Log in

Relevant bibliographies by topics / Luciferine / Dissertations / Theses

To see the other types of publications on this topic, follow the link: Luciferine.

Dissertations / Theses on the topic 'Luciferine'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 dissertations / theses for your research on the topic 'Luciferine.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.

1

Oliveira, Anderson Garbuglio de. "Estudo mecanístico da bioluminescência de fungos." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/46/46135/tde-08112010-093327/.

Full text

Abstract:

Esta tese descreve como é possível obter emissão de luz in vitro enzimaticamente, a partir de extratos quente e frio de diferentes espécies de fungos bioluminescentes, o que indica também um mecanismo comum de bioluminescência em todos esses organismos. Dados cinéticos sugerem um mecanismo enzimático em duas etapas e corroboram a hipótese enzimática de Airth e Foerster, da década de 1960. Finalmente, utilizando-se extratos quente e frio foi possível também isolar a luciferina fúngica e obter sua massa molecular (298,1837 m/z). Essa substância isolada emite luz enzimaticamente in vitro, sendo q

APA, Harvard, Vancouver, ISO, and other styles

2

Chan, Wai Shing. "Applications of the bacterial luciferin-luciferase system." HKBU Institutional Repository, 2012. https://repository.hkbu.edu.hk/etd_ra/1454.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Jathoul, Amit Paul. "Activity of firefly luciferase with 6'-amino-D-luciferin." Thesis, University of Cambridge, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.612384.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Pereira, Tatiana Araujo. "Purificação e caracterização de enzimas envolvidas na bioluminescência de fungos." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/46/46136/tde-12042018-105954/.

Full text

Abstract:

Esta tese descreve estudos realizados na tentativa de purificar e caracterizar enzimas envolvidas na BL de fungos, além de trabalhos conduzidos a fim de investigar o mecanismo da bioluminescência de fungos. Inicialmente, tentou-se isolar as duas enzimas supostamente responsáveis pala reação bioluminescente em fungos. Parâmetros de atividade ótima (pH e temperatura) e comportamento cinético foram investigados. Todavia, com a descoberta de que a luciferina fúngica é o derivado hidroxilado da hispidina (3-hidróxihispidina), novas estratégias foram abordadas. Os esforços se concentraram na purific

APA, Harvard, Vancouver, ISO, and other styles

5

Carvalho, Rodrigo Pimenta. "Purificação, caracterização e estudo mecanístico com luciferina fúngica." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/46/46136/tde-14092016-092016/.

Full text

Abstract:

Este tese descreve métodos para a purificação e determinação da massa molecular do precursor da luciferina fúngica, a partir dos corpos de frutificação do fungo bioluminescente Neonothopanus gardneri. A molécula em questão é o substrato da primeira etapa da reação enzimática responsável pela emissão de luz em fungos, fenômeno conhecido como bioluminescência. Ao longo do projeto, foi otimizado um ensaio analítico qualitativo para detecção do precursor da luciferina em solução, e também foram desenvolvidos métodos de extração e purificação da molécula de interesse, levando sempre em consideração

APA, Harvard, Vancouver, ISO, and other styles

6

Martins, Gabriel Nobrega da Rocha. "Detecção e quantificação de derivados e intermediários de hispidina em fungos bioluminescentes e plantas por LC-MS/MS." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/46/46137/tde-24092018-160058/.

Full text

Abstract:

A bioluminescência desperta o interesse humano há muitos séculos. Presente em quatro dos sete reinos taxonômicos, Monera, Chromista, Animalia e Fungi, cada um com mecanismos muito diferentes. Pode-se dizer que o estudo químico da bioluminescência começou com os experimentos de Dubois no século XIX, que cunhou os termos luciferina e luciferase, termos genéricos para o substrato e enzima envolvidos na reação, respectivamente. No caso específico de fungos, o envolvimento de enzimas foi debatido por quase cinco décadas, após a proposta enzimática de Airth e Foerster na década de 1960 e a não enzim

APA, Harvard, Vancouver, ISO, and other styles

7

Neary, A. P. "Synthesis of luciferins and related compounds." Thesis, University of Sussex, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.374484.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Salatino, Carla Trentini. "Estudo mecanístico da reação de formação da luciferina de vaga-lume." reponame:Repositório Institucional da UFABC, 2017.

Find full text

Abstract:

Orientador: Prof. Dr. Luiz Francisco Monteiro Leite Ciscato<br>Dissertação (mestrado) - Universidade Federal do ABC. Programa de Pós-Graduação em Ciência e Tecnologia/Química, 2017.<br>A reação de produção de luz pelo vaga-lume envolve a oxidação enzimática da Dluciferina, um composto que contém dois anéis tiazólicos; a formação desta D-luciferina em meio biológico acontece por um processo envolvendo a reação de D-cisteína com 2-ciano-6- hidroxibenzotiazol, uma reação de mecanismo ainda desconhecido. Esta reação tem sido empregada na formação eficiente de conjugados entre duas moléculas de ati

APA, Harvard, Vancouver, ISO, and other styles

9

Rylands, Marwaan. "Syntheses of luciferins and their bioluminescent evaluation." Doctoral thesis, University of Cape Town, 2018. http://hdl.handle.net/11427/29197.

Full text

Abstract:

Luciferins are a class of light emitting small molecule substrates. These molecules are oxidised to produce visible light in a reaction catalysed by the luciferase enzymes. The combination of this luminescent reaction coupled with CCD cameras, has produced revolutionary technologies that enable measurements of mammalian gene expression in cells, as well as protein-protein interactions, biochemical labelling, and small molecule flux, to name a few. Of all the luciferin molecules, D-luciferin is the most widely researched. D-Luciferin is the light emitting molecule isolated from the American fir

APA, Harvard, Vancouver, ISO, and other styles

10

Conti, Elena Eliana. "Crystal structure of firefly luciferase." Thesis, Imperial College London, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.244284.

Full text

APA, Harvard, Vancouver, ISO, and other styles

11

Walpole, C. S. J. "Active site probes for bacterial luciferase." Thesis, University of Sussex, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.356510.

Full text

APA, Harvard, Vancouver, ISO, and other styles

12

Mofford, David M. "Pushing The Boundaries of Bioluminescence Using Synthetic Luciferins: A Dissertation." eScholarship@UMMS, 2015. http://escholarship.umassmed.edu/gsbs_diss/794.

Full text

Abstract:

Fireflies are beetles that generate yellow-green light when their luciferase enzyme activates and oxidizes its substrate, D-luciferin. This bioluminescent reaction is widely used as a sensitive reporter both in vitro and in vivo. However, the light-emitting chemistry is limited by the properties of the small molecule D-luciferin. Our lab has developed a panel of synthetic luciferin analogs that improve on the inherent characteristics of D-luciferin. My thesis work focuses on harnessing these novel substrates to further expand the utility and molecular understanding of firefly bioluminescence.

APA, Harvard, Vancouver, ISO, and other styles

13

Lin, Leo Yen-Cheng. "Flavin binding site in Vibrio harveyi Luciferase." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=85083.

Full text

Abstract:

Luciferase catalyzes the emission of blue-green light and is the central feature of bacterial bioluminescence. The three-dimensional structure of the bacterial luciferase apo-enzyme determined by X-ray crystallography has revealed the detailed landscape of the enzyme active site, however, the absence of a structure with bound substrate has impeded the understanding of the enzyme mechanism by which luciferase interacts with substrates and catalyzes their conversion into light emission. This thesis describes three research projects that focus on the molecular conformation of flavin in the

APA, Harvard, Vancouver, ISO, and other styles

14

Meroni, G. "Synthesis of analogues and derivatives of luciferin for imaging techniques." Doctoral thesis, Università degli Studi di Milano, 2009. http://hdl.handle.net/2434/152767.

Full text

Abstract:

The advent of genetic engineering has considerably affected the field of drug discovery and within this field of research, a good success has been the generation of a transgenic (ERE-Luc) mouse that has been transfected with a luciferase reporter gene. Under the control of activated estrogen receptors, this mouse encodes the enzyme luciferase, whose activity can be detected by chemiluminescent methods. The enzyme luciferase is able to catalyze the oxidative decarboxylation of D-luciferin with production of photons. The PhD project was aimed to the synthesis of compounds that should be cha

APA, Harvard, Vancouver, ISO, and other styles

15

Gupta, Rajat. "Firefly luciferase mutants as sensors of proteome stress." Diss., lmu, 2012. http://nbn-resolving.de/urn:nbn:de:bvb:19-150266.

Full text

APA, Harvard, Vancouver, ISO, and other styles

16

Lasko, Daniel R. "On-line fermentation monitoring via recombinant firefly luciferase." Thesis, Massachusetts Institute of Technology, 1995. http://hdl.handle.net/1721.1/11125.

Full text

APA, Harvard, Vancouver, ISO, and other styles

17

Andrews, Thomas. "A novel dual-luciferase monitoring apparatus a thesis /." San Antonio : UTHSC, 2008. http://learningobjects.library.uthscsa.edu/cdm4/item_viewer.php?CISOROOT=/theses&CISOPTR=36&CISOBOX=1&REC=20.

Full text

APA, Harvard, Vancouver, ISO, and other styles

18

Buriánková, Karolína. "Résistance ribosomique aux macrolides et leur effet sur la fidélité de traduction." Paris 11, 2003. http://www.theses.fr/2003PA112220.

Full text

Abstract:

Les macrolides forment un groupe homogène d'agents antibactériens produits par des Streptomyces et d'autres actinomycètes. Ils inhibent la synthèse protéique des bactéries par liaison à la sous-unité ribosomique 50S, ce qui empêche son assemblage ou son fonctionnement. La première partie de ce manuscrit porte sur l'effet des macrolides sur la fidélité de traduction. Nous avons utilisé comme système rapporteur la luciférase de Vibrio harveyi avec un codon stop introduit au début du gène luxB pour mesurer in vivo la suppression de ce codon stop. L'érythromycine augmente la trans-lecture du codon

APA, Harvard, Vancouver, ISO, and other styles

19

Eriksson, Jonas. "Advancements in Firefly Luciferase-Based Assays and Pyrosequencing Technology." Doctoral thesis, KTH, Biotechnology, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-3708.

Full text

Abstract:

<p>Pyrosequencing is a new DNA sequencing method relying on thesequencing-by-synthesis principle and bioluminometric detectionof nucleotide incorporation events. The objective of thisthesis was improvement of the Pyrosequencing method byincreasing the thermal stability of firefly luciferase, and byintroducing an alternative DNA polymerase and a new nucleotideanalog. Furthermore, the development of a new bioluminescentassay is described for the detection of inorganicpyrophosphatase activity.</p><p>The wild-type North American firefly<i>(Photinus pyralis)</i>luciferase is a heat-sensitiveenzyme,

APA, Harvard, Vancouver, ISO, and other styles

20

Farkasova, Katarina. "Bioluminescence imaging of luciferase transgenes in tumor metastases models." Diss., lmu, 2011. http://nbn-resolving.de/urn:nbn:de:bvb:19-139409.

Full text

APA, Harvard, Vancouver, ISO, and other styles

21

Zeng, Jiang. "Chemiluminescence and bioluminescence related to flavins and bacterial luciferase." Thesis, University of Huddersfield, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.387194.

Full text

APA, Harvard, Vancouver, ISO, and other styles

22

Oliveira, Jordana Cristina. "Desenvolvimento de estratégias alternativas para teste de fármacos: obtenção e caracterização de linhagens mutantes estáveis de Leishmania expressando luciferase." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/42/42135/tde-15122014-154829/.

Full text

Abstract:

A leishmaniose é causada por protozoários do gênero Leishmania e no Brasil, as principais espécies causadoras da leishmaniose cutânea são Leishmania (V.) braziliensis e Leishmania (L.) amazonenses. O tratamento da leishmaniose apresenta diversas dificuldades, portanto é fundamental a descoberta de novos fármacos ativos, podendo ser detectada em células cultivadas in vitro e também em animais íntegros, através da técnica de bioimageamento. Neste trabalho, propusemo-nos a produzir linhagens de L. (V.) braziliensis e L. (L) amazonenses expressoras de luciferase e caracterizar o comportamento das

APA, Harvard, Vancouver, ISO, and other styles

23

Curry, Stephen. "The interactions of general anaesthetics with a bacterial luciferase enzyme." Thesis, Imperial College London, 1989. http://hdl.handle.net/10044/1/47396.

Full text

APA, Harvard, Vancouver, ISO, and other styles

24

Stowe, Cassandra. "Development of firefly luciferase bioluminescence for in vivo optical imaging." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10041771/.

Full text

Abstract:

Firefly luciferase is ubiquitously used as a genetic reporter for the non-invasive bioluminescence imaging of small animal models. This widespread use of Firefly luciferase in vivo has been facilitated by genetic engineering producing mutants which are extremely stable at physiological conditions. In addition, the red-shifting of bioluminescence has resulted in the enhanced penetration of light emission through biological tissue. However, the use of bioluminescence in vivo is still largely limited to the tracking of single events within a model. This is due to the differential attenuation of l

APA, Harvard, Vancouver, ISO, and other styles

25

Falklöf, Olle. "Photochemical properties of phytochrome and firefly luciferase chromophores: A theoretical study." Licentiate thesis, Linköpings universitet, Beräkningsfysik, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-103338.

Full text

Abstract:

This licentiate thesis presents computational chemistry studies on photochemical properties of phytochrome and firefly luciferase chromophores. Phytochromes are bilin-containing proteins that based on the ambient light environment regulate a number of physiological and developmental processes in bacteria, cyanobacteria, fungi and plants. From the viewpoint of computational modeling, however, only a few studies have been devoted to these systems. In this thesis, two systematic studies comparing calculated and experimental UV-vis spectra of bilin chromophores in protein and solution environments

APA, Harvard, Vancouver, ISO, and other styles

26

Moss, Guy William John. "The interactions of general anaesthetics and high pressure with firefly luciferase." Thesis, Imperial College London, 1989. http://hdl.handle.net/10044/1/47575.

Full text

APA, Harvard, Vancouver, ISO, and other styles

27

Law, Gim Hoong Erica. "Mutational analysis of solvent-exposed amino acids in Photinus pyralis luciferase." Thesis, University of Cambridge, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.615816.

Full text

APA, Harvard, Vancouver, ISO, and other styles

28

Halliwell, Lisa Marie. "Protein engineering utilising single amino acid deletions within Photinus pyralis firefly luciferase." Thesis, Cardiff University, 2015. http://orca.cf.ac.uk/89475/.

Full text

Abstract:

The bioluminescence reaction is catalysed by firefly luciferase, converting the substrates D-luciferin, ATP and molecular oxygen with Mg2+ to produce light and this reaction has had wide ranging implications within a number of fields from industry to academia. The discovery of luciferase has been revolutionary in the real time in vivo study of cells given that it requires no energy for excitation, delivering a high signal to background ratio providing a highly sensitive assay. This protein, to date, has been utilised in molecular cell biology, cellular imaging, microbiology and numerous other

APA, Harvard, Vancouver, ISO, and other styles

29

Lake, Madryn. "Non-invasive imaging of estrogen receptor-coregulator interaction by luciferase fragment complementation." Thesis, Imperial College London, 2012. http://hdl.handle.net/10044/1/9256.

Full text

Abstract:

Breast cancer is the most common cancer in the UK and approximately 1 in 8 women will be affected by the disease. Estrogen regulates breast cancer growth through the action of the estrogen receptors ERα and ERβ. Antiestrogens, in particular tamoxifen, have contributed greatly to the reduction in breast cancer mortality. Tamoxifen is a tissue selective antiestrogen; it is antiestrogenic in the breast but estrogenic in other tissues, thereby enabling it to promote the beneficial effects of estrogen, such as maintaining bone density. However, like estrogen, tamoxifen also promotes endometrial can

APA, Harvard, Vancouver, ISO, and other styles

30

Mok, Pui-Wing. "Design and Applications of Split-Luciferase Systems in Vitro and in Cellulo." Diss., The University of Arizona, 2014. http://hdl.handle.net/10150/333354.

Full text

Abstract:

Split-protein reassembly methods allow for the detection of a variety of macromolecular interactions in vitro, in cellulo and in vivo. Spilt-protein reporters, such as split-firefly luciferase (Fluc), depend upon the conditional reassembly of the genetically fragmented enzyme. The two fragments of Fluc conditionally reassemble and regain activity when protein domains appended to the N-terminal and C-terminal Fluc fragments interact. Our laboratory has previously reported the use of the split-Fluc system in the detection of protein-protein, protein-nucleic acid, and protein-small molecule inter

APA, Harvard, Vancouver, ISO, and other styles

31

Scott, Mark George Hunter. "Control of cyclic AMP-mediated and ÃŸâ‚‚ adrenergic receptor gene expression in cultured human airway smooth muscle cells." Thesis, University of Nottingham, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.324123.

Full text

APA, Harvard, Vancouver, ISO, and other styles

32

Kemp, Daniel M. "Reporter gene analysis of regulatory mechanisms in cAMP signalling." Thesis, University of Kent, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.310202.

Full text

APA, Harvard, Vancouver, ISO, and other styles

33

Mackay, Daniel. "Advertising the soul : Walt Whitman's luciferic voice in twentieth-century American poetry /." Connect to title online (ProQuest), 2008. http://proquest.umi.com/pqdweb?did=1594829931&sid=2&Fmt=2&clientId=11238&RQT=309&VName=PQD.

Full text

APA, Harvard, Vancouver, ISO, and other styles

34

Hildebrandt, Stefanie. "Etablierung des Luciferase-Reportergenassays zur Quantifizierung der Bioaktivität von Leptin in menschlichem Serum." Doctoral thesis, Universitätsbibliothek Leipzig, 2013. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-113565.

Full text

Abstract:

Vor dem Hintergrund der zunehmenden Prävalenz von Adipositas ist die Erforschung der zugrunde liegenden Pathomechanismen, unter anderem der Leptinresistenz, von großer Bedeutung. Der Schwerpunkt der vorliegenden Arbeit lag in der Etablierung und Validierung einer Methode zur Bestimmung der Bioaktivität von Leptin in Serum. Aufgrund des Vorhandenseins von Leptinbindungsproteinen erscheint nur der Teil des Serumleptins funktionell entscheiden, der tatsächlich den Leptinrezeptor erreicht und eine Bioantwort im Sinne einer Gewichtsreduktion auszulösen vermag. Der Bioassay basiert auf der Nutzung v

APA, Harvard, Vancouver, ISO, and other styles

35

Gupta, Rajat [Verfasser], and Ulrich [Akademischer Betreuer] Hartl. "Firefly luciferase mutants as sensors of proteome stress / Rajat Gupta. Betreuer: Ulrich Hartl." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2012. http://d-nb.info/1028191898/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

36

Murray, Shane Louise. "Identification and characterisation of Arabidopsis systemic acquired resistance mutants isolated by luciferase imaging." Thesis, University of Edinburgh, 2000. http://hdl.handle.net/1842/11207.

Full text

Abstract:

Plants have evolved a complex series of integrated defence mechanisms against pathogens. Following recognition of a pathogen avirulence (<i>avr)</i> gene product by the corresponding plant resistance (<i>R)</i> gene product, a complex signalling network is initiated. Local inducible defences are activated and a long-distance signal is released, leading to the establishment of systemic acquired resistance (SAR) to a wide range of pathogens. SAR is marked by the accumulation of pathogenesis-related (PR) proteins. Salicylic acid (SA) is a key signalling molecule in SAR, inducing <i>PR</i> gene ex

APA, Harvard, Vancouver, ISO, and other styles

37

Jester, Benjamin. "Development of a Three-Hybrid Split-Luciferase System for Interrogating Protein Kinase Inhibition." Diss., The University of Arizona, 2011. http://hdl.handle.net/10150/205450.

Full text

Abstract:

Eukaryotic protein kinases are one of the most important classes of human proteins, and a great deal of research has focused on the development of small molecule inhibitors as biological probes for the determination of their cellular function or as therapeutics for the treatment of disease, such as cancer. The need for new selective inhibitors and a better understanding of the selectivities of existing small molecules is readily apparent. Towards the goal of better understanding protein kinases and the molecules that inhibit them, I have developed a split-protein-based approach for the invest

APA, Harvard, Vancouver, ISO, and other styles

38

Waldenmaier, Hans Eugene. "Bioluminescência fúngica: papel ecológico, purificação e clonagem de enzimas." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-14072017-145527/.

Full text

Abstract:

Esta tese de doutorado descreve os estudos realizados para elucidar a biologia molecular da bioluminescência fúngica e sua relevância ecológica na natureza. A recente descoberta de que a luciferina fúngica é a 3-hidroxihispidina permitiu a caracterização do metabolismo secundário da fenilalanina nos genomas recém-sequenciados e transcriptomas de micélios das espécies luminescentes Panellus stipticus e Neonothopanus gardneri. Adicionalmente os genomas e transcriptomas de variedades não luminescente de P. stipticus e Lentinula edodes serviram como respectivos controles. Em geral, os genes envolv

APA, Harvard, Vancouver, ISO, and other styles

39

Maiwald, Gelja. "In vivo bioluminescence imaging for monitoring of siRNA mediated luciferase knockdown in tumor models." kostenfrei, 2009. http://d-nb.info/1001449320/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

40

Maiwald, Gelja. "In vivo bioluminescence imaging for monitoring of siRNA mediated luciferase knockdown in tumor models." Diss., lmu, 2010. http://nbn-resolving.de/urn:nbn:de:bvb:19-113028.

Full text

APA, Harvard, Vancouver, ISO, and other styles

41

Wiencierz, Anne Maria. "Entwicklung eines Dual-Luciferase-Reportergen-Assays zum Nachweis der Induktion antioxidativer Enzyme durch Nahrungsbestandteile." Master's thesis, Universität Potsdam, 2008. http://opus.kobv.de/ubp/volltexte/2009/2790/.

Full text

Abstract:

Die Induktion antioxidativer Enzyme gilt als eine Möglichkeit, die antioxidative Kapazität von Zellen zu steigern und dadurch mit oxidativem Stress assoziierten Erkrankungen (z. B. Herz-Kreislauf-Erkrankungen, Neurodegeneration, Atherosklerose) vorzubeugen. Ausgehend davon wurde in der vorliegenden Arbeit der Dual-Luciferase-Reportergen-(DLR)-Assay zum Nachweis der Induktion der antioxidativen Enzyme Katalase (CAT), zytosolische Glutathion-Peroxidase (GPX1) und Kupfer-Zink-Superoxid-Dismutase (SOD1) entwickelt. Im Zuge dessen wurden drei Säugetierzelllinien (CaCo2, IEC-18, V79) auf ihre Eignun

APA, Harvard, Vancouver, ISO, and other styles

42

Cowan, Heather Elizabeth. "Rapid, Quantitative Assessment of Antimycobacterial Water Disinfection based on the Firefly Luciferase Reporter Gene." Thesis, Virginia Tech, 1997. http://hdl.handle.net/10919/9748.

Full text

Abstract:

Mycobacterium avium causes disseminated infection in humans with immunodeficiency, pulmonary infections in individuals with predisposing lung conditions (e.g., pneumoconiosis), and cervical lymphadenitis in children. Twenty-five to fifty percent of late stage AIDS patients are infected with M. avium. M. avium has been recovered from drinking water and strains from water share identical DNA fingerprints with isolates recovered from patients exposed to the water. Further, M. avium is resistant to chlorine, a disinfectant commonly used in municipal water supplies. Because of the slow growth of M.

APA, Harvard, Vancouver, ISO, and other styles

43

Farkašová, Katarina [Verfasser], and Eckhard [Akademischer Betreuer] Wolf. "Bioluminescence imaging of luciferase transgenes in tumor metastases models / Katarína Farkašová. Betreuer: Eckhard Wolf." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2011. http://d-nb.info/1019479302/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

44

Erber, Astrid Maria [Verfasser], and Andreas [Akademischer Betreuer] Bechthold. "Untersuchungen zu Luciferase-ähnlichen Monooxygenasen, Flavinreduktasen und Ketoreduktasen aus dem Mensacarcin-Produzenten Streptomyces bottropensis." Freiburg : Universität, 2017. http://d-nb.info/1135572178/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

45

Temperley, Richard James. "Generation of a reporter for mitochondrial gene expression studies." Thesis, University of Newcastle Upon Tyne, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.369782.

Full text

APA, Harvard, Vancouver, ISO, and other styles

46

Campbell, Zachary Taylor. "STUDIES ON THE MECHANISM OF BACTERIAL BIOLUMINESCENCE IN VIVO AND IN VITRO." Diss., The University of Arizona, 2009. http://hdl.handle.net/10150/195376.

Full text

Abstract:

Despite the importance of molecular recognition in nearly all aspects of protein function, the determinants of specificity for enzyme-substrate and protein-protein interactions are poorly understood. The majority of these complexes involving bacterial luciferase from V. harveyi have yet to be fully characterized. Luciferase catalyzes the reaction of molecular oxygen, FMNH2 and a long-chain aliphatic aldehyde yielding FMN, the corresponding carboxylic acid and blue-green light. In vivo, luciferase is thought to obtain FMNH2 following transfer from a transiently associated oxidoreductase. To

APA, Harvard, Vancouver, ISO, and other styles

47

Adams, Spencer T. Jr. "Deconstructing bioluminescence: from molecular detail to in vivo imaging." eScholarship@UMMS, 2020. https://escholarship.umassmed.edu/gsbs_diss/1064.

Full text

Abstract:

Bioluminescence is the chemical production of light that results when a luciferase enzyme catalyzes the luminogenic oxidation of a small-molecule luciferin substrate. The numerous luciferases and luciferins nature has evolved can be used to illuminate biological processes, from in vitro assays to imaging processes in live animals. However, we can improve the utility of bioluminescence through modification of these enzymes and substrates. My thesis work focuses on developing reporters that expand the bioluminescent toolkit and improving our understanding of how bioluminescence works on a molecu

APA, Harvard, Vancouver, ISO, and other styles

48

Cabral, Priscilla Carvalho. "Desenvolvimento de modelo experimental murino para o estudo da imunobiologia do melanoma." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/42/42133/tde-16112016-093857/.

Full text

Abstract:

O câncer compreende uma doença multifatorial responsável por altíssimos indíces de mortalidade globalmente. Embora atualmente tenhamos resultados positivos em relação ao tratamento do câncer principalmente voltados à imunoterapia, dados alarmantes ainda são encontrados. Assim, desenvolvemos linhagens tumorais geneticamente modificadas para expressarem ovalbumina (mOVA ou cOVA) e luciferase, a fim de estudarmos as interações do sistema imune com o tumor. Em nossos resultados, a presença da ovalbumina indicou: Alteração no perfil de crescimento tumoral em animais previamente imunizados com OVA

APA, Harvard, Vancouver, ISO, and other styles

49

Gouilleux, Fabrice. "Facteurs impliques dans la regulation du promoteur du virus murin de la tumeur mammaire." Paris 11, 1991. http://www.theses.fr/1991PA115005.

Full text

APA, Harvard, Vancouver, ISO, and other styles

50

Roy, Karine. "Etude de la physiologie de Lactococcus lactis implanté dans le tractus digestif de souris par une approche protéomique." Paris 11, 2007. http://www.theses.fr/2007PA112050.

Full text

Abstract:

La colonisation du tractus digestif (TD) par une bactérie requiert un ensemble de fonctions qu’il est important de connaître pour comprendre le fonctionnement de cet écosystème. Dans ce travail, nous avons étudié l’adaptation de Lactococcus lactis à l’environnement digestif. L. Lactis est un levain de l'industrie laitière et les développements récents ont démontré son potentiel comme vecteur pour délivrer des molécules à visée médicale. L’adaptation au TD a été étudiée sur des souris monoxéniques pour L lactis par une approche protéomique. L. Lactis s’établit à une population équivalente à cel

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!