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Journal articles on the topic 'LV systolic dysfunction'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Rao, Tarun, Mohit Karwa, and Anil Wanjari. "Left ventricular dysfunction among chronic kidney disease patients: a cross sectional study." International Journal of Advances in Medicine 5, no. 5 (2018): 1093. http://dx.doi.org/10.18203/2349-3933.ijam20183390.

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Background: There is a significant worldwide burden of CKD; which is likely to increase further. Cardiovascular diseases constitute major cause of morbidity and mortality in CKD. LV dysfunction may be present despite the asymptomatic phase during the early stages of CKD. Thus, early detection of LV dysfunction and targeted interventions can improve prognosis in CKD.Methods: This cross-sectional study was conducted among 250 CKD admitted patients. Echocardiographic examination was done to determine the systolic and diastolic function of LV. For LV systolic function ejection fraction and % fract

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Kusumoto, Go, Kenji Shigematsu, Kouhei Iwashita, Kenji Tominaga, Takaaki Totoki, and Ken Yamaura. "Association between Preoperative Cardiac Left Ventricular Dysfunction and Perioperative Intraaortic Balloon Pump in Patients Undergoing Off-Pump Coronary Artery Bypass Surgery." Heart Surgery Forum 20, no. 4 (2017): 147. http://dx.doi.org/10.1532/hsf.1808.

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Background: Prophylactic use of intraaortic balloon pump (IABP) reduces hospital mortality in patients with left ventricular (LV) systolic dysfunction undergoing coronary artery bypass surgery (CABG); however, its association in patients with LV diastolic dysfunction is unclear. This retrospective study investigated the association between preoperative LV function and perioperative use of IABP in patients undergoing off-pump CABG (OPCAB) at a university hospital.Methods: 100 consecutive patients who underwent OPCAB between January 1, 2011 and August 31, 2014 were studied. Preoperative LV funct

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3

Young, James B. "Asymptomatic LV systolic dysfunction was more than twice as prevalent as symptomatic LV systolic dysfunction." Evidence-based Cardiovascular Medicine 2, no. 1 (1998): 29. http://dx.doi.org/10.1016/s1361-2611(98)80026-2.

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Dillier, Roger, Richard Kobza, Susanne Erne, Michel Zuber, Patricia Arand, and Paul Erne. "Noninvasive Detection of Left-Ventricular Systolic Dysfunction by Acoustic Cardiography in Atrial Fibrillation." Cardiology Research and Practice 2011 (2011): 1–7. http://dx.doi.org/10.4061/2011/173102.

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Objectives. Assessment of left ventricular (LV) systolic function in patients with atrial fibrillation can be difficult. Acoustic cardiography provides several parameters for quantifying LV systolic function. We evaluated the ability of acoustic cardiography to detect LV systolic dysfunction in patients with and without atrial fibrillation.Design. We studied 194 patients who underwent acoustic cardiography and cardiac catheterization including measurement of angiographic ejection fraction (EF) and maximum LV dP/dt. LV systolic dysfunction was defined as LV maximum dP/dt<1600 mmHg/s. Acousti

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Ihara, T., K. Komamura, Y. T. Shen, et al. "Left ventricular systolic dysfunction precedes diastolic dysfunction during myocardial ischemia in conscious dogs." American Journal of Physiology-Heart and Circulatory Physiology 267, no. 1 (1994): H333—H343. http://dx.doi.org/10.1152/ajpheart.1994.267.1.h333.

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We studied the initial effects of regional and global left ventricular (LV) ischemia induced by left circumflex and left main coronary artery occlusion (CAO), respectively, on indexes of systolic and diastolic LV function in conscious dogs to determine whether diastolic abnormalities precede systolic dysfunction or vice versa during the onset of either regional or global myocardial ischemia. With regional myocardial ischemia, within four beats after left circumflex CAO, there was a significant decrease in end-systolic wall thickness in the ischemic zone followed by significantly enhanced posts

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Mamatha, Shree C., KS Prashanth, and B. Girija. "Effect of obesity and hypertension on left ventricular geometry and function among asymptomatic Indian adults." Bioinformation 20, no. 8 (2024): 862–67. http://dx.doi.org/10.6026/973206300200862.

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Hypertension & obesity are important independent predictors of cardiovascular morbidity & mortality specifically left ventricular (LV) functions. With the Objectives to examine the effect of obesity & hypertension on echocardiographic parameters of geometry, systolic, and diastolic functions of left ventricle in asymptomatic adults the cross-sectional study was conducted with 100 individuals (60 male & 40 female). Their Blood Pressure & Body Mass Index was recorded following which they were divided into obese normotensives & non-obese hypertensive. Echocardiographic par

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Choi, Sun Ryoung, Young-Ki Lee, Hayne Cho Park, et al. "Clinical significance of central systolic blood pressure in LV diastolic dysfunction and CV mortality." PLOS ONE 16, no. 5 (2021): e0250653. http://dx.doi.org/10.1371/journal.pone.0250653.

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Background and aims Cardiovascular (CV) disease is the major cause of death in patients with end-stage kidney disease (ESKD). Left ventricular (LV) diastolic dysfunction reflects LV pressure overload and is common in patients with ESKD. Recently, there have been studies on the usefulness of central blood pressure (BP); however, the relationship between central BP and LV diastolic dysfunction is not clear in dialysis patients with preserved systolic function. The purpose of this study was to investigate the clinical implication of central BP on LV diastolic dysfunction and CV mortality in the E

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Ballo, Piercarlo, Irene Betti, Giuseppe Mangialavori, Leandro Chiodi, Gherardo Rapisardi, and Alfredo Zuppiroli. "Peripartum Cardiomyopathy Presenting with Predominant Left Ventricular Diastolic Dysfunction: Efficacy of Bromocriptine." Case Reports in Medicine 2012 (2012): 1–6. http://dx.doi.org/10.1155/2012/476903.

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Management of patients with peripartum cardiomyopathy (PPCM) is still a major clinical problem, as only half of them or slightly more show complete recovery of left ventricular (LV) function despite conventional evidence-based treatment for heart failure. Recent observations suggested that bromocriptine might favor recovery of LV systolic function in patients with PPCM. However, no evidence exists regarding its effect on LV diastolic dysfunction, which is commonly observed in these patients. Tissue Doppler (TD) is an echocardiographic technique that provides unique information on LV diastolic

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Osadchii, Oleg E., Gavin R. Norton, Richard McKechnie, Dawn Deftereos та Angela J. Woodiwiss. "Cardiac dilatation and pump dysfunction without intrinsic myocardial systolic failure following chronic β-adrenoreceptor activation". American Journal of Physiology-Heart and Circulatory Physiology 292, № 4 (2007): H1898—H1905. http://dx.doi.org/10.1152/ajpheart.00740.2006.

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There is no direct evidence to indicate that pump dysfunction in a dilated chamber reflects the impact of chamber dilatation rather than the degree of intrinsic systolic failure resulting from myocardial damage. In the present study, we explored the relative roles of intrinsic myocardial systolic dysfunction and chamber dilatation as mediators of left ventricular (LV) pump dysfunction. Administration of isoproterenol, a β-adrenoreceptor agonist, for 3 mo to rats (0.1 mg·kg−1·day−1) resulted in LV pump dysfunction as evidenced by a reduced LV endocardial fractional shortening (echocardiography)

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&NA;. "Warfarin improves survival in LV systolic dysfunction." Inpharma Weekly &NA;, no. 1137 (1998): 16. http://dx.doi.org/10.2165/00128413-199811370-00027.

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Talat, Sidra, Abdul Malik Sheikh, Hina Sattar, Asma Kanwal, Tauqeer Akbar, and Hissana asghar. "THE TRANSIENT EFFECTS OF TRANS-CATHETER PATENT DUCTUS ARTERIOSUS CLOSURE ON LEFT VENTRICULAR SYSTOLIC FUNCTION." Pakistan Postgraduate Medical Journal 34, no. 02 (2023): 88–92. http://dx.doi.org/10.51642/ppmj.v34i02.576.

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Objectives: This study aims to measure changes in left ventricular systolic function after closure of patent ductus arteriosus and to find out echocardiographic predictors for LV dysfunction. Methods: A prospective study was conducted from July 01, 2021, till June 30, 2022. The study included all patients who experienced percutaneous closure of PDA in this duration. LV function was assessed before and then one day, one month and three months after the transcatheter closure. Patients with preexisting LV dysfunction and significant associated cardiac lesions were excluded from study.

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Renna, Brian F., Scott M. MacDonnell, Patricia O. Reger, Deborah L. Crabbe, Steven R. Houser, and Joseph R. Libonati. "Relative systolic dysfunction in female spontaneously hypertensive rat myocardium." Journal of Applied Physiology 103, no. 1 (2007): 353–58. http://dx.doi.org/10.1152/japplphysiol.01416.2006.

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Hypertension and exercise independently induce left ventricular (LV) remodeling and alter LV function. The purpose of this study was to determine systolic and diastolic LV pressure-volume relationships (LV-PV) in spontaneously hypertensive rats (SHR) with and without LV hypertrophy, and to determine whether 6 mo of exercise training modified the LV-PV in SHR. Four-month-old female SHR ( n = 20), were assigned to a sedentary (SHR-SED) or treadmill-trained (SHR-TRD) group (∼60% peak O2 consumption, 5 days/wk, 6 mo), while age-matched female Wistar-Kyoto rats (WKY; n = 13) served as normotensive

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Sofija, Popevska. "Shorten τ<sub>1</sub> in Chronic Early vs. Late Systolic LV Load for Systolic Dysfunction in Ascending vs. Descending Thoracic Aortic Stenosis". International Journal of Cardiovascular and Thoracic Surgery 10, № 2 (2024): 19–28. http://dx.doi.org/10.11648/j.ijcts.20241002.12.

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&lt;i&gt;Background:&lt;/i&gt; Arterial hypertension (HTA) results with diastolic LV dysfunction (DD), important to develop systolic LV dysfunction and exercise intolerance with HF. Separating between chronic late (LL) to early LV load (EL) during systole, impaired LV relaxation is present earlier in chronic LL vs. EL, having early HF, as result of myocardial ischemia and systolic LV dysfunction in HTA. &lt;i&gt;Objective and Methods:&lt;/i&gt; to assess early systolic in diastolic LV dysfunction from biexponential τ regression assessment, using single beat and

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Meel, Ruchika, Ferande Peters, Bijoy K. Khandheria, Elena Libhaber, and Mohammed Essop. "Atrial-ventricular function in rheumatic mitral regurgitation using strain imaging." Echo Research and Practice 7, no. 2 (2020): 9–17. http://dx.doi.org/10.1530/erp-19-0034.

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Background Chronic mitral regurgitation (MR) historically has been shown to primarily affect left ventricular (LV) function. The impact of increased left atrial (LA) volume in MR on morbidity and mortality has been highlighted recently, yet the LA does not feature as prominently in the current guidelines as the LV. Thus, we aimed to study LA and LV function in chronic rheumatic MR using traditional volumetric parameters and strain imaging. Methods Seventy-seven patients with isolated moderate or severe chronic rheumatic MR and 40 controls underwent echocardiographic examination. LV and LA func

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Pagel, Paul S., Dermot Lowe, Douglas A. Hettrick, et al. "Isoflurane, but Not Halothane, Improves Indices of Diastolic Performance in Dogs with Rapid Ventricular, Pacing-induced Cardiomyopathy." Anesthesiology 85, no. 3 (1996): 644–54. http://dx.doi.org/10.1097/00000542-199609000-00025.

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Background The left ventricular (LV) mechanical effects of isoflurane and halothane were examined in dogs with rapid LV pacing-induced cardiomyopathy. These experiments tested the hypothesis that isoflurane and halothane differentially enhance indices of diastolic performance in dogs with moderate LV dysfunction. Methods Eight dogs were chronically instrumented for measurement of LV and aortic pressures, subendocardial segment length, and cardiac output. Contractility was quantified by preload recruitable stroke work (Mw). Diastolic function was evaluated with a time constant of isovolumic rel

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Shvets, D. A., and S. V. Povetkin. "Limitations of Diagnosis of Ischemic Left Ventricular Dysfunction Using the Values of Strain, Twist and Untwist in Patients With Myocardial Infarction of Various Localization." Kardiologiia 64, no. 3 (2024): 55–62. http://dx.doi.org/10.18087/cardio.2024.3.n2253.

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Aim. To compare capabilities for diagnosing regional and global myocardial dysfunction using the values of longitudinal and circular strain, left ventricular (LV) torsion and untwisting in patients with myocardial infarction (MI) of various locations.Material and methods. Patients included in the study (n=121) were divided into three groups: patients with unstable angina (n=30), patients with anterior MI (n=45), and patients with inferior MI (n=46). Clinical, laboratory and instrumental test were performed, including echocardiography. For a quantitative analysis of LV contractility, the maximu

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Methavigul, Ratikorn, and Komsing Methavigul. "Development of a multivariate model to predict significant coronary artery disease in Thai patients with left ventricular systolic dysfunction and determine the applicability of coronary angiography: a single-center, retrospective, case–control study." Asian Biomedicine 11, no. 5 (2018): 419–25. http://dx.doi.org/10.1515/abm-2018-0017.

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AbstractBackgroundCoronary angiography (CAG) or stress imaging has been performed in almost all Thai patients with left ventricular (LV) systolic dysfunction. If CAG results reveal insignificant coronary stenosis, such patients are diagnosed with nonischemic cardiomyopathy (NICM); however, CAG is considered to provide no benefit and may even harm these patients because it is invasive.ObjectivesTo identify predictors associated with significant coronary artery disease (CAD) (stenosis) in Thai patients with LV systolic dysfunction without angina and without LV regional wall motion abnormality an

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Szekely, Yishay, Yael Lichter, Philippe Taieb, et al. "Spectrum of Cardiac Manifestations in COVID-19." Circulation 142, no. 4 (2020): 342–53. http://dx.doi.org/10.1161/circulationaha.120.047971.

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Background: Information on the cardiac manifestations of coronavirus disease 2019 (COVID-19) is scarce. We performed a systematic and comprehensive echocardiographic evaluation of consecutive patients hospitalized with COVID-19 infection. Methods: One hundred consecutive patients diagnosed with COVID-19 infection underwent complete echocardiographic evaluation within 24 hours of admission and were compared with reference values. Echocardiographic studies included left ventricular (LV) systolic and diastolic function and valve hemodynamics and right ventricular (RV) assessment, as well as lung

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Tveita, Torkjel, Kirsti Ytrehus, Eivind S. P. Myhre, and Olav Hevrøy. "Left ventricular dysfunction following rewarming from experimental hypothermia." Journal of Applied Physiology 85, no. 6 (1998): 2135–39. http://dx.doi.org/10.1152/jappl.1998.85.6.2135.

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This study was aimed at elucidating whether ventricular hypothermia-induced dysfunction persisting after rewarming the unsupported in situ dog heart could be characterized as a systolic, diastolic, or combined disturbance. Core temperature of 8 mongrel dogs was gradually lowered to 25°C and returned to 37°C over a period of 328 min. Systolic function was described by maximum rate of increase in left ventricular (LV) pressure (dP/d tmax), relative segment shortening (SS%), stroke volume (SV), and the load-independent contractility index, preload recruitable stroke work (PRSW). Diastolic functio

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Assa, Solmaz, Johanna Kuipers, Esmée Ettema, et al. "Effect of isolated ultrafiltration and isovolemic dialysis on myocardial perfusion and left ventricular function assessed with13N-NH3positron emission tomography and echocardiography." American Journal of Physiology-Renal Physiology 314, no. 3 (2018): F445—F452. http://dx.doi.org/10.1152/ajprenal.00368.2017.

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Hemodialysis is associated with a fall in myocardial perfusion and may induce regional left ventricular (LV) systolic dysfunction. The pathophysiology of this entity is incompletely understood, and the contribution of ultrafiltration and diffusive dialysis has not been studied. We investigated the effect of isolated ultrafiltration and isovolemic dialysis on myocardial perfusion and LV function. Eight patients (7 male, aged 55 ± 18 yr) underwent 60 min of isolated ultrafiltration and 60 min of isovolemic dialysis in randomized order. Myocardial perfusion was assessed by13N-NH3positron emission

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YIP, Gabriel W., Yan ZHANG, Peggy Y. TAN, et al. "Left ventricular long-axis changes in early diastole and systole: impact of systolic function on diastole." Clinical Science 102, no. 5 (2002): 515–22. http://dx.doi.org/10.1042/cs1020515.

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Impaired long-axis motion is a sensitive marker of systolic myocardial dysfunction, but no data are available that relate long-axis changes in systole with those in diastole, particularly in subjects with diastolic dysfunction and a ‘normal’ left ventricular (LV) ejection fraction. A total of 311 subjects (including 105 normal healthy volunteers) aged 20-89 years with variable degrees of systolic function (LV ejection fraction range 0.15-0.84) and diastolic function were studied using tissue Doppler echocardiography and M-mode echocardiography to determine mean mitral annular amplitude and pea

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Williams, Feifei Z., Ritu Sachdeva, Curtis D. Travers, Karen H. Walson, and Kiran B. Hebbar. "Characterization of Myocardial Dysfunction in Fluid- and Catecholamine-Refractory Pediatric Septic Shock and Its Clinical Significance." Journal of Intensive Care Medicine 34, no. 1 (2016): 17–25. http://dx.doi.org/10.1177/0885066616685247.

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Purpose: Myocardial dysfunction is a known complication in patients with pediatric septic shock (PSS); however, its clinical significance remains unclear. The purpose of this study was to characterize left ventricular (LV) and right ventricular (RV) dysfunction and their prevalence in patients with PSS using echocardiography (echo) and to investigate their associations with the severity of illness and clinical outcomes. Methods: Retrospective chart review between 2010 and 2015 from 2 tertiary care pediatric intensive care units. Study included 78 patients (mean age 9.3 ± 7 years) from birth up

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Kim, June-sung, Youn-Jung Kim, Muyeol Kim, Seung Mok Ryoo, and Won Young Kim. "Association between right ventricle dysfunction and poor outcome in patients with septic shock." Heart 106, no. 21 (2020): 1665–71. http://dx.doi.org/10.1136/heartjnl-2020-316889.

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ObjectiveSepsis-induced myocardial dysfunction (SIMD) can involve both the left and right ventricles. However, the characteristics and outcomes across various manifestations of SIMD remain unknown.MethodsThis was a retrospective cohort study using a prospective registry of septic shock from January 2011 and April 2017. Patients with clinically presumed cardiac dysfunction underwent echocardiography within 72 hours after admission and were enrolled (n=778). SIMD was classified as left ventricle (LV) systolic/diastolic and right ventricle (RV) dysfunction, which were defined based on the America

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Iqbal, Muhammad Khaleel, Muhammad Furrakh Maqbool, Shahzad Tawwab, Usman Mahmood Butt, Imran Saleem, and Tahir Naveed. "Comparison of tissue doppler derived systolic strain between different severities of left ventricular dysfunction in patients having rheumatic severe mitral regurgitation." Journal of Fatima Jinnah Medical University 13, no. 4 (2020): 145–49. http://dx.doi.org/10.37018/jfjmu.631.

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Background: Tissue doppler derived systolic strain detects the subtle changes in left ventricular (LV) function. This new modality can detect LV dysfunction in severe rheumatic mitral regurgitation (MR) at earlier stages. The present study was conducted to compare tissue doppler derived peak systolic strain between patients with different severities of LV dysfunction in rheumatic severe MR and to look for the negative correlation between LV dysfunction and peak systolic strain. Subjects and methods: A descriptive correlational study was conducted from January 2017 to March 2018 at Punjab

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Bioh, Gabriel, Christina Botrous, Emma Howard, Ashish Patel, Reinette Hampson, and Roxy Senior. "Prevalence of cardiac pathology and relation to mortality in a multiethnic population hospitalised with COVID-19." Open Heart 8, no. 2 (2021): e001833. http://dx.doi.org/10.1136/openhrt-2021-001833.

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ObjectiveTo determine the prevalence of cardiac abnormalities and their relationship to markers of myocardial injury and mortality in patients admitted to hospital with COVID-19.MethodsA retrospective and prospective observational study of inpatients referred for transthoracic echocardiography for suspected cardiac pathology due to COVID-19 within a London NHS Trust. Echocardiograms were performed to assess left ventricular (LV), right ventricular (RV) and pulmonary variables along with collection of patient demographics, comorbid conditions, blood biomarkers and outcomes.ResultIn the predomin

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Neil, C., T. Nguyen, M. Chapman, G. Mahadavan, C. Zeitz, and J. Horowitz. "Residual LV Systolic Dysfunction Post-Tako-Tsubo Cardiomyopathy." Heart, Lung and Circulation 21 (January 2012): S258. http://dx.doi.org/10.1016/j.hlc.2012.05.633.

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Rownak Jahan Tamanna, Aparna Rahman, and Shabnam Jahan Hoque. "Correlation of Tricuspid Annular Plane Systolic Excursion (TAPSE), as a predictor of Right Ventricular Systolic Function with Left Ventricular Systolic Function." Bangladesh Critical Care Journal 12, no. 1 (2024): 11–17. http://dx.doi.org/10.3329/bccj.v12i1.72423.

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Introduction: Right Ventricular (RV) function is a strong predictor of outcome in many Cardiovascular Diseases, but its significance is often neglected. Right Ventricle (RV) dysfunction may be secondary to Left Ventricle (LV) dysfunction as a consequence of “Ventricular Interdependence. Tricuspid Annular Plane Systolic Excursion (TAPSE) is an Echocardiographic measure that allows us to assess Right Ventricular systolic function and it correlates well with reference techniques like Cardiac Magnetic Resonance Imaging. Echocardiographic recording of the Tricuspid Annular Plane Systolic Excursion

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Ayoub, Amal Mohamed, Viola William Keddeas, Yasmin Abdelrazek Ali, and Reham Atef El Okl. "Subclinical LV Dysfunction Detection Using Speckle Tracking Echocardiography in Hypertensive Patients with Preserved LV Ejection Fraction." Clinical Medicine Insights: Cardiology 10 (January 2016): CMC.S38407. http://dx.doi.org/10.4137/cmc.s38407.

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Background Early detection of subclinical left ventricular (LV) systolic dysfunction in hypertensive patients is important for the prevention of progression of hypertensive heart disease. Methods We studied 60 hypertensive patients (age ranged from 21 to 49 years, the duration of hypertension ranged from 1 to 18 years) and 30 healthy controls, all had preserved left ventricular ejection fraction (LVEF), detected by two-dimensional speckle tracking echocardiography (2D-STE). Results There was no significant difference between the two groups regarding ejection fraction (EF) by Simpson's method.

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Syvolap, V. V., and V. A. Lysenko. "Is there the phenotype of chronic heart failure with “intermediate” left ventricular ejection fraction? Additional echocardiographic criteria for left ventricular systolic dysfunction in patients with chronic heart failure of ischemic origin with ejection fraction in the “gray area”." Zaporozhye Medical Journal 23, no. 3 (2021): 322–30. http://dx.doi.org/10.14739/2310-1210.2021.3.224710.

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Patients with chronic heart failure (CHF) with left ventricular ejection fraction (LV EF) in the range of 40–55 % form a separate group with “intermediate” or “moderately reduced” LV EF. Since there are a number of additional criteria in echocardiography other than EF for determining LV systolic function (TEI, MAPSE, systolic velocity of the fibrous ring of the mitral valve (S’), E/e’, dP/dt mitral regurgitation, etc.), their use may be helpful in the final identification of systolic dysfunction in CHF patients with LV EF within the “gray area”. The aim of the work – to find out the possibilit

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Flu, Willem-Jan, Jan-Peter van Kuijk, Sanne E. Hoeks, et al. "Prognostic Implications of Asymptomatic Left Ventricular Dysfunction in Patients Undergoing Vascular Surgery." Anesthesiology 112, no. 6 (2010): 1316–24. http://dx.doi.org/10.1097/aln.0b013e3181da89ca.

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Background The prognostic value of heart failure symptoms on postoperative outcome is well acknowledged in perioperative guidelines. The prognostic value of asymptomatic left ventricular (LV) dysfunction remains unknown. This study evaluated the prognostic implications of asymptomatic LV dysfunction in vascular surgery patients assessed with routine echocardiography. Methods Echocardiography was performed preoperatively in 1,005 consecutive vascular surgery patients. Systolic LV dysfunction was defined as LV ejection fraction less than 50%. Ratio of mitral-peak velocity during early and late f

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El Shahawy, Eman S., and Asmaa A. Hassan. "Left ventricular ejection time: its relation to left ventricular systolic function and functional capacity in cardiomyopathic patients." Al-Azhar Assiut Medical Journal 22, no. 2 (2024): 118–26. https://doi.org/10.4103/azmj.azmj_39_24.

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Background and aim Left ventricular ejection time (LVET) was used to evaluate left ventricular function. Transthoracic echocardiogram was done, and parameters of LV systolic function by utilizing tissue Doppler imaging and two-dimensional strain were obtained. Moreover, the New York Heart Association (NYHA) functional class and 6 min walk test (6MWT) was investigated intending to detect the LVET value in the detection of LV systolic dysfunction in patients with dilated cardiomyopathy (DCM) and its relation to a functional capacity to assess the clinical severity of systolic heart failure. Pati

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Chursina, T. Ya, A. M. Kravchenko, and K. O. Mikhaliev. "LEFT VENTRICULAR REMODELING IN HEART FAILURE (PART I): CURRENT UNDERSTANDING OF PATHOMECHANISMS AND RELATED MYOCARDIAL DYSFUNCTION." Клінічна та профілактична медицина 3, no. 21 (2022): 71–83. http://dx.doi.org/10.31612/2616-4868.3(21).2022.11.

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Aim: to provide a literature review of the current data on various pathomechanisms of left ventricular (LV) remodeling in heart failure (HF) patients and their role in the development and progression of myocardial dysfunction. This paper is a first part of the review, devoted to the current state of pathophysiology of LV remodeling in HF. Material and methods. The thematic scientific papers, published during the last decade, constituted the study material. The research methodology involved bibliosemantic method and structural and logical analysis. Results and discussion. LV remodel

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Pereira, Alberto M., Victoria Delgado, Johannes A. Romijn, Johannes W. A. Smit, Jeroen J. Bax, and Richard A. Feelders. "Cardiac dysfunction is reversed upon successful treatment of Cushing's syndrome." European Journal of Endocrinology 162, no. 2 (2010): 331–40. http://dx.doi.org/10.1530/eje-09-0621.

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ObjectiveIn patients with active Cushing's syndrome (CS), cardiac structural and functional changes have been described in a limited number of patients. It is unknown whether these changes reverse after successful treatment. We therefore evaluated the changes in cardiac structure and dysfunction after successful treatment of CS, using more sensitive echocardiographic parameters (based on two-dimensional strain imaging) to detect subtle changes in cardiac structure and function.MethodsIn a prospective study design, we studied 15 consecutive CS patients and 30 controls (matched for age, sex, bod

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Kruchinkina, E. V., T. R. Ryabova, Yu V. Rogovskaya, R. E. Batalov, and V. V. Ryabov. "CHARACTERISTICS OF CLINICAL CURRENT AND STRUCTURAL-FUNCTIONAL STATE OF LEFT VENTRICULAR IN DECOMPENSATION OF CHRONIC HEART FAILURE IN PATIENTS WITH ISCHEMIC CHRONIC HEART FAILURE WITH SYSTOLIC DYSFUNCTION AND INFLAMMATION OF THE MYOCARDIUM." Siberian Medical Journal 33, no. 2 (2018): 26–34. http://dx.doi.org/10.29001/2073-8552-2018-33-2-26-34.

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The aimwas to study the clinical course of CHF decompensation and the structural and functional state of the left ventricle in patients with ischemic CHF with systolic dysfunction and myocardial inflammation.Material and Methods.This study is open, non-randomized, prospective, registered on the ClinicalTrials.gov website, identification number: NCT02649517. The analysis included 25 patients (84% men, LVEF 29.17±9.4%) with ADHF of ischemic etiology. The average age of the patients was 60.12±9.3 years. All the patients underwent an echocardiography including 2D-speckle tracking technique to asse

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Arramraju, Sreenivas Kumar, Rama Krishna Janapati, Sudhakar Reddy Pathakota, Sanjeeva Kumar E, and Gokul Reddy Mandala. "Reversible LV Dysfunction After TAVR." Indian Journal of Clinical Cardiology 1, no. 1 (2020): 17–19. http://dx.doi.org/10.1177/2632463619899567.

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Aortic stenosis (AS) is characterized by gradual thickening, fibrosis, and calcification leading to reduced opening of aortic valve leaflets. Aortic valve narrowing increases the afterload on left ventricle (LV), which consequently leads to hypertrophy and myocardial fibrosis which over a period of time leads to diastolic dysfunction. LV diastolic dysfunction is an independent predictor of heart failure rehospitalization and mortality in post-aortic valve replacement patients. Chronic pressure overload leads to development of systolic dysfunction due to afterload mismatch. Patients with severe

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Dent, J. M., W. D. Spotnitz, S. P. Nolan, A. R. Jayaweera, W. P. Glasheen, and S. Kaul. "Mechanism of mitral leaflet excursion." American Journal of Physiology-Heart and Circulatory Physiology 269, no. 6 (1995): H2100—H2108. http://dx.doi.org/10.1152/ajpheart.1995.269.6.h2100.

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The factors that influence the extent of mitral leaflet opening (MLO) and closure (MLC) have not been defined. We hypothesized that left ventricular (LV) systolic function determines the rate of increase of the early diastolic left atrial (LA)-LV pressure gradient, which is responsible for the extent of MLO, and also the rate of change of the early systolic LV-LA pressure gradient, which determines the degree of MLC. Accordingly, global LV function was changed by altering left main coronary artery flow with LA pressure held relatively constant. LV end-systolic dimension and peak positive LV ra

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Panda, Dr Sibaram, and Dr Sunil Kumar Sharma. "Cardiac evaluation of Covid-19 patients with post-discharge dyspnoea." International Journal of Medical Research & Review 8, no. 6 (2020): 432–37. http://dx.doi.org/10.17511/ijmrr.2020.i06.11.

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Background: Dyspnoea is one of the common symptoms in COVID-19 patients after discharge fromthe hospital. So evaluation of cardiac function becomes necessary in COVID patients after hospitaldischarge. AIM: To study the cardiac function of COVID 19 patients presenting with dyspnoea afterdischarge from hospital within 3 months of symptom onset. Materials and methods: 245 post-hospital discharge COVID-19 patients enrolled in the study. The patients with abnormalechocardiography are further divided into three groups, A) patients with PAH±RVD, B) patients withLV diastolic dysfunction C) patients wi

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Roy, Rajesh, Bhagirath Solanki, Niraj Chawda, et al. "Cardiac function’s in patients with chronic kidney disease." International Journal of Advances in Medicine 10, no. 1 (2022): 59. http://dx.doi.org/10.18203/2349-3933.ijam20223402.

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Background: To assess the cardiac functions in patients with chronic kidney disease (CKD).Methods: 150 patients with CKD were randomly selected. 12 lead ECG were performed to detect CVD. All Patients were diagnosed with CKD. The left ventricular ejection fraction (LVEF) and fractional shortening (FS) were taken as measures of LV systolic function. Diastolic function was determined by measuring early to late peak velocities (E/A) ratio by spectral Doppler LV inflow velocity. Results: Male: female 95 and 55, hypertension 67% was leading cause of CKD. Diastolic dysfunction as denoted by E/A ratio

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SHANG, QING, LAI-SHAN TAM, GABRIEL WAI-KWOK YIP, et al. "High Prevalence of Subclinical Left Ventricular Dysfunction in Patients with Psoriatic Arthritis." Journal of Rheumatology 38, no. 7 (2011): 1363–70. http://dx.doi.org/10.3899/jrheum.101136.

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Objective.Endothelial dysfunction and early atherosclerosis have been found in patients with psoriatic arthritis (PsA) without cardiovascular disease (CVD) risk factors. Few studies have investigated whether there is any early impairment of myocardial function. The aims of our study were to determine the prevalence of subclinical left ventricular (LV) dysfunction in PsA patients and the disease-related risk factors.Methods.Ninety-four PsA patients without clinical evidence of CVD and 63 healthy subjects were enrolled. All underwent conventional echocardiography and tissue Doppler imaging.Resul

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Kuga, T., M. Matsushita, K. Tada, K. Yamaji, and N. Tamura. "AB0422 LEFT VENTRICULAR ABNORMALITIES IN SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS FOLLOWED BY SEQUENTIAL ECHOCARDIOGRAPHY." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1510.1–1511. http://dx.doi.org/10.1136/annrheumdis-2020-eular.1941.

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Background:Cardiovascular disease (CVD) is detected in up to 50% of systemic lupus erythematosus (SLE) patients1and major cause of death2. Even clinically silent SLE patients can develop left ventricular (LV) diastolic dysfunction3. Proper echocardiographic follow up of SLE patients is required.Objectives:To clarify how the prevalence of LV abnormalities changes over follow-up period and identify the associated clinical factors, useful in suspecting LV abnormalities.Methods:29 SLE patients (24 females and 5 men, mean age 52.8±16.3 years, mean disease duration 17.6±14.5 years) were enrolled. Al

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Bordun, Kimberly-Ann, Sheena Premecz, Megan daSilva, et al. "The utility of cardiac biomarkers and echocardiography for the early detection of bevacizumab- and sunitinib-mediated cardiotoxicity." American Journal of Physiology-Heart and Circulatory Physiology 309, no. 4 (2015): H692—H701. http://dx.doi.org/10.1152/ajpheart.00172.2015.

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The recent introduction of novel anticancer therapies, including bevacizumab (BVZ) and sunitinib (SNT), is associated with an increased risk of cardiotoxicity. However, early identification of left ventricular (LV) systolic dysfunction may facilitate dose modification and avoid the development of advanced heart failure. Using a murine model of BVZ- and SNT-mediated cardiotoxicity, we investigated whether cardiac biomarkers and/or tissue velocity imaging (TVI) using echocardiography can detect early changes in cardiac function, before a decrease in LV ejection fraction is identified. A total of

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Gamrat, Aleksandra, Michał A. Surdacki, Bernadeta Chyrchel, and Andrzej Surdacki. "Endothelial Dysfunction: A Contributor to Adverse Cardiovascular Remodeling and Heart Failure Development in Type 2 Diabetes beyond Accelerated Atherogenesis." Journal of Clinical Medicine 9, no. 7 (2020): 2090. http://dx.doi.org/10.3390/jcm9072090.

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Endothelial dysfunction, associated with depressed nitric oxide (NO) bioavailability, is a well-recognized contributor to both accelerated atherogenesis and microvascular complications in type 2 diabetes (DM). However, growing evidence points to the comorbidities-driven endothelial dysfunction within coronary microvessels as a key player responsible for left ventricular (LV) diastolic dysfunction, restrictive LV remodeling and heart failure with preserved ejection fraction (HFpEF), the most common form of heart failure in DM. In this review we have described: (1) multiple cellular pathways whi

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Toldo, Stefano, Eleonora Mezzaroma, Laura O'Brien, et al. "Interleukin-18 mediates interleukin-1-induced cardiac dysfunction." American Journal of Physiology-Heart and Circulatory Physiology 306, no. 7 (2014): H1025—H1031. http://dx.doi.org/10.1152/ajpheart.00795.2013.

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Patients with heart failure (HF) have enhanced systemic IL-1 activity, and, in the experimental mouse model, IL-1 induces left ventricular (LV) systolic dysfunction. Whether the effects of IL-1 are direct or mediated by an inducible cytokine, such as IL-18, is unknown. Recombinant human IL-18-binding protein (IL-18BP) or an IL-18-blocking antibody (IL-18AB) was used to neutralize endogenous IL-18 after challenge with the plasma of patients with HF or with recombinant murine IL-1β in adult male mice. Plasma levels of IL-18 and IL-6 (a key mediator of IL-1-induced systemic effects) and LV fracti

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van Wijngaarden, Suzanne E., Samira Ben Said-Bouyeri, Maarten K. Ninaber, et al. "Progression of Left Ventricular Myocardial Dysfunction in Systemic Sclerosis: A Speckle-tracking Strain Echocardiography Study." Journal of Rheumatology 46, no. 4 (2019): 405–15. http://dx.doi.org/10.3899/jrheum.171207.

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Objective.Cardiac involvement is a main cause of mortality in systemic sclerosis (SSc). Its detection remains challenging using conventional echocardiography and little is known about its potential progression. This study assessed changes in cardiac performance over time in a prospective cohort of patients with SSc, including echocardiographic speckle-tracking strain analysis.Methods.The study included 234 patients with SSc [196 women, age 52 ± 14 yrs, 165 limited SSc, time since diagnosis 5.2 yrs, interquartile range (IQR) 2.9–11.3]. Clinical variables, laboratory tests, pulmonary function te

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Leelapatana, Pattranee, Charat Thongprayoon, Narut Prasitlumkum, Saraschandra Vallabhajosyula, Wisit Cheungpasitporn, and Ronpichai Chokesuwattanaskul. "Role of Ranolazine in the Prevention and Treatment of Atrial Fibrillation in Patients with Left Ventricular Systolic Dysfunction: A Meta-Analysis of Randomized Clinical Trials." Diseases 9, no. 2 (2021): 31. http://dx.doi.org/10.3390/diseases9020031.

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Background: Ranolazine has the potential to prevent atrial fibrillation (AF) and plays a role in rhythm control strategy for atrial fibrillation in various clinical settings. However, data on the use of ranolazine in patients with left ventricular (LV) systolic dysfunction are limited. The aims of this meta-analysis of randomized clinical trials are to investigate the efficacy and safety of ranolazine in AF patients with LV systolic dysfunction. PubMed and the Cochrane Database of Systematic Reviews were searched until July 2020. The efficacy outcomes included the incidence of new-onset AF, th

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Al-Jawahiri, Thamer I., and Amal N. Al-Marayati,. "Early Detection of Left Ventricular Systolic Dysfunction in Asymptomatic Patients with Chronic Aortic Regurgitation by two Dimensional Speckle Tracking Echocardiography." AL-Kindy College Medical Journal 14, no. 2 (2019): 35–42. http://dx.doi.org/10.47723/kcmj.v14i2.49.

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Background: Early detection of subclinical left ventricular (LV) systolic dysfunction is crucial and could inﬂuence patients' prognosis by aiding the clinician to candidate patients for better management. Objective: To detect early LV systolic dysfunction in asymptomatic patient with chronic aortic regurgitation by two dimensional speckle tracking echocardiography. Methods: Sixty one asymptomatic patients with chronic aortic regurgitation, with no ischemic heart diseases (by coronary angiography) or conductive heart diseases, no diabetes mellitus, no hypertension, and no other valv

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Thakur, Saru, Geeta Ram Tegta, Prakash Chand Negi, et al. "Echocardiographic Prevalence and Risk Predictors of Ventricular Dysfunction in Connective Tissue Disorders: Tertiary Care Hospital-Based Prospective Case-Control Study." Indian Journal of Clinical Cardiology 1, no. 3-4 (2020): 132–41. http://dx.doi.org/10.1177/2632463620966143.

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Background: There is a paucity of contemporary Indian data about the prevalence of cardiac abnormalities in patients of connective tissue disorders (CTD) and their risk determinants. Methods: We prospectively recorded data from 35 consecutive CTD patients who presented to our out-patient department and had no significant cardiovascular risk factors at baseline. We also recorded data from their age- and sex-matched controls. All cases and controls were subjected to 12 lead electrocardiogram and echocardiography after routine investigations. Results: The CTD group comprised 19 (54.3%) patients o

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Rekhraj, Sushma, Benjamin Szwejkowski, and Allan Struthers. "Reducing Cardiovascular Risk in Patients following MI with Eplerenone." Clinical Medicine Insights: Therapeutics 2 (January 2010): CMT.S5231. http://dx.doi.org/10.4137/cmt.s5231.

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Background In the event of an MI, the presence of LV systolic dysfunction with or without heart failure is associated with a poorer prognosis. Elevation of aldosterone levels also results in a poor prognosis after an MI. Objective This review discusses the cardiovascular benefits of blocking the aldosterone receptor using eplerenone therapy in post MI patients. Methods A literature search of Pubmed was conducted for relevant English language articles published between 1990–2010 using the search terms eplerenone, aldosterone, myocardial infarction, heart failure and endothelial dysfunction. Add

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Cojocaru, Cosmin, Silvia Deaconu, Viviana Gondos, et al. "Complex Substrate Leading to PVC-Mediated Systolic Dysfunction in addition to Sustained Monomorphic VT in Repaired Tetralogy of Fallot." Diagnostics 14, no. 2 (2024): 158. http://dx.doi.org/10.3390/diagnostics14020158.

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Frequent premature ventricular complexes (PVCs) are associated with deleterious effects on left ventricular (LV) function in various clinical scenarios. Repaired tetralogy of Fallot (rTOF) is frequently affected by sustained ventricular arrhythmias dependent on complex post-surgical substrates. However, there is limited data regarding the potential of arrhythmogenic isthmuses to generate frequent PVCs and PVC-mediated LV systolic dysfunction development in rTOF. We present a case of rTOF experiencing relatively infrequent episodes of internal shocks for episodes of sustained monomorphic ventri

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Martins Barros, Isabella Morais, Marcio Vinicius L. Barros, Larissa Natany Almeida Martins, et al. "Accuracy and reliability of focused echocardiography in patients with Chagas disease from endemic areas: SaMi-Trop cohort study." PLOS ONE 16, no. 11 (2021): e0258767. http://dx.doi.org/10.1371/journal.pone.0258767.

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Background Chagas disease remains a major cause of cardiovascular death in endemic areas. Focused echocardiography (FoCUS) is a point-of-care means of assessing cardiac function which can be useful for the diagnosis of cardiac involvement. Objective This study aims evaluating the characteristics of validity and reliability of FoCUS applied on Chagas disease patients. Methods Patients with Chagas disease coming from an endemic area were selected from a large cohort (SaMi-Trop). A simplified echocardiogram with only three images was extracted from the conventional echocardiogram performed in thi

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