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1

Belgrave, Danielle C. M., Iain Buchan, Christopher Bishop, Lesley Lowe, Angela Simpson, and Adnan Custovic. "Trajectories of Lung Function during Childhood." American Journal of Respiratory and Critical Care Medicine 189, no. 9 (2014): 1101–9. http://dx.doi.org/10.1164/rccm.201309-1700oc.

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2

Agusti, Alvar, and Rosa Faner. "Lung function trajectories in health and disease." Lancet Respiratory Medicine 7, no. 4 (2019): 358–64. http://dx.doi.org/10.1016/s2213-2600(18)30529-0.

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3

Ghezzi, Michele, and Ahmad Kantar. "Lung Function in Childhood: Designing the Future Trajectories." Children 10, no. 6 (2023): 1036. http://dx.doi.org/10.3390/children10061036.

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4

Krishnan, Jamuna K., and Fernando J. Martinez. "Lung function trajectories and chronic obstructive pulmonary disease." Current Opinion in Pulmonary Medicine 24, no. 2 (2018): 124–29. http://dx.doi.org/10.1097/mcp.0000000000000456.

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5

Burki, Talha Khan. "Lung function trajectories differ in patients with COPD." Lancet Respiratory Medicine 3, no. 9 (2015): 675. http://dx.doi.org/10.1016/s2213-2600(15)00329-x.

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6

Ferraro, Valentina Agnese, Raimondo Junior Castaldo, Valentina Tonazzo, Stefania Zanconato, and Silvia Carraro. "Lung Function in Children with Primary Ciliary Dyskinesia." Children 10, no. 2 (2023): 290. http://dx.doi.org/10.3390/children10020290.

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Background: Primary ciliary dyskinesia (PCD) is characterized by impaired mucociliary clearance that results in accumulation of mucus and bacteria in the airways. Lower respiratory tract infections lead to airway remodeling and lung function impairment. The aim of our narrative review is to discuss available data on lung function in PCD children, focusing on risk factors for lung function impairment. Methods: Relevant published studies searching MEDLINE/Pubmed are included in this narrative review, using these terms: “primary ciliary dyskinesia” and “pulmonary function test” or “spirometry” or
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7

Abraham, Shinu. "Lung-function trajectories leading to chronic obstructive pulmonary disease." South African Respiratory Journal 21, no. 3 (2015): 83. http://dx.doi.org/10.7196/10.2015.v21i3.83.

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8

Lange, Peter, Bartolome Celli, Alvar Agustí, et al. "Lung-Function Trajectories Leading to Chronic Obstructive Pulmonary Disease." New England Journal of Medicine 373, no. 2 (2015): 111–22. http://dx.doi.org/10.1056/nejmoa1411532.

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9

Puhan, Milo A. "Predicting individual lung-function trajectories: An opportunity for prevention?" Canadian Medical Association Journal 188, no. 14 (2016): 997–98. http://dx.doi.org/10.1503/cmaj.160611.

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10

Maurer, J. R. "Lung-Function Trajectories Leading to Chronic Obstructive Pulmonary Disease." Yearbook of Medicine 2016 (2016): 218–20. https://doi.org/10.1016/s0084-3873(16)30202-4.

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11

Maurer, J. R. "Lung-Function Trajectories Leading to Chronic Obstructive Pulmonary Disease." Yearbook of Pulmonary Disease 2016 (2016): 66–67. https://doi.org/10.1016/j.ypdi.2016.02.022.

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12

Peralta, Gabriela P., Alicia Abellan, Parisa Montazeri, et al. "Early childhood growth is associated with lung function at 7 years: a prospective population-based study." European Respiratory Journal 56, no. 6 (2020): 2000157. http://dx.doi.org/10.1183/13993003.00157-2020.

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Previous studies have related early postnatal growth with later lung function but their interpretation is limited by the methods used to assess a child's growth. We aimed to assess the association of early childhood growth, measured by body mass index (BMI) trajectories up to 4 years, with lung function at 7 years.We included 1257 children from the Spanish Infancia y Medio Ambiente population-based birth cohort. Early childhood growth was classified into five categories based on BMI trajectories up to 4 years previously identified using latent class growth analysis. These trajectories differed
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13

Roda, Célina, Osama Mahmoud, Gabriela P. Peralta, et al. "Physical-activity trajectories during childhood and lung function at 15 years: findings from the ALSPAC cohort." International Journal of Epidemiology 49, no. 1 (2019): 131–41. http://dx.doi.org/10.1093/ije/dyz128.

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Abstract Background Although physical activity has many known health benefits, its association with lung function in childhood/adolescence remains unclear. We examined the association of physical-activity trajectories between 11 and 15 years with lung function at 15 years in 2266 adolescents. Methods A population-based cohort of 14 305 singleton births alive at 1 year was recruited in the UK population-based Avon Longitudinal Study of Parents and Children cohort. Physical activity (counts/minute and moderate-to-vigorous physical activity) was assessed for 7 days using an accelerometer at 11, 1
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14

Ali, Gulshan Bano, Dinh Son Bui, Caroline Jane Lodge, et al. "Infant body mass index trajectories and asthma and lung function." Journal of Allergy and Clinical Immunology 148, no. 3 (2021): 763–70. http://dx.doi.org/10.1016/j.jaci.2021.02.020.

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15

Bui, Dinh S., Alvar Agusti, Haydn Walters, et al. "Lung function trajectory and biomarkers in the Tasmanian Longitudinal Health Study." ERJ Open Research 7, no. 3 (2021): 00020–2021. http://dx.doi.org/10.1183/23120541.00020-2021.

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Background and objectiveDifferent lung function trajectories through life can lead to COPD in adulthood. This study investigated whether circulating levels of biomarkers can differentiate those with accelerated (AD) from normal decline (ND) trajectories.MethodsThe Tasmanian Longitudinal Health Study (TAHS) is a general population study that measured spirometry and followed up participants from ages 7 to 53 years. Based on their forced expiratory volume in 1 s (FEV1) trajectories from age 7 to 53 years, this analysis included those with COPD at age 53 years (60 with AD and 94 with ND) and contr
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16

Le Thai, C., P. Bokov, B. Mahut, C. Delclaux, and N. Beydon. "Lung function trajectories in asthmatic children after the onset of omalizumab." Pediatric Respiratory Journal 02, no. 04 (2024): 162. http://dx.doi.org/10.56164/pediatrrespirj.2024.62.

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17

Dy, A. B. C., J. Zhai, B. Hallmark, et al. "Lung Function Trajectories in Young, Mid-adult Life Predict Premature Mortality." American Journal of Respiratory and Critical Care Medicine 211, Abstracts (2025): A7122. https://doi.org/10.1164/ajrccm.2025.211.abstracts.a7122.

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18

Jordan, Brian K., and Cindy T. McEvoy. "Trajectories of Lung Function in Infants and Children: Setting a Course for Lifelong Lung Health." Pediatrics 146, no. 4 (2020): e20200417. http://dx.doi.org/10.1542/peds.2020-0417.

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19

Mogensen, Ida, Judith M. Vonk, Sara R. A. Wijnant, et al. "Blood eosinophil level and lung function trajectories: cross-sectional and longitudinal studies in European cohorts." ERJ Open Research 6, no. 4 (2020): 00320–2020. http://dx.doi.org/10.1183/23120541.00320-2020.

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BackgroundElevated blood eosinophils have been associated with lower lung function and are believed to be associated with accelerated lung function decline.MethodBlood eosinophils were measured in four cohorts: <45 years cohort within the Vlagtwedde–Vlaardingen (V&V) study, the Uppsala cohort of the European Community Respiratory Health Survey (ECRHS-Uppsala; <45 years), ≥45 years cohort within the V&V study, and the Rotterdam study (≥45 years). Blood eosinophils at baseline were classified as normal (<300 cells·μL−1) or elevated (≥300 cells·μL−1). Lung function was measured a
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20

Grudzinski, K., G. Y. H. Liu, L. Colangelo, et al. "Adult Life Course Trajectories of Lung Function and the Development of Interstitial Lung Abnormalities: The CARDIA Lung Study." American Journal of Respiratory and Critical Care Medicine 211, Abstracts (2025): A1001. https://doi.org/10.1164/ajrccm.2025.211.abstracts.a1001.

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21

Peralta, Gabriela P., Alessandro Marcon, Anne-Elie Carsin, et al. "Body mass index and weight change are associated with adult lung function trajectories: the prospective ECRHS study." Thorax 75, no. 4 (2020): 313–20. http://dx.doi.org/10.1136/thoraxjnl-2019-213880.

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BackgroundPrevious studies have reported an association between weight increase and excess lung function decline in young adults followed for short periods. We aimed to estimate lung function trajectories during adulthood from 20-year weight change profiles using data from the population-based European Community Respiratory Health Survey (ECRHS).MethodsWe included 3673 participants recruited at age 20–44 years with repeated measurements of weight and lung function (forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1)) in three study waves (1991–93, 1999–2003, 2010–14) until they
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22

Mutz, Julian, and Cathryn Lewis. "Depression and Age-Related Changes in Body Composition, Cardiovascular Function, Grip Strength, and Lung Function." Innovation in Aging 5, Supplement_1 (2021): 440. http://dx.doi.org/10.1093/geroni/igab046.1709.

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Abstract Individuals with mental disorders, on average, die prematurely, have higher levels of physical comorbidities and may experience accelerated ageing. In individuals with lifetime depression and healthy controls, we examined associations between age and multiple physiological measures. The UK Biobank study recruited >500,000 participants, aged 37-73, between 2006–2010. Generalised additive models were used to examine associations between age and grip strength, cardiovascular function, body composition, lung function and bone mineral density. Analyses were conducted separately in m
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23

Okyere, Daniel O., Dinh S. Bui, George R. Washko, et al. "Predictors of lung function trajectories in population‐based studies: A systematic review." Respirology 26, no. 10 (2021): 938–59. http://dx.doi.org/10.1111/resp.14142.

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24

Patel, Naiya B., and Christopher Parrish. "Prospective Study of Disease Persistence and Lung Function Trajectories of Childhood Asthma." Pediatrics 150, Supplement 3 (2022): S45—S46. http://dx.doi.org/10.1542/peds.2022-059346ppp.

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25

Arshad, Syed H., Claire Hodgekiss, John W. Holloway, et al. "Lung Function Trajectories From Childhood To Young Adulthood; A Peek Into The Future Of Lung Health?" Journal of Allergy and Clinical Immunology 141, no. 2 (2018): AB81. http://dx.doi.org/10.1016/j.jaci.2017.12.260.

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26

Washko, George R., Laura A. Colangelo, Raul San José Estépar, et al. "Adult Life-Course Trajectories of Lung Function and the Development of Emphysema: The CARDIA Lung Study." American Journal of Medicine 133, no. 2 (2020): 222–30. http://dx.doi.org/10.1016/j.amjmed.2019.06.049.

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27

Zhou, Chunxiang, Wei Zeng, Xiaoyan Chen, et al. "Association between lung function and bone mineral density in children and adolescents: Insights from the NHANES." Medicine 103, no. 1 (2024): e36752. http://dx.doi.org/10.1097/md.0000000000036752.

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Bone development and lung function are integral to child and adolescent health. Both influence an individual’s overall well-being and potentially affect long-term health. Utilizing a comprehensive dataset from the National Health and Nutrition Examination Survey, this study aims to elucidate the relationship between lung function and bone mineral density (BMD) in a representative sample of children and adolescents. The analysis covered 3410 participants aged 8 to 19 years. We employed weighted multivariate linear regression and restricted cubic spline curve visualizations to explore the intric
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28

Krol, Katherine A., and Augusto A. Litonjua. "Beyond obesity: The complex relationship between early growth trajectories and later lung function." Journal of Allergy and Clinical Immunology 148, no. 3 (2021): 713–15. http://dx.doi.org/10.1016/j.jaci.2021.07.009.

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29

Allinson, James P., Rebecca Hardy, Gavin C. Donaldson, Seif O. Shaheen, Diana Kuh, and Jadwiga A. Wedzicha. "Combined Impact of Smoking and Early-Life Exposures on Adult Lung Function Trajectories." American Journal of Respiratory and Critical Care Medicine 196, no. 8 (2017): 1021–30. http://dx.doi.org/10.1164/rccm.201703-0506oc.

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30

Peralta, Gabriela P., Elaine Fuertes, Raquel Granell, et al. "Childhood Body Composition Trajectories and Adolescent Lung Function. Findings from the ALSPAC study." American Journal of Respiratory and Critical Care Medicine 200, no. 1 (2019): 75–83. http://dx.doi.org/10.1164/rccm.201806-1168oc.

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31

Lødrup Carlsen, Karin C., Petter Mowinckel, Vegard Hovland, Geir Håland, Amund Riiser, and Kai-Håkon Carlsen. "Lung function trajectories from birth through puberty reflect asthma phenotypes with allergic comorbidity." Journal of Allergy and Clinical Immunology 134, no. 4 (2014): 917–23. http://dx.doi.org/10.1016/j.jaci.2014.05.020.

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32

Gold, Diane R., Joanne E. Sordillo, and Brent A. Coull. "Lung Function Tracking throughout Childhood: Growth Trajectories May Not Be Set in Stone." Journal of Allergy and Clinical Immunology: In Practice 8, no. 4 (2020): 1272–74. http://dx.doi.org/10.1016/j.jaip.2020.01.043.

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33

Wilson, T. A., M. J. Hill, and R. D. Hubmayr. "Regional lung volume trajectories during expiratory flow in dogs." Journal of Applied Physiology 80, no. 4 (1996): 1144–48. http://dx.doi.org/10.1152/jappl.1996.80.4.1144.

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Parenchymal markers were placed in the left caudal lobes of anesthetized dogs, and the three-dimensional positions of the markers were tracked by biplane videofluoroscopy during expiration from total lung capacity (TLC) to approximately 30% TLC at steady expiratory flows of 0.3-7% TLC/s. Regional volumes of samples of parenchyma with volumes at TLC of 1-5 cm3 were obtained by computing the volumes of tetrahedral defined by taking the markers, four at a time, as apices of the tetrahedra, Regional volume (Vr), as a fraction of volume at TLC, was plotted against average volume (VL), as a fraction
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34

Vestbo, Jørgen. "Childhood Asthma, Lung Function Trajectories, and Chronic Obstructive Pulmonary Disease: An Additional Step Forward." Annals of the American Thoracic Society 15, no. 9 (2018): 1030–31. http://dx.doi.org/10.1513/annalsats.201807-440ed.

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35

van Oostrom, Sandra H., Peter M. Engelfriet, W. M. Monique Verschuren, et al. "Aging-related trajectories of lung function in the general population—The Doetinchem Cohort Study." PLOS ONE 13, no. 5 (2018): e0197250. http://dx.doi.org/10.1371/journal.pone.0197250.

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36

Mutz, Julian, and Cathryn M. Lewis. "Lifetime depression and age-related changes in body composition, cardiovascular function, grip strength and lung function: sex-specific analyses in the UK Biobank." BJPsych Open 7, S1 (2021): S44. http://dx.doi.org/10.1192/bjo.2021.166.

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AimsIndividuals with mental disorders, on average, die prematurely, have higher levels of physical comorbidities and may experience accelerated ageing. In individuals with lifetime depression and healthy controls, we examined associations between age and multiple physiological measures.MethodThe UK Biobank study recruited >500,000 participants, aged 37–73 years, between 2006–2010. Generalised additive models were used to examine associations between age and grip strength, cardiovascular function, body composition, lung function and bone mineral density. Analyses were conducted separately in
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37

Deliveira, Thais Lopes, and Sara Hägg. "FUNCTIONAL AGING TRAJECTORIES AND DRUG INTERACTIONS." Innovation in Aging 6, Supplement_1 (2022): 243. http://dx.doi.org/10.1093/geroni/igac059.965.

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Abstract Markers of functional aging can be used to track biological aging longitudinally and how it changes in response to the environment, e.g., drugs. We aimed to investigate how different drug classes may alter functional aging trajectories using data from the National E-infrastructure of Aging Research (NEAR) in Sweden. Data were harmonized across several longitudinal cohorts of aging for general cognitive performance, grip strength, walking speed, sensory ability (visual and hearing), lung function and assessment of frailty using the accumulation deficit model known as the frailty index.
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38

Deolmi, Michela, Nicola Mattia Decarolis, Matteo Motta, et al. "Early Origins of Chronic Obstructive Pulmonary Disease: Prenatal and Early Life Risk Factors." International Journal of Environmental Research and Public Health 20, no. 3 (2023): 2294. http://dx.doi.org/10.3390/ijerph20032294.

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The main risk factor for chronic obstructive pulmonary disease (COPD) is active smoking. However, a considerable amount of people with COPD never smoked, and increasing evidence suggests that adult lung disease can have its origins in prenatal and early life. This article reviews some of the factors that can potentially affect lung development and lung function trajectories throughout the lifespan from genetics and prematurity to respiratory tract infections and childhood asthma. Maternal smoking and air pollution exposure were also analyzed among the environmental factors. The adoption of pre
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39

Zhang, Hui, Xia Li, Lixue Huang, et al. "Lung-function trajectories in COVID-19 survivors after discharge: A two-year longitudinal cohort study." eClinicalMedicine 54 (December 2022): 101668. http://dx.doi.org/10.1016/j.eclinm.2022.101668.

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40

Ross, James C., Peter J. Castaldi, Michael H. Cho, et al. "Longitudinal Modeling of Lung Function Trajectories in Smokers with and without Chronic Obstructive Pulmonary Disease." American Journal of Respiratory and Critical Care Medicine 198, no. 8 (2018): 1033–42. http://dx.doi.org/10.1164/rccm.201707-1405oc.

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41

Marott, Jacob Louis, Truls Sylvan Ingebrigtsen, Yunus Çolak, Jørgen Vestbo, and Peter Lange. "Lung Function Trajectories Leading to Chronic Obstructive Pulmonary Disease as Predictors of Exacerbations and Mortality." American Journal of Respiratory and Critical Care Medicine 202, no. 2 (2020): 210–18. http://dx.doi.org/10.1164/rccm.201911-2115oc.

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42

Simpson, Shannon J., Lidija Turkovic, Andrew C. Wilson, et al. "Lung function trajectories throughout childhood in survivors of very preterm birth: a longitudinal cohort study." Lancet Child & Adolescent Health 2, no. 5 (2018): 350–59. http://dx.doi.org/10.1016/s2352-4642(18)30064-6.

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43

Aldrich, Thomas K., Madeline Vossbrinck, Rachel Zeig-Owens, et al. "Lung Function Trajectories in World Trade Center-Exposed New York City Firefighters Over 13 Years." Chest 149, no. 6 (2016): 1419–27. http://dx.doi.org/10.1016/j.chest.2015.10.067.

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44

Sanna, Francesca, Francesca Locatelli, Peter D. Sly, et al. "Characterization of lung function trajectories and associated early life predictors in an Australian birth cohort study." ERJ Open Research, February 24, 2022, 00072–2022. http://dx.doi.org/10.1183/23120541.00072-2022.

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BackgroundThere is growing evidence that lung function in early life predicts later lung function. Adverse events over the lifespan might influence an individual's lung function trajectory, resulting in poor respiratory health. The aim of this study is to identify early-life risk factors and their impact on lung function trajectories to prevent long term lung impairments.MethodsOur study included participants from the Raine Study – a prospective pregnancy cohort -with at least two spirometry measurements. Lung function trajectories from the six to 22-year follow-ups were characterised using fi
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45

Zhang, Xian, Andrew R. Gray, and Robert J. Hancox. "Distinct trajectories of lung function from childhood to mid-adulthood." Thorax, March 18, 2024, thorax—2023–220436. http://dx.doi.org/10.1136/thorax-2023-220436.

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RationaleLife course trajectories of lung function development and decline influence the risk for lung disease but are poorly documented.ObjectiveTo document lung function trajectories from childhood to mid-adult life.MethodsWe modelled forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC at ages 9, 11, 13, 15, 18, 21, 26, 32, 38 and 45 years from a population-based cohort using latent profile analysis to identify distinct subgroups of participants with similar lung function trajectories. Regression analyses were used to assess associations between the trajectories,
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46

Okyere, Daniel, Nilakshi Waidyatillake, Dinhi Bui, et al. "1031Predictors of Lung function change over the life course: a systematic review." International Journal of Epidemiology 50, Supplement_1 (2021). http://dx.doi.org/10.1093/ije/dyab168.509.

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Abstract Background Throughout life, lung function increases, peaks, plateaus and declines. These phases can be influenced by several exposures. Despite the growing body of evidence, the association between these factors and lung function change over the lif course has not been systematically reviewed. Methods Using a pre-defined protocol, two authors independently identified publications related to lung function trajectories and extracted relevant information. We included studies that identified/developed/modelled/reported lung function trajectories based on at least three-time points. Due to
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47

Abramson, Michael J., and Deborah C. Glass. "Trajectories of lung function in urban firefighters." Respirology, November 27, 2022. http://dx.doi.org/10.1111/resp.14418.

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48

"Lung-Function Trajectories and Chronic Obstructive Pulmonary Disease." New England Journal of Medicine 373, no. 16 (2015): 1574–75. http://dx.doi.org/10.1056/nejmc1510089.

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49

Yammine, Sophie, and Philipp Latzin. "Lung function trajectories and determinants in early life." Lancet Child & Adolescent Health, April 2024. http://dx.doi.org/10.1016/s2352-4642(24)00081-6.

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50

Sunny, Shadia Khan, Hongmei Zhang, Fawaz Mzayek, et al. "Pre-adolescence DNA methylation is associated with lung function trajectories from pre-adolescence to adulthood." Clinical Epigenetics 13, no. 1 (2021). http://dx.doi.org/10.1186/s13148-020-00992-5.

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Abstract Background The pattern of lung function development from pre-adolescence to adulthood plays a significant role in the pathogenesis of respiratory diseases. Inconsistent findings in genetic studies on lung function trajectories, the importance of DNA methylation (DNA-M), and the critical role of adolescence in lung function development motivated the present study of pre-adolescent DNA-M with lung function trajectories. This study investigated epigenome-wide associations of DNA-M at cytosine-phosphate-guanine dinucleotide sites (CpGs) at childhood with lung function trajectories from ch
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