Relevant bibliographies by topics / LSCs

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Academic literature on the topic 'LSCs'

Author: Grafiati
Published: 4 June 2021
Last updated: 17 February 2022

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Journal articles on the topic "LSCs"

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Su, X., Y. Liu, M. Bakkar, O. ElKashty, M. El-Hakim, J. Seuntjens, and S. D. Tran. "Labial Stem Cell Extract Mitigates Injury to Irradiated Salivary Glands." Journal of Dental Research 99, no. 3 (January 14, 2020): 293–301. http://dx.doi.org/10.1177/0022034519898138.

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Stem cell–based therapies could provide a permanent treatment for salivary gland (SG) hypofunction caused by ionizing radiation (IR) injury. However, current challenges for SG stem cells to reach the clinic include surgical invasiveness, amount of tissue needed, cell delivery, and storage methods. The objective of this study was to develop a clinically less invasive method to isolate and expand human SG stem cells and then to obtain a cell-free extract to be used as a therapy for IR-injured SGs. Human labial glands were biopsied, and labial stem cells (LSCs) were expanded by explant culture. The LSC extract (LSCE) was obtained by releasing the cellular components after 3 freeze-thaw cycles and 17,000 g force centrifugation. LSCE was injected intravenously into mice that had their SGs injured with 13-Gy IR. Positive (non-IR) and negative (IR) control mice received injections of saline (vehicle control). Three pieces of labial glands (0.1 g weight) could expand 1 to 2 million cells. LSCs had a doubling time of 18.8 h; could differentiate into osteocytes, adipocytes, and chondrocytes; and were positive for mesenchymal stem cell markers. Both angiogenic (FGF-1, FGF-2, KGF, angiopoietin, uPA, VEGF) and antiangiogenic factors (PAI-1, TIMP-1, TSP-1, CD26) were detected in LSCE. In addition, some angiogenic factors (PEDF, PTX3, VEGF) possessed neurotrophic functions. Mice treated with LSCE had 50% to 60% higher salivary flow rate than saline-treated mice at 8 and 12 wk post-IR. Saliva lag time measurements also confirmed that LSCE restored SG function. Histologic analyses of parotids and submandibular glands reported comparable numbers of acinar cells, blood vessels, and parasympathetic nerves and cell proliferation rates in sham IR and LSCE-treated mice, though significantly lower in saline-treated mice. An explant culture method can harvest a large number of LSCs from small pieces of labial glands. LSCE showed clinical potential to mitigate IR-injured SGs.
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Ikezoe, Takayuki, Yang Jing, Chie Nishioka, Shinsuke Kojima, Asako Takeuchi, and Akihito Yokoyama. "Inhibition of STAT5 by IL-1β or the Inhibitor of Janus Kinases Stimulates Dormant Human Leukemia Stem Cells and Sensitizes Them to Anti-Leukemia Agents." Blood 114, no. 22 (November 20, 2009): 1597. http://dx.doi.org/10.1182/blood.v114.22.1597.1597.

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Abstract Abstract 1597 Poster Board I-623 Leukemia stem cells (LSCs) are in a quiescent state, which maybe contributes to their drug-resistant character. It is essential to eradicate LSCs to develop curative therapy for leukemia. To verify molecular mechanisms by which LSCs maintain a dormant state, we examined the activity of the major pro-survival signal pathways in LSCs (CD34+/CD38- compartment) and non-LSCs (CD34+/CD38+ compartment) counterparts from patients with acute myelogenous leukemia (AML, n=3) and acute lymphoblastic leukemia (ALL, n=1) by FACS. Interestingly, LSCs compartment expressed a greater amount of the phosphorylated forms of STAT5 (p-STAT5) than non-LSCs counterparts in all patients. Further studies found that levels of interleukin-1b (IL-1b) were significantly down-regulated in LSCs compared with non-LSCs (p<0.05) and normal hematopoietic stem cells (p<0.01), as measured by real-time RT-PCR. Importantly, exposure of LSCs to IL-1b (50 ng/ml) dephosphorylated STAT5 and decreased the population of cells in a dormant state, as assessed by cell cycle analysis. In addition, blockade of JAK2/STAT5 signaling by the specific JAK2 inhibitor AZ960 stimulated cell-cycling in LSCs in conjunction with down-regulation of cyclin-dependent kinase inhibitor p21waf1. As expected, IL-1b and AZ960 sensitized LSCs to cytarabine and the inhibitor of the FLT3 kinase, as assessed by clonogenic assay. Moreover, this study found that LSCs expressed a greater amount of anti-apoptotic protein Bcl-xL than non-LSCs counterparts. Exposure of LSCs to AZ960 potently induced apoptosis in parallel with down-regulation of Bcl-xL, as assessed by induction of the cleaved forms of PARP. Taken together, JAK2/STAT5 signaling may be a promising molecular target to eradicate LSCs in individuals with AML and ALL. Disclosures No relevant conflicts of interest to declare.
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Sharma, Neelam, and Anshul Jhanwar. "Study of incidence, trends and determinants of caesarean section in tertiary care hospital of Rajasthan, India." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 7, no. 7 (June 27, 2018): 2672. http://dx.doi.org/10.18203/2320-1770.ijrcog20182504.

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Background: Lower Segment Caesarean section (LSCS) is recommended when vaginal delivery might pose a risk to the mother or baby. Worldwide rise in LSCS rate during the last three decades, has been the cause of alarm and needs an in-depth study.Methods: It was a retrospective, observational study conducted in Obstetrics and Gynecology department of Jhalawar medical college, Jhalawar. Data were obtained from medical record database of patients admitted for deliveries from October 2017 to March 2018 over period of six months. The total number of patients delivered and the number of LSCS done were counted to find the incidence of LSCS in our hospital. Age, parity and gestational age of the patients who underwent LSCS were tabulated.Results: In present study the incidence of LSCS was 31.1%. Of these cases 91% belonged to age group 20 -29 yrs. Emergency LSCS (72.1%) and primary LSCS (66.5%) were more common. The commonest indication of LSCS was previous LSCS in 35% followed by foetal distress, breech presentation, severe oligohydrominos and pre-eclampsia.Conclusions: In present study LSCS rate was high as compared to the WHO standard. The scheme like Janani Suraksha Yojana (JSY) may have a great impact on accepting institutional deliveries by poor women which may be a reason of the increase of LSCS in India. Utilization of antenatal care, better doctor patient communication, doctor’s commitment to reduce the rate of LSCS, may help to reduce the increasing rate of caesarean delivery.
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Amrein, Michael A., Elias D. Bührer, Stefan Forster, Stephan Isringhausen, Christian M. Schürch, Salil S. Bhate, Mohamad Al Sayed, et al. "Splenic CD24low Red Pulp Macrophages Provide an Alternate Niche for Chronic Myeloid Leukemia Stem Cells." Blood 134, Supplement_1 (November 13, 2019): 1634. http://dx.doi.org/10.1182/blood-2019-126593.

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Chronic myeloid leukemia (CML) is a typical stem-cell driven malignancy, driven by leukemia stem cells (LSCs). LSCs are resistant to conventional therapies. This resistance is mediated by cell-intrinsic mechanisms and interactions with the microenvironment. LSCs depend on signals from a specialized microenvironment, a so called niche, to maintain their stem cell characteristics. In CML the bone marrow (BM) as a niche is well-investigated and several therapeutic targets, which aim at LSCs by interrupting their interaction with the BM-niche are under investigation. However, even though splenomegaly is a hallmark of CML the contribution of the splenic microenvironment to CML development has not been studied so far. This project aims to investigate the role of the splenic microenvironment as an independent secondary LSC niche and its contribution to disease development. To induce a CML-like disease in mice we retrovirally transduced FACS-sorted Lineage- Sca-1+ cKit+ BM cells with pMSCV-p210BCR/ABL-IRES-GFP and injected the transduced cells into non-irradiated mice. To find out if the spleen contributes to disease development we induced CML in splenectomized and sham operated mice. Splenectomized mice survived significantly longer compared to sham operated controls (median survival 31 vs. 22 days; p=0.0006) with 20% of the splenectomized mice surviving longer than 90 days. Moreover, the number of LSCs in the BM of splenectomized mice was reduced 3.7-fold (p=0.002). Flowcytometric analysis of the spleen and BM compartments of CML bearing mice revealed that the majority of the leukemic stem and progenitor cells (LSPCs) were located in the spleen (19-fold more LSCs in the spleen; p =0.007). Moreover we found the leukemic compartment in the spleen to be enriched for LSPCs compared to the BM (20 % spleen vs. 10 % BM; % LSPCs of total leukemic cells; p=0.01). To confirm this phenotypic observation functionally we performed a limiting dilution transplantation of leukemic cells from spleen and BM. In line with the phenotypic observation we found a higher frequency of LSCs in the spleen compared to the BM (1/41'703 vs. 1/432'594; p=0.02). We next analyzed the gene expression of LSPCs from spleen and BM. We found that the gene expression profile of splenic LSPCs showed higher expression of stemness-related genes and reduced expression of myeloid differentiation genes compared to BM LSPCs, indicating that the spleen is more supportive of primitive LSPCs. Knowing that the spleen contributes to disease development by providing an alternate niche for LSCs we next analyzed the spleens using confocal microscopy. We found that the LSCs resided exclusively in the red pulp. Previous studies have shown that HSCs reside in direct contact with red pulp macrophages (RPMs) during extramedullary hematopoiesis (Dutta et al., JEM, 2015). In addition we found that in spleens from human CML patients CD34+ leukemia cells localized together with macrophages (p=0.001). Furthermore we could show that RPMs are capable of producing both SCF and G-CSF. To test the role of RPMs as a potential niche component in vitro we co-incubated LSCs and RPMs overnight before plating the LSCs in a colony formation assay. We found that the co-incubation with RPMs improved the colony formation capacity of LSCs (CFUs 166 vs. 138; p=0.0356). To test the role of RPMs in vivo we depleted macrophages in CML mice using clodronate liposomes. This resulted in significantly reduced splenomegaly (867mg vs. 249mg; p<0.0001) and reduced numbers of splenic LSCs (23-fold; p=0.001). This was further confirmed in a genetically engineered mouse model lacking RPMs (Spic-/-) (735mg vs. 450mg; p=0.0112 and 22-fold fewer LSCs; p<0.0001). Finally, while in naïve mice RPMs can be differentiated into a CD24low and CD24high population, the CD24high population is lost in CML bearing mice. In summary, we found that the spleen provides an alternate niche for LSCs, thereby contributing to CML development. Compared to the BM niche the splenic niche is more supportive of primitive LSPCs, as shown by the higher frequency of LSCSs found in the spleen and the higher expression of stemness related genes in splenic LSCs compared to BM LSCs. Moreover we identified CD24low RPMs as a unique and central component of the splenic LSC niche. Even though we could show that RPMs are capable of producing SCF and G-CSF the exact mechanisms by which RPMs support LSCs remains to be investigated. Disclosures No relevant conflicts of interest to declare.
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Satake, Noriko, Connie Duong, Sakiko Yoshida, Ryan Davis, Stephenie Liu, Jonathan Van Dyke, Bridget McLaughlin, Jan A. Nolta, Nitin Nitin, and Cliff Tepper. "Leukemia Stem Cells in Acute Lymphoblastic Leukemia: Unveiling Hierarchical Structure at Single Cell Resolution." Blood 124, no. 21 (December 6, 2014): 4786. http://dx.doi.org/10.1182/blood.v124.21.4786.4786.

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Abstract Leukemia stem cells (LSCs) are the root of leukemia, and are responsible for drug resistance and disease relapse. However, LSCs have not yet been identified for acute lymphoblastic leukemia (ALL). Among many challenges, lack of phenotypic markers is one of the major problems in identifying ALL LSCs. In this study, we demonstrated a novel method to isolate LSCs from both T- and B- cell ALLs and further characterized their transcriptome profile at the single cell level. We have recently identified a novel method to isolate ALL LSCs based on cellular metabolic activities. We demonstrated that these isolated LSCs had in vivo leukemia-initiating capability (LIC). We have developed a series of primary ALL xenograft mouse models using patient samples and NOD/SCID/IL2Rg-/- (NSG) mice. Leukemia cells harvested from several generations of these mice were used in this study. We isolated LSCs and non-LSCs from 4 different B-cell type ALL samples and transplanted them separately into healthy NSG mice. Cell numbers used varied between 5, 10, and 50,000 per mouse, and the number of the animals varied between three and eight per group. All the animals transplanted with LSCs developed leukemia between 5-14 weeks, whereas those transplanted with non-LSCs did not develop the disease within the same timeframe or by the end of the study, which was more than 4 months after leukemia development in the LSC group. In order to characterize and identify potential therapeutic targets in the LSCs, we investigated the transcriptome profile of these cells. First, we performed genomewide microarray gene expression profiling of RNA isolated from the LSCs and non-LSCs using 4 ALL cell lines (Reh, JM1, Jurkat, and Molt4). There were 173 genes which showed at least 2-fold difference in gene expression between the LSCs and non-LSCs. Using a panel of primer sets for the 100 genes exhibiting the highest difference in expression, we performed qRT-PCR for these genes in the isolated LSCs and non-LSCs from 11 primary ALL samples (10 B-cell and 1 T-cell type) transplanted and harvested from our NSG xenograft mouse models at different generations. There was a distinct difference in the transcriptome profile between the LSCs and non-LSCs in these primary ALL samples. Overall gene expression of 93 LSC signature genes was much lower in the LSCs than in the non-LSCs. Recent advances in microfluidic technologies allowed us to investigate cells at single cell resolution. Growing evidence suggests that cancer stem cells consist of heterogeneous cell populations (subclones). Therefore, we further investigated whether these isolated LSCs have subclones using the Fluidigm C1 and Biomark system. Preliminary results using a primary ALL sample harvested from our xenograft mouse model, indicate that there are at least two distinct subclones in the LSCs based on principal component analysis of the single cell data. In summary, we 1) developed a novel method to isolate ALL LSCs which have in vivo LIC, 2) demonstrated that isolated LSCs have a distinct transcriptome profile, and 3) discovered that the LSCs seem to consist of subclones. Currently we are in the process of performing detailed comprehensive transcriptome analyses and additional single cell transcriptome assays. Disclosures No relevant conflicts of interest to declare.
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Buss, Ray R., and James G. Allen. "Leader Scholar Communities: Supporting EdD Students’ Dissertation in Practice Efforts." Impacting Education: Journal on Transforming Professional Practice 5, no. 3 (October 6, 2020): 1–7. http://dx.doi.org/10.5195/ie.2020.98.

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In this essay, we discuss Leader Scholar Communities (LSCs), which have proven to be helpful in supporting students’ dissertation in practice (DiP) efforts in several CPED-guided programs. We have organized this essay around four important topics including (a) describing a theoretical framework that serves as the foundation for LSCs, (b) providing a rationale for using LSCs, (c) illustrating how LSCs have been implemented to support students’ DiP efforts in our EdD programs, and (d) exploring the benefits and limitations of LSCs. We have also presented research information about graduates’ perceptions of LSCs. We concluded by presenting some questions others might wish to contemplate as they consider the use of LSCs to support their students’ DiP efforts.
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Zhang, Haojian, Huawei Li, and Shaoguang Li. "HIF1α Is Required for Survival Maintenance of Chronic Myeloid Leukemia Stem Cells." Blood 118, no. 21 (November 18, 2011): 449. http://dx.doi.org/10.1182/blood.v118.21.449.449.

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Abstract Abstract 449 Chronic myeloid leukemia (CML) is a clonal hematopoietic stem cell disorder induced by the BCR-ABL oncogene, and available BCR-ABL kinase inhibitors fail to completely eradicate leukemia stem cells (LSCs) to cure the disease. The challenge lies in the identification of genes that play a critical role in survival regulation of LSCs. Hypoxia-inducible factor-1α (HIF1α), a master transcriptional regulator of the cellular and systemic hypoxia response, is essential for the maintenance of self-renewal capacity of normal hematopoietic stem cells (HSCs). It is still unknown about the role of HIF1α in survival regulation of LSCs in CML. Using a mouse model of CML, here we report that HIF1α plays a crucial role in survival maintenance of LSCs. We conducted a DNA microarray analysis to compare the gene expression profiles between LSCs and normal HSCs in our bone marrow transplantation (BMT) mouse model of CML. We retrovirally transduced bone marrow cells from C57BL/6J (B6) mice with BCR-ABL-GFP or GFP alone (as a normal HSC control) and transplanted the transduced cells into lethally irradiate B6 recipient mice to induce CML. Two weeks after BMT, we sorted GFP+LSK (Lin−Sca-1+c-Kit+) cells from bone marrow of the mice for the Affymetrix microarray analysis. HIF1α gene was up-regulated by BCR-ABL in LSCs. We next examined expression of genes known to be specifically regulated by HIF1α, and found that expression of VEGF, GLUT1 and TGFa, except for PGK1, were significantly higher in LSCs than in HSCs. Real time RT-PCR assay confirmed the up-regulation of HIF1a and other hypoxia-responsive genes by BCR-ABL in LSCs. To determine the role of HIF1α in BCR-ABL leukemiogenesis, we crossed mice carrying a loxP-flanked HIF1a allele with Cre transgenic mice in which expression of Cre is driven by the Vav regulatory element to induce the deletion of the HIF1a gene mainly in the hematopoietic system. We transduced bone marrow cells from 5-FU-treated wild type (WT) or HIF1a−/− mice with BCR-ABL-GFP retrovirus, and then transplanted into lethally irradiated recipient mice to induce primary CML, followed by a secondary transplantation. We found that HIF1α−/− LSCs failed to induce CML in the secondary recipient mice, whereas WT LSCs efficiently induced CML. The defective CML phenotype in the absence of HIF1α was consistent with a gradual decrease of the percentages and total numbers of leukemia cells in peripheral blood and with much less severe splenomegaly. These results indicate that HIF1α is required for CML development, and suggest that HIF1α is required for survival maintenance of LSCs. To understand the underlying mechanisms, we analyzed the effect of HIF1α on cell cycle progression and apoptosis of LSCs, and found that the percentage of HIF1α−/− LSCs in the S-G2/M phase was significantly lower than that of WT LSCs, indicating that the HIF1α deficiency causes a cell cycle arrest of LSCs. Furthermore, we examined whether deletion of HIF1α induces apoptosis of LSCs by staining the cells with annexin V and 7AAD, and found that HIF1α−/− LSCs had a higher apoptotic rate than WT LSCs. We further compared expression levels of three cyclin-dependent kinase inhibitors p16Ink4a, p19Arf, and p57 between HIF1α−/− and WT LSCs, and found that the cell cycle arrest caused by the HIF1α deficiency was associated with significantly higher levels of expression of p16Ink4a, p19Arf and p57 in HIF1α−/− LSCs than in WT LSCs. In addition, we observed an increased expression of the apoptotic gene p53 in HIF1α−/− LSCs, explaining the increased apoptosis of HIF1α−/− LSCs. In summary, our results demonstrate that HIF1α represents a critical pathway in LSCs and inhibition of the HIF1α pathway provides a therapeutic strategy for eradicating LSCs in CML. Disclosures: No relevant conflicts of interest to declare.
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Zhang, Haojian, Huawei Li, Hualin S. Xi, and Shaoguang Li. "HIF1α is required for survival maintenance of chronic myeloid leukemia stem cells." Blood 119, no. 11 (March 15, 2012): 2595–607. http://dx.doi.org/10.1182/blood-2011-10-387381.

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Abstract Hypoxia-inducible factor-1α (HIF1α), a master transcriptional regulator of the cellular and systemic hypoxia response, is essential for the maintenance of self-renewal capacity of normal HSCs. It is still unknown whether HIF1α has a role in survival regulation of leukemia stem cells (LSCs) in chronic myeloid leukemia (CML). Using a mouse model of CML, here we report that HIF1α plays a crucial role in survival maintenance of LSCs. Deletion of HIF1α impairs the propagation of CML through impairing cell-cycle progression and inducing apoptosis of LSCs. Deletion of HIF1α results in elevated expression of p16Ink4a and p19Arf in LSCs, and knockdown of p16Ink4a and p19Arf rescues the defective colony-forming ability of HIF1α−/− LSCs. Compared with normal HSCs, LSCs appear to be more dependent on the HIF1α pathway. Together, these results demonstrate that HIF1α represents a critical pathway in LSCs and inhibition of the HIF1α pathway provides a therapeutic strategy for eradicating LSCs in CML.
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Gezer, Deniz, Amelie V. Guitart, Milica Vukovic, Chithra Subramani, Karen Dunn, Patrick Pollard, Peter J. Ratcliffe, Tessa L. Holyoake, and Kamil Kranc. "HIF-1α Is Not Essential For The Establishment Of MLL-Leukaemic Stem Cells." Blood 122, no. 21 (November 15, 2013): 3767. http://dx.doi.org/10.1182/blood.v122.21.3767.3767.

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Abstract Haematopoietic stem cells (HSCs) reside in hypoxic niches in the bone marrow (BM) and sustain long-life haematopoiesis. HSCs are largely quiescent, self-renew, undergo apoptosis and generate progenitor cells, which differentiate to multiple blood lineages. The strict regulation of the balance between these fate decisions is essential for haematopoiesis and their dysregulation in HSCs and progenitor cells can result in leukaemic transformation. HSCs and leukemic stem cells (LSCs) are suggested to share the same niche and are in need to adapt to hypoxic conditions. Hypoxia-inducible-factor-1α (HIF-1α) is a key mediator of cellular responses to hypoxia and is important for the maintenance of HSC functions under stressful conditions. Furthermore, in chronic myeloid leukaemia (CML) and acute myeloid leukaemia (AML) HIF-1α is essential for LSC maintenance and ablation or knockdown of HIF-1α leads to exhaustion of established LSCs. The aim of this study was to investigate the requirement for HIF-1α in the generation of pre-LSCs and the establishment of LSCs. To investigate the role of HIF-1α in the generation of pre-LSCs we retrovirally transduced haematopoietic stem and progenitor cells (HSPCs) from either WT or HIF1-αfl/fl Vav-iCre with MLL-ENL retroviruses. Next we performed serial re-plating assays under normoxic and hypoxic conditions to generate pre-LSCs. Surprisingly, WT and HIF-1α deficient HSPCs generated comparable numbers of colonies in normoxia and hypoxia (Fig. 1a). In addition no significant difference was found in the immunophenotypic profile of colonies (Figure 1b). Furthermore, microscopic examination indicated that colonies of all genotypes were dense consistent with their transformed shape (Fig. 1c). WT and HIF-1α-deficient pre-LSCs cultured under normoxia and hypoxia had similar cloning efficiency, which is known to directly correlate with the numbers of LSCs in vivo (Fig. 2). These results indicate that HIF-1α is dispensable for the generation of pre-LSCs. To test the role of HIF-1α in establishment of LSCs from pre-LSCs we transplanted pre-LSCs into lethally irradiated mice together with support BM and monitored the mice for disease development. No significant difference was found in disease latency (Fig. 3a) or frequency of LSCs in peripheral blood, bone marrow or spleens (Fig. 3b) indicating that pre-LSCs lacking HIF-1α can efficiently generate LSCs that cause aggressive AML. In conclusion, we provide genetic evidence that HIF-1α is dispensable for the generation of pre-LSCs and the establishment of LSCs from pre-LSCs. These surprising findings, together with published results indicating that HIF-1α is essential for maintenance of LSCs, imply that HIF-1α has different roles at different stages of leukaemic transformation. Further studies are required to explain the distinct roles of HIF-1α in different stages of leukaemogenesis. Disclosures: Ratcliffe: RedOx: Founder Other. Holyoake:Novartis: Membership on an entity’s Board of Directors or advisory committees; Bristol Myers Squibb: Membership on an entity’s Board of Directors or advisory committees; Ariad: Membership on an entity’s Board of Directors or advisory committees.
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Khan, Mehak Asim, Irum Sohail, and Maria Habib. "Auditing the cesarean section rate by Robson’s ten group classification system at Tertiary Care Hospital." Professional Medical Journal 27, no. 04 (April 10, 2020): 700–706. http://dx.doi.org/10.29309/tpmj/2020.27.04.3383.

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Objectives: To analyze the trends of cesarean sections, categorize them into Robson’s Ten Group Classification System (RTGCS), to identify the groups contributing the most to overall lower segment cesarean section (LSCS) rate and to formulate strategies for reducing these rates. Study Design: Cross sectional population based study. Setting: Gynecology and Obstetrics Department of Kahuta Research Laboratories (KRL) hospital, Islamabad. Period: From 1st Nov, 2017 to 30th April, 2018. Material & Methods: The births during this period were distributed into the RTGCS on the basis of past obstetric history and fetal characteristics along with mode of onset of labour. Overall LSCS rate was calculated and contribution of each group was analyzed separately by SPSS version 23. Results: Our study showed 617 LSCS out of 964 deliveries making a high LSCS rate of 64%. Group 5, 2 and 10 of RTGCS contributed to the majority of LSCS performed with the percentages of 47.5%, 18.5% and 12.8% respectively. Group 5 of RTGCS which contributed to the highest LSCS rate had 354 subjects which were previous scars out of which 199 had previous 1 scar making the percentage 56.21%. It contributed 32.3% to the overall LSCS rate. Conclusion: RTGCS is a very useful tool for auditing the LSCS rate at local, national and international levels. Once the LSCS are classified into specific RTGCS, analysis can be done about the reasons for the increasing rates of LSCS and then strategies can be devised to reduce them.
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Dissertations / Theses on the topic "LSCs"

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Davis, Nathaniel J. L. K. "Applications of spectral management in optoelectronic devices." Thesis, University of Cambridge, 2017. https://www.repository.cam.ac.uk/handle/1810/263670.

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The application and efficiency of optoelectronic devices depends on the ability to control the absorption and emission processes of photons in semiconductors. This thesis looks at three different applications of spectral management across a broad range of optoelectronic devices: photovoltaics (PVs), luminescent solar concentrators (LSCs) and light-emitting diodes (LEDs). Multiple excitation generation (MEG) – a process in which multiple charge-carrier pairs are generated from a single optical excitation - is a promising way to improve the photocurrent in photovoltaic devices and offers the potential to break the Shockley-Queisser limit. Here we present solar cells fabricated from PbSe nanorods which show external quantum efficiencies exceeding 100 %. This demonstrates the potential for substantial improvements in PV device performance due to MEG. Through spatial and spectral concentration, LSCs have the potential to reduce the cost of photovoltaic energy production and are attractive prospects for photobioreactors and building-integrated applications. Here we introduce versatile star-shaped donor-acceptor molecules based on a central BODIPY acceptor with oligofluorene donor side units. We perform comprehensive device measurements and Monte Carlo ray tracing simulations of LSCs. We find that the measured structures permit waveguide propagation lengths on a par with state-of-the-art nanocrystalline emitters, while proposed hypothetical structures can be seen as viable candidates for photobioreactor and energy production roles and should be synthesized. The efficiency of nanocrystal-based LEDs is inherently limited by the types of crystals used. Cesium lead halide perovskite nanocrystals exhibit photoluminescence quantum efficiencies approaching 100%. However, due to the large surface areas and anion mobility halogen exchange between perovskite nanocrystals of different compositions occurs rapidly, limiting applications. Here, we report significantly reduced halide exchange between chloride and iodide CsPbX3 (X= Cl, I) perovskite nanocrystals. We investigate perovskite-based multi-crystal component samples and their resulting optical and electrical interactions in bulk heterojunction LEDs. Efficient photon reabsorption from CsPbCl3 to CsPbI3 nanocrystals was found to improve LED device performance.
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Siengchum, Tritti. "Electrochemical Oxidation of Methane on Ni-Doped Perovskite Anode Solid Oxide Fuel Cell." University of Akron / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=akron1248205545.

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Vaelske, Veit. "lsis im Osten." Doctoral thesis, Humboldt-Universität zu Berlin, 2018. http://dx.doi.org/10.18452/19155.

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Die im Oktober 2011 verteidigte und mit der Note "summa cum laude" bewertete Arbeit beschäftigt sich mit der Auswertung aller bis 2011 bekannt gewordener Zeugnisse, die im Nahen Osten auf eine Kenntnisnahme und Verehrung der ägyptischen Götter Isis, Sarapis, Apis, Harpokrates etc. hindeuten. Eine grundlegende Materialaufnahme mithilfe eines DAAD-Stipendiums erfolgte 2003 bis 2004 in allen Levanteländern. Die im Zuge dieser Recherchen allerdings ausufernde Materialbasis führte dazu, den Fokus der Dissertation auf die südliche Levante zu richten. Zeitlich wurden vor allem die Jahrhunderte der hellenistischen und römischen Beherrschung des Gebiets näher untersucht.
This thesis, defended in October 2011 and rated "summa cum laude", evaluates testimonies that became known until 2011, which in the Middle East point to a recognition and worship of the Egyptian gods Isis, Sarapis, Apis, Harpocrates, etc. , Basic material was collected with the help of a DAAD scholarship in 2003-2004 in all Levant countries. However, in the course of these researches, a sprawling material base led to the focus of the dissertation on the southern Levant. In particular, the centuries of Hellenistic and Roman domination of the area were examined more closely.
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Mirzababaei, Jelvehnaz. "LSCF Synthesis and Syngas Reactivity over LSCF-modified Ni/YSZ Anode." University of Akron / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=akron1312225644.

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Karlberg, Marlene, and Katarina Pettersson. "Barnperspektivet i LSS : en kvalitativ studie om LSS-handläggares uppfattning." Thesis, Högskolan i Gävle, Avdelningen för socialt arbete och psykologi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:hig:diva-11351.

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Syftet med uppsatsen var att belysa hur LSS-handläggare tolkade begreppet barnperspektiv och hur detta applicerades i utredningsarbetet. Vi har genomfört kvalitativa intervjuer med sex LSS-handläggare och resultaten analyserades med hjälp av teorin om sociala konstruktioner. I analysen av intervjuerna identifierades fem centrala teman som vi såg som förklarande faktorer angående hur LSS-handläggarna applicerade barnperspektivet i handläggningen. Dessa teman var utredningsförfarandet, avsaknaden av riktlinjer och utredningsmetod, barnperspektivet kontra barns perspektiv, delaktighet och inflytande samt kommunikation. Det framkom att avsaknaden av riktlinjer och utredningsmetoder medförde att LSS-handläggarna själva fick konstruera egna sätt för hur barnperspektivet skulle appliceras. Samtliga LSS-handläggare kunde definiera hur de själva uppfattade barnperspektivet men däremot hade de svårigheter att veta hur detta rent praktiskt skulle tillämpas. Analysresultatet visade att det mestadels var den vuxnes syn på barnperspektivet som var rådande och inte barnets egen syn på sin tillvaro. Kommunikationssårigheter var en bidragande orsak till bristen på delaktighet och inflytande hos barn med funktionsnedsättningar.
The purpose of this study was to elucidate how LSS administrators interpreted the concept of child perspective and how this was applied in the investigation. We conducted qualitative interviews with six LSS administrators and the results were analyzed using the theory of social constructions. The analysis of the interviews identified five key themes that we saw as explanatory factors regarding how LSS administrators applied the child perspective in the investigations. These themes were investigative procedure, the lack of guidance and investigation method, the child perspective versus the child´s own point of view, participation and influence, and communication. It was found that the lack of guidelines and methods of investigation led to the LSS administrators themselves had to construct their own way of how the child perspective should be applied. All LSS administrators could define how they perceived the child´s perspective but they had difficulty in knowing how this should be applied in practice. The analytical results showed that it was mostly the adult´s views on the child´s perspective that was present and not the child´s own view of his existence. Communication difficulties were a contributing factor to the lack of involvement and influence of children with disabilities.
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Ståhl, Linett. "LSS - ”Luddig, suddig och svår” En kvalitativstudie om LSS handläggare." Thesis, Halmstad University, School of Social and Health Sciences (HOS), 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-2325.

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En individ med funktionsnedsättning ställs varje dag inför en rad olika svårigheter i vårt samhälle och de är ständigt i behov av att samhället finns till hjälps för dem. Varje individ är olika och behöver därför olika hjälp för att klara sin vardag.

Sedan 1994 finns lagstiftningen Lagen om stöd och service till vissa funktionshindrade. Denna lag ska se till så att individer med vissa funktionsnedsättningar får rätt insatser så att de kan ha goda levnadsvillkor. De personer som ansvara för denna lag är LSS handläggare. Deras arbete är mycket betydelsefullt för individerna som är i behov av denna lag. Deras arbete består av en rad olika uppdrag, de ska följa lagens smala ramar samt individens behov men också följa kommunens tillgångar. Denna lag är en rättighetslag som innebär att individen har rätt till vissa insatser. I denna uppsats tittar jag närmar på hur en LSS handläggares arbetssituation ser ut, vilka problem och bekymmer kan de stötta på samt vad de egentligen anser om lagen. Jag har valt att använda en kvalitativ forskningsmetod. Detta för jag vill få en förståelse för hur LSS handläggare upplever sin arbetssituation och se erfarenheterna som den enskilda personen bär med sig. Jag har intervjuat sju LSS handläggare från fem olika kommuner.

För att förstå handläggarnas situation har jag tagit hjälp av tre olika sociologer, Ralph Lintons Rollteori, Max Webers teori om byråkrati samt idealtyper, C Wright Mills tolkning av koncepten problem och bekymmer.

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Andersson, Christina. "Kontaktperson enligt LSS : En studie av normförekomst i rättstillämpningen av LSS." Thesis, Linnéuniversitetet, Institutionen för socialt arbete, SA, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-21701.

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The aim of this study was to examine the occurence of norms in court cases regarding the Swedish law of support and service for disabled (Lag 1993:387 om stöd och service till vissa funktionshindrade) with the help of a discourse analysis method. More specifically its aim was to examine and identify norms in the different dictums/statements that were to be found in the court cases regarding the supportive institution "contact person" according to the Swedish law "LSS" with the help of a norm science approach. The aim was also to examine when the applicant was found to be entitled to a contact person according to the LSS-law. To be able to do this, the author studied thirty-four different court cases. In these cases six themes were found, that indicated the occurence of norms. The conclusion was that there were indeed norms occurring in the court cases, due to a normative legislation and therefore the interpretations of the legislation also become normative, but also due to the fact that judges and social workers incorporate their own internalized societal norms in their judgements.
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Piuva, Ninni, and Anja Henricsson. "Barnkonventionens verkan inom LSS-handläggning." Thesis, Malmö universitet, Fakulteten för hälsa och samhälle (HS), 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-26548.

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Syftet med denna studie är att undersöka hur barnperspektivet beaktas vid handläggning inom LSS, samt att undersöka hur barnets rättigheter, enligt Barnkonventionen, beaktas under processen. Eftersom Barnkonventionen blir lag 2020 ville vi få insikt i hur Barnkonventionen används praktiskt inom LSS. I studien har vi två frågeställningar för att besvara vårt syfte, Vad innebär det att ha ett barnperspektiv i praktiken inom LSS-handläggning? och Hur tillämpas Barnkonventionen i ärenden som berör barn? För att besvara frågeställningarna använde vi oss av en kvalitativ metod med semistrukturerade intervjuer, där vi intervjuade åtta biståndshandläggare som arbetar inom LSS. För att analysera materialet från intervjuerna använde vi kodning och tematisering. Följande teman hittades; miljö, kommunikation och delaktighet, dokumentation, föräldrar till barn med funktionsnedsättning, barn som anhöriga och kunskapsbrist och utbildning. Det empiriska materialet analyserades med hjälp av vårt kunskapsläge och våra utvalda teorier barndomssociologi, Foucaults maktteori och KASAM. Resultatet av vår studie har visat att det saknas kunskap och resurser när det gäller barn med funktionsnedsättning. Biståndshandläggarna vet inte hur olika kommunikationshjälpmedel och Barnkonventionen används i praktiken, vilket resulterar i att barn med funktionsnedsättning berövas sina rättigheter. Vi kan se mycket engagemang och vilja hos biståndshandläggarna eftersom de vill förbättra denna situation, men mer ansträngning krävs för att utveckla metoder som kan främja rättssäkerhet för barn med funktionsnedsättningar.
The purpose of this study is to examine how the child's perspective is taken into account when dealing with LSS, and to understand if the child's rights, according to the Children's rights convention, is taken into account during the process. As the Children’s rights convention becomes a law in 2020 we wanted to gain insight into how the children's rights convention is used practically within LSS. In the study we have two questions to answer about our purpose, What does it mean to have a child perspective in practice within LSS handling? and How is the Children's rights convention applied in cases involving children? To answer the questions, we have chosen to use a qualitative method with semi-structured interviews, where we interviewed eight care managers working with LSS. In order to analyze the material, obtained from the interviews, we used coding and thematization. The following themes were found; environment, communication and participation, documentation, parents of children with disabilities, children as a relative and lack of knowledge and education. The empirical material was analyzed with the help of our state of knowledge and our selected theories childhood sociology, Foucault’s power theory and KASAM. The result of our study has shown that there is a lack of knowledge and resources, regarding children with disabilities. The care managers doesn’t know how different communication aids and the Children’s rights convention, is being used in practice, which result in children with disabilities being deprived of their rights. We can see a great deal of commitment and a willingness in the care managers because they want to improve this situation, but more effort is needed to develop methods that can promote legal security for children with disabilities.
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Sjöström, Jens, and Martin Wendestam. "Inflytande och självbestämmande inom LSS." Thesis, Malmö högskola, Fakulteten för hälsa och samhälle (HS), 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-24567.

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Syftet med denna studie är att belysa hur personal inom LSS upplever brukares möjlighet till inflytande och självbestämmande avseende sina måltidssituationer. Syftet är uppdelat i två frågeställningar, för det första hur personal upplever brukares möjlighet till inflytande och självbestämmande rörande måltider. För det andra, vilket organisatoriskt handlingsutrymme personalen har rörande brukares måltidssituationer. Det empiriska materialet består av sex intervjuer med sex informanter, som alla arbetar i två olika kommuner i Sverige. Resultatet visar att det har hänt mycket för brukarna i positiv riktning rörande självbestämmande, framförallt sedan avinstitutionaliseringen på 1980-talet. Samtliga informanter upplever att brukare idag har stort inflytande och stort självbestämmande över det som rör deras måltider. Avseende handlingsutrymme upplever informanterna att det finns ett organisatoriskt ramverk att följa, samtidigt som det finns utrymme för att gå in mer självständigt i arbetet och fatta egna beslut. Personalen skapar sig handlingsutrymme om organisationens styrsystem inte är tillräckligt anpassade för verksamheten. Vi kan konstatera att resultaten i denna studie till stor del samstämmer med tidigare gjord forskning, men att studien samtidigt innehåller nya element inför framtida forskning.Nyckelord: delaktighet, funktionsnedsättning, inflytande, LSS, måltider, självbestämmande.
The purpose of this study is to illustrate how social workers within the Swedish act concerning support and service for persons with certain functional impairments experience these persons ability for self-determination and influence regarding meal situations. The purpose is broken down into two main questions, firstly how social workers experience the functional impaired possibilities for influence in meal situations. Secondly, what kind of discretion does the social worker have within the organisation, regarding these clients’ meal situations. The empirical material consists of six interviews with six social workers, working in two different communities in Sweden. The result shows that a lot has happened in positive direction concerning the functional impaired possibilities for self-determination, especially since the deinstitutionalization in the 1980’s. All informants perceive that functional impaired today have great influence and great autonomy related to their meals. The informants experience that there is an organizational framework to follow, while there is room to be independent at work and to make their own decisions. The staff creates the discretion if the organization's management system is not sufficiently tailored to the business. We can conclude that the results of this study mostly is in alignment with previous research done, but the study also includes new elements for future research.Keywords: autonomy, disability, discretion, influence, LSS, meals, participation, self-determination.
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Sedin, Marcus. "VVS-projekteringsförslag på LSS-bostad." Thesis, Umeå universitet, Institutionen för tillämpad fysik och elektronik, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-121943.

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I Sverige finns det cirka 4,5 miljoner bostäder och den siffran stiger i lika snabb takt med den ökande befolkningen. Riksdagen har beslutat att energianvändningen ska minska i två etapper utifrån EU:s direktiv att uppnå så kallade näranollenergibyggnader.Här beskrivs vilka parametrar som utgör en byggnads energiprestanda och hur man sänker energianvändningen i bostäder genom VVS-projektering. Framförallt hur man kan nå detta utifrån den ekonomiska aspekten. Vilka regler och krav måste följas för att inte påverka människans hälsa.Projektet innefattar teoretiska sammanställningar av VVS komponenter som är grunden till genomförandet. Den tänkta bostaden byggdes upp och simulerades i simuleringsprogrammet IDA ICE för att plocka fram viktig information till VVS-projekteringen.Resultatet visar att en bergvärmepump är en fördelaktig värmekälla ekonomiskt men framförallt energimässigt. Ventilationssystemet klarade att upprätthålla ett gott inomhusklimat utan att bryta mot några föreskrifter.
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Books on the topic "LSCs"

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Cook, M. Shelf life extension for the lot AAE nozzle severance LSCs: Final test report. Brigham City, UT: Thiokol Corp., Space Operations, 1990.

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Panasonic. Microcomputers and peripheral LSIs. Kyoto: Matsushita Electronics Corp, 1989.

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Saunders, Christopher Thomas. Reflections on the LSMS group meeting. Washington, D.C., U.S.A: World Bank, 1985.

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Grunewald, Karl. Handikapplagen LSS: Och annan närliggand lagstitning. 5th ed. Stockholm: Norstedts juridik, 2005.

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Library, Illinois State. LSCA great ideas: Library innovations in Illinois, 1986-1987. Springfield, Ill.]: Jim Edgar, Secretary of State and State Librarian, 1987.

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Library, Montana State. Montana 1993 LSCA Titles I & III grant application guidelines. [Helena]: Montana State Library, 1992.

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sąjunga, Lietuvos Studentų atstovybių. LSAS: Lietuvos aukštųjų mokyklų studentų ir absolventų sociologinis tyrimas. Vilnius: Lietuvos Studentų atstovybių sąjunga, 2004.

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Parsons, David J. Qualifications of staff in LSC-funded provision. Nottingham: DfES, 2004.

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Ainsworth, Martha. Guidelines for adapting the LSMS living standards questionnaires to local conditions. Washington, D.C., U.S.A: World Bank, 1988.

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Socialdepartementet, Sweden. Utjämning av kostnadsskillnader för verksamhet enligt LSS: En fältstudie. Stockholm]: Regeringskansliet, Socialdepartementet, 1997.

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Book chapters on the topic "LSCs"

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Harel, David, and Rami Marelly. "The Language: Live Sequence Charts (LSCs)." In Come, Let’s Play, 59–82. Berlin, Heidelberg: Springer Berlin Heidelberg, 2003. http://dx.doi.org/10.1007/978-3-642-19029-2_5.

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Guo, Hai-Feng, and Mahadevan Subramaniam. "Symbolic Production Grammars in LSCs Testing." In Computer and Information Science 2012, 105–20. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-30454-5_8.

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Patzina, Sven, Lars Patzina, and Andy Schürr. "Extending LSCs for Behavioral Signature Modeling." In IFIP Advances in Information and Communication Technology, 293–304. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-21424-0_24.

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Maoz, Shahar, Jani Metsä, and Mika Katara. "Model-Based Testing Using LSCs and S2A." In Model Driven Engineering Languages and Systems, 301–6. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-642-04425-0_22.

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Brill, Matthias, Ralf Buschermöhle, Werner Damm, Jochen Klose, Bernd Westphal, and Hartmut Wittke. "Formal Verification of LSCs in the Development Process." In Integration of Software Specification Techniques for Applications in Engineering, 494–516. Berlin, Heidelberg: Springer Berlin Heidelberg, 2004. http://dx.doi.org/10.1007/978-3-540-27863-4_27.

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Kotdawala, Parul J., and Munjal J. Pandya. "Difficulty in the Delivery of a Baby During LSCS." In Principles of Critical Care in Obstetrics, 355–68. New Delhi: Springer India, 2016. http://dx.doi.org/10.1007/978-81-322-2692-5_34.

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Harel, David, Hillel Kugler, and Gera Weiss. "Some Methodological Observations Resulting from Experience Using LSCs and the Play-In/Play-Out Approach." In Scenarios: Models, Transformations and Tools, 26–42. Berlin, Heidelberg: Springer Berlin Heidelberg, 2005. http://dx.doi.org/10.1007/11495628_2.

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"LSCs." In Encyclopedia of Cancer, 2543. Berlin, Heidelberg: Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-46875-3_101380.

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Singh, Tania. "Previous LSCS." In Ward Rounds in Obstetrics and Neonatology, 83. Jaypee Brothers Medical Publishers (P) Ltd., 2016. http://dx.doi.org/10.5005/jp/books/12789_28.

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Edwards, Alison. "Caesarean section (LSCS)." In Labour Midwifery Skills, 11–12. Routledge, 2020. http://dx.doi.org/10.4324/9780429424298-5.

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Conference papers on the topic "LSCs"

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Wang, Qiange, Yiming Ma, Libing Zhou, and Jin Wang. "Electrical Characteristics Analysis of LSCs Under Composite Fault." In 2021 IEEE International Electric Machines & Drives Conference (IEMDC). IEEE, 2021. http://dx.doi.org/10.1109/iemdc47953.2021.9449563.

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Almashqbeh, S. F. "Biomechanics of Regular and Lateral Stair Climbing." In ASME 2012 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/imece2012-85503.

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The kinematic and kinetic differences between two styles of stair climbing, namely regular stair climbing (RSC) and lateral stair climbing (LSC), was studied. A four-step wooden stair instrumented with two force plates was used as the action platform. The kinematic and kinetic recordings were collected using a 6-camera, 2-force plate commercial three-dimensional motion analysis system. The LSC activity was subdivided into LSCL activity, where the right leg was the leading leg, and LSCT.
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Ying, Shang-Ping, Bing-Mau Chen, and An-Ting Li. "The characteristics of luminescent solar concentrators (LSCs) using inorganic phosphors." In Nonimaging Optics: Efficient Design for Illumination and Solar Concentration XIV, edited by Sarah R. Kurtz and Roland Winston. SPIE, 2017. http://dx.doi.org/10.1117/12.2272907.

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Sindhu and C. S. Sanikop. "Anaesthetic Management of Pregnant Woman with Coarctation of Aorta for LSCS." In ISACON KARNATAKA 2017 33rd Annual Conference of Indian Society of Anaesthesiologists (ISA), Karnataka State Chapter. Indian Society of Anaesthesiologists (ISA), 2017. http://dx.doi.org/10.18311/isacon-karnataka/2017/ep051.

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Rupinder Singh, M. "ESRA19-0075 Effect of prophylactic intravenous ondansetron on maternal hemodynamics during elective lscs." In Abstracts of the European Society of Regional Anesthesia, September 11–14, 2019. BMJ Publishing Group Ltd, 2019. http://dx.doi.org/10.1136/rapm-2019-esraabs2019.149.

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Eggink, Wouter, and Angele Reinders. "Design it with LSCs; an exploration of applications for Luminescent Solar Concentrator PV technologies." In 2017 IEEE 44th Photovoltaic Specialists Conference (PVSC). IEEE, 2017. http://dx.doi.org/10.1109/pvsc.2017.8366790.

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Horita, Teruhisa. "Coating of SOFC Metallic Interconnects and Their Oxygen Diffusivity." In ASME 2010 8th International Conference on Fuel Cell Science, Engineering and Technology. ASMEDC, 2010. http://dx.doi.org/10.1115/fuelcell2010-33254.

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La0.8Sr0.2Co0.2Fe0.8O3 (LSCF) coating on Fe-Cr alloy was examined for use as interconnects in SOFC. Thermal cyclic oxidation was conducted on the LSCF coated Fe-Cr alloy to evaluate the interface evolution at LSCF/oxide scale/Fe-Cr alloy. The thickness of oxide scales increased at the LSCF coating/Fe-Cr alloy interfaces with increasing the number of thermal cycles. SIMS depth profiles were obtained after thermal cycling for the LSCF/alloy interfaces region: the oxide scale consisted of (Fe)-Mn-Cr spinel, Cr2O3, and SiO2. Elemental distribution of oxide scales is very similar to the non-coated Fe-Cr alloy. A relatively high diffusivity of oxygen (oxide ions) was observed within the LSCF coating. However, the diffusion of oxygen was blocked by the oxide scales, especially at the Cr2O3 region. The oxide scale growth rates were effectively reduced by the LSCF coating on the Fe-Cr alloy. The effects of the LSCF coating on the oxide scale growth are discussed.
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Goncharov, A. A., and O. Yu Inkova. "IMPLICIT LOGICAL-SEMANTIC RELATIONS AND A METHOD OF THEIR IDENTIFICATION IN PARALLEL TEXTS." In International Conference on Computational Linguistics and Intellectual Technologies "Dialogue". Russian State University for the Humanities, 2020. http://dx.doi.org/10.28995/2075-7182-2020-19-310-320.

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One of the main characteristics of logical-semantic relations (LSRs) between two fragments of a text is that these relations can be either explicit (expressed by some marker, e.g. a connective) or implicit (derived from the interrelation of these fragments’ semantics). Since implicit LSRs do not have any marker, it is difficult to find them in a text (whether automatically or not). In this paper, approaches to analysing implicit LSRs are compared, an original definition for them is offered and differences between implicit LSRs and LSRs expressed by non-prototypical means are described. A method is proposed to identify implicit LSRs using a parallel corpus and a supracorpora database of connectives. Based on the well-known statement that LSRs can be explicitated by adding connectives in the translation, it is argued here that through selecting pairs in which fragments where a connective is used to express an LSR in the translation correspond to those containing any of the translation stimuli standard for this connective in the source language, it is possible to get an array of contexts in which this LSR is implicit in the source text (or expressed by means other than connectives). This method is then applied to study the French causal connectives car, parce que and puisque using a Russian-French parallel corpus. The corpus data are analysed to obtain information about LSRs particularly about cases where the causal LSR in Russian is implicit, as well as about the use of causal connectives in French. These results are used to show that the method proposed allows to quickly create a representative array of contexts with implicit LSRs, which can be useful in both text analysis and in machine learning.
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Yao, Bitao, Zude Zhou, Wenjun Xu, Yilin Fang, Luyang Shao, Qiang Wang, and Aiming Liu. "Service-Oriented Predictive Maintenance for Large Scale Machines Based on Perception Big Data." In ASME 2015 International Manufacturing Science and Engineering Conference. American Society of Mechanical Engineers, 2015. http://dx.doi.org/10.1115/msec2015-9274.

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Large scale machines (LSMs) are always crucial equipments in manufacturing. Maintaining reliability, precision and safety for LSMs is very important. However, LSMs always work under extreme condition and are prone to degradation or failure. Therefore, maintenance is important for them. Compared with preventive maintenance, predictive maintenance is cost-saving. Besides, predictive maintenance is a more sustainable way by reducing failure and enhancing safety. Condition perception is needed in predictive maintenance. Due to the complex structure and large scale of LSMs, the perception data can be characterized as Big Data. Therefore, the storage and processing of Big Data needs to be integrated into maintenance. Considering that LSMs can be distributed all over the word, cloud service can be a proper way to support maintenance in a global environment. In this paper, a framework of service-oriented predictive maintenance for LSMs based on perception Big Data is synthesized to meet those demands. The methodologies are discussed as well. Finally, an industry case is studied to illustrate the implementing of predictive maintenance.
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Ye, Tao, Danny Bickson, and Denis Parra. "LSRS'16." In RecSys '16: Tenth ACM Conference on Recommender Systems. New York, NY, USA: ACM, 2016. http://dx.doi.org/10.1145/2959100.2959206.

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Reports on the topic "LSCs"

1

Alinger, Matthew. Performance Degradation of LSCF Cathodes. Office of Scientific and Technical Information (OSTI), September 2013. http://dx.doi.org/10.2172/1132601.

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Takacs, A., L. Berger, D. Caviglia, D. Fedyk, and J. Meuric. GMPLS Asymmetric Bandwidth Bidirectional Label Switched Paths (LSPs). RFC Editor, September 2011. http://dx.doi.org/10.17487/rfc6387.

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Berger, L., A. Takacs, D. Caviglia, D. Fedyk, and J. Meuric. GMPLS Asymmetric Bandwidth Bidirectional Label Switched Paths (LSPs). RFC Editor, March 2009. http://dx.doi.org/10.17487/rfc5467.

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Widjaja, I., and A. Elwalid. Performance Issues in VC-Merge Capable ATM LSRs. RFC Editor, September 1999. http://dx.doi.org/10.17487/rfc2682.

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Ginsberg, L., S. Previdi, and Y. Yang. IS-IS Flooding Scope Link State PDUs (LSPs). RFC Editor, September 2014. http://dx.doi.org/10.17487/rfc7356.

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Decraene, B., and I. Minei. LDP Extension for Inter-Area Label Switched Paths (LSPs). RFC Editor, July 2008. http://dx.doi.org/10.17487/rfc5283.

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7

Templeton, Jared W., Zigui Lu, Jeffry W. Stevenson, and John S. Hardy. Effect of A-site Non-stoichiometry on LSCF Cathodes. Office of Scientific and Technical Information (OSTI), September 2011. http://dx.doi.org/10.2172/1036437.

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8

Aggarwal, R., K. Kompella, T. Nadeau, and G. Swallow. Bidirectional Forwarding Detection (BFD) for MPLS Label Switched Paths (LSPs). RFC Editor, June 2010. http://dx.doi.org/10.17487/rfc5884.

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9

Gavron, Victor. Does LSDS Analysis Require More Than One Isotopic Fission Chamber? Office of Scientific and Technical Information (OSTI), September 2012. http://dx.doi.org/10.2172/1052382.

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10

Jing, R. RSVP-TE Extensions for Associated Bidirectional Label Switched Paths (LSPs). Edited by F. Zhang and R. Gandhi. RFC Editor, May 2015. http://dx.doi.org/10.17487/rfc7551.

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