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Relevant bibliographies by topics / Ltnps

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Journal articles

Academic literature on the topic 'Ltnps'

Author: Grafiati

Published: 4 June 2021

Last updated: 5 February 2022

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Journal articles on the topic "Ltnps"

1

Rimawi, B. H., R. H. Rimawi, M. Micallef, L. Pinckney, S. L. Fowler, and T. C. Dixon. "Pediatric HIV Long-Term Nonprogressors." Case Reports in Infectious Diseases 2014 (2014): 1–3. http://dx.doi.org/10.1155/2014/752312.

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Patients infected with HIV are best categorized along a continuum from rapid progressors to HIV long-term nonprogressors. Long-term nonprogressors (LTNPs) are those in which AIDS develop many years after being infected with HIV, often beyond the 10-year mark, and represent 15–20% of the HIV infected patients. Many of these patients are able to control their infection and maintain undetectable viral loads for long periods of time without antiretroviral therapy. After a comprehensive literature search, we found extensive data related to HIV LTNPs in the adult population; however, very limited da

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2

Pushker, Ravindra, Jean-Marc Jacqué, and Denis C. Shields. "Meta-Analysis To Test the Association of HIV-1 nef Amino Acid Differences and Deletions with Disease Progression." Journal of Virology 84, no. 7 (2010): 3644–53. http://dx.doi.org/10.1128/jvi.01959-09.

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ABSTRACT Previous relatively small studies have associated particular amino acid replacements and deletions in the HIV-1 nef gene with differences in the rate of HIV disease progression. We tested more rigorously whether particular nef amino acid differences and deletions are associated with HIV disease progression. Amino acid replacements and deletions in patients' consensus sequences were investigated for 153 progressor (P), 615 long-term nonprogressor (LTNP), and 2,311 unknown progressor sequences from 582 subtype B HIV-infected patients. LTNPs had more defective nefs (interrupted by frames

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3

Huang, Lei, Jianning Deng, Ren Lang, Guoyang Liao, and Wei Jiang. "Enriched LPS Staining within the Germinal Center of a Lymph Node from an HIV-Infected Long-Term Nonprogressor but Not from Progressors." Journal of Immunology Research 2020 (May 6, 2020): 1–5. http://dx.doi.org/10.1155/2020/7471380.

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An increased level of microbial translocation has been observed in HIV-infected individuals. The host response to microbial translocation is compromised in HIV-infected progressors but remains unknown in HIV-infected long-term nonprogressors (LTNPs). To evaluate microbial translocation in HIV, we assessed lipopolysaccharide (LPS) immunohistochemistry staining in lymph nodes. We found enriched bacterial LPS immunohistochemistry staining in the germinal center of a lymph node from an HIV-infected LTNP, evenly distributed from three progressors with impaired germinal center structures and rarely

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4

Ogundeyi, MM, OO Oba-Daini, UP Adeniyi, and BI Adenuga. "A case report A Nigerian adolescent with Long term Non-progressive HIV-infection: A case report." Annals of Health Research 6, no. 2 (2020): 239–45. http://dx.doi.org/10.30442/ahr.0602-13-86.

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Children infected with the Human Immunodeficiency Virus (HIV) can be rapid progressors or be at the end of the spectrum of the illness as Long-term Non-progressors (LTNPs). Long term non-progressors are patients who never received Highly Active Anti-Retroviral Therapy (HAART) during the first decade of life and are maintaining good CD4+ count associated with declining HIV RNA values. The literature on paediatric patients with LTNP infection is sparse. An adolescent with HIV LTNP and likely vertical transmission of HIV is presented in this report. She presented with chronic cough, severe

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5

Mendoza, Daniel, Sarah A. Johnson, Bennett A. Peterson, et al. "Comprehensive analysis of unique cases with extraordinary control over HIV replication." Blood 119, no. 20 (2012): 4645–55. http://dx.doi.org/10.1182/blood-2011-10-381996.

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Abstract True long-term nonprogressors (LTNPs)/elite controllers (ECs) maintain durable control over HIV replication without antiretroviral therapy. Herein we describe 4 unique persons who were distinct from conventional LTNPs/ECs in that they had extraordinarily low HIV burdens and comparatively weak immune responses. As a group, typical LTNPs/ECs have unequivocally reactive HIV-1 Western blots, viral loads below the lower threshold of clinical assays, low levels of persistent viral reservoirs, an over-representation of protective HLA alleles, and robust HIV-specific CD8+ T-cell responses. Th

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6

Michel, Katherine Gisella, Bing Ma, Kathleen Weber, et al. "4117 UNIQUE VAGINAL MICROBIOME POPULATIONS AND MICROBIAL GENE CONTENT AMONG WOMEN WHO NATURALLY CONTROL HIV PROGRESSION." Journal of Clinical and Translational Science 4, s1 (2020): 20–21. http://dx.doi.org/10.1017/cts.2020.102.

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OBJECTIVES/GOALS: The role of the vaginal microbiome (VM) in HIV disease progression is poorly understood. We examined VMs of HIV+ Elite Controllers (ECs) and HIV+ Long-Term Non-Progressors (LTNPs) compared to controls: HIV-positive antiretroviral (ARV) treated (HIV+ATs) and HIV-negative women in the Women’s Interagency HIV Study (DC/Chicago/Atlanta sites). METHODS/STUDY POPULATION: VMs were surveyed via both V3/V4 region of 16S rRNA gene amplicon sequencing and metagenomics sequencing in 67 women across 4 study groups: 1) LTNPs (CD4 >500 cells/mL for 5+ years without ARVs) (n = 7) and 2) E

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7

Tobiume, Minoru, Mikako Takahoko, Takeshi Yamada, Masashi Tatsumi, Aikichi Iwamoto, and Michiyuki Matsuda. "Inefficient Enhancement of Viral Infectivity and CD4 Downregulation by Human Immunodeficiency Virus Type 1 Nef from Japanese Long-Term Nonprogressors." Journal of Virology 76, no. 12 (2002): 5959–65. http://dx.doi.org/10.1128/jvi.76.12.5959-5965.2002.

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ABSTRACT It has been reported that patients infected with nef-defective human immunodeficiency virus type 1 (HIV-1) do not progress to AIDS; however, mutations that abrogate Nef expression are not common in long-term nonprogressors (LTNPs). We postulated that Nef function might be impaired in LTNPs, irrespective of the presence or absence of detectable amino acid sequence anomalies. To challenge this hypothesis we compared in vitro function of nef alleles that were derived from three groups of Japanese patients: LTNPs, progressors, and asymptomatic carriers (ACs). The patient-derived nef allel

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8

Jiang, Yongjun, Xiaojian Cui, Chen Cui, et al. "The Function of CD3+CD56+NKT-Like Cells in HIV-Infected Individuals." BioMed Research International 2014 (2014): 1–9. http://dx.doi.org/10.1155/2014/863625.

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CD3+CD56+NKT-like cells are one of the critical effectors in the immune response to viral infection and tumors, but the functional features of NKT-like cells in HIV infection have been rarely reported. In this study, we observed and described the state of NKT-like cell functions in primary HIV-infected individuals (PHIs), chronic HIV-infected individuals (CHIs), long-term nonprogressors (LTNPs), and HIV-negative controls (NCs). The results showed that the percentage of IFN-γ+CD3+CD56+NKT-like cells was notably higher in LTNPs compared with CHIs, and the proportion of CD3+CD56+NKT-like cells wi

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9

Zhang, Ji-Yuan, Zheng Zhang, Xicheng Wang, et al. "PD-1 up-regulation is correlated with HIV-specific memory CD8+ T-cell exhaustion in typical progressors but not in long-term nonprogressors." Blood 109, no. 11 (2007): 4671–78. http://dx.doi.org/10.1182/blood-2006-09-044826.

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Abstract The immunoreceptor PD-1 is significantly up-regulated on exhausted CD8+ T cells during chronic viral infections such as HIV-1. However, it remains unknown whether PD-1 expression on CD8+ T cells differs between typical progressors (TPs) and long-term nonprogressors (LTNPs). In this report, we examined PD-1 expression on HIV-specific CD8+ T cells from 63 adults with chronic HIV infection. We found that LTNPs exhibited functional HIV-specific memory CD8+ T cells with markedly lower PD-1 expression. TPs, in contrast, showed significantly up-regulated PD-1 expression that was closely corr

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10

de Quiros, Juan Carlos Lopez Bernaldo, W. Lesley Shupert, Andrew C. McNeil, et al. "Resistance to Replication of Human Immunodeficiency Virus Challenge in SCID-Hu Mice Engrafted with Peripheral Blood Mononuclear Cells of Nonprogressors Is Mediated by CD8+T Cells and Associated with a Proliferative Response to p24 Antigen." Journal of Virology 74, no. 4 (2000): 2023–28. http://dx.doi.org/10.1128/jvi.74.4.2023-2028.2000.

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ABSTRACT High levels of resistance to challenge with human immunodeficiency virus type 1 SF162 were observed in animals engrafted with peripheral blood mononuclear cells of four long-term nonprogressors (LTNPs). Resistance was abrogated by depletion of CD8+ T cells in vivo and was observed only in LTNPs with proliferative responses to p24. In a subgroup of nonprogressors, CD8+ T cells mediated restriction of challenge viruses, and this response was associated with strong proliferative responses to p24 antigen.

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