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Journal articles on the topic 'LV diastolic and LV systolic dysfunction'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Kusumoto, Go, Kenji Shigematsu, Kouhei Iwashita, Kenji Tominaga, Takaaki Totoki, and Ken Yamaura. "Association between Preoperative Cardiac Left Ventricular Dysfunction and Perioperative Intraaortic Balloon Pump in Patients Undergoing Off-Pump Coronary Artery Bypass Surgery." Heart Surgery Forum 20, no. 4 (2017): 147. http://dx.doi.org/10.1532/hsf.1808.

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Background: Prophylactic use of intraaortic balloon pump (IABP) reduces hospital mortality in patients with left ventricular (LV) systolic dysfunction undergoing coronary artery bypass surgery (CABG); however, its association in patients with LV diastolic dysfunction is unclear. This retrospective study investigated the association between preoperative LV function and perioperative use of IABP in patients undergoing off-pump CABG (OPCAB) at a university hospital.Methods: 100 consecutive patients who underwent OPCAB between January 1, 2011 and August 31, 2014 were studied. Preoperative LV funct

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2

Rao, Tarun, Mohit Karwa, and Anil Wanjari. "Left ventricular dysfunction among chronic kidney disease patients: a cross sectional study." International Journal of Advances in Medicine 5, no. 5 (2018): 1093. http://dx.doi.org/10.18203/2349-3933.ijam20183390.

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Background: There is a significant worldwide burden of CKD; which is likely to increase further. Cardiovascular diseases constitute major cause of morbidity and mortality in CKD. LV dysfunction may be present despite the asymptomatic phase during the early stages of CKD. Thus, early detection of LV dysfunction and targeted interventions can improve prognosis in CKD.Methods: This cross-sectional study was conducted among 250 CKD admitted patients. Echocardiographic examination was done to determine the systolic and diastolic function of LV. For LV systolic function ejection fraction and % fract

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3

Mamatha, Shree C., KS Prashanth, and B. Girija. "Effect of obesity and hypertension on left ventricular geometry and function among asymptomatic Indian adults." Bioinformation 20, no. 8 (2024): 862–67. http://dx.doi.org/10.6026/973206300200862.

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Hypertension & obesity are important independent predictors of cardiovascular morbidity & mortality specifically left ventricular (LV) functions. With the Objectives to examine the effect of obesity & hypertension on echocardiographic parameters of geometry, systolic, and diastolic functions of left ventricle in asymptomatic adults the cross-sectional study was conducted with 100 individuals (60 male & 40 female). Their Blood Pressure & Body Mass Index was recorded following which they were divided into obese normotensives & non-obese hypertensive. Echocardiographic par

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4

Choi, Sun Ryoung, Young-Ki Lee, Hayne Cho Park, et al. "Clinical significance of central systolic blood pressure in LV diastolic dysfunction and CV mortality." PLOS ONE 16, no. 5 (2021): e0250653. http://dx.doi.org/10.1371/journal.pone.0250653.

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Background and aims Cardiovascular (CV) disease is the major cause of death in patients with end-stage kidney disease (ESKD). Left ventricular (LV) diastolic dysfunction reflects LV pressure overload and is common in patients with ESKD. Recently, there have been studies on the usefulness of central blood pressure (BP); however, the relationship between central BP and LV diastolic dysfunction is not clear in dialysis patients with preserved systolic function. The purpose of this study was to investigate the clinical implication of central BP on LV diastolic dysfunction and CV mortality in the E

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Ballo, Piercarlo, Irene Betti, Giuseppe Mangialavori, Leandro Chiodi, Gherardo Rapisardi, and Alfredo Zuppiroli. "Peripartum Cardiomyopathy Presenting with Predominant Left Ventricular Diastolic Dysfunction: Efficacy of Bromocriptine." Case Reports in Medicine 2012 (2012): 1–6. http://dx.doi.org/10.1155/2012/476903.

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Management of patients with peripartum cardiomyopathy (PPCM) is still a major clinical problem, as only half of them or slightly more show complete recovery of left ventricular (LV) function despite conventional evidence-based treatment for heart failure. Recent observations suggested that bromocriptine might favor recovery of LV systolic function in patients with PPCM. However, no evidence exists regarding its effect on LV diastolic dysfunction, which is commonly observed in these patients. Tissue Doppler (TD) is an echocardiographic technique that provides unique information on LV diastolic

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6

YIP, Gabriel W., Yan ZHANG, Peggy Y. TAN, et al. "Left ventricular long-axis changes in early diastole and systole: impact of systolic function on diastole." Clinical Science 102, no. 5 (2002): 515–22. http://dx.doi.org/10.1042/cs1020515.

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Impaired long-axis motion is a sensitive marker of systolic myocardial dysfunction, but no data are available that relate long-axis changes in systole with those in diastole, particularly in subjects with diastolic dysfunction and a ‘normal’ left ventricular (LV) ejection fraction. A total of 311 subjects (including 105 normal healthy volunteers) aged 20-89 years with variable degrees of systolic function (LV ejection fraction range 0.15-0.84) and diastolic function were studied using tissue Doppler echocardiography and M-mode echocardiography to determine mean mitral annular amplitude and pea

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Pagel, Paul S., Dermot Lowe, Douglas A. Hettrick, et al. "Isoflurane, but Not Halothane, Improves Indices of Diastolic Performance in Dogs with Rapid Ventricular, Pacing-induced Cardiomyopathy." Anesthesiology 85, no. 3 (1996): 644–54. http://dx.doi.org/10.1097/00000542-199609000-00025.

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Background The left ventricular (LV) mechanical effects of isoflurane and halothane were examined in dogs with rapid LV pacing-induced cardiomyopathy. These experiments tested the hypothesis that isoflurane and halothane differentially enhance indices of diastolic performance in dogs with moderate LV dysfunction. Methods Eight dogs were chronically instrumented for measurement of LV and aortic pressures, subendocardial segment length, and cardiac output. Contractility was quantified by preload recruitable stroke work (Mw). Diastolic function was evaluated with a time constant of isovolumic rel

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8

Ihara, T., K. Komamura, Y. T. Shen, et al. "Left ventricular systolic dysfunction precedes diastolic dysfunction during myocardial ischemia in conscious dogs." American Journal of Physiology-Heart and Circulatory Physiology 267, no. 1 (1994): H333—H343. http://dx.doi.org/10.1152/ajpheart.1994.267.1.h333.

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We studied the initial effects of regional and global left ventricular (LV) ischemia induced by left circumflex and left main coronary artery occlusion (CAO), respectively, on indexes of systolic and diastolic LV function in conscious dogs to determine whether diastolic abnormalities precede systolic dysfunction or vice versa during the onset of either regional or global myocardial ischemia. With regional myocardial ischemia, within four beats after left circumflex CAO, there was a significant decrease in end-systolic wall thickness in the ischemic zone followed by significantly enhanced posts

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9

Abramov, A. A., V. L. Lakomkin, A. V. Prosvirnin та V. I. Kapelko. "Pressure and Volume Characteristics of the Left Ventriclе in Its Diastolic and Systolic Dysfunction". Kardiologiia 59, № 4 (2019): 45–51. http://dx.doi.org/10.18087/cardio.2019.4.2647.

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The Aimof the study was a detailed investigation of pressure volume-loop (PV-loop) curves in the rat heart during development of doxorubicin cardiomyopathy.Materials and methods. Cardiomyopathy in rats has been developed after 4 weeks doxorubicin administration (2 mg / kg weekly).Results. Echocardiographic study of rats in 8 weeks from onset of doxorubicin administration showed preponderance of systolic dysfunction (67 %) with decrease of left ventricular (LV) ejection fraction (EF) by 30 %. Simultaneous registration of LV pressure and volume showed that diastolic LV volume was preserved in do

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10

Renna, Brian F., Scott M. MacDonnell, Patricia O. Reger, Deborah L. Crabbe, Steven R. Houser, and Joseph R. Libonati. "Relative systolic dysfunction in female spontaneously hypertensive rat myocardium." Journal of Applied Physiology 103, no. 1 (2007): 353–58. http://dx.doi.org/10.1152/japplphysiol.01416.2006.

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Hypertension and exercise independently induce left ventricular (LV) remodeling and alter LV function. The purpose of this study was to determine systolic and diastolic LV pressure-volume relationships (LV-PV) in spontaneously hypertensive rats (SHR) with and without LV hypertrophy, and to determine whether 6 mo of exercise training modified the LV-PV in SHR. Four-month-old female SHR ( n = 20), were assigned to a sedentary (SHR-SED) or treadmill-trained (SHR-TRD) group (∼60% peak O2 consumption, 5 days/wk, 6 mo), while age-matched female Wistar-Kyoto rats (WKY; n = 13) served as normotensive

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11

Tveita, Torkjel, Kirsti Ytrehus, Eivind S. P. Myhre, and Olav Hevrøy. "Left ventricular dysfunction following rewarming from experimental hypothermia." Journal of Applied Physiology 85, no. 6 (1998): 2135–39. http://dx.doi.org/10.1152/jappl.1998.85.6.2135.

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This study was aimed at elucidating whether ventricular hypothermia-induced dysfunction persisting after rewarming the unsupported in situ dog heart could be characterized as a systolic, diastolic, or combined disturbance. Core temperature of 8 mongrel dogs was gradually lowered to 25°C and returned to 37°C over a period of 328 min. Systolic function was described by maximum rate of increase in left ventricular (LV) pressure (dP/d tmax), relative segment shortening (SS%), stroke volume (SV), and the load-independent contractility index, preload recruitable stroke work (PRSW). Diastolic functio

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Szekely, Yishay, Yael Lichter, Philippe Taieb, et al. "Spectrum of Cardiac Manifestations in COVID-19." Circulation 142, no. 4 (2020): 342–53. http://dx.doi.org/10.1161/circulationaha.120.047971.

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Background: Information on the cardiac manifestations of coronavirus disease 2019 (COVID-19) is scarce. We performed a systematic and comprehensive echocardiographic evaluation of consecutive patients hospitalized with COVID-19 infection. Methods: One hundred consecutive patients diagnosed with COVID-19 infection underwent complete echocardiographic evaluation within 24 hours of admission and were compared with reference values. Echocardiographic studies included left ventricular (LV) systolic and diastolic function and valve hemodynamics and right ventricular (RV) assessment, as well as lung

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13

Roy, Rajesh, Bhagirath Solanki, Niraj Chawda, et al. "Cardiac function’s in patients with chronic kidney disease." International Journal of Advances in Medicine 10, no. 1 (2022): 59. http://dx.doi.org/10.18203/2349-3933.ijam20223402.

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Background: To assess the cardiac functions in patients with chronic kidney disease (CKD).Methods: 150 patients with CKD were randomly selected. 12 lead ECG were performed to detect CVD. All Patients were diagnosed with CKD. The left ventricular ejection fraction (LVEF) and fractional shortening (FS) were taken as measures of LV systolic function. Diastolic function was determined by measuring early to late peak velocities (E/A) ratio by spectral Doppler LV inflow velocity. Results: Male: female 95 and 55, hypertension 67% was leading cause of CKD. Diastolic dysfunction as denoted by E/A ratio

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14

Londono-Hoyos, Francisco, Patrick Segers, Zeba Hashmath, et al. "Non-invasive intraventricular pressure differences estimated with cardiac MRI in subjects without heart failure and with heart failure with reduced and preserved ejection fraction." Open Heart 6, no. 2 (2019): e001088. http://dx.doi.org/10.1136/openhrt-2019-001088.

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ObjectiveNon-invasive assessment of left ventricular (LV) diastolic and systolic function is important to better understand physiological abnormalities in heart failure (HF). The spatiotemporal pattern of LV blood flow velocities during systole and diastole can be used to estimate intraventricular pressure differences (IVPDs). We aimed to demonstrate the feasibility of an MRI-based method to calculate systolic and diastolic IVPDs in subjects without heart failure (No-HF), and with HF with reduced ejection fraction (HFrEF) and HF with preserved ejection fraction (HFpEF).MethodsWe studied 159 su

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15

Arramraju, Sreenivas Kumar, Rama Krishna Janapati, Sudhakar Reddy Pathakota, Sanjeeva Kumar E, and Gokul Reddy Mandala. "Reversible LV Dysfunction After TAVR." Indian Journal of Clinical Cardiology 1, no. 1 (2020): 17–19. http://dx.doi.org/10.1177/2632463619899567.

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Aortic stenosis (AS) is characterized by gradual thickening, fibrosis, and calcification leading to reduced opening of aortic valve leaflets. Aortic valve narrowing increases the afterload on left ventricle (LV), which consequently leads to hypertrophy and myocardial fibrosis which over a period of time leads to diastolic dysfunction. LV diastolic dysfunction is an independent predictor of heart failure rehospitalization and mortality in post-aortic valve replacement patients. Chronic pressure overload leads to development of systolic dysfunction due to afterload mismatch. Patients with severe

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Pereira, Alberto M., Victoria Delgado, Johannes A. Romijn, Johannes W. A. Smit, Jeroen J. Bax, and Richard A. Feelders. "Cardiac dysfunction is reversed upon successful treatment of Cushing's syndrome." European Journal of Endocrinology 162, no. 2 (2010): 331–40. http://dx.doi.org/10.1530/eje-09-0621.

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ObjectiveIn patients with active Cushing's syndrome (CS), cardiac structural and functional changes have been described in a limited number of patients. It is unknown whether these changes reverse after successful treatment. We therefore evaluated the changes in cardiac structure and dysfunction after successful treatment of CS, using more sensitive echocardiographic parameters (based on two-dimensional strain imaging) to detect subtle changes in cardiac structure and function.MethodsIn a prospective study design, we studied 15 consecutive CS patients and 30 controls (matched for age, sex, bod

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Gamrat, Aleksandra, Michał A. Surdacki, Bernadeta Chyrchel, and Andrzej Surdacki. "Endothelial Dysfunction: A Contributor to Adverse Cardiovascular Remodeling and Heart Failure Development in Type 2 Diabetes beyond Accelerated Atherogenesis." Journal of Clinical Medicine 9, no. 7 (2020): 2090. http://dx.doi.org/10.3390/jcm9072090.

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Endothelial dysfunction, associated with depressed nitric oxide (NO) bioavailability, is a well-recognized contributor to both accelerated atherogenesis and microvascular complications in type 2 diabetes (DM). However, growing evidence points to the comorbidities-driven endothelial dysfunction within coronary microvessels as a key player responsible for left ventricular (LV) diastolic dysfunction, restrictive LV remodeling and heart failure with preserved ejection fraction (HFpEF), the most common form of heart failure in DM. In this review we have described: (1) multiple cellular pathways whi

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Nikolaeva, Galina N., Anna B. Sugak, Elena V. Feoktistova, and Il'ya O. Kurov. "Echocardiographic assessment of the state of the heart in children with ß-thalassemia." Pediatric Hematology/Oncology and Immunopathology 15, no. 3 (2016): 23–28. https://doi.org/10.24287/1726-1708-2016-15-3-23-28.

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The main causes of the development of thalassemia-associated cardiomyopathy are volume overload of the heart resulting from adaptation to chronic anaemia and iron toxic effects on the myocardium resulting from replacement blood transfusion therapy. In order to reveal left ventricle (LV) dysfunction echocardiography (Echo-CG) with examination of the mitral valve fibrous ring (MV FR) motion was performed in the tissue Doppler mode in 50 patients with ß-thalassemia and 47 conditionally healthy children aged 2 to 16 years. Patients with ß-thalassemia as compared with the control group had a signif

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Wong, James, Radomir Chabiniok, Adelaide deVecchi, et al. "Age-related changes in intraventricular kinetic energy: a physiological or pathological adaptation?" American Journal of Physiology-Heart and Circulatory Physiology 310, no. 6 (2016): H747—H755. http://dx.doi.org/10.1152/ajpheart.00075.2015.

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Aging has important deleterious effects on the cardiovascular system. We sought to compare intraventricular kinetic energy (KE) in healthy subjects of varying ages with subjects with ventricular dysfunction to understand if changes in energetic momentum may predispose individuals to heart failure. Four-dimensional flow MRI was acquired in 35 healthy subjects (age: 1–67 yr) and 10 patients with left ventricular (LV) dysfunction (age: 28–79 yr). Healthy subjects were divided into age quartiles (1st quartile: <16 yr, 2nd quartile: 17–32 yr, 3rd quartile: 33–48 yr, and 4th quartile: 49–64 yr).

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Gelpi, Ricardo J., Shumin Gao, Peiyong Zhai, et al. "Genetic inhibition of calcineurin induces diastolic dysfunction in mice with chronic pressure overload." American Journal of Physiology-Heart and Circulatory Physiology 297, no. 5 (2009): H1814—H1819. http://dx.doi.org/10.1152/ajpheart.00449.2009.

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Calcineurin is a Ca2+/calmodulin-dependent protein phosphatase that induces myocardial growth in response to several physiological and pathological stimuli. Calcineurin inhibition, induced either via cyclosporine or genetically, can decrease myocardial hypertrophy secondary to pressure overload without affecting left ventricular (LV) systolic function. Since hypertrophy can also affect LV diastolic function, the goal of this study was to examine the effects of chronic pressure overload (2 wk aortic banding) in transgenic (Tg) mice overexpressing Zaki-4β (TgZ), a specific endogenous inhibitor o

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Khaidirman, Sophia Khairina, Zulfikri Mukhtar, Yuke Sarastri, Andre Pasha Ketaren, Abdul Halim Raynaldo, and Cut Aryfa Andra. "The Relationship between Pre Discharge Left Ventricle Diastolic Dysfunction and 30 days And 6 Months Rehospitalization in Patients with Heart Failure with Reduced Ejection Fraction (HFrEF) at Haji Adam Malik General Hospital Medan." Journal of Society Medicine 2, no. 5 (2023): 148–54. https://doi.org/10.47353/jsocmed.v2i5.33.

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Introduction: Heart failure (HF) is a complex clinal manifestation that cause abnormality of structural and/or functional of the heart. HF is due to diastolic dysfunction and systolic dysfunction of the left ventricle (LV). The aim of this study is to assess the relationship between grading of pre-discharge LV diastolic dysfunction and readmission at 30 days post discharge and 6 months post discharge. Method: This is a cohort retrospective study in HFrEF patients which are treated at Pusat Jantung Terpadu RSUP H. Adam Malik Medan on January 2021 until December 2021. Pre discharge echocardiogra

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Besnier, Marie, David Coquerel, Julie Favre, et al. "Protein tyrosine phosphatase 1B inactivation limits aging-associated heart failure in mice." American Journal of Physiology-Heart and Circulatory Physiology 314, no. 6 (2018): H1279—H1288. http://dx.doi.org/10.1152/ajpheart.00049.2017.

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We have previously shown that protein tyrosine phosphatase 1B (PTP1B) inactivation in mice [PTP1B-deficient (PTP1B−/−) mice] improves left ventricular (LV) angiogenesis, perfusion, remodeling, and function and limits endothelial dysfunction after myocardial infarction. However, whether PTP1B inactivation slows aging-associated cardiovascular dysfunction remains unknown. Wild-type (WT) and PTP1B−/− mice were allowed to age until 18 mo. Compared with old WT mice, in which aging increased the LV mRNA expression of PTP1B, old PTP1B−/− mice had 1) reduced cardiac hypertrophy with decreased LV mRNA

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Mizarienė, Vaida, Silvija Bučytė, Diana Žaliaduonytė-Pekšienė, et al. "Components of Left Ventricular Ejection and Filling in Patients With Aortic Regurgitation Assessed by Speckle-Tracking Echocardiography." Medicina 48, no. 1 (2012): 5. http://dx.doi.org/10.3390/medicina48010005.

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The aim of our study was to evaluate left ventricular (LV) longitudinal, radial, and rotational function and its relationship with conventional LV parameters of systolic and diastolic function in patients with aortic regurgitation (AR) by speckle-tracking echocardiography. Material and Methods. A total of 26 asymptomatic patients with moderate AR, 34 patients with severe AR, and 28 healthy controls were included into the study. LV rotation and longitudinal and radial strain were measured offline using speckle-tracking imaging. Results. The systolic longitudinal strain (–18.3% [SD, 2.18%] vs. –

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Baka, Tomas, Julius Hodosy, Kristina Krajcirovicova та ін. "17β-Estradiol treatment reversed left ventricular dysfunction in castrated male rats: an echocardiographic study". Canadian Journal of Physiology and Pharmacology 96, № 8 (2018): 850–54. http://dx.doi.org/10.1139/cjpp-2017-0596.

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No data are available on heart function in chronic testosterone deficiency and on the effect of estrogen treatment. Eighteen 4-week-old male Lewis rats were randomly divided into 3 groups (n = 6): 1 group of sham-operated rats and 2 groups of castrated rats. Sixty-six weeks after surgery, 1 castrated group received a dose of 17β-estradiol (10 μg/kg per day) and the remaining 2 groups received a placebo subcutaneously for 14 days. Left ventricular (LV) systolic and diastolic functions were measured by transthoracic echocardiography. Castration decreased LV ejection fraction (9%) and fractional

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Hoit, B. D., Y. Shao, M. Gabel, C. Pawloski-Dahm, and R. A. Walsh. "Left atrial systolic and diastolic function after cessation of pacing in tachycardia-induced heart failure." American Journal of Physiology-Heart and Circulatory Physiology 273, no. 2 (1997): H921—H927. http://dx.doi.org/10.1152/ajpheart.1997.273.2.h921.

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Studies in the rapid-pacing model of heart failure have shown that left ventricular (LV) systolic function normalizes on cessation of pacing and LV diastolic dysfunction persists, but there is no information regarding atrial function under these conditions. To determine the effects of cessation of pacing on left atrial (LA) systolic and diastolic function, ten dogs with rapid pacing-induced heart failure (250 beats/min for 3-4 wk), six dogs with regression of heart failure (4 wk after cessation of rapid pacing), and seven control dogs were instrumented with LA sonomicrometers and micromanomete

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Shree, C. Mamatha, K. S. Prashanth, and B. Girija. "An echocardiographic study of the effect of obesity on systolic and diastolic functions of the left ventricle in hypertensive adults." Indian Journal of Physiology and Pharmacology 65 (February 25, 2022): 237–41. http://dx.doi.org/10.25259/ijpp_169_2021.

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Objectives: The objectives of the study were to examine the effect of obesity on echocardiographic parameters of systolic and diastolic functions of the left ventricle (LV) in asymptomatic hypertensive adults. Materials and Methods: A cross-sectional study was conducted with 100 individuals (65 males and 35 females). Their blood pressure and body mass index were recorded following which they were divided into obese hypertensives and non-obese hypertensives. Echocardiographic examination was done, and parameters indicating LV geometry and function were recorded. Data were statistically analysed

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Zherko, O. M., and E. I. Shkrebneva. "2D Speckle Tracking echocardiography in the prognostication of left ventricle diastolic dysfunction." Medical Visualization 24, no. 3 (2020): 76–87. http://dx.doi.org/10.24835/1607-0763-2020-3-76-87.

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The aim of the study: to develop prediction comprehensive criteria for the diastolic dysfunction (DD) of the left ventricle (LV) according to 2D Speckle Tracking echocardiography (STE).Materials and methods. A clinical and instrumental study of 91 patients aged 64.0 was performed [58.0; 70.0] years in the Minsk Scientific and Practical Center of Surgery, Transplantology and Hematology in 2019. Criteria for inclusion: sinus rhythm, essential arterial hypertension, chronic coronary artery disease, previous left myocardial infarction, after which at least six months have passed to stabilize the L

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Chursina, T. Ya, A. M. Kravchenko, and K. O. Mikhaliev. "LEFT VENTRICULAR REMODELING IN HEART FAILURE (PART I): CURRENT UNDERSTANDING OF PATHOMECHANISMS AND RELATED MYOCARDIAL DYSFUNCTION." Клінічна та профілактична медицина 3, no. 21 (2022): 71–83. http://dx.doi.org/10.31612/2616-4868.3(21).2022.11.

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Aim: to provide a literature review of the current data on various pathomechanisms of left ventricular (LV) remodeling in heart failure (HF) patients and their role in the development and progression of myocardial dysfunction. This paper is a first part of the review, devoted to the current state of pathophysiology of LV remodeling in HF. Material and methods. The thematic scientific papers, published during the last decade, constituted the study material. The research methodology involved bibliosemantic method and structural and logical analysis. Results and discussion. LV remodel

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Panda, Dr Sibaram, and Dr Sunil Kumar Sharma. "Cardiac evaluation of Covid-19 patients with post-discharge dyspnoea." International Journal of Medical Research & Review 8, no. 6 (2020): 432–37. http://dx.doi.org/10.17511/ijmrr.2020.i06.11.

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Background: Dyspnoea is one of the common symptoms in COVID-19 patients after discharge fromthe hospital. So evaluation of cardiac function becomes necessary in COVID patients after hospitaldischarge. AIM: To study the cardiac function of COVID 19 patients presenting with dyspnoea afterdischarge from hospital within 3 months of symptom onset. Materials and methods: 245 post-hospital discharge COVID-19 patients enrolled in the study. The patients with abnormalechocardiography are further divided into three groups, A) patients with PAH±RVD, B) patients withLV diastolic dysfunction C) patients wi

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Sofija, Popevska. "Shorten τ<sub>1</sub> in Chronic Early vs. Late Systolic LV Load for Systolic Dysfunction in Ascending vs. Descending Thoracic Aortic Stenosis". International Journal of Cardiovascular and Thoracic Surgery 10, № 2 (2024): 19–28. http://dx.doi.org/10.11648/j.ijcts.20241002.12.

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&lt;i&gt;Background:&lt;/i&gt; Arterial hypertension (HTA) results with diastolic LV dysfunction (DD), important to develop systolic LV dysfunction and exercise intolerance with HF. Separating between chronic late (LL) to early LV load (EL) during systole, impaired LV relaxation is present earlier in chronic LL vs. EL, having early HF, as result of myocardial ischemia and systolic LV dysfunction in HTA. &lt;i&gt;Objective and Methods:&lt;/i&gt; to assess early systolic in diastolic LV dysfunction from biexponential τ regression assessment, using single beat and

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Dupont, S., J. Maizel, R. Mentaverri, et al. "The onset of left ventricular diastolic dysfunction in SHR rats is not related to hypertrophy or hypertension." American Journal of Physiology-Heart and Circulatory Physiology 302, no. 7 (2012): H1524—H1532. http://dx.doi.org/10.1152/ajpheart.00955.2010.

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Left ventricular (LV) diastolic dysfunction, particularly relaxation abnormalities, are known to be associated with the development of LV hypertrophy (LVH). Preliminary human and animal studies suggested that early LV diastolic dysfunction may be revealed independently of LVH. However, whether LV diastolic dysfunction is compromised before the onset of hypertension and LVH remains unknown. We therefore evaluated LV diastolic function in spontaneously hypertensive rats (SHR) at different ages and tested whether LV diastolic dysfunction is associated with abnormal intracellular calcium homeostas

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Olsson, M. Charlotte, Bradley M. Palmer, Leslie A. Leinwand, and Russell L. Moore. "Gender and aging in a transgenic mouse model of hypertrophic cardiomyopathy." American Journal of Physiology-Heart and Circulatory Physiology 280, no. 3 (2001): H1136—H1144. http://dx.doi.org/10.1152/ajpheart.2001.280.3.h1136.

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Mutations in the cardiac myosin heavy chain (MHC) can cause familial hypertrophic cardiomyopathy (FHC). A transgenic mouse model has been developed in which a missense (R403Q) allele and an actin-binding deletion in the α-MHC are expressed in the heart. We used an isovolumic left heart preparation to study the contractile characteristics of hearts from transgenic (TG) mice and their wild-type (WT) littermates. Both male and female TG mice developed left ventricular (LV) hypertrophy at 4 mo of age. LV hypertrophy was accompanied by LV diastolic dysfunction, but LV systolic function was normal a

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Lakomkin, V. L., A. A. Abramov, E. V. Lukoshkova, A. V. Prosvirnin, and V. I. Kapelko. "HEMODYNAMICS AND CARDIAC CONTRACTILE FUNCTION IN TYPE 1 DIABETES." Kardiologiia 62, no. 8 (2022): 33–37. http://dx.doi.org/10.18087/cardio.2022.8.n1967.

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The cardiohemodynamics was studied 1 week after the administration of streptozotocin (60 mg / kg) or 2 weeks after a dose of 30 mg / kg. All rats had a significantly elevated level of glucose in the blood (up to 27—31 mM). In an echocardiographic study, about 1/3 of diabetic animals exhibited systolic dysfunction, and the remaining 2/3 — diastolic dysfunction with an increase in isovolumic relaxation time by 1.5 times. The catheterization of the left ventricle (LV) with a sensor that allows simultaneous measuring LV pressure and volume in both groups revealed decreased cardiac output by 25—31%

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Iliuță, Luminița, Andreea Gabriella Andronesi, Alexandru Scafa-Udriște, et al. "Incidence and Risk Factors for Long-Term Persistence of Diastolic Dysfunction after Aortic Valve Replacement for Aortic Stenosis Compared with Aortic Regurgitation." Journal of Cardiovascular Development and Disease 10, no. 3 (2023): 131. http://dx.doi.org/10.3390/jcdd10030131.

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(1) Background: Severe left ventricular (LV) diastolic dysfunction with a restrictive diastolic pattern (LVDFP) is generally associated with a worse prognosis. Its evolution and reversibility in the short- and medium-term after aortic valve replacement (AVR) has been little-studied. We aimed to evaluate the evolution of LV remodeling and LV systolic and diastolic function after AVR in aortic stenosis (AS) patients compared to aortic regurgitation (AR). Moreover, we tried to identify the main predictive parameters for postoperative evolution (cardiovascular hospitalization or death and quality

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Shvets, D. A., and S. V. Povetkin. "Limitations of Diagnosis of Ischemic Left Ventricular Dysfunction Using the Values of Strain, Twist and Untwist in Patients With Myocardial Infarction of Various Localization." Kardiologiia 64, no. 3 (2024): 55–62. http://dx.doi.org/10.18087/cardio.2024.3.n2253.

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Aim. To compare capabilities for diagnosing regional and global myocardial dysfunction using the values of longitudinal and circular strain, left ventricular (LV) torsion and untwisting in patients with myocardial infarction (MI) of various locations.Material and methods. Patients included in the study (n=121) were divided into three groups: patients with unstable angina (n=30), patients with anterior MI (n=45), and patients with inferior MI (n=46). Clinical, laboratory and instrumental test were performed, including echocardiography. For a quantitative analysis of LV contractility, the maximu

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W.M., Sallam, Elkaialy A.A., Gharieb M.A., and Thabet S.S. "Prevalence of left ventricular diastolic dysfunction by tissue doppler imaging in patients with end stage renal disease undergoing regular dialysis with preserved systolic function." CARDIOMETRY, no. 33 (November 25, 2024): 87–94. http://dx.doi.org/10.18137/cardiometry.2024.33.8794.

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Background: Patients with end-stage renal disease (ESRD) undergoing regular dialysis face a heightened risk of cardiovascular complications, with left ventricular (LV) diastolic dysfunction being a significant concern. Despite preserved systolic function, diastolic dysfunction can lead to notable morbidity. Tissue Doppler imaging (TDI) is a reliable noninvasive tool for assessing diastolic function. This study aims to investigate the prevalence and severity of LV diastolic dysfunction in ESRD patients undergoing regular dialysis with preserved systolic function. Methods: A cohort of 100 ESRD p

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van Wijngaarden, Suzanne E., Samira Ben Said-Bouyeri, Maarten K. Ninaber, et al. "Progression of Left Ventricular Myocardial Dysfunction in Systemic Sclerosis: A Speckle-tracking Strain Echocardiography Study." Journal of Rheumatology 46, no. 4 (2019): 405–15. http://dx.doi.org/10.3899/jrheum.171207.

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Objective.Cardiac involvement is a main cause of mortality in systemic sclerosis (SSc). Its detection remains challenging using conventional echocardiography and little is known about its potential progression. This study assessed changes in cardiac performance over time in a prospective cohort of patients with SSc, including echocardiographic speckle-tracking strain analysis.Methods.The study included 234 patients with SSc [196 women, age 52 ± 14 yrs, 165 limited SSc, time since diagnosis 5.2 yrs, interquartile range (IQR) 2.9–11.3]. Clinical variables, laboratory tests, pulmonary function te

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Suzuki, M., C. P. Cheng, N. Ohte, and W. C. Little. "Left ventricular spherical dilation and regional contractile dysfunction in dogs with heart failure." American Journal of Physiology-Heart and Circulatory Physiology 273, no. 3 (1997): H1058—H1067. http://dx.doi.org/10.1152/ajpheart.1997.273.3.h1058.

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Left ventricular (LV) short- and long-axis contractile function and LV structural changes were serially measured in eight instrumented dogs during the development of congestive heart failure (CHF) induced by rapid right ventricular (RV) pacing. After 10 days of pacing, LV end-diastolic volume (VED) had not increased; however, the slope of LV end-systolic pressure-volume relation had decreased from 7.4 +/- 2.6 to 4.9 +/- 1.1 mmHg/ml (P < 0.05), and the slope of LV stroke work-VED relation had fallen from 78.4 +/- 9.1 to 64.2 +/- 7.2 mmHg (P < 0.05). The slopes of end-systolic pressure-dim

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Matunovic, Radomir, Zdravko Mijailovic, Dragan Tavciovski, Zoran Cosic, and Zoran Stajic. "Diastolic dysfunction types in the prediction of viable myocardium functional recovery." Vojnosanitetski pregled 65, no. 2 (2008): 113–18. http://dx.doi.org/10.2298/vsp0802113m.

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Background/Aim. It is well known that patients with coronary artery disease and viable tissue as a guarantee of contractile recovery (CR), despite of decreasing ejection fraction (EF) and systolic dysfunction, could have benefit from surgical revascularization. Therefore, relationship between diastolic filling type and early postoperative recovery and complications need to be established. The aim of this study was to investigate the relation between different left ventricular (LV) diastolic filling types and CR in patients after surgical revascularization with differently preserved systolic fu

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Abbas, Ethar Saad, Oday J. Al-Salihi, and Abdulhadi Hameed Alkaaby. "Correlation of Arterial Stiffness with Left Ventricular Global Longitudinal Strain and Diastolic Function in Hypertensive Patients." Medical Journal of Babylon 22, no. 2 (2025): 610–14. https://doi.org/10.4103/mjbl.mjbl_1309_23.

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Abstract Background: Arterial stiffness is one of the complications of hypertension. It is a hallmark of vascular aging, and when assessed with the carotid–femoral-pulse wave velocity (cf-PWV), it is predictive of outcome regardless of blood pressure components. Objectives: To detect subclinical involvement of left ventricular (LV) systolic and diastolic dysfunction in hypertensive patients in whom arterial stiffness is high. Materials and Methods: A case–control study with 55 randomly taken hypertensive patients aged 30–60 years old (female = 25 and male = 30) was conducted from December 2022

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Lu, Xiaozhao, Qiang Li, Jingru Deng, et al. "Renal Insufficiency Increases the Combined Risk of Left Ventricular Hypertrophy and Dysfunction in Patients at High Risk of Cardiovascular Diseases." Journal of Clinical Medicine 12, no. 5 (2023): 1818. http://dx.doi.org/10.3390/jcm12051818.

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Background: The identification of asymptomatic structural and functional cardiac abnormalities can help us to recognize early and intervene in patients at pre-heart failure (HF). However, few studies have adequately evaluated the associations of renal function and left ventricular (LV) structure and function in patients at high risk of cardiovascular diseases (CVD). Methods: Patients undergoing coronary angiography and/or percutaneous coronary interventions were enrolled from the Cardiorenal ImprovemeNt II (CIN-II) cohort study, and their echocardiography and renal function were assessed at ad

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Kim, Hyun-Jin, Myung-A. Kim, Hack-Lyoung Kim, et al. "Effects of multiparity on left ventricular diastolic dysfunction in women: cross-sectional study of the KoRean wOmen’S chest pain rEgistry (KoROSE)." BMJ Open 8, no. 12 (2018): e026968. http://dx.doi.org/10.1136/bmjopen-2018-026968.

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ObjectivesTo investigate the association between left ventricular (LV) diastolic dysfunction and multiparity in patients with suspected coronary artery disease (CAD).DesignCross-sectional study.SettingLinked secondary and tertiary care records from 29 cardiac centres which participated in KoRean wOmen’S chest pain rEgistry.Participants960 women with suspected CAD who underwent invasive coronary angiography from February 2011 to May 2017. The patients were classified by parity number, as follows: low-parity, 0 to <3; multiparity, ≥3 pregnancies.Main outcome measurePrevalence of LV diastolic

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Gill, Robert M., Bonita D. Jones, Angela K. Corbly, et al. "Cardiac diastolic dysfunction in conscious dogs with heart failure induced by chronic coronary microembolization." American Journal of Physiology-Heart and Circulatory Physiology 291, no. 6 (2006): H3154—H3158. http://dx.doi.org/10.1152/ajpheart.00052.2006.

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Left ventricular (LV) diastolic dysfunction is a fundamental impairment in congestive heart failure (CHF). This study examined LV diastolic function in the canine model of CHF induced by chronic coronary embolization (CCE). Dogs were implanted with coronary catheters (both left anterior descending and circumflex arteries) for CCE and instrumented for measurement of LV pressure and dimension. Heart failure was elicited by daily intracoronary injections of microspheres (1.2 million, 90- to 120-μm diameter) for 24 ± 4 days, resulting in significant depression of cardiac systolic function. After C

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Zilberman, Mark V., Wei Du, Wanda J. Whitten-Surney, and Sharada A. Sarnaik. "Do Pediatric Sickle Cell Disease Patients Develop Diastolic Dysfunction?." Blood 106, no. 11 (2005): 3195. http://dx.doi.org/10.1182/blood.v106.11.3195.3195.

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Abstract Sickle cell disease (SCD) is a known cause of chronic volume overload. Although systolic dysfunction is rare, as many as 80% of adult patients with SCD have an echocardiographic mitral valve inflow pattern suggestive of abnormal left ventricular (LV) diastolic function (DF). DF has not been studied in pediatric SCD patients. Therefore, the objective of this study was to evaluate DF in pediatric SCD patients using echocardiographic velocities of mitral inflow and tissue Doppler (TDI) indices. Echocardiograms were performed in 79 SCD patients (ages 2 – 18 years), and 84 controls matched

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Khaidirman, Sophia K., Harris Hasan, Cut A. Andra, Hilfan AP Lubis, Amos Dangana, and T. Bob Haykal. "Relationship of left ventricular diastolic dysfunction with quality of life in heart failure patients with reduced ejection fraction (HFrEF)." Narra J 4, no. 2 (2024): e707. http://dx.doi.org/10.52225/narra.v4i2.707.

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Heart failure is a complex clinical manifestation due to diastolic dysfunction and systolic dysfunction of the left ventricle (LV). Diastolic dysfunction of the LV plays an important role in worsening the quality of life (QoL) in heart failure patients. The aim of this study was to assess the relationship between the severity or grade of LV diastolic dysfunction and QoL in heart failure with reduced ejection fraction (HFrEF) patients. A retrospective cohort study was conducted at the Cardiac Center of H. Adam Malik Hospital, Medan, Indonesia, from January 2022 to December 2022. This study incl

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ZHONG, LIANG, DHANJOO N. GHISTA, E. Y. K. NG, SOO TEIK LIM, and SIANG JIN CHUA. "MEASURES AND INDICES FOR INTRINSIC CHARACTERIZATION OF CARDIAC DYSFUNCTION DURING FILLING AND SYSTOLIC EJECTION." Journal of Mechanics in Medicine and Biology 05, no. 02 (2005): 307–32. http://dx.doi.org/10.1142/s0219519405001369.

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The paper discusses the development and application of bioengineering indices for reliable diagnosis of cardiac functional modalities in filling and contraction phases. During diastolic filling, the left-ventricular (LV) volume developed is a response to left-atrium (LV) suction at early rapid filling and LA contraction at late filling. However, in LV ejection, the LV flow-rate and aortic pressure constitute response to LV myocardial stress and intra-LV pressure generation. The differential equations used in the governing of these relationships have been developed. By matching the solutions of

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Flu, Willem-Jan, Jan-Peter van Kuijk, Sanne E. Hoeks, et al. "Prognostic Implications of Asymptomatic Left Ventricular Dysfunction in Patients Undergoing Vascular Surgery." Anesthesiology 112, no. 6 (2010): 1316–24. http://dx.doi.org/10.1097/aln.0b013e3181da89ca.

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Background The prognostic value of heart failure symptoms on postoperative outcome is well acknowledged in perioperative guidelines. The prognostic value of asymptomatic left ventricular (LV) dysfunction remains unknown. This study evaluated the prognostic implications of asymptomatic LV dysfunction in vascular surgery patients assessed with routine echocardiography. Methods Echocardiography was performed preoperatively in 1,005 consecutive vascular surgery patients. Systolic LV dysfunction was defined as LV ejection fraction less than 50%. Ratio of mitral-peak velocity during early and late f

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Osadchii, Oleg E., Gavin R. Norton, Richard McKechnie, Dawn Deftereos та Angela J. Woodiwiss. "Cardiac dilatation and pump dysfunction without intrinsic myocardial systolic failure following chronic β-adrenoreceptor activation". American Journal of Physiology-Heart and Circulatory Physiology 292, № 4 (2007): H1898—H1905. http://dx.doi.org/10.1152/ajpheart.00740.2006.

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There is no direct evidence to indicate that pump dysfunction in a dilated chamber reflects the impact of chamber dilatation rather than the degree of intrinsic systolic failure resulting from myocardial damage. In the present study, we explored the relative roles of intrinsic myocardial systolic dysfunction and chamber dilatation as mediators of left ventricular (LV) pump dysfunction. Administration of isoproterenol, a β-adrenoreceptor agonist, for 3 mo to rats (0.1 mg·kg−1·day−1) resulted in LV pump dysfunction as evidenced by a reduced LV endocardial fractional shortening (echocardiography)

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Miyamoto, M., D. E. McClure, E. R. Schertel, et al. "Effects of hypoproteinemia-induced myocardial edema on left ventricular function." American Journal of Physiology-Heart and Circulatory Physiology 274, no. 3 (1998): H937—H944. http://dx.doi.org/10.1152/ajpheart.1998.274.3.h937.

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In previous studies, we observed left ventricular (LV) systolic and diastolic dysfunction in association with interstitial myocardial edema (IME) induced by either coronary venous hypertension (CVH) or lymphatic obstruction. In the present study, we examined the effects of myocardial edema induced by acute hypoproteinemia (HP) on LV systolic and diastolic function. We also combined the methods of HP and CVH (HP-CVH) to determine their combined effects on LV function and myocardial water content (MWC). We used a cell-saving device to lower plasma protein concentration in HP and HP-CVH groups. C

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Hayashida, Wataru, Julian Donckier, Henri Van Mechelen, André A. Charlier, and Hubert Pouleur. "Load-sensitive diastolic relaxation in hypertrophied left ventricles." American Journal of Physiology-Heart and Circulatory Physiology 274, no. 2 (1998): H609—H615. http://dx.doi.org/10.1152/ajpheart.1998.274.2.h609.

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We studied effects of enalaprilat and L-158,809, an angiotensin II type-1 receptor antagonist, on left ventricular (LV) diastolic relaxation in 11 normal control dogs and 16 LV hypertrophied (LVH) dogs with perinephritic hypertension. At baseline, LV systolic and end-diastolic pressures and end-systolic elastance were increased in the LVH group (all P < 0.01 vs. the control group). LV relaxation time constant was also prolonged ( P < 0.01), suggesting impaired LV diastolic relaxation in this model of LVH. Before and after the administration of enalaprilat (0.25 mg/kg) and L-158,809 (0.30

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