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Journal articles on the topic 'Lugol's iodine'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Tsurumaru, Daisuke, Takashi Utsunomiya, Shuji Matsuura, et al. "Gastric Mucosal Changes Caused by Lugol's Iodine Solution Spray: Endoscopic Features of 64 Cases on Screening Esophagogastroduodenoscopy." Gastroenterology Research and Practice 2010 (2010): 1–4. http://dx.doi.org/10.1155/2010/494195.

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Aim. To clarify the endoscopic mucosal change of the stomach caused by Lugol's iodine solution spray on screening esophagogastroduodenoscopy (EGD).Methods. Sixty-four consecutive patients who underwent EGD for esophageal squamous cell carcinoma screening were included in this study. The records for these patients included gastric mucosa findings before and after Lugol's iodine solution was sprayed. The endoscopic findings of the greater curvature of the gastric body were retrospectively analyzed based on the following findings: fold thickening, exudates, ulcers, and hemorrhage.Results. Mucosal

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2

Shanmugam, Subbiah, and Sathiyaseelan Balakrishnan. "Utility of Lugol’s iodine in assessing the margin status of early stage oral cavity cancer-could it be a simple and effective way to achieve R0 resection?" International Journal of Otorhinolaryngology and Head and Neck Surgery 10, no. 1 (2024): 35–39. http://dx.doi.org/10.18203/issn.2454-5929.ijohns20240055.

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Background: It is often challenging to distinguish between dysplastic and normal mucosa during surgery. Use of staining agents that will identify abnormal mucosa may improve results. Because Lugol's iodine is readily available, simple to use, and cost-effective, it was chosen as the preferred staining agent. To determine the effectiveness of Lugol’s iodine application in achieving R0 resection in early-stage oral cavity malignancy and thereby leading to better outcomes after treatment. Methods: In this study we included 49 patients and randomized them into two arms. One arm we did wide excisio

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3

Reddy, Ashwini C., and Mayilvaganan Sabaretnam. "Lugol's iodine in Graves' disease – Revisited." International Journal of Surgery 36 (December 2016): 30–31. http://dx.doi.org/10.1016/j.ijsu.2016.10.018.

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4

Pinilla, Juan Carlos, Andrea Isabel Pinilla, and Angel Alberto Florez. "Comparison between five coprological methods for the diagnosis of Balantidium coli cysts in fecal samples from pigs." Veterinary World 14, no. 4 (2021): 873–77. http://dx.doi.org/10.14202/vetworld.2021.873-877.

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Background and Aim: Balantidium coli is a protozoan that can infect humans and non-human primates, being the domestic pigs the animals most affected by this parasite. This study aimed to compare the performance of five coprological methods for diagnosis of Balantidium coli cysts in fecal samples from pigs. Materials and Methods: From September to December 2019, 558 fecal samples were collected from the rectum of backyard pigs in the Bucaramanga metropolitan area, Colombia. The average age of the sampled animals was 3-4 months. Fecal samples collected were tested using the following coprologica

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5

Jaju, Prashant, and Sushma Jaju. "Lugol's iodine: potential use in invasive carcinoma." British Journal of Oral and Maxillofacial Surgery 49, no. 4 (2011): 327. http://dx.doi.org/10.1016/j.bjoms.2011.01.002.

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6

McCaul, James Anthony, Jeremy McMahon McMahon, Jacqueline Quantrill, et al. "LIHNCS: Lugol’s Iodine in Head and Neck Cancer Surgery—A multi-centre, randomised, controlled trial assessing the effectiveness of Lugol’s Iodine to assist excision of moderate dysplasia, severe dysplasia and carcinoma in-situ at mucosal resection margin of oral and oropharyngeal squamous cell carcinoma." Journal of Clinical Oncology 35, no. 15_suppl (2017): 6065. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.6065.

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6065 Background: Oral cavity and oropharynx cancer are increasing worldwide but survival has not significantly improved over the last thirty years. Presence of dysplasia or carcinoma in-situ at surgical margins following resection of squamous carcinoma (SCC) of the head and neck is associated with increased local recurrence and reduced survival. While carcinoma can usually be distinguished from normal mucosa, dysplasia is less readily distinguished at operation. We describe outcomes of LIHNCS, a RCT assessing effectiveness of Lugol’s iodine staining for visualization and excision of margin dys

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7

Waqas Iqbal, Talha Asad Khan, Khushbu Lohana, and Hafiz Mehmood. "Lugol's iodine and methylene blue as an adjunctive tool for early diagnosis of premalignant oral lesions." Professional Medical Journal 30, no. 06 (2023): 785–90. http://dx.doi.org/10.29309/tpmj/2023.30.06.7270.

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Objective: To compare Lugol’s Iodine and Methylene blue as an adjunctive tool for early diagnosis of premalignant oral lesions by taking histopathology as the gold standard. Study Design: Cross-sectional descriptive. Setting: Outpatient Department of Isra Dental College Hospital, Isra University Hyderabad. Period: January 2021 to July 2021. Material & Methods: All patients with oral premalignant lesions were selected. Methylene blue and iodine staining were used in the lesion area. The dye was applied directly with a cotton bud for 10–20 seconds, and the mouth was resigned with tap water.

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8

Komínek, Pavel, Petr Vítek, Ondřej Urban, et al. "Chromoendoscopy to Detect Early Synchronous Second Primary Esophageal Carcinoma in Patients with Squamous Cell Carcinomas of the Head and Neck?" Gastroenterology Research and Practice 2013 (2013): 1–5. http://dx.doi.org/10.1155/2013/236264.

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Objective. To evaluate the use of flexible esophagoscopy and chromoendoscopy with Lugol’s solution in the detection of early esophageal carcinomas (second primary carcinomas) in patients with squamous cell carcinoma of the head and neck (HNSCC).Methods. All patients with newly diagnosed HNSCC underwent office-based Lugol's chromoendoscopy. After flexible esophagoscopy with white light, 3.0% Lugol's iodine solution was sprayed over the entire esophageal mucosa. Areas with less-intense staining (LVLs) were evaluated and biopsies taken.Results. 132 patients with HNSCC were enrolled in this study.

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9

Kanatas, A., G. W. Jenkins, D. N. Sutton, and J. A. McCaul. "65 Lugol's iodine detection of synchronous primary mucosal cancer." British Journal of Oral and Maxillofacial Surgery 48 (May 2010): S17. http://dx.doi.org/10.1016/s0266-4356(10)60066-6.

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10

Wit, J. M., L. J. Gerards, C. Vermeulen-Meiners, and H. W. Bruinse. "Neonatal thyrotoxicosis treated with exchange transfusion and Lugol's iodine." European Journal of Pediatrics 143, no. 4 (1985): 317–19. http://dx.doi.org/10.1007/bf00442312.

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11

Jamieson, A., and C. G. Semple. "Successful Treatment of Graves Disease in Pregnancy with Lugol's Iodine." Scottish Medical Journal 45, no. 1 (2000): 20–21. http://dx.doi.org/10.1177/003693300004500107.

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We report a case of Grave's disease in pregnancy complicated by intolerance of standard antithyroid drug therapy. We describe the success of prolonged use of organic iodine as a primary treatment prior to surgical intervention.

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12

Durdi, Geeta, Kamal Patil, and Lakshita Lumb. "Evaluation of Downstaging, Visual Inspection with Acetic Acid and Lugol's Iodine in Screening of Cervical Cancer." Journal of South Asian Federation of Obstetrics and Gynaecology 3, no. 2 (2011): 63–66. http://dx.doi.org/10.5005/jp-journals-10006-1130.

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ABSTRACT Objectives To detect and compare the sensitivity and specificity of downstaging and visual inspection with acetic acid (VIA) and with Lugol's iodine (VILI). Methods Screening with downstaging, VIA and VILI were done on 680 women who fulfilled the inclusion criteria at a primary health center attached to the university hospital, over a period of one year. Those who had abnormal results in downstaging, VIA and VILI were biopsied and sensitivity, specificity, negative predictive value and positive predictive value were calculated. Results The sensitivities of downstaging, VIA and VILI we

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13

Dunn, Janet A., Raghav Kulkarni, David Gouldesbrough, et al. "LIHNCS trial: Lugol's iodine in head and neck cancer surgery." Journal of Clinical Oncology 30, no. 15_suppl (2012): e16042-e16042. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.e16042.

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e16042 Background: Residual dysplasia at margins of mucosal tumour resection is a cause of disease failure. While risk of transformation of dysplasia is difficult to assess, malignant cells within a field of dysplastic change indicate high transformation potential of this dysplastic field. Lugol's iodine assists in the assessment of surgical margins at tumour resection to ensure removal of margin dysplasia where present and resectable using the surrogate biomarker of glycogen storage. This multicenter RCT assesses efficacy of this technique in head and neck cancer surgery and is recruiting ove

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14

Hawkins, Peter R., Jon Holliday, Amrit Kathuria, and Lee Bowling. "Change in cyanobacterial biovolume due to preservation by Lugol's Iodine." Harmful Algae 4, no. 6 (2005): 1033–43. http://dx.doi.org/10.1016/j.hal.2005.03.001.

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15

Basu, Rajarshi, Shereen Fatima, and NeelakamalH Hallur. "Lugol's iodine identifies dysplastic tissue in precancerous lesions: A clinical trial." Annals of Maxillofacial Surgery 6, no. 2 (2016): 172. http://dx.doi.org/10.4103/2231-0746.200333.

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16

Janmohamed, T., K. Ali, A. Hassen, and A. Gupta. "Use of Lugol's Iodine as a Tool for Preliminary Oral Biopsies." International Journal of Oral and Maxillofacial Surgery 53 (November 2024): 2–3. http://dx.doi.org/10.1016/j.ijom.2024.08.008.

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17

Kidwell, JA, DE Fleischer, GQ Wang, RM Anderson, B. Zhou, and SM Dawsey. "Mucosal staining of the esophagus with lugol's iodine solution: Technical aspects." Gastrointestinal Endoscopy 41, no. 4 (1995): 352. http://dx.doi.org/10.1016/s0016-5107(05)80263-9.

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18

Kanatas, A. N., G. W. Jenkins, D. Sutton, and J. A. McCaul. "Lugol's iodine identifies synchronous invasive carcinoma—time for a clinical trial." British Journal of Oral and Maxillofacial Surgery 49, no. 5 (2011): 409–11. http://dx.doi.org/10.1016/j.bjoms.2010.07.013.

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19

Kanash, Sunita, S. D. Shirodkar, and Swati Gawai. "A study of visual inspection of cervix under acetic acid and visual inspection of cervix under Lugol's iodine for screening of carcinoma cervix." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 8, no. 9 (2019): 3505. http://dx.doi.org/10.18203/2320-1770.ijrcog20193665.

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Background: Carcinoma cervix is the most common cancer among women in developing countries. The objectives of the study were to study the sensitivity and specificity of visual inspection of the cervix with acetic acid (VIA) and Lugol's iodine (VILI) for cervical cancer screening. To study the correlation of demographic data like age, socioeconomic status, education residential area, parity, age at marriage in premalignant lesion of the cervix.Methods: The present study was conducted in the department of Obstetrics and Gynecology at a Tertiary Medical Care Center over a period of two years. Fiv

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20

Sreedharan, A. "Acute toxic gastric mucosal damage induced by Lugol's iodine spray during chromoendoscopy." Gut 54, no. 6 (2005): 886–87. http://dx.doi.org/10.1136/gut.2004.061739.

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21

Zinabu, G. M., and Thomas L. Bott. "The effects of formalin and Lugol's iodine solution on protozoal cell volume." Limnologica - Ecology and Management of Inland Waters 30, no. 1 (2000): 59–63. http://dx.doi.org/10.1016/s0075-9511(00)80044-4.

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22

Marigold, J. H., A. K. Morgan, D. J. Earle, A. E. Young, and D. N. Croft. "Lugol's iodine: Its effect on thyroid blood flow in patients with thyrotoxicosis." British Journal of Surgery 72, no. 1 (1985): 45–47. http://dx.doi.org/10.1002/bjs.1800720118.

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23

Rösner, Harald, Wolfgang Möller, Sabine Groebner, and Pompilio Torremante. "Antiproliferative/cytotoxic effects of molecular iodine, povidone-iodine and Lugol's solution in different human carcinoma cell lines." Oncology Letters 12, no. 3 (2016): 2159–62. http://dx.doi.org/10.3892/ol.2016.4811.

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24

Karacalı Tunç, Ayşe, Büşra Merve Sarıtaş, Mahdi Marzi, Feray Şenel Dursun, and Şevin Kaya. "Antimicrobial Effect of Drinkable Lugol Solution." Journal of the Institute of Science and Technology 14, no. 4 (2024): 1432–37. http://dx.doi.org/10.21597/jist.1521217.

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The death rates due to infection in patients receiving long-term antibiotic treatment and hospitalized patients are quite alarming. Treatment of multidrug-resistant strains of Acinetobacter baumannii, Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus, which cause widespread nosocomial infection, has become a global problem. Alternative treatment methods are needed for these species, which use all their resistance mechanisms day by day. Recently, it has been seen that iodine (lugol) solution has been used in the treatment of many infections. Significant r

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25

Al-Salihi, Siham S., and Israa A. M. Jumaah. "Activity of Some Disinfectants, Detergents and Essential Oils on Growth of the yeast Candida albicans." Al-Mustansiriyah Journal of Science 28, no. 1 (2017): 25. http://dx.doi.org/10.23851/mjs.v28i1.308.

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The study was conducted for estimating antifungal activity against Candida albicans of ten essential oil, garlic and onion juice, eight disinfectants and detergents by using agar diffusion well method.  The results showed high activity of clove oil, onion juice 50%, thyme oil, hydrogen peroxide (H2O2), lugol's iodine and detol for all the five concentration, sodium chloride (NaCl) and sodium carbonate (Na2CO3) at 5%, while the effect of apple cider vinegar were at 60% and 80%. Sodium hypochlorite showed moderate activity at all concentration. The result of combination between clove oil a

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26

Basford, Peter John, Anna Benton, Tracie Jarvis, and Pradeep Bhandari. "Indigo carmine or Lugol's iodine? A beginner's guide to chromoendoscopy and advanced imaging." Gastrointestinal Nursing 11, no. 6 (2013): 16–23. http://dx.doi.org/10.12968/gasn.2013.11.6.16.

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27

Dawsey, SM, GQ Wang, JA Kidwell, B. Zhou, and DE Fleischer. "Esophageal staining with lugol's iodine identifies additional lesions in high-risk chinese patients." Gastrointestinal Endoscopy 41, no. 4 (1995): 347. http://dx.doi.org/10.1016/s0016-5107(05)80241-x.

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28

Yilmaz, Yeliz, Kemal Erdinc Kamer, Orhan Ureyen, Erdem Sari, Turan Acar, and Onder Karahalli. "The effect of preoperative Lugol's iodine on intraoperative bleeding in patients with hyperthyroidism." Annals of Medicine and Surgery 9 (August 2016): 53–57. http://dx.doi.org/10.1016/j.amsu.2016.06.002.

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29

Kiernan, John A. "A Hint for Fixing Tissues for Better Staining." Microscopy Today 7, no. 1 (1999): 21. http://dx.doi.org/10.1017/s155192950006380x.

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For beautiful colors in near perfectly preserved cells and connective tissue, immerse carefully cut pieces, no more than 2 mm in least dimension, overnight in either Heidenhain's SUSA or Helly's fluid or Zenker's fluid without the acetic acid (which is the same as Helly's without the formalin). Wash thoroughly in water (tap water is OK) for several hours (overnight is sensible) and then dehydrate, clear, infiltrate, embed and cut paraffin sections.After dewaxing and hydrating the slides, put them in an iodine solution (Lugol's, Gram's or 0.5% I2 in 95% ethanol), then in sodium thiosuifate (2-6

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30

Rahman, Md Nafiur, Mohammad Abdullah-Al-Shoeb, Saaimatul Huq, and Muhammad Abul Kalam Azad. "Assessment of antibacterial efficacy of Lugol's iodine compared with commercial hand sanitizers of Bangladesh." Journal of World's Poultry Research 9, no. 5 (2019): 130–37. http://dx.doi.org/10.36380/scil.2019.jlsb21.

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31

McMahon, Jeremy, John C. Devine, James A. McCaul, Douglas R. McLellan, and Adrian Farrow. "Use of Lugol's iodine in the resection of oral and oropharyngeal squamous cell carcinoma." British Journal of Oral and Maxillofacial Surgery 48, no. 2 (2010): 84–87. http://dx.doi.org/10.1016/j.bjoms.2009.05.007.

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32

McCaul, James Anthony, D. N. Sutton, J. C. Devine, et al. "Randomised controlled trial of Lugol's iodine in head and neck cancer surgery (LIHNCS trial)." British Journal of Oral and Maxillofacial Surgery 47, no. 7 (2009): e52. http://dx.doi.org/10.1016/j.bjoms.2009.06.077.

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33

McCaul, James Anthony, James Cymerman, David N. Sutton, et al. "Feasibility and surgeon acceptability of visualisation with Lugol's iodine (VILI) in the LIHNCS trial." British Journal of Oral and Maxillofacial Surgery 51, no. 6 (2013): e91-e92. http://dx.doi.org/10.1016/j.bjoms.2013.05.044.

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34

Khine, Aye, and Ngwe Yin. "LBODP104 Thyroid Plasmapheresis: An Alternative Option For Thyroid Storm." Journal of the Endocrine Society 6, Supplement_1 (2022): A743. http://dx.doi.org/10.1210/jendso/bvac150.1533.

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Abstract Introduction Thyroid storm is a rare, life-threatening condition with a high mortality rate approaching 10-30%. The mainstay of treatment includes initiation of therapy directed against the thyroid, supportive intensive care, and treatment of any precipitating factors. We report three cases of patients with thyroid storm and successful therapeutic use of plasmapheresis when traditional therapy was contraindicated. Clinical Cases Case 1 A 22-year-old male with no known past medical history, presented with fever, shortness of breath, and syncope. Labs showed TSH 0. 014 mIU/L (range 0.4-

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35

Gursoy, Ali. "Efficacy of Acetic Acid and Lugol's Iodine Assisted Colposcopic Imaging in Cases with Anormal Pap Smear Test Results." Chronicles of Precision Medical Researchers 4, no. 1 (2023): 91–95. https://doi.org/10.5281/zenodo.7709009.

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Aim: This study was conducted to investigate the diagnostic efficacy of colposcopic imaging with Acetic Acid and Lugol’s Iodine in cases with abnormal pap smear test results. Material and Method: Hundred and five patients who presented to the Maltepe University Medical Faculty Hospital Gynecology Outpatient Clinic between 2017 and 2020 with abnormal pap smear results and whose biopsy was taken using colposcopic imaging were evaluated retrospectively. The study included patients with Pap smear results indicating atypical squamous cells of undetermined significance (ASCUS), low grade squam

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36

McMahon, Jeremy, J. Devine, J. McCaul, D. McLellan, and G. Bryson. "The use of Lugol's Iodine in the resection of oral and oropharyngeal squamous cell carcinoma." British Journal of Oral and Maxillofacial Surgery 45, no. 7 (2007): e59. http://dx.doi.org/10.1016/j.bjoms.2007.07.089.

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37

Hausmann, R., C. Pregler, and B. Schellmann. "The value of the Lugol's iodine staining technique for the identification of vaginal epithelial cells." International Journal of Legal Medicine 106, no. 6 (1994): 298–301. http://dx.doi.org/10.1007/bf01224775.

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38

Peng, Guiyong, Qinglin Long, Yuwei Wu, Jingjing Zhao, Lei Chen, and Xianghong Li. "Evaluation of double vital staining with lugol's iodine and methylene blue in diagnosing superficial esophageal lesions." Scandinavian Journal of Gastroenterology 46, no. 4 (2010): 406–13. http://dx.doi.org/10.3109/00365521.2010.545829.

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39

McMahon, J., J. Devine, J. McCaul, D. Mclellan, and G. Bryson. "P39 The use of Lugol's Iodine in the resection of oral and oropharyngeal squamous cell carcinoma." Oral Oncology Supplement 2, no. 1 (2007): 143. http://dx.doi.org/10.1016/s1744-7895(07)70317-6.

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40

Russo, Evandro, Emil Kupek, and Rita Maria Zanine. "High grade CIN diagnosis by combined visual inspection with Lugol's iodine and cytology in symptomatic women." European Journal of Obstetrics & Gynecology and Reproductive Biology 156, no. 1 (2011): 91–95. http://dx.doi.org/10.1016/j.ejogrb.2010.12.022.

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41

Zibaei, Mohammad, Farzaneh Firoozeh, and Alireza Azargoon. "Infantile Amoebiasis: A Case Report." Case Reports in Infectious Diseases 2012 (2012): 1–3. http://dx.doi.org/10.1155/2012/614398.

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Amoebiasis continues to be a major cause of morbidity and mortality in children in developing countries.Entamoeba histolyticainfections are commonly observed in tropical and subtropical regions of the world including Iran. In developed countriesEntamoeba histolyticainfections are commonly seen in travelers, recent immigrants, homosexual men, and inmates of institutions. The disease is more severe in the two extremes of life. This paper paper describes a four-month-old male infant withEntamoeba histolyticapresenting initially with refusal of feeds, hyperactive bowel sound, vomiting, and diarrhe

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Pasvan, Chandrakant, Ashok Dongol, Pradeep Acharya, et al. "P-138 Comparison between Lugol's iodine and Autofluorescence imaging to determine margin of oral squamous cell carcinoma." Oral Oncology 118 (July 2021): 8. http://dx.doi.org/10.1016/s1368-8375(21)00425-5.

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43

Konidena, Aravinda, Dheeraj Sharma, and Alpna Sharma. "Diagnostic efficiency of methylene blue and lugol's iodine double staining method in oral leukoplakia in detecting dysplasia." Indian Journal of Dental Research 32, no. 3 (2021): 310. http://dx.doi.org/10.4103/ijdr.ijdr_291_19.

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44

Qiao, Liang, Bo Li, Mei Long, Xiao Wang, Anrong Wang, and Guonan Zhang. "Accuracy of visual inspection with acetic acid and with Lugol's iodine for cervical cancer screening: Meta-analysis." Journal of Obstetrics and Gynaecology Research 41, no. 9 (2015): 1313–25. http://dx.doi.org/10.1111/jog.12732.

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45

Nakanishi, Yukihiro, Atsushi Ochiai, Kimio Yoshimura, et al. "The clinicopathologic significance of small areas unstained by lugol's iodine in the mucosa surrounding resected esophageal carcinoma." Cancer 82, no. 8 (1998): 1454–59. http://dx.doi.org/10.1002/(sici)1097-0142(19980415)82:8<1454::aid-cncr4>3.0.co;2-9.

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46

Auinger, Barbara M., Karin Pfandl, and Jens Boenigk. "Improved Methodology for Identification of Protists and Microalgae from Plankton Samples Preserved in Lugol's Iodine Solution: Combining Microscopic Analysis with Single-Cell PCR." Applied and Environmental Microbiology 74, no. 8 (2008): 2505–10. http://dx.doi.org/10.1128/aem.01803-07.

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ABSTRACT Here we introduce a method for quantitative analysis of planktonic protists and microalgae from preserved field samples combining morphological and small-subunit (SSU) rRNA gene sequence analysis. We linked a microscopic screening with PCR of single cells using field samples preserved with Lugol's iodine solution. Cells possessing a rigid cell wall were incubated with Viscozyme and subsequently with proteinase K for cell disruption; this was unnecessary for fragile cells. The addition of sodium thiosulfate to the PCR tube considerably decreased the inhibiting effect of the fixative (i

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47

Tsuji, Naoko, Shingo Ishiguro, and Masatoshi Kudo. "Esophagus with multiple small Lugol's iodine-unstained lesions has high likelihood of developing multicentric esophageal squamous cell carcinoma." Gastroenterology 124, no. 4 (2003): A298. http://dx.doi.org/10.1016/s0016-5085(03)81502-0.

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48

Busingye, Priscilla, Annettee Nakimuli, Evelyn Nabunya, and Twaha Mutyaba. "Acceptability of cervical cancer screening via visual inspection with acetic acid or Lugol's iodine at Mulago Hospital, Uganda." International Journal of Gynecology & Obstetrics 119, no. 3 (2012): 262–65. http://dx.doi.org/10.1016/j.ijgo.2012.06.015.

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49

Denning, G., and A. B. Fulton. "A simple trypsin resistance assay for muscle and other cell fusion." Journal of Histochemistry & Cytochemistry 34, no. 7 (1986): 959–62. http://dx.doi.org/10.1177/34.7.3086428.

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Muscle cells fusing in vitro have long provided biologists with a tool to study development and gene expression. However, many such studies used morphological assays of cell fusion. We present here a method for assaying fusion at a specific, operationally defined step. Muscle cells grown in monolayer are exposed to trypsin-EDTA solution at 37 degrees C; the trypsin is inactivated, the cells fixed in Lugol's iodine, and 200 to 300 nuclei are counted as being single or multiple. The presence of EDTA is important under standard conditions for muscle culture; however, little difference is seen in

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50

Rabelo, Patrícia Novais, Paula Novais Rabelo, Allyne Fernanda de Paula, et al. "Propylthiouracil-induced agranulocytosis as a rare complication of antithyroid drugs in a patient with Graves’ disease." Revista da Associação Médica Brasileira 65, no. 6 (2019): 755–60. http://dx.doi.org/10.1590/1806-9282.65.6.755.

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SUMMARY INTRODUCTION: Graves’ disease (GD) is an autoimmune disorder characterized by hyperthyroidism. Antithyroid drugs (ATDs) are available as therapy. Agranulocytosis is a rare but potentially fatal complication of this therapy. In this study, we report agranulocytosis induced by propylthiouracil (PTU) in a patient with GD and the difficulties of clinical management. CASE: RNBA, male, 30 years old, with GD, treated with propylthiouracil (PTU). He progressed with pharyngotonsillitis. Then, PTU was suspended and antibiotic, filgrastim, propranolol, and prednisone were initiated. Due to the de

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