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Journal articles on the topic 'Low solubility'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Lajoie, Léo, Anne-Sylvie Fabiano-Tixier, and Farid Chemat. "Water as Green Solvent: Methods of Solubilisation and Extraction of Natural Products—Past, Present and Future Solutions." Pharmaceuticals 15, no. 12 (2022): 1507. http://dx.doi.org/10.3390/ph15121507.

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Water is considered the greenest solvent. Nonetheless, the water solubility of natural products is still an incredibly challenging issue. Indeed, it is nearly impossible to solubilize or to extract many natural products properly using solely water due to their low solubility in this solvent. To address this issue, researchers have tried for decades to tune water properties to enhance its solvent potential in order to be able to solubilise or extract low-water solubility compounds. A few methods involving the use of solubilisers were described in the early 2000s. Since then, and particularly in

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2

Rimstidt, J. Donald. "Quartz solubility at low temperatures." Geochimica et Cosmochimica Acta 61, no. 13 (1997): 2553–58. http://dx.doi.org/10.1016/s0016-7037(97)00103-8.

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3

Consuelo Gamboa, Irma, Hernan Rios, Raul Barraza, and Patricia Sanhueza. "Behavior of low-solubility detergents." Journal of Colloid and Interface Science 152, no. 1 (1992): 230–36. http://dx.doi.org/10.1016/0021-9797(92)90022-e.

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4

Aghnatios, C., R. Losno, and F. Dulac. "A fine fraction of soil used as an aerosol analogue during the DUNE experiment: sequential solubility in water, decreasing pH step-by-step." Biogeosciences 11, no. 17 (2014): 4627–33. http://dx.doi.org/10.5194/bg-11-4627-2014.

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Abstract. A soil sample collected in a desert aerosol source area near Douz (southern Tunisia) was dry-sieved at 20 μm in order to extract the fraction similar to a wind-generated aerosol, and was used to seed mesocosms during the DUNE experiment (a DUst experiment in a low Nutrient, low chlorophyll Ecosystem). In this work, said "aerosol-like" fine dust was sequentially leached by short contacts with water at initial pHs, decreasing from seven to one, representing various wet environmental conditions. For each step, the solubility of a given element is calculated as the amount of its dissolve

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Ingall, E.D., Y. Feng, A.E Longo, et al. "Enhanced Iron Solubility at Low pH in Global Aerosols." Atmosphere 9 (May 22, 2018): art. no. 201. https://doi.org/10.3390/atmos9050201.

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The composition and oxidation state of aerosol iron were examined using synchrotron-based iron near-edge X-ray absorption spectroscopy. By combining synchrotron-based techniques with water leachate analysis, impacts of oxidation state and mineralogy on aerosol iron solubility were assessed for samples taken from multiple locations in the Southern and the Atlantic Oceans; and also from Noida (India), Bermuda, and the Eastern Mediterranean (Crete). These sampling locations capture iron-containing aerosols from different source regions with varying marine, mineral dust, and anthropogenic influenc

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Pandey, Sonam, Tanuj Pandey, Sameer Khan, and Suchita Wamankar. "Enhancement of Low Solubility and Low Permeability Drug Azithromycin Using Crystallization Techniques." International Journal of Advanced Multidisciplinary Research and Studies 4, no. 6 (2024): 917–21. https://doi.org/10.62225/2583049x.2024.4.6.3532.

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Azithromycin, a macrolide antibiotic, has poor solubility and low bioavailability, limiting its therapeutic effectiveness. This review explores crystallization techniques- — cooling crystallization to enhance its solubility and permeability. These methods improve dissolution rates, bioavailability, and permeability across biological membranes. Challenges like stability, regulatory concerns, and manufacturing scalability are discussed. Future research should focus on refining these techniques and combining them with other delivery strategies to optimize Azithromycin’s clinical efficacy.

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7

Benatti, Carlos R., Richard M. Epand, and M. Teresa Lamy. "Low cholesterol solubility in DODAB liposomes." Chemistry and Physics of Lipids 145, no. 1 (2007): 27–36. http://dx.doi.org/10.1016/j.chemphyslip.2006.10.002.

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8

Paulson, Anthony J., Mark M. Benjamin, and John F. Ferguson. "Zn solubility in low carbonate solutions." Water Research 23, no. 12 (1989): 1563–69. http://dx.doi.org/10.1016/0043-1354(89)90122-x.

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9

Adarsh, Kesharwani, Kesharwani Anuradha, Amman Maqbool Md., Pathak Supriya, and Kumar Mishra Manoj. "Solubilization Enhancement Techniques: An Overview." Pharmaceutical and Chemical Journal 4, no. 6 (2017): 121–30. https://doi.org/10.5281/zenodo.13889183.

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Solubility enhancement is a technique used for the hydrophobic drugs. Low aqueous solubility is the major problem, due to which drugs cannot reach the therapeutic level. Most of drugs weakly acidic and weakly basic with poor aqueous solubility. Low aqueous solubility is the major problem encountered with formulation development of new chemical entities as well as for the generic development. Among all newly discovered chemical entities about 40% drugs are lipophilic and fail to reach therapeutic range due to their poor water solubility. Drug with poor water solubility cause slow dissolution ra

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10

Barrère, Caroline, Marie Hubert-Roux, Carlos Afonso, et al. "Tandem mass spectrometry of low solubility polyamides." Analytica Chimica Acta 808 (January 2014): 3–9. http://dx.doi.org/10.1016/j.aca.2013.03.064.

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11

Rodriguez, Garrett V., and Joanna M. Millunchick. "Predictive modeling of low solubility semiconductor alloys." Journal of Applied Physics 120, no. 12 (2016): 125310. http://dx.doi.org/10.1063/1.4962849.

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12

Tanaka, Yusuke, Toshiyuki Baba, Koji Tagawa, Ryoichi Waki, and Shunji Nagata. "Prediction of Oral Absorption of Low-Solubility Drugs by Using Rat Simulated Gastrointestinal Fluids: The Importance of Regional Differences in Membrane Permeability and Solubility." Journal of Pharmacy & Pharmaceutical Sciences 17, no. 1 (2014): 106. http://dx.doi.org/10.18433/j37606.

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Purpose. This study aimed to develop a novel approach for predicting the oral absorption of low-solubility drugs by considering regional differences in solubility and permeability within the gastrointestinal (GI) tract. Methods. Simulated GI fluids were prepared to reflect rat in vivo bile acid and phospholipid concentrations in the upper and lower small intestine. The saturated solubility and permeability of griseofulvin (GF) and albendazole (AZ), a drug with low aqueous solubility, were measured using these simulated fluids, and fraction absorbed (Fa) at time t after oral administration was

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Ibrahim, Naz, Shahla Smail, Nozad Hussein, and Tara Abdullah. "Solubility enhancement of nimodipine using mixed hydrotropic solid dispersion technique." Zanco Journal of Medical Sciences 24, no. 3 (2020): 386–94. http://dx.doi.org/10.15218/zjms.2020.046.

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Background and objective: Low aqueous solubility of active pharmaceutical ingredients has an effect on both formulation development and bioavailability. Nimodipine is an antihypertensive agent with low oral bioavailability, which might be attributed to the extremely poor water solubility. This study aimed to increase the solubility of nimodipine in water using hydrotropes and solid dispersion technology to increase dissolution rate compared to the marketed drug product. Methods: Solubility of nimodipine was determined separately in sodium acetate, sodium citrate, sodium benzoate, and niacinami

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14

Saad, Al-Shahrani and Mohammad Javed Ansari*. "SOLUBILITY EVALUATIONS OF OSIMERTINIB MESYLATE IN PHYSIOLOGICAL BUFFERS." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 04 (2018): 2610–15. https://doi.org/10.5281/zenodo.1220226.

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Limited water solubility of drugs is a prevailing problem to efficient drug delivery as a huge proportion of available drugs are poorly water soluble. Poorly soluble drugs suffer with low or incomplete oral absorptions leading to low or variable bioavalibilities. Osimertinib mesylate is a novel anticancer drug for the treatment of lung cancer. It is reported to have low absorption and exposure at therapeutic doses of 80 mg which could be due to low solubility in gastrointestinal tract. It is important to evaluate pH solubility profile of the drug over the gastrointestinal pH range in order to

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15

Roda, Ana, Alexandre Paiva, and Ana Rita C. Duarte. "Therapeutic Liquid Formulations Based on Low Transition Temperature Mixtures for the Incorporation of Anti-Inflammatory Drugs." Pharmaceutics 13, no. 10 (2021): 1620. http://dx.doi.org/10.3390/pharmaceutics13101620.

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Most nonsteroidal anti-inflammatory drugs (NSAIDs) present poor aqueous solubility, impairing their efficiency in physiological media. In this context, Low Transition Temperature Mixtures (LTTMs) are a promising platform to overcome drugs’ poor solubility, forming therapeutic liquid formulations. In this work, the LTTMs of citric acid:L-arginine:water (C:A:W) and glycerol:sorbitol (G:S) were studied in terms of their features and assessed in terms of their ability to increase the solubility of six NSAIDs in physiological media. The physicochemical properties of LTTMs were characterized by stat

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16

Lan, Tian, Jie Yang, Zhi-jie Yang, and Hong-wen Wu. "Spray-Dried Griseofulvin-Lactose Matrix for Enhanced Solubility Using a Spray-Drying Biochemical Process." Journal of Chemistry 2022 (July 5, 2022): 1–7. http://dx.doi.org/10.1155/2022/8372048.

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Griseofulvin (GF) is a hydrophobic drug with a low solubility. In order to improve the solubility of GF, which has low water solubility, this report uses the spray-drying technique to prepare complexes with lactose to promote the solubility and oral bioavailability of GF. The solution samples were spray dried using different ratios of ethanol or acetone solutions as dissolution media. By characterization of the obtained spray-dried powders, we found that the solubility of the different groups of samples obtained by spray drying was increased, and similarly, their dissolution rates were also in

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17

Kuchekar, Ashwin Bhanudas, Ashwini Gawade, and Sanjay Boldhane. "Hydrotropic Solubilization: An Emerging Approach." Journal of Drug Delivery and Therapeutics 11, no. 1-s (2021): 200–206. http://dx.doi.org/10.22270/jddt.v11i1-s.4724.

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Drug development plays an important role in patient safety and effectiveness. The therapeutic suitability of a new drug depends on the solubility. The solubility of the sparingly soluble drug remains a problem in identifying new active compounds. Solubility plays an important role in achieving optimal drug concentration. Low solubility is not only a concern for the production of formulations, but also an obstacle from the outset when identifying active chemicals for therapeutic purposes. Due to its simplicity in terms of ease of administration and economy, the oral route is the preferred route

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18

Deshmukh, Dr Prasad, Sangam Nimkar, Amruta Phuse, Dipti Ruikar, and Dipti Bonde. "A Systemic Review on Techniques of Solubility Enhancement for Poor Water-Soluble Drugs." Asian Journal of Pharmaceutical Research and Development 12, no. 3 (2024): 247–56. http://dx.doi.org/10.22270/ajprd.v11i3.1420.

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Background Investigating novel methods to improve solubility in order to increase drug absorption along with improving pharmaceutical formulations. Main body of the abstractThe limited water solubility of active pharmaceutical ingredients constrains their pharmacological efficacy. However, the solubility parameter must not be compromised, necessitating the use of various strategies to improve their bioavailability. The solubility of drugs significantly impacts their pharmacokinetics, pharmacodynamics, as well as other characteristics like drug distribution, protein binding, and absorption. Thi

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19

Bhandari, Yash, Sunayana Rathore, Vaishali Raghuwanshi, Shehnaz Sheikh, Yashmita Sharma, and Ishan Dubey. "A Practical Approach for Solubility Enhancement of Leflunomide." Oriental Journal Of Chemistry 39, no. 5 (2023): 1386–88. http://dx.doi.org/10.13005/ojc/390537.

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Leflunomide is an anti-rheumatic medication. As it has low water solubility, it shows low absorption in gastrointestinal tract. The reported solubility of Leflunomide is approx 25.27 mcg/ml. Leflunomide comes under BCS Class II in which it has low solubility and high permeability. In this study, gel entrapment technique is used to enhance the solubility of leflunomide. In this technique Hydroxy Propyl Methyl Cellulose and Ethyl Cellulose are used which are converted to gel with the addition of different organic solvent such as Ethanol, Chloroform, Di chloro Methane etc. The analyses of the sam

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20

Nakamura, Masaki, Yoshiko Fujii, Toshinobu Shigematsu, and Toyoichiro Shigi. "Solubility of4He in Liquid3He at Very Low Temperatures." Japanese Journal of Applied Physics 26, S3-1 (1987): 69. http://dx.doi.org/10.7567/jjaps.26s3.69.

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21

Kalinina, I. G., G. P. Belov, K. Z. Gumargalieva, and Yu A. Shlyapnikov. "Solubility of low-molecular-mass compounds in copolymers." Polymer Science Series B 48, no. 4 (2006): 206–8. http://dx.doi.org/10.1134/s156009040607013x.

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Koromyslov, A. V., and A. Ya Kupryazhkin. "The low-temperature solubility of helium in quartz." Technical Physics 62, no. 9 (2017): 1415–18. http://dx.doi.org/10.1134/s1063784217090122.

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23

Perez, Michel, Fabien Perrard, Véronique Massardier-Jourdan, Xavier Kleber, Vincent Schmitt, and Alexis Deschamps. "Low Temperature Solubility Limit of Copper in Iron." Materials Science Forum 500-501 (November 2005): 631–38. http://dx.doi.org/10.4028/www.scientific.net/msf.500-501.631.

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The solubility limit of copper in iron at temperature lower than 700°C is not precisely known because copper diffusion is too slow to reach an equilibrium with classical experimental techniques involving long range diffusion. However, fine precipitation of copper can lead to an equilibrium in a reasonable ageing time. Hence, coupling ThermoElectric Power and Small Angle X-ray Scattering techniques leads to a precise estimation of this solubility limit in the temperature range 500°C-700°C. Values obtained are confirmed by Tomographic Atom Probe and give results much higher than what is usually

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Nakamura, Masaki, Yoshiko Fujii, Toyoichirō Shigi, and Keisuke Nagao. "Solubility of4He in Liquid3He at Very Low Temperatures." Journal of the Physical Society of Japan 57, no. 5 (1988): 1676–80. http://dx.doi.org/10.1143/jpsj.57.1676.

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25

Esteves-Oliveira, M., C. Apel, N. Gutknecht, et al. "Low-fluence CO2 laser irradiation decreases enamel solubility." Laser Physics 18, no. 4 (2008): 478–85. http://dx.doi.org/10.1134/s11490-008-4023-1.

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26

Brem, Jürgen, László-Csaba Bencze, Arto Liljeblad, et al. "Chemoenzymatic Preparation of 1-Heteroarylethanamines of Low Solubility." European Journal of Organic Chemistry 2012, no. 17 (2012): 3288–94. http://dx.doi.org/10.1002/ejoc.201200330.

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27

Sugano, Kiyohiko. "Computational Oral Absorption Simulation for Low-Solubility Compounds." Chemistry & Biodiversity 6, no. 11 (2009): 2014–29. http://dx.doi.org/10.1002/cbdv.200900101.

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Esteves-Oliveira, M., C. Apel, N. Gutknecht, et al. "Low-fluence CO2 laser irradiation decreases enamel solubility." Laser Physics 18, no. 4 (2008): 478–85. http://dx.doi.org/10.1134/s1054660x08040233.

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29

Schoenbeck, Mark A., and Claudia M. Rauter. "A Low-Cost Exercise Relating Glutamate Solubility to pH & Buffering Capacity." American Biology Teacher 84, no. 7 (2022): 422–25. http://dx.doi.org/10.1525/abt.2022.84.7.422.

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The concept of solubility, and its relation to molecular structure, is important for understanding the properties of biological molecules in solution as they interact with the solvent and with each other. To demonstrate the relation between structure, solubility, and buffering capacity, we report a low-cost laboratory exercise using monosodium glutamate (MSG) as a model solute. Students observe how glutamate solution initially resists acidification and how glutamate solubility is first decreased and then restored with acidification. Students should interpret these observations relative to the

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Pigeon, Pascal, Feten Najlaoui, Michael James McGlinchey, Juan Sanz García, Gérard Jaouen, and Stéphane Gibaud. "Unravelling the Role of Uncommon Hydrogen Bonds in Cyclodextrin Ferrociphenol Supramolecular Complexes: A Computational Modelling and Experimental Study." International Journal of Molecular Sciences 24, no. 15 (2023): 12288. http://dx.doi.org/10.3390/ijms241512288.

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We sought to determine the cyclodextrins (CDs) best suited to solubilize a patented succinimido-ferrocidiphenol (SuccFerr), a compound from the ferrociphenol family having powerful anticancer activity but low water solubility. Phase solubility experiments and computational modelling were carried out on various CDs. For the latter, several CD-SuccFerr complexes were built starting from combinations of one or two CD(s) where the methylation of CD oxygen atoms was systematically changed to end up with a database of ca. 13 k models. Modelling and phase solubility experiments seem to indicate the p

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Gaurav, Mundhe* Dr. V. M. satpute S. R. Ghodake. "Nanosuspensions In Pharmaceutical Sciences: A Review." International Journal of Pharmaceutical Sciences 2, no. 11 (2024): 856–66. https://doi.org/10.5281/zenodo.14191654.

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Regardless of the method of administration, the solubility of drugs is essential to their efficiency. However, many newly discovered drugs suffer from poor water solubility and low bioavailability, leading to limited development efforts. Nanosuspension technology offers a solution for these "Brickellia" candidates by enhancing their solubility and bioavailability. Nanosuspensions improve medication stability and can be easily prepared for water-insoluble drugs using techniques such as highpressure homogenizers, wet mills and emulsion solvent evaporation. Additives like stabilizers, solvents, b

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Jiang, Xu-Liang, Dinusha Damunupola, and Christian Bruckner. "Meso-tetra(dioxanyl)porphyrins: Neutral, low molecular weight, and chiral porphyrins with solubility in aqueous solutions." Journal of Porphyrins and Phthalocyanines 25, no. 07n08 (2021): 734–40. http://dx.doi.org/10.1142/s108842462150070x.

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The synthesis of the low-molecular weight, meso-tetra(dioxan-2-yl)porphyrin with considerable solubility in aqueous solution is described. The key intermediate dioxan-2-carbaldehyde is accessible in either racemic or in stereo-pure forms from commercially available starting materials in three steps. Using 4 × 1 or 2 + 2-type syntheses provide the porphyrin in modest yields. While the racemic aldehyde created an intractable mixture of diastereomers, the enantiopure aldehyde created a single enantiomer of the target porphyrin. The porphyrin was spectroscopically characterized. As its free base o

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Xiong, Yongliang. "The aqueous geochemistry of thallium: speciation and solubility of thallium in low temperature systems." Environmental Chemistry 6, no. 5 (2009): 441. http://dx.doi.org/10.1071/en08086.

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Environmental context. The aqueous geochemistry of thallium is not well known in comparison with cadmium and lead, although it is more highly toxic, and at the same time has a wide range of industrial applications. A database allowing us to reliably predict the speciation and solubility of thallium in various environments in low temperature systems would be invaluable in providing some understanding of thallium’s mobilisation and mitigation. We propose here such a thermodynamic database based on critical reviews. Abstract. Thallium is a highly toxic element, and at the same time it has a wide

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Kolluru, Lakshmi, Prachi Atre, and Syed Rizvi. "Characterization and Applications of Colloidal Systems as Versatile Drug Delivery Carriers for Parenteral Formulations." Pharmaceuticals 14, no. 2 (2021): 108. http://dx.doi.org/10.3390/ph14020108.

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Preparing a suitable formulation for parenteral administration is already a difficult task; this, coupled with poor water-soluble new chemical entity (NCE), complicates this situation even further. There are several methodologies available to enhance water solubility, but this alone does not entail successful formulation. Making a micro/nano emulsion with a suitable surfactant not only increases the drug solubility but also the cell membrane permeability. Thus, not only biopharmaceutic classification system (BCS)-II (low solubility compounds) but also BCS-III (low permeability) and BCS-IV drug

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Wilkin, Richard T., and David A. Rogers. "Nickel sulfide formation at low temperature: initial precipitates, solubility and transformation products." Environmental Chemistry 7, no. 6 (2010): 514. http://dx.doi.org/10.1071/en10076.

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Environmental context Remediation technologies often rely on manipulation of redox conditions or natural redox processes to favour microbial sulfate-reduction and mineral sulfide formation for treatment of inorganic contaminants in groundwater, including nickel. However, few data are available on the structural properties, solubility and mineral transformation processes involving nickel sulfides. These data are needed in order to constrain the long term performance of groundwater remediation efforts. Abstract The formation of nickel sulfides has been examined experimentally over the temperatur

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Zhang, Min, Richen Zhong, Chang Yu, and Hao Cui. "The Immobility of Uranium (U) in Metamorphic Fluids Explained by the Predominance of Aqueous U(IV)." Minerals 13, no. 3 (2023): 427. http://dx.doi.org/10.3390/min13030427.

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The solubility of uranium (U) in hydrothermal fluid is thought to be controlled by oxidation. In general, uranium is mainly transported as U(VI) in oxidized fluid, but precipitated as U(IV) in reduced fluid. However, many geological observations indicate that metamorphic fluids, which are buffered by metamorphic rocks with oxidized protoliths such as oxidized pelite or altered marine basalt, are not enriched in U. To explore the reason of the low solubility of U in metamorphic fluids, we simulated the hydrous speciation and solubility of U in fluids that are in equilibrium with rocks. The simu

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Naureen, Faiza, Yasar Shah, Shahnaz, and Fazli Khuda. "Determination of Saturated Solubility of Mirtazapine Using UV Visible Spectrophotometer." Pharmaceutical Communications 3, no. 01 (2024): 27–34. https://doi.org/10.55627/pharma.003.001.0799.

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Solubility is an important parameter for designing new drug formulations. Many drugs possess poor aqueous solubility hence, poor bioavailability. Many pharmaceutical industries face these issues while designing new drug entities. A new assessment revealed that about 70–90% of drug candidates are in the development stage, while up to 40% of the marketed products are water-insoluble which leads to low bioavailability, reduced therapeutic effects, and increased dose. Poor solubility is one of the major driving forces behind the development of numerous new drugs. There are various techniques to en

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Werner, K. V., H. L. Che, M. K. Lei, T. L. Christiansen, and M. A. J. Somers. "Low Temperature Carburizing of Stainless Steels and the Development of Carbon Expanded Austenite*." HTM Journal of Heat Treatment and Materials 77, no. 1 (2022): 3–15. http://dx.doi.org/10.1515/htm-2022-0001.

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Abstract Low-temperature carburizing dramatically enhances the inherently low wear resistance of austenitic stainless steels due to the formation of a carbon-supersaturated solid solution, i.e. expanded austenite. The formation of expanded austenite from low-temperature carburizing has been intensively investigated. However, the influence of chemical composition of the stainless steel on the carburizing response has not received the same interest. This contribution addresses the effect of the chemical composition on low-temperature carburizing in terms of carbon solubility, decomposition of ex

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Santosh Kumar, Rada, and Annu Kumari. "Preparation and evaluation of sulfamethoxazole solid dispersion employing starch citrate-a new solubility enhancer." Journal of Drug Delivery and Therapeutics 9, no. 2-s (2019): 237–42. http://dx.doi.org/10.22270/jddt.v9i2-s.2655.

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Sulfamethoxazole used widely as a broad spectrum antibiotic. However, its solubility and dissolution rate is very low due to poor solubility in water. Solid dispersion technique was selected for the current research to improve solubility and drug absorption from of Sulfamethoxazole. A new solubility enhancer starch citrate was selected prepared and characterized for its solubility, viscosity, swelling index, gelling property, particle size, etc. Prepared Sulfamethoxazole solid dispersion was evaluated for drug content and in vitro dissolution. Keywords: Sulfamethoxazole, Starch citrate, Solid

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Simonsen, Tor Ivan, Demi Tristan Djajadi, and Sune Tjalfe Thomsen. "Modified Hydrothermal Pretreatment Conditions Enhance Alcohol Solubility of Lignin from Wheat Straw Biorefining." Biomass 5, no. 2 (2025): 23. https://doi.org/10.3390/biomass5020023.

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Lignin-rich residues from lignocellulosic biorefineries remain underutilized, limiting their economic viability. This study demonstrates how modifying hydrothermal pretreatments with temperatures and additives enhances the lignin-rich residue’s solubility in alcohol, a key step toward its valorization in biofuel and material applications. Effective carbohydrate removal greatly enhanced the residue’s alcohol solubility, supporting both saccharification and lignin utilization. Notably, a 5% hydrogen peroxide treatment doubled the residue’s alcohol solubility, reaching ~40%, while maintaining sim

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Lee, Ji Ho, and Kun Sang Lee. "Enhanced Wettability Modification and CO2 Solubility Effect by Carbonated Low Salinity Water Injection in Carbonate Reservoirs." Journal of Chemistry 2017 (2017): 1–10. http://dx.doi.org/10.1155/2017/8142032.

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Carbonated water injection (CWI) induces oil swelling and viscosity reduction. Another advantage of this technique is that CO2 can be stored via solubility trapping. The CO2 solubility of brine is a key factor that determines the extent of these effects. The solubility is sensitive to pressure, temperature, and salinity. The salting-out phenomenon makes low saline brine a favorable condition for solubilizing CO2 into brine, thus enabling the brine to deliver more CO2 into reservoirs. In addition, low saline water injection (LSWI) can modify wettability and enhance oil recovery in carbonate res

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Iraci, L. T., R. R. Michelsen, S. F. M. Ashbourn, T. A. Rammer, and D. M. Golden. "Uptake of hypobromous acid (HOBr) by aqueous sulfuric acid solutions: low-temperature solubility and reaction." Atmospheric Chemistry and Physics 5, no. 6 (2005): 1577–87. http://dx.doi.org/10.5194/acp-5-1577-2005.

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Abstract. Hypobromous acid (HOBr) is a key species linking inorganic bromine to the chlorine and odd hydrogen chemical families. We have measured the solubility of HOBr in 45-70wt% sulfuric acid solutions representative of upper tropospheric and lower stratospheric aerosol composition. Over the temperature range 201-252 K, HOBr is quite soluble in sulfuric acid, with an effective Henry's law coefficient, H*=104-107mol L-1atm-1. H* is inversely dependent on temperature, with ΔH=-45.0±5.4 kJ mol-1 and ΔS=-101±24 J mol-1K-1 for 55-70wt% H2SO4 solutions. Our study includes temperatures which overl

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Sugiyanti, Dina, Sri Anggrahini, Yudi Pranoto, Chairil Anwar, and Umar Santoso. "Low Molecular Weight Chitosan from Shrimp Shell Waste using Steam-Explosion Process Under Catalyst of Phosphotungstic Acid." Oriental Journal of Chemistry 35, no. 1 (2019): 193–99. http://dx.doi.org/10.13005/ojc/350122.

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The limited solubility of chitosan had limiting its application in any fields. Low molecular weight chitosan (LWCS) potentially produced to improve its solubility and characteristics. Steam explosion process was used to breakdown the intermolecular hydrogen bonding and phosphotungstic acid used as catalyst to attact the glycosidic bond and produce shorter chain. The optimum temperature and phosphotungstic acid concentration on steam explosion process presented highest water solubility at T=160oC and 0.1%, respectively. It didn’t showed any change of functional group on FTIR analysis, no morpho

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Gerald, Ugodi W., Mbah J. Chika, Nwodo J. Ngozi, Ozochi A. Oluchi, and Momoh Nafisa. "Utilization of Hydrotropes on Solubilization of Tenoxicam in Aqueous Solution." Asian Journal of Chemical Sciences 14, no. 6 (2024): 98–105. http://dx.doi.org/10.9734/ajocs/2024/v14i6337.

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Hydrotropy is a unique solubilization technique utilize to depict the increase in the solubility of a solute by the addition of a second solute (in large amount) resulting in an increase in the aqueous solubility solute of interest. Therapeutic effectiveness of a drug depends on its aqueous solubility and bioavailability. The purpose of the study was to establish tenoxicam solubility in hydrotropes at very low concentrations as well as explore solubilization behavior of the drug in mixed hydrotropic systems at very low concentrations. The methodology involved the use of rotary flask shaker at

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Nigal, Aparna, Avinash Darekar, and Ravindranath B. Saudagar. "Use of Nanohybrid Material for Formulation, Development and Evaluation of Pharmaceutical Dosage Form Containing the Low Solubility Active Pharmaceutical Ingredient." Journal of Drug Delivery and Therapeutics 9, no. 6-s (2019): 34–43. http://dx.doi.org/10.22270/jddt.v9i6-s.3715.

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In oral absorption of a drug, the drug first dissolves and then is absorbed by diffusion through gastrointestinal membranes. The gastrointestinal environment is aqueous in nature and it is well-known that one-third of the drug population is water insoluble. Hence, there is a need for enhancement of the solubility and dissolution of such drugs. In this work, enhancement of the solubility and dissolution of the practically insoluble drug Rosuvastatin Calcium was achieved by formation of nanohybrids using microwave-induced diffusion (MIND), which ultimately leads to bioavailability enhancement. n

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Burkhande, Ninad S., V. P. Wankhade, S. C. Atram, N. N. Bobade, and S. D. Pande. "Development of Co-Crystallization Technique to Improve Solubility of Anti-Diabetic Drug." Asian Journal of Pharmaceutical Research and Development 11, no. 4 (2023): 30–35. http://dx.doi.org/10.22270/ajprd.v11i4.1282.

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Co-crystallization is a useful crystal engineering approach for changing the physiochemical and structural characteristics of drug crystals. Pharmaceutical co-crystals are nonionic supramolecular complexes that can be utilized in pharmaceutical development to change physiochemical qualities including solubility, stability, and bioavailability without changing the chemical makeup of API. Canagliflozin Hemihydrate is a anti-diabetic drug. Canagliflozin belongs to class IV drug in BCS classification. i.e. low solubility and low permeability. The major problem of this class drug is it slow solubil

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Mirza, Mohd Aamir. "Solubility Enhancement of Diclofenac Using Solid Dispersions." International Journal of Pharmaceutics & Pharmacology 5, no. 1 (2021): 1–6. http://dx.doi.org/10.31531/2581-3080.1000154.

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Background: The phenomenon which gives rise to a homogenous system, formed by the dissolution of solute in a solvent is known as solubility. Low solubility is the limiting factor in formulation development. Diclofenac being BCS class II drug have low aqueous solubility of 0.00401mg/ml. Amongst various solubility enhancement techniques, solid dispersion is the easiest one. Objective: Present work is primarily focused on the development of solid dispersions of diclofenac through solvent evaporation technique utilizing Eudragit E100 as a carrier. Methods: Solid dispersion consists of at least one

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Gupta, Jyoti, and Anjana Devi. "Solubility EnhancementTechniques forPoorly Soluble Pharmaceuticals: A Review." Indian Journal of Pharmaceutical and Biological Research 7, no. 02 (2019): 09–16. http://dx.doi.org/10.30750/ijpbr.7.2.2.

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Among newly discovered chemical entities about 40% drugs are hydrophobic which are failed to reach market due to their low aqueous solubility. For orally administered drugs solubility is one of the rate limiting parameter to achieve their desired concentration in systemic circulation for pharmacological response.Drug efficacy can be limited due to poor aqueous solubility and some drugs also show side effects like gastric irritation, peptic ulcers,due to their poor solubility. Because of solubility problem of many drugs the bioavailability of them gets affected and hence solubility enhancement

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Rani T, Neelima, Pavani A, Sobhita Rani P, and Srilakshmi N. "Solubility Enhancement of Poorly Soluble Drug Simvastatin by Solid Dispersion Technique." Research in Pharmacy and Health Sciences 2, no. 2 (2016): 91–95. http://dx.doi.org/10.32463/rphs.2016.v02i02.16.

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This study aims to formulate solid dispersions (SDs) of Simvastatin (SIM) to improve the aqueous solubility, dissolution rate and to facilitate faster onset of action. Simvastatin is a BCS class II drug having low solubility & therefore low oral bioavailability. In the present study, SDs of simvastatin different drug-carrier ratios were prepared by kneading method. The results showed that simvastatin solubility & dissolution rate enhanced with polymer SSG in the ratio 1:7 due to increase in wetting property or possibly may be due to change in crystallinity of the drug.

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Janda, Václav, Marek Šváb, and Ondra Šráček. "(Re)Mineralization of Drinking Water with Calcite or Dolomite." Chemické listy 119, no. 2 (2025): 105–8. https://doi.org/10.54779/chl20250105.

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It is shown in the contribution that increasing the concentrations of calcium and magnesium in low mineralized or demineralized water by filtering through a layer of dolomite or limestone cannot bring the desired result. The solubility of both minerals in water is low, and the solubility of carbon dioxide in water, which could increase the solubility of carbonate minerals, corresponding to its partial pressure in the atmosphere, is also small. Thus, water mineralization performed in this way does not lead to values suitable for high-quality drinking water.

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