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Journal articles on the topic 'Ltnps'

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Published: 4 June 2021
Last updated: 5 February 2022

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1

Rimawi, B. H., R. H. Rimawi, M. Micallef, L. Pinckney, S. L. Fowler, and T. C. Dixon. "Pediatric HIV Long-Term Nonprogressors." Case Reports in Infectious Diseases 2014 (2014): 1–3. http://dx.doi.org/10.1155/2014/752312.

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Patients infected with HIV are best categorized along a continuum from rapid progressors to HIV long-term nonprogressors. Long-term nonprogressors (LTNPs) are those in which AIDS develop many years after being infected with HIV, often beyond the 10-year mark, and represent 15–20% of the HIV infected patients. Many of these patients are able to control their infection and maintain undetectable viral loads for long periods of time without antiretroviral therapy. After a comprehensive literature search, we found extensive data related to HIV LTNPs in the adult population; however, very limited da
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2

Pushker, Ravindra, Jean-Marc Jacqué, and Denis C. Shields. "Meta-Analysis To Test the Association of HIV-1 nef Amino Acid Differences and Deletions with Disease Progression." Journal of Virology 84, no. 7 (2010): 3644–53. http://dx.doi.org/10.1128/jvi.01959-09.

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ABSTRACT Previous relatively small studies have associated particular amino acid replacements and deletions in the HIV-1 nef gene with differences in the rate of HIV disease progression. We tested more rigorously whether particular nef amino acid differences and deletions are associated with HIV disease progression. Amino acid replacements and deletions in patients' consensus sequences were investigated for 153 progressor (P), 615 long-term nonprogressor (LTNP), and 2,311 unknown progressor sequences from 582 subtype B HIV-infected patients. LTNPs had more defective nefs (interrupted by frames
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3

Huang, Lei, Jianning Deng, Ren Lang, Guoyang Liao, and Wei Jiang. "Enriched LPS Staining within the Germinal Center of a Lymph Node from an HIV-Infected Long-Term Nonprogressor but Not from Progressors." Journal of Immunology Research 2020 (May 6, 2020): 1–5. http://dx.doi.org/10.1155/2020/7471380.

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An increased level of microbial translocation has been observed in HIV-infected individuals. The host response to microbial translocation is compromised in HIV-infected progressors but remains unknown in HIV-infected long-term nonprogressors (LTNPs). To evaluate microbial translocation in HIV, we assessed lipopolysaccharide (LPS) immunohistochemistry staining in lymph nodes. We found enriched bacterial LPS immunohistochemistry staining in the germinal center of a lymph node from an HIV-infected LTNP, evenly distributed from three progressors with impaired germinal center structures and rarely
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4

Ogundeyi, MM, OO Oba-Daini, UP Adeniyi, and BI Adenuga. "A case report A Nigerian adolescent with Long term Non-progressive HIV-infection: A case report." Annals of Health Research 6, no. 2 (2020): 239–45. http://dx.doi.org/10.30442/ahr.0602-13-86.

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Children infected with the Human Immunodeficiency Virus (HIV) can be rapid progressors or be at the end of the spectrum of the illness as Long-term Non-progressors (LTNPs). Long term non-progressors are patients who never received Highly Active Anti-Retroviral Therapy (HAART) during the first decade of life and are maintaining good CD4+ count associated with declining HIV RNA values. The literature on paediatric patients with LTNP infection is sparse.
 An adolescent with HIV LTNP and likely vertical transmission of HIV is presented in this report. She presented with chronic cough, severe
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5

Mendoza, Daniel, Sarah A. Johnson, Bennett A. Peterson, et al. "Comprehensive analysis of unique cases with extraordinary control over HIV replication." Blood 119, no. 20 (2012): 4645–55. http://dx.doi.org/10.1182/blood-2011-10-381996.

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Abstract True long-term nonprogressors (LTNPs)/elite controllers (ECs) maintain durable control over HIV replication without antiretroviral therapy. Herein we describe 4 unique persons who were distinct from conventional LTNPs/ECs in that they had extraordinarily low HIV burdens and comparatively weak immune responses. As a group, typical LTNPs/ECs have unequivocally reactive HIV-1 Western blots, viral loads below the lower threshold of clinical assays, low levels of persistent viral reservoirs, an over-representation of protective HLA alleles, and robust HIV-specific CD8+ T-cell responses. Th
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6

Michel, Katherine Gisella, Bing Ma, Kathleen Weber, et al. "4117 UNIQUE VAGINAL MICROBIOME POPULATIONS AND MICROBIAL GENE CONTENT AMONG WOMEN WHO NATURALLY CONTROL HIV PROGRESSION." Journal of Clinical and Translational Science 4, s1 (2020): 20–21. http://dx.doi.org/10.1017/cts.2020.102.

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OBJECTIVES/GOALS: The role of the vaginal microbiome (VM) in HIV disease progression is poorly understood. We examined VMs of HIV+ Elite Controllers (ECs) and HIV+ Long-Term Non-Progressors (LTNPs) compared to controls: HIV-positive antiretroviral (ARV) treated (HIV+ATs) and HIV-negative women in the Women’s Interagency HIV Study (DC/Chicago/Atlanta sites). METHODS/STUDY POPULATION: VMs were surveyed via both V3/V4 region of 16S rRNA gene amplicon sequencing and metagenomics sequencing in 67 women across 4 study groups: 1) LTNPs (CD4 >500 cells/mL for 5+ years without ARVs) (n = 7) and 2) E
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7

Tobiume, Minoru, Mikako Takahoko, Takeshi Yamada, Masashi Tatsumi, Aikichi Iwamoto, and Michiyuki Matsuda. "Inefficient Enhancement of Viral Infectivity and CD4 Downregulation by Human Immunodeficiency Virus Type 1 Nef from Japanese Long-Term Nonprogressors." Journal of Virology 76, no. 12 (2002): 5959–65. http://dx.doi.org/10.1128/jvi.76.12.5959-5965.2002.

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ABSTRACT It has been reported that patients infected with nef-defective human immunodeficiency virus type 1 (HIV-1) do not progress to AIDS; however, mutations that abrogate Nef expression are not common in long-term nonprogressors (LTNPs). We postulated that Nef function might be impaired in LTNPs, irrespective of the presence or absence of detectable amino acid sequence anomalies. To challenge this hypothesis we compared in vitro function of nef alleles that were derived from three groups of Japanese patients: LTNPs, progressors, and asymptomatic carriers (ACs). The patient-derived nef allel
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8

Jiang, Yongjun, Xiaojian Cui, Chen Cui, et al. "The Function of CD3+CD56+NKT-Like Cells in HIV-Infected Individuals." BioMed Research International 2014 (2014): 1–9. http://dx.doi.org/10.1155/2014/863625.

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CD3+CD56+NKT-like cells are one of the critical effectors in the immune response to viral infection and tumors, but the functional features of NKT-like cells in HIV infection have been rarely reported. In this study, we observed and described the state of NKT-like cell functions in primary HIV-infected individuals (PHIs), chronic HIV-infected individuals (CHIs), long-term nonprogressors (LTNPs), and HIV-negative controls (NCs). The results showed that the percentage of IFN-γ+CD3+CD56+NKT-like cells was notably higher in LTNPs compared with CHIs, and the proportion of CD3+CD56+NKT-like cells wi
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9

Zhang, Ji-Yuan, Zheng Zhang, Xicheng Wang, et al. "PD-1 up-regulation is correlated with HIV-specific memory CD8+ T-cell exhaustion in typical progressors but not in long-term nonprogressors." Blood 109, no. 11 (2007): 4671–78. http://dx.doi.org/10.1182/blood-2006-09-044826.

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Abstract The immunoreceptor PD-1 is significantly up-regulated on exhausted CD8+ T cells during chronic viral infections such as HIV-1. However, it remains unknown whether PD-1 expression on CD8+ T cells differs between typical progressors (TPs) and long-term nonprogressors (LTNPs). In this report, we examined PD-1 expression on HIV-specific CD8+ T cells from 63 adults with chronic HIV infection. We found that LTNPs exhibited functional HIV-specific memory CD8+ T cells with markedly lower PD-1 expression. TPs, in contrast, showed significantly up-regulated PD-1 expression that was closely corr
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10

de Quiros, Juan Carlos Lopez Bernaldo, W. Lesley Shupert, Andrew C. McNeil, et al. "Resistance to Replication of Human Immunodeficiency Virus Challenge in SCID-Hu Mice Engrafted with Peripheral Blood Mononuclear Cells of Nonprogressors Is Mediated by CD8+T Cells and Associated with a Proliferative Response to p24 Antigen." Journal of Virology 74, no. 4 (2000): 2023–28. http://dx.doi.org/10.1128/jvi.74.4.2023-2028.2000.

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ABSTRACT High levels of resistance to challenge with human immunodeficiency virus type 1 SF162 were observed in animals engrafted with peripheral blood mononuclear cells of four long-term nonprogressors (LTNPs). Resistance was abrogated by depletion of CD8+ T cells in vivo and was observed only in LTNPs with proliferative responses to p24. In a subgroup of nonprogressors, CD8+ T cells mediated restriction of challenge viruses, and this response was associated with strong proliferative responses to p24 antigen.
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11

Lefrère, Jean-Jacques, Laurence Morand-Joubert, Martine Mariotti, et al. "Even Individuals Considered as Long-Term Nonprogressors Show Biological Signs of Progression After 10 Years of Human Immunodeficiency Virus Infection." Blood 90, no. 3 (1997): 1133–40. http://dx.doi.org/10.1182/blood.v90.3.1133.

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Abstract Despite a decade of human immunodeficiency virus (HIV) seropositivity, a few individuals termed as long-term nonprogressors (LTNPs) maintain a stable CD4+ T-cell count for a period of time. The aim of this study was to establish, through the sequential determination of all known predictors of HIV disease, the proportion of such patients having stringent criteria of true long-term nonprogression. Among 249 individuals who were HIV-infected and prospectively followed up over a 10-year period (1985 to 1995), 12 having a CD4+ T-cell count greater than 500/μL (LTNP I group) and 9 having a
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12

Lefrère, Jean-Jacques, Laurence Morand-Joubert, Martine Mariotti, et al. "Even Individuals Considered as Long-Term Nonprogressors Show Biological Signs of Progression After 10 Years of Human Immunodeficiency Virus Infection." Blood 90, no. 3 (1997): 1133–40. http://dx.doi.org/10.1182/blood.v90.3.1133.1133_1133_1140.

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Despite a decade of human immunodeficiency virus (HIV) seropositivity, a few individuals termed as long-term nonprogressors (LTNPs) maintain a stable CD4+ T-cell count for a period of time. The aim of this study was to establish, through the sequential determination of all known predictors of HIV disease, the proportion of such patients having stringent criteria of true long-term nonprogression. Among 249 individuals who were HIV-infected and prospectively followed up over a 10-year period (1985 to 1995), 12 having a CD4+ T-cell count greater than 500/μL (LTNP I group) and 9 having a CD4+ T-ce
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13

Gaardbo, Julie C., Hans J. Hartling, Jan Gerstoft, and Susanne D. Nielsen. "Thirty Years with HIV Infection—Nonprogression Is Still Puzzling: Lessons to Be Learned from Controllers and Long-Term Nonprogressors." AIDS Research and Treatment 2012 (2012): 1–14. http://dx.doi.org/10.1155/2012/161584.

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In the early days of the HIV epidemic, it was observed that a minority of the infected patients did not progress to AIDS or death and maintained stable CD4+ cell counts. As the technique for measuring viral load became available it was evident that some of these nonprogressors in addition to preserved CD4+ cell counts had very low or even undetectable viral replication. They were therefore termed controllers, while those with viral replication were termed long-term nonprogressors (LTNPs). Genetics and virology play a role in nonprogression, but does not provide a full explanation. Therefore, h
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14

Pilotti, Elisabetta, Lisa Elviri, Elisa Vicenzi, et al. "Postgenomic up-regulation of CCL3L1 expression in HTLV-2–infected persons curtails HIV-1 replication." Blood 109, no. 5 (2006): 1850–56. http://dx.doi.org/10.1182/blood-2006-07-036046.

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Abstract Leukocytes of persons coinfected with HTLV-2 and HIV-1 secrete chemokines that prevent CCR5-dependent (R5) HIV-1 infection of CD4+ T cells and macrophages, with HTLV-2–induced MIP-1α as dominant HIV-1 inhibitory molecule. Two nonallelic genes code for CCL3 and CCL3L1 isoforms of MIP-1α, and the population-specific copy number of CCL3L1 exerts a profound effect on HIV-1 susceptibility and disease progression. Here, we demonstrate that CCL3L1 is secreted spontaneously by leukocytes of HTLV-2–infected persons and superinduced when cells of HTLV-2/HIV-1 multiply exposed-uninfected seroneg
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15

Migueles, Stephen A., Alisha C. Laborico, Hiromi Imamichi, et al. "The Differential Ability of HLA B*5701+ Long-Term Nonprogressors and Progressors To Restrict Human Immunodeficiency Virus Replication Is Not Caused by Loss of Recognition of Autologous Viral gag Sequences." Journal of Virology 77, no. 12 (2003): 6889–98. http://dx.doi.org/10.1128/jvi.77.12.6889-6898.2003.

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ABSTRACT Although the HLA B*5701 class I allele is highly overrepresented among human immunodeficiency virus (HIV)-infected long-term nonprogressors (LTNPs), it is also present at the expected frequency (11%) in patients with progressive HIV infection. Whether B57+ progressors lack restriction of viral replication because of escape from recognition of highly immunodominant B57-restricted gag epitopes by CD8+ T cells remains unknown. In this report, we investigate the association between restriction of virus replication and recognition of autologous virus sequences in 27 B*57+ patients (10 LTNP
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16

Kramer, Ivan. "What TriggerstransientAIDS in the Acute Phase of HIV Infection andchronicAIDS at the End of the Incubation Period?" Computational and Mathematical Methods in Medicine 8, no. 2 (2007): 125–51. http://dx.doi.org/10.1080/17486700701395461.

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Novel dynamical models are introduced demonstrating that the T helper cell (THC) density drops in the acute infection phase of HIV infection, sometimes causingtransientAIDS, and at the end of the incubation period causingchronicAIDS have a common dynamical cause. The immune system's inability to produce enoughuninfectedTHCs to replace theinfectedones it is destroying causes a drop in the THC densityat any stage of HIV infection. Increases in viral infectivity, probably caused by random mutation of HIV, are shown to drive the progression of the infection. The minimum incubation period for the l
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17

Jin, Xia, Andy Brooks, Huiyuan Chen, Ryan Bennett, Richard Reichman, and Harold Smith. "APOBEC3G/CEM15 (hA3G) mRNA Levels Associate Inversely with Human Immunodeficiency Virus Viremia." Journal of Virology 79, no. 17 (2005): 11513–16. http://dx.doi.org/10.1128/jvi.79.17.11513-11516.2005.

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ABSTRACT APOBEC3G/CEM15 (hA3G) is a novel host factor that confers resistance to lentiviral infection under experimental conditions. Human immunodeficiency virus (HIV) type 1, however, produces viral infectivity factor (Vif) that targets hA3G for proteolysis, thereby escaping this defense system. To examine hA3G's contribution to the protection against HIV disease progression in humans, we quantified hA3G mRNA levels in peripheral blood mononuclear cells from 6 HIV-uninfected and 25 HIV-infected subjects; the latter group included 8 long-term nonprogressors (LTNPs) and 17 progressors. None of
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18

Oh, Myoung-Don, Sung Soon Kim, Eun Young Kim, et al. "The frequency of mutation in CCR5 gene among Koreans." International Journal of STD & AIDS 11, no. 4 (2000): 266–67. http://dx.doi.org/10.1258/0956462001915688.

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To better understand a role of the Delta32 allele of the CCR5 gene in HIV-1 transmission and disease progression, we determined the CCR5 genotypes within several groups of Koreans. Amplification of DNA from each subject was achieved with polymerase chain reaction, using the CCR5 specific primer pair, which flanks the 32 bp deletion. The 1.2 kb coding sequences of CCR5 were examined to see the possible effects of CCR5 polymorphism. All of the 339 healthy, HIV-uninfected individuals had no mutation in the CCR5 gene. All of the 115 HIV-1-infected patients including 11 long-term non-progressors (L
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19

Bello, Gonzalo, Concepción Casado, Virginia Sandonis, et al. "A subset of human immunodeficiency virus type 1 long-term non-progressors is characterized by the unique presence of ancestral sequences in the viral population." Journal of General Virology 86, no. 2 (2005): 355–64. http://dx.doi.org/10.1099/vir.0.80410-0.

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Within human immunodeficiency virus type 1 (HIV-1)-infected patients, there are those who have been infected for more than 10 years with a CD4+ cell count of >500 cells μl−1 and who remain asymptomatic without antiretroviral therapy; these patients are designated long-term non-progressors (LTNPs). In a set of 16 LTNPs, viral dating, DNA viral load, quasispecies heterogeneity and antibody (Ab) titres against gp160 and β 2 microglobulin (β 2m) were determined. Plasma viral RNA and CD4+ and CD8+ T-cell numbers were estimated in more than three samples per patient. Host genetic characteristics,
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20

Jiménez-Sousa, María, José Jiménez, Amanda Fernández-Rodríguez, et al. "VDR rs2228570 Polymorphism Is Related to Non-Progression to AIDS in Antiretroviral Therapy Naïve HIV-Infected Patients." Journal of Clinical Medicine 8, no. 3 (2019): 311. http://dx.doi.org/10.3390/jcm8030311.

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Background: Vitamin D is a fundamental regulator of host defenses by activating genes related to innate and adaptive immunity. In this study, we analyzed the association among single nucleotide polymorphisms (SNPs) in the vitamin D receptor (VDR) gene, with clinical patterns of AIDS progression in antiretroviral treatment (ART)-naïve HIV-infected patients. Methods: We conducted a retrospective study in 667 HIV-infected patients, who were classified within three groups according to their AIDS progression pattern (183 long-term non-progressors (LTNPs), 334 moderate progressors (MPs), and 150 rap
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21

Pantaleo, Giuseppe, Mauro Vaccarezza, Cecilia Graziosi, Oren J. Cohen, and Anthony S. Fauci. "Antiviral immunity in HIV-1 infected long-term non-progressors (LTNPs)." Seminars in Virology 7, no. 2 (1996): 131–38. http://dx.doi.org/10.1006/smvy.1996.0017.

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22

Bagaglio, S., S. Ghezzi, S. Lodrini, et al. "Hepatitis C virus infection in HIV-infected long term non progressors (LTNPS)." Journal of Hepatology 38 (April 2003): 125. http://dx.doi.org/10.1016/s0168-8278(03)80694-3.

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23

Patel, P., M. Brooks, G. Anabwani, and M. A. Tolle. "Control and non-progression of HIV-1 infection in sub-Saharan Africa: A case and review." Southern African Journal of HIV Medicine 13, no. 3 (2012): 152–55. http://dx.doi.org/10.4102/sajhivmed.v13i3.130.

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Elite and viraemic controllers represent unique subsets of HIV-infected patients who may also be long-term non-progressors (LTNPs). LNTPs constitute an estimated 1 - 15% of the total HIV-positive population in the USA and Europe, but less is known about their epidemiology in sub-Saharan Africa. Though the exact mechanisms for long-term non-progression appear to be numerous and are still under investigation, research on elite controllers may hold the key to new therapeutics and vaccine development. The clinical management of such patients can be challenging, as there are no standard guidelines
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Jiang, Yongjun, Fangyuan Zhou, Yao Tian та ін. "Higher NK Cell IFN-γ Production is Associated with Delayed HIV Disease Progression in LTNPs". Journal of Clinical Immunology 33, № 8 (2013): 1376–85. http://dx.doi.org/10.1007/s10875-013-9930-1.

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EVANS-MOLINA, CARMELLA, ZEB I. SAEED, JAY SOSENKO, et al. "348-OR: Metabolic Phenotype of Autoantibody Positive (AbPos) Long-Term Nonprogressors (LTNPs) to Type 1 Diabetes (T1D)." Diabetes 69, Supplement 1 (2020): 348—OR. http://dx.doi.org/10.2337/db20-348-or.

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26

Wang, Zheng, Tian-yi Li, Jing-yun Li, et al. "Similar neutralizing activity in the HIV-1 infected long term non-progressors(LTNPs) and typical progressors(TPs)." Virologica Sinica 27, no. 3 (2012): 165–71. http://dx.doi.org/10.1007/s12250-012-3239-8.

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Juang, Feng Renn, Yean Kuen Fang, and Yong Jie Zhong. "In situ indium-induced crystallisation of low temperature nano-poly silicon (LTNPS) thin film on ITO glass substrate." International Journal of Nanotechnology 11, no. 12 (2014): 1056. http://dx.doi.org/10.1504/ijnt.2014.065131.

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Sandonís, Virginia, Concepción Casado, Tamara Alvaro, et al. "A combination of defective DNA and protective host factors are found in a set of HIV-1 ancestral LTNPs." Virology 391, no. 1 (2009): 73–82. http://dx.doi.org/10.1016/j.virol.2009.05.022.

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29

De La Torre, Erick. "PONENCIA: ESTRATEGIAS PARA LOGRAR UNA CURA FUNCIONAL DEL VIH." Revista Médica Panacea 7, no. 3 (2019): 116. http://dx.doi.org/10.35563/rmp.v7i3.259.

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Hace 35 años que conocemos a este virus y aún no hemos conseguido doblegarlo por completo. Sin embargo hay mucha investigación en este campo cuyo objetivo es contribuir a encontrar una cura funcional para la infección, que consiste en limitar el tamaño del reservorio viral y controlar la carga viral a través de una respuesta inmunológica adecuada (1). Entre un 2 – 5 % de los pacientes que están infectados por el VIH, son denominados LTNPs (long term non-progressors o progresores lentos), los cuales son capaces de mantener niveles altos de células T CD4 y/o baja carga viral sin estar en tratami
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Ayala-Suárez, Rubén, Francisco Díez-Fuertes, Esther Calonge, et al. "Insight in miRNome of Long-Term Non-Progressors and Elite Controllers Exposes Potential RNAi Role in Restraining HIV-1 Infection." Journal of Clinical Medicine 9, no. 8 (2020): 2452. http://dx.doi.org/10.3390/jcm9082452.

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Long-term non-progressors (LTNP) and elite controllers (EC) represent spontaneous natural models of efficient HIV-1 response in the absence of treatment. The main purposes of this work are to describe the miRNome of HIV-1 infected patients with different extreme phenotypes and identify potentially altered pathways regulated by differentially expressed (DE) miRNAs. The miRNomes from peripheral blood mononuclear cells (PBMCs) of dual phenotype EC-LTNP or LTNP with detectable viremia and HIV-infected patients with typical progression before and after treatment, were obtained through miRNA-Seq and
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Sauer, Steffen, Robert English, and Mark Clatworthy. "The Ratio of Tibial Slope and Meniscal Bone Angle for the Prediction of ACL Reconstruction Failure Risk." Surgery Journal 04, no. 03 (2018): e152-e159. http://dx.doi.org/10.1055/s-0038-1668111.

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Background A growing body of research is indicating that the tibial slope and the geometry of the tibiofemoral meniscal–cartilage interface may affect the risk of anterior cruciate ligament reconstruction (ACLR) failure. Increased lateral tibial posterior slope (LTPS) and reduced meniscal bone angle (MBA) are associated with increased risk of anterior cruciate ligament (ACL) injury. The significance of a LTPS–MBA ratio regarding the prediction of ACL failure risk remains unknown. As LTPS and MBA may eventually potentiate or neutralize each other, it is expected that a low LTPS–MBA ratio is ass
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Mishra, Ankita, and Ashok Kumar. "Mapping B-Cell Epitopes for Nonspecific Lipid Transfer Proteins of Legumes Consumed in India and Identification of Critical Residues Responsible for IgE Binding." Foods 10, no. 6 (2021): 1269. http://dx.doi.org/10.3390/foods10061269.

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Nonspecific lipid transfer proteins (nsLTPs) have been categorized as panallergens and display widespread occurrence across plant-kingdom. Present study, investigated B-cell epitopes for LTPs from chickpea, mung-bean, cowpea, pigeon-pea, and soybean via in silico methods. In-silico predicted regions were evaluated for epitope-conservancy and property-based peptide similarity search by different allergen databases. Additionally, the in-silico predicted regions were compared with the experimentally validated epitopes of peach-LTP. Sequence-homology studies showed that chickpea and mung-bean LTPs
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Akhiyarova, Guzel R., Ekaterina I. Finkina, Tatiana V. Ovchinnikova, Dmitry S. Veselov, and Guzel R. Kudoyarova. "Role of Pea LTPs and Abscisic Acid in Salt-Stressed Roots." Biomolecules 10, no. 1 (2019): 15. http://dx.doi.org/10.3390/biom10010015.

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Lipid transfer proteins (LTPs) are a class of small, cationic proteins that bind and transfer lipids and play an important role in plant defense. However, their precise biological role in plants under adverse conditions including salinity and possible regulation by stress hormone abscisic acid (ABA) remains unknown. In this work, we studied the localization of LTPs and ABA in the roots of pea plants using specific antibodies. Presence of LTPs was detected on the periphery of the cells mainly located in the phloem. Mild salt stress (50 mM NaCI) led to slowing plant growth and higher immunostain
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Das, Koushik, Natsuki Watanabe, and Tomoyoshi Nozaki. "Two StAR-related lipid transfer proteins play specific roles in endocytosis, exocytosis, and motility in the parasitic protist Entamoeba histolytica." PLOS Pathogens 17, no. 4 (2021): e1009551. http://dx.doi.org/10.1371/journal.ppat.1009551.

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Lipid transfer proteins (LTPs) are the key contributor of organelle-specific lipid distribution and cellular lipid homeostasis. Here, we report a novel implication of LTPs in phagocytosis, trogocytosis, pinocytosis, biosynthetic secretion, recycling of pinosomes, and motility of the parasitic protist E. histolytica, the etiological agent of human amoebiasis. We show that two StAR-related lipid transfer (START) domain-containing LTPs (named as EhLTP1 and 3) are involved in these biological pathways in an LTP-specific manner. Our findings provide novel implications of LTPs, which are relevant to
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Finkina, E. I., D. N. Melnikova, I. V. Bogdanov, and T. V. Ovchinnikova. "Lipid Transfer Proteins As Components of the Plant Innate Immune System: Structure, Functions, and Applications." Acta Naturae 8, no. 2 (2016): 47–61. http://dx.doi.org/10.32607/20758251-2016-8-2-47-61.

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Among a variety of molecular factors of the plant innate immune system, small proteins that transfer lipids and exhibit a broad spectrum of biological activities are of particular interest. These are lipid transfer proteins (LTPs). LTPs are interesting to researchers for three main features. The first feature is the ability of plant LTPs to bind and transfer lipids, whereby these proteins got their name and were combined into one class. The second feature is that LTPs are defense proteins that are components of plant innate immunity. The third feature is that LTPs constitute one of the most cl
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Swathirajan, Chinnambedu Ravichandran, Ramachandran Vignesh, Greer Waldrop, et al. "HIV-specific T-cell Responses and Generalized Activation in HIV-1 Infected Long-term Non-progressors and Progressors from South India." Current HIV Research 16, no. 4 (2019): 302–14. http://dx.doi.org/10.2174/1570162x17666181212122607.

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Background:Anti-viral cytokine expressions by cytotoxic T-cells and lower activation rates have been reported to correlate with suppressed HIV replication in long-term non-progressors (LTNP). Immune mechanisms underlying disease non-progression in LTNP might vary with HIV-1 subtype and geographical locations.Objective:This study evaluates cytokine expression and T-cells activation in relation to disease non-progression in LTNP.Methods:HIV-1 Subtype C infected LTNP (n=20) and progressors (n=15) were enrolled and flowcytometry assays were performed to study HIV-specific CD8 T-cells expressing IL
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37

Koli, Katri, Juha Saharinen, Mira Kärkkäinen та Jorma Keski-Oja. "Novel non-TGF-β-binding splice variant of LTBP-4 in human cells and tissues provides means to decrease TGF-β deposition". Journal of Cell Science 114, № 15 (2001): 2869–78. http://dx.doi.org/10.1242/jcs.114.15.2869.

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Small latent TGF-β consists of latency associated peptide (LAP) bound to the 25 kDa TGF-β by noncovalent interactions. Small latent TGF-β is secreted from cells and deposited into the extracellular matrix as covalent complexes with its binding proteins, LTBPs. Four LTBPs have been molecularly cloned and their structures contain repetitive sequences. The 3rd 8-Cys repeats of LTBP-1, -3 and -4 are able to associate with small latent TGF-β. We analyzed by RT-PCR the expression of LTBPs 1-4 in a panel of cultured human cell lines including fibroblasts of different origin, endothelial cells and imm
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38

Panoutsakopoulou, Vily, Kathryn Hunter, Thomas G. Sieck, Elizabeth P. Blankenhorn, and Kenneth J. Blank. "Genetic Regulation of Long-Term Nonprogression in E-55+ Murine Leukemia Virus Infection in Mice." Journal of Virology 73, no. 11 (1999): 9232–36. http://dx.doi.org/10.1128/jvi.73.11.9232-9236.1999.

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ABSTRACT Certain inbred mouse strains display progression to lymphoma development after infection with E-55+ murine leukemia virus (E-55+ MuLV), while others demonstrate long-term nonprogression. This difference in disease progression occurs despite the fact that E-55+ MuLV causes persistent infection in both immunocompetent BALB/c–H-2k (BALB.K) progressor (P) and C57BL/10–H-2k (B10.BR) long-term nonprogressor (LTNP) mice. In contrast to immunocompetent mice, immunosuppressed mice from both P and LTNP strains develop lymphomas about 2 months after infection, indicating that the LTNP phenotype
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39

Kang, Seok, Ha-Mok Jeong, Beom-Suk Kim, and Joon-Shik Yoon. "Risk Analysis of Needle Injury to the Long Thoracic Nerve during Ultrasound-Guided C7 Selective Nerve Root Block." Medicina 57, no. 6 (2021): 635. http://dx.doi.org/10.3390/medicina57060635.

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Background and Objectives: Ultrasound (US)-guided cervical selective nerve root block (SNRB) is a widely used treatment for upper limb radicular pain. The long thoracic nerve (LTN) passes through the middle scalene muscle (MSM) at the C7 level. The needle trajectory of US-guided C7 SNRB pierces the MSM, therefore indicating a high probability of injury to the LTN. We aimed to identify the LTN and to investigate the risk of needle injury to the nerve during US-guided C7 SNRB. Materials and Methods: This retrospective observational study included 30 patients who underwent US-guided SNRB at the C
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40

Pii, Youry, Tiziana Pandolfini, and Massimo Crimi. "Signaling LTPs: A new plant LTPs sub-family?" Plant Signaling & Behavior 5, no. 5 (2010): 594–97. http://dx.doi.org/10.4161/psb.11499.

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41

Zhang, Qian, Wenchun Jiang, and Yanting Zhang. "Effect of geometrical parameters on the effective elastic modulus for an X-type lattice truss panel structure." Science and Engineering of Composite Materials 25, no. 6 (2018): 1135–44. http://dx.doi.org/10.1515/secm-2017-0257.

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AbstractThe lattice truss panel structure (LTPS), which is a high strength material with high efficiency of heat transfer, has a good potential to be used as compact heat exchanger. The core of LTPS is a periodic porous structure, and the effective elastic modulus (EEM) will be different from the base material. It is essential to calculate the EEM for the design of this type of heat exchanger. This paper presents a study on the EEM of X-type LTPS by homogenization method, which has been verified by finite element method (FEM). It reveals that the effects of seven geometrical parameters of the
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42

Broström, Christina, Anders Sönnerborg, Stefan Lindbäck, and Hans Gaines. "Low Relative Frequencies of CD26+CD4+ Cells in Long-Term Nonprogressing Human Immunodeficiency Virus Type 1-Infected Subjects." Clinical Diagnostic Laboratory Immunology 5, no. 5 (1998): 662–66. http://dx.doi.org/10.1128/cdli.5.5.662-666.1998.

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ABSTRACT A broad antibody panel was used for immunophenotyping of human immunodeficiency virus type 1 (HIV-1)-infected patients who were long-term nonprogressors (LTNP). The LTNP were compared with patients in the early phase of infection and patients who had progressed to advanced immunodeficiency. Changes in CD8+ subset distribution were observed mainly at acquisition of HIV-1 infection, whereas CD4+ subset changes appeared during progression of HIV-1 infection. The decreasing levels of CD4+ cells were characterized by an increasing frequency of cells expressing the activation markers HLA-Dr
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Jang, Kyungsoo, Youngkuk Kim, Pham Duy Phong, Younjung Lee, Joonghyun Park, and Junsin Yi. "Improvement of Electrical Performance in P-Channel LTPS Thin-Film Transistor with a-Si:H Surface Passivation." Materials 12, no. 1 (2019): 161. http://dx.doi.org/10.3390/ma12010161.

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We report the effects of surface passivation by depositing a hydrogenated amorphous silicon (a-Si:H) layer on the electrical characteristics of low temperature polycrystalline silicon thin film transistors (LTPS TFTs). The intrinsic a-Si:H layer was optimized by hydrogen dilution and its structural and electrical characteristics were investigated. The a-Si:H layer in the transition region between a-Si:H and µc-Si:H resulted in superior device characteristics. Using a-Si:H passivation layer, the field-effect mobility of the LTPS TFT was increased by 78.4% compared with conventional LTPS TFT. Mo
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44

Zhu, Kai, Peng Peng, Ning Wu, Xianrong Zhou, Jianfei Mu, and Xin Zhao. "Preventive Effect of Liupao Tea Polyphenols on HCl/Ethanol-Induced Gastric Injury in Mice." Journal of Food Quality 2020 (February 11, 2020): 1–10. http://dx.doi.org/10.1155/2020/5462836.

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Liupao tea is a traditional Chinese tea drink. The preventive effect of crude polyphenols in Liupao tea on HCl/ethanol-induced gastric injury was investigated in this study. After a model of gastric injury in mice was established, mouse serum and tissues were analyzed by biochemical and molecular biological methods. The results showed that Liupao tea polyphenols (LTPs) could effectively reduce the area of gastric mucosal lesions, decrease the volume of gastric juice, and increase the pH of gastric juice in mice with gastric injury. Observations of the pathology revealed that LTPs could allevia
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Li, Shaohua, Wenchun Jiang, Xiaolei Zhu, and Xuefang Xie. "Experimental and Analytical Analysis of Mechanical Properties for Large-Size Lattice Truss Panel Structure Including Role of Connected Structure." Materials 14, no. 17 (2021): 5099. http://dx.doi.org/10.3390/ma14175099.

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The large-size lattice truss panel structure (LTPS) is continually increasing for higher upsizing, but the roles of its connected structures on the mechanical properties are always ignored during the previous structural integrity assessment. Thus, in this paper, a series of mechanical tests, including the fabricating of panel-to-panel LTPSs, monotonous tensile, and three- and four-point bending tests, were performed to comprehensively understand the mechanical behavior. Furthermore, a theoretical model including the role of connected structures was developed to predict both the elastic and pla
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Uchikoga, Shuichi. "Low-Temperature Polycrystalline Silicon Thin-Film Transist or Technologies for System-on-Glass Displays." MRS Bulletin 27, no. 11 (2002): 881–86. http://dx.doi.org/10.1557/mrs2002.277.

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AbstractThe elimination of conventional peripheral LSI (large-scale integration) drivers is considered essential to the development of future low-cost, energy-efficient, lightweight, and thin displays. System-on-glass (SOG) displays are a type of display with various functional circuits integrated on a glass substrate. Low-temperature polycrystalline silicon (LTPS) thin-film transistors (TFTs) make the integration of circuits possible because they can be assembled into complex, high-current driver circuits. Furthermore, LTPS TFTs are attracting attention for driving organic light-emitting devi
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47

Crotti, Andrea, Francesca Neri, Davide Corti, et al. "Nef Alleles from Human Immunodeficiency Virus Type 1-InfectedLong-Term-Nonprogressor Hemophiliacs with or without Late Disease Progression Are Defective in Enhancing Virus Replication and CD4 Down-Regulation." Journal of Virology 80, no. 21 (2006): 10663–74. http://dx.doi.org/10.1128/jvi.02621-05.

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ABSTRACT Infection with human immunodeficiency virus (HIV)-encoding defective nef variants may contribute to a relatively benign course of disease in a minority of long-term nonprogressors (LTNP). We have examined the functions of nef alleles from six individuals belonging to the same cohort of hemophiliacs infected with HIV-1 prior to 1985 and classified as LTNP in 1995. Three out of six individuals have progressed to HIV disease (late progressors [LP]), whereas the three remainders have maintained their LTNP status at least up to 2003. The nef alleles were obtained from both plasma virus and
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48

Jagannathan, Prasanna, Christine M. Osborne, Cassandra Royce, et al. "Comparisons of CD8+ T Cells Specific for Human Immunodeficiency Virus, Hepatitis C Virus, and Cytomegalovirus Reveal Differences in Frequency, Immunodominance, Phenotype, and Interleukin-2 Responsiveness." Journal of Virology 83, no. 6 (2009): 2728–42. http://dx.doi.org/10.1128/jvi.02128-08.

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ABSTRACT To better understand the components of an effective immune response to human immunodeficiency virus (HIV), the CD8+ T-cell responses to HIV, hepatitis C virus (HCV), and cytomegalovirus (CMV) were compared with regard to frequency, immunodominance, phenotype, and interleukin-2 (IL-2) responsiveness. Responses were examined in rare patients exhibiting durable immune-mediated control over HIV, termed long-term nonprogressors (LTNP) or elite controllers, and patients with progressive HIV infection (progressors). The magnitude of the virus-specific CD8+ T-cell response targeting HIV, CMV,
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49

ÖKLÜ, Rahmi, та Robin HESKETH. "The latent transforming growth factor β binding protein (LTBP) family". Biochemical Journal 352, № 3 (2000): 601–10. http://dx.doi.org/10.1042/bj3520601.

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The transforming growth factor β (TGFβ) cytokines are a multi-functional family that exert a wide variety of effects on both normal and transformed mammalian cells. The secretion and activation of TGFβs is regulated by their association with latency-associated proteins and latent TGFβ binding proteins (LTBPs). Over the past few years, three members of the LTBP family have been identified, in addition to the protoype LTBP1 first sequenced in 1990. Three of the LTBP family are expressed in a variety of isoforms as a consequence of alternative splicing. This review summarizes the differences betw
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50

Cooper, Joseph D., Wei Wang, Heather A. Prentice, Tadashi T. Funahashi, and Gregory B. Maletis. "The Association Between Tibial Slope and Revision Anterior Cruciate Ligament Reconstruction in Patients ≤21 Years Old: A Matched Case-Control Study Including 317 Revisions." American Journal of Sports Medicine 47, no. 14 (2019): 3330–38. http://dx.doi.org/10.1177/0363546519878436.

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Background: There is evidence that tibial slope may play a role in revision risk after anterior cruciate ligament reconstruction (ACLR); however, prior studies are inconsistent. Purpose: To determine (1) whether there is a difference in lateral tibial posterior slope (LTPS) or medial tibial posterior slope (MTPS) between patients undergoing revised ACLR and those not requiring revision and (2) whether the medial-to-lateral slope difference is different between these 2 groups. Study Design: Case-control study; Level of evidence, 3. Methods: We conducted a matched case-control study (2006-2015).
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