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1

Huang, Ying-Ying, Aaron C. H. Chen, James D. Carroll, and Michael R. Hamblin. "Biphasic Dose Response in Low Level Light Therapy." Dose-Response 7, no. 4 (2009): dose—response.0. http://dx.doi.org/10.2203/dose-response.09-027.hamblin.

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2

Agrawal, Tanupriya, Gaurav K. Gupta, Vikrant Rai, James D. Carroll, and Michael R. Hamblin. "Pre-Conditioning with Low-Level Laser (Light) Therapy: Light before the Storm." Dose-Response 12, no. 4 (2014): dose—response.1. http://dx.doi.org/10.2203/dose-response.14-032.agrawal.

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Pre-conditioning by ischemia, hyperthermia, hypothermia, hyperbaric oxygen (and numerous other modalities) is a rapidly growing area of investigation that is used in pathological conditions where tissue damage may be expected. The damage caused by surgery, heart attack, or stroke can be mitigated by pre-treating the local or distant tissue with low levels of a stress-inducing stimulus, that can induce a protective response against subsequent major damage. Low-level laser (light) therapy (LLLT) has been used for nearly 50 years to enhance tissue healing and to relieve pain, inflammation and swe
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3

Huang, Ying-Ying, Sulbha K. Sharma, James Carroll, and Michael R. Hamblin. "Biphasic Dose Response in Low Level Light Therapy – an Update." Dose-Response 9, no. 4 (2011): dose—response.1. http://dx.doi.org/10.2203/dose-response.11-009.hamblin.

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4

Fleming, Colin J., Elizabeth L. C. Salisbury, Paul Kirwan, Dorothy M. Painter, and Ross StC Bametson. "Chrysiasis after low-dose gold and UV light exposure." Journal of the American Academy of Dermatology 34, no. 2 (1996): 349–51. http://dx.doi.org/10.1016/s0190-9622(07)80006-5.

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5

Vinçon, Britta, Claudia Geisler, and Alexander Egner. "Pixel hopping enables fast STED nanoscopy at low light dose." Optics Express 28, no. 4 (2020): 4516. http://dx.doi.org/10.1364/oe.385174.

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6

Furukawa, Fukumi, Ken-Ichi Toda, and Manabu Fukumoto. "Low dose UVB light irradiation augments proliferation of cultured keratinocytes." Journal of Dermatological Science 1, no. 5 (1990): 396. http://dx.doi.org/10.1016/0923-1811(90)90698-d.

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7

Kastritis, Efstathios, Evangelos Terpos, Maria Roussou, et al. "A phase 1/2 study of lenalidomide with low-dose oral cyclophosphamide and low-dose dexamethasone (RdC) in AL amyloidosis." Blood 119, no. 23 (2012): 5384–90. http://dx.doi.org/10.1182/blood-2011-12-396903.

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Abstract In this phase 1/2 study, we explored the feasibility and activity of an oral regimen of lenalidomide with low-dose dexamethasone and low-dose oral cyclophosphamide (RdC) in patients with primary systemic light chain amyloidosis. RdC was given for up to 12 cycles in prespecified cohorts at escalated doses: 13 patients were treated in phase 1 and 24 in phase 2; 65% were previously untreated, and most had renal and/or cardiac involvement and elevated cardiac biomarkers. Lenalidomide 15 mg/d and cyclophosphamide 100 mg/d were further evaluated in phase 2. On intention to treat, 20 (55%) p
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8

Hishida, Takashi, Yoshino Kubota, Antony M. Carr, and Hiroshi Iwasaki. "RAD6–RAD18–RAD5-pathway-dependent tolerance to chronic low-dose ultraviolet light." Nature 457, no. 7229 (2008): 612–15. http://dx.doi.org/10.1038/nature07580.

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9

Moser, Felipe, Vojtěch Pražák, Valerie Mordhorst, et al. "Cryo-SOFI enabling low-dose super-resolution correlative light and electron cryo-microscopy." Proceedings of the National Academy of Sciences 116, no. 11 (2019): 4804–9. http://dx.doi.org/10.1073/pnas.1810690116.

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Correlative light and electron cryo-microscopy (cryo-CLEM) combines information from the specific labeling of fluorescence cryo-microscopy (cryo-FM) with the high resolution in environmental context of electron cryo-microscopy (cryo-EM). Exploiting super-resolution methods for cryo-FM is advantageous, as it enables the identification of rare events within the environmental background of cryo-EM at a sensitivity and resolution beyond that of conventional methods. However, due to the need for relatively high laser intensities, current super-resolution cryo-CLEM methods require cryo-protectants o
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10

Wong, Darice Y., Thanmayi Ranganath, and Andrea M. Kasko. "Low-Dose, Long-Wave UV Light Does Not Affect Gene Expression of Human Mesenchymal Stem Cells." PLOS ONE 10, no. 9 (2015): e0139307. http://dx.doi.org/10.1371/journal.pone.0139307.

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11

Hardeland, Rüdiger. "Divergent Importance of Chronobiological Considerations in High- and Low-dose Melatonin Therapies." Diseases 9, no. 1 (2021): 18. http://dx.doi.org/10.3390/diseases9010018.

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Melatonin has been used preclinically and clinically for different purposes. Some applications are related to readjustment of circadian oscillators, others use doses that exceed the saturation of melatonin receptors MT1 and MT2 and are unsuitable for chronobiological purposes. Conditions are outlined for appropriately applying melatonin as a chronobiotic or for protective actions at elevated levels. Circadian readjustments require doses in the lower mg range, according to receptor affinities. However, this needs consideration of the phase response curve, which contains a silent zone, a delay p
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12

Liu, Qun, and Wayne Hendrickson. "Native-SAD Phasing at Synchrotrons: A Low-dose and High-redundancy Strategy." Acta Crystallographica Section A Foundations and Advances 70, a1 (2014): C600. http://dx.doi.org/10.1107/s2053273314093991.

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Native biological macromolecules contain intrinsic light elements such as sulfur in proteins and phosphorus in nucleic acids. Native-SAD phasing utilizes the anomalous signals from light elements for de novo structure determination: first the substructure of anomalous scatterers is determined; phase evaluation for the entire structure then follows. Synchrotron beamlines are expected to be ideal instruments for native-SAD phasing due to their brilliant and energy-tunable x-rays. However, anomalous signals from light elements are typically very weak at x-ray energies accessible to most synchrotr
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13

&NA;. "Low-dose OCs do not increase MI risk in nonsmokers or light smokers." Reactions Weekly &NA;, no. 857 (2001): 4. http://dx.doi.org/10.2165/00128415-200108570-00009.

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14

&NA;. "Low-dose OCs do not increase MI risk in nonsmokers or light smokers." Inpharma Weekly &NA;, no. 1293 (2001): 16. http://dx.doi.org/10.2165/00128413-200112930-00042.

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15

Kawakubo, Yo, Mariko Iizuka, Itsuro Matsuo, and Muneo Ohkido. "Low dose ultraviolet light induces N-acetyltransferase activation in cultured human epidermal keratinocytes." Journal of Dermatological Science 6, no. 1 (1993): 55. http://dx.doi.org/10.1016/0923-1811(93)91026-q.

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16

Афанасьев, А. Ю., А. Ю. Бояринцев, И. А. Голутвин та ін. "Изменение характеристик переизлучающих волокон Y-11 и O-2 под действием гамма облучения". Журнал технической физики 128, № 12 (2020): 1973. http://dx.doi.org/10.21883/os.2020.12.50337.104-20.

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The effect of 60Co gamma radiation on the intensity of the reemitted light at the exit from WLS-fibers of Y-11 M and O-2 M type WLS fibers and the subsequent restoration of the characteristics of irradiated fibers after exposure to room temperature are investigated. Irradiation of a low dose rate (0.048 Mrad / h) to a dose of 1 Mrad leads to a slight decrease in the intensity of the reemitted light at the exit of both types of fibers, and with a further increase in the dose, the curve does not change. When irradiated with a dose rate of 0.158 Mrad / h, the characteristics of both types of fibe
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17

Yang, Ming-Yeh, Kai-Chih Chang, Liang-Yü Chen, and Anren Hu. "Low-dose blue light irradiation enhances the antimicrobial activities of curcumin against Propionibacterium acnes." Journal of Photochemistry and Photobiology B: Biology 189 (December 2018): 21–28. http://dx.doi.org/10.1016/j.jphotobiol.2018.09.021.

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18

Scholze, Martin, and Andreas Kortenkamp. "Statistical Power Considerations Show the Endocrine Disruptor Low-Dose Issue in a New Light." Environmental Health Perspectives 115, Suppl 1 (2007): 84–90. http://dx.doi.org/10.1289/ehp.9364.

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19

Chung, Jonathan H. "Shedding Light on Incidental Findings on Low-Dose Lung Cancer Screening Chest Computed Tomography." Annals of the American Thoracic Society 14, no. 9 (2017): 1393–94. http://dx.doi.org/10.1513/annalsats.201706-450ed.

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20

Sun, Z., F. Tuitje, and C. Spielmann. "A review of high‐resolution microscopic ghost imaging with a low‐dose pseudothermal light." Journal of Microscopy 284, no. 1 (2021): 3–11. http://dx.doi.org/10.1111/jmi.13048.

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21

Kluibenschedl, A., MD Lamare, WA Nelson, NG Barr, and CD Hepburn. "Low irradiance amplifies negative effects of ocean acidification on recruitment of coralline algae communities." Marine Ecology Progress Series 674 (September 16, 2021): 103–13. http://dx.doi.org/10.3354/meps13829.

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Coralline algae play foundational roles in coastal ecosystems and are globally significant components of benthic habitats down to the limits of the photic zone. Despite their vulnerability to ocean acidification (OA) and importance in low light environments, there is a limited understanding of how the interplay between irradiance and OA influences coralline reproduction and recruitment. To better understand this interaction, a 212 d experiment was run exposing coralline communities to 2 pH levels (present-day pH 8.03, OA pH 7.65) and a gradient of daily light dose (0.35, 0.17 and 0.1 mol m-2 d
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22

Sveshtarov, Vasil, S. Nencheva-Sveshtarova, R. Grozdanova, and K. Prodanova. "Superluminous Devices Versus Low-Level Laser for Temporomandibular Disorders." Acta Medica Bulgarica 45, no. 1 (2018): 11–15. http://dx.doi.org/10.2478/amb-2018-0002.

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AbstractThe aim of this study is to compare the pain intensity reduction between the mean radiation doses per session of gallium-aluminum-arsenide (GaAIAs) laser with superluminous diodes (SLD) in four of the most common pain-related chronic temporomandibular disorders (TMD) - local myalgia, myofascial pain, myofascial pain with a referral, and arthralgia. This study was implemented on 124 patients with pain-related temporomandibular disorders according to the DC/TMD criteria. We applied trigger point oriented near-infrared laser (785 nm, 100 s, 8 J/cm2) and SLD cluster sessions (the cluster i
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23

Savickiene, Jurate, Grazina Treigyte, Ceslava Aleksandraviciene, and Ruta Navakauskiene. "Low-dose ionizing radiation effects on differentiation of HL-60 cells." Open Life Sciences 5, no. 5 (2010): 600–612. http://dx.doi.org/10.2478/s11535-010-0085-2.

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AbstractThe biological effects of low-dose radiation have attracted attention, but data are currently insufficient to fully understand the beneficial role of the phenomenon. In the present study, we have investigated the effects of low doses of gamma-irradiation alone and in combination with all-trans-retinoic acid (RA) on proliferation, apoptosis and differentiation of the human promyelocytic leukemia HL-60 cells. Changes in cell behavior and protein expression were determined with the use of light and fluorescent microscopy, immunocytochemical and Western blot analysis. Low-dose irradiation
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24

Mookerjee, Anjali, Ritu Gupta, Atul Sharma, Tapan Saikia, and Lalit Kumar. "Lenalidomide Plus Low-Dose Dexamethasone Compared with Thalidomide Plus Low-Dose Dexamethasone: A Randomised Phase III Study." Blood 118, no. 21 (2011): 2932. http://dx.doi.org/10.1182/blood.v118.21.2932.2932.

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Abstract Abstract 2932 Background: We prospectively studied the efficacy and safety of Lenalidomide and Thalidomide in conjugation with low-dose dexamethasone in previously untreated symptomatic multiple myeloma (MM) patients. The results from an interim analysis of this on-going trial are presented. Methods: Between 1st March 2009 and 30th June 2011, 56 patients with previously untreated symptomatic MM were enrolled to receive 4 cycles of either Lenalidomide 25 mg daily from day 1 to 21 of a 28-day cycle (Arm A) or Thalidomide 100 to 200 mg daily (Arm B). Patients in both arms received dexame
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25

Bhartiya, Archana, Darren Batey, Silvia Cipiccia, et al. "X-ray Ptychography Imaging of Human Chromosomes After Low-dose Irradiation." Chromosome Research 29, no. 1 (2021): 107–26. http://dx.doi.org/10.1007/s10577-021-09660-7.

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AbstractStudies of the structural and functional role of chromosomes in cytogenetics have spanned more than 10 decades. In this work, we take advantage of the coherent X-rays available at the latest synchrotron sources to extract the individual masses of all 46 chromosomes of metaphase human B and T cells using hard X-ray ptychography. We have produced ‘X-ray karyotypes’ of both heavy metal–stained and unstained spreads to determine the gain or loss of genetic material upon low-level X-ray irradiation doses due to radiation damage. The experiments were performed at the I-13 beamline, Diamond L
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26

Leapman, R. D. "Subcellular Composition Based On Light-Element EELS." Microscopy and Microanalysis 3, S2 (1997): 927–28. http://dx.doi.org/10.1017/s1431927600011521.

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Recent work on biological electron energy-loss spectroscopy (EELS) in the analytical electron microscope has focused on measuring concentrations of the important elements, calcium and phosphorus. Analysis of the light elements, for which EELS was originally thought to be best suited, has so far not yielded much useful information from biological specimens. Whereas low-loss fine structure has been analyzed successfully to measure distributions of water and protein in frozen-hydrated cells, core-edge fine structure cannot be recorded at sufficiently low dose to obtain useful chemical information
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27

Maiti, Debabrata, Jing Zhong, Zheng Zhang, et al. "Polyoxomolybdate (POM) nanoclusters with radiosensitizing and scintillating properties for low dose X-ray inducible radiation-radiodynamic therapy." Nanoscale Horizons 5, no. 1 (2020): 109–18. http://dx.doi.org/10.1039/c9nh00374f.

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X-rays with high deep tissue penetration could be acted as an excellent excited light source for enhanced photodynamic therapy (PDT), avoiding the weak penetration of near-infrared light and further improving the therapeutic efficiency of PDT.
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28

Cakir, Murteza, Abdullah Colak, Cagatay Calikoglu, et al. "Once the Light Touch to the Brain: Cytotoxic Effects of Low-Dose Gamma-Ray, Laser Light, and Visible Light on Rat Neuronal Cell Culture." Eurasian Journal of Medicine 48, no. 2 (2016): 76–83. http://dx.doi.org/10.5152/eurasianjmed.2015.0304.

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29

Eikermann, M., K. Renzing-Köhler, and J. Peters. "Probability of acceptable intubation conditions with low dose rocuronium during light sevoflurane anaesthesia in children." Acta Anaesthesiologica Scandinavica 45, no. 8 (2001): 1036–41. http://dx.doi.org/10.1034/j.1399-6576.2001.450819.x.

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30

Campbell, P., and C. Murdock. "Cardiac amyloidosis-sustained clinical and free light chain response to low dose thalidomide and corticosteroids." Internal Medicine Journal 36, no. 2 (2006): 137–39. http://dx.doi.org/10.1111/j.1445-5994.2005.01021.x.

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31

El-Badawi, M. G., J. A. Fatani, H. Bahakim, and M. A. Abdalla. "Light and electron microscopic observations on the cerebellum of guinea pigs following low-dose methotrexate." Experimental and Molecular Pathology 53, no. 3 (1990): 211–22. http://dx.doi.org/10.1016/0014-4800(90)90045-f.

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32

Bittencourt, Rosane, Andreia D. Almeida, Joao R. Friederich, et al. "Low Dose Thalidomide for the Treatment of Multiple Myeloma." Blood 106, no. 11 (2005): 5146. http://dx.doi.org/10.1182/blood.v106.11.5146.5146.

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Abstract In the last two decades, we have seen a radical change in the therapy and prognosis of Multiple Myeloma (MM). Recent research on the role of the bone marrow microenvironment as integrant part of the biology of MM and the possible therapeutic interference at this level are leading to control and regression of the malignant plasma cell clone with a recognized clinical impact. Thalidomide, an old drug thought to interfere on the bone marrow microenvironment, is active not only for the treatment of refractory patients but also, as was recently shown, for induction and/or remission mainten
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33

Liu, Zhongrong, Hulin Chen, Huilan Yang, Jie Liang, and Xuemei Li. "Low-Dose UVA Radiation-Induced Adaptive Response in Cultured Human Dermal Fibroblasts." International Journal of Photoenergy 2012 (2012): 1–11. http://dx.doi.org/10.1155/2012/167425.

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Objective.To investigate the mechanism of the adaptive response induced by low-dose ultraviolet A (UVA) radiation.Methods.Cultured dermal fibroblasts were irradiated by a lethal dose of UVA (86.4 J/cm2) with preirradiation of single or repetitive low dose of UVA (7.2 J/cm2). Alterations of cellular morphology were observed by light microscope and electron microscope. Cell cycle and cellular apoptosis were assayed by flow cytometer. The extent of DNA damage was determined by single-cell gel electrophoresis (SCGE).Results.The cultured dermal fibroblasts, with pretreatment of single or repetitive
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34

Shin, Gwy-Am, Karl G. Linden, Michael J. Arrowood, and Mark D. Sobsey. "Low-Pressure UV Inactivation and DNA Repair Potential of Cryptosporidium parvum Oocysts." Applied and Environmental Microbiology 67, no. 7 (2001): 3029–32. http://dx.doi.org/10.1128/aem.67.7.3029-3032.2001.

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ABSTRACT Because Cryptosporidium parvum oocysts are very resistant to conventional water treatment processes, including chemical disinfection, we determined the kinetics and extent of their inactivation by monochromatic, low-pressure (LP), mercury vapor lamp UV radiation and their subsequent potential for DNA repair of UV damage. A UV collimated-beam apparatus was used to expose suspensions of purifiedC. parvum oocysts in phosphate-buffered saline, pH 7.3, at 25�C to various doses of monochromatic LP UV. C. parvuminfectivity reductions were rapid, approximately first order, and at a dose
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35

Shin, Gwy-Am, and Karl G. Linden. "Reactivation of Giardia lamblia cysts after exposure to low-pressure UV irradiation." Canadian Journal of Microbiology 61, no. 7 (2015): 513–16. http://dx.doi.org/10.1139/cjm-2014-0844.

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In this study, we determined the repair capabilities of Giardia lamblia cysts when they were exposed to low-pressure (LP) UV and then 4 different repair conditions. A UV collimated beam apparatus was used to expose shallow suspensions of G. lamblia cysts in buffered reagent water (PBS, pH 7.2) to various doses of LP UV irradiation. After UV irradiation, samples were exposed to 4 repair conditions (light and dark repair conditions with 2 temperatures (25 °C and 37 °C) for each condition). The inactivation of G. lamblia cysts by LP UV was very extensive (∼5 log10) even with a low dose of LP UV (
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36

Prasad, Amritha, Michael Gänzle, and M. S. Roopesh. "Inactivation of Escherichia Coli and Salmonella Using 365 and 395 nm High Intensity Pulsed Light Emitting Diodes." Foods 8, no. 12 (2019): 679. http://dx.doi.org/10.3390/foods8120679.

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High intensity pulsed light emitting diode (LED) treatment is a novel approach to inactivate foodborne pathogens. The objective of this study was to evaluate the antibacterial potential of high intensity 365 (UV-A) and 395 nm (NUV-Vis) LED treatments against Escherichia coli and Salmonella enterica at high and low water activity (aw) conditions, and to understand the influence of different process parameters on their antibacterial efficacy. Bacteria at high (in phosphate buffer saline, PBS) and low aw (aw = 0.75) conditions were treated with both the LEDs with specific doses at a fixed distanc
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37

Sillifant, Kate, Jacqueline Muir, Mary Crabb, and Stephen Read. "Monitoring of patients on high dose antipsychotic medication." Psychiatric Bulletin 21, no. 10 (1997): 612–14. http://dx.doi.org/10.1192/pb.21.10.612.

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In the light of recently published Royal College of Psychiatrists' guidelines on the use of high dose antipsychotic medication, electrocardiographic and blood investigations were performed on 11 patients with learning disabilities receiving such treatment. All patients had normal electrocardiograms (ECGs). Four patients had asymptomatic low white cell counts and mild anaemia was detected in three individuals. Three patients were hyponatraemic; liver function tests were essentially normal. Issues around routine monitoring of such patients are discussed.
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38

Zhang, Xin, Jingying Liao, Peijun Li, et al. "The study of light yield increase after low dose rate irradiation in Y3+ doping PbWO4 crystals." Journal of Crystal Growth 240, no. 1-2 (2002): 321–29. http://dx.doi.org/10.1016/s0022-0248(02)00881-3.

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39

Lu, Ping, Xiaoyi Bao, Narayan Kulkarni, and Kellie Brown. "Gamma ray radiation induced visible light absorption in P-doped silica fibers at low dose levels." Radiation Measurements 30, no. 6 (1999): 725–33. http://dx.doi.org/10.1016/s1350-4487(99)00233-4.

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40

Tyson, Terence L., Nathan H. Feick, Patrick F. Cravalho, Erin E. Flynn-Evans, and Leland S. Stone. "Differential Effects of Low-Dose Alcohol versus Acute Sleep Deprivation on Light-Evoked Pupil Response Dynamics." Journal of Vision 19, no. 10 (2019): 73a. http://dx.doi.org/10.1167/19.10.73a.

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41

Kanavy, H. E., M. A. Warycha, H. Hamilton, et al. "Enhancing DNA repair in the skin: A pilot study of low-dose chloroquine and ultraviolet light." Journal of Clinical Oncology 28, no. 15_suppl (2010): 8566. http://dx.doi.org/10.1200/jco.2010.28.15_suppl.8566.

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42

Kastritis, Efstathios, Ioanna Dialoupi, Maria Gavriatopoulou, et al. "Primary treatment of light-chain amyloidosis with bortezomib, lenalidomide, and dexamethasone." Blood Advances 3, no. 20 (2019): 3002–9. http://dx.doi.org/10.1182/bloodadvances.2019000147.

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Key Points Bortezomib with dexamethasone and low-dose lenalidomide is an active therapy for previously untreated patients with AL amyloidosis. VRD can induce MRD-negative responses, but nonhematologic toxicity may be significant in patients with advanced disease.
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43

Ahmad, Syed Bilal, Fiona E. McNeill, Soo Hyun Byun, et al. "Ultra-Violet Light Emission from HPV-G Cells Irradiated with Low Let Radiation from 90Y; Consequences for Radiation Induced Bystander Effects." Dose-Response 11, no. 4 (2013): dose—response.1. http://dx.doi.org/10.2203/dose-response.12-048.ahmad.

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44

Guo, Fang, Huiqian Zeng, Wanqing Ji, Yongjiang Zheng, and Ping He. "Dose- and time-dependent effects of low molecular weight heparin on trophoblast." Materials Express 10, no. 1 (2020): 145–51. http://dx.doi.org/10.1166/mex.2020.1622.

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Low molecular weight heparin (LMWH) has been successfully applied in the treatment of pregnancy complications associated with pro-thrombotic and antiphospholipid syndrome (APS). The underlying mechanism remains enigmatic. The purpose of this study was to explore the effects of time and dosage of LMWH on the proliferation and apoptosis of human trophoblast. The biological function of LMWH on primary trophoblast was evaluated by quantitative real-time PCR (qRT-PCR), by detecting the expression of proliferation genes SDS22, APPL1, CyclinB1, as well as the expression of apoptosis-related gene Surv
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45

Allam, Ahmed A., Salah N. Maodaa, Rasha Abo-Eleneen, and Jamaan Ajarem. "Protective Effect of Parsley Juice (Petroselinum crispum, Apiaceae) against Cadmium Deleterious Changes in the Developed Albino Mice Newborns (Mus musculus) Brain." Oxidative Medicine and Cellular Longevity 2016 (2016): 1–15. http://dx.doi.org/10.1155/2016/2646840.

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Parsley was used as a probe of the current experiment to prevent the behavioral, morphological and biochemical changes in the newborn brain following the administration of cadmium (Cd) to the pregnant mice. The nonanesthetized pregnant mice were given daily parsley juice (Petroselinum crispum) at doses of 20 mg/kg and 10 mg/kg. Pregnant mothers were given Cd at a dose of 30 mg/kg divided into 3 equal times. The newborns have been divided into 6 groups: Group A, mothers did not take treatment; Groups B and C, mothers were treated with low and high dose of parsley, respectively; Group D, mothers
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46

Ruedas, Angel, Ricardo Perez, Valentin Garcia, et al. "Tailored Low Dose Lenalidomide with Low Dose Dexamethasone (len/dex) in Previously Treated Patients with Multiple Myeloma Older Than 70 Years Requiring Treatment." Blood 114, no. 22 (2009): 4950. http://dx.doi.org/10.1182/blood.v114.22.4950.4950.

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Abstract Abstract 4950 Background & Aims The management of elderly patients with Multiple Myeloma (MM) previously treated requiring further therapy (although in most cases palliative) is very difficult due to the presence of concomitant diseases, decreased bone marrow reserve, systemic toxicity, relatively decreased renal function and general problems of old age. As in this setting the tolerability of standard doses of conventional chemotherapy, high doses of dexamethasone or IMiDs is a concern, we report the preliminary results of the combination of tailored low doses of lenalidomide (len
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Li, I.-Chen, Ting-Wei Lin, Tung-Yen Lee, et al. "Oral Administration of Armillaria mellea Mycelia Promotes Non-Rapid Eye Movement and Rapid Eye Movement Sleep in Rats." Journal of Fungi 7, no. 5 (2021): 371. http://dx.doi.org/10.3390/jof7050371.

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The present study aimed to explore whether water and ethanol extracts of Armillaria mellea mycelia produce sedative and hypnotic effects in rats. Male Sprague–Dawley rats were surgically implanted with two electroencephalogram electrodes on the skull and an electromyogram electrode on neck muscle to evaluate the alterations in rapid eye movement (REM) and non-REM (NREM) sleep after oral administration of the water and ethanol extracts. Following post-surgical recovery, thirty-six rats were randomly divided into four treatment groups and two control groups. They were treated orally with vehicle
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48

Rutz, Jochen, Aicha Benchellal, Wajdi Kassabra, et al. "Growth, Proliferation and Metastasis of Prostate Cancer Cells Is Blocked by Low-Dose Curcumin in Combination with Light Irradiation." International Journal of Molecular Sciences 22, no. 18 (2021): 9966. http://dx.doi.org/10.3390/ijms22189966.

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Although anti-cancer properties of the natural compound curcumin have been reported, low absorption and rapid metabolisation limit clinical use. The present study investigated whether irradiation with visible light may enhance the inhibitory effects of low-dosed curcumin on prostate cancer cell growth, proliferation, and metastasis in vitro. DU145 and PC3 cells were incubated with low-dosed curcumin (0.1–0.4 µg/mL) and subsequently irradiated with 1.65 J/cm2 visible light for 5 min. Controls remained untreated and/or non-irradiated. Cell growth, proliferation, apoptosis, adhesion, and chemotax
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Bianchi-Alves, M. R., E. C. C. Celeghini, R. P. de Arruda, et al. "17 TESTICULAR HISTOPATHOLOGICAL CHARACTERISTICS OF RAMS TREATED WITH LOW-LEVEL LASER THERAPY: PRELIMINARY RESULTS." Reproduction, Fertility and Development 26, no. 1 (2014): 122. http://dx.doi.org/10.1071/rdv26n1ab17.

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Testicular degeneration is caused by the loss of testicular thermoregulation induced by high environmental temperature, reproductive disruptions, fever, and others processes. Low-level laser therapy (LLLT) is an important tool to induce cellular proliferation and to stimulate mitosis. This biostimulatory effect was observed in the seminiferous epithelium of rats treated with LLLT, obtaining better results using a cumulative dose of 28.05 J cm–2 rather than 46.80 J cm–2 (Taha and Valojerdi 2004 Lasers Surg. Med. 34, 352–359). Thus, the aim of this study was to evaluate the effect of different L
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Shangloo, Prenika, Midhat Syed, and Sangeeta Gupta. "Effect of monosodium glutamate on liver of adult albino rats: a light microscopic study." International Journal of Research in Medical Sciences 9, no. 5 (2021): 1442. http://dx.doi.org/10.18203/2320-6012.ijrms20211883.

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Background: Monosodium glutamate (MSG) or Aji-no-moto is the common flavouring agent which is inadvertently used in all the packed and ready to use food items. Its use has grabbed the attention with reporting of Chinese restaurant syndrome and many more side effects. This flavouring agent effects almost all the organs of the human body but the statistics regarding its ill effects are very limited, thus no objections are being raised for its use in eatables. In current study we planned to analyse the pathological effects of MSG on the liver of adult albino rats.Methods: The study was conducted
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