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Dissertations / Theses on the topic 'Lung'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Eriksson, Leif. "Lung transplantation clinical and experimental studies /." Lund : Depts. of Cardiothoracic Surgery, Respiratory Medicine and Clinical Physiology, University of Lund, 1998. http://catalog.hathitrust.org/api/volumes/oclc/39068785.html.

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2

Johansson, Soller Maria. "Cytogenetic studies of lung tumors." Lund : Dept. of Clinical Genetics, University of Lund, 1994. http://catalog.hathitrust.org/api/volumes/oclc/39068855.html.

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3

Wilson, Wendy Lee. "Xanthine oxidase in the lung." Thesis, University of British Columbia, 1987. http://hdl.handle.net/2429/26669.

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The generation of oxygen free radicals by the cytosolic enzyme, xanthine oxidase (XO), has been implicated in post-ischemic or reperfusion damage in several organs. XO catalyzes the conversion of hypoxanthine to urate with the concomitant production of superoxide anion free radical (0₂̅˙) and hydrogen peroxide (H₂O₂). Oxygen free radical-mediated injury has also been demonstrated in inflammatory lung disease. The possible involvement of XO in oxidative injury in the lung has not yet been studied. Therefore, this research project was designed to determine whether XO is present in the lung and

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4

Bastin, Anthony John. "Modulation of lung injury after lung resection." Thesis, Imperial College London, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.536026.

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5

Wolf, Samuel J., Alexander P. Reske, Sören Hammermüller, et al. "Correlation of lung collapse and gas exchange." Universitätsbibliothek Leipzig, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-176099.

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Background: Atelectasis can provoke pulmonary and non-pulmonary complications after general anaesthesia. Unfortunately, there is no instrument to estimate atelectasis and prompt changes of mechanical ventilation during general anaesthesia. Although arterial partial pressure of oxygen (PaO2) and intrapulmonary shunt have both been suggested to correlate with atelectasis, studies yielded inconsistent results. Therefore, we investigated these correlations. Methods: Shunt, PaO2 and atelectasis were measured in 11 sheep and 23 pigs with otherwise normal lungs. In pigs, contrasting measurements were

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6

Johnsson, Hans. "Lung hyaluronan and lung water in the perinatal period." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2001. http://publications.uu.se/theses/91-554-4989-1/.

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7

Cherukupalli, Kamala. "Studies on the normal and abnormal lung growth in the human and in the rat with emphasis on the connective tissue fibers of the lung." Thesis, University of British Columbia, 1989. http://hdl.handle.net/2429/30607.

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Infants with bronchopulmonary dysplasia (BPD), showed impaired body growth when compared to control infants. In terms of changes in the biochemical composition of the lung, BPD infants had higher DNA, soluble protein, collagen and desmosine contents as well as increased concentrations of DNA, collagen and desmosine in their lungs when compared to the growth patterns obtained for the lungs of control infants. Pathologically BPD was classified into 4 grades. Grade I BPD, was a phase of acute lung injury, grades II and III were proliferative phases. In grade IV BPD, lung structure returned toward

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8

Trávníčková, Hana. "Implementace přenosového protokolu pro přenos dat mobilní cirkulační jednotky pro převoz plic." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2014. http://www.nusl.cz/ntk/nusl-220838.

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The aim of this thesis is a data transfer protocol implementation for a mobile control unit for transporting lungs. Apart from this thesis the data transfer protocol is used in AlveoPic project. The introductory part is focused on an anatomical and physiological background of a human respiratory system. Consequently it describes the i-Lung module and the mobile circulation module (MCM). It deals with the healthcare informatics interoperability standards with an emphasis to the ISO/IEEE 11073 standard. The subsequent part is represented by MCM’s simulator realization and design of a monitoring

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9

Irving, Samantha. "Gas mixing in the lungs of children with obstructive lung disease." Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/25402.

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Introduction: CF (cystic fibrosis) and PCD (primary ciliary dyskinesia) are obstructive airway diseases characterised by frequent infections and neutrophilic inflammation. However, PCD has a much milder course than CF. Pilot data showed that in PCD (n=8) the relationship between LCI (lung clearance index) derived from multiple breath washout (MBW), and FEV1 (forced expiratory volume in 1 second) differed from the established correlation in CF. This thesis sought to identify the reasons. Materials and Methods: Larger PCD (n=38) and CF cohorts (n=125), a non-CF bronchiectasis comparator group (n

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10

Grewal, Amardeep Singh. "Prevalence and Outcome of Lung Cancer in Lung Transplant Recipients." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:17295910.

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Lung transplant is the only available therapy for patients with advanced lung disease. The goal of this study was to examine the prevalence, origin, management and outcome of lung cancer in recipients of lung transplant at the Brigham and Women’s Hospital. We conducted a retrospective chart review of all lung transplantations in our institution from January 1990 until June 2012. The prevalence of lung cancer in the explanted lung was 6 (1.2%) of 462 and all cases were in subjects with lung fibrosis. All 4 subjects with lymph node involvement died of causes related to the malignancy. Nine (1.9

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11

Prime, David. "The hydraulic lung." Thesis, Cranfield University, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.420674.

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12

Adams, Angelique Fiona Pelicano. "The Smoking Lung." Thesis, The University of Arizona, 2015. http://hdl.handle.net/10150/579414.

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The goal of this honors thesis is to facilitate in the general public, an understanding of respiratory physiology and the effects of cigarette smoke on respiratory system function. To accomplish this task I created an art installation comprising acrylic paintings on canvas and physiologic forms modelled in clay. After researching the current literature on tobacco smoke and respiratory system function I created these nine art pieces over the course of 16 weeks culminating in a two week (May 4th – May 18th 2015) public health art exhibit in the Kachina Lounge, Student Union, at The Univers

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13

Glendinning, Laura. "Sheep lung microbiota." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/29541.

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Until recently it was assumed that the healthy mammalian lung did not harbour a microbiota, unlike other body sites. However, through the use of sequencing based technologies this has been shown to not be the case. Low biomass communities of microbes can be identified in the healthy lung and the lung microbiota in various diseases states has been shown to differ form these 'healthy' communities. The sheep respiratory microbiota is of interest from both an animal health perspective and due to the potential use of the sheep as a large animal model for studying the lung microbiota. In this thesis

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14

Kamenz, Carsten. "Book-lung morphology." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2010. http://dx.doi.org/10.18452/16070.

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Die Morphologie der Buchlungen von Arachniden (Arachnida Lamarck, 1801 – Arthropoda, Chelicerata) wurde in der vorliegenden Dissertation einer streng vergleichenden Analyse unterzogen, welche mit Hilfe moderner Methoden eine neue Sicht auf die Phylogenie der Arachniden eröffnet. Aus dem Vergleich mit den potentiellen Schwestergruppen (Xiphosura, Eurypterida) und mit Skorpionsfossilien erweist sich der einmalige Landgang eines gemeinsamen Vorfahrens aller rezent terrestrischen Arachniden. Buchlungen-Daten von 200 rezenten + 2 fossilen Skorpionen, 16 Geißelspinnen (Amblypygi), 17 Geißelskorpione

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15

Lehtonen, S. (Siri). "Localization and regulation of peroxiredoxins in human lung and lung diseases." Doctoral thesis, University of Oulu, 2005. http://urn.fi/urn:isbn:9514277651.

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Abstract Reactive oxygen species (ROS) can cause severe damage to cells and organs but they are also important mediators of inflammatory responses and cellular signalling. Due to the significant role of ROS, the cells have evolved a broad antioxidative system to regulate the concentration of these species. Peroxiredoxins (Prxs) are enzymes that participate in the regulation of the cellular redox-homeostasis by detoxifying hydrogen peroxide. Prxs are not classified as conventional antioxidant enzymes and their physiological role, whether protective or regulatory, is still unclear. The aim of

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16

Lee, Richard. "An improved system for lung cancer diagnosis using lung cell images." Diss., Online access via UMI:, 2006.

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17

Min, Yugang. "4D-CT Lung Registration and its Application for Lung Radiation Therapy." Doctoral diss., University of Central Florida, 2012. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/5340.

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Radiation therapy has been successful in treating lung cancer patients, but its efficacy is limited by the inability to account for the respiratory motion during treatment planning and radiation dose delivery. Physics-based lung deformation models facilitate the motion computation of both tumor and local lung tissue during radiation therapy. In this dissertation, a novel method is discussed to accurately register 3D lungs across the respiratory phases from 4D-CT datasets, which facilitates the estimation of the volumetric lung deformation models. This method uses multi-level and multi-resoluti

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18

Heeley, Emma Louise. "Lung surfactant and secretory phospholipase Aâ†2 in inflammatory lung disorders." Thesis, University of Southampton, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.323970.

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19

Räsänen, Noora. "Venous Thromboembolism after Thoracotomy and Lung LobectomyIn Patients with Lung Malignancy." Thesis, Örebro universitet, Institutionen för medicinska vetenskaper, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-73520.

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Background: Venous thromboembolism, manifesting as deep vein thrombosis (DVT) and pulmonary embolism (PE), is a significant source of morbidity and mortality and a cause of postoperative complications after invasive surgery. These adverse events are more likely to occur in high risk patients, such as those with cancer or undergoing major surgery with the highest incidence peak taking place within the first month after surgery. Despite the issue being globally recognized, a lack of consensus regarding guidelines for prophylaxis post-discharge still exists. Aim: To determine the incidence of ven

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20

Pan, Yue. "Currents- and varifolds-based registration of lung vessels and lung surfaces." Thesis, University of Iowa, 2016. https://ir.uiowa.edu/etd/2257.

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This thesis compares and contrasts currents- and varifolds-based diffeomorphic image registration approaches for registering tree-like structures in the lung and surface of the lung. In these approaches, curve-like structures in the lung—for example, the skeletons of vessels and airways segmentation—and surface of the lung are represented by currents or varifolds in the dual space of a Reproducing Kernel Hilbert Space (RKHS). Currents and varifolds representations are discretized and are parameterized via of a collection of momenta. A momenta corresponds to a line segment via the coordinates o

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21

Bingula, Rea. "Non-small cell lung cancer, immunity and microbiota : laying ground for the gut-lung-lung cancer axis in human subjects." Thesis, Université Clermont Auvergne‎ (2017-2020), 2019. http://www.theses.fr/2019CLFAS009.

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Le cancer du poumon est la principale cause de décès par cancer dans le monde. En dépit de la variété de traitements disponibles, tels que la chirurgie, la chimiothérapie, la radiothérapie et l’immunothérapie, la survie moyenne à 5 ans est de 60 %. L’une des raisons sous-jacente est une très grande variabilité de réponse au traitement, expliquée par les antécédents génétiques du patient et depuis peu par son microbiote. Le terme « microbiote » regroupe les bactéries, les archées, les champignons, les virus et les protistes qui colonisent notre organisme. Des études utilisant des modèles animau

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22

Fisher, Andrew John. "The effect of donor lung injury on outcome after human lung transplantation." Thesis, University of Newcastle Upon Tyne, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.391976.

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23

Nelson, Kevin Joseph. "MICRORNA REGULATION OF VENTILATOR INDUCED LUNG INJURY AND PRESSURE-INDUCED LUNG INFLAMMATION." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1462276463.

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24

De, Souza Nicosha. "Molecular epidemiology of lung cancer in the Liverpool Lung Project (LLP) cohort." Thesis, University of Liverpool, 2014. http://livrepository.liverpool.ac.uk/2006199/.

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The primary aim of the project was to evaluate the epidemiological and genetic susceptibility factors associated with lung cancer, in the Liverpool Lung Project (LLP) population. The associated datasets available for research with the LLP dataset (questionnaire) were: Office of National Statistics (ONS), Health Episode Statistics (HES) data with comorbidity data, single nucleotide polymorphism (SNP) data of 570 cases from Liverpool, 3000 controls from the 1958 Birth Cohort. The epidemiological (HES) data was used to study the effect of Charlson (CCI) and Elixhauser comorbidity index (ECI) on t

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25

Motoyama, Hideki. "Plasmin administration during ex vivo lung perfusion ameliorates lung ischemia-reperfusion injury." Kyoto University, 2015. http://hdl.handle.net/2433/200436.

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26

Kondo, Takeshi. "β2-Adrenoreceptor Agonist Inhalation During Ex Vivo Lung Perfusion Attenuates Lung Injury". Kyoto University, 2016. http://hdl.handle.net/2433/215382.

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27

Kozian, Alf. "Pathophysiological and Histomorphological Effects of One-Lung Ventilation in the Porcine Lung." Doctoral thesis, Uppsala universitet, Klinisk fysiologi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-108850.

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Thoracic surgical procedures require partial or complete airway separation and the opportunity to exclude one lung from ventilation (one-lung ventilation, OLV). OLV is commonly associated with profound pathophysiological changes that may affect the postoperative outcome. It is injurious in terms of increased mechanical stress including alveolar cell stretch and overdistension, shear forces secondary to repeated tidal collapse and reopening of alveolar units and compression of alveolar vessels. Ventilation and perfusion distribution may thus be affected during and after OLV. The present studies

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28

Mattes, Charlott, and Ulrich H. Thome. "Rapid elevation of sodium transport through insulin is mediated by AKT in alveolar cells." Universitätsbibliothek Leipzig, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-142643.

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Alveolar fluid clearance is driven by vectorial Na+ transport and promotes postnatal lung adaptation. The effect of insulin on alveolar epithelial Na+ transport was studied in isolated alveolar cells from 18–19-day gestational age rat fetuses. Equivalent short-circuit currents (ISC) were measured in Ussing chambers and different kinase inhibitors were used to determine the pathway of insulin stimulation. In Western Blot measurements the activation of mediators stimulated by insulin was analyzed. The ISC showed a fast dose-dependent increase by insulin, which could be attributed to an increased

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29

Garrad, E. Philippa. "The effects of temperature change and lung expansion on lung liquid production in in vitro preparations of lungs from fetal guinea pigs (Cavia porcellus)." Thesis, University of British Columbia, 1990. http://hdl.handle.net/2429/28989.

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This study examined the effects of lung expansion and changes in temperature on fluid movement by the lungs in the initial period after birth. In addition, experiments with amiloride support the belief that fluid reabsorption acts via a sodium transport mechanism. Lungs from fetal guinea pigs (56-67 days of gestation) were supported in vitro for three hours, and lung liquid production rates were measured using a dye dilution technique. The average production rate in the first hour of untreated preparations was 1.30 ±0.22 ml/kg body weight per hour, and this did not change significantly during

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30

Maksym, Geoffrey Nicholas. "Modelling lung tissue rheology." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ30329.pdf.

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31

Maksym, Geoffrey N. "Modelling lung tissue theology." Thesis, McGill University, 1997. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=42087.

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A model was developed to account for the static elastic behaviour of the lung tissue strip in terms of distributions of collagen and elastin fibers. Distributions of collagen fiber lengths and elastin fiber stiffnesses were determined by fitting the model to data from dog lung tissue strips. These distributions followed 1/f power-laws for more than 95% of the data. Computer simulations of two dimensional tissue strip models with 1/f distributions of collagen fiber lengths also predicted realistic stress-strain curves. The simulations illustrated the gradual development of geometric and stress

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32

Gaskin, Janet. "Radon and Lung Cancer." Thesis, Université d'Ottawa / University of Ottawa, 2019. http://hdl.handle.net/10393/39003.

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Background: Lung cancer was the fifth leading cause of mortality globally in 2010, and the leading cause of cancer mortality in Canada, representing 26% of all cancer deaths for both men and women in 2017. Radon is a very modifiable environmental exposure that is the second most important cause of lung cancer. Objectives: The objectives of this thesis are to quantify the lung cancer burden associated with residential radon and to identify the most cost effective mitigation options to reduce residential radon in Canada. Methods: The global burden of lung cancer mortality attributable to radon

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33

Thomas, Akesh, zainab Fatima, and Girendra resident Hoskere. "Lung Cancer in Tennessee." Digital Commons @ East Tennessee State University, 2021. https://dc.etsu.edu/asrf/2021/presentations/69.

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Introduction Lung cancer is the most common cause of cancer-related death in the United States (US). Tobacco smoking is a well-recognized cause of lung cancer. About 2% of the United States (US) population lives in Tennessee (TN). Nearly 21 % of TN adults are current smokers as per 2019 data, compared to 14% across the US. The percentage of smokers has historically been high in TN and its surroundings. This can be attributed to the area's socio-economic and cultural characteristics, along with large areas of tobacco farming in the region. This increases the risk of lung cancer in the TN popula

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34

Ruiz, Rossana, Marco Galvez-Nino, Ebert Poquioma, et al. "Lung Cancer in Peru." Elsevier Inc, 2020. http://hdl.handle.net/10757/652438.

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Peru is a South American nation with a growing and aging population of 31 million people with a life expectancy at birth of 76.7 years. The country is divided into 25 regions, 79% of the population is urban, and Lima, the capital, concentrates more than a third of the population.1 Although Peru is an upper-middle-income country, health expenditure represents only 5.1% of the gross domestic product, which is lower than the average of Latin America and the Caribbean (LATAM) (8.56%).2 Out-of-pocket health expenditure is 30.9%.3 Peru has a comprehensive National Cancer Plan and two population-base

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35

Katre, Ashwini A. "Ozone and lung fibrosis." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2009. https://www.mhsl.uab.edu/dt/2009m/katre.pdf.

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36

Levin, Andrew Ian. "A study of right ventricular function during one lung anesthesia." Thesis, Stellenbosch : University of Stellenbosch, 2004. http://hdl.handle.net/10019.1/16060.

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Dissertation (PhD)--University of Stellenbosch, 2003.<br>ENGLISH ABSTRACT: Background to the study OLA can give rise to certain problems: 1. A significant decrease in lung volume is reported to occur in the dependent lung during OLA in the LDP. This decrease in lung volume can result in an acute increase in opposition to RV ejection. The potential problem is that the right ventricle is a thin walled structure that can generate considerably less work than the thicker walled LV. It possesses little reserve to deal with an acute rise in afterload as may occur during acute lung injury or aft

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37

Brena, Romulo Martin. "Aberrant DNA methylation in human non-small cell lung cancer." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1172083621.

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38

Lakari, E. (Essi). "Expression of oxidant and antioxidant enzymes in human lung and interstitial lung diseases." Doctoral thesis, University of Oulu, 2002. http://urn.fi/urn:isbn:9514266625.

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Abstract Antioxidants function as blockers of radical processes and eliminate harmful reactive oxygen species (ROS) produced during normal cellular metabolism. A complex antioxidant defence system has evolved to protect the cellular homeostasis. This system includes antioxidant enzymes (AOEs), such as superoxide dismutases (SODs), which are intracellular MnSOD and CuZnSOD and extracellular ECSOD, H2O2 scavenging enzymes catalase and glutathione peroxidase, and hemeoxygenase-1 (HO-1), an important enzyme in heme metabolism, which has also been suggested to have antioxidant capacities. ROS play

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39

Lu, Yen-Ta. "Mechanisms of ischemia-reperfusion lung injury in the isolated, blood-perfused rat lung." Thesis, Imperial College London, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.265706.

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40

Birch, Jodie. "Telomere dysfunction and senescence in the ageing lung and age-related lung disease." Thesis, University of Newcastle upon Tyne, 2015. http://hdl.handle.net/10443/3927.

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Cellular senescence, the irreversible loss of replicati ve capacity of somatic cells, bas been associated w ith diseases of accelerated lung ageing, including Chroni c Obstructive Pulmonaty Disease (COPD). However, the mechanisms und erl ying senescence of a irway epithelial cell s, parti cula rl y the role of telomere dysfunction in this process, are poorly understood . The aim of this work was to investigate senescence and telomere dysfunction in airway epithelial cells from pati ents with COPD and bronchiectasis, in the ageing murine lung and in the context of cigarette smoke exposure. DNA

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Salvati, Valentina. "Development of effective lung cancer therapies based on lung cancer stem cella targeting." Doctoral thesis, Università di Catania, 2015. http://hdl.handle.net/10761/4035.

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Il carcinoma polmonare non a piccole cellule (NSCLC) rappresenta circa l 80% di tutti i tumori al polmone ed è il cancro più comune e più mortale al mondo. Il trattamento convenzionale per il NSCLC in stadio avanzato è stato basato per molto tempo sull uso della chemioterapia, ma con basso impatto sulla sopravvivenza . Una migliore comprensione dei meccanismi molecolari coinvolti nel processo di tumorigenesi e una maggiore capacità nell identificazione di specifiche alterazioni genetiche come bersagli terapeutici, hanno portato ad un significativo avanzamento verso lo sviluppo di terapie più

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Terlizzi, Michela. "Role of the inflammasome in lung cancer Inflammasome is involved in lung carcinogenesis." Doctoral thesis, Universita degli studi di Salerno, 2017. http://hdl.handle.net/10556/2410.

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2014 - 2015<br>Lung cancer is recognized as one of the most devastating tumor worldwide due to the low rate survival over 5 years from the time of diagnosis. Inflammation has been widely recognized as the seventh hallmark of cancer as it facilitates the establishment/development and progression of lung cancer. In this context, recent evidence highlighted the role of the inflammasome during carcinogenesis. However, little is still known. The inflammasome is a multiprotein complex that leads to caspase-1 activation which role in lung cancer is still under investigated. In this context, the aim o

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43

Woods, Birgitta A. "The effects of epinephrine, AVP, norepinephrine, and acetylcholine on lung liquid production in in vitro preparations of lungs from fetal guinea pigs (Cavia porcellus)." Thesis, University of British Columbia, 1991. http://hdl.handle.net/2429/29821.

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This study examined the effects of epinephrine, norepinephrine, AVP and ACh on fluid movement by the lungs of the late-term guinea pig fetus. Catecholamines and AVP are secreted in high amounts by the fetus during delivery, and could be important with respect to fetal lung fluid removal; this event is vital at the time of birth. The lungs were supported in vitro for a duration of three hours, and production rates were measured using a dye-dilution technique. The average resting production rate in terms of ml/kg‧h declined with gestational age (54-67 days gestation; n=171). There was a lesser

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44

Chen, Patty P. 1981. "Lung tissue engineering : in vitro synthesis of lung tissue from neonatal and fetal rat lung cells cultured in a three-dimensional collagen matrix." Thesis, Massachusetts Institute of Technology, 2004. http://hdl.handle.net/1721.1/28758.

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Thesis (M. Eng.)--Harvard-MIT Division of Health Sciences and Technology, 2004.<br>Includes bibliographical references (p. 76-77).<br>The focus of this study was to investigate the histology of tissue formed when fetal (16-20 days gestation) and neonatal (2 days old) rat lung cells were grown in a collagen-glycosaminoglycan scaffold. This project employed a collagen-GAG scaffold specifically developed for tissue engineering and investigated the effect of this substratum on the formation of lung histotypic structures in vitro. A cell isolation procedure was developed whereby 19-days gestation t

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45

Fuest, Sven [Verfasser]. "Protective signalling mechanisms in the lung induced by open-lung ventilation strategies / Sven Fuest." Gießen : Universitätsbibliothek, 2014. http://d-nb.info/106847453X/34.

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46

Jackson, Erica L. (Erica Lynn) 1973. "Mouse models of lung cancer : understanding the molecular and cellular basis of lung tumorigenesis." Thesis, Massachusetts Institute of Technology, 2003. http://hdl.handle.net/1721.1/29992.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2003.<br>Includes bibliographical references.<br>Lung cancer is the leading cause of cancer deaths worldwide. Patients are typically diagnosed with advanced disease and have a high fatality:case ratio. Despite its prevalence, the identity of the cell of origin, precursor lesions and stages of disease progression have not been well characterized for most types of lung cancer. Furthermore, there are no effective screening methods for lung cancer and standard chemotherapeutics are ineffective in treating advanced lung cance

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Wakabayashi, Kenji. "Investigation of the mechanisms of acute lung injury, using an isolated perfused mouse lung." Thesis, Imperial College London, 2012. http://hdl.handle.net/10044/1/10143.

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Acute lung injury (ALI) is a severe inflammatory lung disease with high mortality. Previous studies revealed several important concepts in ALI, including cellular interaction between lung-marginated leukocytes and pulmonary endothelium, and decompartmentalisation of soluble mediators. However, there are inherent limitations within both in vivo and in vitro models to identify the detailed mechanism underlying these concepts. In this PhD project, we attempted to address these unanswered questions, using an in situ isolated perfused mouse lung (IPL). Specifically, we aimed to 1) develop, characte

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Şeşen, Mustafa Berkan. "Lung cancer assistant : a hybrid clinical decision support application in lung cancer treatment selection." Thesis, University of Oxford, 2013. https://ora.ox.ac.uk/objects/uuid:e0dd01e4-3f18-49ed-89af-5e81894d4967.

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We describe an online clinical decision support (CDS) system, Lung Cancer Assistant (LCA), which we have developed to aid the clinicians in arriving at informed treatment decisions for lung cancer patients at multidisciplinary team (MDT) meetings. LCA integrates rule-based and probabilistic decision support within a single platform. To our knowledge, this is the first time this has been achieved in the context of CDS in cancer care. Rule-based decision support is achieved by an original ontological guideline rule inference framework that operates on a domain-specific module of Systematized Nom

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Nishikawa, Shigeto. "Statins may have double-edged effects in patients with lung adenocarcinoma after lung resection." Kyoto University, 2019. http://hdl.handle.net/2433/243305.

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Stabler, Collin Turner. "Optimizing Endothelial Repopulation of Decellularized Lung." Diss., Temple University Libraries, 2016. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/388434.

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Bioengineering<br>Ph.D.<br>Decellularized lung tissue has been recognized as a potential platform to engineer whole lung organs suitable for transplantation or for modeling a variety of lung diseases. However many technical hurdles remain before this potential may be fully realized. Inability to efficiently re-endothelialize the pulmonary vasculature with a functional endothelium appears to be the primary cause of failure of recellularized lung scaffolds in early transplant studies. This dissertation research aims to enhance the re-endothelialization of decellularized rodent lung scaffolds wit

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