic Activity of Tetracarpidium conophorum (African walnut) Seed Oil and Its Mechanism of Action." Planta Medica International Open 07, no. 04 (November 2020): e170-e178. http://dx.doi.org/10.1055/a-1323-0786.
Full textAbstract:
AbstractThe present study was designed to evaluate the hypolipidemic activity of Tetracarpidium conophorum oil and its mechanism(s) of action. The oil was extracted using the Soxhlet method and subjected to column chromatography/spectroscopic techniques. GC-MS analysis was performed on the oil to identify 15 constituents with 9,12,15-octadecatrienoic acid (ω-3 fatty acid or α-linolenic acid) (68%) showing the highest proportion. Isolation and purification of the oil gave three compounds, namely, β-sitosterol, stigmasterol, and stearic acid (octadecanoic acid). Thirty-five rats were used and divided into seven groups for the in vivo hypolipidemic study. Findings from this study showed significant decreases (p<0.05) in total cholesterol, triglycerides, and low-density lipoprotein cholesterol, and an increase in high-density lipoprotein cholesterol in rats fed a normal diet and receiving T. conophorum oil (250 and 500 mg/kg body weight) for 20 days. But there were significant increases (p<0.05) in total cholesterol, triglycerides, low-density lipoprotein cholesterol, creatine kinase, lactate dehydrogenase, aspartate amino transferase, malondialdehyde, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, and C-reactive protein levels with a decline in the low-density lipoprotein cholesterol level in rats fed the high cholesterol diet when compared to those fed a normal diet. However, oral administration of T. conophorum oil and atorvastatin for 20 days resulted in a significant lowering (p<0.05) of triglycerides, low-density lipoprotein cholesterol, creatine kinase, lactate dehydrogenase, aspartate amino transferase, malondialdehyde, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, and C-reactive protein levels with a rise in high-density lipoprotein cholesterol in rats nourished with the high cholesterol diet. The study showed that T. conophorum seed oil possesses hypolipidemic and cardioprotective properties.