To see the other types of publications on this topic, follow the link: Lowsuit.

Journal articles on the topic 'Lowsuit'

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 32 journal articles for your research on the topic 'Lowsuit.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Patuti, Taufik Akbar. "Perlindungan Hukum Bagi Hak Pengguna Jalan Dari Kelalaian Penyelenggara Jalan Melalui Civil Lowsuit Ditinjau Dari Hukum Perdata." Jurnal Hukum Legalita 6, no. 2 (2024): 171–80. https://doi.org/10.47637/legalita.v6i2.1538.

Full text
Abstract:
Penelitian ini membahas perlindungan hukum bagi hak pengguna jalan terhadap kelalaian yang dilakukan oleh penyelenggara jalan melalui mekanisme gugatan perdata (civil lawsuit). Kelalaian dalam pemeliharaan dan penyelenggaraan jalan dapat menyebabkan kerugian material maupun non-material bagi pengguna jalan, sehingga diperlukan mekanisme hukum untuk melindungi hak-hak tersebut. Pendekatan hukum perdata digunakan untuk menganalisis tanggung jawab penyelenggara jalan berdasarkan prinsip-prinsip pertanggungjawaban hukum, termasuk wanprestasi dan perbuatan melawan hukum (onrechtmatige daad). Penelitian ini juga mengeksplorasi prosedur pengajuan gugatan, bentuk ganti rugi yang dapat diperoleh, serta kendala dalam implementasinya. Hasil penelitian menunjukkan bahwa mekanisme gugatan perdata memberikan solusi hukum bagi pengguna jalan, namun perlu didukung oleh regulasi yang lebih spesifik dan penegakan hukum yang konsisten untuk menjamin perlindungan yang efektif. Kata Kunci: Perlindungan hukum, pengguna jalan, hukum perdata.
APA, Harvard, Vancouver, ISO, and other styles
2

Hengist, Aaron, Russell Davies, Peter Rogers, et al. "Restricting Sugar or Carbohydrate Intake Does Not Impact Physical Activity Level or Energy Intake Over 24 Hours Despite Changes in Substrate Use: A Randomised Crossover." Current Developments in Nutrition 6, Supplement_1 (2022): 444. http://dx.doi.org/10.1093/cdn/nzac057.010.

Full text
Abstract:
Abstract Objectives To determine the effects of dietary sugar or carbohydrate restriction on physical activity energy expenditure, energy intake, and physiological outcomes across 24 hours. Methods In a randomised, open-label crossover design, twenty-five healthy men (n = 10) and women (n = 15) consumed three diets over a 24-hour period: moderate carbohydrate and sugar content (MODSUG = 50% carbohydrate [20% sugars], 15% protein, 35% fat); low sugar content (LOWSUG = 50% carbohydrate [<5% sugars], 15% protein, 35% fat); and low carbohydrate content (LOWCHO = 8% carbohydrate [<5% sugars], 15% protein, 77% fat). Postprandial metabolic responses to a prescribed breakfast (20% EI) were monitored under laboratory conditions before an ad libitum test lunch, with subsequent diet and physical activity monitoring under free-living conditions until blood sample collection the following morning. Results The MODSUG, LOWSUG and LOWCHO diets resulted in similar mean [95%CI] rates of both physical activity energy expenditure (771 [624,919] vs 677 [565,789] vs 802 [614,991] kcal·d−1; p = 0.29] and energy intake (2071 [1794,2347] vs 2195 [1918,2473] vs 2194 [1890,2498] kcal·d−1; p = 0.34), respectively. The LOWCHO condition elicited the lowest glycaemic and insulinemic responses to breakfast (p < 0.01) but the highest 24-h increase in LDL-cholesterol (p < 0.001), with no differences between the MODSUG and LOWSUG treatments. Leptin concentrations were decreased over 24-h of consuming LOWCHO relative to LOWSUG (p < 0.01). Conclusions When energy density is controlled for, restricting either sugar or total dietary carbohydrate does not modulate physical activity level and energy intake over a 24-hour period despite large changes in metabolism. Funding Sources This study was supported by The Rank Prize Funds and Kenniscentrum Suiker and Voeding.
APA, Harvard, Vancouver, ISO, and other styles
3

Jovanović, N., M. Petronijević, S. Vrzić-Petronijević, J. Opalić, Z. Bogdanović, and J. Dotlić. "OUTCOME OF THE DELIVERIES WITH BREECH PRESENTATION ACCORDING TO THE PERFORMED MANUAL ASSISTANCE." Praxis medica 38, no. 1 (2010): 109–12. http://dx.doi.org/10.70949/pramed201001337j.

Full text
Abstract:
<p>Introduction: Delivery with foetus in breech presentation carries a dilemma for obstetrician concerning the method of choice which would be the best for the foetus and the mother. Goal: The aim of this study was to analyse the frequency of breech presentation, mode of delivery and the methods of manual assistance concerning the Apgar score of the children at delivery. Method: Study involved all women with a child in breech position who gave birth in the Institute for Gynaecology and Obstetrics of the Clinical Centre of Serbia in Belgrade during the period of six years. Results: Frequency of the breech presentation in the investigated period was 4.5%. In the last three years children in breech presentation are delivered more often by caesarean section (2.7-3.1%) than vaginally (1.6-1.7%). In vaginal deliveries manual assistance by Bracht/Lowset was performed most often- in 70.5%. At the second place is manual assistance by Bracht- in 18, 2%. Feet extraction of the foetus is performed in 4.4% of deliveries. The frequency of Smeli-Veit assistance is 6.7%, while the Forceps was used in 0.3% of cases. High Apgar score from 8-10 have foetuses born using the methods of assistance by Bracht/Lowset and Bracht (83 85%) with high statistical significance in comparison with other three methods of manual assistance (p<0.001). There is no statistical significance concerning Apgar score between the methods of Bracht/Lowset and Bracht (p=0.59). Conclusion: By using the adequate manual assistance which is the least traumatic for the foetus we achieve better postnatal prognosis. </p>
APA, Harvard, Vancouver, ISO, and other styles
4

Tominaga, Ai. "Two Cases of Medical Lowsuits Related to Breast Cancer Misdiagnosis by Ultrasound Provide Important Lessons for Clinical Practice." Nihon Nyugan Kenshin Gakkaishi (Journal of Japan Association of Breast Cancer Screening) 22, no. 1 (2013): 90–94. http://dx.doi.org/10.3804/jjabcs.22.90.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Garay, María Adriana. "El derecho de superficie en el Código Civil y Comercial de la Nación y su implicancia notario registral." Revista de Derecho Notarial y Registral │Universidad Blas Pascal 7, no. (2020) (2021): 31–44. http://dx.doi.org/10.37767/2362-3845(2020)002.

Full text
Abstract:
El derecho real de superficie contemplado en el Código Civil y Comercial de la Nación permite aplicar el mismo no sólo a forestaciones y plantaciones sino a construcciones. El objeto del mismo es de esta manera mucho más amplio lo cual obliga a su análisis jurídico en la normativa de fondo y en las resoluciones catastrales y registrales, en las cuales el notario tendrá un rol fundamental no sólo en el asesoramiento de la multiplicidad de negocios a realizarse sino en la instrumentación de los mismos.ABSTRACTThe real surface right contemplated in the Civil and Commercial Code of the National lowsit to be applied not only to af forestation and plantations, but to constructions. Its purpose ist hus much broader, which requires its legal analysis in the substantive regulations and in cadastral and registry resolutions, in which the notary will have a fundamental role not only in advising on the multiplicity of business es to be carried out but in the instrumentation of the same.
APA, Harvard, Vancouver, ISO, and other styles
6

Ahsanullah, M., G. Hamedani, and J. Wesołowski. "Linearity of regressions inside top-k-lists and related characterizations." Studia Scientiarum Mathematicarum Hungarica 49, no. 4 (2012): 436–45. http://dx.doi.org/10.1556/sscmath.49.2012.4.1219.

Full text
Abstract:
López-Blázquez and Weso lowski [6] introduced the top-k-lists sequence of random vectors and elaborated the usefulness of such data. They also developed the distribution of top-k-lists and their properties arising from various probability distributions, such as standard exponential distribution and uniform distribution on (0, 1). In this paper, we study the linearity of regressions inside top-k-lists and then based on this study we present characterizations of certain distributions.
APA, Harvard, Vancouver, ISO, and other styles
7

Price, A. R. G., and C. Izsak. "Is the Arabian Gulf really such a lowspot of biodiversity?: Scaling effects and management implications." Aquatic Ecosystem Health & Management 8, no. 4 (2005): 363–66. http://dx.doi.org/10.1080/14634980500457757.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Shu, X., C. Zou, and Z. Shen. "DOUBLE ANEUPLOIDY 48,XXY,+21 ASSOCIATED WITH A CONGENITAL HEART DEFECT IN A NEONATE." Balkan Journal of Medical Genetics 16, no. 2 (2013): 85–89. http://dx.doi.org/10.2478/bjmg-2013-0038.

Full text
Abstract:
ABSTRACT A neonate with a double aneuploidy associated with congenital heart defect (CHD) suffered from cyanosis after birth. He had typical features of Down syndrome (DS) including hypertelorism, slightly lowset ears with protruding pinna. Doppler echocardiography indicated complex congenital heart disease with an ostium secundum atrial septal defect, enlarged right ventricle, and mild tricuspid valve regurgitation. Further chromosomal analysis showed a karyotype of 48,XXY,+21: a double aneuploidy of DS and Klinefelter syndrome (KS). Until now, only seven cases of double aneuploidy associated with CHD defect have been reported
APA, Harvard, Vancouver, ISO, and other styles
9

Węglowski, Marek Stanisław, Adam Pietras, Stanisław Dymek, and Carter Hamilton. "Characterization of Friction Modified Processing – A Novel Tool for Enhancing Surface Properties in Cast Aluminium Alloys." Key Engineering Materials 504-506 (February 2012): 1231–36. http://dx.doi.org/10.4028/www.scientific.net/kem.504-506.1231.

Full text
Abstract:
Friction Modified Processing (FMP) is a novel solid state processing technique which can be used for microstructural modification of surface layers in metallic materials. The paper deals with the investigation of the influence of process parameters on the microstructure in the surface layer of a cast aluminum alloy. The FMP was conducted on a constructed welding machine equipped with appropriate devices (LOWSTIR and TermSTIR). The measurements of temperature in the stir zone were compared with a numerical model. Another model was developed to determine the quantitative relationships between mass of modified material and processing speeds over a wide experimental range. An exponential formula has been found to describe the relationship between mass of modified material and rotational speed. The evaluation of the traveling speed affecting the mass of the modified material was successfully approximated by linear functions.
APA, Harvard, Vancouver, ISO, and other styles
10

Fenton, E. W. "Correlations and spin susceptibility of lowst-energy Cooper pairing in an antiferromagnet." Solid State Communications 56, no. 12 (1985): 1033–37. http://dx.doi.org/10.1016/0038-1098(85)90865-8.

Full text
APA, Harvard, Vancouver, ISO, and other styles
11

Mori, Ryuhei. "Better protocol for XOR game using communication protocol and nonlocal boxes." Quantum Information and Computation 17, no. 15&16 (2017): 1261–76. http://dx.doi.org/10.26421/qic17.15-16-1.

Full text
Abstract:
Buhrman showed that an efficient communication protocol implies a reliable XOR game protocol. This idea rederives Linial and Shraibman’s lower bound of randomized and quantum communication complexities, which was derived by using factorization norms, with worse constant factor in much more intuitive way. In this work, we improve and generalize Buhrman’s idea, and obtain a class of lower bounds for randomized communication complexity including an exact Linial and Shraibman’s lower bound as a special case. In the proof, we explicitly construct a protocol for XOR game from a randomized communication protocol by using a concept of nonlocal boxes and Paw lowski et al.’s elegant protocol, which was used for showing the violation of information causality in superquantum theories.
APA, Harvard, Vancouver, ISO, and other styles
12

Xiong, Zihang, Mei Wang, Ruixiang Kan, and Jiayu Zhang. "YOLO-SAR: An Enhanced Multi-Scale Ship Detection Method in Low-Light Environments." Applied Sciences 15, no. 13 (2025): 7288. https://doi.org/10.3390/app15137288.

Full text
Abstract:
Nowadays, object detection has become increasingly crucial in various Internet-of-Things (IoT) systems, and ship detection is an essential component of this field. In low-illumination scenes, traditional ship detection algorithms often struggle due to poor visibility and blurred details in RGB video streams. To address this weakness, we create the Lowship dataset and propose the YOLO-SAR framework, which is based on the You Only Look Once (YOLO) architecture. As for implementing ship detecting methods in such challenging conditions, the main contributions of this work are as follows: (i) a low-illumination image-enhancement module that adaptively improves multi-scale feature perception in low-illumination scenes; (ii) receptive-field attention convolution to compensate for weak long-range modeling; and (iii) an Adaptively Spatial Feature Fusion head to refine the multi-scale learning of ship features. Experiments show that our method achieves 92.9% precision and raises mAP@0.5 to 93.8%, outperforming mainstream approaches. These state-of-the-art results confirm the significant practical value of our approach.
APA, Harvard, Vancouver, ISO, and other styles
13

Timothée, Lathion, and Piguet Claude. "Deciphering the Influence of Meridional versus Facial Isomers in Spin Crossover Complexes." Chem. Eur. J. 24, no. 2018 (2018): 16873–88. https://doi.org/10.5281/zenodo.1495095.

Full text
Abstract:
Chelate coordination of non-symmetrical didentate pyrazine-benzimidazole (L1) or pyridine-benzimidazole (L2) N-donor ligands around divalent iron in acetonitrile produces stable homoleptic triple-helical spin crossover [Fe(Lk)3]2+ complexes existing as mixtures of meridional (C1- symmetry) and facial (C3-symmetry) isomers in slow exchange on the NMR timescale. The speciation deviates from the expected statistical ratio mer/fac=3:1, a trend assigned to the thermodynamic trans-influence, combined with solvation effects. Consequently, the observed spin state FeII lowspin $FeII high-spin equilibria occurring in [Fe(Lk)3]2+ refer to mixtures of complexes in solution, an issue usually not considered in this field, but which limits rational structure-properties correlations. Taking advantage of the selective and quantitative formation of isostructural facial isomers in nonconstrained related spin crossover d-f helicates (HHH)- [LnFe(Lk)3]5+ (Ln is a trivalent lanthanide, Lk=L5, L6), we propose a novel strategy for assigning pertinent thermodynamic driving forces to each spin crossover triple-helical isomer. The different enthalpic contributions to the spin state equilibrium found in mer-[Fe(Lk)3]2+ and fac-[Fe(Lk)3]2+ reflect the Fe@N bond strengths dictated by the trans-influence, whereas a concomitant solvent-based entropic contribution reinforces the latter effect and results in systematic shifts of the spin crossover transitions toward higher temperature in the facial isomers.
APA, Harvard, Vancouver, ISO, and other styles
14

Puspita Ayu, Yolanda Dewi, Daeng Rahmatullah, and Istiyo Winarno. "Koordinasi Adaptif DOCR Pada Sistem Transmisi Loop Multi Generator Menggunakan Modified Firefly Algorithm-Artificial Neural Network." Jurnal Ilmiah Telsinas Elektro, Sipil dan Teknik Informasi 4, no. 1 (2022): 31–40. http://dx.doi.org/10.38043/telsinas.v4i1.2093.

Full text
Abstract:
Protection system is a very important component in the electric power distribution system. With good reliability, the distribution of electrical power will be better, one of which is by minimizing disruption to the system quickly, precisely and accurately. Components used in protection systems are directional overcurrent relays (DOCR). In this study proposed optimal and adaptive protection coordination using the Modified Firefly Algorithm-Artificial Neural Network (MFA-ANN) tested on the IEEE 9 real bus loop system with 4 generation combinations. Optimization using MFA will get the Time Delay Setting (TDS) and Ipickup (lowset) values. The ANN used is Backpropagation Lavenberg Marquardt (BPLM) After the BPLM learning process, we will get the weight and bias values of the training results and later as a reference value to get the value of TDS and Ipickup relay. The process will produce relay settings automatically based on the results of optimization and MFA-ANN training which are then simulated on the IEEE 9 bus loop system. The results achieved by MFA-ANN are suitable methods for modeling optimal and adaptive relay coordination systems. ANN training with the BPLM algorithm produces the smallest MSE value of 5.9308xE-10.
APA, Harvard, Vancouver, ISO, and other styles
15

Evans, David E., John K. Niparko, Josef M. Miller, Robert W. Jyung, and David J. Anderson. "Multiple-Channel Stimulation of the Cochlear Nucleus." Otolaryngology–Head and Neck Surgery 101, no. 6 (1989): 651–57. http://dx.doi.org/10.1177/019459988910100607.

Full text
Abstract:
To further test the feasibility of a central nervous system auditory prosthesis, the characteristics of the electrically evoked middle latency response were studied in a series of acutely anesthetized pigmented guinea pigs, with multi-channel penetrating cochlear nucleus electrodes placed into the cochlear nucleus under direct visualization. These stimulating electrodes consisted of a silicone substrate, with five stimulating pads each, sputtered with Iridium. Monopolar and bipolar stimulation were used. Threshold, latency, and input-output functions of the electrically evoked middle latency response were studied. Systematic differences were observed, depending on the site and parameters of stimulation. Principally, higher currents were required to produce waves of equal amplitude when the electrodes were closely spaced. For near electrode pairs, the maximum wave amplitudes obtainable within the limits of tissue safety were much lower than for distant electrode pairs. The slope of the growth function curve was steeper for widely spaced electrodes than for adjacent sites. Monopolar stimulation demonstrated maximum wave amplitudes with the lowst current Intensity, implying current spread to the entire cochlear nucleus with this stimulation montage. In some cases, threshold differences were observed, higher thresholds being associated with closely spaced elecrodes. These findings are consistent with simple models of the electric fields expected to be generated by these electrode arrays. The results support the hypothesis that activtalon of subpopulations of auditory brainstem neurons with multi-channel penetrating microelectrodes is possible.
APA, Harvard, Vancouver, ISO, and other styles
16

Mohammed Metwally, El Sayed Aly, Mohammed Abdel Fattah Desheesh, Doaa Mohammed Abd El-kawy Elmasry, Mahmoud Morshedy Farg, Hamada Mahmoud Youssef, and Rasha M. Elshinety. "Congenital skeletal malformations induced by lambda-cyhalothrin, dibenzalacetone and heptanone derivatives in embryos of albino mice." International Journal of Anatomy and Research 9, no. 1.3 (2021): 7912–27. http://dx.doi.org/10.16965/ijar.2021.109.

Full text
Abstract:
Background: Insecticides such as lambda-cyhalothrin(LCT), dibenzalacetone (DBA) and heptanone HD are teratogenic substances. Skeleton is one of the organs sensitive to teratogens during the period of organogenesis. Material and methods:This study was conducted on fifty adult female albino mice, divided randomly into four groups: Group I (control group, n= 5 received corn oil orally in adose of 10 mg /kg body weight), group II (LCT group, n=10 received LCT (nano 8%)10, 20 mg /kg body weight for each subgroup), group III (DBA group, n=20, received DBA (main) 10, 20 mg /kg body weight and DBA (nano 8%)) 10,20mg /kg body weight for each subgroup) and group IV (HD group, n=15, received HD (main) 10 mg /kg body weight and HD (nano 8%)) 10,50mg /kg body weight for each subgroup),The calculated treatment dissolved in 1 ml of corn oil by orogastric tube was given to the pregnant mice during the first week of pregnancy (1st, 3rd and 5th day).The delivered live and dead pups were examined externally, then double stained and prepared for skeletal examination by dissecting microscope. Results: All experimental groups showed various anomalies that can be categorized as the following: 1) presence of dead pups and resorption sites 2) macroscopic anomalies in the form of anencephaly, extended forelimb, cranioshisis, macroglossia, lowset ears, lage eye bulge, half body, amelia, internal rotation of forelimb and encephalocele. 3) skeletal anomalies by double staining of fetal skeleton showed incomplete ossification of nasal and interparietal bones, open arch of atlas, incomplete ossification of vertebrae, supernumerary ribs, wavy ribs, incomplete ossification of ribs and sternebrae, incomplete ossification of sternum, incomplete ossification of 5th metacarpal and terminal phalangal bones and incomplete ossification of tarsal , and phalangal bones. Conclusion: Lambda-cyhalothrin, dibenzalacetone and derivatives of heptanone result in numbers of congenital gross and skeletal abnormalities that indicate their teratogenic effect. KEY WORDS: Lambada, Congenital, Skeletal, Dibenzalacetone, Heptanone, Teratogenic.
APA, Harvard, Vancouver, ISO, and other styles
17

Górnicka, Magdalena, Jadwiga Hamulka, Lidia Wadolowska, et al. "Activity–Inactivity Patterns, Screen Time, and Physical Activity: The Association with Overweight, Central Obesity and Muscle Strength in Polish Teenagers. Report from the ABC of Healthy Eating Study." International Journal of Environmental Research and Public Health 17, no. 21 (2020): 7842. http://dx.doi.org/10.3390/ijerph17217842.

Full text
Abstract:
Today, the time spent actively is increasingly being replaced by screen-based media, although in some teenagers, a high level of physical activity (PA) and longer time spent in front of a screen (screen time, ST) may coexist as a mixed behavioral pattern. This study aimed to examine the association of the pattern created as activity (low/high ST with high PA) and inactivity patterns (low/high ST with low PA) with overweight, central obesity, and muscle strength in Polish teenagers taking into consideration socioeconomic and demographic factors. Cross-sectional data were collected from elementary school children (n = 1567), aged 11–13 years. Height, weight, waist circumference, and handgrip strength were measured. Body mass index (BMI) was calculated as the overweight measure, and the waist-to-height ratio (WHtR) was calculated as the central obesity measure. Data on ST, PA, socioeconomic status, demographics, and nutrition knowledge were collected by a questionnaire. Activity–inactivity patterns were defined by an a priori approach. Multivariate logistic regression modelling was applied. The most active pattern (lowST-highPA) was found in 17% of the total sample. Teenagers with the most inactive pattern (highST-lowPA) had over four times higher chance of general overweight. No association between WHtR ≥0.5 and highST-highPA pattern was found. Higher muscle strength (>1 SD) was associated only with high physical activity. Urban residence or lower socioeconomic status increased adherence to the most inactive pattern. From a public health perspective, implementing interventions promoting active patterns in 11–13-year-old teenagers is important for obesity prevention and enhanced physical fitness, especially in girls, teenagers living in urban areas, and from families with lower socio-economic status.
APA, Harvard, Vancouver, ISO, and other styles
18

Rappa, G., F. Anzanello, and A. Lorico. "CD24 expression and breast cancer stem cell phenotype." Journal of Clinical Oncology 27, no. 15_suppl (2009): 11106. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.11106.

Full text
Abstract:
11106 Background: Several studies suggest the existence of breast cancer-initiating cells (BCIC), responsible for tumor development and progression. Initial reports that only the CD44+CD24−/low subpopulation contains BCIC have been challenged by subsequent studies. We examined the relationship between CD24 and biological properties of breast cancer cells. Methods: MA-11 breast carcinoma cells, originating from bone marrow micrometastases, are CD44+ and have an heterogeneous expression of CD24 (214,000/cell; range 0–1,120,000). We have previously reported that upon in vitro culture as mammospheres under stem cell-like conditions, MA-11 cells acquired increased tumorigenicity and a CD44+CD24−/low phenotype. We have now investigated the relationship between CD24 expression and tumorigenicity in the MA-11 model. Results: Upon passage of MA-11 mammospheres in adherent culture, cells rapidly re-expressed CD 24. The rapid increase in CD24 was consistent with antigen up-regulation, not selection of CD24−/low cells. Exposure of adherent MA-11 cells to imatinib for 72h resulted in a reversible decrease in CD24 from 214,000 to 15,800/cell. CD44+CD24−/low cells, sorted by flow cytometry, generated CD44+CD24high, and CD44+CD24highgenerated CD44+CD24−/low. Immediately after sorting, >90% CD44+CD24−/low cells were in G0/G1. After 24–48 h in culture, cell cycle distribution, growth rate and invasiveness of the sorted cell populations were equivalent. Upon injection and s.c. growth, CD24 expression of CD44+CD24−/low populations and clones increased from 10,000 to 220,000/cell. Similarly, CD44+CD24−/low clones derived from human MCF-7 breast carcinoma cells formed tumors containing >99% CD44+CD24high cells. The average number of CD24 per cell was equivalent for tumors formed upon injection of CD44+CD24−/low, CD44+CD24+, mammosphere-derived cells or parental adherent MA-11 cells. The tumorigenic potentials of sorted CD44+CD24−/low, CD44+CD24−/lowsub-populations and clones in nu/nu mice were equivalent. Conclusions: CD44+CD24−/low breast cancer cells are not associated with increased tumorigenicity; the high CD24 level of mouse xenografts derived from both CD44+CD24−/low and CD44+CD24hi breast cancer cells suggests an important role for CD24 in tumor growth. No significant financial relationships to disclose.
APA, Harvard, Vancouver, ISO, and other styles
19

Struzik, Małgorzata, and Marta Gawlik. "The role of the nursing team in the care of patients with Kabuki syndrome." Medical Science Pulse 12, no. 3 (2018): 36–41. http://dx.doi.org/10.5604/01.3001.0012.5180.

Full text
Abstract:
Background: Kabuki syndrome is a rare genetic condition characterised by pathological changes within all the systems of the body, but with variable gene expression. All the patients described in the literature so far have specific facial features resembling the masks of actors from the Japanese Kabuki Theatre and mild to moderate mental impairment. Diagnosis is made based by genetic testing for mutations of the KMT2D and KDM6A genes. Therapy is mainly based on symptomatic alleviation of the effects of mutation, rehabilitation and improvement of the quality of patients’ life. Then prognosis of patients with Kabuki syndrome is closely related to the severity of symptoms, which is very variable. Aim of the study: The purpose of the study is to present the nursing problems based on the case report and to present complications caused by the disease entity. Material and methods: The criterion for including the patient in the study was the legal guardian’s (parent’s) consent for the child to participate in the study. Qualitative research was conducted using analysis of medical records, interview with the child and the child’s legal guardian, direct and indirect observation of the child for psycho-social changes related to the disease and interpretation of the data in the context of the theoretical knowledge and our own observations. Case report: The report is based on the case of a 16-year-old girl, diagnosed (at the age of fourteen) with rare genetic disorder – Kabuki syndrome. The patient experiences some characteristic symptoms – big, red lips, lowset and sticky-out ears, drooping eyelids and short fingers and toes. One of the first symptoms suggesting Kabuki syndrome were: spitting up during breastfeeding, problems with swallowing, motor clumsiness and epilepsy. The role of the nursing team during hospitalization was to take care because of habitual dislocation of patella, and to provide psychological suport. At present time the girl uses a wheelchair or she moves on her knees Results: The manifestations of chronic disease contribute to the feeling of excessive stress, regardless of the patient’s age. An adequate diet enriched with proteins contributes to the prevention of bedsores among individuals with Kabuki syndrome, immobilised to various degrees. Regular consultations with specialists, such as cardiologist, neurologist, gastroenterologist, orthopaedist, ophthalmologist, psychologist, orthodontist, speech therapist, immunologist, endocrinologist and dietician reduce the risk of complications associated with the disease in the patient with Kabuki syndrome. Early implementation of rehabilitation, focused to increase muscle tension, contributes to maintaining autonomy and self-care in patients with Kabuki syndrome.
APA, Harvard, Vancouver, ISO, and other styles
20

Gupta, Saurav, Vinod Gupta, Neerja Sharma, and Abhay Kumar Sinha. "To study the effect of compatible pesticides spray against major pests and diseases of Apple." International Journal of Agricultural Invention 7, no. 1 (2022): 39–45. https://doi.org/10.46492/ijai/2022.7.1.8.

Full text
Abstract:
A two year field trial at Shalimar campus, SKUAST-Kashmir was conducted to study the compatibility of various insecticides and fungicides against major pests and diseases of apple. Insecticides and fungicides are recommended to be sprayed separately without admixing suspensions involving huge labour and time components. Different pesticides and fungicides were sprayed with at five different phenological stages (fruit-let, fruit development stage-I and fruit development stage II). Standard controls comprising of recommended sprays were also given at these stages for comparison, in addition to unsprayed check. Observations with respect to foliage and fruit scab, Alternaria leaf blotch and percent mortality of European red mite (ERM) and San Jose Scale (SJS) were recorded at fruit-let, fruit development stage-I and fruit development-II stages. The pesticidal combination exhibiting physical incompatibility was discarded in the initial phase. Combined spray of fungicide and insecticide proved equally effective in controlling diseases and pests of apple in different stages. The experimental plants sprayed with mixtures of fungicides and insecticides at recommended concentrations exhibited significant reduction in apple scab, ALB, EMR and SJS in comparison to unsprayed check at fruit-let stage. Results revealed that treatment T5 (difenconazole + phosalone) proved superior in minimizing foliar scab incidence and intensity whereas treatment T3 (difenconazole + chlorpyriphos) and T16 (difenconazole) had minimum incidence (0.80%) and intensity (0.30%) of fruit scab. The trees sprayed with hexaconazole followed by chlorpyriphos (T9) result lowest disease incidence (0.23) of ALB and lowest intensity (0.17) was found in Haxaconozol followed by Milbactin (T10). T4 (Difenconazole + Milbactin) proved most effective in inflicting maximum ERM mortality (68.6%) and was at par with T7 (65.6%) followed by T14. Treatment T1 (Haxaconozole + Milbectin) shows 57 per cent mortality of SJS and was at par with T3 (Difenconazole + Chlorphriphos) and T12 (Chlorpyriphos) treatments. At fruit development stage-I, all the treatments controlled apple scab, ALB, ERM and SSJ significantly as compared to unsprayed check (table 2). T5 (Zineb +Chlorpyriphos) had least foliage scab incidence (2.63%) and T13 (Mancozeb) showed lowset intensity (0.70%), whereas T5 (Zineb + Chlorpyriphos) exhibited least fruit scab incidence (6.50%) followed by T8 (Mancozeb followed by Chlorphriphos) and lowest intensity were recorded in T2 (Mancozeb + Chlorpyriphos) and T8 (Mancozeb followed by Chlorphriphos) (02.03%). ALB incidence was significantly controlled by T3 (Mancozeb + Dicofol) and intensity was significantly controlled by T1 (Mancozeb +Quinalphos) followed by T2. Percent mortility of ERM was highest by T12 (Dicofol) (80.4 %) followed by treatment T5 (Zineb + Chlorpyriphos) (75.9) per cent. In case of SJS, treatment T10 (Quinalphos) and T7 (mancozeb + Quinalfos) was most promising with 79.3 and 78.3% mortality, respectively. At fruit development II, all the treatments significantly controlled apple scab, ALB, ERM and SJS in comparison to unsprayed check (table 3). Least leaf scab incidence and intensity was showed by treatment T5 Bitertinol+ Propargite (8.63 and 2.41 %, respectively) However, least fruit scab incidence was observed in trees sprayed with T3 (Flusilozole + Summer spray oil) while treatment T2 (Flusilozole + Propargite) showed lowest fruit scab intensity of 3.27 per cent. Bitertinol + summer spray oil (T6) sprayed trees had least ALB incidence (5.97%) while T7 (Difenconazole + Dimethoate) had least ALB intensity (2.65%). Percent mortility of ERM was highest by T14 Propargite effectively controlled ERM and was at par with treatment T15 and T8. Similarly In case of SJS treatment T7 (Difenconazole with Dimethoate) and T1, T4, T6, T9, T10 and T13 showed statistically similar performance. Thus compatible chemicals can effectively minimize labour, time and inputs.
APA, Harvard, Vancouver, ISO, and other styles
21

Babovic, Ivana, Snezana Plesinac, Zoran Radojicic, et al. "Vaginal delivery versus cesarean section for term breech delivery." Vojnosanitetski pregled 67, no. 10 (2010): 807–11. http://dx.doi.org/10.2298/vsp1010807b.

Full text
Abstract:
Background/Aim. The optimal method of delivery for breech presentation at term still remains a matter of controversy. This is probably due to the fact that the skills of vaginal breech delivery are being lost. The aim of this study was to examine risk factors: mother's age, parity, labor's duration, estimated neonatal birth weight for the mode of breech presentation delivery at term as well as the influence of the delivery mode on neonatal outcome. Methods. A retrospective study of 401 terms (more than 37 week's gestation) breech deliveries at the Institute of Gynecology and Obstetrics, Belgrade, from 2007 to 2008 was made. The following groups with respect to mode of delivery were included: the group I - vaginal delivery (VD) in 139 patients; the group II - urgent cesarean section (UCS) in 128 patients; and the group III - elective cesarean section (ECS) in 134 patients. Mother's age, parity, duration of VD, neonatal birth weight (BW), the Apgar score at 5th minute, and duration of stay in a neonatal intensive care unit (NICU) vere determined. Neonatal mortality and major neonatal morbidity were compared according to the route of delivery. Fetuses and neonates with hemolytic disease and fetal and neonatal anomalies were excluded from the study. For statistical analyses we performed Student's t test, ?2 likelihood ratio, Kruskall-Wallis test, Mann Whitney test, and ANOVA. Results. The mean age of patients in the group I was 28.29 ? 4.97 years, in the group II 29.68 ? 5.92 years and in the group III 30.06 ? 5.41 years. Difference in mother's age between the group I and III was significant (p = 0.022). In the group III there were 73.9% nuliparous similarly to the gropu II (73.4%). We performed ECS in 54.6% of the nuliparous older than 35 years, and 54.4% multiparous younger than 35 years were delivered by VD. The use of oxytocin for stimulation of vaginal labor was not associated with its duration (p = 0.706). Lowset maneuver was performed in 88.5% of the VD. Mean BW of neonantes was 3189.93 ? 399.42 g in the VD group, 3218.59 ? 517.71 g in the UCS and 3427.99 ? 460.04 g in the ECS group. Neonates of the estimated BW below 2 500 g were delivered by UCS in 5.5% cases, vaginally in 3.6% cases and by ECS in 2.2% cases. Neonates of the estimated BW above 3 500 g were delivered by ECS in 44.8% cases, vaginally in 23.0% cases and by UCS in 30.5% cases. There was a statistically significant difference between the VD and UCS groups (p = 0.004). Neonatal well-being was diagnosed in 75.5% of the neonates in the VD group, in 72.4% of the neonates in the ECS group, and in 65.5% of the neonates in the UCS group. The Apgar score at 5th min ? 8 was observed in 96% of the neonates in the VD group, in 97.5% of the neonantes in the ECS group and in 94.5% of the neonantes in the UCS group. In breech presentation, perinatal asphyxia remained increased in the VD group by 9.4% as compared with the UCS group, 5.5% (p = 0.001) and the ECS group, 3.0% (p = 0.016). Neonates stayed in NICU significantly longer after UCS compared with VD or ECS (7.21 ? 10.74 days vs 3.99 ? 1.33 days and 5.34 ? 2.88 days, respectively; p = 0.001 and p = 0.037, respectively). There was no diagnosed intracranial hemorrhage, brachial plexus injury and birth trauma in any groups. Also, there was no early neonatal death. Conclusion. For breech presentation elective cesarean section remains the major delevery method in nuliparous older than 35 years, while vaginal delivery is considered to be the method of choice in younger multiparous with ultrasonographically estimated neonatal birth weight 2 500-3 500 grams.
APA, Harvard, Vancouver, ISO, and other styles
22

Asyiah, Ai Kusmiati, and Ristina Siti Sundari. "Jalan Buntu Konsumen dalam Memproleh Perlindungan atas Sengketa Dengan Pelaku Usaha (Studi Kasus Customer dan Developer di Tasikmalaya)." JURNAL EKONOMI PERJUANGAN 2, no. 2 (2021). http://dx.doi.org/10.36423/jumper.v2i2.664.

Full text
Abstract:
Abstrak – Hubungan kegiatan usaha antara produsen dan konsumen di samping memberikan keuntungan juga sering menimbulkan konflik atau sengketa. Penellitian ini bertujuan untuk menelusuri hubungan bisnis antara customer dan developer yang menimbulkan sengketa yang tidak mendapatkan penyelesaian yang diajukan secara non litigasi. Penelitian ini merupakan studi kasus yang dianalisis secara deskripsi melalui proses dan prosedur yang berlaku. Hasil penelitian menunjukkan bahwa konsumen melaporkan masalahnya untuk bisa diselesaikan di Badan Penyelesaian Sengketa Konsumen (BPSK) terhadap Developer. Penyelesaian secara litigasi dengan gugatan perdata di Pengadilan Negeri tidak akomodatif dikarenakan birokrasi yang ribet dan proses perkara yang memakan waktu yang cukup panjang. Oleh karena demikian dengan dikeluarkannya Undang-undang Nomor 8 Tahun 1999 Tentang Perlindungan Konsumen, diharapkan dapat menjadi solusi dalam memfasilitasi konsumen yang merasa dirugikan oleh developer guna mengajukan pengaduan terhadap pelaku usaha tersebut kepada Badan Penyelesaian Sengketa (BPSK) di luar pengadilan. Kata Kunci: Sengketa, konsumen, pelaku usahaAbstract – Businnes activities relationship between consumer and producer are not only giving advantage but also emerge the conflict. The study conducted to observe bilateral relationship between them that the conflict could not resolve by unlitigation way. The method used case study and analyze descriptively through the process and applicable procedure. The result showed that customer reported the problem in order to resolve at Consumer Conflict Resolve Institution against Developer. Resolving litigatively by lowsuit civil action to Distric Court was not accommodative due to complicated beaurocration and case process took long time. Therefore, issuance of laws Number 8, 1999 aabout Consumer Protection hopely could be solution in facilitating Consumers’ complain that have disadvantage by developer to file the complain to Consumer Conflict Resolve Institution by non-litigatitio way. Key words: Conflict, Cunsumer, Developer
APA, Harvard, Vancouver, ISO, and other styles
23

Rahmatullah, Daeng, and Belly Yan Dewantara. "Optimasi DOCR Pada Sistem Distribusi Loop dengan Pembangkit Tersebar Menggunakan Algoritma Modified Particle Swarm Optimastion (MPSO)." Jurnal Elektronika, Listrik, Telekomunikasi, Komputer, Informatika, Sistem Kontrol (J-Eltrik) 1, no. 1 (2019). http://dx.doi.org/10.30649/je.v1i1.10.

Full text
Abstract:
<em>To design the coordination of protection on radial systems is not difficult, but the loop system is challenging for researchers, plus loop systems connected with distributed generators (DG). For setting up Directional Overcurent Relay (DOCR) in loop system only use lowset, so the operating time of release depends on rated of fault current. The fault current will vary if there is DG in the system. Change ON/ OFF DG will also make the direction of the current fluctuate. So we have to reset the protection relay. To re-setting the protection system researchers need more time. The Modified Particle Swarm Optimation (MPSO) method is recommended to reduce the calculation time of the protection relay and obtain the most optimum protection time in loop system with DG. Full load ampere (IFLA) equipment and Maximum fault current (Isc max) as inputs MPSO and lowset as outputs MPSO. Lowset output of MPSO then put on rele as setting DOCR. The results of this study have been tested in simulation using ETAP software successfully and it is clear that MPSO method is the right method to obtain the release settings with the most optimum time.</em>
APA, Harvard, Vancouver, ISO, and other styles
24

Hengist, Aaron, Russell G. Davies, Peter J. Rogers, et al. "Restricting sugar or carbohydrate intake does not impact physical activity level or energy intake over 24 h despite changes in substrate use: a randomised crossover study in healthy men and women." European Journal of Nutrition, November 3, 2022. http://dx.doi.org/10.1007/s00394-022-03048-x.

Full text
Abstract:
Abstract Purpose To determine the effects of dietary sugar or carbohydrate restriction on physical activity energy expenditure, energy intake, and physiological outcomes across 24 h. Methods In a randomized, open-label crossover design, twenty-five healthy men (n = 10) and women (n = 15) consumed three diets over a 24-h period: moderate carbohydrate and sugar content (MODSUG = 50% carbohydrate [20% sugars], 15% protein, 35% fat); low sugar content (LOWSUG = 50% carbohydrate [< 5% sugars], 15% protein, 35% fat); and low carbohydrate content (LOWCHO = 8% carbohydrate [< 5% sugars], 15% protein, 77% fat). Postprandial metabolic responses to a prescribed breakfast (20% EI) were monitored under laboratory conditions before an ad libitum test lunch, with subsequent diet and physical activity monitoring under free-living conditions until blood sample collection the following morning. Results The MODSUG, LOWSUG and LOWCHO diets resulted in similar mean [95%CI] rates of both physical activity energy expenditure (771 [624, 919] vs. 677 [565, 789] vs. 802 [614, 991] kcal·d−1; p = 0.29] and energy intake (2071 [1794, 2347] vs. 2195 [1918, 2473] vs. 2194 [1890, 2498] kcal·d−1; P = 0.34), respectively. The LOWCHO condition elicited the lowest glycaemic and insulinaemic responses to breakfast (P < 0.01) but the highest 24-h increase in LDL-cholesterol concentrations (P < 0.001), with no differences between the MODSUG and LOWSUG treatments. Leptin concentrations decreased over 24-h of consuming LOWCHO relative to LOWSUG (p < 0.01). Conclusion When energy density is controlled for, restricting either sugar or total dietary carbohydrate does not modulate physical activity level or energy intake over a 24-h period (~ 19-h free-living) despite substantial metabolic changes. Clinical trials registration ID NCT03509610, https://clinicaltrials.gov/show/NCT03509610
APA, Harvard, Vancouver, ISO, and other styles
25

Takei, Naoya, Ryuji Muraki, Olivier Girard, and Hideo Hatta. "Inter-individual variability in peripheral oxygen saturation and repeated sprint performance in hypoxia: an observational study of highly-trained subjects." Frontiers in Sports and Active Living 6 (August 8, 2024). http://dx.doi.org/10.3389/fspor.2024.1452541.

Full text
Abstract:
Individual variations in peripheral oxygen saturation (SpO2) during repeated sprints in hypoxia and their impact on exercise performance remain unclear despite fixed external hypoxic stimuli (inspired oxygen fraction: FiO2). This study examined SpO2 individual variations during repeated sprints in hypoxia and their impact on exercise performance. Thirteen highly-trained sprint runners performed 10 × 10-s cycle sprints with 30-s passive recoveries in normobaric hypoxia (FiO2: 0.150). Mean power output (MPO), post-sprint SpO2, and heart rate for each sprint were assessed. Sprint decrement score (Sdec), evaluating fatigue development, was calculated using MPO variables. Participants were categorized into a high saturation group (HiSat, n = 7) or a low saturation group (LowSat, n = 6) based on their mean post-sprint SpO2 (measured 10–15 s after each sprint). Individual mean post-sprint SpO2 ranged from 91.6% to 82.2%. Mean post-sprint SpO2 was significantly higher (P < 0.001, d = 1.54) in HiSat (89.1% ± 1.5%) than LowSat (84.7% ± 1.6%). A significantly larger decrease in Sdec (P = 0.008, d = 1.68) occurred in LowSat (−22.3% ± 2.3%) compared to HiSat (−17.9% ± 2.5%). MPO (P = 0.342 d = 0.55) and heart rate (P = 0.225 d = 0.67) did not differ between groups. There was a significant correlation (r = 0.61; P = 0.028) between SpO2 and Sdec. In highly-trained sprint runners, individual responses to hypoxia varied widely and significantly affected repeated sprint ability, with greater decreases in SpO2 associated with larger performance alterations (i.e., larger decrease in Sdec).
APA, Harvard, Vancouver, ISO, and other styles
26

Chan, Alex, Shandell Elmer, Masuma Khanam, and Leigh Kinsman. "An integrative review: adherence barriers to a lowsalt diet in culturally diverse heart failure adults." Australian Journal of Advanced Nursing 36, no. 1 (2018). http://dx.doi.org/10.37464/2018.361.1448.

Full text
Abstract:
Objective: A sodium restricted diet (SRD) is generally included in chronic heart failure (HF) management. The objective of this review is to explore and synthesise the research findings of the adherence barriers to a SRD in adults from culturally and linguistically diverse (CALD) backgrounds with HF. Setting: The principle research question addressed in this review is: what are the adherence barriers to a SRD for chronic heart failure management in adults from CALD backgrounds? Primary argument: Patient education plays an important role in health decision-making but it is only one of the many factors in dietary sodium restriction adherence. In order to promote the adherence behaviours among the adults with HF, nurses should develop a tailored approach to overcome individuals’ perceived barriers and circumstances especially adults from CALD backgrounds. Results: The literature search was undertaken in PubMed, CINAHL and MEDLINE. After eliminating duplicates and applying the selection criteria, eleven titles were included in the review. Conclusion: This review found three major perceived barriers for adults living with HF to adhere to a SRD from CALD backgrounds: 1) lack of sufficient, appropriate provision of patient education; 2) the levels of interference with social and family life; and 3) the availability and affordability of healthier food alternatives. These barriers are critical to the design of nursing interventions for promoting adherence behaviours. Lack of published research in adults from CALD ethnic minority groups living with HF in Western countries limited the ability to explore all of the barriers identified in this review.
APA, Harvard, Vancouver, ISO, and other styles
27

Katayama-Yoshida, H., and Alex Zunger. "Electronic and Magnetic Properties of Interstitial 3d Impurities in Silicon." MRS Proceedings 46 (1985). http://dx.doi.org/10.1557/proc-46-111.

Full text
Abstract:
AbstractSelf-consistent spin-unrestricted all-electron Green's function calculations are reported for the first time for a series of interstitial 3d impurities in silicon. The calculations, performed within the selfinteraction- corrected local-spin-density fromalism show: (i) not all 3d impurities follow Hund's rule: Tio, Ti−, Vo, V+ and Co2+ have a low-spin ground state, (ii) the angular momentum part gL of g-value is quenched due to p-d hybridization effects, (iii) covalency explains also the chemical trends in the central hyperfine coupling constants, (iii) chemical trends in donor andacceptor transitions are reproduced and are consistent with a high-spin to lowspin transition at the low-Z end and high-Z end of the 3d series, (iv) A number of predictions are offered.
APA, Harvard, Vancouver, ISO, and other styles
28

Cavendish, Philip. "The Cinema of Krzysztof Kieślowski: Variations on Destiny and Chance by Marek s> Haltof (review)." Slavonic and East European Review 84, no. 1 (2006). http://dx.doi.org/10.1353/see.2006.0133.

Full text
APA, Harvard, Vancouver, ISO, and other styles
29

McMahon, Emma J., Judith D. Bauer, Carmel M. Hawley, et al. "The effect of lowering salt intake on ambulatory blood pressure to reduce cardiovascular risk in chronic kidney disease (LowSALT CKD study): protocol of a randomized trial." BMC Nephrology 13, no. 1 (2012). http://dx.doi.org/10.1186/1471-2369-13-137.

Full text
APA, Harvard, Vancouver, ISO, and other styles
30

Michalewicz, Marek, Piotr Lukasz Orlowski, and Yufean Deng. "Creating interconnect topologies by algorithmic edge removal: MOD and SMOD graphs." January 31, 2015. https://doi.org/10.14529/jsfi150402.

Full text
Abstract:
We introduce a method of constructing classes of graphs by algorithmic removal of entire groups of edges. Our approach to creating new classes of graphs is to focus entirely on the structure and properties of the adjacency matrix. At an initialisation step of the algorithm we start with a complete (fully connected) graph. In Part I we present MOD and arrested MOD graphs resulting from removal of square blocks of edges at each iteration and substitution of removed blocks with a diagonal matrix with one extra pivotal element along the main diagonal. The MOD graphs possess unique and useful properties. All important graph measures are easily expressed in analytical form and are presented in the paper. Several important properties of MOD graphs compare very favourably with graphs representing common interconnect topologies: hypercube, 3D and 5D tori, TOFU and dragony. This lead us to consider MOD and arrested MOD graphs as interesting candidats for effective supercomputer interconnects. In Part II, at each iterative step we successively remove triangular shapes from adjacency matrix. This iterative process leads to the nal matrix which has two Sierpinski gaskets aligned along the main diagonal. It will be shown below, that this new class of graphs is not a Sierpinski graph, since it is the adjacency matrix which has a structure of a Sierpinski gasket, and not a graph described by this matrix. We call this new class of graphs Sierpinski-Michalewicz-Or lowski-Deng (SMOD) graphs. The most remarkable property of the SMOD class of graphs, is that irrespective of the graph order, the diameter is constant and equals 2. The size of the graph, or the total number of edges, is about 10% of the size of a complete graph of the same order. We analyse important graph theoretic characteristics related to the topology such as diameter as a function of graph order, size, mean path length, ratio of the graph size to the size of a complete graph of the same order, and some spectral properties. Keywords: supercomputer interconnects, big data, exascale computing, graph theory, topology of graphs, classes of graphs, graph generation.
APA, Harvard, Vancouver, ISO, and other styles
31

Wecht, Jill Maria, Joseph P. Weir, Nguyen Nhuquynh, Gregory J. Schilero, and William A. Bauman. "Heart rate and blood pressure responses to head‐up tilt following autonomic blockade in persons with SCI and intact controls." FASEB Journal 31, S1 (2017). http://dx.doi.org/10.1096/fasebj.31.1_supplement.1077.8.

Full text
Abstract:
ObjectiveTo determine the contribution of cholinergic withdrawal and adrenergic activation on the heart rate (HR) and systolic blood pressure (SBP) responses to head‐up tilt (HUT) in persons with spinal cord injury (SCI), categorized by the level of sympathetic cardiac innervation.Participants/methodsFifteen individuals with chronic SCI (13±12years) and 13 age‐matched controls (41±11 vs. 38±12 years, respectively) participated in the study; the SCI group included 8 individuals with high cord lesions (HIGH: C4‐T3) and 7 individuals with low cord lesions (LOW: T5‐L2). All subjects underwent a HUT maneuver to 70° following randomized‐blinded IV administration of: 1) placebo (NS: normal saline), 2) an anticholinergic agent (AntiCh: glycopyrrolate [0.4 mg/kg])and 3) glycopyrrolate in combination with a selective beta‐1 antagonist (AntiCh + BB: glycopyrrolate + esmolol [1.0 mg/kg + maintenance dose of 50 mcg/kg/min]) on separate laboratory visits. We hypothesized that the increase in HR during HUT would be augmented following administration of AntiCh compared to placebo in all 3 groups, and that this response would be attenuated with AntiCh + BB in the controls and individuals with LOW SCI, but not in those with HIGH SCI. Further, the change in SBP with HUT would not be significantly altered by autonomic cardiac blockade, regardless of group.DesignSupine inter‐beat‐interval (IBI msec) of HR (Impedance Pneumograph, model RESP 1: UFI) and beat‐to‐beat SBP, assessed at the finger arteriole using photoplethysmography (Finometer PRO, Finapres Medical Systems B.V.), were recorded for 5 minutes prior to administration of the study drugs. The HUT maneuver was initiated 7 minutes after drug infusion and IBI and SBP were recorded continuously for 5‐minutes in the HUT position. General linear models (SPSS Version 21.0; IBM Corporation) were constructed to determine significant main (group and drug) and interaction (group × drug) effects for the change in average IBI and SBP from the supine to the HUT position.ResultsThe interaction effect for IBI was not significant (p=0.71) reflecting a similar pattern of response among the groups across the three drug conditions. As expected, the main effect for drug was significant (p<0.001, partial eta^2 = 0.53). Subsequent Bonferroni corrected pairwise comparisons indicate a significant increase in HR compared to placebo (10±9 bpm) with AntiCh (33±15 bpm; p<0.0001), which was attenuated by AntiCh + BB (22±11 bpm; p<0.0001). The interaction effect was marginally significant for SBP (p=0.053); therefore, we performed separate analyses to compare each drugs' effect on the SBP response to HUT among the groups. There were no group differences for the change in SBP following placebo or AntiCh administration; however, Tukey post hoc analyses demonstrated a significantly augmented fall in orthostatic SBP following AntiCh + BB administration in the HIGH SCI group (−28.6±28.1 mmHg) compared to the control(5.7±21.5 mmHg; p<0.01) and LOW SCI (−4.3±17.2 mmHg; p<0.05) groups.ConclusionContrary to our hypothesis, we report a similar IBI response to placebo, AntiCh and AntiCh + BB among the groups, suggesting active cholinergic and adrenergic influences on HR during HUT, regardless of the level of SCI. The differential effect of AntiCh + BB on SBP in those with HIGH SCI compared to controls and LOWSCI suggests cardiac cholinergic and adrenergic influences may be important in the maintenance of orthostatic SBP in individuals with lesions above T4.Support or Funding InformationVA RR&D Service grant # B9212C
APA, Harvard, Vancouver, ISO, and other styles
32

Ruiz, Jiménez Juan. "Pleito del ministril Lope del Castillo contra Diego Hurtado de Mendoza y de la Cerda, II conde de Mélito (1544-1546)." Paisajes sonoros históricos (c.1200-c.1800), December 16, 2023. https://doi.org/10.5281/zenodo.10395287.

Full text
Abstract:
Un pleito entablado por el ministril Lope del Castillo contra el que había sido su patrón, Diego Hurtado de Mendoza y de la Cerda (c. 1516-1578), II conde de Mélito, en 1544, nos acerca a las condiciones con las que estos instrumentistas se concertaban con la nobleza titulada de la época y a los entresijos de los largos y sinuosos litigios judiciales. A lawsuit brought by the minstrel Lope del Castillo against his former patron, Diego Hurtado de Mendoza y de la Cerda (c. 1516-1578), II Count of Mélito, in 1544, gives us an insight into the conditions under which these instrumentalists came to terms with the nobility of the time and to the intricacies of long and winding court litigation.
APA, Harvard, Vancouver, ISO, and other styles
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!