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Relevant bibliographies by topics / Lymph node;breast cancer;detection / Dissertations / Theses

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Dissertations / Theses on the topic 'Lymph node;breast cancer;detection'

Author: Grafiati

Published: 4 June 2021

Last updated: 21 February 2023

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1

Chen, Wan Qing. "Predictors of Auxillary Lymph Node Involvement in Screen Detected Breast Cancer." Thesis, The University of Sydney, 2004. http://hdl.handle.net/2123/676.

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Background: Axillary lymph node dissection as routine part of breast cancer treatment has been questioned in relation to the balance between benefits and morbidity. The purpose of this study is to determine the association of tumor size, age and histological grade with axillary lymph node metastasis, to determine if some patients could be exempted from axillary dissection. Methods: The data are derived from BreastScreen NSW, the government sponsored population-based breast screening program. In New South Wales (NSW) Australia between 1995 and 2002, 7,221 patients with invasive breast carcino

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Chen, Wan Qing. "Predictors of Auxillary Lymph Node Involvement in Screen Detected Breast Cancer." University of Sydney. Public Health, 2004. http://hdl.handle.net/2123/676.

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Background: Axillary lymph node dissection as routine part of breast cancer treatment has been questioned in relation to the balance between benefits and morbidity. The purpose of this study is to determine the association of tumor size, age and histological grade with axillary lymph node metastasis, to determine if some patients could be exempted from axillary dissection. Methods: The data are derived from BreastScreen NSW, the government sponsored population-based breast screening program. In New South Wales (NSW) Australia between 1995 and 2002, 7,221 patients with invasive breast carcino

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Doting, Meintje Hylkje Edwina. "Sentinel lymph node biopsy in breast cancer and melanoma." [S.l. : [Groningen : s.n.] ; University Library Groningen] [Host], 2007. http://irs.ub.rug.nl/ppn/300326254.

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Chen, Wanqing. "Predictors of axillary lymph node involvement in screen-detected breast cancer." Connect to full text, 2004. http://setis.library.usyd.edu.au/adt/public_html/adt-NU/public/adt-NU20050104.165451/index.html.

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Thesis (M.I.P.H.)--School of Public Health, University of Sydney, 2004.<br>"This treatise is submitted in partial satisfaction of the requirements for the Degree of Master of International Public Health (Hons), University of Sydney". Bibliography: leaves 10-15.

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5

Ahlgren, Johan. "Studies on Prediction of Axillary Lymph Node Status in Invasive Breast Cancer." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2002. http://publications.uu.se/theses/91-554-5221-3/.

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6

Johnson, Laura. "Magnetic nanoparticles for sentinel lymph node imaging and biopsy in breast cancer." Thesis, King's College London (University of London), 2012. https://kclpure.kcl.ac.uk/portal/en/theses/magnetic-nanoparticles-for-sentinel-lymph-node-imaging-and-biopsy-in-breast-cancer(978692de-a495-4df1-ac0f-303227bed0dd).html.

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Background Axillary nodal status is the single most important prognostic factor in breast cancer diagnosis. If cancerous cells are present, the sentinel lymph node (SLN) is the axillary lymph node that is most likely to contain metastatic disease. In early stage breast cancer, the SLN is localised (then surgically removed for pathological analysis) using a radioisotope and/or a blue dye injected into the breast Super-paramagnetic iron oxide (SPIO) nanoparticles are novel agents that, when injected, could potentially both localise and characterise the SLN using MRI such that surgical SLN biopsy

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Bhattarai, Nihit. "Differentiation Mechanisms of Myeloid-Lymphatic Progenitors that Promote Lymph Node Metastasis in Breast Cancer." OpenSIUC, 2020. https://opensiuc.lib.siu.edu/theses/2657.

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Metastasis to distant organs, a major cause of mortality from cancer, is often preceded by tumor spread to regional lymph nodes (LN). This process is supported exclusively by lymphatic vessels within or around the tumor. It is important to understand the mechanism by which tumors induce generation of new lymphatic vessels because interference with this early stage of tumor spread might prevent distant metastasis. Tumor lymphatic formation is thought to be induced by VEGF-C factor that activates its receptor VEGFR-3 expressed in lymphatic endothelial cells (LEC). However, this process also requ

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Owusu, Miriam Sekyere. "Lymphedema, post breast cancer treatment at Komfo Anokye Teaching Hospital, Kumasi, Ghana." Thesis, Cape Peninsula University of Technology, 2011. http://hdl.handle.net/20.500.11838/2262.

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Thesis (MTech (Nursing))--Cape Peninsula University of Technology, 2011.<br>To determine the incidence, risk factors and the treatment of lymphedema after breast cancer treatment at the oncology unit of KATH, Kumasi, Ghana from 01 January 2005 to 31 December 2008. Descriptive retrospective survey was used. Using a data capture sheet, data was collected from the medical records of the breast cancer patients. Breast cancer and lymphedema-related variables were collected. Data was analyzed as descriptive statistics. Chi-square test was applied to determine whether or not two variables are

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9

de, Boniface Jana. "Sentinel Node Biopsy in Breast Cancer : Clinical and Immunological Aspects." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7890.

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Vasques, Paulo Henrique DiÃgenes. "Comparison between hemosiderin and technetium-99 in the identification of sentinel lymph node in breast cancer." Universidade Federal do CearÃ, 2016. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=16007.

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CoordenaÃÃo de AperfeÃoamento de Pessoal de NÃvel Superior<br>Introduction and objective: Sentinel Lymph Node Biopsy (SLNB) has currently replaced axillary dissection in early-stage breast cancer in clinically tumor-free patients. Technetium-99 (99Tc) is the gold standard for the identification of Breast Sentinel Lymph Node (SLN). Blue dyes are a less expensive and widely used option in Brazil. These dyes are responsible for several adverse and hypersensitivity reactions that â although rare â can put patientsâ lives at risk. There is an interest in the discovery of new equivalent substances

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11

Celebioglu, Fuat. "Sentinel node biopsy in breast cancer : aspects on validation, diagnostics and lymphatic drainage pattern /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-772-3/.

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12

Greene, Carmen M. "Experience using a small field of view gamma camera for intraoperative sentinel lymph node procedures." Thesis, Available online, Georgia Institute of Technology, 2006, 2006. http://etd.gatech.edu/theses/available/etd-01132006-160335/.

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13

Kano, Masato. "Detection of Lymph Node Metasatasis of Oesophageal Cancer by RT-nested PCR for SCC antigen mRNA." Kyoto University, 2001. http://hdl.handle.net/2433/150176.

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14

Griggs, Caitlin Elizabeth. "Generation of myeloid-derived lymphatic endothelial cell progenitors (M-LECPs) by TLR4-mediated inflammation and de novo VEGFR-3 signaling in breast cancer." OpenSIUC, 2016. https://opensiuc.lib.siu.edu/theses/1902.

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Breast cancer is the second leading cause of cancer-related death in women in the United States. Complications that lead to mortality of cancer patients are associated with tumor metastasis. Specifically, lymphatic metastasis in breast cancer patients strongly correlates with poor patient survival and this process is facilitated by the formation of new tumor lymphatic vessels termed lymphangiogenesis. Previously, our lab reported that lymphangiogenesis was promoted by a distinct subset of bone marrow (BM)-derived myeloid cells that co-express lymphatic-specific markers designated as myeloid-de

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Jafer, Fatema. "THE CLINICAL VALUE OF SPECT/ CT IN IDENTIFYINGSENTINEL LYMPH NODES IN PATIENTS WITH BREASTCANCER: A SYSTEMATIC REVIEW." Thesis, Örebro universitet, Institutionen för medicinska vetenskaper, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-94687.

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Introduction: Sentinel lymph node biopsy is an established method used to investigate the riskof lymphatic metastasis especially in breast cancer and melanoma patients. SPECT/ CT isconsidered to be an advantageous method in mapping of sentinel nodes. Aim: The aim of this systematic literature review was to investigate the clinical value ofSPECT/ CT in the detection of sentinel lymph nodes in breast cancer patients. Method: Using specific search terms the database PubMed was used to find studies of potentialrelevance for this systematic review. Criteria for inclusions and exclusion were decided

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Takada, Masahiro. "Prediction of axillary lymph node metastasis and the pathological response to neoadjuvant chemotherapy in patients with primary breast cancer using a decision tree-based model." Kyoto University, 2012. http://hdl.handle.net/2433/160969.

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Matheus, Carolina Nascimben 1980. "Avaliação do fluxo sanguíneo do membro superior de mulheres submetidas a abordagem axilar para tratamento do câncer de mama : Blood flow in the superior limbs of women with breast cancer undergoing a surgical approach to the axilla." [s.n.], 2015. http://repositorio.unicamp.br/jspui/handle/REPOSIP/312844.

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Orientador: Luís Otávio Zanatta Sarian<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-27T18:24:57Z (GMT). No. of bitstreams: 1 Matheus_CarolinaNascimben_D.pdf: 2850729 bytes, checksum: fd170a425e039c6e8f1324b637393c8b (MD5) Previous issue date: 2015<br>Resumo: Objetivo: Esta tese visou avaliar os parâmetros vasculares arteriais e venosos dos vasos axilares e braquiais em mulheres submetidas a tratamento para câncer de mama. Subdividimos estas avaliações conforme os objetivos abordados em duas publicações, respecti

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Alvarenga, César Augusto 1975. "Tipos especiais histológicos de carcinomas da mama = perfil imunoistoquímico com ênfase na classificação molecular." [s.n.], 2011. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310564.

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Orientadores: Luiz Carlos Zeferino, Fernando Carlos de Landér Schmitt<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-19T10:11:46Z (GMT). No. of bitstreams: 1 Alvarenga_CesarAugusto_D.pdf: 4979947 bytes, checksum: 8da78ad01d29e47c7c97bb4d231ee04b (MD5) Previous issue date: 2011<br>Resumo: A maioria dos carcinomas invasivos da mama são classificados como carcinoma ductal invasivo, sem outras especificações (CDI-SOE), enquanto que cerca de 25% são definidos como tipos especiais histológicos (TEH). Esses TEH de carcin

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Delazeri, Gerson Jacob. "Injeção intraoperatória de dextran-500-99m tecnécio para identificação do linfonodo sentinela em câncer de mama." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2010. http://hdl.handle.net/10183/25113.

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Objetivos: Avaliar a eficácia da injeção intraoperatória para identificação do linfonodo sentinela (LS) em câncer de mama com o uso do Dextran 500-99m-Tecnécio (Tc) e azul patente. Analisar se as doses do radiofármaco, o IMC (índice de massa corporal) e o volume da mama influenciam no tempo para migração ao LS. Metodologia: Estudo prospectivo, realizado entre abril de 2008 e junho de 2009, que incluiu 74 biópsias de LS em pacientes com câncer de mama em estádios T1N0 e T2N0. Injetou-se, após indução anestésica, de 0,5 a 1,5 mCi de Dextran 500-99m-Tc filtrado 0,22 μm na região subareolar num vo

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Fontana, Vivian. "Extensão do comprometimento axilar após biópsia de linfonodo sentinela positivo nas pacientes com câncer de mama operadas no Hospital de Clínicas de Porto Alegre." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2017. http://hdl.handle.net/10183/164317.

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Introdução: o status dos linfonodos axilares permanece um dos mais importantes fatores prognósticos no carcinoma de mama em estágios iniciais, além de definir o uso de terapias complementares. A biópsia de linfonodo sentinela (BLNS) surgiu com a finalidade de estadiar a axila com o mínimo de morbidade, tendo como objetivo a identificação e o estudo patológico do primeiro linfonodo axilar proveniente da drenagem linfática da mama. Pacientes com axila clinicamente negativa têm indicação de biópsia de linfonodo sentinela como método de estadiamento da axila, e quando o resultado era positivo para

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Bernardes, Franciele Cristina. "Caracterização dos padrões de drenagem linfática nas linfocintilografias de pacientes com câncer de mama." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/82/82131/tde-17072012-085250/.

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O câncer de mama (CA de mama), com exceção do câncer de pele do tipo não melanoma, é o tumor de maior incidência dentre as mulheres, sendo que no Brasil são encontrados principalmente nas regiões Sul e Sudeste. Seu principal tratamento é o cirúrgico. A disseminação do tumor pode ocorrer por via linfática, acometendo linfonodos regionais. A biópsia do linfonodo sentinela (BLNS) é um procedimento altamente relevante, é altamente sensível na identificação de metástases. A técnica de linfocintilografia (LINCT) pré-operatória é essencial, pois permite avaliar a cadeia linfática acometida e possibil

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22

Pelon, Floriane. "Fibroblastic heterogeneity and metastatic spread in breast cancers Fibroblast heterogeneity drives metastatic spread in breast cancer through distinct mechanisms." Thesis, Sorbonne Paris Cité, 2018. https://wo.app.u-paris.fr/cgi-bin/WebObjects/TheseWeb.woa/wa/show?t=2392&f=17330.

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Les cancers du sein, premiers cancers féminins et causes aujourd’hui encore de nombreux décès, sont classés en 3 sous-types moléculaires : luminaux –les plus répandus, HER2 et triple-négatifs (TN) –les plus agressifs. Lors du diagnostic, l’envahissement des ganglions lymphatiques axillaires par les cellules tumorales est établi. Il s’agit, en plus de la classification moléculaire, d’un marqueur pronostique utilisé en clinique pour stratifier les patientes, car il informe sur le risque de développement ultérieur de métastases, cause majeure des décès à l’heure actuelle. Les tumeurs solides, et

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McCosker, Helen Clare. "Prognostic significance of IGF and ECM induced signalling proteins in breast cancer patients." Thesis, Queensland University of Technology, 2012. https://eprints.qut.edu.au/53580/1/Helen_McCosker_Thesis.pdf.

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Breast cancer is a leading contributor to the burden of disease in Australia. Fortunately, the recent introduction of diverse therapeutic strategies have improved the survival outcome for many women. Despite this, the clinical management of breast cancer remains problematic as not all approaches are sufficiently sophisticated to take into account the heterogeneity of this disease and are unable to predict disease progression, in particular, metastasis. As such, women with good prognostic outcomes are exposed to the side effects of therapies without added benefit. Furthermore, women with aggres

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Teixeira, Patricia Akissue de Camargo. "Desempenho da ultrassonografia e da punção aspirativa por agulha fina axilar em pacientes com carcinomas invasivos da mama: correlação com aspectos do linfonodo e características tumorais." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/5/5151/tde-14112017-162244/.

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INTRODUÇÃO: O status linfonodal da axila ainda permanece como importante fator prognóstico em pacientes com câncer de mama invasivo. Muitos estudos já relataram a importância da ultrassonografia axilar e da punção aspirativa por agulha fina (PAAF) na avaliação pré-operatória das pacientes com câncer de mama. Nossos objetivos foram avaliar as características ultrassonográficas dos linfonodos axilares relacionadas à metástase linfonodal e o papel da PAAF na avaliação pré-operatória de pacientes com câncer de mama. Nosso objetivo secundário foi avaliar se, dependendo das características dos tumor

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Peña, González Karla. "Estudio del ganglio centinela por método molecular en pacientes con cáncer de mama y axila clínicamente negativa que han recibido quimioterapia neoadyuvante." Doctoral thesis, Universitat Rovira i Virgili, 2018. http://hdl.handle.net/10803/664575.

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Antecedents: El càncer de mama és el tumor més freqüent en les dones occidentals. En les últimes dècades s'ha reconegut i estudiat l'heterogeneïtat dels carcinomes de mama, i mitjançant l'ús d'anàlisi de l'expressió gènica, s'han pogut identificar diversos subtipus moleculars i en la pràctica clínica diària s'ha adaptat l'ús de marcadors immunohistoquímics per identificar-los de manera rutinària. La quimioteràpia neoadjuvant (QNA) s'ha utilitzat àmpliament per tractar el càncer de mama i la resposta d'un tumor al tractament sistèmic es relaciona amb un increment en la supervivència a llarg ter

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Antonio, Heriton Marcelo Ribeiro. "Linfonodo sentinela e dissecção axilar: análise da disfunção de membros superiores." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/17/17145/tde-05012016-104011/.

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O câncer de mama é a neoplasia maligna que mais acomete as mulheres na população brasileira. Atualmente o tratamento para o câncer de mama está fundamentado em três pilares: radioterapia, cirurgia em suas diversas técnicas, quimioterapia/hormonioterapia. A qualidade de vida pode ser afetada de uma forma geral, envolvendo os aspectos físicos, psicológicos, sociológicos, emocionais, entre outros. O objetivo deste estudo foi comparar a função do membro superior em pacientes com câncer de mama que foram submetidas à biópsia de linfonodo sentinela com as submetidas à dissecção axilar, e que não for

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Morais, Fernanda Dorneles de. "Qualidade de vida e morbidade tardia após a biópsia do linfonodo sentinela ou linfadenectomia axilar em mulheres submetidas ao tratamento do câncer de mama." Universidade Federal de Goiás, 2014. http://repositorio.bc.ufg.br/tede/handle/tede/6442.

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Submitted by Jaqueline Silva (jtas29@gmail.com) on 2016-10-25T17:17:35Z No. of bitstreams: 2 Dissertação - Fernanda Dorneles de Morais - 2014.pdf: 4082854 bytes, checksum: db2b8638cb0a746a19314231d5bdcb13 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)<br>Approved for entry into archive by Jaqueline Silva (jtas29@gmail.com) on 2016-10-25T17:18:02Z (GMT) No. of bitstreams: 2 Dissertação - Fernanda Dorneles de Morais - 2014.pdf: 4082854 bytes, checksum: db2b8638cb0a746a19314231d5bdcb13 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)<br>Ma

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Bosch, Príncep Ramon. "Cel·lularitat immune als ganglis limfàtics axil·lars negatius en pacients amb càncer de mama." Doctoral thesis, Universitat Rovira i Virgili, 2020. http://hdl.handle.net/10803/670599.

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Introducció: Les cèl·lules tumorals poden modificar la resposta immune en tumors primaris i en els ganglis limfàtics axil·lars amb metàstasis (GLA+) en el càncer de mama (CM), la qual cosa influeix en l'evolució de la pacient. Investiguem si els patrons de cèl·lules immunes en el tumor primari i en els ganglis limfàtics axil·lars sense metàstasi (GLA-) difereixen entre les pacients diagnosticades sense GLA+ (pdGLA-) i amb GLA+ (pdGLA+) i les implicacions per a l'evolució clínica. Material i mètodes: Es van estudiar 11 marcadors immunes utilitzant immunohistoquímica, matrius multiteixit i an

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Hamy, Anne-Sophie. "Identification of Factors Predicting Sensitivity or Resistance to Neoadjuvant Chemotherapy in Breast Cancer Neoadjuvant treatment : the future of patients with breast cancer Neoadjuvant treatment for intermediate/high-risk HER2-positive and triple-negative breast cancers: no longer an “option” but an ethical obligation Long-term outcome of the REMAGUS 02 trial, a multicenter randomised phase II trial in locally advanced breast cancer patients treated with neoadjuvant chemotherapy with or without celecoxib or trastuzumab according to HER2 status BIRC5 (survivin) : a pejorative prognostic marker in stage II/III breast cancer with no response to neoadjuvant chemotherapy Beyond Axillary Lymph Node Metastasis, BMI and Menopausal Status Are Prognostic Determinants for Triple-Negative Breast Cancer Treated by Neoadjuvant Chemotherapy Pathological complete response and prognosis after neoadjuvant chemotherapy for HER2-positive breast cancers before and after trastuzumab era: results from a real-life cohort The presence of an in situ component on pre-treatment biopsy is not associated with response to neoadjuvant chemotherapy for breast cancer Chemosensitivity, tumor infiltrating lymphocytes (TILs), and survival of postpartum PABC patients treated by neoadjuvant chemotherapy Lymphovascular invasion after neoadjuvant chemotherapy is strongly associated with poor prognosis in breast carcinoma New insight for pharmacogenomics studies from the transcriptional analysis of two large-scale cancer cell line panels Biological network-driven gene selection identifies a stromal immune module as a key determinant of triple-negative breast carcinoma prognosis A Stromal Immune Module Correlated with the Response to Neoadjuvant Chemotherapy, Prognosis and Lymphocyte Infiltration in HER2-Positive Breast Carcinoma Is Inversely Correlated with Hormonal Pathways Stromal lymphocyte infiltration after neoadjuvant chemotherapy is associated with aggressive residual disease and lower disease-free survival in HER2-positive breast cancer Interaction between molecular subtypes, stromal immune infiltration before and after treatment in breast cancer patients treated with neoadjuvant chemotherapy COX2/PTGS2 Expression Is Predictive of Response to Neoadjuvant Celecoxib in HER2-negative Breast Cancer Patients Celecoxib With Neoadjuvant Chemotherapy for Breast Cancer Might Worsen Outcomes Differentially by COX-2 Expression and ER Status: Exploratory Analysis of the REMAGUS02 Trial Comedications influence immune infiltration and pathological response to neoadjuvant chemotherapy in breast cancer." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS129.

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La chimiothérapie néoadjuvante (CNA) est utilisée dans les cancers du sein agressifs ou localement avancés (CS). Au delà des bénéfices cliniques, elle représente une opportunité pour monitorer in vivo la sensibilité d’une tumeur à un traitement.A partir de l’analyse de sets de données de patients traités par CNA, nous souhaitons identifier des mécanismes associes à la résistance ou sensibilité au traitement. Dans la première partie, nous avons évalué des paramètres, cliniques, anatomopathologiques et transcriptomiques. Nous avons démontré que des éléments non explorés comme la présence d’embol

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Eleutério, Ricardo Jorge Neves. "Microwave imaging of the axilla to aid breast cancer diagnosis." Master's thesis, 2014. http://hdl.handle.net/10362/13658.

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Breast cancer is the most common type of cancer among women all over the world. An important issue that is not commonly addressed in breast cancer imaging literature is the importance of imaging the underarm region—where up to 80% of breast cancer cells can metastasise to. The first axillary lymph nodes to receive drainage from the primary tumour in the breast are called Sentinel Node. If cancer cells are found in the Sentinel Node, there is an increased risk of metastatic breast cancer which makes this evaluation crucial to decide what follow-up exams and therapy to follow. However, non-inva

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Louis, Kristine Sarah. "Characterization of ZHX1 in Axillary Lymph Node-negative Breast Cancer." Thesis, 2012. http://hdl.handle.net/1807/32603.

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Women with breast cancer without local metastasis to the axillary lymph nodes (axillary lymph node-negative, ANN) have a good prognosis. However, 20 to 30% of patients with ANN breast cancer will still experience recurrence and distant metastases. Lymphatic invasion (LVI) is an important prognostic factor for ANN breast cancer. Zinc fingers and homeoboxes 1 (ZHX1) was identified as a candidate gene involved in LVI and associated with early recurrence of ANN breast cancer. I examined expression of ZHX1 in breast cancer cell lines and ANN breast tumour samples and discovered that it is expressed

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Wells, Bryan John. "A Comparison of the Costs of Sentinel Lymph Node Biopsy and of Axillary lymph Node Dissection in the Management of Early-stage Breast Cancer in Ontario." Thesis, 2009. http://hdl.handle.net/1807/18993.

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Objective: To complete a cost-minimization analysis (CMA) of the cost of sentinel lymph node biopsy (SLNB) and axillary lymph node dissection (ALND) in the management of early-stage breast cancer (ESBC) in a hypothetical Ontario hospital setting. Methods: Decision-analysis modeling, with a decision-tree and Markov states, was used to estimate hospital costs for the two treatment options. The model was populated with data from the literature and costs from the Ontario Case Costing Initiative, a publicly accessible, government-sponsored, costing database. Model variability and parameter uncert

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Hung, Chin-Sheng, and 洪進昇. "High expression of CXCR4 in HER2 negative breast cancer patient may contribute to lymph node metastasis." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/70078996122203709811.

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碩士<br>國立臺灣大學<br>臨床醫學研究所<br>96<br>Purposes of the study: Lymph node metastasis is an important prognostic factor in breast cancer, and lymph node metastasis may be the initial step for further distal metastasis. Therefore, identifying the contributing factors of lymph node metastasis in breast cancer may be helpful to understand the mechanism of metastasis. CXC chemokine receptor 4（CXCR4）is a member of chemokine receptor which is mostly expressed in immune cells. However, many studies report the expression in cancer cell and the relationship between cancer metastasis and CXCR4 expression. So, o

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Mathe, Andrea. "Genetic and epigenetic changes associated with the development of lymph node metastasis in triple negative breast cancer." Thesis, 2016. http://hdl.handle.net/1959.13/1314568.

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Research Doctorate - Doctor of Philosophy (PhD)<br>Breast cancer is the most common cancer in women worldwide with one of the highest cancer-related death rates. The most aggressive breast cancer subtype is triple negative breast cancer (TNBC), which is characterised by the lack of expression for the estrogen receptor, progesterone receptor, and human epidermal growth factor 2. These receptors provide treatment targets in other breast cancer subtypes, which express at least one of these. Not only is there no targeted therapy for TNBC, it is also known to metastasise more frequently and earlier

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Li, Karen Hui. "Micrometastatic node-positive breast cancer: an analysis of survival outcomes and prognostic impact of the number of positive nodes and the ratio of positive to excised nodes in comparison to node-negative and macrometastatic node-positive breast cancer." Thesis, 2009. http://hdl.handle.net/1828/1393.

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In this study, we examined survival for patients with micrometastases greater than 0.2mm but less than 2mm (pN1a) in comparison to node-negative (pN0) and macrometastatic node-positive (pN1b) patients. Data for patients diagnosed from 1988 to 1998 with TNM pathological T1-2 stage, pN0, and pN1a-b breast cancer with no distant metastasis was provided by Dr. P. Truong from BC Cancer Agency. Results obtained from the Kaplan-Meier estimators and the multivariable Cox Proportional Hazards Model analyses suggested that micrometastatic node-positive patients had worse survival than the node-negative

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Murch, Lisa Elaine. "Evaluation of pathologic parameters and published nomograms in predicting non-sentinel lymph node metastases in female breast cancer patients with positive sentinel lymph nodes." 2007. http://hdl.handle.net/1993/21219.

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Klein, Evelyn [Verfasser]. "Evaluation of side effects after axillary lymph node dissection for breast cancer taking tumour staging status into account / Evelyn Klein." 2009. http://d-nb.info/1006965459/34.

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Rempp, Hansjörg [Verfasser]. "Sentinel lymph-node radiodetection in breast cancer : results of a clinical study and development of a quantitative approach / vorgelegt von Hansjörg Rempp." 2005. http://d-nb.info/977655350/34.

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Chu, Hou-Wei, and 禇候維. "A Novel Estrogen Receptor-microRNA 190a-PAR-1-Pathway Regulates Breast Cancer Progression, A Finding Initially Suggested by Genome-Wide Analysis of Loci Associated with Lymph-Node Metastasis." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/45156246177806729968.

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博士<br>國防醫學院<br>生命科學研究所<br>102<br>To identify microRNAs that are important in regulating breast cancer progression, the present study used data for the 199961 single-nucleotide polymorphisms (SNPs) in 837 breast cancer patients genotyped in a recent genome-wide association study to identify loci associated with lymph node metastasis (LNM). SNPs tagging the 15q22.2 locus showed a significant association with LNM and miR-190a was found to be the only microRNA in this region. The role of miR-190a in LNM was supported by the findings that increased miR-190a expression inhibited cell migration and i

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Kolařík, Dušan. "Populace buněk karcinomu prsu. Využití pro stanovení optimálního terapeutického postupu. Prediktivní model." Doctoral thesis, 2016. http://www.nusl.cz/ntk/nusl-351520.

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1 ABSTRACT Background Breast cancer cell population characteristics are used in common clinical practice for estimation of prognosis of the malignant disease (prognostic factors) and for prediction of reactivity of the tumor to certain therapeutic modality (predictive factors). Also axillary lymph node status is an independent prognostic factor in women with early breast cancer. Therefore, surgical excision and following histopathological examination of the nodes is the obligatory part of primary breast cancer surgery. The extension of axillary surgery varies widely, although sentinel lymph no

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Dostálek, Lukáš. "Možnosti značení lymfatických uzlin v axile u pacientek s karcinomem prsu." Doctoral thesis, 2021. http://www.nusl.cz/ntk/nusl-446960.

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Introduction Axillary dissection has little diagnostic and therapeutic benefit in the node-positive breast cancer patients in whom axillary disease has been completely eradicated after neoadjuvant chemotherapy (ypN0). We sought to assess the efficacy of an algorithm used for the identification of the ypN0 patients consisting of intraoperative evaluation of sentinel and tattooed (initially positive) lymph nodes. Methods Included were T1 and T2 breast cancer patients with one to three positive axillary lymph nodes marked with carbon who were referred for neoadjuvant chemotherapy followed by a su

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Duarte, Nuno Miguel de Faria Bento. "Fisioterapia: influência na qualidade de vida da mulher com cancro da mama: contributo para a qualidade do serviço em oncologia." Doctoral thesis, 2016. http://hdl.handle.net/10362/20113.

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RESUMO - Introdução: As modalidades da cirurgia a cancro da mama que recorrem apenas à biópsia do gânglio sentinela (BGS) têm um menor impacto na qualidade de vida (QdV) das mulheres quando comparadas às cirurgias em que é realizada uma linfadenectomia axilar. No entanto, na fase aguda de sobrevivência, na qual são realizados tratamentos por terapias oncológicas ao longo do primeiro ano após o diagnóstico, o efeito dessas terapias poderá sobrepor-se à menor agressividade da cirurgia com BGS, levando a que não existam diferenças na QdV destes dois grupos de doentes. Existe alguma evidênci

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Mechtouf, Nawel. "Détection moléculaire des métastases des ganglions lymphatique dans le cancer du col de l'utérus." Thèse, 2014. http://hdl.handle.net/1866/12768.

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Le Cancer du Col Utérin (CCU) chez la femme est provoqué par le virus oncogénique VPH. La métastase lymphatique ganglionnaire est un facteur pronostique majeur pour l’évolution de ce cancer et sa présence influence la décision thérapeutique. En général, l’envahissement ganglionnaire est diagnostiqué par histologie, mais cette méthode est laborieuse et parfois prise en défaut pour détecter les micrométastases et les cellules cancéreuses isolées et pour donner des résultats rapides en per opératoire. L’outil moléculaire que nous désirons développer pour combler cette lacune est basé sur une anal

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Hashim, Che Gon. "Identifying predictors of postoperative persistent pain in women with breast cancer: assessments of investigative tools." Master's thesis, 2018. http://hdl.handle.net/1885/162744.

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Persistent pain after surgery in breast cancer has a significant impact on the patient’s survival. The value of escalating research on breast cancer in Malaysia cannot be underestimated. However, it is not known how many of these women experience persistent pain after surgery. This study surveyed previously unknown figures on prevalence, and explored the predictive factors of persistent pain women with breast cancer in Malaysia. There were three objectives. First, to assess the reliability of the already established investigative tools, namely, the Brief

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Kocián, Roman. "Význam biopsie sentinelové uzliny v léčbě pacientek s časným stádiem karcinomu děložního hrdla." Doctoral thesis, 2021. http://www.nusl.cz/ntk/nusl-447348.

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The sentinel lymph node biopsy is part of recommended surgical staging guidelines in patients with early stages of cervical cancer. High success rates of bilateral detection of SLN are achieved in sites with adequate experience with this procedure. The sentinel lymph node biopsy without systematic pelvic lymph node dissection is currently considered inadequate procedure for stages IB to IIA of the disease. One of the benefits of sentinel lymph node detection is extensive histopathological examination using the ultrastaging protocol enabling detection of small metastases (i.e. micrometastases).

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