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Journal articles on the topic 'LPO level and AOS activity indices'

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Published: 3 June 2025

Last updated: 31 July 2025

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1

Popov, М. М., S. G. Malanchuck, and М. М. Mishina. "METABOLIC PECULIARITIES AT EXPERIMENTAL GENERALIZED PROCESS CAUSED BY PSEUDOMONAS AERUGINOSA." Annals of Mechnikov Institute, no. 2 (June 7, 2017): 34–38. https://doi.org/10.5281/zenodo.803860.

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System of free radical oxidation is a non-specific link of most of pathologic processes formation in organism. Enzimological studies allowing the definition of both organospecific violations and the state of biological membranes are of great interest in complex approach to the estimation of structural and metabolic peculiarities of organism in conditions of inflammatory pathology. Thus the purpose of the given study is the definition of metabolic state peculiarities at experimental generalized process caused by <em>Pseudomonas aeruginosa</em><em>.</em> According to the results of the carried o

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Н.Г., Стрижельчик, та Яковлєва Л.В. "ОЦІНКА ВПЛИВУ ЛАЗЕРНОГО ВИПРОМІНЮВАННЯ НА РІВЕНЬ ІНТЕНСИВНОСТІ ПРОЦЕСІВ АНТИОКСИДАНТНОГО ЗАХИСТУ В СИРОВАТЦІ КРОВІ ЩУРІВ В УМОВАХ ОКИСЛЮВАЛЬНОГО СТРЕСУ, ІНДУКОВАНОГО ЦИКЛОФОСФАМІДОМ". Біологія та валеологія, № 19 (12 грудня 2017): 93–97. https://doi.org/10.5281/zenodo.1108579.

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Еxperimental studies of the potential modifying properties of low-power laser radiation have shown that, firstly, introduction of cyclophosphamide in rats intraperitoneally for 4 days at the dose of 20 mg/kg is accompanied by the sharp increase in the level of LPO products and the decrease in the level of intensity of AOS processes. The blood serum of rats increased MDA content by 79%, and the level of reduced glutathione and catalase activity were reduced by 55.2% and 41.3%, respectively. The use of red laser radiation with the wavelength of 655 nm of low power before the introduction of muta

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Dolzhykova, Olena, and Ludmila Maloshtan. "THE INFLUENCE OF VAGINAL SUPPOSITORIES “MELANIZOL” ON THE SYSTEM OF LPO-AOS IN CONDITION OF MODEL OF A NONSPECIFIC VAGINITIS IN RATS." EUREKA: Health Sciences 5 (September 20, 2019): 21–27. http://dx.doi.org/10.21303/2504-5679.2019.00998.

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It is known that almost any pathology is accompanied by an imbalance of the lipid peroxidation (LPO) and the antioxidant system (AOS), and diseases of the female reproductive system are no exception. Thus, modern therapies of nonspecific vaginitis (NV) should include drugs with an antioxidant effect in the complex treatment, because the role of the LPO-AOS system in the mechanism for the development of NV is great. This problem can be solved by new complex drug with plant material with a wide spectrum of action. Aim. The aim of our research was to study the effect of new vaginal suppositories

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Bulion, V. V., E. N. Selina, and I. B. Krylova. "Protective effect of uridine on metabolic processes in rat myocardum during its ischemia/reperfusion damage." Biomeditsinskaya Khimiya 65, no. 5 (2019): 398–402. http://dx.doi.org/10.18097/pbmc20196505398.

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The experimental study of the cardioprotective effect of uridine, the metabolic precursor of the endogenous activator of mitochondrial ATP-dependent K+-channels (mitoKATP-channels), was performed using the model of myocardial ischemia/reperfusion (I/RP) in rats. Ischemia for 30 min followed by reperfusion for 120 min resulted in a significant decrease in ATP and phosphocreatine (PC) content, intensification of lipid peroxidation (LPO), and inhibition of the antioxidant system (AOS) in cardiomyocytes. Uridine in a dose of 30 mg/kg, administered intravenously prior to reperfusion, had a protecti

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Sultanov, D. D., O. Nematzoda, A. Sh Shokhsavorbekov, R. K. Davlatov, H. A. Yunusov, and S. G. Ali-Zade. "Endogenous intoxication, oxidative stress and antioxidant system in acute lower limb ischemia." Health care of Tajikistan, no. 4 (February 18, 2023): 91–100. http://dx.doi.org/10.52888/0514-2515-2022-355-4-91-100.

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Aim. To study features of endogenous intoxication syndrome (EI), oxidative stress (LPO) and antioxidant defence (AOS) in patients with acute lower limb ischemia (LLI).Materials and methods. Some parameters of EI, LPO and AOS were studied. EI syndrome was studied in 86 patients with LLI who underwent complex examination and treatment in 2020-2021 in the Department of Vascular Surgery of the RNCfCS. POL and AOS parameters were studied in 14 patients out of 86. There were 51 (59.3%) men and 35 (40.7%) women, mean age was 56.0±5.8 years. Acute occlusion of the iliofemoral segments was noted in 33

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Olena, Dolzhykova, and Maloshtan Ludmila. "THE INFLUENCE OF VAGINAL SUPPOSITORIES "MELANIZOL" ON THE SYSTEM OF LPO-AOS IN CONDITION OF MODEL OF A NONSPECIFIC VAGINITIS IN RATS." EUREKA: Health Sciences 5 (September 30, 2019): 21–27. https://doi.org/10.21303/2504-5679.2019.00998.

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It is known that almost any pathology is accompanied by an imbalance of the lipid peroxidation (LPO) and the antioxidant system (AOS), and diseases of the female reproductive system are no exception. Thus, modern therapies of nonspecific vaginitis (NV) should include drugs with an antioxidant effect in the complex treatment, because the role of the LPO-AOS system in the mechanism for the development of NV is great. This problem can be solved by new complex drug with plant material with a wide spectrum of action. <strong>Aim.</strong> The aim of our research was to study the effect of new

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7

Stankevych, Liudmyla, Iryna Zemtsova, and Yuliia Khmelnytska. "Screening of the AO capacity of triathletes' blood in vitro." Scientific Journal of National Pedagogical Dragomanov University Series 15 Scientific and pedagogical problems of physical culture (physical culture and sports), no. 3K(188) (March 21, 2025): 284–88. https://doi.org/10.31392/udu-nc.series15.2025.03k(188).66.

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One of the types of biochemical reserves of the human body is the antioxidant system, which reverses the destructive effect of free radicals and keeps the level of lipid peroxidation (LPO) within physiologically safe limits [1; 5]. Since the level of lipid peroxidation is determined, on the one hand, by the processes of radical and peroxide formation, and, on the other hand, by the state of endogenous antioxidant activity systems (AOS), the assessment of the activity of these systems is of practical importance [3]. Objective: To determine the total antioxidant activity of blood of triathlon at

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Tetiana, Kalynychenko. "Prognostic assessment of cryosensitivity level for umbilical cord blood hemopoietic tissue with the help of markers of prooxidant activity processes." ScienceRise: Medical Science, no. 5(25) (September 28, 2018): 52–58. https://doi.org/10.15587/2519-4798.2018.138222.

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<strong>Aim.</strong> To investigate the connection between the levels of human umbilical cord blood hemopoietic tissue (UCB HT) cryosensitivity (using of the granulocyte-macrophage progenitors (GMPs) percentage loss) and activity of prooxidant processes in whole blood before the beginning of its cryopreservation. <strong>Methods of research.</strong> Cryopreservation of UCB nuclear cell fraction was carried out by slow freezing under protection of the dimethyl sulfoxide in 5% final concentration (v/v). The loss of GMPs was determined by the difference in the total content of colonie

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Popova, TA, II Prokofiev, IS Mokrousov, et al. "Effects of Neuroactive Amino Acids Derivatives on Cardiac and Cerebral Mitochondria and Endothelial functions in Animals Exposed to Stress." Journal of Clinical and Health Sciences 2, no. 2 (2017): 34. http://dx.doi.org/10.24191/jchs.v2i2.5885.

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Introduction: To study the effects of glufimet, a new derivative of glutamic acid, and phenibut, a derivative of γ-aminobutyric acid (GABA), on cardiac and cerebral mitochondria and endothelial functions in animals following exposure to stress and inducible nitric oxide synthase (iNOS) inhibition. Methods: Rats suspended by their dorsal cervical skin fold for 24 hours served as the immobilization and pain stress model. Arterial blood pressure was determined using a non-invasive blood pressure monitor. Mitochondrial fraction of heart and brain homogenates were isolated by differential centrifug

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Abdullozoda, J. A., I. Gadoev, and M. H. Nabiev. "Significance of oxidative endotoxemia and hypoxia in the pathogenesis of testicular insufficiency in patients with inguinal hernia." Health care of Tajikistan, no. 3 (November 12, 2022): 5–11. http://dx.doi.org/10.52888/0514-2515-2022-354-3-5-11.

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Aim. To determine the level of “oxidative stress” and hypoxia markers in the blood and venous blood flowing from the testicle in inguinal hernias and the postoperative period after inguinal hernioplasty.Materials and Methods. 34 patients with inguinal hernias were under the observation in Istiqlol health complex of Dushanbe. The age of patients ranged from 18 to 30 years old. The patients were divided into 3 groups: 14 patients with long (5 or more years) inguinal hernia combined with varicocele, 12 patients with infertility, and 8 patients with inguinal herniotomy. The content of LPO products

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Potskhveriya, М. М., A. K. Evseev, A. Yu Simonova, et al. "INTERRELATION OF PLATINUM ELECTRODE OPEN CIRCUIT POTENTIAL IN THE BLOOD PLASMA AND OXIDATIVE STRESS COEFFICIENT IN PATIENTS WITH ACUTE POISONING BY CAUTERANT AGENTS." Toxicological Review, no. 2 (April 28, 2018): 7–12. http://dx.doi.org/10.36946/0869-7922-2018-2-7-12.

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The relationship between the platinum electrode open circuit potential (OCP) in the blood plasma as an integral indicator of the balance of oxidation-reduction processes in the body with an oxidative stress coefficient (K) reflecting the balance of the lipid peroxidation and state of antioxidant system (LPO/AOS) in patients with acute poisoning by cauterant agents was investigated. The platinum electrode OCP in the blood plasma was measured using an original electrochemical technique. The oxidative stress coefficient was determined from the ratio of the malondialdehyde level to the total antio

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Oleg, Loskutov, and Druzhyna Oleksandr. "Impact of General Anesthesia on the Activity of Lipids Peroxidase Oxidation During Cardiac Surgery for Elderly Patients." Journal of Progressive Research in Chemistry 2, no. 2 (2015): 92–96. https://doi.org/10.5281/zenodo.3969991.

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This paper examines lipid peroxidation (LPO) dynamics and antioxidant system(AOS) values in 43 patients (aged 69,11 ± 1,99, with the weight of 83.7 ± 1.15 kg) during coronary artery bypass graft (CABG) surgery with cardiopulmonary bypass (CPB). The use of propofol resulted in the increase of diene conjugates number (DC) by 17.1 ± 0,40% on the background of higher values of malondialdehyde (MDA) 18.4 ± 1,08% relative to previous values. While with the use of sevoflurane an increase of DC level by 30.1 ± 1,88% on the background of MDA decrease by 19,03 ±

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Н.Г., Стрижельчик, та Яковлєва Л.В. "ДОСЛІДЖЕННЯ ВПЛИВУ ЛАЗЕРНОГО ВИПРОМІНЮВАННЯ НА РІВЕНЬ ІНТЕНСИВНОСТІ ПРОЦЕСІВ АНТИОКСИДАНТНОГО ЗАХИСТУ В СИРОВАТЦІ КРОВІ ЩУРІВ В УМОВАХ ОКИСЛЮВАЛЬНОГО СТРЕСУ, ІНДУКОВАНОГО ДІОКСИДИНОМ". Біологія та валеологія, № 19 (12 грудня 2017): 87–92. https://doi.org/10.5281/zenodo.1108573.

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The influence of low power laser radiation on intensity level of antioxidant system processes and the lipid peroxidation in rat blood serum at oxidative stress conditions induced by dioxidine medicine has been studied. Itravenous administration of mammalian pro-oxidant mutagens is accompanied by a sharp increase in the production of active oxygen metabolites and the initiation of lipid peroxidation processes. There is the increase in the products of LPG (by 63%) and the decrease in the intensity of AOP processes (by 39%). As a result of the use of laser radiation, the intensification of AOS pr

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Ashafaq, Mohammad, Sohail Hussain, Saeed Alshahrani, et al. "Neuroprotective Effects of Nano-Curcumin against Cypermethrin Associated Oxidative Stress and Up-Regulation of Apoptotic and Inflammatory Gene Expression in Rat Brains." Antioxidants 12, no. 3 (2023): 644. http://dx.doi.org/10.3390/antiox12030644.

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Cypermethrin (CPM) is the most toxic synthetic pyrethroid that has established neurotoxicity through oxidative stress and neurochemical agitation in experimental rats. The toxic effects are supposed to be mediated by modifying the sodium channels, reducing Na-K ATPase, acetylcholine esterase (AchE), and monoamine oxidase (MAO). The use of curcumin nanoparticles (NC) that have potent antioxidant, anti-inflammatory and antiapoptotic properties with improved bioavailability attenuates neurotoxicity in rat brains. To test this hypothesis, animals were divided into five groups, each having six anim

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Mokrii, V. Y., S. V. Ziablytsev, and M. V. Cryshtal. "THE VALUE OF POLYMORPHISM RRO12ALA GENE PPARG IN VIOLATION OF LIPID PEROXIDATION AND ANTIOXIDANT PROTECTION IN PATIENTS WITH TYPE 2 DIABETES." Ukrainian Scientific Medical Youth Journal, no. 4(98) (December 14, 2016): 5–9. http://dx.doi.org/10.32345/usmyj.4(98)().2016.5-9.

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Resume. The incidence of type 2 diabetes is increasing in Ukraine and worldwide. The severity of this disease is determined by the number of complications, which are based on lipid peroxidation (LPO). Today, the influence of gene polymorphisms Pro12Ala PPARG on oxidative and antioxidant processes is not in doubt. We studied the association between gene polymorphism Pro12Ala rs1801282 PPARG and intensification of lipid peroxidation and antioxidant systems (AOS) in 88 patients with type 2 diabetes, using analysis of variance. In the 12Pro allele carriers male found probable increased intensifica

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Semizidis, A. T., N. E. Manturova, and L. S. Kruglova. "Complex application of high-intensity phototechnologies in the treatment of melasma." Fizioterapevt (Physiotherapist), no. 5 (November 12, 2024): 81–87. http://dx.doi.org/10.33920/med-14-2405-10.

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Purpose of the study. In clinical practice, combined methods, as a rule, show better efficiency in the treatment of melasma than monotherapy. Also relevant are the issues of studying the efficiency and safety of various combinations of hardware and drug methods. The aim of the study was to optimize the treatment of patients with melasma using the complex use of high-intensity phototechnologies (IPL therapy, Nd: YAG laser) and thiamidol, taking into account the indicators of oxidative stress. Materials and methods. All patients were divided into 4 groups, depending on the methods of therapy. Li

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Akarah, E. O. "Effects of Gender and Aerobic Exercise on Oxidative Stress and Haematological Parameters of Students of Physical Education." Journal of Applied Sciences and Environmental Management 25, no. 4 (2021): 523–27. http://dx.doi.org/10.4314/jasem.v25i4.5.

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The present study examined the effects of sex differences and aerobic exercise on oxidative stress and haematological parameters. The study had participants who were between 19- 20 years and consisted of 15 male and 15 female students of Physical Education in Delta State University, Abraka. The students were made to undergo rigorous aerobic exercise which involved running at an average speed of about 10 Kilometres / hour for about 1 hour and 20 mins. Blood Sample was taken from each student before and after the aerobic exercise and used for analysis. The plasma superoxide dismutase (SOD) activ

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Ommati, Mohammad Mehdi, Omid Farshad, Vahid Ghanbarinejad, et al. "The Nephroprotective Role of Carnosine Against Ifosfamide-Induced Renal Injury and Electrolytes Imbalance is Mediated Via the Regulation of Mitochondrial Function and Alleviation of Oxidative Stress." Drug Research 70, no. 01 (2019): 49–56. http://dx.doi.org/10.1055/a-1017-5085.

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Abstract Background Ifosfamide (IFO) is an alkylating agent administered against different types of malignancies. Several cases of renal injury and serum electrolytes disturbances have been reported in IFO-treated patients. Oxidative stress and mitochondrial dysfunction are suspected of being involved in the mechanism of IFO nephrotoxicity. Carnosine is a dipeptide which its antioxidant and mitochondria protecting properties have been mentioned in different experimental models. The current study aimed to evaluate the nephroprotective properties of carnosine against IFO-induced renal injury. Me

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Zhukova, I. O., N. O. Bazdyreva та N. I. Longus. "Вплив маклеї серцевидної на стан системи антиоксидантного захисту організму качок за дегельмінтизації фенбендазолом". Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies 19, № 73 (2017): 40–45. http://dx.doi.org/10.15421/nvlvet7309.

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The use of biological products ecologically safe for human and animals is the key to improve the quality of life. The replacement of synthetic antibiotics, hormone stimulants and other hazardous chemical drugs by natural substances of plant origin is an effective step to decrease gastrointestinal disorders and to improve the indices of growth and development of various species of animals. The beneficial effect of the above drugs can be explained by the potential of these substances to maintain beneficial microflora of gastrointestinal tract that protects the animal from pathogenic bacteria and

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Reznichenko, N. Yu, Yu G. Reznichenko, Ya O. Yemchenko, et al. "New possibilities for treating patients with acne vulgaris." Ukrainian Journal of Dermatology, Venerology, Cosmetology, no. 2 (June 26, 2025): 33–48. https://doi.org/10.30978/ujdvk2025-2-33.

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Objective — to study the effectiveness of treatment and quality of life of patients with acne vulgaris with the additional use of a special complex in complex therapy. Materials and methods. 382 patients with acne vulgaris aged 18 to 30 years were under observation, who were divided into two groups: control group I —123 patients who received standard complex therapy for three months and did not receive treatment for the next 3 months; experimental (test) group II — 259 patients who received standard complex therapy and additionally the special complex Alpenta. Group II was divided into two sub

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Kazatseva, K. V., S. N. Nagornev, V. K. Frolkov, and E. V. Gusakova. "The dynamics of indicators of peroxide metabolism in patients with cicatricial skin deformations in combination with metabolic syndrome in complex use of physiotherapeutic treatment methods and drinking mineral waters." Fizioterapevt (Physiotherapist), no. 2 (February 1, 2021): 45–55. http://dx.doi.org/10.33920/med-14-2104-06.

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The article analyzes the role of lipid peroxidation processes in the pathogenesis of cicatricial skin changes, including in patients with metabolic syndrome. Baseline indices of LPO processes and antioxidant enzymes in patients with metabolic syndrome indicate the development of oxidative stress and accumulation of cytotoxic carbonyl products. The course use of a combination of fermenkol phonophoresis, fractional photothermolysis and mineral water «Essentuki №17» in patients with cicatricial changes in the skin and metabolic syndrome is accompanied by a decrease in the severity of insulin resi

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Kosilova, Svitlana. "INFLUENCE OF PERIPHERAL STRESS-LIMITING SYSTEM DISORDERS ON THE COURSE OF PREGNANCY IN WOMEN WITH PREECLAMPSIA." Clinical anatomy and operative surgery 23, no. 2 (2024): 42–48. http://dx.doi.org/10.24061/1727-0847.23.2.2024.27.

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The aim of research. To study the eﬀ ect of peripheral stress- limiting system disorders on the course of pregnancy in women with preeclampsia (PE).Material and methods. A clinical and statistical analysis of the course of pregnancy in 34 patients with PE (main group) was performed. Of these, 20 had moderate PE (group I) and 14 had severe PE (group II). The control group consisted of 20 healthy women. Indicators of lipid peroxidation (LPO) and antioxidant system (AOS) protection were studied at 24-26 and 34-36 weeks of pregnancy.Research results. In pregnant women with PE, disturbances in the

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Ruziev, Umid, Khamid Karimov, Larisa Shevchenko, and Timur Alimov. "Effectiveness of the new polyfunctional infusion solution of blood substitutes on the activity of lipid peroxidation and antioxidant protection of heart in acute fatal blood loss." International Journal of Research in Medical Sciences 5, no. 1 (2016): 89. http://dx.doi.org/10.18203/2320-6012.ijrms20164529.

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Background: One of the important directions of modern medicine is improving treatment of extreme conditions, the mortality rate of which is still very high, which is often associated with insufficient effectiveness of modern blood substitutes. Purpose of the study was to investigate the efficacy of a new multifunctional blood substitute in acute fatal blood loss on the activity of lipid peroxidation (LPO) and antioxidant system (AOS) of the heart, which showed its high antioxidant efficiency.Methods: Experiment was carried out on 60 rats weighing 180-200 g, clinical death was caused under etam

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Ismaylov, R. G. "REGULATION OF MELANOGENESIS IN THE DYSCHROMIA OF SKIN." Annals of the Russian academy of medical sciences 69, no. 1-2 (2015): 85–92. http://dx.doi.org/10.15690/vramn.v69.i1-2.948.

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Aim: to examine the role of immune, biochemical and hormonal factors in the regulation of melanogenesis in patients with chromatopathy. Patients and methods: we observed 226 patients with various forms dyschromia skin. Age of the patients was in the range of 16 to 55 years. The frequency of females (n =157) prevailed over the male sex (n =69) 2,3 times. The disease duration ranged from 3 weeks to 12 years. For the study of melanogenesis in vitiligo, nevi and melasma were studied parameters of the immune, endocrine and lipid peroxidation — antioxidant system. Results: melanocytes are responsibl

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Lukatkin, Alexander S., Irina D. Michailova, and Jaime A. Teixeira da Silva. "Prooxidative and antioxidative properties of cucumber (Cucumis sativus L.) callus in vitro and young in vivo plantlets in response to copper ions." Folia Horticulturae 25, no. 2 (2013): 141–51. http://dx.doi.org/10.2478/fhort-2013-0016.

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ABSTRACT The effects of different concentrations of copper ions (Cu2+ in the form of CuSO4 × 5H2O) on in vivo cucumber (Cucumis sativus L. ‘Edinstvo’) seedlings as well as on in vitro hypocotyl-derived callus were considered. Callus induction from hypocotyls was more prolific than from roots or cotyledons. Thus, callus obtained from hypocotyls of 7-day-old cucumber plants was cultured for 5 weeks on Murashige and Skoog medium containing 4 mg dm-3 2,4-D + 1 mg dm-3 BA supplemented with 0.01 mM, 0.1 mM or 1.0 mM of Cu2+. Biochemical indices related to oxidative stress were assessed. Cu2+ at 0.01

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Okassova, Assem K., Valeriy Britko, Didar B. Okassov, et al. "Study of Lipid Peroxidation-antioxidant Defense Systems in Rats under Radiation Exposure." Open Access Macedonian Journal of Medical Sciences 10, A (2022): 236–39. http://dx.doi.org/10.3889/oamjms.2022.8352.

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Abstract BACKGROUND: Experimental data on the effect of a high dose of gamma radiation 6 Gy on the activity of antioxidant defense enzymes and lipid peroxidation products (LPO) are presented immunocompetent organs in the body of animals in the experiment. It was found that the effect of ionizing radiation led to an increase in the level of diene conjugates (DC) and malondialdehyde (MDA), inhibition of the activity of catalase (CАT) and glutathione peroxidase (GlP), glutathione reductase (GlR) enzymes in almost all the studied objects, as a result of which the development of oxidative str

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Nilova, I. A., N. S. Repkina, and N. M. Kaznina. "«Influence of Excess Zinc on the Activity of Components of the Antioxidant System in Brassica juncea L. (Czern.) and Sinapis alba L. Plants»." Физиология растений 70, no. 5 (2023): 506–13. http://dx.doi.org/10.31857/s0015330323600183.

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Under the conditions of a growing experiment, the authors studied the effect of zinc at concentra_x0002_tions of 5 (control), 50, 100, and 150 mg/kg substrate on growth, the intensity of lipid peroxidation (LPO), and the activity of the components of the antioxidant system in Brassica juncea L. (Сzern.) variety Slavyanka and Sinapis alba L. cultivar Belgium plants. Some differences and similarities were found in the AOS response of the studied species to an excess of zinc in the root environment. Thus, there were no changes in the inten_x0002_sity of lipid peroxidation in B. juncea under the i

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Dzugkoev, S. G., F. S. Dzugkoeva, O. I. Margieva, and A. E. Khubulova. "Effects of fabomatisol under lead intoxication in rat experiment." Siberian Journal of Clinical and Experimental Medicine 38, no. 3 (2023): 216–22. http://dx.doi.org/10.29001/2073-8552-2023-39-3-216-222.

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The conducted study indicates the priority use of the drug fabomatizole to protect living systems from the negative effects of lead acetate.Aim: To study the mechanisms of fabomatizole effect on the nature of changes in redox reactions, NO-forming function of the endothelium, cholesterol metabolism and functional parameters in rats with lead intoxication.Material and Methods. The study was carried out on 60 Wistar rats. Lead intoxication was induced by intramuscular administration of lead acetate at a dose of 5 mg/kg of animal weight for a month. At the end of the intoxication period, Fabomati

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Yavtushenko, Ivan V., Svitlana M. Nazarenko, Oleksandr V. Katrushov, and Vitalii O. Kostenko. "QUERCETIN LIMITS THE PROGRESSION OF OXIDATIVE AND NITROSATIVE STRESS IN THE RATS’ TISSUES AFTER EXPERIMENTAL TRAUMATIC BRAIN INJURY." Wiadomości Lekarskie 73, no. 10 (2020): 2127–32. http://dx.doi.org/10.36740/wlek202010104.

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The aim: To investigate the effect of water-soluble form of quercetin on the indices reflecting the progression of oxidative-nitrosative stress in the cerebral tissues and the periodontium of rats after experimental TBI. Materials and methods: The studies were conducted on 30 white rats of the Wistar line weighing 180-220 g, divided into 3 groups: the 1st group included pseudo-injured animals (subjected to ether anaesthesia, fixation without TBI modeling), the 2nd group included the animals exposed to modeled moderate TBI, the 3rd group involved the rats, which were given injections with water

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Zhukova, I. O., Yu S. Svitlychna–Kulak та N. I. Longus. "КОРЕКЦІЯ СТАНУ АНТИОКСИДАНТНОГО ЗАХИСТУ У СОБАК ЗА ОТРУЄННЯ НЕОВЕРМОМ". Scientific Messenger of LNU of Veterinary Medicine and Biotechnology 18, № 3(70) (2016): 95–100. http://dx.doi.org/10.15421/nvlvet7022.

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The data on the impact of the drug «Neoverm» on the dogs have been presented in the article. The drug was administered into the stomach at the dose of 0.6 mg/kg of live weight for three days and the antioxidant drugs «E–Selenium» and «Quercetin» as well as green buckwheat and hepaprotector «L’esphal» as natural antioxidant preparations were used. «Neoverm» is a new antiparasitic drug that belongs to the group of medicines of broad–spectrum of action of the avermectin derivatives.The main active substance is ivermectin (10 mg), it belongsto the group of compounds which are the product of enzymi

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Bachynskyi, Dmytro, and Vasyl Skrypko. "Changes in Endogenous Intoxication and Antioxidant Defense System Markers in Patients with Tumor-Induced Acute Colonic Obstruction." Archive of Clinical Medicine 29, no. 2 (2024): 25–28. http://dx.doi.org/10.21802/acm.2023.2.8.

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A comprehensive evaluation of clinical and biochemical markers defining the status of endotoxemia in patients diagnosed with acute colonic obstruction (ACO) was conducted. The findings revealed that advancing stages of ACO corresponded to an increase in serum levels of endogenous intoxication markers and a simultaneous decrease in antioxidant defense system (ADS) markers. The aim of the study was to analyze changes in endogenous intoxication and ADS markers in patients with tumor-induced ACO throughout the disease progression and evaluate the outcomes. Materials and Methods. The st

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Pavlyuchenko, Ivan I., Evgenii A. Kokov, Lyudmila N. Kokova, and Olga S. Okhremenko. "Influence of the phenotype of the disease on the parameters of the antioxidant defense system and the level of some interleukins in the blood of patients with chronic obstructive pulmonary disease." Pediatrician (St. Petersburg) 8, no. 6 (2017): 38–41. http://dx.doi.org/10.17816/ped8638-41.

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Chronic obstructive pulmonary disease (COPD) is a common disease involving the pathological process, of bronchopulmonary and cardiovascular systems. This is a complex disease in which inflammation plays a leading role in the formation of the whole complex of pathological changes. COPD accompanies local deficit of antiproteases, excessive formation of active forms of oxygen, inducing uncontrolled lipid peroxidation and oxidative stress. An increase in the level of proinflammatory cytokines, such as IL-6, IL-8, TNF-α, is particularly significant in the combination of chronic obstructive disease

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Patalakha, O. V. "The role of endogenous intoxication syndrome and the activity of the antioxidant protection system in the survival of generalized parodontitis in nuclear disease patients with toxic hepatitis." Clinical Dentistry, no. 4 (November 23, 2018): 19–30. http://dx.doi.org/10.11603/2311-9624.2018.4.9631.

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A prominent place in the structure of narcological disorders is opioid drug abuse. It has been detected that in patients with narcotic dependence, especially those who use substances based on opium, have the frequency and severity of oral cavity diseases significantly increased. Within patients with a different narcotic experience, predominantly, manifestations of generalized parodontitis (GP) are observed, with inflammatory-destructive processes in parodontum in drug addicts found in 2.5–10 times more frequent than in the population. The amplification of free radical oxidation of

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Yatskevych, O., O. Abrahamovych, and I. Korniichuk. "Ulcerative Lesions of the Mucosa Gastro-Duodenal Zone in Victims of the Chernobyl Accident: Some Features of the Etiology, Pathogenesis and Clinical Signs Identified in the Third of the Century After the Disaster." Lviv clinical bulletin 3, no. 31 (2020): 25–36. http://dx.doi.org/10.25040/lkv2020.03.025.

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Introduction. The victims of the Chernobyl accident have a significantly higher morbidity compared to the unaffected population. Ulcerative lesions of the gastric and duodenal mucosa are quite common. The aim of the study. To find out some features of ulcerative lesions of the gastroduodenal zone in the victims of the Chernobyl accident based on the analysis of the causes, pathogenesis, clinical signs, conducted in the third of the century after the disaster. Materials and methods. The study involved 115 patients with ulcerative lesions of the gastroduodenal zone. The experimental group (EG) o

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Herasymenko, Svitlana, Iryna Nikitina, and Svetlana Smiian. "CLINICAL PATHOGENETIC SUBSTANTIATION OF THE REGENERATIVE TREATMENT OF PARTURIENTS WHO SUFFERED FROM OBSTETRICAL HAEMORRHAGES." Eastern Ukrainian Medical Journal 11, no. 2 (2023): 136–42. http://dx.doi.org/10.21272/eumj.2023;11(2):136-142.

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The publication is devoted to an urgent problem of modern obstetrics – the study of pathophysiological changes in the organism of parturients after obstetrical haemorrhages, improvement of restorative treatment, as well as reduction of complications in the puerperium and prevention of their occurrence. The aim of the study: to increase the effectiveness of restorative treatment of women in labor who suffered obstetric bleeding by studying the features of the clinical course, mechanisms of pathogenetic disorders, and their correction using ozone therapy. Materials and methods. A comprehensive c

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Adeleke, G. E., O. Q. Owolabi, G. A. Berena, et al. "Chemical characterization of Hymenocardia acida stem bark extract and modulation of selected enzymes in Kidney and Heart of Wistar rats." Medical Research Archives 11, no. 9 (2023). http://dx.doi.org/10.18103/mra.v11i9.4288.

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Hymenocardia acida tul leaf and stem bark are used in treatment of several diseases in Africa. We examined the chemical constituents of the stem bark extract and its effects on some antioxidant indices and esterases in Wistar rats. Hymenocardia acida stem bark extract (HASBE) was obtained by Soxhlet extraction using methanol, followed by Atomic Absorption Spectroscopy (AAS), Fourier-Transform Infrared (FT-IR) spectroscopy, ultraviolet (UV) spectroscopy, High-performance liquid chromatography (HPLC) and Gas Chromatography-Flame ionization detection (GC-FID). Forty-eight male Wistar rats were as

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Li, Qin, Yu-Han Huang, Qiu-Qi Li, et al. "Sodium valproate ablates ferroptosis in kainic acid-induced epileptic seizure via suppressing lysyl oxidase." NeuroReport, October 1, 2024. http://dx.doi.org/10.1097/wnr.0000000000002103.

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The objective of this study is to explore whether sodium valproate (VPA) alleviates epileptic seizures via suppressing lysyl oxidase (Lox)-mediated ferroptosis. Epileptic seizure mouse model was prepared via intrahippocampal injection of kainic acid (250 ng/μl). After treatment with kainic acid, VPA was injected intraperitoneally by the dose of 250 mg/kg twice daily for 4 days. Ferroptosis-associated indices including lipid peroxides (LPO) level and Ptgs2 mRNA in hippocampal tissue samples were detected. Additionally, effects of VPA on Lox mRNA and enzymatic activity were assessed by quantitat

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Kovalska, M. Ye. "Зміни функціонального стану прооксидантної та антиоксидантної систем у надниркових залозах морських свинок за умов формування експериментального алергічного альвеоліту". Medical and Clinical Chemistry, № 4 (11 січня 2018). http://dx.doi.org/10.11603/mcch.2410-681x.2017.v0.i4.8304.

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Introduction. Important role in understanding the pathogenesis of allergic alveolitis is played by processes of lipid peroxidation (LPO) and antioxidant system (AOS). Under physiological conditions, the level of LPO is maintained due to the equilibrium of pro- and antioxidant systems. LPO is considered as a universal mechanism of cell damage at the membrane level in conditions of different pathological conditions. In particular, hypoxia, inflammation, stress, allergy activate lipoperoxidation processes and suppress both an enzymatic and non-enzymatic activity of antioxidant defense. Products o

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Ommati, Mohammad Mehdi, Mohammad Reza Arabnezhad, Omid Farshad, et al. "The Role of Mitochondrial Impairment and Oxidative Stress in the Pathogenesis of Lithium-Induced Reproductive Toxicity in Male Mice." Frontiers in Veterinary Science 8 (March 24, 2021). http://dx.doi.org/10.3389/fvets.2021.603262.

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Lithium (Li+) is prescribed against a wide range of neurological disorders. Besides its excellent therapeutic properties, there are several adverse effects associated with Li+. The impact of Li+ on renal function and diabetes insipidus is the most common adverse effect of this drug. On the other hand, infertility and decreased libido is another complication associated with Li+. It has been found that sperm indices of functionality, as well as libido, is significantly reduced in Li+-treated men. These adverse effects might lead to drug incompliance and the cessation of drug therapy. Hence, the

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Smirnova, Olga, and Natalia Goncharova. "CHARACTERISTICS OF THE BLOOD PLASMA "LIPID PEROXIDATION - ANTIOXIDANT PROTECTION" SYSTEM DEPENDING ON NASAL MUCOSA MICROFLORA COMPOSITION IN VARIOUS CHRONIC RHINITIS PHENOTYPES." Russian Journal of Infection and Immunity, January 16, 2025. https://doi.org/10.15789/2220-7619-cot-17779.

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Abstract Chronic rhinitis is the most common ENT disease. Over the past decade, there has been an increased incidence of chronic rhinitis. In all forms of chronic rhinitis, there is a decrease in the protective properties of nasal mucous membrane, which can be accompanied by activation of nasal bacterial microflora. Dysbiosis of nasal mucous microbiota contributes to the development of inflammation, activation of immune cells with the development of immune reactions, activation of lipid peroxidation processes and changes in the activity of antioxidant defense factors in nasal cavity and blood.

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Ziablytsev, S. V., V. Y. Mokrii, and M. V. Crystal. "The value of polymorphism RRO12ALA gene PPARG in violation of lipid peroxidation and antioxidant protection in patients with type 2 diabetes mellitus." September 29, 2016. https://doi.org/10.5281/zenodo.158861.

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<strong>Ziablytsev S. V., Mokrii V. Y., Crystal M. V. The value of polymorphism RRO12ALA gene PPARG in violation of lipid peroxidation and antioxidant protection in patients with type 2 diabetes mellitus. </strong><strong>Journal of Education, Health and </strong><strong>Sport. 2016;6(9):626-636. eISSN 2391-8306. DOI </strong><strong>http://dx.doi.org/10.5281/zenodo.158861</strong> <strong>http://ojs.ukw.edu.pl/index.php/johs/article/view/3888</strong> <strong>The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23.12.2015).</strong>

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Televiak, A. T., T. O. Veresiuk, P. R. Selskyy, et al. "Dynamic of indices of lipid peroxidation and antioxidant protection in muscular tissue and blood serum of rats with acute ischemia-reperfusion." October 31, 2018. https://doi.org/10.5281/zenodo.1476568.

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Televiak A. T., Veresiuk T. O., Selskyy P. R., Volska A. S., Kurylo K. I., Nebesna Z. M., Datsko T. V., Boymystruk I. I. Dynamic of indices of lipid peroxidation and antioxidant protection in muscular tissue and blood serum of rats with acute ischemia-reperfusion. Journal of Education, Health and Sport. 2018;8(10):245-255. eISNN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.1476568  http://ojs.ukw.edu.pl/index.php/johs/article/view/6248         The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part b item 1223 (26/01/2017

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