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Journal articles on the topic 'Lung'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Harding, R., and S. B. Hooper. "Regulation of lung expansion and lung growth before birth." Journal of Applied Physiology 81, no. 1 (1996): 209–24. http://dx.doi.org/10.1152/jappl.1996.81.1.209.

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Fetal lung growth depends on the degree to which lungs are distended with luminal liquid. Fetal lungs are highly distended such that mean luminal volume exceeds the static relaxation volume. This high level of expansion is maintained by fetal breathing movements and by resistive effects of the upper airway during apnea; both factors oppose lung recoil. Mechanical stress in lung and other tissues stimulates cell division and tissue remodeling. Potential transduction mechanisms involve direct effects of cellular tension and mediation of locally released mitogenic factors. Further studies are req

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2

Fabrika, A. P., E. P. Tychina, A. M. Bayramkulov, and E. A. Tarabrin. "Ex vivo lung perfusion in lung transplantation." Transplantologiya. The Russian Journal of Transplantation 16, no. 1 (2024): 99–115. http://dx.doi.org/10.23873/2074-0506-2024-16-1-99-115.

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Introduction. The number of lung transplants performed worldwide is not enough because of a shortage of suitable (ideal) donors, missed chances to use lungs from donors who died of cardiac arrest, the lack of resources to perform this technically complex operation in poor, developing countries and due to a number of other reasons.) The world literature sources contain information about an increase in the number of lung transplantations by using organs from non-ideal (suboptimal and marginal) donors. This became possible thanks to the technology of ex vivo normothermic perfusion of donor lungs.

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Kirillova, E., N. Shamsutdinova, and G. Nurullina. "THU0534 LUNG ULTRASOUND IN PATIENTS WITH SECONDARY INTERSTITIAL LUNG DISEASES." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 506.2–507. http://dx.doi.org/10.1136/annrheumdis-2020-eular.5168.

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Background:Currently, lung ultrasound (LUS) is increasingly used in rheumatology.Objectives:To evaluate the relationship between lung ultrasound and pulmonary function and disease activity in patients with rheumatic diseases with secondary lung involvement.Methods:Thirty patients with rheumatic diseases were included in the study, who, according to the data of the high-resolution RCT of lungs (64-slice CT system Philips Diamond Select Brilliance), showed interstitial lung involvement as a type of nonspecific interstitial pneumonia. In 4 patients, mixed connective tissue disease (MCTD) was diag

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Koch, Achim, Nikolaus Pizanis, Carolin Olbertz, et al. "One-year experience with ex vivo lung perfusion: Preliminary results from a single center." International Journal of Artificial Organs 41, no. 8 (2018): 460–66. http://dx.doi.org/10.1177/0391398818783391.

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Objective: To enlarge the donor pool for lung transplantation, an increasing number of extended criteria donor lungs are used. However, in more than 50% of multi-organ donors the lungs are not used. Ex vivo lung perfusion offers a unique possibility to evaluate and eventually recondition the injured donor lungs. The aim of our study was to assess the enlargement of the donor pool and the outcome with extended criteria donor lungs after ex vivo lung perfusion. Patients and Methods: Data were prospectively collected in our lung transplant database. We compared the results of lung transplants aft

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Chen, Jiawen, Ting Li, Chun Ye, et al. "The Lung Microbiome: A New Frontier for Lung and Brain Disease." International Journal of Molecular Sciences 24, no. 3 (2023): 2170. http://dx.doi.org/10.3390/ijms24032170.

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Due to the limitations of culture techniques, the lung in a healthy state is traditionally considered to be a sterile organ. With the development of non-culture-dependent techniques, the presence of low-biomass microbiomes in the lungs has been identified. The species of the lung microbiome are similar to those of the oral microbiome, suggesting that the microbiome is derived passively within the lungs from the oral cavity via micro-aspiration. Elimination, immigration, and relative growth within its communities all contribute to the composition of the lung microbiome. The lung microbiome is r

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Margulies, S. S., R. W. Schriner, M. A. Schroeder, and R. D. Hubmayr. "Static lung-lung interactions in unilateral emphysema." Journal of Applied Physiology 73, no. 2 (1992): 545–51. http://dx.doi.org/10.1152/jappl.1992.73.2.545.

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Motivated by the introduction of single-lung transplantation into clinical practice, we compared the static mechanical properties of the respiratory system in six supine dogs before (at baseline) with those after the induction of unilateral emphysema. Relaxation volume (Vrel), total lung capacity (TLC), and static compliance of the emphysematous lung increased to 214 +/- 68, 186 +/- 39, and 253 +/- 95% (SD) of baseline, respectively. Vrel of the nonemphysematous lung fell to 81 +/- 28% of baseline, with no significant change in TLC of the nonemphysematous lung or its pressure-volume relationsh

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Wesnawa, Made Agustya Darma Putra, I. Made Subagiarta, and Evelyn Nathania. "Lung Aging and Lung Function Assessment in Elderly." Jurnal Respirasi 11, no. 1 (2025): 93–100. https://doi.org/10.20473/jr.v11-i.1.2025.93-100.

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The lung is one of the organs that experiences the most frequent decline in function among the elderly. Reduced lung function associated with aging is a physiological condition. The lungs transform both their cellular composition and their functional capabilities. The lungs of an aging population may show structural changes to the respiratory muscles, chest wall, lung parenchyma, and upper and lower respiratory tracts. The elderly are more susceptible to reduced lung perfusion, respiratory mechanics, infection, and weaker respiratory muscles because of aging. The body plethysmograph, oscillome

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8

Syed, Ahad, Sarah Kerdi, and Adnan Qamar. "Bioengineering Progress in Lung Assist Devices." Bioengineering 8, no. 7 (2021): 89. http://dx.doi.org/10.3390/bioengineering8070089.

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Artificial lung technology is advancing at a startling rate raising hopes that it would better serve the needs of those requiring respiratory support. Whether to assist the healing of an injured lung, support patients to lung transplantation, or to entirely replace native lung function, safe and effective artificial lungs are sought. After 200 years of bioengineering progress, artificial lungs are closer than ever before to meet this demand which has risen exponentially due to the COVID-19 crisis. In this review, the critical advances in the historical development of artificial lungs are detai

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9

Cutillo, A. G., K. C. Goodrich, K. Ganesan, et al. "Lung water measurement by nuclear magnetic resonance: correlation with morphometry." Journal of Applied Physiology 79, no. 6 (1995): 2163–68. http://dx.doi.org/10.1152/jappl.1995.79.6.2163.

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Estimates of lung water content obtained from nuclear magnetic resonance (NMR) and morphometric and gravimetric measurements were compared in normal and experimentally injured rats. Average lung water density (rho H2O) was measured by an NMR technique in excised unperfused rat lungs (20 normal lungs and 12 lungs with oleic acid-induced edema) at 0 (full passive deflation) and 30 cmH2O lung inflation pressure and in vivo (4 normal rats and 8 rats with lung injury induced by oleic acid or rapid saline infusion). The rho H2O values were compared with morphometric measurements of lung tissue volum

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Horalskyi, L., N. Hlukhova, and I. Sokulskyi. "Morphological traits of rabbit lung." Scientific Horizons 93, no. 8 (2020): 180–88. http://dx.doi.org/10.33249/2663-2144-2020-93-8-180-188.

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In the article, following the results of complex methods (anatomic, histologic, organometric, histometric and statistical) researches are shown the features of morphological structure and morphometric parameters of the lungs of mature rabbits. It was found out, that macro- and microscopic architecture of rabbit lungs has similar histoarchitectonics, inherent in other species of farm animals of the class "mammals" and the characteristic features of morphological structures. Lungs in clinically healthy rabbits structurally reflect the shape of thoracic cavity and gradually expand ventrally. Subs

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11

Estenne, Marc, Henry E. Fessler, and Malcolm M. DeCamp. "Lung Transplantation and Lung Volume Reduction Surgery." Comprehensive Physiology 1, no. 3 (2011): 1383–412. https://doi.org/10.1002/j.2040-4603.2011.tb00364.x.

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AbstractSince the publication of the last edition of the Handbook of Physiology, lung transplantation has become widely available, via specialized centers, for a variety of end‐stage lung diseases. Lung volume reduction surgery, a procedure for emphysema first conceptualized in the 1950s, electrified the pulmonary medicine community when it was rediscovered in the 1990s. In parallel with their technical and clinical refinement, extensive investigation has explored the unique physiology of these procedures. In the case of lung transplantation, relevant issues include the discrepant mechanical f

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12

Srinivasan, Hari B., Stephen M. Vogel, Dharmapuri Vidyasagar, and Asrar B. Malik. "Protective effect of lung inflation in reperfusion-induced lung microvascular injury." American Journal of Physiology-Heart and Circulatory Physiology 278, no. 3 (2000): H951—H957. http://dx.doi.org/10.1152/ajpheart.2000.278.3.h951.

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We used the isolated-perfused rat lung model to study the influence of pulmonary ventilation and surfactant instillation on the development of postreperfusion lung microvascular injury. We hypothesized that the state of lung inflation during ischemia contributes to the development of the injury during reperfusion. Pulmonary microvascular injury was assessed by continuously monitoring the wet lung weight and measuring the vessel wall125I-labeled albumin (125I-albumin) permeability-surface area product ( PS). Sprague-Dawley rats ( n = 24) were divided into one control group and five experimental

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13

Neumann, Peter, Jan Erik Berglund, Enrique Fernández Mondéjar, Anders Magnusson, and Göran Hedenstierna. "Dynamics of lung collapse and recruitment during prolonged breathing in porcine lung injury." Journal of Applied Physiology 85, no. 4 (1998): 1533–43. http://dx.doi.org/10.1152/jappl.1998.85.4.1533.

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Oleic acid (OA) injection, lung lavage, and endotoxin infusion are three commonly used methods to induce experimental lung injury. The dynamics of lung collapse and recruitment in these models have not been studied, although knowledge of this is desirable to establish ventilatory techniques that keep the lungs open. We measured lung density by computed tomography during breath-holding procedures. Lung injury was induced with OA, lung lavage, or endotoxin in groups of six mechanically ventilated pigs. After a stabilization period, repetitive computed tomography scans of the same slice were obta

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14

Rakhmonova, H.N, S.M Mukhitdinova, and F.Z Rakhmonov. "MORPHOLOGICAL STRUCTURE OF NEUROEPITHELIAL CELLS IN RABBIT LUNGS." Journal of Science-Innovative Research in Uzbekistan 2, no. 2 (2024): 153–56. https://doi.org/10.5281/zenodo.10645714.

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The morphofunctional features of NET in the developing respiratory lung have been studied. Lungs of 23 rabbits aged 1-30 days served as a material for the study. Paraffin sections were stained with hematoxylin and eosin, according to the Van-Gizon method, impregnated according to the Grimelius method. Histochemical detection of acetylcholinesterase (AChE) activity was carried out on frozen sections of unfixed lungs by the method of M. Karnovsky and L. Roots. The study allowed to establish that in the rabbit lung NET cells are detected in the respiratory secti

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15

Szpinda, Michał, Waldemar Siedlaczek, Anna Szpinda, Alina Woźniak, Celestyna Mila-Kierzenkowska, and Mateusz Badura. "Quantitative Anatomy of the Growing Lungs in the Human Fetus." BioMed Research International 2015 (2015): 1–10. http://dx.doi.org/10.1155/2015/362781.

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Using anatomical, digital, and statistical methods we examined the three-dimensional growth of the lungs in 67 human fetuses aged 16–25 weeks. The lung dimensions revealed no sex differences. The transverse and sagittal diameters and the base circumference were greater in the right lungs while the lengths of anterior and posterior margins and the lung height were greater in the left lungs. The best-fit curves for all the lung parameters were natural logarithmic models. The transverse-to-sagittal diameter ratio remained stable and averaged0.56±0.08and0.52±0.08for the right and left lungs, respe

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16

Bryan, C. L., A. J. Patefield, D. Cohen, J. L. Nielsen, B. Emanuel, and J. H. Calhoon. "Assessment of injury in transplanted and nontransplanted lungs after 6 h of cold storage with glutathione." Journal of Applied Physiology 76, no. 3 (1994): 1232–41. http://dx.doi.org/10.1152/jappl.1994.76.3.1232.

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Single-lung transplantation after 3 h of hypothermic storage produces bilateral lung injury [pulmonary reimplantation response (PRR)]. We hypothesized that glutathione (GSH) hypothermic storage would protect both lungs from PRR for extended preservation times and that differences in injury and protection would be realized between the graft and the nontransplanted lung. Mongrel dogs underwent left single-lung autotransplantation after preservation for 5–6 h in Euro-Collins (EC) solution, EC plus exogenous GSH (EC+GSH), or Viaspan (VIA) at 4 degrees C. Lung injury was measured in both lungs afte

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17

Jackson, R. M., W. J. Russell, and C. F. Veal. "Endogenous and exogenous catalase in reoxygenation lung injury." Journal of Applied Physiology 72, no. 3 (1992): 858–64. http://dx.doi.org/10.1152/jappl.1992.72.3.858.

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Reexpansion pulmonary edema parallels reperfusion (reoxygenation) injuries in other organs in that hypoxic and hypoperfused lung tissue develops increased vascular permeability and neutrophil infiltration after reexpansion. This study investigated endogenous lung catalase activity and H2O2 production during hypoxia (produced by lung collapse) and after reoxygenation (resulting from reexpansion), in addition to assessing the effects of exogenous catalase infusion on the development of unilateral pulmonary edema after reexpansion. Lung collapse resulted in a progressive increase in endogenous ca

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18

Chen, Fengshi, Toru Bando, Tatsuo Fukuse, et al. "LTC-2 Recurrent Lymphangioleiomyomatosis after Lung Transplantation(Lung Transplant Conference)." Journal of the Japanese Association for Chest Surgery 20, no. 3 (2006): 981. http://dx.doi.org/10.2995/jacsurg.20.981_2.

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19

Khubutiya, M. Sh, A. M. Gasanov, E. A. Tarabrin, T. V. Chernen’kaya, T. E. Kallagov, and E. I. Pervakova. "A comparison of airway microbiota in donors and recipients of lung transplants." Russian Pulmonology 29, no. 2 (2019): 184–88. http://dx.doi.org/10.18093/0869-0189-2019-29-2-184-188.

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This study was aimed at investigation of relationships between bronchial washing culture in post-transplant recipient and bronchial flora of the lung donor. Methods. A comparative analysis of bronchial washing cultures from 30 post-transplant lung recipients was performed. All lung donors were stratified to ideal, suboptimal and marginal donors according to the lung transplant suitability. Results. As a result, development of post-transplant pulmonary complications was directly related to bacterial flora of the donor lung. The incidence of pneumonia in post-transplant patients was 3.3% after t

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20

Joshua, Eali Stephen Neal. "LUNG NODULE SEMANTIC SEGMENTATION WITH BI-DIRECTION FEATURES USING U-INET." Journal of Medical pharmaceutical and allied sciences 10, no. 5 (2021): 3494–99. http://dx.doi.org/10.22270/jmpas.v10i5.1454.

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It's difficult to detect lung cancer and determine the severity of the disease without a CT scan of the lungs. The anonymity of nodules, as well as physical characteristics such as curvature and surrounding tissue, suggest that CT lung nodule segmentation has limitations. According to the study, a new, resource-efficient deep learning architecture dubbed U-INET is required. When a doctor orders a computed tomography (CT) scan for cancer diagnosis, precise and efficient lung nodule segmentation is required. Due to the nodules' hidden form, poor visual quality, and context, lung nodule segmentat

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21

Pérez-Bravo, David, Despoina Myti, Ivana Mižíková, et al. "A comparison of airway pressures for inflation fixation of developing mouse lungs for stereological analyses." Histochemistry and Cell Biology 155, no. 2 (2020): 203–14. http://dx.doi.org/10.1007/s00418-020-01951-0.

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AbstractThe morphometric analysis of lung structure using the principles of stereology has emerged as a powerful tool to describe the structural changes in lung architecture that accompany the development of lung disease that is experimentally modelled in adult mice. These stereological principles are now being applied to the study of the evolution of the lung architecture over the course of prenatal and postnatal lung development in mouse neonates and adolescents. The immature lung is structurally and functionally distinct from the adult lung, and has a smaller volume than does the adult lung

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Stella, Giulia M., Stefan Kolling, Silvia Benvenuti, and Chandra Bortolotto. "Lung-Seeking Metastases." Cancers 11, no. 7 (2019): 1010. http://dx.doi.org/10.3390/cancers11071010.

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Metastases from different cancer types most often affect the lung parenchyma. Moreover, the lungs are among the most frequent sites of growth of metastatic masses of uncertain/unknown lineage of origin. Thus, with regards to pulmonary neoplastic parenchymal nodules, the critical issue is to determine if they are IN the lung or OF the lung. In this review, we highlight the clinical, instrumental and molecular features which characterize lung metastases, mainly focusing on recently advancing and emerging concepts regarding the metastatic niche, inflammation, angiogenesis, immune modulation and g

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23

Abernathy, V. J., N. A. Pou, R. E. Parker, and R. J. Roselli. "Evaluation of perilla ketone-induced unilateral lung injury using external gamma scanning." Journal of Applied Physiology 76, no. 1 (1994): 138–45. http://dx.doi.org/10.1152/jappl.1994.76.1.138.

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We used a modified external gamma scanning technique to quantitate right and left lung permeability changes to iodinated sheep albumin before and after perilla ketone (PK)-mediated unilateral lung injury in seven anesthetized sheep. Three portable gamma scintillation probes containing 2-in. NaI crystals detected radioactivities of 51Cr-labeled red blood cells and 125I-labeled albumin over the right and left lungs and blood, respectively. Radioactivities were monitored for 1 h before and 3 h after infusion of 25 mg/kg PK into a single lung. Calculation of normalized slope index (NSI) (Roselli a

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Chen, C. R., N. F. Voelkel, and S. W. Chang. "PAF potentiates protamine-induced lung edema: role of pulmonary venoconstriction." Journal of Applied Physiology 68, no. 3 (1990): 1059–68. http://dx.doi.org/10.1152/jappl.1990.68.3.1059.

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We studied the synergistic interaction between platelet-activating factor (PAF) and protamine sulfate, a cationic protein that causes pulmonary endothelial injury, in isolated rat lungs perfused with a physiological salt solution. A low dose of protamine (50 micrograms/ml) increased pulmonary artery perfusion pressure (Ppa) but did not increase wet lung-to-body weight ratio after 20 min. Pretreatment of the lungs with a noninjurious dose of PAF (1.6 nM) 10 min before protamine markedly potentiated protamine-induced pulmonary vasoconstriction and resulted in severe lung edema and increased lung

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Milross, Luke, Chelsea Griffiths, and Andrew J. Fisher. "Ex Vivo Lung Perfusion: A Platform for Donor Lung Assessment, Treatment and Recovery." Transplantology 2, no. 4 (2021): 387–95. http://dx.doi.org/10.3390/transplantology2040037.

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Lung transplantation offers a lifesaving therapy for patients with end-stage lung disease but its availability is presently limited by low organ utilization rates with donor lungs frequently excluded due to unsuitability at assessment. When transplantation does occur, recipients are then vulnerable to primary graft dysfunction (PGD), multitudinous short-term complications, and chronic lung allograft dysfunction. The decision whether to use donor lungs is made rapidly and subjectively with limited information and means many lungs that might have been suitable are lost to the transplant pathway.

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Gilpin, Sarah E., and Darcy E. Wagner. "Acellular human lung scaffolds to model lung disease and tissue regeneration." European Respiratory Review 27, no. 148 (2018): 180021. http://dx.doi.org/10.1183/16000617.0021-2018.

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Recent advances in whole lung bioengineering have opened new doors for studying lung repair and regeneration ex vivo using acellular human derived lung tissue scaffolds. Methods to decellularise whole human lungs, lobes or resected segments from normal and diseased human lungs have been developed using both perfusion and immersion based techniques. Immersion based techniques allow laboratories without access to intact lobes the ability to generate acellular human lung scaffolds. Acellular human lung scaffolds can be further processed into small segments, thin slices or extracellular matrix ext

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27

Pronych, Scott, and Richard Wassersug. "Lung use and development in Xenopus laevis tadpoles." Canadian Journal of Zoology 72, no. 4 (1994): 738–43. http://dx.doi.org/10.1139/z94-099.

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Shortly after hatching, Xenopus laevis tadpoles fill their lungs with air. We examined the role played by early lung use in these organisms, since they are able to respire with both their lungs and their gills. We investigated the effect on X. laevis development when the larvae were prevented from inflating their lungs, and whether early lung use influenced the size of the lungs or the tadpole's ability to metamorphose. Tadpoles that were denied access to air had lungs one-half the size of those of controls. This difference in lung size was too large to be explained merely by a stretching of t

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Nelson, Alexander J., and Yee Ling Wu. "Allergen inhalation transforms the lungs into a permissive environment for local IgE responses." Journal of Immunology 210, no. 1_Supplement (2023): 156.05. http://dx.doi.org/10.4049/jimmunol.210.supp.156.05.

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Abstract Immunoglobulin E (IgE) is the primary cause of allergic diseases and must be tightly regulated. Production of IgE occurs when activated B cells undergo class switch recombination (CSR) to IgE. These key events are rare, thus questions on which B cell subsets undergo IgE CSR, where IgE CSR predominantly occurs, and which molecular and cellular signals promote IgE CSR remain unresolved. We modeled allergic asthma by intranasal administration of ragweed pollen and ovalbumin (OVA) in mice, and found that allergen inhalation induced the formation of lymphoid aggregates and production of OV

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Shibuya, Soichi, Jessica Allen-Hyttinen, Paolo De Coppi, and Federica Michielin. "In vitro models of fetal lung development to enhance research into congenital lung diseases." Pediatric Surgery International 37, no. 5 (2021): 561–68. http://dx.doi.org/10.1007/s00383-021-04864-8.

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AbstractPurposeThis paper aims to build upon previous work to definitively establish in vitro models of murine pseudoglandular stage lung development. These can be easily translated to human fetal lung samples to allow the investigation of lung development in physiologic and pathologic conditions.MethodsLungs were harvested from mouse embryos at E12.5 and cultured in three different settings, i.e., whole lung culture, mesenchyme-free epithelium culture, and organoid culture. For the whole lung culture, extracted lungs were embedded in Matrigel and incubated on permeable filters. Separately, di

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Cereda, Maurizio, Yi Xin, Hooman Hamedani, et al. "Mild loss of lung aeration augments stretch in healthy lung regions." Journal of Applied Physiology 120, no. 4 (2016): 444–54. http://dx.doi.org/10.1152/japplphysiol.00734.2015.

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Inspiratory stretch by mechanical ventilation worsens lung injury. However, it is not clear whether and how the ventilator damages lungs in the absence of preexisting injury. We hypothesized that subtle loss of lung aeration during general anesthesia regionally augments ventilation and distension of ventilated air spaces. In eight supine anesthetized and intubated rats, hyperpolarized gas MRI was performed after a recruitment maneuver following 1 h of volume-controlled ventilation with zero positive end-expiratory pressure (ZEEP), FiO20.5, and tidal volume 10 ml/kg, and after a second recruitm

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Sozo, Foula, Megan J. Wallace, Valerie A. Zahra, Caitlin E. Filby, and Stuart B. Hooper. "Gene expression profiling during increased fetal lung expansion identifies genes likely to regulate development of the distal airways." Physiological Genomics 24, no. 2 (2006): 105–13. http://dx.doi.org/10.1152/physiolgenomics.00148.2005.

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Growth and development of the fetal lungs is critically dependent on the degree to which the lungs are expanded by liquid; increases in fetal lung expansion accelerate lung growth, whereas reductions in lung expansion cause lung growth to cease. The mechanisms mediating expansion-induced lung growth are unknown but likely include alterations in the expression of genes that regulate lung cell proliferation. Our aim was to isolate and identify genes that are up- or downregulated by increased fetal lung expansion. In chronically catheterized fetal sheep at 126 days gestational age (GA), the left

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Lawrence, E. Clinton. "Lung transplantation for COPD: one lung, two lungs, or none?" Lancet 371, no. 9614 (2008): 702–3. http://dx.doi.org/10.1016/s0140-6736(08)60319-0.

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Bilali, Aishan, Shunichi Kurata, Satoshi Ikeda, et al. "Lung–lung interaction in isolated perfused unilateral hyperventilated rat lungs." Translational Research 155, no. 5 (2010): 228–37. http://dx.doi.org/10.1016/j.trsl.2010.01.001.

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Wright, Casey M., Rayleen V. Bowman, Maxine E. Tan, et al. "Lung Asbestos Content in Lungs Resected for Primary Lung Cancer." Journal of Thoracic Oncology 3, no. 6 (2008): 569–76. http://dx.doi.org/10.1097/jto.0b013e318174e046.

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Kitterman, Joseph A. "Physiological factors in fetal lung growth." Canadian Journal of Physiology and Pharmacology 66, no. 8 (1988): 1122–28. http://dx.doi.org/10.1139/y88-184.

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Adequate pulmonary function at birth depends upon a mature surfactant system and lungs of normal size. Surfactant is controlled primarily by hormonal factors, especially from the hypophysis, adrenal, and thyroid; but these have little influence on fetal lung growth. In contrast, current data indicate that lung growth is determined by the following physical factors that permit the lungs to express their inherent growth potential. (a) Adequate intrathoracic space: lesions that decrease intrathoracic space impede lung growth, apparently by physical compression. (b) Adequate amount of amniotic flu

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Yu, Yeuni, Yun Hak Kim, Woo Hyun Cho, et al. "Unique Changes in the Lung Microbiome following the Development of Chronic Lung Allograft Dysfunction." Microorganisms 12, no. 2 (2024): 287. http://dx.doi.org/10.3390/microorganisms12020287.

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The importance of lung microbiome changes in developing chronic lung allograft dysfunction (CLAD) after lung transplantation is poorly understood. The lung microbiome–immune interaction may be critical in developing CLAD. In this context, examining alterations in the microbiome and immune cells of the lungs following CLAD, in comparison to the lung condition immediately after transplantation, can offer valuable insights. Four adult patients who underwent lung retransplantation between January 2019 and June 2020 were included in this study. Lung tissues were collected from the same four individ

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Moores, H. K., C. J. Beehler, M. E. Hanley, et al. "Xanthine oxidase promotes neutrophil sequestration but not injury in hyperoxic lungs." Journal of Applied Physiology 76, no. 2 (1994): 941–45. http://dx.doi.org/10.1152/jappl.1994.76.2.941.

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Neutrophil accumulation in alveolar spaces is a conspicuous finding in hyperoxia-exposed lungs. We hypothesized that xanthine oxidase (XO)-derived oxidants contribute to retention of neutrophils in hyperoxic lungs. Rats were subjected to normobaric hyperoxia (100% O2) for 48 h, and lungs were assessed for neutrophil sequestration (morphometry and lavage cell counts) and injury (lavage albumin levels and lung weights). In rats exposed to hyperoxia, we found increased (P < 0.05) lung neutrophil retention, lavage albumin levels, and lung weights compared with normoxia-exposed control rats. Sup

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Ramanathan, Kollengode, Hend Mohammed, Peter Hopkins, et al. "Single-Lung Transplant Results in Position Dependent Changes in Regional Ventilation: An Observational Case Series Using Electrical Impedance Tomography." Canadian Respiratory Journal 2016 (2016): 1–6. http://dx.doi.org/10.1155/2016/2471207.

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Background. Lung transplantation is the optimal treatment for end stage lung disease. Donor shortage necessitates single-lung transplants (SLT), yet minimal data exists regarding regional ventilation in diseased versus transplanted lung measured by Electrical Impedance Tomography (EIT).Method. We aimed to determine regional ventilation in six SLT outpatients using EIT. We assessed end expiratory volume and tidal volumes. End expiratory lung impedance (EELI) and Global Tidal Variation of Impedance were assessed in supine, right lateral, left lateral, sitting, and standing positions in transplan

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Sakuma, Tsutomu, Keiji Takahashi, Nobuo Ohya, et al. "Ischemia-reperfusion lung injury in rabbits: mechanisms of injury and protection." American Journal of Physiology-Lung Cellular and Molecular Physiology 276, no. 1 (1999): L137—L145. http://dx.doi.org/10.1152/ajplung.1999.276.1.l137.

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To study the mechanisms responsible for ischemia-reperfusion lung injury, we developed an anesthetized rabbit model in which the effects of lung deflation, lung inflation, alveolar gas composition, hypothermia, and neutrophils on reperfusion pulmonary edema could be studied. Rabbits were anesthetized and ventilated, and the left pulmonary hilum was clamped for either 2 or 4 h. Next, the left lung was reperfused and ventilated with 100% oxygen. As indexes of lung injury, we measured arterial oxygenation, extravascular lung water, and the influx of a vascular protein (131I-labeled albumin) into

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Chen, Qihang, Jeffrey S. Klein, Gordon Gamsu, and W. Richard Webb. "High-resolution computed tomography of the mammalian lung." American Journal of Veterinary Research 53, no. 7 (1992): 1218–24. http://dx.doi.org/10.2460/ajvr.1992.53.7.1218.

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Summary High-resolution computed tomography (HRCT) was performed in 21 isolated animal lungs, from 4 mammalian species (pigs, rabbits, dogs, sheep). Gross and subgross central and peripheral lung morphology was determined by HRCT. Three distinct types of lungs can be identified, principally based on the extent of interlobular septal development; the relationship of major vessels to airways; and the thickness of the visceral pleura. Type-I lung is found in pigs, sheep, and cattle; type-II lung is found in rabbits, dogs, cats, and monkeys; and type-IH lung is found in human beings and horses.1 T

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Liao, Zhengchang, Xiaocheng Zhou, Ziqiang Luo, et al. "N-Methyl-D-aspartate Receptor Excessive Activation Inhibited Fetal Rat Lung DevelopmentIn VivoandIn Vitro." BioMed Research International 2016 (2016): 1–11. http://dx.doi.org/10.1155/2016/5843981.

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Background. Intrauterine hypoxia is a common cause of fetal growth and lung development restriction. Although N-methyl-D-aspartate receptors (NMDARs) are distributed in the postnatal lung and play a role in lung injury, little is known about NMDAR’s expression and role in fetal lung development.Methods. Real-time PCR and western blotting analysis were performed to detect NMDARs between embryonic days (E) 15.5 and E21.5 in fetal rat lungs. NMDAR antagonist MK-801’s influence on intrauterine hypoxia-induced retardation of fetal lung development was testedin vivo, and NMDA’s direct effect on feta

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Walker, A. M., B. C. Ritchie, T. M. Adamson, and J. E. Maloney. "Effect of changing lung liquid volume on the pulmonary circulation of fetal lambs." Journal of Applied Physiology 64, no. 1 (1988): 61–67. http://dx.doi.org/10.1152/jappl.1988.64.1.61.

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During fetal life the lung develops as a liquid-filled structure with low blood flow compared with postnatal life. We studied the effects of liquid expansion of the fetal lung by measuring vascular conductance in perfused lungs in situ and arterial diameters in excised lungs of fetal lambs. Pulmonary vascular conductance invariably rose as the lung was deflated from its initial volume; maximal deflation to residual volume increased conductance 122%. With reexpansion, conductance fell progressively, culminating in cessation of flow at lung volumes of twice the initial volume. These changes pers

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Deeb, G. M., C. M. Grum, M. J. Lynch, et al. "Neutrophils are not necessary for induction of ischemia-reperfusion lung injury." Journal of Applied Physiology 68, no. 1 (1990): 374–81. http://dx.doi.org/10.1152/jappl.1990.68.1.374.

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Ischemia-reperfusion lung injury limits lung transplantation. Neutrophil activation and/or xanthine oxidase-mediated purine degradation may cause toxic oxygen metabolite production and lung injury. We investigated whether circulating blood elements are involved in the pathogenesis of ischemia-reperfusion lung injury. Isolated rat lungs were perfused with physiological salt solution (PSS) stabilized with Ficoll until circulating blood elements were not detected in the lung effluent. Lungs were then rendered ischemic by stopping ventilation and perfusion for 45 min at room temperature. Lung inju

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Petroncini, Matteo, Elena Salvaterra, Leonardo Valentini, et al. "Donor Lungs’ Procurement Implementation with Ex Vivo Lung Perfusion in a Low-Volume Lung Transplant Center." Life 15, no. 1 (2024): 37. https://doi.org/10.3390/life15010037.

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(1) Background: Ex Vivo Lung Perfusion (EVLP) is a technique designed to assess and recondition marginal lungs, potentially expanding the donor pool and improving transplant outcomes (2) Methods: This retrospective study evaluated lung transplantation outcomes after EVLP. Donor lungs were assessed using the Toronto protocol, with data on hemodynamics, gas exchange, and perfusion parameters collected and analyzed. Post-transplant complications and survival rates were also examined. (3) Results: Over five years, 17 EVLP procedures were performed. Despite an improvement in lung function, 47% of d

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Barker, Kimberly A., Anukul T. Shenoy, Nicole Stauffer-Smith, et al. "Lung resident memory B cells are a common and functionally significant component of lung adaptive immunity." Journal of Immunology 204, no. 1_Supplement (2020): 85.8. http://dx.doi.org/10.4049/jimmunol.204.supp.85.8.

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Abstract Resident memory B cells (BRM) in influenza-recovered mouse lungs were recently described, but whether other types of infections elicit these cells is unknown. The relevance of BRM in human lungs and to lung immune defenses also remains unexplored. Using flow cytometry and immunofluorescence, we found that respiratory pneumococcal exposures in mice elicited lung BRM without concurrent tertiary lymphoid structure formation. Additionally, flow cytometry analysis of normal human lung tissue showed that human lungs are enriched compared to human blood for B cells bearing a resident memory

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He, L. S., S. W. Chang, P. Ortiz de Montellano, T. J. Burke, and N. F. Voelkel. "Lung injury in Fischer but not Sprague-Dawley rats after short-term hyperoxia." American Journal of Physiology-Lung Cellular and Molecular Physiology 259, no. 6 (1990): L451—L458. http://dx.doi.org/10.1152/ajplung.1990.259.6.l451.

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The Fischer rat is known for its susceptibility to develop liver necrosis when challenged with paraquat (Smith et al., J. Pharmacol. Exp. Ther. 235: 172-177, 1985). We postulated that other organs, specifically the lung, may also be more susceptible to injury and examined whether lungs from Fischer (F) rats were injured more easily when challenged with active oxygen species than Sprague-Dawley (SD) rat lungs. We aimed to investigate whether increased susceptibility to oxidant injury was related to differences in lung antioxidant defenses. Perfused lungs from both rat strains were challenged by

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Everaerts, Stephanie, Elise J. Lammertyn, Dries S. Martens, et al. "The aging lung: tissue telomere shortening in health and disease." Respiratory Research 19, no. 1 (2018): 95. https://doi.org/10.1186/s12931-018-0794-z.

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<strong>Background: </strong>Telomere shortening has been associated with several lung diseases. However, telomere length is generally measured in peripheral blood leucocytes rather than in lung tissue, where disease occurs. Consequently, telomere dynamics have not been established for the normal human lung nor for diseased lung tissue. We hypothesized an age- and disease-dependent shortening of lung tissue telomeres.<strong>Methods: </strong>At time of (re-)transplantation or autopsy, 70 explant lungs were collected: from unused donors (normal, <i>n</i> = 13) and patients with cystic fibrosis

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Wanczyk, Heather, Todd Jensen, Daniel J. Weiss, and Christine Finck. "Advanced single-cell technologies to guide the development of bioengineered lungs." American Journal of Physiology-Lung Cellular and Molecular Physiology 320, no. 6 (2021): L1101—L1117. http://dx.doi.org/10.1152/ajplung.00089.2021.

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Lung transplantation remains the only viable option for individuals suffering from end-stage lung failure. However, a number of current limitations exist including a continuing shortage of suitable donor lungs and immune rejection following transplantation. To address these concerns, engineering a decellularized biocompatible lung scaffold from cadavers reseeded with autologous lung cells to promote tissue regeneration is being explored. Proof-of-concept transplantation of these bioengineered lungs into animal models has been accomplished. However, these lungs were incompletely recellularized

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Hirai, T., K. A. McKeown, R. F. M. Gomes, and J. H. T. Bates. "Effects of lung volume on lung and chest wall mechanics in rats." Journal of Applied Physiology 86, no. 1 (1999): 16–21. http://dx.doi.org/10.1152/jappl.1999.86.1.16.

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To investigate the effect of lung volume on chest wall and lung mechanics in the rats, we measured the impedance (Z) under closed- and open-chest conditions at various positive end-expiratory pressures (0–0.9 kPa) by using a computer-controlled small-animal ventilator (T. F. Schuessler and J. H. T. Bates. IEEE Trans. Biomed. Eng. 42: 860–866, 1995) that we have developed for determining accurately the respiratory Z in small animals. The Z of total respiratory system and lungs was measured with small-volume oscillations between 0.25 and 9.125 Hz. The measured Z was fitted to a model that featur

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Maitra, Gayatri, Kevin Inchley, Richard J. Novick, Ruud A. W. Veldhuizen, James F. Lewis, and Fred Possmayer. "Acute lung injury and lung transplantation influence in vitro subtype conversion of pulmonary surfactant." American Journal of Physiology-Lung Cellular and Molecular Physiology 282, no. 1 (2002): L67—L74. http://dx.doi.org/10.1152/ajplung.2002.282.1.l67.

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The effects of surfactant treatment on surfactant subtype conversion after lung injury were examined. Dogs were subjected to hyperventilation for 8 h with or without surfactant treatment. Lungs were stored for 17 h, and the right lung was transplanted and reperfused for 6 h. Conversion of large aggregate (LA) surfactant to small aggregates was investigated using in vitro surface area cycling. LA from transplanted lungs (Transplant-LA) from the nontreated group converted more rapidly than Transplant-LA from the treated group. Transplant-LA from both groups converted more rapidly than LA from no

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