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Journal articles on the topic 'Low level laser therapy (lllt)'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Im, Yeong-Gwan, Ji-Yeon Kim, and Byung-Gook Kim. "Low-Level Laser Therapy in Dentistry." Journal of The Korean Dental Association 49, no. 11 (2011): 679–87. http://dx.doi.org/10.22974/jkda.2011.49.11.003.

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Low-level laser therapy (LLLT) is the application of light to pathology to promote tissue regeneration, reduce inflammation, and relieve pain. LLLT has a photochemical effect whereby the light is absorbed and exerts a chemical change. The clinical applications of LLLT include improvement in wound and bone healing processes, control of pain and tooth hypersensitivity, modulation of periodontal inflammation, the prevention and treatment of cancer therapy-induced oral mucositis, management of burning mouth syndrome, and improvement in temporomandibular disorder symptoms. Further research is neede

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Hossein-Khannazer, Nikoo, Mandana Kazem Arki, liasghar Keramatinia, and Mostafa Rezaei-Tavirani. "Low-Level Laser Therapy in the Treatment of Autoimmune Thyroiditis." Journal of Lasers in Medical Sciences 13 (August 24, 2022): e34. http://dx.doi.org/10.34172/jlms.2022.34.

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Introduction: Autoimmune thyroiditis (AIT) is an autoimmune disorder that is characterized by thyroid gland dysfunction. Low-level laser therapy (LLLT), as a safe and non-invasive intervention, has gained much attention in many clinical applications including pain relief, regenerative medicine, and autoimmune.Methods: In this review, we discuss the effect of LLLT on cellular responses and its application in the treatment of AIT. Such keywords as "low-level laser therapy", "photobiomodulation" and "autoimmune thyroiditis" were used to find studies related to laser therapy in AIT in Google Schol

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Momenzadeh, Sirous, Alireza Zali, Zahra Razzaghi, et al. "Efficacy of Low-Level Laser Therapy for the Treatment of Nonspecific Chronic Neck Pain: Low-Level Laser Therapy vs. Sham Laser." Journal of Lasers in Medical Sciences 13 (December 23, 2022): e74. http://dx.doi.org/10.34172/jlms.2022.74.

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Introduction: The most common type of neck pain is chronic nonspecific pain. There are conflicting opinions about the beneficial effects of a low-level laser in reducing chronic nonspecific neck pain. The aim of this study was to evaluate the efficacy of low-level laser therapy (LLLT) for the treatment of non-specific chronic neck pain. Methods: This study was conducted as a prospective randomized clinical trial. Forty-four patients were randomly divided into two groups: (1) Intervention group (n=22): LLLT in the red spectra range with a wavelength of 980 (nm) and a power of 16 (J/cm2 ) was ir

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Reddy, K. Sri Harsha, Ravi Kumar Chittoria, Nishad Kerakada, and Neljo Thomas. "Role of Low Level Laser Therapy in Preventing Keystone Flap Necrosis." New Indian Journal of Surgery 13, no. 2 (2022): 69–72. http://dx.doi.org/10.21088/nijs.0976.4747.13222.3.

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In plastic and reconstructive surgery, skin flaps are widely employed. Large wounds that cannot be closed with normal treatments are treated with skin flap surgery. Skin flap necrosis is a well-known postflap cover issue that can affect cosmetic outcomes and patient satisfaction. Variable occurrence rates and inconsistent related factors have been reported in many retrospective studies of this condition. Despite advances in technology, the rate of flap necrosis remains significant in daily procedures. In this case study, we aim to evaluate the efficacy and safety of Low level laser therapy pre

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Mutia Fadhila Sy and Nelva Karmila Jusuf. "Use of Low Level Laser in Cosmetic Dermatology." Cermin Dunia Kedokteran 51, no. 6 (2024): 352–56. http://dx.doi.org/10.55175/cdk.v51i6.991.

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Low level laser therapy (LLLT) is used in almost all areas of modern medicine, including cosmetic dermatology. LLLT has been beneficial for the treatment of wrinkles, acne vulgaris, hypertrophic scars, hair loss, cellulite, and burns. LLLT can reduce UV damage both as a treatment and as a prophylaxis. In pigmentation disorders such as vitiligo, LLLT can increase pigmentation by stimulating melanocyte proliferation and reducing depigmentation. The non-invasive nature and near absence of side effects of LLLT encourage further research in cosmetic dermatology.

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Alpiah, Dini Nur, and Fenny Nur Alfiyani. "Efektivitas Low-Level Laser Therapy Terhadap Penyembuhan Luka Ulkus Kaki Diabetik : Literature Review." Binawan Student Journal 5, no. 3 (2023): 44–53. http://dx.doi.org/10.54771/bsj.v5i3.969.

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Kejadian diabetes melitus meningkat sesuai dengan usia individu, 15% hingga 25% individu yang menderita diabetes mellitus mengalami kondisi kaki diabetik. Ulkus kaki diabetik merupakan salah satu komplikasi neuropatik atau iskemik yang menyebabkan perubahan biomekanik pada ekstremitas distal. Pemberian low-level laser therapy (LLLT) dapat memberikan kesembuhan luka dikarenakan merangsang pembentukan granulasi yang lebih cepat. Penelitian ini bertujuan untuk mengetahui efektivitas low-level laser therapy (LLLT) terhadap penyembuhan luka dan nyeri pada kondisi pasien ulkus kaki diabetik. Penelit

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Hosmani, Jagadish, Abdullah Alqarni, Hussain Mohammed Almubarak, Master Luqman Mannakandath, and Shaik Mohamed Shamsudeen. "Alleviating Salivary Microbiome Dysbiosis Associated with Dental Malocclusion Utilizing Low-level Laser Therapy." Journal of Multidisciplinary Dental Research 9, no. 2 (2023): 52–55. http://dx.doi.org/10.38138/jmdr/v9i2.23.30.

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Dental malocclusions have been found to disrupt the balance of oral bacteria, contributing to the development of dental caries and periodontal diseases. Utilizing Low-Level Laser Therapy (LLLT) can potentially restore biodiversity and ecological equilibrium in the oral microbiome, promoting optimal oral health. We propose that administering LLLT with a diode laser emitter emitting visible red light at a wavelength of 970±10 nm and power output of 100mW, can have a positive impact on the oral microbiome. With an exposure area of 6cm2 for a duration of 30 seconds per session (4 sessions per week

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Hossein-khannazer, Nikoo, Mandana Kazem Arki, Aliasghar Keramatinia, and Mostafa Rezaei-Tavirani. "Low-Level Laser Therapy for Rheumatoid Arthritis: A Review of Experimental Approaches." Journal of Lasers in Medical Sciences 13 (December 10, 2022): e62. http://dx.doi.org/10.34172/jlms.2022.62.

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Introduction: Rheumatoid arthritis (RA) is an inflammatory and autoimmune disorder that is characterized by joint inflammation, pain, physical disability, and morning stiffness. In the present study, the effect of low-level laser therapy (LLLT) on RA was reviewed. Methods: "Low-level laser therapy", "rheumatoid arthritis disease", and "photobiomodulation" keywords were searched in Google Scholar, PubMed, and Medline. Results: A literature survey led to a discussion about the immunology of the RA, laser therapy, mechanism of LLLT action, and anti-inflammatory and immunomodulatory properties of

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Rola, Piotr, Szymon Włodarczak, Maciej Lesiak, Adrian Doroszko, and Adrian Włodarczak. "Changes in Cell Biology under the Influence of Low-Level Laser Therapy." Photonics 9, no. 7 (2022): 502. http://dx.doi.org/10.3390/photonics9070502.

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Low-level laser therapy (LLLT) has become an important part of the therapeutic process in various diseases. However, despite the broad use of LLLT in everyday clinical practice, the full impact of LLLT on cell life processes has not been fully understood. This paper presents the current state of knowledge concerning the mechanisms of action of LLLT on cells. A better understanding of the molecular processes occurring within the cell after laser irradiation may result in introducing numerous novel clinical applications of LLLT and potentially increases the safety profile of this therapy.

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Kushibiki, Toshihiro, Takeshi Hirasawa, Shinpei Okawa, and Miya Ishihara. "Low Reactive Level Laser Therapy for Mesenchymal Stromal Cells Therapies." Stem Cells International 2015 (2015): 1–12. http://dx.doi.org/10.1155/2015/974864.

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Low reactive level laser therapy (LLLT) is mainly focused on the activation of intracellular or extracellular chromophore and the initiation of cellular signaling by using low power lasers. Over the past forty years, it was realized that the laser therapy had the potential to improve wound healing and reduce pain and inflammation. In recent years, the term LLLT has become widely recognized in the field of regenerative medicine. In this review, we will describe the mechanisms of action of LLLT at a cellular level and introduce the application to mesenchymal stem cells and mesenchymal stromal ce

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H.K., Sudhanva, Chittoria R.K., Pandey S., Mohapatra D.P., Friji M.T., and Dinesh K.S. "Efficacy of Low Level Laser Therapy (LLLT) in Burn Wound Management." New Indian Journal of Surgery 8, no. 2 (2017): 151–53. http://dx.doi.org/10.21088/nijs.0976.4747.8217.25.

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H.K., Sudhanva, Chittoria R.K., Preethitha B., et al. "Role of Low Level Laser Therapy (LLLT) in Pressure Sore Management." Indian Journal of Medical and Health Sciences 4, no. 1 (2017): 33–35. http://dx.doi.org/10.21088/ijmhs.2347.9981.4117.6.

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There are situations when patients are unfit for anesthesia or unwilling for surgery when plastic surgeon has to make the wound heal by secondary intention.In such situations adjunct therapies like Low Level Laser (LLL) helps in promoting wound healing. LLL are lasers with a wave-length between 600 and 1000 nanometers and power from 5 to 500 Mw. The bio-stimulatory properties of LLL has been found to accelerate wound healing, tissue repair and regeneration. This study highlights the application of LLL in a 40-year-old male with multiple pressure sores unfit foranesthesia.

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Ayyildiz, Simel, Faruk Emir, and Cem Sahin. "Evaluation of Low-Level Laser Therapy in TMD Patients." Case Reports in Dentistry 2015 (2015): 1–6. http://dx.doi.org/10.1155/2015/424213.

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Light amplification by stimulated emission of radiation (laser) is one of the most recent treatment modalities in dentistry. Low-level laser therapy (LLLT) is suggested to have biostimulating and analgesic effects through direct irradiation without causing thermal response. There are few studies that have investigated the efficacy of laser therapy in temporomandibular disorders (TMD), especially in reduced mouth opening. The case report here evaluates performance of LLLT with a diode laser for temporomandibular clicking and postoperative findings were evaluated in two cases of TMD patients. Fi

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Berni, Micaela, Alice Maria Brancato, Camilla Torriani, et al. "The Role of Low-Level Laser Therapy in Bone Healing: Systematic Review." International Journal of Molecular Sciences 24, no. 8 (2023): 7094. http://dx.doi.org/10.3390/ijms24087094.

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Low-level laser therapy (LLLT) is a treatment that is increasingly used in orthopedics practices. In vivo and in vitro studies have shown that low-level laser therapy (LLLT) promotes angiogenesis, fracture healing and osteogenic differentiation of stem cells. However, the underlying mechanisms during bone formation remain largely unknown. Factors such as wavelength, energy density, irradiation and frequency of LLLT can influence the cellular mechanisms. Moreover, the effects of LLLT are different according to cell types treated. This review aims to summarize the current knowledge of the molecu

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Lin, Yi-Yuan, Shin-Yi Lee, and Yu-Jung Cheng. "Low-Level Laser Therapy Induces Melanoma Tumor Growth by Promoting Angiogenesis." Life 13, no. 2 (2023): 320. http://dx.doi.org/10.3390/life13020320.

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The effects of low-level laser therapy (LLLT) on tumor growth are inconsistent. In this study, we investigated the effects of LLLT on melanoma tumor growth and angiogenesis. C57/BL6 mice were challenged with B16F10 melanoma cells and treated with LLLT for 5 consecutive days; untreated mice were used as controls. Tumor weight, angiogenesis, immunohistochemistry, and protein levels were compared between the treated and untreated mice. In an in vitro experiment, B16F10 cells were treated with LLLT. Proteins were extracted and subjected to Western blot analysis for analyzing signaling pathways. Co

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Goodman, Shawn S., Ruth A. Bentler, Andrew Dittberner, and Ian B. Mertes. "The Effect of Low-Level Laser Therapy on Hearing." ISRN Otolaryngology 2013 (April 23, 2013): 1–9. http://dx.doi.org/10.1155/2013/916370.

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One purported use of low-level laser therapy (LLLT) is to promote healing in damaged cells. The effects of LLLT on hearing loss and tinnitus have received some study, but results have been equivocal. The purpose of this study was to determine if LLLT improved hearing, speech understanding, and/or cochlear function in adults with hearing loss. Using a randomized, double-blind, placebo-controlled design, subjects were assigned to a treatment, placebo, or control group. The treatment group was given LLLT, which consisted of shining low-level lasers onto the outer ear, head, and neck. Each laser t

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Das, Neelam. "A Biostimulation Therapy in Periodontics: An Evidence‑Based Review." Perio J 6, no. 1 (2022): 1–11. http://dx.doi.org/10.26810/perioj.2022.a1.

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Low-level laser therapy (LLLT) is a light source treatment that generates light of a single wavelength. Low-level lasers do not cause temperature elevation within tissue, but rather produce their effects through photobiostimulation. Low-level lasers (LLL) do not cut or ablate tissue. Low-level laser therapy devices include gallium-aluminum-arsenide (Ga-Al-As) infrared semiconductors and helium-neon (He-Ne) lasers. The output powers range from 50 to 500 mW with wavelengths in the red and near infrared of the electromagnetic spectrum, from 630 to 980 nm, with pulsed or continuous-wave emission.

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Moskvin, Sergey Vladimirovich. "Low-Level Laser Therapy for Herpesvirus Infections: A Narrative Literature Review." Journal of Lasers in Medical Sciences 12, no. 1 (2021): e38-e38. http://dx.doi.org/10.34172/jlms.2021.38.

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Introduction: Herpesvirus infection has a variety of clinical forms and is extremely widespread in the world while existing treatment methods are not always quite effective. The search for new treatment modalities is a relevant problem and numerous studies show the therapeutic effect of low-level laser therapy (LLLT) on different herpesvirus types. Methods: The mechanisms of laser light action and the impact of LLLT on the pathological pathways of herpes infections are described. A narrative review of the relevant papers is conducted. Results: The reviewed studies confirm that LLLT is a potent

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Ribeiro, Tatiana Pinto, Simone Bustamante Nascimento, Claúdia Alessandra Cardoso, Raduan Hage, Janete Dias Almeida, and Emilia Angela Loschiavo Arisawa. "Low-Level Laser Therapy and Calcitonin in Bone Repair: Densitometric Analysis." International Journal of Photoenergy 2012 (2012): 1–5. http://dx.doi.org/10.1155/2012/829587.

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The aim of this work was to evaluate the association of low-level laser therapy (LLLT, 830 nm) and calcitonin in bone repair considering that bone healing remains a challenge to health professionals. Calcitonin has antiosteoclastic action and LLLT is a treatment that uses low-level lasers or light-emitting diodes to alter cellular function. Both are used to improve bone healing. Densitometry is a clinical noninvasive valuable tool used to evaluate bone mineral density (BMD). Sixty male rats were submitted to bone defect with a trephine bur, randomly divided into four groups of 15 animals each:

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Barger, Brenna K., Adam M. Bisges, Derek B. Fox, and Bryan Torres. "Low-Level Laser Therapy for Osteoarthritis Treatment in Dogs at Missouri Veterinary Practice." Journal of the American Animal Hospital Association 56, no. 3 (2020): 139–45. http://dx.doi.org/10.5326/jaaha-ms-6851.

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Abstract A qualitative survey was electronically distributed to practicing veterinarians in the state of Missouri to evaluate the frequency of use and economic impact of low-level laser therapy (LLLT) for the treatment of osteoarthritis (OA) in dogs in Missouri. The survey response rate was 10% (89/867). Approximately half (43%) of respondents had LLLT units, of which all used LLLT for OA treatment in dogs. In respondents without LLLT units, 20% referred patients for LLLT OA treatment. Training was most often obtained in-house by a representative of the LLLT unit manufacturer (76%). Treatment

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Tsuchiya, Kazuaki, Takashi Harada, Nobuyuki Ushigome, et al. "LOW LEVEL LASER THERAPY (LLLT) FOR CEREBRAL PALSY." LASER THERAPY 17, no. 1 (2008): 29–33. http://dx.doi.org/10.5978/islsm.17.29.

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Wolbarsht, Myron L. "Low‐level laser therapy (LLLT) and safety considerations." Journal of Laser Applications 6, no. 3 (1994): 170–72. http://dx.doi.org/10.2351/1.4745354.

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Godine, Richard L. "Low Level Laser Therapy (LLLT) in Veterinary Medicine." Photomedicine and Laser Surgery 32, no. 1 (2014): 1–2. http://dx.doi.org/10.1089/pho.2013.9867.

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Rosenkrans, Ashley, Carson Freeman, Erin L. Oberhaus, Palika Dias Morse, and Charles Rosenkrans. "121 Physiological effects of low level laser therapy on exercised horses." Journal of Animal Science 98, Supplement_2 (2020): 34. http://dx.doi.org/10.1093/jas/skz397.077.

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Abstract Low level laser therapy (LLLT) is a form of phototherapy, which may stimulate healing of injuries and lesions from exercise. Our objective was to determine effects of LLLT before or after exercise on equine serum concentrations of cortisol, lactate, and cytochrome P450 (CYP) inhibition. Twelve quarter horses were randomly assigned to one of three groups: (A) received no laser therapy, (B) received six minutes of laser therapy before exercise, and (C) received six minutes of laser therapy after exercise. Laser (635 nm) treatment was with a class II handheld low-level laser with constan

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Rosenkrans, Ashley, Carson Freeman, Erin L. Oberhaus, Palika Dias Morse, and Charles Rosenkrans. "122 Physiological effects of low level laser therapy on exercised horses." Journal of Animal Science 98, Supplement_2 (2020): 80–81. http://dx.doi.org/10.1093/jas/skz397.189.

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Abstract Low level laser therapy (LLLT) is a form of phototherapy which may stimulate healing of injuries and lesions from exercise. Our objective was to determine effects of LLLT before or after exercise on equine serum concentrations of cortisol, lactate, and cytochrome P450 (CYP) inhibition. Twelve quarter horses were randomly assigned to one of three groups: (A) received no laser therapy, (B) received six minutes of laser therapy before exercise, and (C) received six minutes of laser therapy after exercise. Laser (635 nm) treatment was with a class II handheld low-level laser with constant

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Adiastuti, Endah Parmadiati, Kamila Putri Yasmin, Alya Zahra Indah, and Rima Rohita Zulfa Dhea. "Effectiveness of low-level laser therapy on oral wound healing: A scoping review." World Journal of Advanced Research and Reviews 24, no. 2 (2024): 2351–61. https://doi.org/10.5281/zenodo.15123558.

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Low-level laser therapy (LLLT) has gained attention as a non-invasive approach for enhancing wound healing across various clinical applications. This review evaluates the effectiveness of LLLT on healing rates, pain reduction, and functional improvement across different conditions, including oral ulcers, aphthous stomatitis, diabetic ulcers, knee osteoarthritis (KOA), and bone healing with platelet-rich plasma (PRP). LLLT demonstrated high effectiveness in soft-tissue-related conditions, achieving notable healing rates (88% in aphthous stomatitis) and substantial pain relief (around 80% in ora

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Hossein-khannazer, Nikoo, Mandana Kazem Arki, Aliasghar Keramatinia, and Mostafa Rezaei-Tavirani. "The Role of Low-Level Laser Therapy in the Treatment of Multiple Sclerosis: A Review Study." Journal of Lasers in Medical Sciences 12, no. 1 (2021): e88-e88. http://dx.doi.org/10.34172/jlms.2021.88.

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Introduction: Multiple sclerosis (MS) is an autoimmune disease. Inflammatory cells, cytokines and chemokines play a major role in the pathogenesis of the disease. Low-level laser therapy (LLLT) as a photobiostimulation approach could affect a wide range of cellular responses. LLLT inhibits the inflammatory signaling pathway, improves cell viability, inhibits apoptosis, modulates immune responses and induces the production of growth factors. Methods: In this review, we discuss the effect of LLLT on cellular responses and its application in the treatment of MS. Such keywords as "low-level laser

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Adaki, Raghavendra, Shridevi Adaki, Amol Karagir, and Jivanasha Agrawal. "Effect of Low-Level Laser Therapy on Osseointegration: A Comprehensive Review." Journal of Neonatal Surgery 14, no. 18S (2025): 801–4. https://doi.org/10.63682/jns.v14i18s.5262.

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Low-Level Laser Therapy (LLLT), also known as photobiomodulation, has garnered attention in the field of implant dentistry for its potential to enhance osseointegration—the direct structural and functional connection between living bone and the surface of a load-bearing implant. This review aims to critically evaluate the current evidence on the efficacy of LLLT in promoting bone regeneration and improving the integration of dental implants with surrounding bone tissue. By analysing both preclinical and clinical studies, we seek to elucidate the underlying mechanisms of LLLT and its practical

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Kuan, Yi-Chun. "Low-Level Laser Therapy for Fibromyalgia: A Systematic Review and Meta-Analysis." Pain Physician 3, no. 22;3 (2019): 241–54. http://dx.doi.org/10.36076/ppj/2019.22.241.

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Background: Fibromyalgia is a chronic disorder characterized by widespread pain and tenderness. Low-level laser therapy (LLLT), an emerging nonpharmacological treatment, has been used for relieving musculoskeletal or neuropathic pain. Objective: The objective of this review and meta-analysis was to determine the efficacy of LLLT on patients with fibromyalgia. Study Design: This study involved systematic review and quantitative meta-analysis of published randomized controlled trials (RCTs). Setting: This study examined all RCTs evaluating the effect of LLLT on fibromyalgia. Methods: We performe

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Caprioglio, C., G. Olivi, and M. D. Genovese. "Lasers in dental traumatology and low level laser therapy (LLLT)." European Archives of Paediatric Dentistry 12, no. 2 (2011): 79–84. http://dx.doi.org/10.1007/bf03262783.

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Basso, Fernanda G., Camila F. Oliveira, Amanda Fontana, et al. "In Vitro effect of low-level laser therapy on typical oral microbial biofilms." Brazilian Dental Journal 22, no. 6 (2011): 502–10. http://dx.doi.org/10.1590/s0103-64402011000600011.

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The aim of this study was to evaluate the effect of specific parameters of low-level laser therapy (LLLT) on biofilms formed by Streptococcus mutans, Candida albicans or an association of both species. Single and dual-species biofilms - SSB and DSB - were exposed to laser doses of 5, 10 or 20 J/cm2 from a near infrared InGaAsP diode laser prototype (LASERTable; 780 ± 3 nm, 0.04 W). After irradiation, the analysis of biobilm viability (MTT assay), biofilm growth (cfu/mL) and cell morphology (SEM) showed that LLLT reduced cell viability as well as the growth of biofilms. The response of S. mutan

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Ali, Ketabi Mohammad, and Mojtaba Sabzijat. "Effect of low-level laser on controlling temporomandibular disorders." Revista Latinoamericana de Hipertensión V15, no. 2 (2020): págs 138–143. https://doi.org/10.5281/zenodo.4074408.

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<strong>Abstract</strong> Background: Temporomandibular disorders (TMD) are characterized with associated headache and facial pains to induce common complaints in the temporomandibular joint, ears, and masticatory muscles, as well as both or one side of the jaw pain after biting down. present work was designed to study on the efficacy of low-level laser therapy (LLLT) for controlling temporomandibular disorders. Materials and Method: Based on the previous studies, 40 patients were selected based on the protocol for evaluation tools of temporomandibular disorders. All subjects were exposed to L

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Abdelbasset, Walid Kamal, Gopal Nambi, Saud F. Alsubaie, et al. "A Randomized Comparative Study between High-Intensity and Low-Level Laser Therapy in the Treatment of Chronic Nonspecific Low Back Pain." Evidence-Based Complementary and Alternative Medicine 2020 (October 28, 2020): 1–6. http://dx.doi.org/10.1155/2020/1350281.

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Objectives. Chronic nonspecific low back pain (chronic nsLBP) is one of the most common musculoskeletal disorders leading to disabilities and physical inactivity. Laser therapy was used in chronic nsLBP treatment; however, no previous studies have assessed the impacts of high-intensity laser therapy (HILT) versus low-level laser therapy (LLLT) on chronic nsLBP. This study compared the effects of HILT versus LLLT on individuals suffering from chronic nsLBP. Methods. The study was a randomized control trial. Sixty individuals with chronic nsLBP were enrolled in this study between May and Novembe

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Lee, John Muzi, Regan M. Look, Crystal Turner, et al. "Low-level laser therapy for chemotherapy-induced peripheral neuropathy." Journal of Clinical Oncology 30, no. 15_suppl (2012): 9019. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.9019.

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9019 Background: Chemotherapy induced peripheral neuropathy (CIPN) is a common and serious side effect from chemotherapy agents. Low-level laser light therapy (LLLT) devices were approved in 2002 for pain management. Studies suggest a local release of serotonin, increased mitochondrial ATP production, or anti-inflammatory effects as a mechanism of action. We then questioned whether LLLT would show efficacy in mitigating symptoms caused by CIPN. Methods: In a single center prospective randomized trial, participants were randomized to receive either treatment with LLLT twice a week for 8 weeks o

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Astri, Setia Wati, Nyoman Murdhana, Nury Nusdwinuringtyas, Aria Kekalih, Peggy Sunarjo, and Ferius Soewito. "The Comparison Of The Low-Level Laser Therapy And High Intensity Laser Therapy On Pain And Functional Ability In Knee Osteoarthritis." Journal Of The Indonesian Medical Association 72, no. 6 (2023): 275–83. http://dx.doi.org/10.47830/jinma-vol.72.6-2022-826.

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Introduction: Osteoarthritis (OA) of the knee causes disability due to pain and will affect the functional ability to walk. Low-Level Laser Therapy (LLLT) has been shown to reduce pain in knee OA, while High Intensity Laser Therapy (HILT) is able to reach deeper joint areas. Method: This study aimed to compare the effect differences between LLLT and HILT on pain and functional capacity in knee OA. Methods: This is a double-blind randomized controlled trial with 61 subjects randomized into LLLT (n=31) and HILT (n=30) groups. All the subjects were knee OA patient with Visual Analog Scale (

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de Oliveira, Milene Castilhos, Gabriel Francisco Krueger, Juliana Tomaz Sganzerla, et al. "Effect of Radiotherapy and Low-Level Laser Therapy on Circulating Blood Cells of Rats." Journal of Lasers in Medical Sciences 12, no. 1 (2021): e45-e45. http://dx.doi.org/10.34172/jlms.2021.45.

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Introduction: This study aimed to investigate the effect of low-level laser therapy (LLLT) on the blood cell count when applied to parotid glands of rats irradiated by volumetric modular arc therapy (VMAT). Methods: Thirty-two adult male Wistar rats were used in this study. Samples were randomly assigned to three groups: control group (CG, n = 8), immediate laser group (24 hours) (ILG, n=12), and late laser group (120 hours) (LLG, n=12). The two laser groups were previously subjected to VMAT radiotherapy in a single dose of 12 Gy. LLLT with an AsGaAl laser (660 nm, 100 mW) was applied at three

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Adiastuti Endah Parmadiati, Yasmin Kamila Putri, Indah Alya Zahra, and Dhea Rima Rohita Zulfa. "Effectiveness of low-level laser therapy on oral wound healing: A scoping review." World Journal of Advanced Research and Reviews 24, no. 2 (2024): 2351–61. https://doi.org/10.30574/wjarr.2024.24.2.3488.

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Low-level laser therapy (LLLT) has gained attention as a non-invasive approach for enhancing wound healing across various clinical applications. This review evaluates the effectiveness of LLLT on healing rates, pain reduction, and functional improvement across different conditions, including oral ulcers, aphthous stomatitis, diabetic ulcers, knee osteoarthritis (KOA), and bone healing with platelet-rich plasma (PRP). LLLT demonstrated high effectiveness in soft-tissue-related conditions, achieving notable healing rates (88% in aphthous stomatitis) and substantial pain relief (around 80% in ora

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Ahmed, Samith. "LOW LEVEL LASER THERAPY (LLLT) - AN INTRODUCTION TO COLD LASER." Journal of Evolution of Medical and Dental Sciences 2, no. 39 (2013): 7414–17. http://dx.doi.org/10.14260/jemds/1316.

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Glazov, Gregory, Michael Yelland, and Jon Emery. "Low-Level Laser Therapy for Chronic Non-Specific Low Back Pain: A Meta-Analysis of Randomised Controlled Trials." Acupuncture in Medicine 34, no. 5 (2016): 328–41. http://dx.doi.org/10.1136/acupmed-2015-011036.

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Objective The efficacy of low-level laser treatment (LLLT) for chronic back pain remains controversial due to insufficient trial data. We aimed to conduct an updated review to determine if LLLT (including laser acupuncture) has specific benefits in chronic non-specific low back pain (CNLBP). Methods Electronic databases were searched for randomised trials using sham controls and blinded assessment examining the intervention of LLLT in adults with CNLBP. Primary outcomes were pain and global assessment of improvement with up to short-term follow-up. Secondary outcomes were disability, range of

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Ren, Jun, Hui Wang, Jiang Xu, Mohd Isa, Mohd Rahman, and Yi Wang. "Low-Level Laser Therapy Improves Visual Function in Occult Macular Dystrophy." International Journal of Ophthalmology & Visual Science 10, no. 2 (2025): 35–41. https://doi.org/10.11648/j.ijovs.20251002.12.

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&lt;i&gt;Background&lt;/i&gt;: Occult macular dystrophy (OMD) is a binocular hereditable macular disease caused by Retinitis pigmentosa 1-like 1(RP1L1) gene variation. Currently, there is no effective treatment for OMD. Low-level laser therapy (LLLT) is an innovative treatment for ophthalmological conditions by stimulate mitochondrial function. In this paper, we report a case of OMD and the effects of LLLT on this patient. &lt;i&gt;Case Presentation&lt;/i&gt;: A 20-year-old man was diagnosed with OMD by genetic diagnosis. At presentation, the best corrected visu

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Ahmad, Syed Ansar, Shamimul Hasan, Shazina Saeed, Ateeba Khan, and Munna Khan. "Low-level laser therapy in temporomandibular joint disorders: a systematic review." Journal of Medicine and Life 14, no. 2 (2021): 148–64. http://dx.doi.org/10.25122/jml-2020-0169.

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Temporomandibular joint disorders (TMDs) encompass a wide array of ailments affecting the temporomandibular joint (TMJ), muscles of mastication, and the allied structural framework. Myofascial pain, internal derangement of the joint, and degenerative joint diseases constitute the majority of TMDs. TMDs usually have a multifactorial etiology, and treatment modalities range from conservative therapies to surgical interventions. Low-level laser therapy (LLLT) has evolved as an efficient non-invasive therapeutic modality in TMDs. Previously conducted systematic reviews and meta-analyses have shown

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Casillas Santana, Miguel Angel Angel, María Fernanda García Vega, Juan Eduardo Gomez Vázquez, Olin Guadalupe Montero Jiménez, Daniela Orozco Jiménez, and Jair Rodríguez Zarate. "Clinical and experimental knowledge of photobiomodulation in accelerated orthodontics: a review." Revista Estomatología 28, no. 1 (2020): 18–25. http://dx.doi.org/10.25100/re.v28i1.10548.

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In recent years, there has been an increasing interest in finding a noninvasive method to induce the acceleration of dental movement, methods such as low intensity vibrations, pulsed electromagnetic fields, and low-level laser therapy (LLLT). There have been multiple studies on the efficacy of LLLT in animal models, in vitro and in patients without conclusive results. Objective: Evaluate the state of the art on the use of LLLT to increase the rate of the orthodontic tooth movement to create a concise reference guide of the different laser and protocols available. Materials and Methods: We sear

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Pereira de Godoy, Jose Maria, Lívia Maria Pereira de Godoy, Esteban Fortuny Pacheco, and Maria de Fátima Guerreiro Godoy. "The initial impact of low-level laser therapy on a traumatic leg ulcer." Our Dermatology Online 12, no. 2 (2021): 171–73. http://dx.doi.org/10.7241/ourd.20212.17.

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Low-level laser therapy (LLLT) has been used as an effective, safe, and noninvasive treatment for wound healing. This paper reports the case of a 78-year-old female who had suffered trauma to the anterior tibial region of the leg. The injury continued to worsen for a month, along with an increase in pain, even with medical treatment involving antibiotics and conventional bandaging. An examination revealed a hyperemic injury with secretions, and LLLT was proposed, with red laser at 3 J and 660 mW and for a 25 s exposure time. The patient returned after four days reporting a substantial improvem

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Choi, Binhye, Mun Seog Chang, Ha Young Kim, Jae-Woo Park, Bongha Ryu, and Jinsung Kim. "Effects of Low Level Laser Therapy on Ovalbumin-Induced Mouse Model of Allergic Rhinitis." Evidence-Based Complementary and Alternative Medicine 2013 (2013): 1–8. http://dx.doi.org/10.1155/2013/753829.

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Introduction. This study was designed to investigate the effects of low level laser therapy (LLLT) on experimental allergic rhinitis (AR) models induced by ovalbumin.Materials and Methods. AR was induced by 1% ovalbumin in mice. Twenty-four mice were divided into 4 groups: normal, control, low, and high dose irradiation. Low and high dose LLLT were irradiated once a day for 7 days. Total IgE, cytokines concentrations (IL-4 and IFN-γ), and thymus and activation regulated chemokine (TARC) were measured. Histological changes in the nasal mucosal tissue by laser irradiation were examined.Results.

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Leite, Priscila, Nicole Melo, Pâmela Silva, Robinsom Montenegro, Paulo Bonan, and André Batista. "Low-level laser therapy for temporomandibular disorders (tmd) treatment: a systematic review of randomized trials." Journal of Research in Dentistry 2, no. 5 (2014): 376. http://dx.doi.org/10.19177/jrd.v2e52014376-387.

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AIM: Conducting a systematic review of randomized clinical trials focusing on the efficacy of LLLT on pain control in patients with TMD, diagnosed by the Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD). MATERIAL AND METHODS: Search was performed at PubMed/MEDLINE database with the terms: (1) “Laser AND temporomandibular disorders”; (2) “Laser AND temporomandibular disorders AND RDC/TMD”; (3) “Low-level laser therapy AND temporomandibular disorders”; (4) “Low-level laser therapy AND temporomandibular disorders AND RDC/TMD”; (5) “Low-level laser therapy AND temporomandibul

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Bereșescu, Gabriela, Monica Monea, Bianca Porca, Alina Cocan, and Adriana Maria Monea. "Effects of Low Level Laser Therapy on Bone Regeneration of Intrabony Defects." Key Engineering Materials 638 (March 2015): 151–54. http://dx.doi.org/10.4028/www.scientific.net/kem.638.151.

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The aim of this study is to assess the histological efficiency of low level laser therapy (LLLT) with respect to the acceleration of bone regeneration after surgical treatment of intrabony defects. Twenty patients with intrabony defects, aged between 20-45, non-smokers, good health condition present at the time of the surgery, were randomly divided in two groups, control, ten parients, and test group, ten patients. Informed consent was obtained. Each patient presented at least one periodontal defect treated by bone allograft. The test group received postsurgical treatment with low lever laser

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Lanferdini, Fábio J., Rodrigo R. Bini, Bruno M. Baroni, Kelli D. Klein, Felipe P. Carpes, and Marco A. Vaz. "Improvement of Performance and Reduction of Fatigue With Low-Level Laser Therapy in Competitive Cyclists." International Journal of Sports Physiology and Performance 13, no. 1 (2018): 14–22. http://dx.doi.org/10.1123/ijspp.2016-0187.

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Evidence indicates that low-level laser therapy (LLLT) minimizes fatigue effects on muscle performance. However, the ideal LLLT dosage to improve athletes’performance during sports activities such as cycling is still unclear. Therefore, the goal of this study was to investigate the effects of different LLLT dosages on cyclists’performance in time-to-exhaustion tests. In addition, the effects of LLLT on the frequency content of the EMG signals to assess fatigue mechanisms were examined. Twenty male competitive cyclists participated in a crossover, randomized, double-blind, placebo-controlled tr

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Chittoria, Ravi Kumar, Jackson Nuli, and Barath Kumar Singh P. "Role of low-level laser therapy (LLLT) on skin graft donor site." IP Journal of Surgery and Allied Sciences 4, no. 3 (2022): 106–8. http://dx.doi.org/10.18231/j.jsas.2022.020.

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The management of wound starts from acute stage and extends up to augmentation of scar tissue remodeling. The clinician seeks to optimize wound care to promote healing. Many authors of clinical studies have reported the benefits of LLLT on tissue healing. We report the use of Low-level Laser Therapy (LLLT) on skin graft donor site as a regenerative therapy for augmenting the wound healing.

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Abid Ali, Shawqi J., Isra’a F. Ja’afar, and Zeki N. Hasan. "Effectiveness of Low Level Laser in the Treatment of Carpal Tunnel Syndrome." Journal of the Faculty of Medicine Baghdad 54, no. 3 (2012): 234–38. http://dx.doi.org/10.32007/jfacmedbagdad.543725.

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Background: Carpal tunnel syndrome (CTS) is one of common peripheral nerve disorder which involves an entrapment neuropathy of the median nerve at the wrist which occurs either due to primary idiopathic cause or secondary to systemic causes. The diagnosis of CTS is clinical and supported by neurophysiological analysis. Surgical intervention is the main treatment modality.Objective: The aim of the present study is to evaluate the effectiveness of low level laser therapy (LLLT) to treat mild – moderate CTS cases.Pateients and methods: The study involves 60 symptomatic patients complaining of CTS

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Liu, Xiao-Guang, Lin Cheng, and Ji-Mei Song. "Effects of Low-Level Laser Therapy and Eccentric Exercises in the Treatment of Patellar Tendinopathy." International Journal of Photoenergy 2014 (2014): 1–6. http://dx.doi.org/10.1155/2014/785386.

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The study aims to investigate if low-level laser therapy (LLLT) combined with eccentric exercises could more effectively treat patellar tendinopathy than LLLT alone and eccentric exercises alone. Twenty-one patients with patellar tendinopathy were randomized to three groups: laser alone, exercise alone, or laser plus exercise, with seven in each group. Laser irradiations were administered at the inferior pole of the patella and the two acupoints of Extra 36 (Xiyan) with the intensity of 1592 mW/cm2. Eccentric training program consisted of three sets of 15 repetitions of unilateral squat on lev

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