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Journal articles on the topic 'LUHMES'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Lauter, Gilbert, Andrea Coschiera, Masahito Yoshihara, et al. "Differentiation of ciliated human midbrain-derived LUHMES neurons." Journal of Cell Science 133, no. 21 (2020): jcs249789. http://dx.doi.org/10.1242/jcs.249789.

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ABSTRACTMany human cell types are ciliated, including neural progenitors and differentiated neurons. Ciliopathies are characterized by defective cilia and comprise various disease states, including brain phenotypes, where the underlying biological pathways are largely unknown. Our understanding of neuronal cilia is rudimentary, and an easy-to-maintain, ciliated human neuronal cell model is absent. The Lund human mesencephalic (LUHMES) cell line is a ciliated neuronal cell line derived from human fetal mesencephalon. LUHMES cells can easily be maintained and differentiated into mature, function

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2

Loser, Dominik, Maria G. Hinojosa, Jonathan Blum, et al. "Functional alterations by a subgroup of neonicotinoid pesticides in human dopaminergic neurons." Archives of Toxicology 95, no. 6 (2021): 2081–107. http://dx.doi.org/10.1007/s00204-021-03031-1.

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AbstractNeonicotinoid pesticides, originally developed to target the insect nervous system, have been reported to interact with human receptors and to activate rodent neurons. Therefore, we evaluated in how far these compounds may trigger signaling in human neurons, and thus, affect the human adult or developing nervous system. We used SH-SY5Y neuroblastoma cells as established model of nicotinic acetylcholine receptor (nAChR) signaling. In parallel, we profiled dopaminergic neurons, generated from LUHMES neuronal precursor cells, as novel system to study nAChR activation in human post-mitotic

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Keighron, Cameron Noah, Sahar Avazzedeh, and Leo R. Quinlan. "Robust In Vitro Models for Studying Parkinson’s Disease? LUHMES Cells and SH-SH5Y Cells." International Journal of Molecular Sciences 25, no. 23 (2024): 13122. https://doi.org/10.3390/ijms252313122.

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As our population ages, there is an increased unmet clinical need surrounding neurodegenerative diseases such as Parkinson’s disease (PD). To tackle this ever-increasing problem, we must ensure that the cell models that we use to develop therapeutics in vitro are robust, reliable, and replicable. In this study, we compared SH-SY5Y cells with LUHMES cells in response to 6-Hydroxydopamine (6OHDA) and 1-Methyl-4-phenylpyridinium (MPP+), two common Parkinson’s insults used in in vitro analysis. Both these cell types have apparent dopaminergic phenotypes, which could aid us in understanding their p

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Ma, Jianjun, Xiaohuan Li, Yongyan Fan, et al. "miR-494-3p Promotes Erastin-Induced Ferroptosis by Targeting REST to Activate the Interplay between SP1 and ACSL4 in Parkinson’s Disease." Oxidative Medicine and Cellular Longevity 2022 (July 29, 2022): 1–17. http://dx.doi.org/10.1155/2022/7671324.

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Background. Ferroptosis is a type of iron-dependent programmed cell death. Ferroptosis has been shown to be a significant factor for the pathogenesis of Parkinson’s disease (PD). However, the mechanism involved in ferroptosis has not been fully elucidated in PD. Methods. Repressor element-1 silencing transcription factor (REST) and specificity protein 1 (SP1) expressions were monitored by qRT-PCR. Cell viability, reactive oxygen species (ROS), and mitochondrial injury were validated by CCK-8, flow cytometry, and transmission electron microscope. The levels of neurons-related proteins and ferro

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Schildknecht, Stefan. "Etablierung von LUHMES als Zellmodell menschlicher Dopamin-Neurone." BIOspektrum 20, no. 5 (2014): 583. http://dx.doi.org/10.1007/s12268-014-0485-3.

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Norouzi Esfahani, Emad, Tomas Knedlik, Sang Hun Shin, et al. "Remodeling of Mitochondria–Endoplasmic Reticulum Contact Sites Accompanies LUHMES Differentiation." Biomolecules 15, no. 1 (2025): 126. https://doi.org/10.3390/biom15010126.

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Neural progenitor cells (NPCs) are often used to study the subcellular mechanisms underlying differentiation into neurons in vitro. Works published to date have focused on the pathways that distinguish undifferentiated NPCs from mature neurons, neglecting the earlier and intermediate stages of this process. Current evidence suggests that mitochondria interaction with the ER is fundamental to a wide range of intracellular processes. However, it is not clear whether and how the mitochondria–ER interactions differ between NPCs and their differentiated counterparts. Here we take advantage of the w

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Nishi, Kento, Hiroto Izumi, Taisuke Tomonaga, Chikage Nagano, Yasuo Morimoto, and Seichi Horie. "IL-6-Mediated Upregulated miRNAs in Extracellular Vesicles Derived from Lund Human Mesencephalic (LUHMES) Cells: Effects on Astrocytes and Microglia." Biomolecules 13, no. 5 (2023): 718. http://dx.doi.org/10.3390/biom13050718.

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Psychological stress plays a major role in depression, and interleukin-6 (IL-6) is elevated during depression and psychological stress. MicroRNAs (miRNAs) in extracellular vesicles (EVs), including exosomes and microvesicles, suppress mRNA expression in other cells when endocytosed. In this study, we analyzed the effect of IL-6 on EVs secreted by neural precursor cells. Cells from the human immortalized neural precursor cell line LUHMES were treated with IL-6. EVs were collected using a nanofiltration method. We then analyzed the uptake of LUHMES-derived EVs by astrocytes (ACs) and microglia (

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Brüll, Markus, Nils Geese, Ivana Celardo, Michael Laumann, and Marcel Leist. "Preparation of Viable Human Neurites for Neurobiological and Neurodegeneration Studies." Cells 13, no. 3 (2024): 242. http://dx.doi.org/10.3390/cells13030242.

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Few models allow the study of neurite damage in the human central nervous system. We used here dopaminergic LUHMES neurons to establish a culture system that allows for (i) the observation of highly enriched neurites, (ii) the preparation of the neurite fraction for biochemical studies, and (iii) the measurement of neurite markers and metabolites after axotomy. LUHMES-based spheroids, plated in culture dishes, extended neurites of several thousand µm length, while all somata remained aggregated. These cultures allowed an easy microscopic observation of live or fixed neurites. Neurite-only cult

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Kraushaar, Udo, Dominik Loser, Timm Danker, Clemens Moeller, and Marcel Leist. "Electrophysiological evaluation of LUHMES cells as model of human dopaminergic neurons." Journal of Pharmacological and Toxicological Methods 105 (September 2020): 106823. http://dx.doi.org/10.1016/j.vascn.2020.106823.

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10

Zhang, Xiao-min, Ming Yin, and Min-hua Zhang. "Cell-based assays for Parkinson's disease using differentiated human LUHMES cells." Acta Pharmacologica Sinica 35, no. 7 (2014): 945–56. http://dx.doi.org/10.1038/aps.2014.36.

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11

Tüshaus, Johanna, Evans Sioma Kataka, Jan Zaucha, Dmitrij Frishman, Stephan A. Müller, and Stefan F. Lichtenthaler. "Neuronal Differentiation of LUHMES Cells Induces Substantial Changes of the Proteome." PROTEOMICS 21, no. 1 (2020): 2000174. http://dx.doi.org/10.1002/pmic.202000174.

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12

Tong, Zhi-Bin, John Braisted, Pei-Hsuan Chu, and David Gerhold. "The MT1G Gene in LUHMES Neurons Is a Sensitive Biomarker of Neurotoxicity." Neurotoxicity Research 38, no. 4 (2020): 967–78. http://dx.doi.org/10.1007/s12640-020-00272-3.

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13

Shah, Ruth R., Justyna Cholewa-Waclaw, Faith C. J. Davies, et al. "Efficient and versatile CRISPR engineering of human neurons in culture to model neurological disorders." Wellcome Open Research 1 (November 15, 2016): 13. http://dx.doi.org/10.12688/wellcomeopenres.10011.1.

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The recent identification of multiple new genetic causes of neurological disorders highlights the need for model systems that give experimental access to the underlying biology. In particular, the ability to couple disease-causing mutations with human neuronal differentiation systems would be beneficial. Gene targeting is a well-known approach for dissecting gene function, but low rates of homologous recombination in somatic cells (including neuronal cells) have traditionally impeded the development of robust cellular models of neurological disorders. Recently, however, CRISPR/Cas9 gene editin

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Nicolai, Merle M., Barbara Witt, Sharleen Friese, et al. "Mechanistic studies on the adverse effects of manganese overexposure in differentiated LUHMES cells." Food and Chemical Toxicology 161 (March 2022): 112822. http://dx.doi.org/10.1016/j.fct.2022.112822.

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Ali, Nilufar, Mukta S. Sane, Huiyuan Tang, et al. "6-hydroxydopamine affects multiple pathways to induce cytotoxicity in differentiated LUHMES dopaminergic neurons." Neurochemistry International 170 (November 2023): 105608. http://dx.doi.org/10.1016/j.neuint.2023.105608.

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Theerens, E., O. Simonin, H. Bouchaoui, et al. "P07-25 Air pollution-derived ultrafine particles induce ferroptosis in differentiated human dopaminergic neuronal LUHMES cells." Toxicology Letters 368 (September 2022): S129—S130. http://dx.doi.org/10.1016/j.toxlet.2022.07.368.

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17

Scholz, Diana, Dominik Pöltl, Andreas Genewsky, et al. "Rapid, complete and large-scale generation of post-mitotic neurons from the human LUHMES cell line." Journal of Neurochemistry 119, no. 5 (2011): 957–71. http://dx.doi.org/10.1111/j.1471-4159.2011.07255.x.

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Beliakov, Sergei V., Victor Blokhin, Sergey A. Surkov, and Michael V. Ugrumov. "LUHMES Cells: Phenotype Refinement and Development of an MPP+-Based Test System for Screening Antiparkinsonian Drugs." International Journal of Molecular Sciences 24, no. 1 (2023): 733. http://dx.doi.org/10.3390/ijms24010733.

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The low effectiveness of symptomatic pharmacotherapy for Parkinson’s disease (PD), which compensates for dopamine (DA) deficiency under degeneration of nigrostriatal dopaminergic (DAergic) neurons, could apparently be improved with neuroprotective therapy, which slows down neurodegeneration and PD progression. For this, it is necessary to have a DAergic cell line for the development of a PD model to screen neuroprotectors. We used immortalized human embryonic mesencephalon LUHMES cells (LCs) differentiated into DAergic neurons. The aim of this study was to characterize the phenotype of differe

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19

Grillberger, Karin, Eike Cöllen, Claudia Immacolata Trivisani, Jonathan Blum, Marcel Leist, and Gerhard F. Ecker. "Structural Insights into Neonicotinoids and N-Unsubstituted Metabolites on Human nAChRs by Molecular Docking, Dynamics Simulations, and Calcium Imaging." International Journal of Molecular Sciences 24, no. 17 (2023): 13170. http://dx.doi.org/10.3390/ijms241713170.

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Neonicotinoid pesticides were initially designed in order to achieve species selectivity on insect nicotinic acetylcholine receptors (nAChRs). However, concerns arose when agonistic effects were also detected in human cells expressing nAChRs. In the context of next-generation risk assessments (NGRAs), new approach methods (NAMs) should replace animal testing where appropriate. Herein, we present a combination of in silico and in vitro methodologies that are used to investigate the potentially toxic effects of neonicotinoids and nicotinoid metabolites on human neurons. First, an ensemble dockin

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Smirnova, L., G. Harris, J. Delp, et al. "A LUHMES 3D dopaminergic neuronal model for neurotoxicity testing allowing long-term exposure and cellular resilience analysis." Archives of Toxicology 90, no. 11 (2015): 2725–43. http://dx.doi.org/10.1007/s00204-015-1637-z.

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21

Brzóska, Kamil, Malwina Czerwińska, and Marcin Kruszewski. "Differential lncRNA Expression in Undifferentiated and Differentiated LUHMES Cells Following Co-Exposure to Silver Nanoparticles and Nanoplastic." Materials 18, no. 12 (2025): 2690. https://doi.org/10.3390/ma18122690.

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Human exposure to micro- and nanoplastic (MNP) has become an increasing concern due to its accumulation in the environment and human body. In the human organism, MNP accumulates in various tissues, including the central nervous system, where it is associated which neurotoxic effects. Beyond its inherent toxicity, MNP also acts as a carrier for various chemical contaminants, including metals. Consequently, recent studies emphasize the importance of the evaluation of co-exposure scenarios involving MNP and other types of nanoparticles. In this study, we investigated effects of co-exposure to 20

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Rosado-Ramos, Rita, Joana Godinho-Pereira, Daniela Marques, et al. "Small Molecule Fisetin Modulates Alpha–Synuclein Aggregation." Molecules 26, no. 11 (2021): 3353. http://dx.doi.org/10.3390/molecules26113353.

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Phenolic compounds are thought to be important to prevent neurodegenerative diseases (ND). Parkinson’s Disease (PD) is a neurodegenerative disorder known for its typical motor features, the deposition of α-synuclein (αsyn)-positive inclusions in the brain, and for concomitant cellular pathologies that include oxidative stress and neuroinflammation. Neuroprotective activity of fisetin, a dietary flavonoid, was evaluated against main hallmarks of PD in relevant cellular models. At physiologically relevant concentrations, fisetin protected SH-SY5Y cells against oxidative stress overtaken by tert-

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Smirnova, L., G. Harris, H. Hogberg, S. Martos, and T. Hartung. "miRNomics, metabolomics and 3D neuronal differentiation of LUHMES progenitor cells as an in vitro model for DNT studies." Toxicology Letters 221 (August 2013): S154. http://dx.doi.org/10.1016/j.toxlet.2013.05.321.

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Łuczkowska, Karolina, Olga Taryma-Leśniak, Jan Bińkowski, et al. "Long-Term Treatment with Bortezomib Induces Specific Methylation Changes in Differentiated Neuronal Cells." Cancers 14, no. 14 (2022): 3402. http://dx.doi.org/10.3390/cancers14143402.

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Bortezomib (BTZ) is proteasome inhibitor, effectively used in the treatment of multiple myeloma, but frequently discontinued due to peripheral neuropathy, which develops in patients after consecutive treatment cycles. The molecular mechanisms affected by BTZ in neuronal cells, which result in neuropathy, remain unknown. However, BTZ is unlikely to lead to permanent morphological nerve damage, because neuropathy reverses after discontinuation of treatment, and nerve cells have very limited renewal capacity. We have previously shown that BTZ induces methylation changes in SH-SY5Y cells, which ta

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Blokhin, Victor, Alina V. Lavrova, Sergey A. Surkov, et al. "A New Method for the Visualization of Living Dopaminergic Neurons and Prospects for Using It to Develop Targeted Drug Delivery to These Cells." International Journal of Molecular Sciences 23, no. 7 (2022): 3678. http://dx.doi.org/10.3390/ijms23073678.

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This is the first study aiming to develop a method for the long-term visualization of living nigrostriatal dopaminergic neurons using 1-(2-(bis(4-fluorophenyl)methoxy)ethyl)-4-(3-phenylpropyl)piperazine-BODIPY (GBR-BP), the original fluorescent substance, which is a derivative of GBR-12909, a dopamine uptake inhibitor. This method is based on the authors’ hypothesis about the possibility of specifically internalizing into dopaminergic neurons substances with a high affinity for the dopamine transporter (DAT). Using a culture of mouse embryonic mesencephalic and LUHMES cells (human embryonic me

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Harischandra, Dilshan S., Dharmin Rokad, Matthew L. Neal та ін. "Manganese promotes the aggregation and prion-like cell-to-cell exosomal transmission of α-synuclein". Science Signaling 12, № 572 (2019): eaau4543. http://dx.doi.org/10.1126/scisignal.aau4543.

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The aggregation of α-synuclein (αSyn) is considered a key pathophysiological feature of certain neurodegenerative disorders, collectively termed synucleinopathies. Given that a prion-like, cell-to-cell transfer of misfolded αSyn has been recognized in the spreading of αSyn pathology in synucleinopathies, we investigated the biological mechanisms underlying the propagation of the disease with respect to environmental neurotoxic stress. Considering the potential role of the divalent metal manganese (Mn2+) in protein aggregation, we characterized its effect on αSyn misfolding and transmission in

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el Bouhaddani, Said, Matthias Höllerhage, Hae-Won Uh, et al. "Statistical integration of multi-omics and drug screening data from cell lines." PLOS Computational Biology 20, no. 1 (2024): e1011809. http://dx.doi.org/10.1371/journal.pcbi.1011809.

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Data integration methods are used to obtain a unified summary of multiple datasets. For multi-modal data, we propose a computational workflow to jointly analyze datasets from cell lines. The workflow comprises a novel probabilistic data integration method, named POPLS-DA, for multi-omics data. The workflow is motivated by a study on synucleinopathies where transcriptomics, proteomics, and drug screening data are measured in affected LUHMES cell lines and controls. The aim is to highlight potentially druggable pathways and genes involved in synucleinopathies. First, POPLS-DA is used to prioriti

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Shah, F. J., C. Caviglia, K. Zór, et al. "Impedance-based real-time monitoring of neural stem cell differentiation." Journal of Electrical Bioimpedance 12, no. 1 (2021): 34–49. http://dx.doi.org/10.2478/joeb-2021-0006.

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Abstract We present here the first impedance-based characterization of the differentiation process of two human mesencephalic fetal neural stem lines. The two dopaminergic neural stem cell lines used in this study, Lund human mesencephalic (LUHMES) and human ventral mesencephalic (hVM1 Bcl-XL), have been developed for the study of Parkinsonian pathogenesis and its treatment using cell replacement therapy. We show that if only relying on impedance magnitude analysis, which is by far the most usual approach in, e.g., cytotoxicity evaluation and drug screening applications, one may not be able to

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Gaceb, Abderahim, Marco Barbariga, and Gesine Paul. "An In Vitro Partial Lesion Model of Differentiated Human Mesencephalic Neurons: Effect of Pericyte Secretome on Phenotypic Markers." Journal of Molecular Neuroscience 70, no. 11 (2020): 1914–25. http://dx.doi.org/10.1007/s12031-020-01589-6.

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Abstract Parkinson’s disease (PD) is characterised by the progressive degeneration of dopaminergic (DA) neurons in the substantia nigra pars compacta. Post-mortem data suggests that the loss of DA markers may long precede the cell death, leaving a window to rescue the DA phenotype. Screening for potential neuroprotective or restorative therapies, however, requires that partial lesions of DA neurons can be modelled in vitro. In order to establish a partial lesion model of DA neurons in vitro, we evaluated the effects of different exposure times to 1-methyl-4-phenylpyridinium (MPP+) and 6-hydrox

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Zuberek, M., T. M. Stępkowski, M. Kruszewski, and A. Grzelak. "Exposure of human neurons to silver nanoparticles induces similar pattern of ABC transporters gene expression as differentiation: Study on proliferating and post-mitotic LUHMES cells." Mechanisms of Ageing and Development 171 (April 2018): 7–14. http://dx.doi.org/10.1016/j.mad.2018.02.004.

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Suciu, Ilinca, Johannes Delp, Simon Gutbier, et al. "Dynamic Metabolic and Transcriptional Responses of Proteasome-Inhibited Neurons." Antioxidants 12, no. 1 (2023): 164. http://dx.doi.org/10.3390/antiox12010164.

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Proteasome inhibition is associated with parkinsonian pathology in vivo and degeneration of dopaminergic neurons in vitro. We explored here the metabolome (386 metabolites) and transcriptome (3257 transcripts) regulations of human LUHMES neurons, following exposure to MG-132 [100 nM]. This proteasome inhibitor killed cells within 24 h but did not reduce viability for 12 h. Overall, 206 metabolites were changed in live neurons. The early (3 h) metabolome changes suggested a compromised energy metabolism. For instance, AMP, NADH and lactate were up-regulated, while glycolytic and citric acid cyc

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Akhtar, Lisa N., Sue Choi, Cooper Hayes, et al. "173. HSV-2 Isolates from Neonates with Different Clinical Outcomes Exhibit Different in Vitro and in Vivo phenotypes." Open Forum Infectious Diseases 7, Supplement_1 (2020): S215—S216. http://dx.doi.org/10.1093/ofid/ofaa439.483.

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Abstract Background Herpes simplex virus (HSV) infection of the neonatal brain causes severe meningoencephalitis and permanent neurologic deficits. However, infants infected with HSV at the time of birth follow different clinical courses. Some infants develop only external infection of the skin, eyes, or mouth (SEM disease), while others develop invasive infection of the central nervous system resulting in encephalitis (CNS disease). The factors that explain this clinical divergence are not well understood. While adults can be predisposed to HSV CNS infection by an innate immune defect, no suc

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Delp, Johannes, Andrea Cediel-Ulloa, Ilinca Suciu, et al. "Neurotoxicity and underlying cellular changes of 21 mitochondrial respiratory chain inhibitors." Archives of Toxicology 95, no. 2 (2021): 591–615. http://dx.doi.org/10.1007/s00204-020-02970-5.

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AbstractInhibition of complex I of the mitochondrial respiratory chain (cI) by rotenone and methyl-phenylpyridinium (MPP +) leads to the degeneration of dopaminergic neurons in man and rodents. To formally describe this mechanism of toxicity, an adverse outcome pathway (AOP:3) has been developed that implies that any inhibitor of cI, or possibly of other parts of the respiratory chain, would have the potential to trigger parkinsonian motor deficits. We used here 21 pesticides, all of which are described in the literature as mitochondrial inhibitors, to study the general applicability of AOP:3

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Göx, Robert F. "Alfred Luhmer 65 Jahre." Schmalenbachs Zeitschrift für betriebswirtschaftliche Forschung 58, no. 4 (2006): 525–27. http://dx.doi.org/10.1007/bf03371664.

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Mexicana, Fundación. "luhpe info." Promotion & Education 8, no. 1 (2001): 32–33. http://dx.doi.org/10.1177/102538230100800111.

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Mukherjee, Sagnick, Jonathan J. Fortney, Rebecca Jensen-Clem, Xianyu Tan, Mark S. Marley, and Natasha E. Batalha. "Modeling Polarization Signals from Cloudy Brown Dwarfs Luhman 16 A and B in Three Dimensions." Astrophysical Journal 923, no. 1 (2021): 113. http://dx.doi.org/10.3847/1538-4357/ac2d92.

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Abstract The detection of disk-integrated polarization from Luhman 16 A and B in the H band, and subsequent modeling, has been interpreted in the framework of zonal cloud bands on these bodies. Recently, Tan and Showman investigated the 3D atmospheric circulation and cloud structures of brown dwarfs with general circulation models (GCMs), and their simulations yielded complex cloud distributions showing some aspects of zonal jets, but also complex vortices that cannot be captured by a simple model. Here we use these 3D GCMs specific to Luhman 16 A and B, along with the 3D Monte Carlo radiative

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ALhakeem, Naseem Sh, Medhat E. Nasser, and Ghazi H. AL-Sharaa. "3D Geological Modeling for Yamama Reservoir in Subba, Luhias and Ratawi Oil Fields, South of Iraq." Iraqi Journal of Science 60, no. 5 (2019): 1023–36. http://dx.doi.org/10.24996/ijs.2019.60.5.12.

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3D geological model for each reservoir unit comprising the Yamama Formation revealed to that the formation is composed of alternating reservoirs and barriers. In Subba and Luhais fields the formation began with barrier YB-1 and four more barriers (YB-2, YB-3, YB-4, YB-5), separated five reservoirs (YR-A, YR-B, YR-C, YR-D, YR-E) ranging in thickness from 70 to 80 m for each of them deposited by five sedimentary cycles. In the Ratawi field the formation was divided into three reservoir units (YR-A, YR-B, and YR-C) separated by two barrier units (YB-2 and YB-3), the first cycle is missing in Rata

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Muhammad, Qasim Jamshed ul Qadir Abdul Samad Muhammad Akber Kazi. "MEDICO-LEGAL CASES: NATURE, FREQUENCY AND PERCENTAGE AT LUHMS HYDERABAD, PAKISTAN." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 12 (2018): 16730–33. https://doi.org/10.5281/zenodo.2505000.

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<em>Medico-legal cases are among the daily practice all around the globe to claim one’s rights and to punish the culprit. The nature of medicolegal cases various from area to area and social and cultural values of every region. The current research work conducted in the medicolegal section of the Liaquat University Hospital from January 2015 to 31 December 2015. Patients of all age groups of both genders were included registered as medico-legal while non-medicolegal cases were excluded. Data generated was analyzed on SPSS Version 22.Total 3636 patients were seen in one year duration top

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Handhal, Amna M. "Evaluating the reservoir properties of Nahr Umr Formation at Luhais oil field, southern Iraq using well logs data." BASRA JOURNAL OF SCIENCE 38, no. 2 (2020): 294–327. http://dx.doi.org/10.29072/basjs.202028.

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Nahr Umr formation in the oilfield of Luhais in southern Iraq is one of productive clastic reservoirs which formed during the secondary Alpine cycle. To cover the objectives of this study, twenty two wells were selected to evaluate the reservoir characteristics of the Nahr Umr formation in Luhais oilfield in southern Iraq. The petrophysical characteristics (Shale Volume (Vsh), Bulk volume hydrocarbon (BVH), Hydrocarbon saturation (Sh), Water saturation (Sw), thickness, Bulk water volume (BVW), porosity (φ ) were calculated and interpreted using the Geolog software. The Nahr Umr Formation was d

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Fuda, Nguyen, Dániel Apai, Domenico Nardiello, Xianyu Tan, Theodora Karalidi, and Luigi Rolly Bedin. "Latitude-dependent Atmospheric Waves and Long-period Modulations in Luhman 16 B from the Longest Light Curve of an Extrasolar World." Astrophysical Journal 965, no. 2 (2024): 182. http://dx.doi.org/10.3847/1538-4357/ad2c84.

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Abstract In this work, we present the longest photometric monitoring of up to 1200 hr of the strongly variable brown dwarf binaries Luhman 16 AB and provide evidence of ±5% variability on a timescale of several to hundreds of hours for this object. We show that short-period rotational modulation around 5 hr (k = 1 wavenumber) and 2.5 hr (k = 2 wavenumber) dominate the variability under 10 hr, where the planetary-scale wave model composed of k = 1 and k = 2 waves provides good fits to both the periodograms and light curve. In particular, models consisting of three to four sine waves could expla

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García Sánchez, Ángel. "Apuntes para un crítica ilustrada a Niklas Luhman." ENDOXA 1, no. 11 (1999): 271. http://dx.doi.org/10.5944/endoxa.11.1999.4935.

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Bachur, João Paulo. "O Estado de bem-estar em Hayek e Luhman." Tempo Social 25, no. 2 (2013): 101–21. http://dx.doi.org/10.1590/s0103-20702013000200006.

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Alher, Ahmed Abdulmueen, Mohammed Saleh Aljawad, and Abdullah Abdulhasan Ali. "Static Model of Zubair Reservoir in Luhais Oil Field." Iraqi Journal of Chemical and Petroleum Engineering 19, no. 1 (2018): 57–60. http://dx.doi.org/10.31699/ijcpe.2018.1.7.

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Static reservoir modeling is the interacting and analysis of the geological data to visualize the reservoir framework by three-dimensional model and distribute the static reservoir properties. The Petrel E&P software used to incorporate the data. The interpreted log data and core report used in distribution of petrophysical properties of porosity, water saturation and permeability for Zubair reservoir in Luhais oil field. The reservoir discretized to 274968 cells in increments of 300, 200 and 1 meter in the direction of X, Y, and Z respectively. The geostatistical approach used in th

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Arias Díaz, Karina, and Natalia Hernández Mary. "Individuación del individuo: Una posibilidad de resignificar las relaciones de intimidad." Revista Perspectivas: Notas sobre intervención y acción social, no. 20 (November 19, 2018): 65. http://dx.doi.org/10.29344/07171714.20.1249.

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El presente artículo tiene como objetivo develar la resignificación de los espacios de intimidad de las relaciones interpersonales en el contexto de las sociedades modernas, en las cuales se ha desarrollado un proceso clave: la individuación del individuo. Desde las propuestas que ofrece Luhman surge la posibilidad de afirmar que los espacios de intimidad existen y son validados por los individuos modernos.

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Gagné, Jonathan, Leslie Moranta, Jacqueline K. Faherty, et al. "The Oceanus Moving Group: A New 500 Myr Old Host for the Nearest Brown Dwarf." Astrophysical Journal 945, no. 2 (2023): 119. http://dx.doi.org/10.3847/1538-4357/acb8b7.

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Abstract We report the discovery of the Oceanus moving group, a ≈500 Myr old group with 50 members and candidate members at distances 2–50 pc from the Sun, using an unsupervised clustering analysis of nearby stars with Gaia DR3 data. This new moving group includes the nearest brown dwarf WISE J104915.57–531906.1 AB (Luhman 16 AB) at a distance of 2 pc, which was previously suspected to be young (600–800 Myr) based on a comparison of its dynamical mass measurements with brown dwarf evolutionary models. We use empirical color–magnitude sequences, stellar activity, and gyrochronology to determine

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Prihatini, P. M., I. K. G. D. Putra, I. A. D. Giriantari, and M. Sudarma. "Complete agglomerative hierarchy document’s clustering based on fuzzy luhn’s gibbs latent dirichlet allocation." International Journal of Electrical and Computer Engineering (IJECE) 9, no. 3 (2019): 2103. http://dx.doi.org/10.11591/ijece.v9i3.pp2103-2111.

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Agglomerative hierarchical is a bottom up clustering method, where the distances between documents can be retrieved by extracting feature values using a topic-based latent dirichlet allocation method. To reduce the number of features, term selection can be done using Luhn’s Idea. Those methods can be used to build the better clusters for document. But, there is less research discusses it. Therefore, in this research, the term weighting calculation uses Luhn’s Idea to select the terms by defining upper and lower cut-off, and then extracts the feature of terms using gibbs sampling latent dirichl

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López- Jiménez, Daniel Fernando, and Patricio Vergara. "Power, authority and government of companies in the information society." ComHumanitas: revista científica de comunicación 10, no. 1 (2019): 69–81. http://dx.doi.org/10.31207/rch.v10i1.189.

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In the present article, an analysis is made about the power relations, authority and government of the five biggest TI and communications companies of the world in 2017: Apple, Microsoft, Google, Facebook, Amazon; from the philosopher-political approach of Plato, Aristotle, Weber, Foucault, Arendt, Luhman and Herrero, in order to establish possible similarities between the politic power and the economical-business power, from the critical postures of Byung-Chul Han, McLuhan, Castells and Negroponte.

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Manhi, Maha, and Hamid Alsultan. "Stratigraphic Analysis of the Nahr Umr Formation in the Luhais Oil Field, South Iraq." Iraqi Geological Journal 56, no. 2D (2023): 94–102. http://dx.doi.org/10.46717/igj.56.2d.7ms-2023-10-13.

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The Nahr Umr Formation, which is Albian-Early Turonian in age, was investigated in the Nahr Umr Formation succession at two wells of the Luhais oil field in southern Iraq. The study defined sedimentary facies, types, and distribution of porosity and their relationship to sedimentary facies, as well as different types of diagenetic processes. It also included the distribution of facies in the Nahr Umr Formation in relation to suggested depositional settings. Thin sections of the cores from the two chosen boreholes (Lu 39 and Lu 43) in the Luhais Oil Field were used to study the petrography and

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Karalidi, Theodora, Dániel Apai, Mark S. Marley, and Esther Buenzli. "MAPS OF EVOLVING CLOUD STRUCTURES IN LUHMAN 16AB FROMHSTTIME-RESOLVED SPECTROSCOPY." Astrophysical Journal 825, no. 2 (2016): 90. http://dx.doi.org/10.3847/0004-637x/825/2/90.

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Moffett, Madeline, and Mayur S. Parmar. "LUHMES Cells: In Vitro Model for Studying Tauopathy in Alzheimer’s Disease." Alzheimer's & Dementia 20, S1 (2024). https://doi.org/10.1002/alz.091874.

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AbstractBackgroundAlzheimer’s disease (AD) is a common neurodegenerative disorder that results in the accumulation of amyloid‐beta, neurofibrillary tangles, and progressive cognitive decline. Despite extensive research into the pathophysiology of AD and potential treatments, a definitive cure remains elusive. Appropriate in vitro cell models are crucial for understanding pathophysiology and drug screening for AD. Cell lines like HEK293, HeLa, SH‐SY5Y, and PC have been used to study AD pathology. However, these models lack neuronal cell characteristics and do not express endogenous tau, a micro

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