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Journal articles on the topic 'LSCs'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Robertson, Sarah Y. T., JoAnn S. Roberts, and Sophie X. Deng. "Regulation of Limbal Epithelial Stem Cells: Importance of the Niche." International Journal of Molecular Sciences 22, no. 21 (2021): 11975. http://dx.doi.org/10.3390/ijms222111975.

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Limbal epithelial stem/progenitor cells (LSCs) reside in a niche that contains finely tuned balances of various signaling pathways including Wnt, Notch, BMP, Shh, YAP, and TGFβ. The activation or inhibition of these pathways is frequently dependent on the interactions of LSCs with various niche cell types and extracellular substrates. In addition to receiving molecular signals from growth factors, cytokines, and other soluble molecules, LSCs also respond to their surrounding physical structure via mechanotransduction, interaction with the ECM, and interactions with other cell types. Damage to

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2

Zdraveva, Emilija, Krešo Bendelja, Luka Bočkor, Tamara Dolenec, and Budimir Mijović. "Detection of Limbal Stem Cells Adhered to Melt Electrospun Silk Fibroin and Gelatin-Modified Polylactic Acid Scaffolds." Polymers 15, no. 3 (2023): 777. http://dx.doi.org/10.3390/polym15030777.

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Limbal stem cells (LSCs) are of paramount importance in corneal epithelial tissue repair. The cornea becomes opaque in case of limbal stem cell deficiency (LSCD), which may cause serious damage to the ocular visual function. There are many techniques to restore damaged epithelium, one of which is the transplantation of healthy cultured LSCs, usually onto a human amniotic membrane or onto bio-based engineered scaffolds in recent years. In this study, melt electrospun polylactic acid (PLA) was modified by silk fibroin or gelatin and further cultured with LSCs originating from three different don

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Sudha, Kumari. "A Study to Evaluate the Rate of Caesarean Deliveries, Various Indications of the Procedure as well as the Associated Maternal Morbidity and Mortality." International Journal of Toxicological and Pharmacological Research 11, no. 6 (2021): 55–60. https://doi.org/10.5281/zenodo.12581340.

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<strong>Aim:</strong>   To evaluate the prevalence of cesarean section in a tertiary care hospital. <strong>Methods:</strong> A retrospective study on women who underwent LSCS over a period of 1 year. Department of Obstetrics and Gynecology, Katihar Medical College and Hospital,Katihar, Bihar, India .  Out of the 489 deliveries, 200 were delivered by cesarean section. Variables including age, parity, gestational age, CS timing (elective or emergency), and indications for LSCS were collected from their case records and entered in the proforma. <strong>Results:</str

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Sudha, Kumari. "A Study to Evaluate the Rate of Caesarean Deliveries, Various Indications of the Procedure as well as the Associated Maternal Morbidity and Mortality." International Journal of Toxicological and Pharmacological Research 11, no. 6 (2021): 78–83. https://doi.org/10.5281/zenodo.12581600.

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<strong>Aim:</strong>   To evaluate the prevalence of cesarean section in a tertiary care hospital. <strong>Methods:</strong> A retrospective study on women who underwent LSCS over a period of 1 year. Department of Obstetrics and Gynecology, Katihar Medical College and Hospital,Katihar, Bihar, India .  Out of the 489 deliveries, 200 were delivered by cesarean section. Variables including age, parity, gestational age, CS timing (elective or emergency), and indications for LSCS were collected from their case records and entered in the proforma. <strong>Results:</str

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Khan, Imran Ahmed, Harish Chandra Tiwari, and Najma Malik. "Factors influencing the choice of caesarean delivery and their satisfaction among pregnant women attending maternity hospital in Eastern Uttar Pradesh." Indian Journal of Community Health 35, no. 3 (2023): 329–33. http://dx.doi.org/10.47203/ijch.2023.v35i03.014.

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Introduction: The birth of a baby through the vaginal route is a traditional way of delivery. But, at times normal vaginal delivery is not desirable due to various reasons. Under such circumstances, Lower section caesarean section (LSCS) is carried out to deliver the baby safely. There are rising concerns about the increasing rate of caesarean sections with wide variations in rates across the globe. Factors that influence the decision to perform a LSCS are often complex and multifactorial. Understanding these complexities is one of many steps to help stop the rise of any unnecessary LSCSs or p

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Su, X., Y. Liu, M. Bakkar, et al. "Labial Stem Cell Extract Mitigates Injury to Irradiated Salivary Glands." Journal of Dental Research 99, no. 3 (2020): 293–301. http://dx.doi.org/10.1177/0022034519898138.

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Stem cell–based therapies could provide a permanent treatment for salivary gland (SG) hypofunction caused by ionizing radiation (IR) injury. However, current challenges for SG stem cells to reach the clinic include surgical invasiveness, amount of tissue needed, cell delivery, and storage methods. The objective of this study was to develop a clinically less invasive method to isolate and expand human SG stem cells and then to obtain a cell-free extract to be used as a therapy for IR-injured SGs. Human labial glands were biopsied, and labial stem cells (LSCs) were expanded by explant culture. T

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Li, Shuailin, Tanja Stachon, Shanhe Liu, et al. "Increased sensitivity of primary aniridia limbal stromal cells to travoprost, leading to elevated migration and MMP-9 protein levels, in vitro." PLOS One 20, no. 6 (2025): e0326967. https://doi.org/10.1371/journal.pone.0326967.

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Purpose In congenital aniridia, not only limbal epithelial cells but also limbal stromal cells may contribute to the development of aniridia associated keratopathy (AAK). Secondary glaucoma affects 50–75% of patients with congenital aniridia, and prostaglandin analogs are commonly used for conservative treatment. This study aimed to explore the effect of travoprost on corneal limbal stromal cells from healthy (LSCs) and congenital aniridia subjects (AN-LSCs), in vitro. Materials and methods Cells were extracted from aniridia (AN-LSCs) (n=7) and healthy donors (LSCs) (n=7). In culture, the cell

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Ikezoe, Takayuki, Yang Jing, Chie Nishioka, Shinsuke Kojima, Asako Takeuchi та Akihito Yokoyama. "Inhibition of STAT5 by IL-1β or the Inhibitor of Janus Kinases Stimulates Dormant Human Leukemia Stem Cells and Sensitizes Them to Anti-Leukemia Agents." Blood 114, № 22 (2009): 1597. http://dx.doi.org/10.1182/blood.v114.22.1597.1597.

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Abstract Abstract 1597 Poster Board I-623 Leukemia stem cells (LSCs) are in a quiescent state, which maybe contributes to their drug-resistant character. It is essential to eradicate LSCs to develop curative therapy for leukemia. To verify molecular mechanisms by which LSCs maintain a dormant state, we examined the activity of the major pro-survival signal pathways in LSCs (CD34+/CD38- compartment) and non-LSCs (CD34+/CD38+ compartment) counterparts from patients with acute myelogenous leukemia (AML, n=3) and acute lymphoblastic leukemia (ALL, n=1) by FACS. Interestingly, LSCs compartment expr

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Amrein, Michael A., Elias D. Bührer, Stefan Forster, et al. "Splenic CD24low Red Pulp Macrophages Provide an Alternate Niche for Chronic Myeloid Leukemia Stem Cells." Blood 134, Supplement_1 (2019): 1634. http://dx.doi.org/10.1182/blood-2019-126593.

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Chronic myeloid leukemia (CML) is a typical stem-cell driven malignancy, driven by leukemia stem cells (LSCs). LSCs are resistant to conventional therapies. This resistance is mediated by cell-intrinsic mechanisms and interactions with the microenvironment. LSCs depend on signals from a specialized microenvironment, a so called niche, to maintain their stem cell characteristics. In CML the bone marrow (BM) as a niche is well-investigated and several therapeutic targets, which aim at LSCs by interrupting their interaction with the BM-niche are under investigation. However, even though splenomeg

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Sharma, Neelam, and Anshul Jhanwar. "Study of incidence, trends and determinants of caesarean section in tertiary care hospital of Rajasthan, India." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 7, no. 7 (2018): 2672. http://dx.doi.org/10.18203/2320-1770.ijrcog20182504.

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Background: Lower Segment Caesarean section (LSCS) is recommended when vaginal delivery might pose a risk to the mother or baby. Worldwide rise in LSCS rate during the last three decades, has been the cause of alarm and needs an in-depth study.Methods: It was a retrospective, observational study conducted in Obstetrics and Gynecology department of Jhalawar medical college, Jhalawar. Data were obtained from medical record database of patients admitted for deliveries from October 2017 to March 2018 over period of six months. The total number of patients delivered and the number of LSCS done were

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Satake, Noriko, Connie Duong, Sakiko Yoshida, et al. "Leukemia Stem Cells in Acute Lymphoblastic Leukemia: Unveiling Hierarchical Structure at Single Cell Resolution." Blood 124, no. 21 (2014): 4786. http://dx.doi.org/10.1182/blood.v124.21.4786.4786.

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Abstract Leukemia stem cells (LSCs) are the root of leukemia, and are responsible for drug resistance and disease relapse. However, LSCs have not yet been identified for acute lymphoblastic leukemia (ALL). Among many challenges, lack of phenotypic markers is one of the major problems in identifying ALL LSCs. In this study, we demonstrated a novel method to isolate LSCs from both T- and B- cell ALLs and further characterized their transcriptome profile at the single cell level. We have recently identified a novel method to isolate ALL LSCs based on cellular metabolic activities. We demonstrated

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Buss, Ray R., and James G. Allen. "Leader Scholar Communities: Supporting EdD Students’ Dissertation in Practice Efforts." Impacting Education: Journal on Transforming Professional Practice 5, no. 3 (2020): 1–7. http://dx.doi.org/10.5195/ie.2020.98.

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In this essay, we discuss Leader Scholar Communities (LSCs), which have proven to be helpful in supporting students’ dissertation in practice (DiP) efforts in several CPED-guided programs. We have organized this essay around four important topics including (a) describing a theoretical framework that serves as the foundation for LSCs, (b) providing a rationale for using LSCs, (c) illustrating how LSCs have been implemented to support students’ DiP efforts in our EdD programs, and (d) exploring the benefits and limitations of LSCs. We have also presented research information about graduates’ per

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Klyuchnikov, Evgeny, Anita Badbaran, Radwan Massoud, et al. "Leukemic Stem Cells (LSCs) As Peri-Transplant MRD Assessment in AML Patients Undergoing Allogeneic Stem Cell Transplantation in CR." Blood 142, Supplement 1 (2023): 1588. http://dx.doi.org/10.1182/blood-2023-188998.

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Background: Several studies have shown that the leukemic stem cells (LSCs: CD34 +CD38 -CD45RA +/Combi-6 +) play a crucial role in the development of relapses in AML patients (pts). LSCs are less sensitive to conventional therapy; moreover, their phenotypical characteristics may allow immune evasion promoting relapses after allo-SCT. Although ELN guidelines recommend including LSCs into MRD assessment, this approach has not yet been studied extensively in the allogeneic setting. Here we suggested that peri-transplant LSCs detection may provide additional prognostic information to conventional (

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Imai, Takaya, Sota Nagai, Takehiro Michikawa, et al. "Impact of Lumbar Surgery on Pharmacological Treatment for Patients with Lumbar Spinal Canal Stenosis: A Single-Center Retrospective Study." Journal of Clinical Medicine 12, no. 6 (2023): 2385. http://dx.doi.org/10.3390/jcm12062385.

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Treatment for lumbar spinal canal stenosis (LSCS) is mainly classified into conservative and surgical therapies. Among conservative therapies, pharmacological treatment is commonly prescribed for LSCS. Meanwhile, surgical treatment is the last option for LSCS. This study aimed to examine the impact of lumbar surgery on pharmacological treatment for patients with LSCS. Consecutive patients aged ≥ 40 years who underwent lumbar surgery for LSCS were identified. A total of 142 patients were retrospectively reviewed for preoperative and 6-month and 1-year postoperative LSCS medications. The results

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Zhang, Haojian, Huawei Li та Shaoguang Li. "HIF1α Is Required for Survival Maintenance of Chronic Myeloid Leukemia Stem Cells". Blood 118, № 21 (2011): 449. http://dx.doi.org/10.1182/blood.v118.21.449.449.

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Abstract Abstract 449 Chronic myeloid leukemia (CML) is a clonal hematopoietic stem cell disorder induced by the BCR-ABL oncogene, and available BCR-ABL kinase inhibitors fail to completely eradicate leukemia stem cells (LSCs) to cure the disease. The challenge lies in the identification of genes that play a critical role in survival regulation of LSCs. Hypoxia-inducible factor-1α (HIF1α), a master transcriptional regulator of the cellular and systemic hypoxia response, is essential for the maintenance of self-renewal capacity of normal hematopoietic stem cells (HSCs). It is still unknown abou

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Zhang, Haojian, Huawei Li, Hualin S. Xi та Shaoguang Li. "HIF1α is required for survival maintenance of chronic myeloid leukemia stem cells". Blood 119, № 11 (2012): 2595–607. http://dx.doi.org/10.1182/blood-2011-10-387381.

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Abstract Hypoxia-inducible factor-1α (HIF1α), a master transcriptional regulator of the cellular and systemic hypoxia response, is essential for the maintenance of self-renewal capacity of normal HSCs. It is still unknown whether HIF1α has a role in survival regulation of leukemia stem cells (LSCs) in chronic myeloid leukemia (CML). Using a mouse model of CML, here we report that HIF1α plays a crucial role in survival maintenance of LSCs. Deletion of HIF1α impairs the propagation of CML through impairing cell-cycle progression and inducing apoptosis of LSCs. Deletion of HIF1α results in elevat

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Gezer, Deniz, Amelie V. Guitart, Milica Vukovic та ін. "HIF-1α Is Not Essential For The Establishment Of MLL-Leukaemic Stem Cells". Blood 122, № 21 (2013): 3767. http://dx.doi.org/10.1182/blood.v122.21.3767.3767.

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Abstract Haematopoietic stem cells (HSCs) reside in hypoxic niches in the bone marrow (BM) and sustain long-life haematopoiesis. HSCs are largely quiescent, self-renew, undergo apoptosis and generate progenitor cells, which differentiate to multiple blood lineages. The strict regulation of the balance between these fate decisions is essential for haematopoiesis and their dysregulation in HSCs and progenitor cells can result in leukaemic transformation. HSCs and leukemic stem cells (LSCs) are suggested to share the same niche and are in need to adapt to hypoxic conditions. Hypoxia-inducible-fac

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Reshita. "Observational Research to Find the Rate of Caesarean Deliveries and Various Indications of the Procedure." International Journal of Current Pharmaceutical Review and Research 15, no. 01 (2023): 89–95. https://doi.org/10.5281/zenodo.12654702.

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AbstractAim: The aim of the present study was to find the rate of caesarean deliveries and variousindications of the procedure.Methods: The Department of Obstetrics and Gynecology of Patna medical College andHospital, Patna, Bihar, India conducted this retrospective study on women who underwentLSCS over a period of 11 Months. Out of the 935 deliveries, 500 were delivered by cesareansection. All the mothers who underwent LSCS in this hospital in the designated period wereincluded in this study.Results: The LSCS prevalence was 53.47% in our institution. We have assessed the commonindications of

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Liu, Shanhe, Shuailin Li, Shao-Lun Hsu, et al. "Altered Bcl-2/Caspase signaling and hypoxia-induced apoptosis in primary human aniridia limbal stromal cells, in CoCl2 mediated hypoxic stress, in vitro." PLOS One 20, no. 7 (2025): e0328157. https://doi.org/10.1371/journal.pone.0328157.

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Purpose The aim of this study was to investigate apoptosis in primary aniridia limbal stromal cells (LSCs) and to assess changes in the expression of genes and proteins associated with the apoptotic pathway in response to cobalt chloride (CoCl2)-induced hypoxic stress, in vitro. Methods Primary human limbal stromal cells were isolated from the limbal region of both aniridia (AN-LSCs; n = 8) and healthy (LSCs; n = 8) donors. The cells were treated with 0 µM, 50 µM, and 75 µM CoCl2 for 48 hours. Apoptosis in each group was assessed by Flow cytometry (FC). The expression levels of apoptosis-relat

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Khan, Mehak Asim, Irum Sohail, and Maria Habib. "Auditing the cesarean section rate by Robson’s ten group classification system at Tertiary Care Hospital." Professional Medical Journal 27, no. 04 (2020): 700–706. http://dx.doi.org/10.29309/tpmj/2020.27.04.3383.

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Objectives: To analyze the trends of cesarean sections, categorize them into Robson’s Ten Group Classification System (RTGCS), to identify the groups contributing the most to overall lower segment cesarean section (LSCS) rate and to formulate strategies for reducing these rates. Study Design: Cross sectional population based study. Setting: Gynecology and Obstetrics Department of Kahuta Research Laboratories (KRL) hospital, Islamabad. Period: From 1st Nov, 2017 to 30th April, 2018. Material & Methods: The births during this period were distributed into the RTGCS on the basis of past obstet

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Zhang, Haojian, and Shaoguang Li. "The Scd1 Gene Functions as a Tumor Suppressor In Leukemia Stem Cells." Blood 116, no. 21 (2010): 201. http://dx.doi.org/10.1182/blood.v116.21.201.201.

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Abstract Abstract 201 We have previously shown that the arachidonate 5-lipoxygenase gene (Alox5) functions as a critical regulator of leukemia stem cells (LSCs) in BCR-ABL-induced chronic myeloid leukemia (CML) in mice. The Alox5 pathway appears to represent a major molecular network in LSCs. Taking advantage of our DNA microarray analysis for the identification of critical genes regulated by BCR-ABL in LSCs, we identified a small group of candidate genes that likely play tumor suppressor roles in these stem cells, and among them, a gene called stearoyl-CoA desaturase 1 (Scd1), an endoplasmic

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Jones, Courtney L., Brett M. Stevens, Angelo D'Alessandro, et al. "Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells." Blood 132, Supplement 1 (2018): 1521. http://dx.doi.org/10.1182/blood-2018-99-111965.

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Abstract Outcomes for AML patients remain poor because of the inability to fully eliminate leukemia stem cells (LSCs). We have previously shown that primary human LSCs reside in a unique metabolic condition characterized by a relatively low oxidative state (termed "ROS-low") and increased levels of glutathione (Lagadinou et al. Cell Stem Cell, 2013). Cells in this condition are highly dependent on oxidative phosphorylation (OXPHOS) for survival, in striking contrast to many tumor cells which often rely on glycolysis, suggesting that LSCs are governed by distinct metabolic properties. Therefore

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Hansen, Quinty, Costa Bachas, Linda Smit, and Jacqueline Cloos. "Characteristics of leukemic stem cells in acute leukemia and potential targeted therapies for their specific eradication." Cancer Drug Resistance 5, no. 2 (2022): 344–67. http://dx.doi.org/10.20517/cdr.2021.140.

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In acute myeloid leukemia (AML), a small cell population that contains stem cell features such as lack of differentiation, self-renewal potential, and drug resistance, can be identified. These so-called leukemic stem cells (LSCs) are thought to be responsible for relapse initiation after initial treatment leading to successful eradication of the bulk AML cell population. Since many studies have aimed to characterize and eliminate LSCs to prevent relapse and increase survival rates of patients, LSCs are one of the best characterized cancer stem cells. The specific elimination of LSCs, while spa

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Sonal and Heidi Sinha Hemali. "Determining the Rate of Caesarean Deliveries and Various Indications of the Procedure: Retrospective Study." International Journal of Current Pharmaceutical Review and Research 16, no. 2 (2024): 286–90. https://doi.org/10.5281/zenodo.12739755.

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Aim: The aim of the present study was to find the rate of caesarean deliveries and various indications of theprocedure.Methods: The present study was conducted in the Department of Obstetrics and Gynecology conducted thisretrospective study on women who underwent LSCS over a period of 14 months. Out of the 445 deliveries, 200were delivered by cesarean section. All the mothers who underwent LSCS in this hospital in the designated periodwere included in this study.Results: The LSCS prevalence was 44.94% in our institution. We have assessed the common indications of LSCSperformed in this study po

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Mirza, K., J. Austine, J. Chopra, et al. "PREGNANCY AND IDIOPATHIC SCOLIOSIS: A TEN-YEAR COMPARATIVE REVIEW OF INTRA-PARTUM OUTCOMES." Orthopaedic Proceedings 106-B, SUPP_20 (2024): 8. https://doi.org/10.1302/1358-992x.2024.20.008.

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ObjectivesTo determine whether patients with scoliosis, treated with or without surgery, are at higher risk of needing caesarean section. To determine whether patients with scoliosis, treated with or without surgery, have increased intra-partum obstetric analgesic requirements.Design and MethodsRetrospective cohort study wherein obstetric outcomes were analysed in women with scoliosis in a tertiary teaching hospital. Women with scoliosis were identified using the high-risk obstetric anaesthesia register. Data was collected between May 2013 to April 2023.ResultsWe identified 39 women with corre

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Riether, Carsten, Ramin Radpour, Chantal L. Bachmann, et al. "CD93-Signaling Regulates Self-Renewal and Proliferation of Chronic Myeloid Leukemia Stem Cells in Mice and Humans and Might be a Promising Target for Treatment." Blood 134, Supplement_1 (2019): 187. http://dx.doi.org/10.1182/blood-2019-127864.

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Background: The introduction of BCR/ABL-specific tyrosine kinase inhibitors (TKIs) more than two decades ago revolutionized chronic myelogenous leukemia (CML) therapy. The majority of CML patients treated with TKIs obtain durable cytogenetic and molecular responses. However, only a subgroup of these patients can successfully discontinue TKI therapy and maintain a treatment-free remission (Laneuville et al. 2011). TKI-resistant leukemia stem cells (LSCs) persist in the majority of patients at low levels over a prolonged period. These quiescent, self-renewing LSCs in the BM are the major cause o

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Rondeau, Vincent, Rachel Culp-Hill, Julie A. Reisz, et al. "Polyamines Are Required for AML LSC Function through Their Role in Regulating eIF5A Dependent Protein Synthesis." Blood 142, Supplement 1 (2023): 585. http://dx.doi.org/10.1182/blood-2023-187283.

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Outcomes for patients with acute myeloid leukemia (AML) remain poor due to the inability of current therapies to fully eradicate disease initiating leukemia stem cells (LSCs) (Shlush et al., 2017). Many studies have demonstrated that LSCs have unique metabolic properties compared to AML blasts and normal hematopoietic stem and progenitor cells (HSPCs) (Jones et al., 2021). In this study we sought to quantify metabolite levels in LSCs compared to HSPCs using an unbiased metabolites screen. To examine metabolite levels in enriched LSCs and HSPCs we used mass spectrometry-based metabolomics analy

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Wang, Lu-Kai, Tsai-Jung Wu, Ji-Hong Hong, et al. "Radiation Induces Pulmonary Fibrosis by Promoting the Fibrogenic Differentiation of Alveolar Stem Cells." Stem Cells International 2020 (September 29, 2020): 1–12. http://dx.doi.org/10.1155/2020/6312053.

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The lung is a radiosensitive organ, which imposes limits on the therapeutic dose in thoracic radiotherapy. Irradiated alveolar epithelial cells promote radiation-related pneumonitis and fibrosis. However, the role of lung stem cells (LSCs) in the development of radiation-induced lung injury is still unclear. In this study, we found that both LSCs and LSC-derived type II alveolar epithelial cells (AECII) can repair radiation-induced DNA double-strand breaks, but the irradiated LSCs underwent growth arrest and cell differentiation faster than the irradiated AECII cells. Moreover, radiation drove

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Cordeiro, Giovana, Pedro Pechorro, Bruno Bonfá-Araujo, Manuel D. Gonçalves, and Mário R. Simões. "Uma comparação de duas escalas de autocontrole na predição de atos antissociais/criminais." Interamerican Journal of Forensic Psychology 1, no. 1 (2024): 17–28. https://doi.org/10.35168/2966-3466.utp.ijfp.y.vol1.n1.pp17-28.

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O autocontrole é uma característica estável cuja variação a nível individual é crucial na compreensão da propensão criminal, sendo a Low Self-Control Scale (LSCS) e a Brief Self-Control Scale (BSCS) as escalas de autocontrole mais utilizadas. Este estudo teve como objetivo comparar a LSCS e BSCS no contexto das suas capacidades preditivas de comportamentos antissociais/criminais, violência, problemas com a lei, detenção, prisão e abuso de álcool e drogas. Foi utilizada uma amostra de conveniência, coletada em Portugal, composta por 242 participantes (M = 30,19 anos; DP = 12,78; amplitude = 16-

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DK, Rajshree. "A Study on the Fetomaternal Outcome in Cases of Previous Three Caesarean Section." Open Access Journal of Gynecology 3, no. 3 (2018): 1–6. http://dx.doi.org/10.23880/oajg-16000162.

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Introduction: Caesarean section is the most common obstetrical surgery performed worldwide. Its incidence continuously rising. The rate of caesarean section is 24.4% in urban educated India. In our college LSCS rate of previous 5 years is 25.4%, amongst which 0.2% were previous three LSCS. Methodology: A retrospective observational stu dy of 200 cases of caesarean deliveries from January 2010 to December 2017 in a tertiary care centre. Cases were divided in four groups such as first LSCS, second LSCS, third LSCS and fourth LSCS, each group contained 50 cases. Results: Patients were group ed as

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Ho, Jenny M., Stephanie M. Dobson, Jessica McLeod, et al. "Isolation of CD34− and CD34+ Leukemia Stem Cells from Acute Myeloid Leukemia Blasts Using CD200." Blood 132, Supplement 1 (2018): 2790. http://dx.doi.org/10.1182/blood-2018-99-119318.

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Abstract Therapy resistance and relapse in acute myeloid leukemia (AML) are driven by leukemia stem cells (LSCs). Recent evidence highlighting functional and genetic heterogeneity among LSC subclones underscores the importance of capturing the entire LSC compartment in studies of LSC biology. Although LSCs are often enriched in the CD34+CD38- cell fraction, they are frequently detected in other phenotypic fractions, and in some cases are restricted to the CD34- population. In order to discover novel LSC markers, we examined genes differentially expressed between functionally-validated LSC+ and

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Zhai, Xingjian, and Xiaoyan Jiang. "Properties of Leukemic Stem Cells in Regulating Drug Resistance in Acute and Chronic Myeloid Leukemias." Biomedicines 10, no. 8 (2022): 1841. http://dx.doi.org/10.3390/biomedicines10081841.

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Notoriously known for their capacity to reconstitute hematological malignancies in vivo, leukemic stem cells (LSCs) represent key drivers of therapeutic resistance and disease relapse, posing as a major medical dilemma. Despite having low abundance in the bulk leukemic population, LSCs have developed unique molecular dependencies and intricate signaling networks to enable self-renewal, quiescence, and drug resistance. To illustrate the multi-dimensional landscape of LSC-mediated leukemogenesis, in this review, we present phenotypical characteristics of LSCs, address the LSC-associated leukemic

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Jiang, Xiaoyan. "Toward distinguishing LSCs from HSCs." Blood 110, no. 7 (2007): 2222–23. http://dx.doi.org/10.1182/blood-2007-07-100990.

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LSCs make up a critical, but very rare, population that is very difficult to study in vivo. Neering and colleagues developed a unique mouse model system in which the properties of human LSCs are closely mimicked during CML development.

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Wang, Yu-Hung, Chien-Chin Lin, Chi-Yuan Yao, et al. "A 4-gene leukemic stem cell score can independently predict the prognosis of myelodysplastic syndrome patients." Blood Advances 4, no. 4 (2020): 644–54. http://dx.doi.org/10.1182/bloodadvances.2019001185.

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Abstract Myelodysplastic syndrome (MDS) comprised a heterogeneous group of diseases. The prognosis of patients varies even in the same risk groups. Searching for novel prognostic markers is warranted. Leukemic stem cells (LSCs) are responsible for chemoresistance and relapse in leukemia. Recently, expressions of 17 genes related to stemness of LSCs were found to be associated with prognosis in acute myeloid leukemia patients. However, the clinical impact of LSC genes expressions in MDS, a disorder arising from hematopoietic stem cells, remains unclear. We analyzed expression profile of the 17

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Li, Hongqiao, and Matthias S. Ullrich. "Characterization and Mutational Analysis of Three Allelic lsc Genes Encoding Levansucrase inPseudomonas syringae." Journal of Bacteriology 183, no. 11 (2001): 3282–92. http://dx.doi.org/10.1128/jb.183.11.3282-3292.2001.

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ABSTRACT In the plant pathogen Pseudomonas syringaepv. glycinea PG4180 and other bacterial species, synthesis of the exopolysaccharide levan is catalyzed by the extracellular enzyme levansucrase. The results of Southern blotting and PCR analysis indicated the presence of three levansucrase-encoding genes in strain PG4180: lscA, lscB, andlscC. In this study, lscB andlscC were cloned from a genomic library of strain PG4180. Sequence analysis of the two lsc genes showed that they were virtually identical to each other and highly similar to the previously characterized lscA gene.lscA and lscC had

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Rowe, R. Grant, George Q. Daley, Trista E. North, et al. "Mechanisms of Leukemia Stem Cell Plasticity Revealed By Single Cell Analysis." Blood 136, Supplement 1 (2020): 32. http://dx.doi.org/10.1182/blood-2020-135998.

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Leukemia stem cells (LSCs) are the subset of leukemic cells that drive leukemia progression, resist therapy, and remain latent to spark disease relapse. LSCs are quantified by efficiency of xenografting immunodeficient mice, a measurement that is predictive of leukemia outcome. Although LSCs have been previously thought to be rare and phenotypically primitive, recent data indicate that LSCs may actually be heterogeneous. Here, we use single-cell transcriptomics combined with limiting dilution xenotransplantation to dissect the ontogeny of MLL-rearranged B-lymphoblastic leukemia (MLL-r B-ALL),

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Kohare, Chaitali Y., Amrita J. Jain, and Ruchita B. Jadhao. "Analysis of trial of labour in previous one LSCS and its correlation with maternal and fetal outcome." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 14, no. 3 (2025): 843–46. https://doi.org/10.18203/2320-1770.ijrcog20250515.

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Background: A rise in caesarean rate worldwide is one of the causes of maternal and perinatal mortality as well as morbidity. The goal of present study was to assess maternal and fetal outcome of patients with previous one LSCS who were given trial of labour. This research aimed to study the incidence of VBAC and repeat CS in cases with previous one LSCS. And to compare the fetomaternal outcome between vaginal and repeat caesarean delivery. Also, to discover factors predicting outcome of trial of labour after previous one caesarean delivery. Methods: In this prospective observational study in

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Li, Shaoguang, Yiguo Hu, Yaoyu Chen, and Lori Douglas. "Beta-catenin Is Essential for Survival of Leukemia Stem Cells Insensitive to Kinase Inhibition in Mice with BCR-ABL Induced Chronic Myeloid Leukemia." Blood 112, no. 11 (2008): 1080. http://dx.doi.org/10.1182/blood.v112.11.1080.1080.

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Abstract Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) induced by the BCR-ABL oncogene is believed to be developed from leukemic stem cells (LSCs), and we have previously shown in mice that LSCs for CML express the same cell surface markers that are also expressed on normal hematopoietic stem cells. Although the inhibition of BCR-ABL kinase activity by imatinib is highly effective in treating human Ph+ CML in chronic phase, it is difficult to achieve molecular remission of the disease, suggesting that LSCs remain in patients. In this study, we find that following imatin

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Yang, Xiangchou, Rongxin Yao, and Hong Wang. "Update of ALDH as a Potential Biomarker and Therapeutic Target for AML." BioMed Research International 2018 (2018): 1–5. http://dx.doi.org/10.1155/2018/9192104.

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Studies employing mouse transplantation have illustrated the role of aldehyde dehydrogenase (ALDH) defining hematopoietic stem cells (HSCs) and leukemia stem cells (LSCs). Besides being a molecular marker, ALDH mediates drug resistance in AML, which induces poor prognosis of the patients. In AML patients, either CD34+ALDHbrpopulation or CD34+CD38−ALDHintpopulation was found to denote LSCs and minimal residual disease (MRD). A bunch of reagents targeting ALDH directly or indirectly have been evaluated. ATRA, disulfiram, and dimethyl ampal thiolester (DIMATE) are all shown to be potential candid

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Jiang, Yuelong, Long Liu, Yirong Jiang, et al. "Preclinical Evaluation of the Multiple Tyrosine Kinases Inhibitor Anlotinib in Leukemia Stem Cells." Pharmaceuticals 15, no. 11 (2022): 1313. http://dx.doi.org/10.3390/ph15111313.

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Leukemia stem cells (LSCs) constitute the critical barrier to the cure of acute myeloid leukemia (AML) due to their chemoresistance and immune evasion property. Herein, the role of anlotinib, a multiple tyrosine kinase inhibitor, in killing LSCs and regulating chemoresistance and immune evasion was explored. Anlotinib treatment induced apoptosis of LSC-like cells as well as primary AML LSCs, while sparing the normal mononuclear cells in vitro. Moreover, anlotinib could impair the regeneration capacity of LSCs in the patient-derived leukemia xenograft mouse model. Mechanistically, anlotinib inh

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Si, Xiaohui, Xiaoyun Zhang, Xing Hao, et al. "Upregulation of Mir-99a Is Associated with Poor Prognosis of Acute Myeloid Leukemia and Promotes Myeloid Leukemia Cell Expansion." Blood 128, no. 22 (2016): 5086. http://dx.doi.org/10.1182/blood.v128.22.5086.5086.

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Abstract Acute myeloid leukemia (AML) is a hereditarily and clinically heterogeneous disease driven by a subpopulation of leukemic stem cells (LSCs) that generate the bulk of leukemic cells. LSCs can resist available treatments and result in disease progression and relapse. High number of LSCs or expression of a LSC related gene signature is independently associated with poor prognosis in AML, supporting the notion for LSCs as important targets for therapeutic intervention. It is now evident that miRNAs contribute significantly to the leukemogenic phenotype. To dissect the miRNA expression pro

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Sicuranza, Anna, Donatella Raspadori, and Monica Bocchia. "CD26/DPP-4 in Chronic Myeloid Leukemia." Cancers 14, no. 4 (2022): 891. http://dx.doi.org/10.3390/cancers14040891.

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CD26 expression is altered in many solid tumors and hematological malignancies. Recently, it has been demonstrated that it is a specific marker expressed on LSCs of CML, both in BM and PB samples, and absent on CD34+/CD38− stem cells in normal subjects or on LSCs of other myeloid neoplasms. CD26+ LSCs have been detected by flow-cytometry assays in all PB samples of Chronic-Phase CML patients evaluated at diagnosis. Additionally, it has been demonstrated that most CML patients undergoing Tyrosine Kinase Inhibitors (TKIs) treatment still harbored circulating measurable residual CD26+ LSCs, even

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Singh, Priya T., Karishma Salana, and Meetali Nehate. "Incidence of decision to delivery interval delay in emergency LSCS and its impact on fetal and maternal outcome: a prospective observational study." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 13, no. 4 (2024): 1002–7. http://dx.doi.org/10.18203/2320-1770.ijrcog20240803.

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Background: Caesarean delivery is a complex multidisciplinary procedure. Decision to delivery interval is supposed to play a significant role in maternal and neonatal outcomes. The present study was undertaken to determine the incidence of DDI delay among pregnant women undergoing Emergency LSCS in tertiary care centres. Methods: This study was conducted on 400 subjects who underwent emergency LSCS in category I and category II during a period from November 2020 to August 2021. Results: The maximum patients were from the age group of 25-29 years (43%), primigravida (59.1%), gestational age bet

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Neitzel, Anne-Christin, Eckhard Stamer, Wolfgang Junge, and Georg Thaller. "Evaluation of different lactation curve models fitted for milk viscosity recorded by an automated on-line California Mastitis Test." Journal of Dairy Research 82, no. 2 (2015): 185–92. http://dx.doi.org/10.1017/s0022029915000035.

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Laboratory somatic cell count (LSCC) records are usually recorded monthly and provide an important information source for breeding and herd management. Daily milk viscosity detection in composite milking (expressed as drain time) with an automated on-line California Mastitis Test (CMT) could serve immediately as an early predictor of udder diseases and might be used as a selection criterion to improve udder health. The aim of the present study was to clarify the relationship between the well-established LSCS and the new trait,‘drain time’, and to estimate their correlations to important produc

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Sailakshmi, M. P. A., and Vidhyadhare G. S. "Retrospective study of maternal and neonatal outcome in second stage lower segment caesarean section in a tertiary hospital." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 9, no. 12 (2020): 4924. http://dx.doi.org/10.18203/2320-1770.ijrcog20205222.

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Background: Caesarean section at second stage are increasing and are associated with significant maternal morbidity. The overall caesarean section rates are also increasing from last two decades.Methods: A retrospective study conducted in Department of Obstetrics and Gynaecology, Raja Rajeswari Medical College and Hospital, Bangalore from January 2018 to July 2019. Second stage LSCS were analysed in terms of indications, intraoperative and post-operative complications, neonatal morbidity.Results: In our hospital during study period there were 2639 deliveries and total number of LSCS 1146 (43.4

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Shalini, Garg, Kaur Parneet, Kaur Balwinder, Pal Kaur Satinder, Aggarwal Sangeeta, and Narula Aarti. "Maternal Outcome in Elective Vs Emergency Caesarean Section at A Tertiary Care Center." International Journal of Pharmaceutical and Clinical Research 15, no. 8 (2023): 1537–43. https://doi.org/10.5281/zenodo.11528473.

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<strong>Objective:</strong> To study the maternal outcome in elective vs emergency caesarean section at a tertiary care center. <strong>Material and Method:</strong> The study was conducted for one year. Patients irrespective of gestation age undergoing caesarean sections at our tertiary referral center were enrolled. The study was conducted after obtaining the approval of the institutional ethics committee. In this study two groups of pregnant females were studied. Group 1: Women who underwent elective caesarean section. Group 2: Women who underwent emergency caesarean section.

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Sheth, Anagha Inguva, Krysta Engel, Hunter Tolison, et al. "Targeting Mitochondrial Calcium Uptake to Eradicate Venetoclax-Resistant Acute Myeloid Leukemia Stem Cells." Blood 142, Supplement 1 (2023): 588. http://dx.doi.org/10.1182/blood-2023-188285.

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Introduction Previously, we demonstrated that human leukemia stem cells (LSCs) are preferentially reliant on oxidative phosphorylation (OXPHOS) for survival. Furthermore, inhibition of BCL2 with venetoclax (ven) acts to suppress OXPHOS, leading to the eradication of LSCs. While the activity of ven in targeting LSCs is well-established, nearly all patients eventually develop disease that is resistant to treatment. Thus, in the present study, we sought to better understand the biological properties of ven-resistant LSCs. We reasoned that the expression of known BCL2 interacting proteins in ven-s

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MUSSARAT, NAZIA, SAIMA QURASHI, and MAHNAZ ROOHI. "LOWER SEGMENT CESAREAN SECTION (LSCS);." Professional Medical Journal 20, no. 06 (2013): 916–23. http://dx.doi.org/10.29309/tpmj/2013.20.06.1737.

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Introduction: Caesarean section is one of the commonly performed surgical procedures in obstetric and is certainly one ofthe oldest operations in surgery. Recently there has been a dramatic rise in the caesarean section rate world wide especially in thedeveloped countries. As primary caesarean deliveries contributed most to the overall caesarean section rate (CSR). So this is clear thatprimary caesarean section is an important target for reduction because it leads to an increased risk for repeat caesarean delivery.Objectives: To have an overview of fetomaternal indications for LSCS at a teachi

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Truitt, Luke, Catherine Hutchinson, Karen Mochoruk, John F. DeCoteau, and C. Ronald Geyer. "Chaetocin Anti-Leukemia Activity Against Chronic Myelogenous Leukemia Stem Cells Is Potentiated By Bone Marrow Stromal Factors and Overcomes Innate Imatinib Resistance." Blood 124, no. 21 (2014): 4517. http://dx.doi.org/10.1182/blood.v124.21.4517.4517.

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Abstract Chronic myelogenous leukemia (CML) is maintained by a minor population of leukemic stem cells (LSCs) that exhibit innate resistance to tyrosine kinase inhibitors (TKIs) targeting BCR-ABL. Innate resistance can be induced by cytokines and growth factors secreted by bone marrow stromal cells (BMSFs) that protect CML-LSCs from TKIs, resulting in minimal residual disease. Developing therapies that can be combined with TKIs to eradicate TKI-insensitive CML-LSCs, is critical for disrupting innate TKI resistance and preventing disease relapse. Cancer cells balance reactive oxygen species (RO

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Dr, Dhanashri A. Patil. "Comparative Study of Maternal and Neonatal Outcomes in Second Stage LSCS Vs First Stage LSCS in Tertiary Care Centre." International Journal of Medical and Pharmaceutical Research 4, no. 2 (2023): 625–32. https://doi.org/10.5281/zenodo.7899905.

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<strong>Introduction</strong>: Caesarean section is probably the most common surgical procedure carried out in obstetrics. The rates of caesarean sections have risen steadily in the past few decades. Caesarean section in the second stage of labour is a more challenging surgical procedure and has adverse feto-maternal outcomes than performed in the first stage or before labour. The present study was done at our tertiary care centre to compare complications of Caesarean Section in the First Stage and Second Stage of Labour and the strategy to reduce maternal and neonatal complications. <strong>O

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