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Journal articles on the topic 'Lung ventilation estimation'

Author: Grafiati

Published: 4 June 2021

Last updated: 10 February 2022

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1

Oruganti Venkata, Sanjay Sarma, Amie Koenig, and Ramana M. Pidaparti. "Mechanical Ventilator Parameter Estimation for Lung Health through Machine Learning." Bioengineering 8, no. 5 (2021): 60. http://dx.doi.org/10.3390/bioengineering8050060.

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Patients whose lungs are compromised due to various respiratory health concerns require mechanical ventilation for support in breathing. Different mechanical ventilation settings are selected depending on the patient’s lung condition, and the selection of these parameters depends on the observed patient response and experience of the clinicians involved. To support this decision-making process for clinicians, good prediction models are always beneficial in improving the setting accuracy, reducing treatment error, and quickly weaning patients off the ventilation support. In this study, we devel

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2

Hartford, Craig G., Johan M. van Schalkwyk, Geoffrey G. Rogers, and Martin J. Turner. "Primate Pleuroesophageal Tissue Barrier Frequency Response and Esophageal Pressure Waveform Bandwidth in Health and Acute Lung Injury." Anesthesiology 92, no. 2 (2000): 550. http://dx.doi.org/10.1097/00000542-200002000-00039.

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Background Dynamic intraesophageal pressure (Pes) is used to estimate intrapleural pressure (Ppl) to calculate lung compliance and resistance. This study investigated the nonhuman primate Ppl-Pes tissue barrier frequency response and the dynamic response requirements of Pes manometers. Methods In healthy monkeys and monkeys with acute lung injury undergoing ventilation, simultaneous Ppl and Pes were measured directly to determine the Ppl-Pes tissue barrier amplitude frequency response, using the swept-sine wave technique. The bandwidths of physiologic Pes waveforms acquired during conventional

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Verbanck, Sylvia, Daniel Schuermans, Sophie Van Malderen, Walter Vincken, and Bruce Thompson. "The effect of conductive ventilation heterogeneity on diffusing capacity measurement." Journal of Applied Physiology 104, no. 4 (2008): 1094–100. http://dx.doi.org/10.1152/japplphysiol.00917.2007.

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It has long been assumed that the ventilation heterogeneity associated with lung disease could, in itself, affect the measurement of carbon monoxide transfer factor. The aim of this study was to investigate the potential estimation errors of carbon monoxide diffusing capacity (DlCO) measurement that are specifically due to conductive ventilation heterogeneity, i.e., due to a combination of ventilation heterogeneity and flow asynchrony between lung units larger than acini. We induced conductive airway ventilation heterogeneity in 35 never-smoker normal subjects by histamine provocation and rela

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FUJII, Tadashige, Hisakata KANAI, Jiro HIRAYAMA, Kenjiro HANDA, Shozo KUSAMA, and Kesato YANO. "Estimation of regional pulmonary ventilation using perfusion lung scintigram." RADIOISOTOPES 37, no. 4 (1988): 209–16. http://dx.doi.org/10.3769/radioisotopes.37.4_209.

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5

Rubin, Jonathan, Jeffrey Horowitz, Thomas Sisson, Kang Kim, and James Hamilton. "2080299 Local Lung Ventilation Estimation Using Ultrasound Strain Measurements." Ultrasound in Medicine & Biology 41, no. 4 (2015): S83—S84. http://dx.doi.org/10.1016/j.ultrasmedbio.2014.12.343.

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6

Szmul, Adam, Tahreema Matin, Fergus V. Gleeson, Julia A. Schnabel, Vicente Grau, and Bartłomiej W. Papież. "Patch-based lung ventilation estimation using multi-layer supervoxels." Computerized Medical Imaging and Graphics 74 (June 2019): 49–60. http://dx.doi.org/10.1016/j.compmedimag.2019.04.002.

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7

Hamahata, Natsumi, Ryota Sato, Kimiyo Yamasaki, Sophie Pereira, and Ehab Daoud. "Estimating actual inspiratory muscle pressure from airway occlusion pressure at 100 msec." Journal of Mechanical Ventilation 1, no. 1 (2020): 8–13. http://dx.doi.org/10.53097/jmv.10003.

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Background: Quantification of the patient’s respiratory effort during mechanical ventilation is very important, and calculating the actual muscle pressure (Pmus) during mechanical ventilation is a cumbersome task and usually requires an esophageal balloon manometry. Airway occlusion pressure at 100 milliseconds (P0.1) can easily be obtained non-invasively. There has been no study investigating the association between Pmus and P0.1. Therefore, we aimed to investigate whether P0.1 correlates to Pmus and can be used to estimate actual Pmus Materials and Methods: A bench study using lung simulator

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Webb, Jeffrey B., Aaron Bray, Philip K. Asare, et al. "Computational simulation to assess patient safety of uncompensated COVID-19 two-patient ventilator sharing using the Pulse Physiology Engine." PLOS ONE 15, no. 11 (2020): e0242532. http://dx.doi.org/10.1371/journal.pone.0242532.

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Background The COVID-19 pandemic is stretching medical resources internationally, sometimes creating ventilator shortages that complicate clinical and ethical situations. The possibility of needing to ventilate multiple patients with a single ventilator raises patient health and safety concerns in addition to clinical conditions needing treatment. Wherever ventilators are employed, additional tubing and splitting adaptors may be available. Adjustable flow-compensating resistance for differences in lung compliance on individual limbs may not be readily implementable. By exploring a number and r

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9

Matejka, Jan, Martin Rozanek, Jakub Rafl, Petr Kudrna, and Karel Roubik. "In Vitro Estimation of Relative Compliance during High-Frequency Oscillatory Ventilation." Applied Sciences 11, no. 3 (2021): 899. http://dx.doi.org/10.3390/app11030899.

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High-frequency oscillatory ventilation (HFOV), which uses a small tidal volume and a high respiratory rate, is considered a type of protective lung ventilation that can be beneficial for certain patients. A disadvantage of HFOV is its limited monitoring of lung mechanics, which complicates its settings and optimal adjustment. Recent studies have shown that respiratory system reactance (Xrs) could be a promising parameter in the evaluation of respiratory system mechanics in HFOV. The aim of this study was to verify in vitro that a change in respiratory system mechanics during HFOV can be monito

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10

Heinrich, H. P., M. Jenkinson, M. Brady, and J. A. Schnabel. "MRF-Based Deformable Registration and Ventilation Estimation of Lung CT." IEEE Transactions on Medical Imaging 32, no. 7 (2013): 1239–48. http://dx.doi.org/10.1109/tmi.2013.2246577.

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11

Prisk, G. K., and A. E. McKinnon. "Estimation of amount of stationary pulmonary blood from carbon monoxide uptake measurements." Journal of Applied Physiology 63, no. 3 (1987): 1303–8. http://dx.doi.org/10.1152/jappl.1987.63.3.1303.

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A mathematical model of CO uptake from a single alveolus is modified to include stationary pulmonary blood arising from a pulmonary vascular obstruction. From this model an estimator model is developed that produces simultaneous estimations of the diffusing capacity of the lung for CO and the fraction of the pulmonary capillary blood that is stationary. The estimator model was tested using simulated data from uniform and non-uniform simulators and found to be only mildly sensitive to noise and incorrect values for the pulmonary capillary blood volume. Both the estimator model and breath-to-bre

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12

Suki, B., and J. H. Bates. "A nonlinear viscoelastic model of lung tissue mechanics." Journal of Applied Physiology 71, no. 3 (1991): 826–33. http://dx.doi.org/10.1152/jappl.1991.71.3.826.

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There have been a number of attempts recently to use linear models to describe the low-frequency (0–2 Hz) dependence of lung tissue resistance (Rti) and elastance (Eti). Only a few attempts, however, have been made to account for the volume dependence of these quantities, all of which require the tissues to be plastoelastic. In this paper we specifically avoid invoking plastoelasticity and develop a nonlinear viscoelastic model that is also capable of accounting for the nonlinear and frequency-dependent features of lung tissue mechanics. The model parameters were identified by fitting the mode

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13

Mokra, D., P. Mikolka, P. Kosutova, et al. "Effects of Conventional Mechanical Ventilation Performed by Two Neonatal Ventilators on the Lung Functions of Rabbits with Meconium-Induced Acute Lung Injury." Acta Medica Martiniana 16, no. 3 (2016): 5–13. http://dx.doi.org/10.1515/acm-2016-0012.

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AbstractSevere meconium aspiration syndrome (MAS) in the neonates often requires a ventilatory support. As a method of choice, a conventional mechanical ventilation with small tidal volumes (VT<6 ml/kg) and appropriate ventilatory pressures is used. The purpose of this study was to assess the short-term effects of the small-volume CMV performed by two neonatal ventilators: Aura V (Chirana Stara Tura a.s., Slovakia) and SLE5000 (SLE Ltd., UK) on the lung functions of rabbits with experimentally-induced MAS and to estimate whether the newly developed neonatal version of the ventilator Aura V

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14

Wang, Miao, Quan Gong, and Wei Wei. "Estimation of shunt fraction by transesophageal echocardiography during one-lung ventilation." Journal of Clinical Monitoring and Computing 29, no. 2 (2014): 307–11. http://dx.doi.org/10.1007/s10877-014-9606-2.

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15

Chen, Zheng-long, Yuan-lin Song, Zhao-yan Hu, Su Zhang, and Ya-zhu Chen. "An estimation of mechanical stress on alveolar walls during repetitive alveolar reopening and closure." Journal of Applied Physiology 119, no. 3 (2015): 190–201. http://dx.doi.org/10.1152/japplphysiol.00112.2015.

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Alveolar overdistension and mechanical stresses generated by repetitive opening and closing of small airways and alveoli have been widely recognized as two primary mechanistic factors that may contribute to the development of ventilator-induced lung injury. A long-duration exposure of alveolar epithelial cells to even small, shear stresses could lead to the changes in cytoskeleton and the production of inflammatory mediators. In this paper, we have made an attempt to estimate in situ the magnitudes of mechanical stresses exerted on the alveolar walls during repetitive alveolar reopening by usi

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16

Scharm, Sarah C., Jens Vogel-Claussen, Cornelia Schaefer-Prokop, et al. "Quantification of dual-energy CT-derived functional parameters as potential imaging markers for progression of idiopathic pulmonary fibrosis." European Radiology 31, no. 9 (2021): 6640–51. http://dx.doi.org/10.1007/s00330-021-07798-w.

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Abstract Objectives The individual course of disease in idiopathic pulmonary fibrosis (IPF) is highly variable. Assessment of disease activity and prospective estimation of disease progression might have the potential to improve therapy management and indicate the onset of treatment at an earlier stage. The aim of this study was to evaluate whether regional ventilation, lung perfusion, and late enhancement can serve as early imaging markers for disease progression in patients with IPF. Methods In this retrospective study, contrast-enhanced dual-energy CT scans of 32 patients in inspiration and

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17

Dubsky, Stephen, Stuart B. Hooper, Karen K. W. Siu, and Andreas Fouras. "Synchrotron-based dynamic computed tomography of tissue motion for regional lung function measurement." Journal of The Royal Society Interface 9, no. 74 (2012): 2213–24. http://dx.doi.org/10.1098/rsif.2012.0116.

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During breathing, lung inflation is a dynamic process involving a balance of mechanical factors, including trans-pulmonary pressure gradients, tissue compliance and airway resistance. Current techniques lack the capacity for dynamic measurement of ventilation in vivo at sufficient spatial and temporal resolution to allow the spatio-temporal patterns of ventilation to be precisely defined. As a result, little is known of the regional dynamics of lung inflation, in either health or disease. Using fast synchrotron-based imaging (up to 60 frames s −1 ), we have combined dynamic computed tomography

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18

Babb, T. G., and J. R. Rodarte. "Estimation of ventilatory capacity during submaximal exercise." Journal of Applied Physiology 74, no. 4 (1993): 2016–22. http://dx.doi.org/10.1152/jappl.1993.74.4.2016.

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There is presently no precise way to determine ventilatory capacity for a given individual during exercise; however, this information would be helpful in evaluating ventilatory reserve during exercise. Using schematic representations of maximal expiratory flow-volume curves and individual maximal expiratory flow-volume curves from four subjects, we describe a technique for estimating ventilatory capacity. In these subjects, we measured maximal expiratory flow-volume loops at rest and tidal flow-volume loops and inspiratory capacity (IC) during submaximal cycle ergometry. We also compared minut

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19

Dudley, N. J., K. Griffith, G. P. McGill, and A. T. Rogers. "The estimation of administered activity of krypton-81 m for lung ventilation studies." European Journal of Nuclear Medicine 22, no. 4 (1995): 335–38. http://dx.doi.org/10.1007/bf00941850.

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20

Latifi, K., W. van Elmpt, T. Dilling, et al. "1157 poster AN INVESTIGATION OF THE DIFFERENCES BETWEEN LOCORE-GIONAL LUNG VENTILATION ESTIMATION METHODS." Radiotherapy and Oncology 99 (May 2011): S431. http://dx.doi.org/10.1016/s0167-8140(11)71279-8.

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21

Sá, Rui Carlos, Amran K. Asadi, Rebecca J. Theilmann, Susan R. Hopkins, G. Kim Prisk, and Chantal Darquenne. "Validating the distribution of specific ventilation in healthy humans measured using proton MR imaging." Journal of Applied Physiology 116, no. 8 (2014): 1048–56. http://dx.doi.org/10.1152/japplphysiol.00982.2013.

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Specific ventilation imaging (SVI) uses proton MRI to quantitatively map the distribution of specific ventilation (SV) in the human lung, using inhaled oxygen as a contrast agent. To validate this recent technique, we compared the quantitative measures of heterogeneity of the SV distribution in a 15-mm sagittal slice of lung obtained in 10 healthy supine subjects, (age 37 ± 10 yr, forced expiratory volume in 1 s 97 ± 7% predicted) using SVI to those obtained in the whole lung from multiple-breath nitrogen washout (MBW). Using the analysis of Lewis et al. (Lewis SM, Evans JW, Jalowayski AA. J A

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22

Zhao, Zhanqi, Daniel Steinmann, Danijela Müller-Zivkovic, et al. "A lung area estimation method for analysis of ventilation inhomogeneity based on electrical impedance tomography." Journal of X-Ray Science and Technology 18, no. 2 (2010): 171–82. http://dx.doi.org/10.3233/xst-2010-0252.

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23

Raphael, David T. "Acoustic reflectometry for estimation of lung gas‐phase volume during partial liquid ventilation in sheep." Journal of the Acoustical Society of America 108, no. 5 (2000): 2549. http://dx.doi.org/10.1121/1.4743456.

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24

Seluyanov, V. N., E. M. Kalinin, G. D. Pack, V. I. Mayevskaya, and A. N. Konrad. "Estimation of the anaerobic threshold from the data on lung ventilation and heart rate variability." Human Physiology 37, no. 6 (2011): 733–37. http://dx.doi.org/10.1134/s0362119711060132.

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25

Ruppertshofen, Heike, Sven Kabus, and Bernd Fischer. "Tensor grid based image registration with application to ventilation estimation on 4D CT lung data." International Journal of Computer Assisted Radiology and Surgery 5, no. 6 (2010): 583–93. http://dx.doi.org/10.1007/s11548-010-0419-6.

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26

Busso, Thierry, and Peter A. Robbins. "Evaluation of estimates of alveolar gas exchange by using a tidally ventilated nonhomogenous lung model." Journal of Applied Physiology 82, no. 6 (1997): 1963–71. http://dx.doi.org/10.1152/jappl.1997.82.6.1963.

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Busso, Thierry, and Peter A. Robbins. Evaluation of estimates of alveolar gas exchange by using a tidally ventilated nonhomogenous lung model. J. Appl. Physiol. 82(6): 1963–1971, 1997.—The purpose of this study was to evaluate algorithms for estimating O2 and CO2 transfer at the pulmonary capillaries by use of a nine-compartment tidally ventilated lung model that incorporated inhomogeneities in ventilation-to-volume and ventilation-to-perfusion ratios. Breath-to-breath O2 and CO2 exchange at the capillary level and at the mouth were simulated by using realistic cyclical breathing patterns to d

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Adasme Jeria, R., M. González Oyarzo, J. Manzanares López, S. Ormeño Cid, and K. Zelada Pellegrin. "P0399 / #980: DYNAMIC THORACO PULMONARY COMPLIANCE ESTIMATION IN NEONATAL LUNG MODELS UNDER HIGH FREQUENCY OSCILLATION VENTILATION." Pediatric Critical Care Medicine 22, Supplement 1 3S (2021): 209. http://dx.doi.org/10.1097/01.pcc.0000739936.85331.05.

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28

Weisiger, K. H., and G. D. Swanson. "Importance of oscillations in alveolar gas concentrations in the analysis of rebreathing data." Journal of Applied Physiology 61, no. 3 (1986): 1104–13. http://dx.doi.org/10.1152/jappl.1986.61.3.1104.

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Cyclic rebreathing of a soluble inert gas can be used to estimate lung tissue volume (Vt) and pulmonary blood flow (Qc). A recently proposed method for analyzing such cyclic data (Respir. Physiol. 48: 255–279, 1982) mathematically assumes that ventilation is a continuous process. However, neglecting the cyclic nature of ventilation may prevent the accurate estimation of Vt and Qc. We evaluated this possibility by simulating the uptake of soluble inert gases during rebreathing using a cyclic model of gas exchange. Under cyclic uptake conditions alveolar gases follow an oscillating time course,

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Mehedi, Ibrahim M., Heidir S. M. Shah, Ubaid M. Al-Saggaf, Rachid Mansouri, and Maamar Bettayeb. "Adaptive Fuzzy Sliding Mode Control of a Pressure-Controlled Artificial Ventilator." Journal of Healthcare Engineering 2021 (June 23, 2021): 1–10. http://dx.doi.org/10.1155/2021/1926711.

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This paper presents the application of adaptive fuzzy sliding mode control (AFSMC) for the respiratory system to assist the patients facing difficulty in breathing. The ventilator system consists of a blower-hose-patient system and patient’s lung model with nonlinear lung compliance. The AFSMC is based on two components: singleton control action and a discontinuous term. The singleton control action is based on fuzzy logic with adjustable tuning parameters to approximate the perfect feedback linearization control. The switching control law based on the sliding mode principle aims to minimize t

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Zhang, Boyang, Fiona B. McDonald, Kevin J. Cummings, Peter B. Frappell, and Richard J. A. Wilson. "Novel method for conscious airway resistance and ventilation estimation in neonatal rodents using plethysmography and a mechanical lung." Respiratory Physiology & Neurobiology 201 (September 2014): 75–83. http://dx.doi.org/10.1016/j.resp.2014.07.004.

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31

Mackay, Fraser C., Robyn G. Roth, Noud van Helmond, and Talia K. Ben-Jacob. "Computed tomography lung volume estimation to facilitate protective mechanical ventilation in a patient with achondroplasia and spina bifida." Anaesthesia and Intensive Care 47, no. 5 (2019): 474–75. http://dx.doi.org/10.1177/0310057x19873003.

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32

Kacperski, K., M. Nunez, and B. F. Hutton. "P20 Data-driven estimation of the attenuation coefficient in lung for attenuation correction of ventilation/perfusion SPECT scans." Nuclear Medicine Communications 27, no. 3 (2006): 303. http://dx.doi.org/10.1097/00006231-200603000-00102.

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33

Carlile, P. V., D. D. Lowery, and B. A. Gray. "Effect of PEEP and type of injury on thermal-dye estimation of pulmonary edema." Journal of Applied Physiology 60, no. 1 (1986): 22–31. http://dx.doi.org/10.1152/jappl.1986.60.1.22.

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We investigated the effect of positive end-expiratory pressure (PEEP) on the extravascular thermal volume of the lung (ETV) determined by the thermal-dye technique in three canine models of pulmonary edema created by injection of alpha-naphthylthiourea (ANTU) or oleic acid (OA) into the pulmonary circulation or intrabronchial instillation of hydrochloric acid (HCl). ETV was determined before, during, and after ventilation with 14 cmH2O PEEP, and final ETV was compared with the extravascular lung mass (ELM) determined postmortem. Final ETV correctly estimated ELM in 12 animals with ANTU injury,

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34

Okuda, Nao, Miyako Kyogoku, Yu Inata, et al. "Estimation of change in pleural pressure in assisted and unassisted spontaneous breathing pediatric patients using fluctuation of central venous pressure: A preliminary study." PLOS ONE 16, no. 3 (2021): e0247360. http://dx.doi.org/10.1371/journal.pone.0247360.

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Background It is important to evaluate the size of respiratory effort to prevent patient self-inflicted lung injury and ventilator-induced diaphragmatic dysfunction. Esophageal pressure (Pes) measurement is the gold standard for estimating respiratory effort, but it is complicated by technical issues. We previously reported that a change in pleural pressure (ΔPpl) could be estimated without measuring Pes using change in CVP (ΔCVP) that has been adjusted with a simple correction among mechanically ventilated, paralyzed pediatric patients. This study aimed to determine whether our method can be

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Bouhemad, Bélaïd, Fabio Ferrari, Kris Leleu, Charlotte Arbelot, Qin Lu, and Jean-Jacques Rouby. "Echocardiographic Doppler Estimation of Pulmonary Artery Pressure in Critically Ill Patients with Severe Hypoxemia." Anesthesiology 108, no. 1 (2008): 55–62. http://dx.doi.org/10.1097/01.anes.0000296067.02462.34.

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Background In spontaneously breathing cardiac patients, pulmonary artery pressure (PAP) can be accurately estimated from the transthoracic Doppler study of pulmonary artery and tricuspid regurgitation blood flows. In critically ill patients on mechanical ventilation for acute lung injury, the interposition of gas between the probe and the heart renders the transthoracic approach problematic. This study was aimed at determining whether the transesophageal approach could offer an alternative. Methods Fifty-one consecutive sedated and ventilated patients with severe hypoxemia (arterial oxygen ten

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Radermacher, P., R. Herigault, B. Teisseire, A. Harf, and F. Lemaire. "Low VA/Q areas: arterial-alveolar N2 difference and multiple inert gas elimination technique." Journal of Applied Physiology 64, no. 5 (1988): 2224–29. http://dx.doi.org/10.1152/jappl.1988.64.5.2224.

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In 16 critically ill patients the arterial-alveolar N2 difference and data from the multiple inert gas elimination technique (MIGET) were compared in the evaluation of the contribution of low alveolar ventilation-perfusion ratio (VA/Q) lung regions (0.005 less than VA/Q less than 0.1) to venous admixture (Qva/QT). The arterial-alveolar N2 difference was determined using a manometric technique for the measurement of the arterial N2 partial pressure (PN2). We adopted a two-compartment model of the lung, one compartment having a VA/Q of approximately 1, the other being open, gas filled, unventila

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Latifi, K., G. Zhang, W. van Elmpt, et al. "SU-D-110-02: Evaluation of the Differences between Locoregional Lung Ventilation Estimation Methods Using a Single Deformable Image Registration Algorithm." Medical Physics 38, no. 6Part3 (2011): 3387. http://dx.doi.org/10.1118/1.3611538.

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Liu, C. H., S. C. Niranjan, J. W. Clark, K. Y. San, J. B. Zwischenberger, and A. Bidani. "Airway mechanics, gas exchange, and blood flow in a nonlinear model of the normal human lung." Journal of Applied Physiology 84, no. 4 (1998): 1447–69. http://dx.doi.org/10.1152/jappl.1998.84.4.1447.

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A model integrating airway/lung mechanics, pulmonary blood flow, and gas exchange for a normal human subject executing the forced vital capacity (FVC) maneuver is presented. It requires as input the intrapleural pressure measured during the maneuver. Selected model-generated output variables are compared against measured data (flow at the mouth, change in lung volume, and expired O2 and CO2concentrations at the mouth). A nonlinear parameter-estimation algorithm is employed to vary selected sensitive model parameters to obtain reasonable least squares fits to the data. This study indicates that

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Mountain, James E., Peter Santer, David P. O’Neill, et al. "Potential for noninvasive assessment of lung inhomogeneity using highly precise, highly time-resolved measurements of gas exchange." Journal of Applied Physiology 124, no. 3 (2018): 615–31. http://dx.doi.org/10.1152/japplphysiol.00745.2017.

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Inhomogeneity in the lung impairs gas exchange and can be an early marker of lung disease. We hypothesized that highly precise measurements of gas exchange contain sufficient information to quantify many aspects of the inhomogeneity noninvasively. Our aim was to explore whether one parameterization of lung inhomogeneity could both fit such data and provide reliable parameter estimates. A mathematical model of gas exchange in an inhomogeneous lung was developed, containing inhomogeneity parameters for compliance, vascular conductance, and dead space, all relative to lung volume. Inputs were res

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40

Morton, Sophie, Paul Docherty, Jennifer Dickson, and J. Geoffrey Chase. "An analysis of the impact of the inclusion of expiration data on the fitting of a predictive pulmonary elastance model." Current Directions in Biomedical Engineering 4, no. 1 (2018): 255–58. http://dx.doi.org/10.1515/cdbme-2018-0062.

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AbstractMechanical ventilation is a primary therapy for patients with respiratory failure. However, incorrect ventilator settings can cause lung damage. Optimising ventilation while minimising risk is complex in practice. A common lung protective strategy is to titrate positive end-expiratory pressure (PEEP) to the point of minimum elastance. This process can result in additional available lung volume due to alveolar recruitment but comes with the risk of subjecting the lungs to excessive pressure and lung damage. Predictive elastance models can mitigate this risk by estimating airway pressure

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Triantafillidou, Christina, Effrosyni Manali, Panagiotis Lyberopoulos, et al. "The Role of Cardiopulmonary Exercise Test in IPF Prognosis." Pulmonary Medicine 2013 (2013): 1–9. http://dx.doi.org/10.1155/2013/514817.

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Background. In IPF, defects in lung mechanics and gas exchange manifest with exercise limitation due to dyspnea, the most prominent and disabling symptom.Aim. To evaluate the role of exercise testing through the 6MWT (6-minute walk test) and CPET (cardiopulmonary exercise testing) in the survival of patients with IPF.Methods. This is a prospective, observational study evaluating in 25 patients the relationship between exercise variables through both the 6MWT and CPET and survival.Results. By the end of the observational period 17 patients were alive (33% mortality). Observation ranged from 9 t

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Kulkarni, Apoorva S., and Sheela N. "Methods to Evaluate Airway Resistance and Lung Compliance During Mechanical Ventilation: A Comparative Study." International Journal of Innovative Science and Research Technology 5, no. 7 (2020): 947–51. http://dx.doi.org/10.38124/ijisrt20jul666.

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Mechanical ventilation is a lifesaving activity that is used in critical care management. In such case, monitoring of airway resistance(Raw) and lung compliance(CL) play a major role for diagnosing the lung condition, setting the ventilator parameters, can act as a decision parameter for weaning the patient from the ventilator. Several methods have been described for estimating these respiratory parameters. In this work, a study is conducted to compare two different methods used to calculate airway resistance and lung compliance during mechanical ventilation. Michigan Adult/Infant lung simulat

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Bhatawadekar, Swati A., Del Leary, and Geoffrey N. Maksym. "Modelling resistance and reactance with heterogeneous airway narrowing in mild to severe asthma." Canadian Journal of Physiology and Pharmacology 93, no. 3 (2015): 207–14. http://dx.doi.org/10.1139/cjpp-2014-0436.

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Ventilation heterogeneity is an important marker of small airway dysfunction in asthma. The frequency dependence of respiratory system resistance (Rrs) from oscillometry is used as a measure of this heterogeneity. However, this has not been quantitatively assessed or compared with other outcomes from oscillometry, including respiratory system reactance (Xrs) and the associated elastance (Ers). Here, we used a multibranch model of the human lung, including an upper airway shunt, to match previously reported respiratory mechanics in mild to severe asthma. We imposed heterogeneity by narrowing a

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Zhu, Fang, Charles D. Gomersall, Siu Keung Ng, Malcolm J. Underwood, and Anna Lee. "A Randomized Controlled Trial of Adaptive Support Ventilation Mode to Wean Patients after Fast-track Cardiac Valvular Surgery." Anesthesiology 122, no. 4 (2015): 832–40. http://dx.doi.org/10.1097/aln.0000000000000589.

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Abstract Background: Adaptive support ventilation can speed weaning after coronary artery surgery compared with protocolized weaning using other modes. There are no data to support this mode of weaning after cardiac valvular surgery. Furthermore, control group weaning times have been long, suggesting that the results may reflect control group protocols that delay weaning rather than a real advantage of adaptive support ventilation. Methods: Randomized (computer-generated sequence and sealed opaque envelopes), parallel-arm, unblinded trial of adaptive support ventilation versus physician-direct

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Sigmundsson, Thorir Svavar, Tomas Öhman, Magnus Hallbäck, et al. "Performance of a capnodynamic method estimating cardiac output during respiratory failure - before and after lung recruitment." Journal of Clinical Monitoring and Computing 34, no. 6 (2019): 1199–207. http://dx.doi.org/10.1007/s10877-019-00421-w.

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AbstractRespiratory failure may cause hemodynamic instability with strain on the right ventricle. The capnodynamic method continuously calculates cardiac output (CO) based on effective pulmonary blood flow (COEPBF) and could provide CO monitoring complementary to mechanical ventilation during surgery and intensive care. The aim of the current study was to evaluate the ability of a revised capnodynamic method, based on short expiratory holds (COEPBFexp), to estimate CO during acute respiratory failure (LI) with high shunt fractions before and after compliance-based lung recruitment. Ten pigs we

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Chen, Yuqing, Yueyang Yuan, Hai Zhang, Feng Li, and Xin Zhou. "Accuracy of the dynamic signal analysis approach in respiratory mechanics during noninvasive pressure support ventilation: a bench study." Journal of International Medical Research 49, no. 2 (2021): 030006052199218. http://dx.doi.org/10.1177/0300060521992184.

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Objective To evaluate the accuracy of respiratory mechanics using dynamic signal analysis during noninvasive pressure support ventilation (PSV). Methods A Respironics V60 ventilator was connected to an active lung simulator to model normal, restrictive, obstructive, and mixed obstructive and restrictive profiles. The PSV was adjusted to maintain tidal volumes (VT) that achieved 5.0, 7.0, and 10.0 mL/kg body weight, and the positive end-expiration pressure (PEEP) was set to 5 cmH2O. Ventilator performance was evaluated by measuring the flow, airway pressure, and volume. The system compliance (C

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Xi, Jinxiang, Brendan Walfield, Xiuhua April Si, and Alexander A. Bankier. "Lung Physiological Variations in COVID-19 Patients and Inhalation Therapy Development for Remodeled Lungs." SciMedicine Journal 3, no. 3 (2021): 198–208. http://dx.doi.org/10.28991/scimedj-2021-0303-1.

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In response to the unmet need for effective treatments for symptomatic patients, research efforts of inhaled therapy for COVID-19 patients have been pursued since the pandemic began. However, inhalation drug delivery to the lungs is sensitive to the lung anatomy and physiology, which can be significantly altered due to the viral infection. The ensued ventilation heterogeneity will change distribution and thus dosimetry of inhaled medications, rendering previous correlations concepts? of pulmonary drug delivery in healthy lungs less reliable. In this study, we first reviewed the recent developm

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Su, Marissa, and ehab daoud. "Effect of respiratory effort on target minute ventilation during Adaptive Support Ventilation." Journal of Mechanical Ventilation 2, no. 2 (2021): 53–58. http://dx.doi.org/10.53097/jmv.10022.

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Background: Adaptive support ventilation (ASV) is an intelligent mode of mechanical ventilation protocol which uses a closed-loop control between breaths. The algorithm states that for a given level of alveolar ventilation, there is a particular respiratory rate and tidal volume which achieve a lower work of breathing. The mode allows the clinician to set a desired minute ventilation percentage (MV%) while the ventilator automatically selects the target ventilatory pattern base on these inputs and feedback from the ventilator monitoring system. The goal is to minimize the work of breathing and

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Simon, B. A., and J. G. Venegas. "Analyzing 13NN lung washout curves in the presence of intraregional nonuniformities." Journal of Applied Physiology 76, no. 2 (1994): 956–64. http://dx.doi.org/10.1152/jappl.1994.76.2.956.

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The use of 13NN and positron imaging provides a powerful noninvasive means of assessing regional pulmonary function. Current techniques for analyzing lung washout curves, however, are subject to error due to intraregional nonuniformities, particularly in the presence of areas with very long time constants or gas trapping. This paper presents a simple “hybrid” method for analyzing 13NN-washout studies that addresses the problems of regions of air trapping and long time constants within a region of interest. This method assumes an exponential washout form for the slow regions, estimates their fr

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Audi, Said H., Anthony Cammarata, Anne V. Clough, Ranjan K. Dash, and Elizabeth R. Jacobs. "Quantification of mitochondrial membrane potential in the isolated rat lung using rhodamine 6G." Journal of Applied Physiology 128, no. 4 (2020): 892–906. http://dx.doi.org/10.1152/japplphysiol.00789.2019.

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Mitochondrial membrane potential (Δψm) plays a key role in vital mitochondrial functions, and its dissipation is a hallmark of mitochondrial dysfunction. The objective of this study was to develop an experimental and computational approach for estimating Δψm in intact rat lungs using the lipophilic fluorescent cationic dye rhodamine 6G (R6G). Rat lungs were excised and connected to a ventilation-perfusion system. The experimental protocol consisted of three single-pass phases, loading, washing, and uncoupling, in which the lungs were perfused with R6G-containing perfusate, fresh R6G-free perfu

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