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Journal articles on the topic 'Lung Stem Cell'

Author: Grafiati

Published: 11 March 2023

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1

Kim, Carla F. "Paving the road for lung stem cell biology: bronchioalveolar stem cells and other putative distal lung stem cells." American Journal of Physiology-Lung Cellular and Molecular Physiology 293, no. 5 (2007): L1092—L1098. http://dx.doi.org/10.1152/ajplung.00015.2007.

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New discoveries in stem cell biology are making the biology of solid tissues increasingly complex. Important seminal studies demonstrating the presence of damage-resistant cell populations together with new isolation and characterization techniques suggest that stem cells exist in the adult lung. More detailed in vivo molecular and cellular characterization of bronchioalveolar stem cells (BASCs), other putative lung stem and progenitor cells, and differentiated cells is needed to determine the lineage relationships in adult lung. Lung diseases such as cystic fibrosis or chronic obstructive pul

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2

Sentek, Hanna, and Diana Klein. "Lung-Resident Mesenchymal Stem Cell Fates within Lung Cancer." Cancers 13, no. 18 (2021): 4637. http://dx.doi.org/10.3390/cancers13184637.

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Lung-resident mesenchymal stem cells (LR-MSCs) are non-hematopoietic multipotent stromal cells that predominately reside adventitial within lung blood vessels. Based on their self-renewal and differentiation properties, LR-MSCs turned out to be important regulators of normal lung homeostasis. LR-MSCs exert beneficial effects mainly by local secretion of various growth factors and cytokines that in turn foster pulmonary regeneration including suppression of inflammation. At the same time, MSCs derived from various tissues of origins represent the first choice of cells for cell-based therapeutic

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3

Ionescu, Lavinia, Roisin N. Byrne, Tim van Haaften, et al. "Stem cell conditioned medium improves acute lung injury in mice: in vivo evidence for stem cell paracrine action." American Journal of Physiology-Lung Cellular and Molecular Physiology 303, no. 11 (2012): L967—L977. http://dx.doi.org/10.1152/ajplung.00144.2011.

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Mortality and morbidity of acute lung injury and acute respiratory distress syndrome remain high because of the lack of pharmacological therapies to prevent injury or promote repair. Mesenchymal stem cells (MSCs) prevent lung injury in various experimental models, despite a low proportion of donor-derived cell engraftment, suggesting that MSCs exert their beneficial effects via paracrine mechanisms. We hypothesized that soluble factors secreted by MSCs promote the resolution of lung injury in part by modulating alveolar macrophage (AM) function. We tested the therapeutic effect of MSC-derived

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4

Kuo, Ming-Han, Pei-Yu Chen, Yi-Ping Yang, et al. "Cytokine and Epigenetic Regulation of Programmed Death-Ligand 1 in Stem Cell Differentiation and Cancer Cell Plasticity." Stem Cells 39, no. 10 (2021): 1298–309. http://dx.doi.org/10.1002/stem.3429.

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Abstract Programmed death-ligand 1 (PD-L1), an immune checkpoint ligand, is recognized as a potential target for cancer immunotherapy as well as for the induction of transplantation tolerance. However, how the crosstalk between stem cell programming and cytokine signaling regulates PD-L1 expression during stem cell differentiation and cancer cell plasticity remains unclear. Herein, we reported that PD-L1 expression was regulated by SOX2 during embryonic stem cell (ESC) differentiation and lung cancer cell plasticity. PD-L1 was induced during ESC differentiation to fibroblasts and was downregul

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5

Kotton, Darrell N., and Alan Fine. "Lung stem cells." Cell and Tissue Research 331, no. 1 (2007): 145–56. http://dx.doi.org/10.1007/s00441-007-0479-2.

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6

Omar, Said A., Amal Abdul-Hafez, Sherif Ibrahim, et al. "Stem-Cell Therapy for Bronchopulmonary Dysplasia (BPD) in Newborns." Cells 11, no. 8 (2022): 1275. http://dx.doi.org/10.3390/cells11081275.

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Premature newborns are at a higher risk for the development of respiratory distress syndrome (RDS), acute lung injury (ALI) associated with lung inflammation, disruption of alveolar structure, impaired alveolar growth, lung fibrosis, impaired lung angiogenesis, and development of bronchopulmonary dysplasia (BPD) with severe long-term developmental adverse effects. The current therapy for BPD is limited to supportive care including high-oxygen therapy and pharmacotherapy. Recognizing more feasible treatment options to improve lung health and reduce complications associated with BPD is essential

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7

Wu, Huijuan, and Nan Tang. "Stem cells in pulmonary alveolar regeneration." Development 148, no. 2 (2021): dev193458. http://dx.doi.org/10.1242/dev.193458.

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ABSTRACTThe lungs are constantly exposed to the external environment and are therefore vulnerable to insults that can cause infection and injury. Maintaining the integrity and barrier function of the lung epithelium requires complex interactions of multiple cell lineages. Elucidating the cellular players and their regulation mechanisms provides fundamental information to deepen understanding about the responses and contributions of lung stem cells. This Review focuses on advances in our understanding of mammalian alveolar epithelial stem cell subpopulations and discusses insights about the reg

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8

OTTO, W. R. "Lung stem cells." International Journal of Experimental Pathology 78, no. 5 (2003): 291–310. http://dx.doi.org/10.1046/j.1365-2613.1997.370366.x.

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9

MAIUTHED, ARNATCHAI, WIPA CHANTARAWONG, and PITHI CHANVORACHOTE. "Lung Cancer Stem Cells and Cancer Stem Cell-targeting Natural Compounds." Anticancer Research 38, no. 7 (2018): 3797–809. http://dx.doi.org/10.21873/anticanres.12663.

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10

Yin, Huijing, Bo Jing, Dongliang Xu, et al. "Identification of Active Bronchioalveolar Stem Cells as the Cell of Origin in Lung Adenocarcinoma." Cancer Research 82, no. 6 (2022): 1025–37. http://dx.doi.org/10.1158/0008-5472.can-21-2445.

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Abstract While initiation is established as a critical step in tumorigenesis, the identity of the cell of origin for lung adenocarcinoma and the mechanism controlling susceptibility to initiation remain elusive. Here we show that lung tumor suppressor Gprc5a-knockout (KO) mice are susceptible to initiation of lung tumorigenesis. Bronchioalveolar stem cells (BASC) and alveolar type 2 (AT2) cells were aberrantly expanded in Gprc5a-KO mouse lungs compared with those in wild-type (WT) mice, suggesting that Gprc5a-KO might confer susceptibility to initiation by increasing the cell of origin in mous

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11

Weiss, D. J., J. K. Kolls, L. A. Ortiz, A. Panoskaltsis-Mortari, and D. J. Prockop. "Stem Cells and Cell Therapies in Lung Biology and Lung Diseases." Proceedings of the American Thoracic Society 5, no. 5 (2008): 637–67. http://dx.doi.org/10.1513/pats.200804-037dw.

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12

Weiss, D. J., I. Bertoncello, Z. Borok, et al. "Stem Cells and Cell Therapies in Lung Biology and Lung Diseases." Proceedings of the American Thoracic Society 8, no. 3 (2011): 223–72. http://dx.doi.org/10.1513/pats.201012-071dw.

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13

Parekh, Kalpaj R., Janna Nawroth, Albert Pai, Shana M. Busch, Christiana N. Senger, and Amy L. Ryan. "Stem cells and lung regeneration." American Journal of Physiology-Cell Physiology 319, no. 4 (2020): C675—C693. http://dx.doi.org/10.1152/ajpcell.00036.2020.

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The ability to replace defective cells in an airway with cells that can engraft, integrate, and restore a functional epithelium could potentially cure a number of lung diseases. Progress toward the development of strategies to regenerate the adult lung by either in vivo or ex vivo targeting of endogenous stem cells or pluripotent stem cell derivatives is limited by our fundamental lack of understanding of the mechanisms controlling human lung development, the precise identity and function of human lung stem and progenitor cell types, and the genetic and epigenetic control of human lung fate. I

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14

Trounson, Alan, Kyle Kolaja, Thomas Petersen, Klaus Weber, Maralee McVean, and Kathleen A. Funk. "Stem Cell Research." International Journal of Toxicology 34, no. 4 (2015): 349–51. http://dx.doi.org/10.1177/1091581815581423.

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Stem cells have great potential in basic research and are being slowly integrated into toxicological research. This symposium provided an overview of the state of the field, stem cell models, described allogenic stem cell treatments and issues of immunogenicity associated with protein therapeutics, and tehn concentrated on stem cell uses in regenerative medicine focusing on lung and testing strategies on engineered tissues from a pathologist’s perspective.

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15

Haddad, Imad Y. "Stem cell transplantation and lung dysfunction." Current Opinion in Pediatrics 25, no. 3 (2013): 350–56. http://dx.doi.org/10.1097/mop.0b013e328360c317.

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16

Purnell, Beverly A. "Fibroblasts as lung stem cell niche." Science 359, no. 6380 (2018): 1114.10–1116. http://dx.doi.org/10.1126/science.359.6380.1114-j.

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17

Schrepfer, S., T. Deuse, H. Reichenspurner, M. P. Fischbein, R. C. Robbins, and M. P. Pelletier. "Stem Cell Transplantation: The Lung Barrier." Transplantation Proceedings 39, no. 2 (2007): 573–76. http://dx.doi.org/10.1016/j.transproceed.2006.12.019.

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18

Pine, Sharon R., Blair Marshall, and Lyuba Varticovski. "Lung Cancer Stem Cells." Disease Markers 24, no. 4-5 (2008): 257–66. http://dx.doi.org/10.1155/2008/396281.

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Lung cancer remains a major cause of cancer-related lethality because of high incidence and recurrence in spite of significant advances in staging and therapies. Recent data indicates that stem cells situated throughout the airways may initiate cancer formation. These putative stem cells maintain protumorigenic characteristics including high proliferative capacity, multipotent differentiation, drug resistance and long lifespan relative to other cells. Stem cell signaling and differentiation pathways are maintained within distinct cancer types, and destabilization of this machinery may particip

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19

Hamad, Hussein, and Birgitte Brinkmann Olsen. "Cannabidiol Induces Cell Death in Human Lung Cancer Cells and Cancer Stem Cells." Pharmaceuticals 14, no. 11 (2021): 1169. http://dx.doi.org/10.3390/ph14111169.

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Currently, there is no effective therapy against lung cancer due to the development of resistance. Resistance contributes to disease progression, recurrence, and mortality. The presence of so-called cancer stem cells could explain the ineffectiveness of conventional treatment, and the development of successful cancer treatment depends on the targeting also of cancer stem cells. Cannabidiol (CBD) is a cannabinoid with anti-tumor properties. However, the effects on cancer stem cells are not well understood. The effects of CBD were evaluated in spheres enriched in lung cancer stem cells and adher

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20

Wagner, Darcy E., Laertis Ikonomou, Sarah E. Gilpin, et al. "Stem Cells, Cell Therapies, and Bioengineering in Lung Biology and Disease 2019." ERJ Open Research 6, no. 4 (2020): 00123–2020. http://dx.doi.org/10.1183/23120541.00123-2020.

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A workshop entitled “Stem Cells, Cell Therapies and Bioengineering in Lung Biology and Diseases” was hosted by the University of Vermont Larner College of Medicine in collaboration with the National Heart, Lung and Blood Institute, the Alpha-1 Foundation, the Cystic Fibrosis Foundation, the International Society for Cell and Gene Therapy and the Pulmonary Fibrosis Foundation. The event was held from July 15 to 18, 2019 at the University of Vermont, Burlington, Vermont. The objectives of the conference were to review and discuss the current status of the following active areas of research: 1) t

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21

Nystedt, Johanna, Heidi Anderson, Jonne Tikkanen, et al. "Cell Surface Structures Influence Lung Clearance Rate of Systemically Infused Mesenchymal Stromal Cells." STEM CELLS 31, no. 2 (2013): 317–26. http://dx.doi.org/10.1002/stem.1271.

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22

Parikh, S. D., V. Levina, T. Wang, M. K. Gibson, and A. E. Lokshin. "Radioresistance of Non-small Cell Lung Cancer Stem Cells." International Journal of Radiation Oncology*Biology*Physics 75, no. 3 (2009): S542—S543. http://dx.doi.org/10.1016/j.ijrobp.2009.07.1240.

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23

Song, Ye Na, and Man Ryul Lee. "Single-cell transcriptomics of lung organoids." Organoid 1 (October 19, 2021): e9. http://dx.doi.org/10.51335/organoid.2021.1.e9.

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The in vitro application of human pluripotent stem cell- or adult stem cell-derived lung organoids has the potential to revolutionize lung disease research, but there are several limitations in the consistent implementation of lung organoids resulting from the structural diversity of the lung tissues and the variety of cell types (more than 40 resident cell types) populating these tissues. However, the evaluation of these complexities using a combination of lung organoids and single-cell transcriptomics has made it possible to identify several key cell types and sub-populations critical to the

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24

Elias, Anthony. "Hematopoietic Stem Cell Transplantation for Small Cell Lung Cancer." Chest 116 (December 1999): 531S—538S. http://dx.doi.org/10.1378/chest.116.suppl_3.531s.

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25

Rizzo, J. Douglas, Anthony D. Elias, Patrick J. Stiff, et al. "Autologous stem cell transplantation for small cell lung cancer." Biology of Blood and Marrow Transplantation 8, no. 5 (2002): 273–80. http://dx.doi.org/10.1053/bbmt.2002.v8.pm12064365.

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26

Tachezy, Michael, Hilke Zander, Gerrit Wolters-Eisfeld, et al. "Activated Leukocyte Cell Adhesion Molecule (CD166): An “Inert” Cancer Stem Cell Marker for Non-Small Cell Lung Cancer?" STEM CELLS 32, no. 6 (2014): 1429–36. http://dx.doi.org/10.1002/stem.1665.

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27

Yamashita, Naoki, Tetsuya So, Takeaki Miyata, et al. "Cancer stem cell markers in lung adenocarcinoma." Personalized Medicine Universe 9 (October 31, 2020): 64–65. http://dx.doi.org/10.46459/pmu.2020002.

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28

Cruz, Fernanda F., and Patricia R. M. Rocco. "Stem-cell extracellular vesicles and lung repair." Stem Cell Investigation 4, no. 9 (2017): 78. http://dx.doi.org/10.21037/sci.2017.09.02.

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29

Whitson, Bryan A., Ryan C. Shelstad, Marshall I. Hertz, Rosemary F. Kelly, Jonathan D’Cunha, and Sara J. Shumway. "Lung transplantation after hematopoietic stem cell transplantation." Clinical Transplantation 26, no. 2 (2011): 254–58. http://dx.doi.org/10.1111/j.1399-0012.2011.01482.x.

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30

Tzouvelekis, Argyris, Paschalis Ntolios, and Demosthenes Bouros. "Stem Cell Treatment for Chronic Lung Diseases." Respiration 85, no. 3 (2013): 179–92. http://dx.doi.org/10.1159/000346525.

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31

Miyata, Takeaki, Takashi Yoshimatsu, Tetsuya So, et al. "Cancer stem cell markers in lung cancer." Personalized Medicine Universe 4 (July 2015): 40–45. http://dx.doi.org/10.1016/j.pmu.2015.03.007.

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32

Koch, Lin-Kristin, Hui Zhou, Jörg Ellinger, et al. "Stem cell marker expression in small cell lung carcinoma and developing lung tissue." Human Pathology 39, no. 11 (2008): 1597–605. http://dx.doi.org/10.1016/j.humpath.2008.03.008.

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33

Xing, Dongqi, J. Michael Wells, Samantha S. Giordano, et al. "Induced pluripotent stem cell-derived endothelial cells attenuate lipopolysaccharide-induced acute lung injury." Journal of Applied Physiology 127, no. 2 (2019): 444–56. http://dx.doi.org/10.1152/japplphysiol.00587.2018.

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The chemokine receptors CXCR1/2 and CCR2/5 play a critical role in neutrophil and monocyte recruitment to sites of injury and/or inflammation. Neutrophil-mediated inflammation and endothelial cell (EC) injury are unifying factors in the pathogenesis of the acute respiratory distress syndrome. This study tested the hypothesis that systemic administration of rat-induced pluripotent stem cell (iPS)-derived ECs (iPS-ECs) overexpressing CXCR1/2 or CCR2/5 attenuates lipopolysaccharide (LPS)-induced acute lung injury. Rat iPS-ECs were transduced with adenovirus containing cDNA of CXCR1/2 or CCR2/5. O

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34

Rasky, Andrew, David M. Habiel, Susan Morris, et al. "Inhibition of the stem cell factor 248 isoform attenuates the development of pulmonary remodeling disease." American Journal of Physiology-Lung Cellular and Molecular Physiology 318, no. 1 (2020): L200—L211. http://dx.doi.org/10.1152/ajplung.00114.2019.

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Stem cell factor (SCF) and its receptor c-kit have been implicated in inflammation, tissue remodeling, and fibrosis. Ingenuity Integrated Pathway Analysis of gene expression array data sets showed an upregulation of SCF transcripts in idiopathic pulmonary fibrosis (IPF) lung biopsies compared with tissue from nonfibrotic lungs that are further increased in rapid progressive disease. SCF248, a cleavable isoform of SCF, was abundantly and preferentially expressed in human lung fibroblasts and fibrotic mouse lungs relative to the SCF220 isoform. In fibroblast-mast cell coculture studies, blockade

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35

Pacienza, Natalia, Diego Santa-Cruz, Ricardo Malvicini, et al. "Mesenchymal Stem Cell Therapy Facilitates Donor Lung Preservation by Reducing Oxidative Damage during Ischemia." Stem Cells International 2019 (August 5, 2019): 1–13. http://dx.doi.org/10.1155/2019/8089215.

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Lung transplantation is a lifesaving therapy for people living with severe, life-threatening lung disease. The high mortality rate among patients awaiting transplantation is mainly due to the low percentage of lungs that are deemed acceptable for implantation. Thus, the current shortage of lung donors may be significantly reduced by implementing different therapeutic strategies which facilitate both organ preservation and recovery. Here, we studied whether the anti-inflammatory effect of human umbilical cord-derived mesenchymal stem cells (HUCPVCs) increases lung availability by improving orga

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36

Hennrick, Kenneth T., Angela G. Keeton, Suparna Nanua, et al. "Lung Cells from Neonates Show a Mesenchymal Stem Cell Phenotype." American Journal of Respiratory and Critical Care Medicine 175, no. 11 (2007): 1158–64. http://dx.doi.org/10.1164/rccm.200607-941oc.

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37

Martin, J., K. Helm, P. Ruegg, M. Varella-Garcia, E. Burnham, and S. Majka. "Adult lung side population cells have mesenchymal stem cell potential." Cytotherapy 10, no. 2 (2008): 140–51. http://dx.doi.org/10.1080/14653240801895296.

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38

Ouyang, Xiaoping, Xinlin Shi, Na Huang та ін. "WDR72 Enhances the Stemness of Lung Cancer Cells by Activating the AKT/HIF-1α Signaling Pathway". Journal of Oncology 2022 (7 листопада 2022): 1–12. http://dx.doi.org/10.1155/2022/5059588.

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Objectives. Lung cancer is a common malignant tumor with high morbidity and mortality rate. Lung cancer stem cells are crucial in the development of lung cancer. In this study, we investigate WD repeat-containing protein 72 (WDR72) on lung cancer cell stemness and explore its underlying mechanism. Methods. WDR72 expression was investigated in lung cancer tissues and lung cancer stem cells by Western blot and RT-qPCR. The stemness of lung cancer stem cells was verified by the sphere-forming experiment and the abundance of stem cell markers. For the purpose of determining lung cancer stem cell g

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39

Inamdar, Ajinkya C., and Arati A. Inamdar. "Mesenchymal stem cell therapy in lung disorders: Pathogenesis of lung diseases and mechanism of action of mesenchymal stem cell." Experimental Lung Research 39, no. 8 (2013): 315–27. http://dx.doi.org/10.3109/01902148.2013.816803.

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40

Kotton, Darrell N., Ross Summer, and Alan Fine. "Lung stem cells: New paradigms." Experimental Hematology 32, no. 4 (2004): 340–43. http://dx.doi.org/10.1016/j.exphem.2004.01.009.

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41

Alder, Jonathan K., Christina E. Barkauskas, Nathachit Limjunyawong, et al. "Telomere dysfunction causes alveolar stem cell failure." Proceedings of the National Academy of Sciences 112, no. 16 (2015): 5099–104. http://dx.doi.org/10.1073/pnas.1504780112.

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Telomere syndromes have their most common manifestation in lung disease that is recognized as idiopathic pulmonary fibrosis and emphysema. In both conditions, there is loss of alveolar integrity, but the underlying mechanisms are not known. We tested the capacity of alveolar epithelial and stromal cells from mice with short telomeres to support alveolar organoid colony formation and found that type 2 alveolar epithelial cells (AEC2s), the stem cell-containing population, were limiting. When telomere dysfunction was induced in adult AEC2s by conditional deletion of the shelterin component telom

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42

Nacarino-Palma, Ana, Claudia M. Rejano-Gordillo, Francisco J. González-Rico, et al. "Loss of Aryl Hydrocarbon Receptor Favors K-RasG12D-Driven Non-Small Cell Lung Cancer." Cancers 13, no. 16 (2021): 4071. http://dx.doi.org/10.3390/cancers13164071.

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Non-small cell lung adenocarcinoma (NSCLC) bearing K-RasG12D mutations is one of the most prevalent types of lung cancer worldwide. Aryl hydrocarbon receptor (AHR) expression varies in human lung tumors and has been associated with either increased or reduced lung metastasis. In the mouse, Ahr also adjusts lung regeneration upon injury by limiting the expansion of resident stem cells. Here, we show that the loss of Ahr enhances K-RasG12D-driven NSCLC in mice through the amplification of stem cell subpopulations. Consistent with this, we show that K-RasG12D;Ahr−/− lungs contain larger numbers o

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43

Savukinas, Ulrika Blank, Sara Rolandsson Enes, Annika Andersson Sjöland, and Gunilla Westergren-Thorsson. "Concise Review: The Bystander Effect: Mesenchymal Stem Cell-Mediated Lung Repair." STEM CELLS 34, no. 6 (2016): 1437–44. http://dx.doi.org/10.1002/stem.2357.

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44

Li, Feng, Jinxi He, Jun Wei, William C. Cho, and Xiaoming Liu. "Diversity of Epithelial Stem Cell Types in Adult Lung." Stem Cells International 2015 (2015): 1–11. http://dx.doi.org/10.1155/2015/728307.

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Lung is a complex organ lined with epithelial cells. In order to maintain its homeostasis and normal functions following injuries caused by varied extraneous and intraneous insults, such as inhaled environmental pollutants and overwhelming inflammatory responses, the respiratory epithelium normally undergoes regenerations by the proliferation and differentiation of region-specific epithelial stem/progenitor cells that resided in distinct niches along the airway tree. The importance of local epithelial stem cell niches in the specification of lung stem/progenitor cells has been recently identif

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45

Pan, Zhenhua, Meidi Zhang, Fengyu Zhang, et al. "Single-Cell Transcriptomics Unveils the Dedifferentiation Mechanism of Lung Adenocarcinoma Stem Cells." International Journal of Molecular Sciences 24, no. 1 (2022): 482. http://dx.doi.org/10.3390/ijms24010482.

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Lung adenocarcinoma (LUAD) is a major subtype of lung cancer, and its prognosis is still poor due to therapy resistance, metastasis, and recurrence. In recent years, increasing evidence has shown that the existence of lung cancer stem cells is responsible for the propagation, metastasis, therapy resistance, and recurrence of the tumor. During their transition to cancer stem cells, tumor cells need to inhibit cell differentiation and acquire invasive characteristics. However, our understanding of the property and role of such lung cancer stem cells is still limited. In this study, lung adenocar

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46

Tropea, Kristen A., Eva Leder, Muhammad Aslam, et al. "Bronchioalveolar stem cells increase after mesenchymal stromal cell treatment in a mouse model of bronchopulmonary dysplasia." American Journal of Physiology-Lung Cellular and Molecular Physiology 302, no. 9 (2012): L829—L837. http://dx.doi.org/10.1152/ajplung.00347.2011.

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Bronchopulmonary dysplasia (BPD) remains a major complication of prematurity resulting in significant morbidity and mortality. The pathology of BPD is multifactorial and leads to alveolar simplification and distal lung injury. Previous studies have shown a beneficial effect of systemic treatment with bone marrow-derived mesenchymal stromal cells (MSCs) and MSC-conditioned media (MSC-CM) leading to amelioration of the lung parenchymal and vascular injury in vivo in the hyperoxia murine model of BPD. It is possible that the beneficial response from the MSCs is at least in part due to activation

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47

Pitt, Bruce R., and Luis A. Ortiz. "Stem cells in lung biology." American Journal of Physiology-Lung Cellular and Molecular Physiology 286, no. 4 (2004): L621—L623. http://dx.doi.org/10.1152/ajplung.00392.2003.

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48

Abreu, Soraia Carvalho, Tatiana Maron-Gutierrez, Cristiane Sousa Nascimento Baez Garcia, Marcelo Marcos Morales, and Patricia Rieken Macedo Rocco. "Stem cells and respiratory diseases." Brazilian Archives of Biology and Technology 51, spe (2008): 23–30. http://dx.doi.org/10.1590/s1516-89132008000700005.

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Stem cells have a multitude of clinical implications in the lung. This article is a critical review that includes clinical and experimental studies of MedLine and SciElo database in the last 10 years, where we highlight the effects of stem cell therapy in acute respiratory distress syndrome or more chronic disorders such as lung fibrosis and emphysema. Although, many studies have shown the beneficial effects of stem cells in lung development, repair and remodeling; some important questions need to be answered to better understand the mechanisms that control cell division and differentiation, t

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49

Song, Na, Hiroaki Wakimoto, Filippo Rossignoli, et al. "Mesenchymal stem cell immunomodulation: In pursuit of controlling COVID-19 related cytokine storm." Stem Cells 39, no. 6 (2021): 707–22. http://dx.doi.org/10.1002/stem.3354.

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Abstract The coronavirus disease 2019 (COVID-19) pandemic has grown to be a global public health crisis with no safe and effective treatments available yet. Recent findings suggest that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the coronavirus pathogen that causes COVID-19, could elicit a cytokine storm that drives edema, dysfunction of the airway exchange, and acute respiratory distress syndrome in the lung, followed by acute cardiac injury and thromboembolic events leading to multiorgan failure and death. Mesenchymal stem cells (MSCs), owing to their powerful immunomodula

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50

Shaykhiev, Renat, Rui Wang, Rachel K. Zwick, et al. "Airway basal cells of healthy smokers express an embryonic stem cell signature relevant to lung cancer." STEM CELLS 31, no. 9 (2013): 1992–2002. http://dx.doi.org/10.1002/stem.1459.

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