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Journal articles on the topic 'Lu jiang cao tang'

Author: Grafiati

Published: 28 July 2024

Last updated: 31 July 2025

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1

Chai, Jing, Chen-Qi Lu, Mu-Rong Yi, et al. "Discovery of a wild, genetically pure Chinese giant salamander creates new conservation opportunities." Zoological research 43, no. 3 (2022): 469–80. https://doi.org/10.24272/j.issn.2095-8137.2022.101.

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Chai, Jing, Lu, Chen-Qi, Yi, Mu-Rong, Dai, Nian-Hua, Weng, Xiao-Dong, Di, Ming-Xiao, Peng, Yong, Tang, Yong, Shan, Qing-Hua, Wang, Kai, Liu, Huan-Zhang, Zhao, Hai-Peng, Jin, Jie-Qiong, Cao, Ru-Jun, Lu, Ping, Luo, Lai-Chun, Murphy, Robert W, Zhang, Ya-Ping, Che, Jing (2022): Discovery of a wild, genetically pure Chinese giant salamander creates new conservation opportunities. Zoological research 43 (3): 469-480, DOI: 10.24272/j.issn.2095-8137.2022.101, URL: http://dx.doi.org/10.24272/j.issn.2095-8137.2022.101

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Zhu, Chaodong, Arong Luo, Ming Bai, et al. "A joint call for actions to advance taxonomy in China." Zoological Systematics 47, no. 3 (2022): 188–97. https://doi.org/10.11865/zs.2022302.

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Zhu, Chaodong, Luo, Arong, Bai, Ming, Orr, Michael C., Hou, Zhonge, Ge, Siqin, Chen, Jun, Hu, Yibo, Zhou, Xuming, Qiao, Gexia, Kong, Hongzhi, Lu, Limin, Jin, Xiaohua, Cai, Lei, Wei, Xinli, Zhao, Ruilin, Miao, Wei, Wang, Qingfeng, Sha, Zhongli, Lin, Qiang, Qu, Meng, Jiang, Jianping, Li, Jiatang, Che, Jing, Jiang, Xuelong, Chen, Xiaoyong, Gao, Lianming, Ren, Zongxin, Xiang, Chunlei, Luo, Shixiao, Wu, Donghui, Liu, Dong, Peng, Yanqiong, Su, Tao, Cai, Chenyang, Zhu, Tianqi, Cai, Wanzhi, Liu, Xingyue, Li, Hu, Xue, Huaijun, Ye, Zhen, Chen, Xuexin, Tang, Pu, Wei, Shujun, Pang, Hong, Xie, Qiang, Zhang

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3

Jhang, Jing-Siang, Hanoch Livneh, Shu-Yi Yang, et al. "Decreased risk of colorectal cancer among patients with type 2 diabetes receiving Chinese herbal medicine: a population-based cohort study." BMJ Open Diabetes Research & Care 8, no. 1 (2020): e000732. http://dx.doi.org/10.1136/bmjdrc-2019-000732.

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ObjectivesPatients with type 2 diabetes have a higher risk of colorectal cancer (CRC), but whether Chinese herbal medicines (CHMs) can reduce this risk is unknown. This study investigated the effect that CHMs have on CRC risk in patients with type 2 diabetes.Research design and methodsThis cohort study used the Taiwanese National Health Insurance Research Database to identify 54 744 patients, newly diagnosed with type 2 diabetes, aged 20–70 years, who were receiving treatment between 1998 and 2007. From this sample, we randomly selected 14 940 CHMs users and 14 940 non-CHMs users, using propen

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Li, Hsin-Hua, Hanoch Livneh, Wei-Jen Chen, et al. "Chinese Herbal Medicine to Reduce Radiation-Induced Oral Mucositis in Head and Neck Cancer Patients: Evidence From Population-Based Health Claims." Integrative Cancer Therapies 20 (January 2021): 153473542110448. http://dx.doi.org/10.1177/15347354211044833.

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Background: Subjects with head and neck cancer (HNC) often experience post-treatment side effects, particularly radiation-induced oral mucositis (RIOM). This study aimed to explore the association of Chinese herbal medicine use with the sequent risk of RIOM among them. Methods: This cohort study used a nationwide health insurance database to identify subjects newly diagnosed with HNC, aged 20 to 60 years, who received treatment between 2000 and 2007. Among them, a total of 561 cases received CHM after HNC onset (CHM users); the remaining 2395 cases were non-CHM users. All patients were followe

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Villagran, Ignacio. "“Sturdy Boulders that Protect the Realm” Early Medieval Chinese Thinkers on Decentralized Governance." Early Medieval China 24, no. 1 (2018): 82–107. https://doi.org/10.1353/emc.2018.a943126.

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Abstract: The period between the formal end of the Han dynasty in 220 ce and the reestablishment of unified imperial authority in the Sui-Tang period (late sixth century ce) is considered one of political fragmentation and recurrent military conflict. During three centuries, several kingdoms and short-lived dynasties were established and destroyed, either by military conquest or by court intrigues and coups. In this context, many political thinkers of the time looked back to the long rule of the Han as a time of peace and prosperity, and argued that it was the institutions of centralized gover

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Tang, Lu-Xin, Yi-Zhe Zhang, Jia-Qi Liang, Shao-Feng Jiang, Jing Si, and Hai-Jiao Li. "Pyrofomes lagerstroemiae (Polyporaceae, Basidiomycota), a new species from Hubei Province, Central China." Phytotaxa 583, no. 2 (2023): 191–98. https://doi.org/10.11646/phytotaxa.583.2.7.

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Tang, Lu-Xin, Zhang, Yi-Zhe, Liang, Jia-Qi, Jiang, Shao-Feng, Si, Jing, Li, Hai-Jiao (2023): Pyrofomes lagerstroemiae (Polyporaceae, Basidiomycota), a new species from Hubei Province, Central China. Phytotaxa 583 (2): 191-198, DOI: 10.11646/phytotaxa.583.2.7, URL: http://dx.doi.org/10.11646/phytotaxa.583.2.7

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Yan, Feng, Tao Jiang, Tao Liang, et al. "Abstract 3318: GFH375 (VS-7375): An oral, selective KRAS G12D (ON/OFF) inhibitor with potent anti-tumor efficacy." Cancer Research 84, no. 6_Supplement (2024): 3318. http://dx.doi.org/10.1158/1538-7445.am2024-3318.

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Abstract Background: KRAS is the best-known oncogene but had long been considered ‘undruggable’ until the approval of the first KRAS G12C inhibitor sotorasib in 2021. However, most current clinical-stage KRAS inhibitors target the KRAS G12C mutation. Inhibitors of other KRAS mutants such as KRAS G12D, the most frequent KRAS mutation in human cancer, are needed for patients. We have developed GFH375 (VS-7375), an oral, selective KRAS G12D inhibitor targeting both “ON” (GTP-bound) and “OFF” (GDP-bound) states of KRAS proteins. The in vitro potency, selectivity, and in vivo efficacy of monotherap

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8

Lu, Yunyang, Xuefeng He, Yang Liu, et al. "Steriodal saponins from the rhizomes of Tupistra chinensis Baker." Phytochemistry 207 (March 31, 2023): 1–8. https://doi.org/10.1016/j.phytochem.2022.113583.

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Lu, Yunyang, He, Xuefeng, Liu, Yang, Cao, Yu, Qiu, Pengcheng, Yuan, Xiaofeng, Lu, Qiangqiang, Tang, Haifeng, Yang, Hua (2023): Steriodal saponins from the rhizomes of Tupistra chinensis Baker. Phytochemistry (113583) 207: 1-8, DOI: 10.1016/j.phytochem.2022.113583, URL: http://dx.doi.org/10.1016/j.phytochem.2022.113583

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Zhou, Si-Xuan, Dan-Feng Bao, Tao Zhang, et al. "Two new endophytic fungi of Colletotrichum and Diaporthe isolated from Berchemia polyphylla var. leioclada in Guizhou Province, China." Phytotaxa 640, no. 1 (2024): 1–15. https://doi.org/10.11646/phytotaxa.640.1.1.

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Zhou, Si-Xuan, Bao, Dan-Feng, Zhang, Tao, Xiao, Yuan-Pin, Tang, Yuan-Jiang, Jing, Zhang, Lu, Yu-Xi, Shi, Kai-Zhi (2024): Two new endophytic fungi of Colletotrichum and Diaporthe isolated from Berchemia polyphylla var. leioclada in Guizhou Province, China. Phytotaxa 640 (1): 1-15, DOI: 10.11646/phytotaxa.640.1.1, URL: http://dx.doi.org/10.11646/phytotaxa.640.1.1

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Peng, Changjun, Dong-Dong Wu, Jin-Long Ren, et al. "Large-scale snake genome analyses provide insights into vertebrate development." Cell 186 (June 30, 2023): 1–18. https://doi.org/10.1016/j.cell.2023.05.030.

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Peng, Changjun, Wu, Dong-Dong, Ren, Jin-Long, Peng, Zhong-Liang, Ma, Zhifei, Wu, Wei, Lv, Yunyun, Wang, Zeng, Deng, Cao, Jiang, Ke, Parkinson, Christopher L., Qi, Yin, Zhang, Zhi-Yi, Li, Jia-Tang (2023): Large-scale snake genome analyses provide insights into vertebrate development. Cell 186: 1-18, DOI: 10.1016/j.cell.2023.05.030, URL: http://dx.doi.org/10.1016/j.cell.2023.05.030

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Hussain, Nabihah, Mohd Rashidi Salim, Asrul Izam Azmi, et al. "Performance of Graphene Nanopowder-Polyvinyl Alcohol in Optical Pulse Generation at 1.5 Micron Region." Photonics Letters of Poland 13, no. 3 (2021): 55. http://dx.doi.org/10.4302/plp.v13i3.1113.

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This paper explains about the performance of graphene nanopowder (GNP) based saturable absorber (SA) at 1.5-micron region which is prepared by dissolution in polyvinyl alcohol (PVA) polymer. Two different GNP flakes thickness (AO2-8 nm and AO4-60 nm) are tested. By applying a solution casting method, three weight ratio of GNP to PVA (12.04, 8.03 and 3.11 wt.%) have been prepared and fabricated as a composite thin film. To characterize for the SA performance, 4 mm2 area of GNP-PVA thin film is embedded in a 14 meters long ring cavity with 3 meters Erbium doped fiber (EDF) as a gain medium. Our

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Pirrone, Noemi, Sara Garcia Ballesteros, Simelys Hernandez, and Federico Bella. "Electrochemical Ammonia Production from Wastewater in a Flow Cell Reactor." ECS Meeting Abstracts MA2023-02, no. 47 (2023): 2322. http://dx.doi.org/10.1149/ma2023-02472322mtgabs.

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Although its high carbon footprint, the Haber-Bosh (HB) process mainly dominates the NH3 production market. Indeed, H2 is mainly produced by fossil fuels steam reforming processes and the catalytic reaction between N2 and H2 requires high energy input, being carried out at high temperatures and pressures. Moreover, it should be considered that HB plants are not evenly distributed in the world, thus NH3 and its derivates transportation to the final user is a large portion of the overall environmental impact.1 Moreover, as the population is growing, the NH3 demand is increasing fast to sustain t

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Бедова, Евгения Валерьевна, Евгения Андреевна Тонких та Олег Александрович Козадеров. "Электрохимическое окисление муравьиной кислоты на поверхности анодно-модифицированного сплава Ag15Pd". Kondensirovannye sredy i mezhfaznye granitsy = Condensed Matter and Interphases 22, № 2 (2020): 204–10. http://dx.doi.org/10.17308/kcmf.2020.22/2832.

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Показано, что фазовое превращение палладия в собственную фазу при селективном растворении сплава Ag15Pd протекает в режиме мгновенной нуклеации и лимитируется поверхностной диффузией ад-атомов Pd к растущему трехмерному зародышу новой фазы. С применением нестационарных электрохимических методов установлены кинетические закономерности процесса электроокисления муравьиной кислоты на сплаве Ag15Pd, подвергнутом предварительному селективному растворению. Найдено, что процесс анодной деструкции НСООН в кислом сульфатном растворе протекает с более высокой скоростью на анодно-модифицированном сплаве

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14

Chen, Daixu. "Textual Borrowing of Aftertime Literati from the Nineteen Old Poems." Communications in Humanities Research 24, no. 1 (2024): 262–69. http://dx.doi.org/10.54254/2753-7064/24/20231779.

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The Nineteen Old Poems, hailed as the crown jewel of five-character lines, has left an indelible mark on countless poets of subsequent generations, inspiring an array of imitative works. This paper aims to explore the diverse practices of textual borrowing from the Nineteen Old Poems across three distinct historical periods: the late Han and Wei-Jin periods (Cao brothers, Ruan Ji, Lu Ji), the Tang dynasty (Li Bai, Wei Yingwu), and the Ming dynasty (He Jingming, Li Panlong, and others among the Earlier and Later Seven Masters). By selecting representative imitative poems from these poets and co

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KANAKI, Michiko, Akira IMADAYA, and Katsutoshi TERASAWA. "Two cases of paralytic ileus treated with intra rectal administration of Hon-Pu-Sheng-Jiang-Ban-Xia-Gan-Cao-Ren-Shen Tang." Kampo Medicine 38, no. 3 (1988): 163–69. http://dx.doi.org/10.3937/kampomed.38.163.

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16

Zhang, Qianpeng, Daquan Zhang, Xiaofei Sun, Beitao Ren, and Zhiyong Fan. "(Invited, Digital Presentation) High-Efficiency and Stable Perovskite LEDs and Displays with Nanophotonic Methods." ECS Meeting Abstracts MA2022-02, no. 36 (2022): 1308. http://dx.doi.org/10.1149/ma2022-02361308mtgabs.

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Perovskite light-emitting diodes (PeLEDs) have experienced rapid development in the past 8 years. The external quantum efficiencies (EQEs) of red, green, and near-infrared (NIR) PeLEDs have all surpassed the 20% milestone. Meanwhile, the blue PeLEDs also achieved EQEs higher than 10% and are catching up quickly with PeLEDs of other colors. However, there are still two key problems remaining within the PeLEDs for their further development, namely the light extraction problem and the short lifetime problem. Therefore, in this report, we will discuss our recent work targeting addressing the above

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Cao, Zhiyuan, Chengfei Pu, Xianyang Jiang, et al. "Abstract 2838: Antigen-independent expansion enhances efficacy of CAR-T cells against solid tumor." Cancer Research 82, no. 12_Supplement (2022): 2838. http://dx.doi.org/10.1158/1538-7445.am2022-2838.

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Abstract One key hurdle for the CAR-T cell treatment of solid tumors is the limited accessibility of solid tumor antigens outside the tumor microenvironment, which prohibits the expansion of solid tumor-targeting CAR-T cells in patients. Here, we report the characterization of prostatic acid phosphatase (PAP) as a feasible CAR-T target for prostate cancer and a novel approach, named CoupledCAR, to expand solid tumor-targeting CAR-T cells lacking solid tumor antigens based on the observation of non-transduced T cells proliferating together with CD19 CAR-T cells during the treatment of acute lym

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Zeng, Zhiyuan. "Electrochemical Lithium Intercalation & Exfoliation in 2D TMDs and Its in-Situ Studies." ECS Meeting Abstracts MA2024-01, no. 12 (2024): 978. http://dx.doi.org/10.1149/ma2024-0112978mtgabs.

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We developed a lithium ion battery intercalation & exfoliation method with detailed experimental procedures for the mass production of 11 two dimensional TMDs and inorganic nanosheets, such as MoS2, WS2, TiS2, TaS2, ZrS2, graphene, h-BN, NbSe2, WSe2, Sb2Se3 and Bi2Te3, among them 3 TMDs achieved mono- or double layer yield > 90%. This method involves the electrochemical intercalation of lithium ions into layered inorganic materials and a mild sonication process. The Li insertion can be monitored and finely controlled in the battery testing system, so that the galvanostatic discharge pro

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Zhou, Feng, Lu Liu, Lei Jiang та ін. "Abstract 512: Identification of SS008871, a novel Polθ inhibitor that effectively inhibits tumors with homologous recombination deficiency in vitro and in vivo". Cancer Research 83, № 7_Supplement (2023): 512. http://dx.doi.org/10.1158/1538-7445.am2023-512.

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Abstract The repair of DNA double strand break (DSB) is crucial for genome stability and cell survival. There are three main DSB repair pathways: homologous recombination (HR), non-homologous end joining (NHEJ) and microhomology-mediated end joining (MMEJ). HR is a high-fidelity, error-free DSB repair pathway, and the dysfunction of HR confers cell genome instability and leads to tumorigenesis. HR deficiency is especially prevalent in gynecologic tumors, sharing about 10% population of all the gynecologic tumor patients. In situation of HR deficiency, MMEJ, in which DNA polymerase theta (Polθ)

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Muramatsu, Keisuke, and Wataru Sugimoto. "Direct Surface Sulfidation of Layered Metal Hydroxides Using Bis(trimethylsilyl) Sulfide." ECS Meeting Abstracts MA2024-02, no. 69 (2024): 4843. https://doi.org/10.1149/ma2024-02694843mtgabs.

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Layered transition metal hydroxides have been extensively researched for applications such as electrodes and electrocatalysts owing to their tunable redox properties based on various cation compositions. To control critical physical properties such as chemical adsorption and conductivity in these applications, topochemical control of anion compositions will be effective. While many reports have demonstrated the synthesis of nitrides and sulfides by reacting layered metal hydroxides with different anion sources, the existing methods often result in the formation of microcrystalline aggregates.1

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Badia, Antonella. "Parity Effects in the Interfacial Electrochemistry of Redox-Active Monolayers: When the Odds Change." ECS Meeting Abstracts MA2025-01, no. 50 (2025): 2502. https://doi.org/10.1149/ma2025-01502502mtgabs.

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Surface-immobilized monolayer assemblies of ferrocenylated molecules have garnered significant interest as systems for charge transport and storage, information processing, and current rectification due to fast interfacial electron transfer, low oxidation potential, and two stable redox states.1-3 The electrochemical oxidation of the monolayer-bound ferrocene (Fc) to ferrocenium (Fc+) involves coupled electron transfer and ion pairing reactions: Fcmonolayer + X- (aq) → (Fc+X-)monolayer + e-.4 Counteranions X- from solution pair with the ferroceniums to stabilize these oxidized cations and neut

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Seredin, Pavel V., Dmitry L. Goloshchapov, Kirill A. Nikitkov, Vladimir M. Kashkarov, Yury A. Ippolitov та Vongsvivut Jitraporn (Pimm). "Применение синхротронной ИК-микроспектроскопии для анализа интеграции биомиметических композитов с нативной твердой тканью зуба человека". Kondensirovannye sredy i mezhfaznye granitsy = Condensed Matter and Interphases 21, № 2 (2019): 262–77. http://dx.doi.org/10.17308/kcmf.2019.21/764.

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В данной работе продемонстрирована возможность применения ИК-микроспектроскопии для многомерной визуализации и анализа интеграции с нативными твердыми тканями зуба человека нового поколения биомиметических материалов, воспроизводящих минералорганический комплекс эмали и дентина.На основе ИК-картирования интенсивности конкретной функциональной молекулярной группы с использованием синхротронного излучения найдены и визуализированы характеристические особенности биомиметического переходного слоя в межфазной области эмаль/стоматологический материал и определено расположение функциональных групп, о

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Menga, Davide, Sunmoon Yu, and Yang Shao-Horn. "Electrochemical CO₂ Reduction Reaction to Methanol on a Molecular Cobalt Catalyst." ECS Meeting Abstracts MA2024-02, no. 62 (2024): 4203. https://doi.org/10.1149/ma2024-02624203mtgabs.

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Our society is currently facing critical challenges regarding CO2 emissions and drastic changes in the way we produce energy, chemicals and materials are required in order to tackle global warming. The electrochemical reduction of CO2 is a key reaction in order to reduce our carbon footprint and a great scientific effort is being made to improve our knowledge and understanding about this complicated process. Recently, cobalt phthalocyanine (CoPc) has drawn tremendous attention due to its capability to electrochemically reduce CO2 and CO to methanol (1-6), a key molecule in the chemical manufac

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Dai, Enyu, Jiang-Jiang Qin, Jibo Wu, et al. "Abstract 1305: Cellular and molecular landscape of metastatic gastric cancer." Cancer Research 83, no. 7_Supplement (2023): 1305. http://dx.doi.org/10.1158/1538-7445.am2023-1305.

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Abstract Metastases from gastric adenocarcinoma (GAC) lead to high morbidity and mortality in the clinic. However, to date, the study of primary tumors with matched metastases from GAC patients has not been conducted, mainly because the collection of such samples in clinics is extremely challenging. To understand the evolution of metastatic cells and their interactions with the tumor microenvironment (TME), we performed paired single-cell transcriptome and immune profiling of primary tumors, matched liver metastases (LM) and/or peritoneal carcinomatosis (PC), adjacent normal, and blood specime

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Lu, Haizhen, Dong Kuang, Lili Jiang, et al. "Abstract 5463: The PD-L1 protein expression in Chinese patients with recurrent or metastatic head and neck squamous cell carcinoma: A multi-center retrospective study." Cancer Research 83, no. 7_Supplement (2023): 5463. http://dx.doi.org/10.1158/1538-7445.am2023-5463.

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Abstract Programmed death-ligand 1 (PD-L1) is a trans-membrane protein and co-inhibitory factor of the immune response. PD-L1 can combine with its receptor (PD-1) to reduce the proliferation of PD-1-positive cells and induce apoptosis. Therefore, PD-L1 was employed as a prognostic marker and a target for anti-cancer immunotherapy in blocking the PD-1 and PD-L1 checkpoints. PD-L1 is highly expressed in various malignancies, including head and neck squamous cell carcinoma (HNSCC). HNSCC is the sixth most common cancer worldwide, with high incidence and mortality rates in China. Although PD-L1 ex

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Li, Ziming, Xiaomin Dang, Dingzhi Huang, et al. "Abstract CT246: Open-label, single-arm, multicenter, phase 2 trial of garsorasib in KRAS G12C-mutated non-small-cell lung cancer." Cancer Research 84, no. 7_Supplement (2024): CT246. http://dx.doi.org/10.1158/1538-7445.am2024-ct246.

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Abstract Background: Garsorasib (D-1553), a potent KRAS G12C inhibitor, has previously demonstrated promising anti-tumor activity in KRAS G12C-mutated non-small-cell lung cancer (NSCLC) in a phase 1 study. Here we present the efficacy and safety of garsorasib in a pivotal phase 2 study. Methods: In this open-label, multicenter, single-arm phase 2 study, patients received garsorasib 600 mg twice daily in 21-day cycles. Eligible criteria included patients with locally advanced or metastatic NSCLC harboring KRAS G12C mutation, who had disease progression after prior anti-PD-(L)1 therapy and plati

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Tang, Mingcong, and Liang An. "Engineering Electrode/Electrolyte Interface in Zn Metal Batteries." ECS Meeting Abstracts MA2025-01, no. 6 (2025): 700. https://doi.org/10.1149/ma2025-016700mtgabs.

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Engineering Electrode/Electrolyte Interface in Zn Metal Batteries Mingcong Tanga, Liang Ana,b* a Department of Mechanical Engineering, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR, China b Research Institute for Advanced Manufacturing, The Hong Kong Polytechnic University, Hung Hong, Kowloon, Hong Kong SAR, China *Corresponding author. Abstract Attributed to favorable redox potential (-0.76 V vs. standard hydrogen electrode)(1), inherent safety, outstanding theoretical capacity (820 mAh g-1 or 5855 mAh cm-3)(2) and abundant reserve of zinc metals(3), aqueous zinc meta

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Yang, Cuiqing, Yifang Wang, Tingting Liu, et al. "Abstract 2899: Small molecule inhibitor of ubiquitin ligase CBL-B enhanced anti-tumor response of CAR-T and CAR-NK cell therapies." Cancer Research 83, no. 7_Supplement (2023): 2899. http://dx.doi.org/10.1158/1538-7445.am2023-2899.

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Abstract Introduction: Chimeric antigen receptor (CAR) T-cell therapy is an emerging therapeutic option for cancer treatment. However, its efficacy is limited, especially in solid tumors. This is partly because the CAR T cells become dysfunctional and exhausted in the tumor microenvironment. However, the key pathways responsible for impaired function of exhausted T cells remain unclear. Immunosuppressive cytokines or checkpoint proteins like TGF-β and PD-L1, are overproduced, which may lead to the downregulation of CD8+ T cell action and the promotion of T-reg maturation. E3 ligase Casitas B-L

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Xue, Liyan, Jiaqi Wang, Dong Kuang, et al. "Abstract 2180: The PD-L1 protein expression in Chinese patients with advanced esophageal cancers: a multi-center retrospective study." Cancer Research 83, no. 7_Supplement (2023): 2180. http://dx.doi.org/10.1158/1538-7445.am2023-2180.

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Abstract Introduction: Programmed cell death ligand-1 (PD-L1) is the ligand of programmed cell death-1 (PD-1), a member of the immunoglobulin gene superfamily that plays a role in programmed cell death. Accumulating evidence of anti-PD-1 therapy has showed improved survival benefit for esophageal cancer (EC) patients. PD-L1 has emerged as a crucial predictor for efficacy of immunotherapy. However, the understanding of PD-L1 as a biomarker is complicated by various immunohistochemistry platforms, PD-L1 antibodies, scoring systems, and cut-offs for immunotherapy. Although PD-L1 expression has be

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Fu, Yayuan, Chaochao Cen, Lei Jiang, et al. "Abstract 2965: SCR-A006, an innovative and potential best-in-class EGFR/cMet bispecific antibody-drug conjugate." Cancer Research 85, no. 8_Supplement_1 (2025): 2965. https://doi.org/10.1158/1538-7445.am2025-2965.

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Abstract Background: EGFR and cMet are widely co-expressed in solid tumors, and there is crosstalk between their signaling pathways, which is the general escape mechanism for each other in clinic. Although various drugs targeting EGFR and/or cMet have been approved or are in clinical development, primary and acquired resistance limits their prolonged efficacy. There still remains a large unmet need in solid tumor therapy. SCR-A006 is an antibody-drug conjugate (ADC) comprising a bispecific mAb targeting EGFR&cMET conjugated to a topoisomerase 1 inhibitor (TOP1i) via a cleavable and hydroph

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Zhou, Feng, Lu Liu, Lei Jiang та ін. "Abstract 4539: ZM-2311 a novel and highly potent Polθ inhibitor demonstrates synergistically anti-tumor activities in combination with different therapeutics". Cancer Research 84, № 6_Supplement (2024): 4539. http://dx.doi.org/10.1158/1538-7445.am2024-4539.

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Abstract Homologous recombination (HR) is a high-fidelity DNA double-strand break (DSB) repair pathway, and its dysfunction leads to cell genome instability and can result in tumorigenesis. In the situation of HR deficiency, DNA polymerase theta (Polθ) mediated microhomology-mediated end joining (MMEJ) is up-regulated to serve as a backup pathway for DSB repair. Several studies have proved that the inhibition of Polθ causes synthetic lethality with HR deficiency, and Polθ emerges as a potential DNA damage repair (DDR) target for the treatment of HR deficient tumors. In addition, there is evide

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Li, Huiping, Hope S. Rugo, Jin Zhang, et al. "Interpreting Advanced Breast Cancer Consensus Guidelines for Use in China." Journal of Global Oncology 2, no. 3_suppl (2016): 36s—37s. http://dx.doi.org/10.1200/jgo.2016.004028.

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Abstract 58 Background: In 2011, an international panel of breast cancer experts developed the first Advanced Breast Cancer (ABC) Consensus Guidelines to provide standards and improved care for the multidisciplinary care of patients with this common disease. We sought to adapt the ABC guidelines for China, incorporating cultural standards and available Chinese resource, and identifying suitable formed guideline. Methods: We organized the Chinese Consensus Guidelines Conference for ABC (CABC) yearly from 2013 through 2015 in Beijing as a joint effort between the China Medical Women's Associatio

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Zhou, Feng, Lu Liu, Lei Jiang, et al. "Abstract 591: Discovery of ZM-2322, a highly selective, potent inhibitor of membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (PKMYT1)." Cancer Research 84, no. 6_Supplement (2024): 591. http://dx.doi.org/10.1158/1538-7445.am2024-591.

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Abstract The genome DNA is consistently threatened by a variety of intrinsic and exogenous DNA damage factors. Cell cycle checkpoint is one important mechanism in response to DNA damage and maintaining genome stability. In tumor cells, gene alterations, such as CCNE1 amplification (encoding for Cyclin E1), result in G1/S checkpoint loss and replication stress, leading to high dependency on the G2/M checkpoint. PKMYT1 inhibits crucial checkpoint protein CDK1 activity by phosphorylating CDK1 at the residues of Thr-14 and Tyr-15 in the G2/M phase. In CCNE1 amplification cells, the inhibition of P

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Yang, Cuiqing, Fuwei Jiang, Yifang Wang, et al. "Abstract 2900: To develop a next generation NK therapy with deep and durable response by engineered CD16 enhancing NK cytotoxicity." Cancer Research 83, no. 7_Supplement (2023): 2900. http://dx.doi.org/10.1158/1538-7445.am2023-2900.

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Abstract Introduction: Allogeneic NK cell-based therapies have been demonstrated to elicit clinical efficacy against hematopoietic malignancies. Unlike T-cell therapies, allogeneic NK cells do not cause toxicities such as serious cytokine release syndrome, neurotoxicity, or graft-vs-host-disease, and are less expensive. We believe NK cell-based therapies provide an important platform for “off-shelf” allogeneic cell therapies, so we designed a panel of arming strategies to enhance NK cytotoxicity and elicit deep and durable response. CD16a is a transmembrane protein that co-localizes with CD3ζ

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Yang, Cuiqing, Fuwei Jiang, Yifang Wang, et al. "Abstract 4087: Co-expression of membrane bound IL-15 enhanced anti-tumor response of CAR-T." Cancer Research 83, no. 7_Supplement (2023): 4087. http://dx.doi.org/10.1158/1538-7445.am2023-4087.

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Abstract Introduction: Chimeric antigen receptors (CARs) T cells have been used successfully to treat patients with hematologic malignancies, but showed less effective in solid tumors. We investigated multiple approaches to engineer and enhance CAR-T activity in solid tumors. It has been previously reported that improvement in the quality of CAR-T cells, through CAR design or manufacturing optimization, could enhance the therapeutic potential of CAR-T cells. One parameter influencing the effectiveness of CAR-T cell therapy is the differentiation status of the final product: CAR-T cells that ar

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Yang, Cuiqing, Yifang Wang, Tingting Liu, et al. "Abstract 4078: Optimized chimeric antigen receptors (CARs) for CAR-NK cell therapies." Cancer Research 83, no. 7_Supplement (2023): 4078. http://dx.doi.org/10.1158/1538-7445.am2023-4078.

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Abstract Introduction: CAR-T-cell therapy has shown great success in treating hematopoietic malignancies. Allogenic NK cell-based therapies have also been shown to mount potent responses against hematopoietic malignancies. Unlike T-cell therapies, allogeneic NK cells do not cause toxicities such as serious cytokine release syndrome, neurotoxicity, or graft-vs-host-disease. Several groups have demonstrated the clinical efficacy of allogeneic CAR-expressing NK cells that utilize CARs developed for T-cells. However, activating receptor signaling in NK cells is different from T cells. NK cell-medi

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Jiang, Yujie, Kaixian Yu, Matthew D. Montierth, et al. "Abstract 4272: Pan-cancer analysis of intra-tumor heterogeneity in 9,116 cancers using a novel regularized likelihood model." Cancer Research 83, no. 7_Supplement (2023): 4272. http://dx.doi.org/10.1158/1538-7445.am2023-4272.

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Abstract Subpopulations of tumor cells characterized by mutation profiles may confer differential fitness and consequently influence the prognosis of cancers. Understanding subclonal architecture has the potential to provide biological insight in tumor evolution and advance cancer precision treatment. Recent subclonal reconstruction methods require heavy computational resources, prior knowledge of the number of subclones, and extensive postprocessing. These drawbacks can be addressed by using a regularized likelihood modeling approach, which is novel to the field. Therefore, we propose a model

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Montierth, Matthew, Yujie Jiang, Kaixian Yu, et al. "Abstract 7153: Subclonal mutation load predicts survival and response to immunotherapy in cancers with low to moderate TMB." Cancer Research 85, no. 8_Supplement_1 (2025): 7153. https://doi.org/10.1158/1538-7445.am2025-7153.

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Abstract Immune checkpoint inhibitors (ICI) have revolutionized cancer treatment, yet current biomarkers like tumor mutation burden (TMB) and mismatch repair deficiency identify responders in only a small fraction of patients, particularly in low-to-moderate TMB cancers. This is critical as the majority of cancer patients (ex. approximately 90% of TCGA) have TMB&lt;10, the FDA-approved threshold for ICI therapy. As such, there is need to identify biomarkers to predict immunotherapy response in these currently overlooked patients.We developed CliPP, a novel statistical machine learning appr

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Sazinsky, Steve, Phuong Nguyen, Mohammad Zafari, et al. "886 Targeting VSIG4, a novel macrophage checkpoint, repolarizes suppressive macrophages which induces an inflammatory response in primary cell in vitro assays and fresh human tumor cultures." Journal for ImmunoTherapy of Cancer 9, Suppl 2 (2021): A928. http://dx.doi.org/10.1136/jitc-2021-sitc2021.886.

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BackgroundVSIG4 (V-set immunoglobulin-domain-containing 4) is a B7 family related protein with known roles as a complement receptor involved in pathogen clearance as well as a negative regulator of T cell activation by an undetermined mechanism.1–3 VSIG4 is expressed in tumor associated macrophages (TAMs) with exquisite specificity. In cancer, increased expression of VSIG4 has been associated with worse survival in multiple indications, including non-small cell lung cancer, multiple myeloma, ovarian cancer, and glioma, suggesting an important role in tumor immune evasion.3–6 Based upon computa

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Huang, Lei, Lili Shi, Yajun Sun, et al. "Abstract 2702: GQ1001 is a next generation HER2-targeting ADC with excellent druggability, safety and potency." Cancer Research 83, no. 7_Supplement (2023): 2702. http://dx.doi.org/10.1158/1538-7445.am2023-2702.

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Abstract Background: GQ1001 was developed to overcome the current limitation of existing HER2 ADCs by using the next generation site-specific conjugation and a stable linker technology, coined the intelligent ligase-dependent conjugation (iLDC) technology. iLDC provides a robust platform for the generation of ADC with high homogeneity and excellent stability. Our data show that GQ1001 is highly homogeneous with strong anti-tumor potency, more importantly, markedly enhanced linker stability and reduced off-target toxicity, and points to a safer HER2 ADC with a larger therapeutic window in human

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Cheng, Ying, Jie Wang, Caicun Zhou, et al. "Abstract CT038: Adebrelimab or placebo plus carboplatin and etoposide as first-line treatment for extensive-stage SCLC: A phase 3 trial." Cancer Research 82, no. 12_Supplement (2022): CT038. http://dx.doi.org/10.1158/1538-7445.am2022-ct038.

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Abstract Introduction: Extensive-stage small cell lung cancer (ES-SCLC) is associated with limited treatment options and poor prognosis. Immunotherapy has recently showed robust clinical activity in ES-SCLC. In this double-blind, phase 3 trial, we evaluated adebrelimab (SHR-1316), a novel anti-PD-L1 antibody, in combination with standard chemotherapy (chemo) as first-line treatment for ES-SCLC. Methods: Patients naïve to systemic treatment for ES-SCLC were randomized 1:1 to receive 4-6 cycles of adebrelimab (20 mg/kg, iv, d1, q3w) or placebo with carboplatin (AUC 5, d1, q3w) plus etoposide (10

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Hung, *Yun Ting, Mei Yi Lee, Ming Huan Chan, and Hwei Hsien Chen. "BETAINE ALLEVIATES CUE-INDUCED REINSTATEMENT OF KETAMINE SEEKING VIA AMPK ACTIVATION IN THE NUCLEUS ACCUMBENS CORE." International Journal of Neuropsychopharmacology 28, Supplement_1 (2025): i308—i309. https://doi.org/10.1093/ijnp/pyae059.549.

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Abstract Background Betaine is a functional nutrient with a variety of potential health benefits1.2. It has been shown to attenuate the reinstatement of ketamine-seeking behavior in rats3. Moreover, betaine activates AMP-activated protein kinase (AMPK) and functions as a partial agonist of the NMDA receptor glycine binding site, both of which have been associated with reducing cue-induced reinstatement4.5.6. Aims & Objectives The study aimed to both identify the brain regions associated with betaine's reduction effect on cue-induced reinstatement of ketamine seeking and to explore the invo

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Zheng, Chao, Dandan Ma, Linfeng Zhao, et al. "Abstract P4-03-31: Lifestyle factors are associated with breast cancer risk in women biopsied for benign breast diseases in China: 10-year results of a multi-center, hospital-based, case-control study." Cancer Research 83, no. 5_Supplement (2023): P4–03–31—P4–03–31. http://dx.doi.org/10.1158/1538-7445.sabcs22-p4-03-31.

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Abstract Objective: Benign breast disease (BBD), especially benign proliferative breast disease (BPBD), is related to increased breast cancer risk. However, few studies have examined whether conventional breast cancer risk factors influence risk of breast cancer among women with BBD. The aim of this study was to evaluate the associations of lifestyle factors with risk of breast cancer among women biopsied for BBD within a multi-center, hospital-based, case-control study in China, in order to provide scientific basis of health guidance for BBD patients and lay the foundation for primary prevent

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Ying, Bixian, Pranti Sutar, Peter Nagel, Stefan Schuppler, and Karin Kleiner. "(Digital Presentation) Investigations into the Capacity Degradation Due to an Electronic Structural Change in Homogenous Boron-Substituted Ni-Rich Layered Oxides." ECS Meeting Abstracts MA2022-01, no. 4 (2022): 519. http://dx.doi.org/10.1149/ma2022-014519mtgabs.

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Ni-rich layered oxides (LiNixCoyMnzO2, x≥0.8, x+y+z=1) would fulfil the energy density requirements of the automobile industry since they offer outstanding capacities at relatively high mean voltages and sufficient power densities1-3. However, the materials still show significant capacity and voltage fade which requires substantial research. Recently we have shown that the electronic structure is the key to understand the performance but also the failure of the materials1. Thus, we intend to modify the electronic structure using anionic dopants such as Boron. Thus, homogenous B-substituted NCM

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Sengupta, Abhinanda, Ajit Kumar, Aakash Ahuja, Harshita Lohani, Pratima Kumari, and Abhinanda Sengupta. "Co-Free Heteroatom-Doped P2-Type Layered Oxide Cathodes: Advancing High Power Sodium-Ion Battery Technology." ECS Meeting Abstracts MA2023-02, no. 65 (2023): 3095. http://dx.doi.org/10.1149/ma2023-02653095mtgabs.

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Sodium-ion battery technology has been blooming as an indigenous solution to stationary storage applications, triggering the cultivation of a cutting-edge alternative to the archaic lithium-ion (Li-ion) batteries due to high abundance, inexpensiveness, sustainability, safety and similar redox chemistry as of Li-ion technology 1. Although Na-ion batteries are propitious however, challenges such as long-term stability, high energy density, high specific capacity have impeded the practical application 2. The stepping stone for a successful Na-ion battery lies in the cathode, thus researchers have

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Rawat, Sunil Kumar, Monica Marinescu, Gregory James Offer, Simon E. J. O'Kane, and Ruihe Li. "How to Design a Zero-Degradation Battery: Compensating for Loss of Lithium Inventory in LFP Cells with LFO Additives." ECS Meeting Abstracts MA2025-01, no. 5 (2025): 610. https://doi.org/10.1149/ma2025-015610mtgabs.

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Loss of lithium inventory (LLI) caused by side reactions in lithium-ion cells is one of the primary reasons behind their capacity fade and shorter cycle life. Research in academia and industry has explored additives such as Lithium Iron oxide (Li₅FeO₄) in LFP-based battery chemistries that sacrifice their lithium inventory to compensate for LLI. Over the last ~15 years [1-4], research has proven that LFO can compensate for LLI and help maintain stable cell performance, and more recently, CATL & Rimac [5-6] announced its commercial-level usage, claiming to have achieved zero degradation for

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Quarrell, Matthew James, Robert Batty, Alex R. Neale, Daniel Harvey, Dmitry Shchukin, and Laurence J. Hardwick. "Integration of Micro-Encapsulated Phase Change Materials into Thin Coatings for a Passive Battery Thermal Management System." ECS Meeting Abstracts MA2025-01, no. 8 (2025): 835. https://doi.org/10.1149/ma2025-018835mtgabs.

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Battery thermal management systems (BTMS) are an important component of electric vehicles. BTMS provide key safety measures with the aim of maintaining operating temperatures of Li-ion cells within optimum ranges between 15 – 35 °C and a maximum 5 °C difference across the cell.1 Current commercial BTMS use air or liquid cooling to maintain optimum temperatures of Li-ion cells, which can be bulky, reducing volumetric and gravimetric energy densities of the battery pack. Additionally, the most effective systems, active BTMS, require energy from the battery to pump the cooling fluid resulting in

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Kawai, Kosuke, Yuta Igarashi, Seon Joon Jang, et al. "Proton Intercalation of Mo₃Nb₂O₁₄ Anode for Aqueous Batteries." ECS Meeting Abstracts MA2024-02, no. 9 (2024): 1341. https://doi.org/10.1149/ma2024-0291341mtgabs.

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Energy storage systems are indispensable to power electric devices such as mobile phones, electric vehicles, and smart grids. Lithium-ion battery dominates the largest segment of the energy storage system market owing to its high energy density and long cycle life. However, flammable organic liquid electrolytes are used in lithium-ion batteries, which is an essential risk of fire and explosion accidents. Substituting water solvent for organic solvent directly approaches the safety issue. In particular, proton is the cation with the smallest ionic radius, which enables host materials to be dens

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Alves, Daniele, Eithne Dempsey, and Carmel B. Breslin. "Factorial optimisation of CoCuFe- LDH/graphene composites for water splitting." ECS Meeting Abstracts MA2024-02, no. 42 (2024): 2805. https://doi.org/10.1149/ma2024-02422805mtgabs.

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The increasing energy demand, driven by industrialization and global population growth, has increased the focus on developing clean and sustainable energy sources [1]. Hydrogen (H2) has emerged as a promising alternative to carbon-based fuels due to its low cost, higher calorific value, and absence of pollution emissions [2]. Electrochemical water splitting has recently gained prominence as a highly attractive technique for efficient hydrogen production [3]. Therefore, the development of efficient and cost-effective catalysts for the hydrogen evolution reaction (HER) is crucial for advancing e

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Кузнецов, Сергей Викторович, Алексей Сергеевич Низамутдинов, Эдуард Ильдарович Мадиров та ін. "Исследование люминесценции твердых растворов на основе фторида иттрия, легированных иттербием и европием для фотоники". Kondensirovannye sredy i mezhfaznye granitsy = Condensed Matter and Interphases 22, № 2 (2020): 225–31. http://dx.doi.org/10.17308/kcmf.2020.22/2834.

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Подавляющая часть мирового рынка солнечных фотоэлектрических устройств основывается на кремниевых технологиях. Актуальной задачей является повышение эффективности их работы за счет использования люминесцентных покрытий, в том числе преобразующих излучение из УФ-синей области спектра в ближний инфракрасный диапазон, где кремний поглощает излучение с наибольшей эффективностью (стоксовая, или даун-конверсионная люминесценция) или из инфракрасной области спектра в ближний инфракрасный диапазон (ап-конверсионная люминесценция). Целью данного исследования были синтез и исследование спектрально-кинет

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