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Journal articles on the topic 'LTNP'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Ayala-Suárez, Rubén, Francisco Díez-Fuertes, Esther Calonge, et al. "Insight in miRNome of Long-Term Non-Progressors and Elite Controllers Exposes Potential RNAi Role in Restraining HIV-1 Infection." Journal of Clinical Medicine 9, no. 8 (2020): 2452. http://dx.doi.org/10.3390/jcm9082452.

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Long-term non-progressors (LTNP) and elite controllers (EC) represent spontaneous natural models of efficient HIV-1 response in the absence of treatment. The main purposes of this work are to describe the miRNome of HIV-1 infected patients with different extreme phenotypes and identify potentially altered pathways regulated by differentially expressed (DE) miRNAs. The miRNomes from peripheral blood mononuclear cells (PBMCs) of dual phenotype EC-LTNP or LTNP with detectable viremia and HIV-infected patients with typical progression before and after treatment, were obtained through miRNA-Seq and

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Swathirajan, Chinnambedu Ravichandran, Ramachandran Vignesh, Greer Waldrop, et al. "HIV-specific T-cell Responses and Generalized Activation in HIV-1 Infected Long-term Non-progressors and Progressors from South India." Current HIV Research 16, no. 4 (2019): 302–14. http://dx.doi.org/10.2174/1570162x17666181212122607.

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Background:Anti-viral cytokine expressions by cytotoxic T-cells and lower activation rates have been reported to correlate with suppressed HIV replication in long-term non-progressors (LTNP). Immune mechanisms underlying disease non-progression in LTNP might vary with HIV-1 subtype and geographical locations.Objective:This study evaluates cytokine expression and T-cells activation in relation to disease non-progression in LTNP.Methods:HIV-1 Subtype C infected LTNP (n=20) and progressors (n=15) were enrolled and flowcytometry assays were performed to study HIV-specific CD8 T-cells expressing IL

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3

Michel, Katherine Gisella, Bing Ma, Kathleen Weber, et al. "4117 UNIQUE VAGINAL MICROBIOME POPULATIONS AND MICROBIAL GENE CONTENT AMONG WOMEN WHO NATURALLY CONTROL HIV PROGRESSION." Journal of Clinical and Translational Science 4, s1 (2020): 20–21. http://dx.doi.org/10.1017/cts.2020.102.

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OBJECTIVES/GOALS: The role of the vaginal microbiome (VM) in HIV disease progression is poorly understood. We examined VMs of HIV+ Elite Controllers (ECs) and HIV+ Long-Term Non-Progressors (LTNPs) compared to controls: HIV-positive antiretroviral (ARV) treated (HIV+ATs) and HIV-negative women in the Women’s Interagency HIV Study (DC/Chicago/Atlanta sites). METHODS/STUDY POPULATION: VMs were surveyed via both V3/V4 region of 16S rRNA gene amplicon sequencing and metagenomics sequencing in 67 women across 4 study groups: 1) LTNPs (CD4 >500 cells/mL for 5+ years without ARVs) (n = 7) and 2) E

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Panoutsakopoulou, Vily, Kathryn Hunter, Thomas G. Sieck, Elizabeth P. Blankenhorn, and Kenneth J. Blank. "Genetic Regulation of Long-Term Nonprogression in E-55+ Murine Leukemia Virus Infection in Mice." Journal of Virology 73, no. 11 (1999): 9232–36. http://dx.doi.org/10.1128/jvi.73.11.9232-9236.1999.

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ABSTRACT Certain inbred mouse strains display progression to lymphoma development after infection with E-55+ murine leukemia virus (E-55+ MuLV), while others demonstrate long-term nonprogression. This difference in disease progression occurs despite the fact that E-55+ MuLV causes persistent infection in both immunocompetent BALB/c–H-2k (BALB.K) progressor (P) and C57BL/10–H-2k (B10.BR) long-term nonprogressor (LTNP) mice. In contrast to immunocompetent mice, immunosuppressed mice from both P and LTNP strains develop lymphomas about 2 months after infection, indicating that the LTNP phenotype

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5

Pushker, Ravindra, Jean-Marc Jacqué, and Denis C. Shields. "Meta-Analysis To Test the Association of HIV-1 nef Amino Acid Differences and Deletions with Disease Progression." Journal of Virology 84, no. 7 (2010): 3644–53. http://dx.doi.org/10.1128/jvi.01959-09.

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ABSTRACT Previous relatively small studies have associated particular amino acid replacements and deletions in the HIV-1 nef gene with differences in the rate of HIV disease progression. We tested more rigorously whether particular nef amino acid differences and deletions are associated with HIV disease progression. Amino acid replacements and deletions in patients' consensus sequences were investigated for 153 progressor (P), 615 long-term nonprogressor (LTNP), and 2,311 unknown progressor sequences from 582 subtype B HIV-infected patients. LTNPs had more defective nefs (interrupted by frames

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Broström, Christina, Anders Sönnerborg, Stefan Lindbäck, and Hans Gaines. "Low Relative Frequencies of CD26+CD4+ Cells in Long-Term Nonprogressing Human Immunodeficiency Virus Type 1-Infected Subjects." Clinical Diagnostic Laboratory Immunology 5, no. 5 (1998): 662–66. http://dx.doi.org/10.1128/cdli.5.5.662-666.1998.

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ABSTRACT A broad antibody panel was used for immunophenotyping of human immunodeficiency virus type 1 (HIV-1)-infected patients who were long-term nonprogressors (LTNP). The LTNP were compared with patients in the early phase of infection and patients who had progressed to advanced immunodeficiency. Changes in CD8+ subset distribution were observed mainly at acquisition of HIV-1 infection, whereas CD4+ subset changes appeared during progression of HIV-1 infection. The decreasing levels of CD4+ cells were characterized by an increasing frequency of cells expressing the activation markers HLA-Dr

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Ogundeyi, MM, OO Oba-Daini, UP Adeniyi, and BI Adenuga. "A case report A Nigerian adolescent with Long term Non-progressive HIV-infection: A case report." Annals of Health Research 6, no. 2 (2020): 239–45. http://dx.doi.org/10.30442/ahr.0602-13-86.

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Children infected with the Human Immunodeficiency Virus (HIV) can be rapid progressors or be at the end of the spectrum of the illness as Long-term Non-progressors (LTNPs). Long term non-progressors are patients who never received Highly Active Anti-Retroviral Therapy (HAART) during the first decade of life and are maintaining good CD4+ count associated with declining HIV RNA values. The literature on paediatric patients with LTNP infection is sparse. An adolescent with HIV LTNP and likely vertical transmission of HIV is presented in this report. She presented with chronic cough, severe

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8

Crotti, Andrea, Francesca Neri, Davide Corti, et al. "Nef Alleles from Human Immunodeficiency Virus Type 1-InfectedLong-Term-Nonprogressor Hemophiliacs with or without Late Disease Progression Are Defective in Enhancing Virus Replication and CD4 Down-Regulation." Journal of Virology 80, no. 21 (2006): 10663–74. http://dx.doi.org/10.1128/jvi.02621-05.

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ABSTRACT Infection with human immunodeficiency virus (HIV)-encoding defective nef variants may contribute to a relatively benign course of disease in a minority of long-term nonprogressors (LTNP). We have examined the functions of nef alleles from six individuals belonging to the same cohort of hemophiliacs infected with HIV-1 prior to 1985 and classified as LTNP in 1995. Three out of six individuals have progressed to HIV disease (late progressors [LP]), whereas the three remainders have maintained their LTNP status at least up to 2003. The nef alleles were obtained from both plasma virus and

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9

Gaardbo, Julie C., Hans J. Hartling, Jan Gerstoft, and Susanne D. Nielsen. "Thirty Years with HIV Infection—Nonprogression Is Still Puzzling: Lessons to Be Learned from Controllers and Long-Term Nonprogressors." AIDS Research and Treatment 2012 (2012): 1–14. http://dx.doi.org/10.1155/2012/161584.

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In the early days of the HIV epidemic, it was observed that a minority of the infected patients did not progress to AIDS or death and maintained stable CD4+ cell counts. As the technique for measuring viral load became available it was evident that some of these nonprogressors in addition to preserved CD4+ cell counts had very low or even undetectable viral replication. They were therefore termed controllers, while those with viral replication were termed long-term nonprogressors (LTNPs). Genetics and virology play a role in nonprogression, but does not provide a full explanation. Therefore, h

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Lefrère, Jean-Jacques, Laurence Morand-Joubert, Martine Mariotti, et al. "Even Individuals Considered as Long-Term Nonprogressors Show Biological Signs of Progression After 10 Years of Human Immunodeficiency Virus Infection." Blood 90, no. 3 (1997): 1133–40. http://dx.doi.org/10.1182/blood.v90.3.1133.

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Abstract Despite a decade of human immunodeficiency virus (HIV) seropositivity, a few individuals termed as long-term nonprogressors (LTNPs) maintain a stable CD4+ T-cell count for a period of time. The aim of this study was to establish, through the sequential determination of all known predictors of HIV disease, the proportion of such patients having stringent criteria of true long-term nonprogression. Among 249 individuals who were HIV-infected and prospectively followed up over a 10-year period (1985 to 1995), 12 having a CD4+ T-cell count greater than 500/μL (LTNP I group) and 9 having a

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Lefrère, Jean-Jacques, Laurence Morand-Joubert, Martine Mariotti, et al. "Even Individuals Considered as Long-Term Nonprogressors Show Biological Signs of Progression After 10 Years of Human Immunodeficiency Virus Infection." Blood 90, no. 3 (1997): 1133–40. http://dx.doi.org/10.1182/blood.v90.3.1133.1133_1133_1140.

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Despite a decade of human immunodeficiency virus (HIV) seropositivity, a few individuals termed as long-term nonprogressors (LTNPs) maintain a stable CD4+ T-cell count for a period of time. The aim of this study was to establish, through the sequential determination of all known predictors of HIV disease, the proportion of such patients having stringent criteria of true long-term nonprogression. Among 249 individuals who were HIV-infected and prospectively followed up over a 10-year period (1985 to 1995), 12 having a CD4+ T-cell count greater than 500/μL (LTNP I group) and 9 having a CD4+ T-ce

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12

Muttineni. "Antiviral Potency of HIV Long term Survivors Sera." American Journal of Science and Medical Research 8, no. 2 (2022): 12–15. https://doi.org/10.5281/zenodo.7340286.

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<strong>ABSTRACT</strong> The survival of a small fraction (5-15%) of individuals without immunologic deterioration after being infected with HIV for more than 8-10 years without any therapy is still elusive. Long-term non-progressors of HIV -1 infected children serve as ideal models to study virological, genetic and immunological characteristics to determine factors associated with slow progression of disease and death due to their natural control of HIV-1 infection. LTNP and LTPs whole blood were collected by venipuncture in CPT tubes. Blood was transported to the lab within 3- 6 hours in a

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13

Jagannathan, Prasanna, Christine M. Osborne, Cassandra Royce, et al. "Comparisons of CD8+ T Cells Specific for Human Immunodeficiency Virus, Hepatitis C Virus, and Cytomegalovirus Reveal Differences in Frequency, Immunodominance, Phenotype, and Interleukin-2 Responsiveness." Journal of Virology 83, no. 6 (2009): 2728–42. http://dx.doi.org/10.1128/jvi.02128-08.

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ABSTRACT To better understand the components of an effective immune response to human immunodeficiency virus (HIV), the CD8+ T-cell responses to HIV, hepatitis C virus (HCV), and cytomegalovirus (CMV) were compared with regard to frequency, immunodominance, phenotype, and interleukin-2 (IL-2) responsiveness. Responses were examined in rare patients exhibiting durable immune-mediated control over HIV, termed long-term nonprogressors (LTNP) or elite controllers, and patients with progressive HIV infection (progressors). The magnitude of the virus-specific CD8+ T-cell response targeting HIV, CMV,

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Ciccosanti, Fabiola, Marco Corazzari, Rita Casetti та ін. "High Levels of TRIM5α Are Associated with Xenophagy in HIV-1-Infected Long-Term Nonprogressors". Cells 10, № 5 (2021): 1207. http://dx.doi.org/10.3390/cells10051207.

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Autophagy is a lysosomal-dependent degradative mechanism essential in maintaining cellular homeostasis, but it is also considered an ancient form of innate eukaryotic fighting against invading microorganisms. Mounting evidence has shown that HIV-1 is a critical target of autophagy that plays a role in HIV-1 replication and disease progression. In a special subset of HIV-1-infected patients that spontaneously and durably maintain extremely low viral replication, namely, long-term nonprogressors (LTNP), the resistance to HIV-1-induced pathogenesis is accompanied, in vivo, by a significant increa

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15

Tasca, Karen Ingrid, Camila Renata Correa, Juliana Trindade Caleffi, et al. "Asymptomatic HIV People Present Different Profiles of sCD14, sRAGE, DNA Damage, and Vitamins, according to the Use of cART and CD4+ T Cell Restoration." Journal of Immunology Research 2018 (2018): 1–11. http://dx.doi.org/10.1155/2018/7531718.

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We aimed to analyze markers of immune activation, inflammation, and oxidative stress in 92 asymptomatic HIV-infected patients according to the adequate (AR, >500 cells/mm3) or inadequate (IR, <500 cells/mm3) CD4+ T recovery and the presence or absence of antiretroviral treatment (cART). In relation to those newly diagnosed, they were divided into two groups, cART-naïve IR (nIR) and cART-naïve AR (nAR). Among those diagnosed more than five years ago, the following division was made: the cART-naïve long-term nonprogressors (LTNP); patient under cART and AR (tAR); and patients under cART an

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Huang, Lei, Jianning Deng, Ren Lang, Guoyang Liao, and Wei Jiang. "Enriched LPS Staining within the Germinal Center of a Lymph Node from an HIV-Infected Long-Term Nonprogressor but Not from Progressors." Journal of Immunology Research 2020 (May 6, 2020): 1–5. http://dx.doi.org/10.1155/2020/7471380.

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An increased level of microbial translocation has been observed in HIV-infected individuals. The host response to microbial translocation is compromised in HIV-infected progressors but remains unknown in HIV-infected long-term nonprogressors (LTNPs). To evaluate microbial translocation in HIV, we assessed lipopolysaccharide (LPS) immunohistochemistry staining in lymph nodes. We found enriched bacterial LPS immunohistochemistry staining in the germinal center of a lymph node from an HIV-infected LTNP, evenly distributed from three progressors with impaired germinal center structures and rarely

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17

van Pul, Lisa, Melissa Stunnenberg, Stefanie Kroeze, et al. "Energy demanding RNA and protein metabolism drive dysfunctionality of HIV-specific T cell changes during chronic HIV infection." PLOS ONE 19, no. 10 (2024): e0298472. http://dx.doi.org/10.1371/journal.pone.0298472.

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Antiretroviral treatment of HIV infected individuals cannot eliminate the HIV reservoir and immune control of HIV is rarely seen upon treatment interruption. In long-term non-progressors (LTNP), an effective CD8 T cell response is thought to contribute to be immune control of HIV. Here we studied the transcriptional profile of virus specific CD8 T cells during the asymptomatic phase of disease, to gain molecular insights in CD8 T cell functionality in HIV progressors and different groups of LTNP: HLA-B*57 LTNP, non-HLA-B*57 LTNP and individuals carrying the MAVS minor genotype (rs7262903/rs726

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Hadi, Kevin, Leah A. Walker, Debjani Guha, et al. "Human immunodeficiency virus type 1 Vpr polymorphisms associated with progressor and nonprogressor individuals alter Vpr-associated functions." Journal of General Virology 95, no. 3 (2014): 700–711. http://dx.doi.org/10.1099/vir.0.059576-0.

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Following infection with Human immunodeficiency virus 1 (HIV-1) there is a remarkable variation in virus replication and disease progression. Both host and viral factors have been implicated in the observed differences in disease status. Here, we focus on understanding the contribution of HIV-1 viral protein R (Vpr) by evaluating the disease-associated Vpr polymorphism and its biological functions from HIV-1 positive rapid progressor (RP) and long-term nonprogressor (LTNP) subjects. Results presented here show distinct variation in phenotypes of Vpr alleles from LTNP and RP subjects. Most nota

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Rimawi, B. H., R. H. Rimawi, M. Micallef, L. Pinckney, S. L. Fowler, and T. C. Dixon. "Pediatric HIV Long-Term Nonprogressors." Case Reports in Infectious Diseases 2014 (2014): 1–3. http://dx.doi.org/10.1155/2014/752312.

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Patients infected with HIV are best categorized along a continuum from rapid progressors to HIV long-term nonprogressors. Long-term nonprogressors (LTNPs) are those in which AIDS develop many years after being infected with HIV, often beyond the 10-year mark, and represent 15–20% of the HIV infected patients. Many of these patients are able to control their infection and maintain undetectable viral loads for long periods of time without antiretroviral therapy. After a comprehensive literature search, we found extensive data related to HIV LTNPs in the adult population; however, very limited da

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Choudhary, Shailesh K., Neelima R. Choudhary, Katherine C. Kimbrell, et al. "R5 Human Immunodeficiency Virus Type 1 Infection of Fetal Thymic Organ Culture Induces Cytokine and CCR5 Expression." Journal of Virology 79, no. 1 (2005): 458–71. http://dx.doi.org/10.1128/jvi.79.1.458-471.2005.

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ABSTRACT Late-stage CCR5 tropic human immunodeficiency virus type 1 (HIV-1) isolates (R5 HIV-1) can deplete nearly all CD4+ thymocytes from human thymus/liver grafts, despite the fact that fewer than 5% of these cells express CCR5. To resolve this paradox, we studied the replication and cytopathic effects (CPE) of late-stage R5 HIV-1 biological clones from two progressors and two long-term nonprogressors (LTNP) in fetal thymic organ culture (FTOC) with and without added cytokines. We found that R5 HIV-1 clones from progressors but not LTNP were cytopathic in untreated FTOC. Moreover, R5 HIV-1

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Migueles, Stephen A., Kristin A. Weeks, Eric Nou, et al. "Defective Human Immunodeficiency Virus-Specific CD8+ T-Cell Polyfunctionality, Proliferation, and Cytotoxicity Are Not Restored by Antiretroviral Therapy." Journal of Virology 83, no. 22 (2009): 11876–89. http://dx.doi.org/10.1128/jvi.01153-09.

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ABSTRACT Identifying the functions of human immunodeficiency virus (HIV)-specific CD8+ T cells that are not merely modulated by the level of virus but clearly distinguish patients with immune control from those without such control is of paramount importance. Features of the HIV-specific CD8+ T-cell response in antiretroviral-treated patients (designated Rx <50) and untreated patients (long-term nonprogressors [LTNP]) matched for very low HIV RNA levels were comprehensively examined. The proliferative capacity of HIV-specific CD8+ T cells was not restored in Rx <50 to the level observed

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Solis-Leal, Antonio, Dalton C. Karlinsey, Sidney T. Sithole, et al. "The HIV-1 vpr R77Q Mutant Induces Apoptosis, G2 Cell Cycle Arrest, and Lower Production of Pro-Inflammatory Cytokines in Human CD4+ T Cells." Viruses 16, no. 10 (2024): 1642. http://dx.doi.org/10.3390/v16101642.

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Acquired immunodeficiency syndrome (AIDS) occurs when HIV depletes CD4+ helper T cells. Some patients develop AIDS slowly or not at all, and are termed long-term non-progressors (LTNP), and while mutations in the HIV-1 Viral Protein R (vpr) gene such as R77Q are associated with LTNP, mechanisms for this correlation are unclear. This study examines the induction of apoptosis, cell cycle arrest, and pro-inflammatory cytokine release in the HUT78 T cell line following infection with replication-competent wild-type strain NL4-3, the R77Q mutant, or a vpr Null mutant. Our results show a significant

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Laurén, Anna, Rigmor Thorstensson, and Eva Maria Fenyö. "Comparative studies on mucosal and intravenous transmission of simian immunodeficiency virus (SIVsm): the kinetics of evolution to neutralization resistance are related to progression rate of disease." Journal of General Virology 87, no. 3 (2006): 595–606. http://dx.doi.org/10.1099/vir.0.81409-0.

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The kinetics of appearance of autologous neutralizing antibodies were studied in cynomolgus macaques infected with simian immunodeficiency virus (SIVsm) by the intravenous (IV) route (six monkeys) or the intrarectal (IR) route (ten monkeys). The SIVsm inoculum virus and reisolates obtained at 2 weeks, 3 or 4 months and later than 1 year were tested in a GHOST(3) cell line-based plaque-reduction assay with autologous sera collected at the same sampling times. All monkeys developed a neutralizing-antibody response to the inoculum virus, those infected by the IV route earlier than monkeys infecte

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Ling, Binhua, Stefanie Perez, Ann-Marie Johnson, and lara Doyle-Meyers. "Immune restoration, activation and viral reservoirs in gut-associated lymphoid tissue in SIV-infected long-term nonprogressing Chinese rhesus macaques on antiretroviral therapy (VIR1P.1130)." Journal of Immunology 194, no. 1_Supplement (2015): 74.7. http://dx.doi.org/10.4049/jimmunol.194.supp.74.7.

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Abstract HIV infected long-term nonprogressors (LTNPs) and elite controllers (ECs) maintain enduring control of HIV infection without antiretroviral therapy. However, persistent tissue reservoirs and chronic inflammation still exist. We previously found that 1/3 of SIV-infected Chinese rhesus macaques mimics HIV-infected LTNPs/ECs. Here we studied whether therapy can further decrease tissue reservoirs, restore immune function and decrease inflammation in this model. Six LTNPs/ECs and 4 progressors were treated with PMPA and FTC daily for up to 24 weeks during chronic infection. Blood, lymph no

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Keckler, M. Shannon, Vida L. Hodara, Laura M. Parodi, and Luis D. Giavedoni. "Maintenance or Emergence of Chronic Phase Secondary Cytotoxic T Lymphocyte Responses after Loss of Acute Phase Immunodominant Responses Does Not Protect SIV-Infected Rhesus Macaques from Disease Progression." Journal of Biomedicine and Biotechnology 2010 (2010): 1–9. http://dx.doi.org/10.1155/2010/279391.

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The simian immunodeficiency virus- (SIV-) infected rhesus macaque is the preferred animal model for vaccine development, but the correlates of protection in this model are not completely understood. In this paper, we document the cytotoxic T lymphocyte (CTL) response to SIV and its effects on viral evolution in an effort to identify events associated with disease progression regardless of MHC allele expression. We observed the evolution of epitopes targeted by CTLs in a group of macaques that included long-term nonprogressing (LTNP), slowly progressing (SP), normally progressing (NP), and rapi

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Scala, E., G. D'Offizi, R. Rosso, et al. "C-C chemokines, IL-16, and soluble antiviral factor activity are increased in cloned T cells from subjects with long-term nonprogressive HIV infection." Journal of Immunology 158, no. 9 (1997): 4485–92. http://dx.doi.org/10.4049/jimmunol.158.9.4485.

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Abstract A combination of three beta, or C-C, chemokines, as well as IL-16, have been shown to inhibit HIV replication in vitro. Cellular antiviral factor is a more potent agent, and acts on all HIV strains. All are mainly, but not exclusively, produced by CD8+ T cells, both in HIV+ and healthy subjects. We studied the production of these HIV-suppressive factors in patients with HIV infection at different stages of disease. No difference in production by PBMC stimulated with PHA has been observed in asymptomatic HIV+, long-term nonprogressors (LTnP), and AIDS patients. When T cell line superna

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Cabrera-Rodríguez, Romina, Silvia Pérez-Yanes, Rafaela Montelongo, et al. "Transactive Response DNA-Binding Protein (TARDBP/TDP-43) Regulates Cell Permissivity to HIV-1 Infection by Acting on HDAC6." International Journal of Molecular Sciences 23, no. 11 (2022): 6180. http://dx.doi.org/10.3390/ijms23116180.

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The transactive response DNA-binding protein (TARDBP/TDP-43) influences the processing of diverse transcripts, including that of histone deacetylase 6 (HDAC6). Here, we assessed TDP-43 activity in terms of regulating CD4+ T-cell permissivity to HIV-1 infection. We observed that overexpression of wt-TDP-43 increased both mRNA and protein levels of HDAC6, resulting in impaired HIV-1 infection independently of the viral envelope glycoprotein complex (Env) tropism. Consistently, using an HIV-1 Env-mediated cell-to-cell fusion model, the overexpression of TDP-43 levels negatively affected viral Env

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Ushkov, Valentin, Ruslan Ibragimov, Oleg Figovsky, and Svetlana Samchenko. "REPAIR MORTARS OBTAINED BY PLASMA MODIFICATION AND VORTEX ACTIVATION." Architecture and Engineering 7, no. 4 (2022): 60–69. http://dx.doi.org/10.23968/2500-0055-2022-7-4-60-69.

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Introduction: The service life of reinforced-concrete structures can be increased with the use of effective repair compositions obtained by activating the original components. Purpose of the study: We aimed to develop effective repair compounds obtained by activating the original components. Methods: To process the original components, low-temperature non-equilibrium plasma (LTNP) and electromagnetic activation in a vortex layer device were used. In the course of the study, we used polypropylene, steel, glass, and basalt fiber and fiber made of structured ferromagnetic microwire. Electron micr

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van Gils, Marit J., Evelien M. Bunnik, Judith A. Burger, et al. "Rapid Escape from Preserved Cross-Reactive Neutralizing Humoral Immunity without Loss of Viral Fitness in HIV-1-Infected Progressors and Long-Term Nonprogressors." Journal of Virology 84, no. 7 (2010): 3576–85. http://dx.doi.org/10.1128/jvi.02622-09.

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ABSTRACT A substantial proportion of human immunodeficiency virus type 1 (HIV-1)-infected individuals has cross-reactive neutralizing activity in serum, with a similar prevalence in progressors and long-term nonprogressors (LTNP). We studied whether disease progression in the face of cross-reactive neutralizing serum activity is due to fading neutralizing humoral immunity over time or to viral escape. In three LTNP and three progressors, high-titer cross-reactive HIV-1-specific neutralizing activity in serum against a multiclade pseudovirus panel was preserved during the entire clinical course

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Tolstrup, Martin, Alex L. Laursen, Jan Gerstoft, Finn S. Pedersen, Lars Ostergaard, and Mogens Duch. "Cysteine 138 mutation in HIV-1 Nef from patients with delayed disease progression." Sexual Health 3, no. 4 (2006): 281. http://dx.doi.org/10.1071/sh06002.

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Background: The nef gene from HIV-1 has been shown to be an important pathogenic factor when considering development of AIDS. Detection of nef variants with an effect on immune modulation is important to understand HIV-1 pathogenesis and has possible impact on treatment strategies. Methods: The nef gene of HIV-1 isolates from patients in a long-term non-progressor (LTNP) cohort and a slow-progressor (SP) cohort (n = 11) was analysed and compared with isolates from a control patient group of progressors (n = 18). Most of the patients with delayed disease progression had extensive medical record

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Tilton, John C., Marlise R. Luskin, Alison J. Johnson, et al. "Changes in Paracrine Interleukin-2 Requirement, CCR7 Expression, Frequency, and Cytokine Secretion of Human Immunodeficiency Virus-Specific CD4+ T Cells Are a Consequence of Antigen Load." Journal of Virology 81, no. 6 (2006): 2713–25. http://dx.doi.org/10.1128/jvi.01830-06.

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ABSTRACT Virus-specific CD4+ T-cell responses are thought to be required for the induction and maintenance of many effective CD8+ T-cell and B-cell immune responses in experimental animals and humans. Although the presence of human immunodeficiency virus (HIV)-specific CD4+ T cells has been documented in patients at all stages of HIV infection, many fundamental questions regarding their frequency and function remain. A 10-color, 12-parameter flow cytometric panel was utilized to examine the frequency, memory phenotype (CD27, CCR7, and CD45RA), and cytokine production (interleukin-2 [IL-2], gam

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Williams, R. Michael, Joaquin Zuniga, Julio Granados, and Edmond J. Yunis. "Role of natural killer cell activity in HIV infections, aging, and breast cancer survival." Journal of Immunology 202, no. 1_Supplement (2019): 120.5. http://dx.doi.org/10.4049/jimmunol.202.supp.120.5.

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Abstract Natural killer cell activity participates in the elimination of tumors and virus infections. Data presented here include their role in a virus infection (HIV), metastatic breast cancer, and aging per se. We have analyzed two gene segments MHC HLA class I ligands and NK receptors Each have single amino acid differences. Together these alleles can identify long term survivors. Homozygosity of HLA–Bw4 supertype in HIV progression has been described. Since HLA-KIR genetic interactions of HLA-Bw4 with KIR (3DS1) only included Bw4, with the exception of B*27 and B*44 that use different mech

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Pernas, Maria, Victor Sanchez-Merino, Concepcion Casado, et al. "HIV-1 Dual Infected LTNP-EC Patients Developed an Unexpected Antibody Cross-Neutralizing Activity." PLOS ONE 10, no. 8 (2015): e0134054. http://dx.doi.org/10.1371/journal.pone.0134054.

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Maciel, Marcel Gonçalves, Francielle de Luna Souto, Joyce Michele Souza De Souza, Luiz Henrique Gonçalves Maciel, Oberdan Henrique Moreira Tavares, and Michael Nosano Yakubu. "LONG-TERM NON-PROGRESSOR (LTNP) HIV INFECTION. A CASE REPORT OF AN 81-YEAR-OLD WOMAN." Arquivos de Ciências da Saúde da UNIPAR 27, no. 3 (2023): 1123–28. http://dx.doi.org/10.25110/arqsaude.v27i3.2023-005.

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An 81-year-old woman, long-term non-progressor HIV infected, asymptomatic, not using ART, with a seven-year clinical follow-up in a reference unit, TCD4+ cell count values ranged from 719 to 1151 cells/µl, TCD8+ from 579 to 897 cells/µl and a viral load with higher value of 51 viral copies/ml but with undetectable results in most of the tests performed. The report of the long-term non-progressor HIV carrier aged over 80 years is somewhat unusual, considering the physiological/immunological changes that occur with the aging process concomitantly with HIV infection.

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Antoni, Sascha, Nicole Walz, Margot Landersz, et al. "Genetic and Biological Characterization of Recombinant HIV Type 1 with Env Derived from Long-Term Nonprogressor (LTNP) Viruses." AIDS Research and Human Retroviruses 23, no. 11 (2007): 1377–86. http://dx.doi.org/10.1089/aid.2007.0113.

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Baron, Sarah, Meghan Garrett, and Mark D. Hicar. "1008. Presence of Antibody Dependent Cell Cytotoxicity (ADCC) Functional Antibodies that Target a Complex Gp41 Epitope Correlates with Long-term Non-progression and ADCC is Maintained with Mutants Using Germline Heavy Chain Variable Gene Sequence of VH1-02 Gene." Open Forum Infectious Diseases 8, Supplement_1 (2021): S594—S595. http://dx.doi.org/10.1093/ofid/ofab466.1202.

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Abstract Background Recent data supports that improved qualitative antibody responses correlate with elite controllers (EC) of HIV. As ADCC has been associated with protection in vaccine studies, thorough exploration of antibodies that facilitate ADCC is warranted. In studies on monoclonal antibodies from long-term non-progressors (LTNPs), our laboratory has previously described highly mutated antibodies against a complex conformational epitope with contributions from both gp41 heptad repeat regions. Despite using the VH1-02 gene segment, known to contribute to some of the broadest neutralizin

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Narayanan, Vaasudev, and Bhargav Parsi. "Center Symmetric Local Descriptors for Image Classification." International Journal of Natural Computing Research 7, no. 4 (2018): 56–70. http://dx.doi.org/10.4018/ijncr.2018100104.

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Local feature description forms an integral part of texture classification, image recognition, and face recognition. In this paper, the authors propose Center Symmetric Local Ternary Mapped Patterns (CS-LTMP) and eXtended Center Symmetric Local Ternary Mapped Patterns (XCS-LTMP) for local description of images. They combine the strengths of Center Symmetric Local Ternary Pattern (CS-LTP) which uses ternary codes and Center Symmetric Local Mapped Pattern (CS-LMP) which captures the nuances between images to make the CS-LTMP. Similarly, the auhtors combined CS-LTP and eXtended Center Symmetric L

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Corder, Elizabeth, Luciano Galeazzi, Claudio Franceschi, et al. "Differential course of HIV-1 infection and apolipoprotein E polymorphism." Open Medicine 2, no. 4 (2007): 404–16. http://dx.doi.org/10.2478/s11536-007-0039-x.

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AbstractWe studied the course of infection with human immunodeficiency virus type 1 (HIV-1) in relation to apolipoprotein E (APOE) polymorphism found for 209 Italians treated at Infectious Disease Clinics in Rome and Modena. Clinically, patients were classified into four groups according to the yearly rate of decline in CD4+ cell count (LTNP: long-term non-progression; SLOW, ’NORMAL’ or RAPID). Patients at both extremes of the clinical spectrum, i.e. those who rapidly progressed to AIDS and those with stable high CD4 cell counts, had few APOE ɛ4 and ɛ2 alleles (P = 0.04). Detailed clinical inf

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OLOFSSON, Anders, Ulf HELLMAN, Peter TEN DIJKE та ін. "Latent transforming growth factor-β complex in Chinese hamster ovary cells contains the multifunctional cysteine-rich fibroblast growth factor receptor, also termed E-selectin-ligand or MG-160". Biochemical Journal 324, № 2 (1997): 427–34. http://dx.doi.org/10.1042/bj3240427.

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Transforming growth factor-β (TGF-β) is secreted as latent high molecular mass complexes from producer cells. The N-terminal precursor remnant, also called latency-associated peptide (LAP), forms a non-covalently linked complex with TGF-β and confers the latency to TGF-β. In human platelets and certain other cell types, latent TGF-β binding protein-1 (LTBP-1) is disulphide-linked to LAP, and forms complexes of more than 230 kDa. In addition, LTBP-2 and -3, which are structurally similar to LTBP-1, can be part of latent TGF-β complexes. In Chinese hamster ovary (CHO) cells transfected with the

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Pernas, María, Concepción Casado, Carolina Arcones, et al. "Low-Replicating Viruses and Strong Anti-Viral Immune Response Associated with Prolonged Disease Control in a Superinfected HIV-1 LTNP Elite Controller." PLoS ONE 7, no. 2 (2012): e31928. http://dx.doi.org/10.1371/journal.pone.0031928.

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Ahmad, Ali, Suzanne Samarani, Ayoub Abulkhir, and Devendra Amre. "Regulation of IL-37 and its signaling co-receptor IL-1R8 in HIV infection." Journal of Immunology 202, no. 1_Supplement (2019): 75.14. http://dx.doi.org/10.4049/jimmunol.202.supp.75.14.

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Abstract IL-37 is a member of the IL-1 family with potent anti-inflammatory and immune deviating effects. The cytokine exerts its biological effects via IL-1R8 (also formerly known as TIR-8 and SIGIRR), the signaling component of its receptor. Little is known about the regulation of the cytokine and of its receptor in HIV infection. The objective of this study was to investigate how the production of the cytokine and the expression of the signalling component of its receptor on immune cells was regulated in HIV infection. The study was conducted using biological samples from a cross section of

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Kang, Seok, Ha-Mok Jeong, Beom-Suk Kim, and Joon-Shik Yoon. "Risk Analysis of Needle Injury to the Long Thoracic Nerve during Ultrasound-Guided C7 Selective Nerve Root Block." Medicina 57, no. 6 (2021): 635. http://dx.doi.org/10.3390/medicina57060635.

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Background and Objectives: Ultrasound (US)-guided cervical selective nerve root block (SNRB) is a widely used treatment for upper limb radicular pain. The long thoracic nerve (LTN) passes through the middle scalene muscle (MSM) at the C7 level. The needle trajectory of US-guided C7 SNRB pierces the MSM, therefore indicating a high probability of injury to the LTN. We aimed to identify the LTN and to investigate the risk of needle injury to the nerve during US-guided C7 SNRB. Materials and Methods: This retrospective observational study included 30 patients who underwent US-guided SNRB at the C

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Farina, Iole, Mauro Andreotti, Claudia Pastori, et al. "Modulation of CCR5 expression and R5 HIV-1 infection in primary macrophages exposed to sera from HESN, LTNP, and chronically HIV-1 infected people with or without natural antibodies to CCR5." Virus Research 350 (December 2024): 199506. https://doi.org/10.1016/j.virusres.2024.199506.

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Kalyadin, Anton Yu, Grigor V. Nalbandyan, Vadim G. Soloviev, Anfisa A. Bogdanova, and Valentin A. Ushkov. "Plasma modification of construction mortar components, an efficient method of increasing their performance." Vestnik MGSU, no. 5 (May 2019): 548–58. http://dx.doi.org/10.22227/1997-0935.2019.5.548-558.

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Introduction. The article considers the enhancement of physical and mechanical parameters of construction mortars used for recovering and repairing of building structures of communication collectors by using low-temperature nonequilibrium plasma. The study vindicated the expediency of treatment of construction mortar raw materials with LTNP to enhance their physical and mechanical parameters. The effect of plasma modification of raw materials on Portland cement phase composition, granulometric composition of the sand and mortar properties are analysed. The influence of multiplicity of silica s

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Gozlan, H., R. Khazipov, D. Diabira, and Y. Ben-Ari. "In CA1 hippocampal neurons, the redox state of NMDA receptors determines LTP expressed by NMDA but not by AMPA receptors." Journal of Neurophysiology 73, no. 6 (1995): 2612–17. http://dx.doi.org/10.1152/jn.1995.73.6.2612.

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1. Using extracellular recording techniques in the CA1 region of the rat hippocampus, we have evaluated the effects of the redox reagents 5,5O-dithiobis-2-nitrobenzoic acid (DTNB) and tris (carboxyethyl) phosphine (TCEP) on long-term potentiation (LTP) expressed by alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid (AMPA) and N-methyl-D-aspartate (NMDA) receptors. In physiological conditions a high-frequency stimulation (HFS) of Schaffer collateral-commissural fibers induced a LTP expressed by a persistent increase (73 +/- 13%, mean +/- SE, n = 8/10) of AMPA field potentials (LTPA). In

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Hassan, H. F., A. S. Al-Nuaimi, R. Taha, and T. M. A. Jafar. "Development of Asphalt Pavement Temperature Models for Oman." Journal of Engineering Research [TJER] 2, no. 1 (2005): 32. http://dx.doi.org/10.24200/tjer.vol2iss1pp32-42.

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Asphalt pavements form an integral part of any transportation system. The structural capacity of the hot mix asphalt concrete layers depends on many factors including its temperature. Moreover, temperature can be a major contributor to several types of distresses. Therefore, temperature is a significant factor that affects the performance and life span of a pavement. The Sultanate of Oman's road network expanded at a phenomenal pace from approximately 10 km of paved roads in 1970 to 9,673 km in 2001. with the recent SHRP and LTTP research findings, it was necessary to investigate the applicabi

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Bhandarkar, Sumitha, Saurabh Jain, and A. L. Narasimha Reddy. "LTCP." ACM SIGCOMM Computer Communication Review 36, no. 1 (2006): 41–50. http://dx.doi.org/10.1145/1111322.1111332.

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Peng, ChengZhi, ShiYu Yao, WenJuan Huang, et al. "Climate: The dominant factor influencing the spatial distribution pattern of the leaf trait network of Populus euphratica along the main stream of the Tarim River." PLOS One 20, no. 5 (2025): e0323305. https://doi.org/10.1371/journal.pone.0323305.

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Leaves are the primary interface through which plants interact with the environment, their functional traits (morphology, anatomy, physiology) directly reflecting ecological strategies that mediate species-environment interactions. These traits link plant performance to ecosystem processes, shaping species distributions and coexistence via their complex relationships with climatic and edaphic factors. Based on previous work, we selected 20 P. euphratica trees along the desert riparian forest of the main stream of the Tarim River for leaf sample collection and habitat survey. We used 27 leaf tr

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Nunes, Irene, Pierre-Emmanuel Gleizes, Christine N. Metz та Daniel B. Rifkin. "Latent Transforming Growth Factor-β Binding Protein Domains Involved in Activation and Transglutaminase-dependent Cross-Linking of Latent Transforming Growth Factor-β". Journal of Cell Biology 136, № 5 (1997): 1151–63. http://dx.doi.org/10.1083/jcb.136.5.1151.

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Transforming growth factor-β (TGF-β) is secreted by many cell types as part of a large latent complex composed of three subunits: TGF-β, the TGF-β propeptide, and the latent TGF-β binding protein (LTBP). To interact with its cell surface receptors, TGF-β must be released from the latent complex by disrupting noncovalent interactions between mature TGF-β and its propeptide. Previously, we identified LTBP-1 and transglutaminase, a cross-linking enzyme, as reactants involved in the formation of TGF-β. In this study, we demonstrate that LTBP-1 and large latent complex are substrates for transgluta

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Kumra, Heena, Valentin Nelea, Hana Hakami, et al. "Fibulin-4 exerts a dual role in LTBP-4L–mediated matrix assembly and function." Proceedings of the National Academy of Sciences 116, no. 41 (2019): 20428–37. http://dx.doi.org/10.1073/pnas.1901048116.

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Elastogenesis is a hierarchical process by which cells form functional elastic fibers, providing elasticity and the ability to regulate growth factor bioavailability in tissues, including blood vessels, lung, and skin. This process requires accessory proteins, including fibulin-4 and -5, and latent TGF binding protein (LTBP)-4. Our data demonstrate mechanisms in elastogenesis, focusing on the interaction and functional interdependence between fibulin-4 and LTBP-4L and its impact on matrix deposition and function. We show that LTBP-4L is not secreted in the expected extended structure based on

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