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Journal articles on the topic 'Luteolina'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

De Paiva, S. R., M. R. Figueiredo, and M. A. C. Kaplan. "Estudo fitoquímico de Plumbago auriculata Lam." Revista Fitos 1, no. 02 (2005): 64–68. http://dx.doi.org/10.32712/2446-4775.2005.26.

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A família Plumbaginaceae apresenta-se constituída por ervas, arbustos ou subarbustos de distribuição cosmopolita. Seus representantes apresentam produção metabólica caracterizada por naftoquinonas, flavonóides, terpenóides e esteróides, sendo os dois primeiros considerados marcadores quimiossistemáticos do grupo. O gênero Plumbago, tido como o mais representativo, compreende aproximadamente 10 espécies e tem sido alvo de estudos químicos e farmacológicos. Os estudos fitoquímicos de P. auriculata resultaram no isolamento de sitosterol, estigmasterol, 3-O-glicosilsitosterol, ácido palmítico, áci

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Rolim, Camilla Eduarda Lima, Ana Carolina Sousa Quaresma Quaresma, Cristian Kallahan Silva Chagas, José Otávio Carréra Silva Júnior, Paulo Ricardo de Souza Melo, and Maria Fâni Dolabela. "Estudo Farmacognóstico, Fitoquímio e Avaliação de Toxicidade de Justicia secunda vahl." Research, Society and Development 11, no. 12 (2022): e240111234344. http://dx.doi.org/10.33448/rsd-v11i12.34344.

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O estudo tem por objetivo descrever os resultados obtidos dos parâmetros de qualidade farmacognóstico, prospecção fitoquímica, toxicidade por estudos in silico e in vitro das folhas da Justicia secunda vahl. As folhas foram secas e pulverizadas, e os pós foram submetidos a testes farmacognóstico de pH, índice de espuma, determinação de umidade e densidade. Por meio de maceração com etanol obteve-se o extrato das folhas (EEF) e através de fracionamento por refluxo obteve-se as frações de hexano, diclorometano e metanol, seguido de prospecção fitoquímica do extrato etanólico por meio de precipit

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Torrenegra, Rubén, and Rubén Jiménez. "Estudio fitoquímico de hojas y flores de <i>Senna bicapsularis</i> (L) Roxburgh var. <i>bicapsularis</i>." Actualidades Biológicas 24, no. 76 (2017): 69–74. http://dx.doi.org/10.17533/udea.acbi.329584.

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El estudio fitoquímico de las hojas y flores de Senna bicapsularis dio como resultado el aislamiento de un flavonoide (luteolina), un alcohol (eicosanol) y una mezcla de los esteroles (estigmasterol y dehidroestigmasterol).

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QUEIROZ, VALÉRIA APARECIDA VIEIRA, KÊNIA GRASIELLE DE OLIVEIRA, CAROLINE LIBOREIRO PAIVA, et al. "RETENTION OF SOME FLAVONES AND FLAVANONES IN FLOUR, GRAIN AND BRAN OF SORGHUM DURING STORAGE." Revista Brasileira de Milho e Sorgo 17, no. 3 (2018): 522. http://dx.doi.org/10.18512/1980-6477/rbms.v17n3p522-534.

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ABSTRACT - Sorghum is associated with several functional benefits because it contains high levels of phenolic compounds, such as the flavonoids, flavones and flavanones. However, these compounds are sensitive to the period and conditions of storage. Thus, this work aimed to evaluate luteolin, apigenin, naringenin and eriodictyol retention in the sorghum genotypes SC319 (flour and grain) and TX430 (flour and bran) stored for 180 days at 4, 25 and 40 °C. These compounds were quantified by a high-performance liquid chromatograph equipped with a diode array detector. There was effect of the storag

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5

Diniz, Rosiane Aleixo, Adrielle Antônia da Silva, Giani Maria Cavalcante та Luiz Andrade Lins. "Atividade antitumoral e inibitória de topoisomerase II-α humana do flavonoide luteolina isolado de Prosopis juliflora". Research, Society and Development 11, № 5 (2022): e47811528220. http://dx.doi.org/10.33448/rsd-v11i5.28220.

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Este estudo objetivou avaliar a atividade antitumoral e inibitória da topoisomerase II-α humana do flavonoide luteolina isolado de Prosopis juliflora frente a células tumorais prostáticas (PC-3), com o intuito de investigação de novos fármacos de origem natural. Testes in vitro foram conduzidos com os extratos brutos das folhas frente as linhagens de células PC-3 e linhagem FGH. Os testes de citotoxicidade foram realizados através de MTT (3- (4,5-dimetiazol-2il) 2,5-difenil tetrazólio de brometo) com monitorização após 24 h de exposição das células tumorais e não tumorais a diferentes concentr

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6

Mora Flórez, L. S., D. Cabrera Rodríguez, and M. Hernández Carrión. "Desarrollo de una bebida aromática funcional a partir de polvos de mentol y luteolina obtenidos mediante Spray-Drying." Investigación y Desarrollo en Ciencia y Tecnología de Alimentos 8, no. 1 (2023): 435–44. http://dx.doi.org/10.29105/idcyta.v8i1.58.

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Las plantas aromáticas representan alrededor del 0,7% de las hierbas medicinales. Las más comunes son manzanilla (principio activo mayoritario: flavonoides como luteolina) y hierbabuena (principio activo mayoritario: mentol). Estas suelen consumirse en infusiones o tisanas usando "bolsas de té", pero el uso de estas bolsas conlleva tiempos de preparación relativamente largos, genera residuos y acarrea una alta probabilidad de ingerir microplásticos y nanoplásticos. En este trabajo se utilizaron polvos de mentol y luteolina obtenidos mediante secado por atomización a partir de una infusión de m

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7

Nicoly, Oyara Nunes Monteiro, Silva Amorim Jaqueline, Dennyson Silva Batista Davi, and Maria Cavalcante Giani. "FLAVONOIDES ISOLADOS DA MIMOSA PUDICA: UM ESTUDO BIOLÓGICO E FARMACOLÓGICO DE PREDIÇÃO IN SILICO." Revista Eletrônica Multidisciplinar de Investigação Científica v2. n.7, no. 09/08/2023 (2023): 11. https://doi.org/10.56166/remici.238v2n7156.

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O estudo químico de espécies vegetais é importante de suas ações e farmacológicas com o interesse para identificação de novas substâncias bioativas potencialmente viáveis para o desenvolvimento de novos fármacos. Neste contexto, a espécie <em>Mimosa pudica</em> aponta como uma fonte de substâncias bioativas visto a grande variedade de metabólitos secundários que apresenta. O objetivo deste trabalho foi realizar a predição <em>in silico</em> das atividades bio

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Vélez-Duncan, Carlos Arturo, Alejandro Uribe-Escobar, Rafael Pineda-Alemán, Neyder Contreras-Puentes, and Antistio Alviz-Amador. "Cribado virtual de metabolitos secundarios de Origanum vulgare y mejorana frente a NaV1.7 como anestésicos promisorios asociados a la vía neurosensitiva auditiva." ACTA DE OTORRINOLARINGOLOGÍA & CIRUGÍA DE CABEZA Y CUELLO 51, no. 1 (2023): 29–34. http://dx.doi.org/10.37076/acorl.v51i1.676.

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Introducción: en general, el orégano es una planta medicinal usada en los pueblos de la costa Caribe colombiana para tratar afecciones del aparato respiratorio y el oído externo debido a su potencial efecto antiinflamatorio, analgésico y antiséptico; sin embargo, esto no se ha validado mediante ensayos clínicos. Objetivo: realizar un cribado virtual basado en el acoplamiento molecular de metabolitos secundarios identificados en el Origanum vulgare y mejorana frente al receptor Nav1.7 para evaluar el potencial efecto anestésico a nivel del oído externo. Método: el presente es un estudio in sili

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Arévalo, Adriana dos Santos, Sarah Raquel Silveira da Silva Santiago, and Paulo Alexandre Lima Santiago. "Justicia acuminatissima (MIQ.) bremek (Acanthaceae): uma breve revisão bibliográfica sobre seus constituintes químicos com propriedades antioxidantes." OBSERVATÓRIO DE LA ECONOMÍA LATINOAMERICANA 22, no. 7 (2024): e5715. http://dx.doi.org/10.55905/oelv22n7-101.

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A Justicia acuminatissima, uma planta da família Acanthaceae, prospera na rica biodiversidade da Amazônia e é tradicionalmente utilizada na região para tratar diversas enfermidades. Este estudo realizou uma revisão bibliográfica dos constituintes químicos da J. acuminatissima, com foco em seus compostos antioxidantes. A revisão identificou triterpenos, flavonoides e derivados de luteolina como componentes principais. Embora haja poucos estudos sobre as propriedades antioxidantes desses compostos, a planta demonstra um potencial significativo para pesquisas futuras. Este estudo contribui e ince

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10

Putri, Lucienne Agatha Larasati Nugraha, Ni Luh Ari Krisma Anjani, Ni Putu Linda Laksmiani, and Ni Made Pitri Susanti. "In silico molecular docking of luteolin as a potential antihyperpigmentation agent." Pharmacy Reports 3, no. 1 (2024): 61. http://dx.doi.org/10.51511/pr.61.

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Excessive melanin synthesis, often triggered by overexposure to UV rays, is catalyzed by melanogenesis enzymes such as tyrosinase, tyrosinase-related protein 1, and D-dopachrome tautomerase. Derived from natural sources, the flavonoid compound luteolin is explored for its antihyperpigmentation potential. This study assesses luteolin’s efficacy as an antihyperpigmentation agent by analyzing its affinity and bond interactions with melanogenesis enzymes through an in silico approach. Molecular docking, facilitated by HyperChem 8 for test compound optimization and Chimera 1.11.1 for protein prepar

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11

Al-Saffar, Maha T., and Amer A. Taqa. "The effects of luteolin nanoparticles on the healing of extracted tooth socket in rabbits." Journal of Oral Research S, no. 1 (2019): 15–18. http://dx.doi.org/10.17126/joralres.2019.084.

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Objective: To evaluate the effects of luteolin nanoparticles on the process tooth socket healing in rabbits. Design: This study comprised five rabbits randomly assigned to control animal and experimental animals. Immediately after the extraction of an upper maxillary incisor, the alveolar sockets of experimental animals were treated with topical luteolin while alveolar sockets of the control group remained without treatment. The animals were sacrificed by decapitation with deep anesthesia seven days post tooth extraction. The tooth sockets were sectioned and stained with hematoxylin and eosin

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12

Hao, Jingwei, Nan Dong, Yifan Sun, et al. "Optimization of Extraction of Luteolin from Schisandra chinensis by Ionic Liquid–Enzyme Complex System and Antioxidant Study Analysis." Separations 11, no. 12 (2024): 354. https://doi.org/10.3390/separations11120354.

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The luteolin in Schisandra chinensis [Schisandraceae Schisandra (Turcz.) Baill.] were extracted by ultrasonic extraction assisted by an ionic liquid–enzyme composite system, and the content of luteolins was determined using high-performance liquid chromatography (HPLC). This process was initially conducted through a one-factor experiment and a Box–Behnken combinatorial design of response surface method. The extraction process was optimized, and the results demonstrated that the optimal extraction conditions were 13.31% enzyme addition, 0.53 mol/L ionic liquid concentration, 173.47 min ultrason

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13

Uysal Yeler, Gülcan, and Zeynep Göktaş. "Luteolin ve Apigenin Fitokimyasallarının Meme Kanseri Üzerine Etkileri." Journal of Nutrition and Dietetics 52, no. 2 (2024): 71–80. http://dx.doi.org/10.33076/2024.bdd.1877.

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Son yıllarda fitokimyasalların sağlık ve hastalıklara karşı etkileri konusunda araştırmalar artmaktadır ve en çok araştırılan konulardan birisi kanserdir. Meme kanseri meme hücrelerinin anormal büyümesi ile karakterizedir ve hormon cevaplarına göre sınıflandırılmaktadır. Bu sınıflandırma tedavinin yönünü ve seyrini etkilemektedir. Luteolin ve apigenin flavonlar sınıfında yer alan fitokimyasallardır ve sebzelerle sıklıkla alınmaktadır. Hem luteolinin hem de apigeninin anti-kanser özellikleri araştırılmaktadır. Bu çalışmada luteolin ve apigenin fitokimyasallarının meme kanserini hangi biyokimyas

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14

Zalamea Molina, Luis Felipe, Jenniffer Andreina Chila Álvarez, and Irina Suley Menéndez Realpe. "Obtención de AGNPS (nanopartículas de plata) vía síntesis verde con extracto de marcela (achyrocline satureioides), catálisis con actividad microbiana y antioxidante." Ingeniería Química y Desarrollo 2, no. 02 (2022): 01–09. https://doi.org/10.53591/iqd.v2i02.1750.

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Síntesis verde de NPs de plata, oro, cobre, son motivo de estudio investigativo que se realizan en la actualidad en la India, Indonesia y Ecuador como es el caso del presente trabajo a partir de extracto de Marcela (Achyrocline satureioides) y nitrato de plata. La metodología utilizada en la obtención de NPsAg es vía síntesis verde que se realizó con métodos de reducción iónica de los componentes químicos polifenoles y flavonoides como: ácido cafeico, ésteres de galangin-3-metil éter, quercetina; luteolina; 3-metoxi-quercetina y un nuevo chalcone: achyrobichalcone. Estos métodos de identificac

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15

Franco-Aguirre, Yesenia Damaris, Aidé Sáenz-Galindo, Claudia Magdalena López-Badillo, Raúl Rodríguez-Herrera, Adalí Oliva Castañeda-Facio, and Juan Alberto Ascacio-Valdés. "Extractos de Mentha piperita L. obtenidos por tecnologías hibridas." Pädi Boletín Científico de Ciencias Básicas e Ingenierías del ICBI 11, Especial (2023): 5–9. http://dx.doi.org/10.29057/icbi.v11iespecial.10233.

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Mentha piperita L. es una de las especies más demandadas a nivel mundial gracias a la presencia de propiedades de gran interés tales como: capacidad antioxidante, antifúngica y antibacterial. Existen diversas metodologías para la extracción de metabolitos secundarios, sin embargo, muchas de ellas resultan ser ineficientes ya que presentan tiempos de extracción considerables, bajos rendimientos y altos costos. En este trabajo se desarrolló una metodología de extracción hibrida mediante la asistencia de ultrasonido-microondas para la obtención de metabolitos secundarios de hojas secas de Mentha

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Martins, Márcia Cristina Teixeira, Delia Rodriguez-Amaya, Marcelo Antonio Morgano, and Maria Isabel Rodrigues. "Otimização e validação de metodologia analítica para determinação de flavonóis e flavonas por CLAE em pólen apícola utilizando-se Análise de Superfície de Resposta." Revista do Instituto Adolfo Lutz 70, no. 2 (2011): 122–31. http://dx.doi.org/10.53393/rial.2011.v70.32561.

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Foi otimizada a metodologia analítica para determinar quatro flavonóis: miricetina (M), quercetina (Q), kanferol (K) e isoramnetina (I); e duas flavonas: luteolina (L) e apigenina (A) em amostras de pólen apícola desidratado produzidas em três estados brasileiros: Bahia (BA), São Paulo (SP) e Santa Catarina (SC). Delineamento Composto Central Rotacional (DCCR) foi utilizado para investigar os efeitos da concentração de HCl e do tempo de hidrólise sobre a concentração de cada flavonoide. A condição ótima encontrada para extração/hidrólise dos flavonoides estudados foi: 1,0M HCl/30 minutos. A me

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Cobos Cervantes, Paola, Samantha Armijo Martínez, Norma Cavazos Rocha, David Paniagua Vega, and Omar J. Portillo Castillo. "Desarrollo de un método de extracción por la técnica de MEPS para polifenoles en miel." Investigación y Desarrollo en Ciencia y Tecnología de Alimentos 8, no. 1 (2023): 872–81. http://dx.doi.org/10.29105/idcyta.v8i1.110.

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Se desarrolló y validó un método mediante la técnica de microextracción con sorbente empacado (MEPS) para la extracción de polifenoles en miel y su análisis mediante cromatografía de líquidos de alta resolución. El cartucho C18 resultó ser el más adecuado para la extracción simultánea de un mayor número de polifenoles, tales como ácido protocatechuico, ácido cafeico, ácido p-cumárico, ácido trans-ferúlico, ácido rosmarínico, quercetina, luteolina, apigenina y kaempferol. Para la optimización del volumen y tipo de disolvente en el paso de elución, se trabajó con un diseño de experimentos median

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Marchiori, Beatriz Andrade, Danielle Cristine Mota Ferreira, Ana Luísa de Castro Borges, Victória Mateus Frossard, Vanessa Aglaê Martins Teodoro, and Kely de Paula Correa. "POTENCIAL DA SALSA (PETROSELINUM CRISPUM) COMO AGENTE ANTIOXIDANTE E ANTIMICROBIANO EM ALIMENTOS." Revista Ibero-Americana de Humanidades, Ciências e Educação 1, no. 4 (2025): 189–97. https://doi.org/10.51891/rease.v1i4.18504.

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A deterioração microbiana dos alimentos e as doenças de transmissão hídrica e alimentar são questões que afetam a saúde pública. O uso prolongado de conservantes sintéticos tem gerado atenção devido a potenciais efeitos adversos. A salsa (Petroselinum crispum) é fonte de antioxidantes e antimicrobianos, que pode auxiliar na manutenção da qualidade e da segurança dos alimentos, podendo representar uma alternativa natural para a indústria, alinhando-se à demanda por produtos mais saudáveis. O objetivo desta revisão de literatura, foi investigar estudos que apresentam o potencial antioxidante e a

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Che, Denis Nchang, Byoung Ok Cho, Ji-su Kim, Jae Young Shin, Hyun Ju Kang, and Seon Il Jang. "Effect of Luteolin and Apigenin on the Production of Il-31 and Il-33 in Lipopolysaccharides-Activated Microglia Cells and Their Mechanism of Action." Nutrients 12, no. 3 (2020): 811. http://dx.doi.org/10.3390/nu12030811.

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Microglia cells are resident cells of the central nervous system (CNS) charged with modulating inflammation in the CNS. Overstimulation of microglia cells continuously releases inflammatory mediators that contribute to neurodegenerative diseases. Apigenin and Luteolin are flavonoids with reported anti-inflammatory activities. However, their effects on IL-31 and IL-33 production in microglial cells are unknown. Here, we investigated the effects of apigenin and luteolin on the production of IL-31 and IL-33 by microglia cells. SIM-A9 microglial cells were pre-treated with apigenin or luteolin and

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Blank, Daiane Einhardt, Gabriela Hörnke Alves, Rogerio Antonio Freitag, Rayra Almeida Correa, Silvia De Oliveira Hubner, and Marlete Brum Cleff. "COMPOSIÇÃO QUÍMICA E CITOTOXICIDADE DE Origanum vulgare L. E Rosmarinus officinalis L." Science And Animal Health 4, no. 2 (2017): 117. http://dx.doi.org/10.15210/sah.v4i2.6569.

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Levando em consideração o potencial antimicrobiano de produtos naturais, o presente estudo teve como objetivo estudar a composição química e citotoxicidade de óleos essenciais e extratos aquoso e etanólico de Origanum vulgare e Rosmarinus officinalis. A identificação química dos óleos essenciais foi realizada por cromatografia gasosa com detector de ionização de chama (GC/FID) e dos extratos por cromatografia líquida de alta eficiência (CLAE). A citotoxicidade foi medida pelo método do MTT nas linhagens celulares MBDK, RK13, MDCK e CRFK. Os principais compostos detectados nos óleos de O. vulga

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Rakoczy, Katarzyna, Justyna Kaczor, Adam Sołtyk, et al. "Application of Luteolin in Neoplasms and Nonneoplastic Diseases." International Journal of Molecular Sciences 24, no. 21 (2023): 15995. http://dx.doi.org/10.3390/ijms242115995.

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Researchers are amazed at the multitude of biological effects of 3′,4′,5,7-tetrahydroxyflavone, more commonly known as luteolin, as it simultaneously has antioxidant and pro-oxidant, as well as antimicrobial, anti-inflammatory, and cancer-preventive, properties. The anticancer properties of luteolin constitute a mosaic of pathways due to which this flavonoid influences cancer cells. Not only is it able to induce apoptosis and inhibit cancer cell proliferation, but it also suppresses angiogenesis and metastasis. Moreover, luteolin succeeds in cancer cell sensitization to therapeutically induced

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Araujo Murcia, Héctor Mauricio, Rocío de Los Ángeles Franco Hernández, and Andrea Sofía Ortiz Tobar. "Rol de los polifenoles en la prevención y tratamiento del cáncer de mama no metastásico." Alerta, Revista científica del Instituto Nacional de Salud 8, no. 1 (2025): 96–102. https://doi.org/10.5377/alerta.v8i1.19202.

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El cáncer de mama es una de las neoplasias diagnosticadas con mayor frecuencia en las mujeres a nivel mundial y representa la segunda causa de muerte en este grupo poblacional. La prevención primaria es esencial para la detección temprana del cáncer de mama con énfasis en el tamizaje anual para brindar un tratamiento oportuno, basado en un manejo multidisciplinario que incluye las áreas de cirugía, oncología, patología y nutrición. Con el objetivo de estudiar el rol anticarcinogénico de los polifenoles en el cáncer de mama no metastásico, se realizó una búsqueda bibliográfica utilizanbdo las b

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Huber, Lísia S., Delia B. Rodrigues-Amaya, and Maria I. Rodrigues. "Otimização e validação de metodologia analítica para determinação de flavonóis e flavonas por CLAE em hortaliças." Revista do Instituto Adolfo Lutz 66, no. 2 (2007): 142–51. http://dx.doi.org/10.53393/rial.2007.66.32824.

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O objetivo deste trabalho foi otimizar a metodologia analítica para determinação de flavonóis e flavonas em hortaliças. A hidrólise foi otimizada utilizando-se Delineamento Composto Central Rotacional (DCCR) para investigar os efeitos da concentração de HCl e do tempo de hidrólise. Essa etapa foi realizada simultaneamente com a extração por metanol aquoso 50%, em refluxo a 90ºC. Foi utilizado cromatógrafo líquido Waters com coluna Nova-Pak C18 e detector de arranjo de diodos. Os compostos estudados foram miricetina (M), quercetina (Q), kaempferol (K), luteolina (L) e apigenina (A). As condiçõe

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Muruganathan, Nandakumar, Anand Raj Dhanapal, Venkidasamy Baskar, et al. "Recent Updates on Source, Biosynthesis, and Therapeutic Potential of Natural Flavonoid Luteolin: A Review." Metabolites 12, no. 11 (2022): 1145. http://dx.doi.org/10.3390/metabo12111145.

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Nature gives immense resources that are beneficial to humankind. The natural compounds present in plants provide primary nutritional values to our diet. Apart from food, plants also provide chemical compounds with therapeutic values. The importance of these plant secondary metabolites is increasing due to more studies revealing their beneficial properties in treating and managing various diseases and their symptoms. Among them, flavonoids are crucial secondary metabolite compounds present in most plants. Of the reported 8000 flavonoid compounds, luteolin is an essential dietary compound. This

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Martinez-Gonzalez, Alejandra Isabel, Ángel Gabriel Díaz-Sánchez, Laura Alejandra De la Rosa, Ismael Bustos- Jaimes, Alma A. Vazquez-Flores, and Emilio Alvarez-Parrilla. "Inhibición de lipasa pancreática por flavonoides: importancia del doble enlace C2=C3 y la estructura plana del anillo C//Inhibition of pancreatic lipase by flavonoids: relevance of the C2=C3 double bond and C-ring planarity." Biotecnia 22, no. 2 (2020): 50–60. http://dx.doi.org/10.18633/biotecnia.v22i2.1245.

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Lipasa pancreática es una enzima clave en el metabolismo de lípidos. Los flavonoides son compuestos bioactivos de gran relevancia debido a sus interacciones con enzimas digestivas. Se evaluó la actividad de lipasa pancreática en presencia de flavonoides. Mediante espectroscopía UVVisible se determinó que el mejor inhibidor fue quercetina, seguido de rutina > luteolina > catequina > hesperetina, con valores de IC50 de 10.30, 13.50, 14.70, 28.50 y 30.50 μM, respectivamente. Todos los flavonoides mostraron una inhibición mixta, excepto catequina que mostró una inhibición acompetitiva. La

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Song, Youngsun, and Chung-Mu Park. "The Anti-Atherogenic Activity of Luteolin and Luteolin-7-O-glucoside in High-Fat Diet-Administered Hyperhomocysteinemia-Induced C57BL/6J Mice." Current Developments in Nutrition 4, Supplement_2 (2020): 476. http://dx.doi.org/10.1093/cdn/nzaa045_109.

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Abstract Objectives The anti-atherogenic activity of luteolin and one of its glycoside form, luteolin-7-O-glucoside, was compared in high fat fed homocysteinemia-induced C57BL/6J mice. Methods Forty male C57BL/6J mice (12 wks) were divided into 4 groups; negative control group, homocystein (Hcy) control group, luteolin and luteolin-7-O-glucoside groups and fed by modified AIN-93 with 45% fat and 0.5% cholesterol. Flavones were administered by oral gavage (50 mg/Kg BW) and Hcy (0.9 g/L) were provided in drinking water for 6 weeks. Results The serum concnetrations of Hcy, TG, cholesterol, TNF-α

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Maia, Amazile Biagioni. "Valor nutricional do caldo de cana e potencial nutracêutico do caná – bebida fermentada do caldo de cana." Research, Society and Development 11, no. 3 (2022): e33811326112. http://dx.doi.org/10.33448/rsd-v11i3.26112.

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O Brasil é o maior produtor mundial de cana-de-açúcar, sendo o caldo destinado principalmente à produção de açúcar, álcool combustível e cachaça industrial. Em menor proporção, milhares de produtores cultivam cana de açúcar em escala rural, para produção da cachaça de alambique, açúcar mascavo, rapadura e melado. Nos últimos anos, esses produtores têm buscado opções que, além de ampliar o leque de produtos, permitam agregar mais valor às suas propriedades e canaviais. Nesse contexto, tem sido considerada a viabilidade de produção do caldo de cana fermentado, como bebida final, similar ao vinho

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Castro-González, Maribeb, Diana I. Gómez López, Laura Sánchez Valencia, Andrés Acosta Chaparro, and Ericsson Coy-Barrera. "Enfermedad del desgaste en praderas de Thalassia testudinum (Hydrocharitaceae) y su relación con el perfil metabólico." Revista de Biología Tropical 70 (March 3, 2022): 149–72. http://dx.doi.org/10.15517/rev.biol.trop..v70i1.46183.

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Introducción: Los protistas del género Labyrinthula causan la denominada “Enfermedad del desgaste” en el pasto marino, Thalassia testudinum. Desde el 2008 los monitoreos en el Caribe colombiano han mostrado variación espacial y temporal en la incidencia de la enfermedad, pero sin la alta mortalidad observada en otras regiones del mundo. Objetivo: Analizar algunos parámetros epidemiológicos en T. testudinum y comparar metabolitos entre plantas sanas e infectadas. Métodos: Registramos la severidad, incidencia y prevalencia de esta enfermedad en el Parque Nacional Natural Tayrona e Isla de Provid

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Taweesap, Pongsakorn, Prapassorn Potue, Juthamas Khamseekaew та ін. "Luteolin Relieves Metabolic Dysfunction-Associated Fatty Liver Disease Caused by a High-Fat Diet in Rats Through Modulating the AdipoR1/AMPK/PPARγ Signaling Pathway". International Journal of Molecular Sciences 26, № 8 (2025): 3804. https://doi.org/10.3390/ijms26083804.

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Metabolic dysfunction-associated fatty liver disease (MAFLD) is a significant global public health issue. Luteolin possesses several beneficial biological properties, including antioxidation and anti-inflammation. This study investigated luteolin’s effect and potential mechanisms on MAFLD in high-fat diet (HFD)-fed rats. Rats were administered an HFD supplemented with fructose for 12 weeks to induce MAFLD. After that, the HFD-fed rats were given either luteolin (50 or 100 mg/kg/day) or metformin (100 mg/kg/day) for 4 weeks. Luteolin improved metabolic parameters induced by the HFD, since it de

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Arampatzis, Athanasios S., Aspasia Pampori, Eleftheria Droutsa, et al. "Occurrence of Luteolin in the Greek Flora, Isolation of Luteolin and Its Action for the Treatment of Periodontal Diseases." Molecules 28, no. 23 (2023): 7720. http://dx.doi.org/10.3390/molecules28237720.

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Higher plants possess the ability to synthesize a great number of compounds with many different functions, known as secondary metabolites. Polyphenols, a class of flavonoids, are secondary metabolites that play a crucial role in plant adaptation to both biotic and abiotic environments, including UV radiation, high light intensity, low/high temperatures, and attacks from pathogens, among others. One of the compounds that has received great attention over the last few years is luteolin. The objective of the current paper is to review the extraction and detection methods of luteolin in plants of

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Yoong, Wong Theen, Shuit Siew Choong, Mohd Sofian Omar Fauzee, Zuraini Ahmad, and Muhammad Nazrul Hakim. "Luteolin Suppresses Endothelial Permeability and Nitric Oxide Scavenging Effects." Indonesian Biomedical Journal 16, no. 5 (2024): 427–33. http://dx.doi.org/10.18585/inabj.v16i5.3198.

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BACKGROUND: Numerous inflammatory diseases are linked to increased endothelial permeability through the nitric oxide (NO) flux in endothelial cells. Luteolin has in vitro and in vivo anti-inflammatory properties and has been reported to reduce endothelial permeability. However, the exact mechanism/s are yet to be determined. Thus, the present study was conducted to investigate the effects of luteolin in reducing endothelial permeability in vitro using bradykinin (BK) or sodium nitroprusside (SNP) through the NO pathway and the NO radical scavenging property of luteolin.METHODS: Human umbilical

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Huang, Renxuan, Rui Dong, Nan Wang, Beiwu Lan, Hongyang Zhao, and Yufei Gao. "Exploring the Antiglioma Mechanisms of Luteolin Based on Network Pharmacology and Experimental Verification." Evidence-Based Complementary and Alternative Medicine 2021 (November 27, 2021): 1–18. http://dx.doi.org/10.1155/2021/7765658.

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Luteolin, a natural flavone compound, exists in a variety of fruits and vegetables, and its anticancer effect has been shown in many studies. However, its use in glioma treatment is hampered due to the fact that the underlying mechanism of action has not been fully explored. Therefore, we elucidated the potential antiglioma targets and pathways of luteolin systematically with the help of network pharmacology and molecular docking technology. The druggability of luteolin, including absorption, excretion, distribution, and metabolism, was assessed via the Traditional Chinese Medicine Systems Pha

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B. R, Premalatha, Suman Basavaraju, SubbaRao V. Madhunapantula, Hemanth Kumar S, Veena H. R, and Usha Hegde. "Therapeutic Potential of Luteolin in Periodontal Therapy- A Scoping Review Protocol." Biomedical and Pharmacology Journal 17, no. 4 (2024): 2295–300. https://doi.org/10.13005/bpj/3025.

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Objective: This scoping review is aimed at evaluating the therapeutic potential of luteolin in periodontal therapy. Introduction: Periodontal disease is a destructive, inflammatory process of the tooth-supporting tissues resulting frequently in tooth loss. Current periodontal therapy includes surgical and non-surgical strategies. Plant-based adjuvant therapies have recently gained popularity due to their potent pharmacological qualities and negligible side effects. Luteolin is a flavonoid found in many herbs, vegetables, and fruits. It exhibits several biological activities useful in fighting

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Han, Ming, Yuting Lu, Yunhua Tao та ін. "Luteolin Protects Pancreatic β Cells against Apoptosis through Regulation of Autophagy and ROS Clearance". Pharmaceuticals 16, № 7 (2023): 975. http://dx.doi.org/10.3390/ph16070975.

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Diabetes, which is mainly characterized by increased apoptosis and dysfunction of beta (β) cells, is a metabolic disease caused by impairment of pancreatic islet function. Previous studies have demonstrated that death-associated protein kinase-related apoptosis-inducing kinase-2 (Drak2) is involved in regulating β cell survival. Since natural products have multiple targets and often are multifunctional, making them promising compounds for the treatment of diabetes, we identified Drak2 inhibitors from a natural product library. Among the identified products, luteolin, a flavonoid, was found to

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de Aguiar, Antônio Sérgio Nakao, Lucas Barbosa Ribeiro de Carvalho, Clayson Moura Gomes, Murillo Moraes Castro, Frederico Severino Martins, and Leonardo Luiz Borges. "Computational Insights into the Antioxidant Activity of Luteolin: Density Functional Theory Analysis and Docking in Cytochrome P450 17A1." Pharmaceuticals 18, no. 3 (2025): 410. https://doi.org/10.3390/ph18030410.

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Background: Luteolin, a flavonoid with well-documented antioxidant properties, has garnered significant attention for its potential therapeutic effects. Objectives: This study aims to investigate the antioxidant properties of luteolin under the influence of solvents, utilizing computational techniques to elucidate its interactions and its potential role as a modulator of enzymatic activities, particularly with Cytochrome 17A1. Methods: Density Functional Theory (DFT) calculations were employed to determine luteolin’s electronic and structural characteristics. Key aspects analyzed included elec

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Ibarra-Berumen, Jorge, Cynthia Ordaz-Pichardo, and Martha Rosales-Castro. "Evaluación fenólica y antioxidante en madera de Prosopis laevigata y corteza de Acrocarpus fraxinifolius." Madera y Bosques 29, no. 2 (2023): e2922503. http://dx.doi.org/10.21829/myb.2023.2922503.

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Durante el aprovechamiento forestal de las especies Prosopis laevigata (mezquite) y Acrocarpus fraxinifolius (cedro rosado) se generan productos de desecho, tanto de madera como de corteza. Este material contiene metabolitos secundarios como los compuestos fenólicos, con potencial en áreas farmacéuticas. Este trabajo tuvo como objetivo obtener extractos de madera de P. laevigata y corteza de A. fraxinifolius, mediante diferentes disolventes de extracción y distintas temperaturas, con el fin de encontrar las condiciones para obtener el mayor rendimiento, la mayor cantidad de fenoles, flavonoide

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Chemchame, Younes, Mourid Fatim Zahra, Mehdi El Bouchti, and Aboubakr Kharchafi. "Bio-Antifelting Treatment of Wool-Fiber Based on Ficin: Improvement and Effect on Dyeing with the Reseda luteola Plant." AATCC Journal of Research 8, no. 3 (2021): 40–48. http://dx.doi.org/10.14504/ajr.8.3.6.

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The objective of this study was to assess the effect of ficin enzyme as a new antifelting agent acting on wool yarn and fabric. The treatment effect on the dyeing efficiency of luteoline colorant that was extracted from weld (Reseda luteola) was also evaluated. The structural properties of antifelted and non-antifelted fibers were evaluated by scanning electron microscopy (SEM) and Fourier transform infrared (FTIR) spectroscopy. An optimal enzymatic process for antifelting and shrink proofing was achieved at 40 °C for 3 h in alkaline medium at pH 10. The treatment increased the dye absorbance

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Talavera Apaza, Mirelia Janeth. "Efecto antibacteriano sobre el Streptococcus mutans (ATCC®25175) y perfil de compuestos fenólicos de la manzanilla (Matricaria chamomilla L.) cultivada en Puno." Revista Investigaciones Altoandinas - Journal of High Andean Investigation 17, no. 2 (2015): 173. http://dx.doi.org/10.18271/ria.2015.110.

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<p>Los objetivos de esta investigación fueron caracterizar el perfil de compuestos fenólicos del extracto y la infusión de manzanilla por cromatografía liquida de alta performancia (HPLC-DAD) y evaluar el efecto antibacteriano de la infusión de manzanilla sobre el <em>Streptococcus mutans</em> (ATCC 25175), utilizando el test de difusión en disco. Los principales compuestos fenólicos encontrados corresponden a los flavonoides, seguidos por los ácidos fenólicos. El contenido total de compuestos fenólicos en el extracto y en la infusión fueron 37,51 y 26. 95 mg/g de peso seco (

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Moreira, João de Brito, Naíra Assunção De Sá Holanda, Sarah Raquel Silveira Da Silva Santiago, et al. "LEVANTAMENTO BIBLIOGRÁFICO DOS COMPOSTOS QUÍMICOS COM ATIVIDADE ANTIOXIDANTE E ANTIMICROBIANA PRESENSTES EM Arrabidaea chica (HUMB. & BONPL.) B. VERLOT (BIGNONIACEAE)." REVISTA FOCO 17, no. 1 (2024): e4141. http://dx.doi.org/10.54751/revistafoco.v17n1-073.

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A espécie vegetal Arrabidaea chica, popularmente como pariri, cipó-pau ou crajiru, destaca-se por suas diversas propriedades medicinais. Dentre elas, a possibilidade de uso no tratamento de inflamações uterinas, sífilis, leucemia, conjuntivites, diarreias, cólicas intestinais, psoríase, impigens, úlceras, prevenção contra cáries dentre outros. Apesar de ser um organismo amplamente estudado, o número de monografias, dissertações, teses e artigos que abordam essa espécie nos últimos dez anos não ultrapassa cinquenta e cinco, e essa quantidade é ainda menor no Amazonas. Nesse contexto, este estud

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Cerrato, Alfonso, Diana De Santis, and Mauro Moresi. "Production of luteolin extracts fromReseda luteola and assessment of their dyeing properties." Journal of the Science of Food and Agriculture 82, no. 10 (2002): 1189–99. http://dx.doi.org/10.1002/jsfa.1160.

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Cho, Byoung Ok, Hong Hua Yin, Chong Zhou Fang, et al. "Synergistic Anti-inflammatory Effect of Rosmarinic Acid and Luteolin in Lipopolysaccharide-Stimulated RAW264.7 Macrophage Cells." Korean Journal of Food Science and Technology 47, no. 1 (2015): 119–25. http://dx.doi.org/10.9721/kjfst.2015.47.1.119.

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Lim, Yong. "Effects of Luteolin on Fetal Bovine Serum-induced Events in Cultured Rat Vascular Smooth Muscle Cells." Journal of Life Science 22, no. 12 (2012): 1595–99. http://dx.doi.org/10.5352/jls.2012.22.12.1595.

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Seo, Jiwon, and Jonghwi Lee. "Spherical Evaporative Crystallization of Luteolin in Presence of Polymers." Polymer Korea 43, no. 4 (2019): 640–45. http://dx.doi.org/10.7317/pk.2019.43.4.640.

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Długosz, Ewa, Jakub Misiak, Kinga Grabowska, and Izabela Jasicka-Misiak. "Neuroprotective properties of polyphenolic substances of honey and bee pollen." Farmacja Polska 80, no. 4 (2024): 241–53. http://dx.doi.org/10.32383/farmpol/192280.

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Wprowadzenie. Choroby neurodegeneracyjne występujące najczęściej u osób starszych stanowią globalny problem, na który nie ma skutecznego leczenia przyczynowego. Do jednych z najczęściej opisywanych chorób starzejącej się populacji należą: choroba Alzheimera (AD), choroba Parkinsona (PD), choroba Huntingtona (HD) i stwardnienie zanikowe boczne (ALS). Do patogenezy chorób neurodegeneracyjnych prowadzi wiele czynników biologicznych, takich jak stres oksydacyjny, dysfunkcja mitochondriów, zapalenie neuronów i gleju, akumulacja białek i aktywacja szlaków apoptotycznych. Ponieważ zaburzenia neurodeg

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Cox, Philip J., Yashodharan Kumarasamy, Lutfun Nahar, Satyajit D. Sarker, and Mohammad Shoeb. "Luteolin." Acta Crystallographica Section E Structure Reports Online 59, no. 7 (2003): o975—o977. http://dx.doi.org/10.1107/s1600536803013229.

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BAUMANN, LESLIE S. "Luteolin." Skin & Allergy News 40, no. 9 (2009): 17. http://dx.doi.org/10.1016/s0037-6337(09)70433-4.

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Wang, X. W. "Luteolin." Drugs of the Future 25, no. 2 (2000): 146. http://dx.doi.org/10.1358/dof.2000.025.02.566443.

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Śliwka-Kaszyńska, Magdalena, Iwona Anusiewicz, and Piotr Skurski. "The Mechanism of a Retro-Diels–Alder Fragmentation of Luteolin: Theoretical Studies Supported by Electrospray Ionization Tandem Mass Spectrometry Results." Molecules 27, no. 3 (2022): 1032. http://dx.doi.org/10.3390/molecules27031032.

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The mechanisms of retro-Diels–Alder fragmentation of luteolin are studied theoretically using the Density Functional Theory method (B3LYP hybrid functional) together with the 6-311++G(d,p) basis set and supported by electrospray ionization tandem mass spectrometry (ESI-MS) results. The reaction paths leading to the formation of 1,3A− and 1,3B− fragment ions observed as the main spectral features in the ESI-MS spectrum are described and discussed, including the structures of the transition states and intermediate products. The heights of the activation energy barriers which have to be overcome

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Jain, Roopesh, and Archana Tiwari. "Monograph: Luteolin." Matrix Science Medica 4, no. 3 (2020): 88. http://dx.doi.org/10.4103/mtsm.mtsm_14_20.

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Park, Hyun Soo, and Yung Hyun Choi. "Induction of Apoptosis by Combination Treatment with Luteolin and TRAIL in T24 Human Bladder Cancer Cells." Journal of the Korean Society of Food Science and Nutrition 42, no. 9 (2013): 1363–69. http://dx.doi.org/10.3746/jkfn.2013.42.9.1363.

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