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Journal articles on the topic 'Lymph node;breast cancer;detection'

Author: Grafiati

Published: 4 June 2021

Last updated: 21 February 2023

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1

Nikitenko, R., V. Kosovan, K. Vorotyntseva, and E. Koichev. "The role of sentinel lymph nodes in breast cancer." Journal of Education, Health and Sport 12, no. 6 (2022): 365–76. http://dx.doi.org/10.12775/jehs.2022.12.06.037.

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Introduction. The problem of improving early diagnosis and prognosis of breast cancer remains one of the most actual for current oncological practice. Taking into account a close correlation between the general prevalence of breast neoplasms and mortality from breast cancer, this problem is not only of professional interest, but also has medical-social and socio-economic significance. The purpose of the study is to improve the quality of the sentinel lymph node detection in patients with breast cancer using ICG. Material and methods. At the period 2009–2016, 400 patients with T1-T3

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Lee, S., J. Yang, S. Nam, et al. "Triple detection method for sentinel lymph node detection." Journal of Clinical Oncology 27, no. 15_suppl (2009): e11605-e11605. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.e11605.

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e11605 Background: Sentinel lymph node biopsy is widely accepted method to determine nodal stage of breast cancer. There are several reported method for detecting sentinel lymph node. The aim of this study was to show the new detection method of sentinel lymph node and show the effectiveness of this method. Methods: We did prospective study and enrolled 25 patients who underwent partial mastectomy and sentinel lymph node biopsy. We injected indigocyanine green (green dye) at peritumoral lesion, indigocarmine dye (blue dye) in subareolar area and radioisotope (Tc-99m) injection. Sentinel lymph

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Coibion, Michel, Fabrice Olivier, Audrey Courtois, Nathalie Maes, Véronique Jossa, and Guy Jerusalem. "A Randomized Prospective Non-Inferiority Trial of Sentinel Lymph Node Biopsy in Early Breast Cancer: Blue Dye Compared with Indocyanine Green Fluorescence Tracer." Cancers 14, no. 4 (2022): 888. http://dx.doi.org/10.3390/cancers14040888.

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Background: Indocyanine green (ICG) is a promising tracer for sentinel lymph node biopsy in early breast cancer. This randomized study was conducted to evaluate sentinel lymph node biopsy with ICG compared with blue dye as a tracer in woman with early breast cancer without any sign of lymph node invasion. Methods: Between January 2019 and November 2020, 240 consecutive women with early breast cancer were enrolled and randomized to sentinel lymph node biopsy using ICG or blue dye. The primary endpoint was the sentinel lymph node detection rate in both arms. Results: ICG was used in 121 patients

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Portnoy, Sergey, A. Kuznetsov, N. Shakirova, et al. "SENTINEL LYMPH NODE BIOPSY USING FLUORESCENT LYMPHOGRAPHY IN CT1-4N0M0 BREAST CANCER PATIENTS: HIGH DIAGNOSTIC CAPABILITIES." Problems in oncology 65, no. 2 (2019): 243–49. http://dx.doi.org/10.37469/0507-3758-2019-65-2-243-249.

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Breast cancer cT1-4N0M0 patients usually require a sentinel lymph node biopsy. Sentinel lymph node biopsy with indocyanine green fluorescence detection is a modern technique with a high lymph node detection rate. However, the false-negative rate was not evaluated adequately. Our objective was to determine node detection rate and the false-negative rate. 99 patients with 100 cases of breast cancer cT1-4N0M0 were operated on. The axillary part of an operation consisted of indocyanine green fluorescence-guided SLN biopsy and an axillary lymphadenectomy of levels I-II or I-П-Ш. A signal lymph node

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Song, B., J. Bae, J. Kim, H. Jeon, and S. Jung. "Comparing study of positron emission tomography and ultrasonography in the detection of axillary lymph node metastasis in patients with early stage breast cancer." Journal of Clinical Oncology 25, no. 18_suppl (2007): 616. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.616.

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616 Background: The current status of axillary lymph node is the most important prognostic factor in breast cancer. Axillary lymph node dissection (ALND) is currently the standard option for assessment of axillary lymph nodes. Positron emission tomography - computerized tomography (PET-CT) imaging and breast sonography are a noninvasive imaging modality that can detect malignant lymph node. The purpose of this study was to evaluate the clinical usefulness of axillary lymph node staging by means of PET-CT imaging compare with breast sonography in breast cancer. Methods: This study involves 129

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Mátrai, Zoltán, László Tóth, Toshiaki Saeki, et al. "The potential role of SPECT/CT in the preoperative detection of sentinel lymph nodes in breast cancer." Orvosi Hetilap 152, no. 17 (2011): 678–88. http://dx.doi.org/10.1556/oh.2011.29077.

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Regional lymph node status is the most important prognostic factor in breast cancer. Sentinel lymph node biopsy is the standard method of axillary staging in early breast cancer patients with clinically negative nodes. Preoperative lymphoscintigraphy might support refining biopsy findings by determining the number and location of sentinel lymph nodes. In aged or overweight patients, in the presence of atypical or extra-axillary lymphatic drainage, non-visualized lymph nodes, or sentinel lymph nodes close to the isotope injection site, detection could be aided by a new, hybrid imaging tool: the

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Huang, Yihong, Shuo Zheng, and Baoyong Lai. "Analysis of the Mechanism of Breast Metastasis Based on Image Recognition and Ultrasound Diagnosis." Journal of Healthcare Engineering 2021 (October 11, 2021): 1–11. http://dx.doi.org/10.1155/2021/4452500.

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Breast cancer is one of the cancers with the highest incidence among women. In the late stage, cancer cells may metastasize to a distance, causing multiple organ diseases, threatening the lives of patients. The detection of lymph node metastasis based on pathological images is a key indicator for the diagnosis and staging of breast cancer, and correct staging decisions are the prerequisite and basis for targeted treatment. At present, the detection of lymph node metastasis mainly relies on manual screening by pathologists, which is time-consuming and labor-intensive, and the diagnosis results

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Liu, Pengcheng, Jie Tan, Yuting Song, Kai Huang, Qingyi Zhang, and Huiqi Xie. "The Application of Magnetic Nanoparticles for Sentinel Lymph Node Detection in Clinically Node-Negative Breast Cancer Patients: A Systemic Review and Meta-Analysis." Cancers 14, no. 20 (2022): 5034. http://dx.doi.org/10.3390/cancers14205034.

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Superparamagnetic iron oxide (SPIO), an alternative mapping agent, can be used to identify sentinel lymph nodes in patients with clinically node-negative breast cancer. However, its performance in comparison with the standard method, using a radioisotope (technetium-99 m, Tc) alone or in combination with blue dye, remains controversial. Hence, a systematic review and meta-analysis were conducted to evaluate the diagnostic accuracy of SPIO and its clinical impact in the management of breast cancer. The PubMed, Embase, and Cochrane databases were comprehensively searched from inception to 1 May

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Euscher, Elizabeth. "Pathology of sentinel lymph nodes: historical perspective and current applications in gynecologic cancer." International Journal of Gynecologic Cancer 30, no. 3 (2020): 394–401. http://dx.doi.org/10.1136/ijgc-2019-001022.

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Efforts to reduce surgical morbidity related to en bloc lymph node removal associated with cancer surgery led to the development of targeted lymph node sampling to identify the lymph node(s) most likely to harbor a metastasis. Through identification of one or only a few lymph nodes at highest risk, the overall number of lymph nodes removed could be markedly reduced. Submission of fewer lymph nodes affords more detailed pathologic examination than would otherwise be practical with a standard lymph node dissection. Such enhanced pathologic examination techniques (ie, ultra-staging) have contribu

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Pelosi, E., V. Arena, B. Baudino, et al. "Sentinel Node Detection in Breast Carcinoma." Tumori Journal 88, no. 3 (2002): S10—S11. http://dx.doi.org/10.1177/030089160208800323.

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Aims and Background The standard procedure for the evaluation of axillary nodal involvement in patients with breast cancer is still complete lymph node dissection. However, about 70% of patients are found to be free of metastatic disease while axillary node dissection may cause significant morbidity. Lymphatic mapping and sentinel lymph node (SLN) biopsy are changing this situation. Methods and Study Design In a period of 18 months we studied 201 patients with breast cancer, excluding patients with palpable axillary nodes, tumors >2.5 cm in diameter, multifocal or multicentric cancer, pregn

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Vatankha, S. S., and F. Yu Aliev. "First experience of lymphoscintigraphy use in early stages of breast cancer." Kazan medical journal 98, no. 2 (2017): 293–95. http://dx.doi.org/10.17750/kmj2017-293.

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Aim. To evaluate efficacy of radioisotopic methods in detection of metastatic involvement of sentinel lymph nodes for choosing further theurapeutic tactics.  Methods. The study group included 23 females with confirmed breast cancer. Sentinel lymph nodes were detected by isotope 99mTc Nanocolloid and blue dye in General Electric gamma camera (USA).  Results. In all cases patients’ age was 45 to 60 years. In 16 (69.5%) cases the tumor size was below 5 cm which corresponded to clinical stage 2, in other 7 (30.5%) patients the tumor size was below 2 cm. Positive results with the use of

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Scharl, Anton J., and Andreas Düran. "Where to look for sentinel node in breast cancer?" Journal of Clinical Oncology 30, no. 15_suppl (2012): 2560. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.2560.

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2560 Background: It has been observed, that the caudal Axilla on the border to pectoralis muscle is predicive for the sentinel node. The sono-morphology of lymph nodes has been the subject of multiple publications, usually dealing with malignant melanoma. In the context of sentinel lymph node biopsy (SLNB) in breast cancer patients, the following study examines the feasibility of the sonographic differentiation of the Sentinel lymph node (SLN) from neighboring non-SLNs and whether sentinel-ultrasound-needle localization (SUN) is a useful addition or alternative to current methods of “lymphatic

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Vogt, H., R. Bares, W. Brenner, et al. "Verfahrensanweisung für die nuklear medizinische Wächter-Lymphknoten-Diagnostik." Nuklearmedizin 49, no. 04 (2010): 167–72. http://dx.doi.org/10.3413/nukmed-321.

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SummaryThe authors present a procedure guideline for scintigraphic detection of sentinel lymph nodes in malignant melanoma and other skin tumours, in breast cancer, in head and neck cancer, and in prostate and penile carcinoma. Important goals of sentinel lymph node scintigraphy comprise reduction of the extent of surgery, lower postoperative morbidity and optimization of histopathological examination focussing on relevant lymph nodes. Sentinel lymph node scintigraphy itself does not diagnose tumorous lymph node involvement and is not indicated when lymph node metastases have been definitely d

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Gerber, Bernd, Annette Krause, Heiner Müller, et al. "Simultaneous Immunohistochemical Detection of Tumor Cells in Lymph Nodes and Bone Marrow Aspirates in Breast Cancer and Its Correlation With Other Prognostic Factors." Journal of Clinical Oncology 19, no. 4 (2001): 960–71. http://dx.doi.org/10.1200/jco.2001.19.4.960.

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PURPOSE: We studied the prognostic and predictive value of immunohistochemically detected occult tumor cells (OTCs) in lymph nodes and bone marrow aspirates obtained from node-negative breast cancer patients. All were classified as distant metastases-free using conventional staging methods. PATIENTS AND METHODS: A total of 484 patients with pT1-2N0M0 breast cancer and 70 with pT1-2N1M0 breast cancer and a single affected lymph node participated in our trial. Ipsilateral axillary lymph nodes and intraoperatively aspirated bone marrow were examined. All samples were examined for OTCs using monoc

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Jean Pierre, M., J. Extra, J. Jacquemier, et al. "Sentinel lymphadenectomy for the staging of clinical axillary node-negative breast cancer before neoadjuvant chemotherapy." Journal of Clinical Oncology 27, no. 15_suppl (2009): e11575-e11575. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.e11575.

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e11575 Background: Several authors reported sentinel lymph node biopsy after neoadjuvant chemotherapy. Nevertheless, the ideal time of sentinel lymph node biopsy is still a matter of debate. Methods: We evaluated the feasibility and the accuracy of sentinel lymph node biopsy before neoadjuvant chemotherapy using a combined procedure (blue dye and radio-labelled detection) in a homogeneous cohort study with clinically axillary node-negative breast cancer. Study candidates were patients referred to the Institut Paoli-Calmettes Cancer Center (Marseille, France) for the treatment of invasive breas

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Menard, J., J. Extra, J. Jacquemier, et al. "Sentinel lymphadenectomy for the staging of clinical axillary node-negative breast cancer before neoadjuvant chemotherapy." Journal of Clinical Oncology 27, no. 15_suppl (2009): e11604-e11604. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.e11604.

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e11604 Background: Several authors reported sentinel lymph node biopsy after neoadjuvant chemotherapy. Nevertheless, the ideal time of sentinel lymph node biopsy is still a matter of debate. Methods: We evaluated the feasibility and the accuracy of sentinel lymph node biopsy before neoadjuvant chemotherapy using a combined procedure (blue dye and radio-labelled detection) in a homogeneous cohort study with clinically axillary node-negative breast cancer. Study candidates were patients referred to the Institut Paoli-Calmettes Cancer Center (Marseille, France) for the treatment of invasive breas

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Bozhok, A. A., O. N. Tsarev, S. A. Maysuradze, and A. I. Gil. "Questions of axillary region surgery in breast cancer patients after systemic neoadjuvant therapy." Tumors of female reproductive system 17, no. 4 (2022): 56–65. http://dx.doi.org/10.17650/1994-4098-2021-17-4-56-65.

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As a consequence of the advances in systemic neoadjuvant therapy of breast cancer is the de-escalation of surgical treatment. The study of a limited number of axillary lymph nodes after neoadjuvant therapy and refusal of lymphadenectomy in the absence of metastatic lesions is becoming more common. The published studies have proven the informativeness and safety of standard techniques of sentinel lymph node biopsy after neoadjuvant treatment for cN0 patients. For group cN1 and regression of metastases after neoadjuvant treatment, standard sentinel lymph node biopsy techniques have failed. The u

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Pargaonkar, Anjali S., Robert S. Beissner, Samuel Snyder, and V. O. Speights. "Evaluation of Immunohistochemistry and Multiple-Level Sectioning in Sentinel Lymph Nodes From Patients With Breast Cancer." Archives of Pathology & Laboratory Medicine 127, no. 6 (2003): 701–5. http://dx.doi.org/10.5858/2003-127-701-eoiams.

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Abstract Context.—Previous investigations on sentinel lymph node biopsies have demonstrated their importance in nodal staging of patients with breast cancer. However, sentinel node biopsy in breast cancer is currently a controversial procedure and continues to provoke debate. Objectives.—We designed our study to determine the usefulness of a standard protocol for evaluating sentinel lymph node metastases and to assess the value of sentinel node biopsy as the only procedure in nodal staging in breast cancer patients. Materials and Methods.—A retrospective analysis of 84 breast cancer patients w

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Sakorafas, George H., and Adelais G. Tsiotou. "Sentinel Lymph Node Biopsy in Breast Cancer." American Surgeon 66, no. 7 (2000): 667–74. http://dx.doi.org/10.1177/000313480006600713.

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One of the most important prognostic indicators in patients with breast cancer is axillary lymph node status. Sentinel lymph node (SLN) biopsy has emerged as a potential alternative to routine axillary dissection in clinically node-negative early breast cancer. This procedure requires a specialized but multidisciplinary approach utilizing the surgeon, nuclear radiologist and pathologist. SLN biopsy allows adequate assessment of the axillary nodal status in patients with early breast cancer, with minimal—if any—morbidity. Blue dye and lymphoscintigraphy are complementary techniques, and the suc

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Schem, C., N. Maass, D. O. Bauerschlag, et al. "One Step Nucleic Acid Amplification (OSNA) for intra-operative detection of lymph node metastases in breast cancer patients." Journal of Clinical Oncology 25, no. 18_suppl (2007): 21053. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.21053.

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21053 Background: Sentinel lymph node metastasis in breast cancer patients has conventionally been determined by intra- operative histopathological examination of frozen sections followed by definitive post-operative examination of permanent sections. The purpose of this study is to evaluate a more efficient method for intra-operative detection of lymph node metastasis in a clinical setting. Therefore, a new rapid method of detection of CK19 mRNA by One Step Nucleic Acid Amplification (OSNA) and Reverse Transcription Loop Mediated Isothermal Amplification (RT-LAMP) was tested against standard

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Bembenek, Reuhl, Markwardt, Schneider, and Schlag. "Sentinel Lymph Node Dissection in Breast Cancer." Swiss Surgery 5, no. 5 (1999): 217–21. http://dx.doi.org/10.1024/1023-9332.5.5.217.

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During the last years, the efficacy and reliability of the sentinel lymph node biopsy (snb) as a minimal invasive diagnostic procedure for the nodal status has been intensively evaluated. After the widespread clinical use in the staging of melanoma patients the snb is currently introduced in the clinical management of breast cancer patients. We present our experience with this method during 3,5 years and discuss its potential and pitfalls. From 11/95 to 3/99 we performed sentinel node detection in 146 patients with breast cancer stage I to III, consisting of 127 patients with pT1/2-tumors and

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Sharma, Sunita, and C. S. Mohanty. "Detection of Micrometasteses In Lymph Nodes in Cases of Carcinoma Breast by Immunohistochemistry." Annals of Pathology and Laboratory Medicine 7, no. 8 (2020): A400–408. http://dx.doi.org/10.21276/apalm.2745.

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Background – We evaluated archived lymph nodes of breast carcinoma for micrometastases detection by serial multiple sections (SMS) and immunohistochemistry (IHC) and found increased positive lymph nodes yield which led to change in staging in few cases, treatment and prognosis. Method – Metastatic free, early breast cancer cases of 36 patients with lymph node status pN0 or pN1 were evaluated. These were the cases had been treated with modified radicle mastectomy and axillary lymph node dissection. All the lymph node was cut at 50µm interval to get 5µm thick serial sections. These serial

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Bara, Tivadar, Tivadar Bara, Radu Neagoe, et al. "Sentinel Lymph Node Mapping In Gastric Cancer Surgery: Current Status." Acta Medica Marisiensis 62, no. 4 (2016): 403–7. http://dx.doi.org/10.1515/amma-2016-0047.

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AbstractLymphonodular metastases remain an important predictive and prognostic factor in gastric cancer development. The precise determination of the lymphonodular invasion stage can be made only by extended intraoperative lymphadenectomy and histopathological examination. But the main controversy is the usefulness of extended lymph dissection in early gastric cancer. This increases the duration of the surgery and the complications rate, and it is unnecessary without lymphonodular invasion. The identification of the sentinel lymph nodes has been successfully applied for some time in the precis

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Hartmann, Steffi, Angrit Stachs, Thorsten Kühn, Jana de Boniface, Maggie Banys-Paluchowski, and Toralf Reimer. "Targeted Removal of Axillary Lymph Nodes After Carbon Marking in Patients with Breast Cancer Treated with Primary Chemotherapy." Geburtshilfe und Frauenheilkunde 81, no. 10 (2021): 1121–27. http://dx.doi.org/10.1055/a-1471-4234.

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AbstractIn breast cancer patients who have received primary chemotherapy and then no longer have any suspicious lymph nodes clinically and/or on imaging, marking of initially suspicious axillary lymph nodes with targeted removal has recently been discussed and practised both in Germany and internationally as an alternative to complete axillary lymph node dissection. Tattooing of the suspicious lymph nodes with a highly purified carbon suspension is currently being investigated in clinical studies. Compared with other techniques, the advantages of this method are the high rate of intraoperative

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Yang, Benlong, Dechuang Jiao, Jiajian Chen, et al. "Abstract P1-01-10: A phase 3, multicenter, self-controlled, non-inferiority trial comparing mitoxantrone hydrochloride injection for tracing versus technetium-99m in the detection of axillary sentinel nodes in patients with early-stage breast cancer." Cancer Research 82, no. 4_Supplement (2022): P1–01–10—P1–01–10. http://dx.doi.org/10.1158/1538-7445.sabcs21-p1-01-10.

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Abstract Aim:Mitoxantrone is an antineoplastic antibiotic used in the treatment of acute leukemia, lymphoma, prostate and breast cancer. Mitoxantrone Hydrochloride Injection for tracing has a high degree of lymph node tropism by changing the dosage form, which penetrates into lymphatic capillaries through the interstitial space and enriches regional lymph nodes through the gland to stain the lymph nodes blue to achieve lymph node tracing effect. This study is aim to evaluate the efficacy and safety of Mitoxantrone Hydrochloride injection(MHI) for tracing sentinel lymph nodes in patients with e

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Masood, S. "Micrometastasis in lymph node." Breast Cancer Online 9, no. 5 (2006): 1–3. http://dx.doi.org/10.1017/s1470903105003342.

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Determining whether cancer has spread to the lymph nodes is important in predicting survival from breast cancer and determining what treatment a patient requires. The traditional method of detecting such metastases, complete axillary node dissection, can result in lymphedema and other quality-of-life damaging side effects. The new technique of sentinel lymph node biopsy (SLNB) offers a way to test for lymph node metastases without causing the side effects of traditional axillary node dissection. Intraoperative analysis of SLNB is becoming an effective tool in assessment of the presence or abse

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Singh, Rohit, Bhavinder Kumar Arora, Vijay Pal, Gourav Mittal, and Monika Shekhawat. "Role of magnetic resonance imaging in detection of metastatic axillary lymph nodes in breast cancer patients." International Surgery Journal 9, no. 5 (2022): 1046. http://dx.doi.org/10.18203/2349-2902.isj20221153.

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Background: Magnetic resonance imaging has been evolved as a very important tool in diagnosing the axillary lymph nodes pre-operatively. In recent studies, in women with various risk profiles, the sensitivity ranges between 81% and 100%, which is approximately twice as high as the sensitivity of mammography. Methods: This prospective study was performed at PGIMS, Haryana from December 2018 to March 2020. Total 30 patients (n=30) were included in the study. All the patients presenting with clinically palpable breast lump, underwent triple assessment test. All the patient underwent modified radi

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Singh, Rohit, Bhavinder Kumar Arora, Vijay Pal, Gourav Mittal, and Monika Shekhawat. "Role of magnetic resonance imaging in detection of metastatic axillary lymph nodes in breast cancer patients." International Surgery Journal 9, no. 5 (2022): 1046. http://dx.doi.org/10.18203/2349-2902.isj20221153.

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Background: Magnetic resonance imaging has been evolved as a very important tool in diagnosing the axillary lymph nodes pre-operatively. In recent studies, in women with various risk profiles, the sensitivity ranges between 81% and 100%, which is approximately twice as high as the sensitivity of mammography. Methods: This prospective study was performed at PGIMS, Haryana from December 2018 to March 2020. Total 30 patients (n=30) were included in the study. All the patients presenting with clinically palpable breast lump, underwent triple assessment test. All the patient underwent modified radi

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Abreu, Benedita Andrade Leal de, Adriana de Morais Santos, Lívia de Almeida Soares, et al. "Sentinel lymph node detection through radioguided surgery in patients with breast cancer." Brazilian Archives of Biology and Technology 51, spe (2008): 57–61. http://dx.doi.org/10.1590/s1516-89132008000700010.

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Biopsy of the sentinel lymphnode (SLNB), the first lymphnode to receive lymphatic drainage from the primary tumor, accurately predicts the axillary lymph node status and, when negative, obviates the need for axillary lymphadenectomy (AL). The aim of this study was, to verify the SLN localization in breast cancer through preoperative lymphoscintigraphy and intraoperative gamma-probe, as well as to demonstrate the benefits of such techniques in preventing complications of AL. Medical records of 228 patients with breast carcinoma, who were underwent SLN localization and, radioguided surgery, from

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Pizzocaro, Claudio, Pier Luigi Rossini, Arturo Terzi, et al. "Sentinel Node Biopsy in Breast Cancer: The Experience of Brescia Civic Hospital." Tumori Journal 86, no. 4 (2000): 309–11. http://dx.doi.org/10.1177/030089160008600412.

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The accuracy of the sentinel node technique in the evaluation of axillary node involvement in breast cancer was evaluated in 83 consecutive patients with monofocal T1–2 carcinoma, who were clinically N0 and who underwent lymphoscintigraphy with 99mTc-colloid integrated with intraoperative sentinel node detection by a portable probe. Lymphoscintigraphy revealed at least one sentinel node in 75 patients (90.4%), always identified by the probe. In eight patients (9.6%) the sentinel node was detected neither by lymphoscintigraphy nor by the probe. All removed lymph nodes were analyzed by hematoxyl

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Milulescu, Amelia, Cristian Gabriel Viisoreanu, Nicolae Bacalbasa, et al. "Management of the axilla: Conventional tracers vs ICG-fluorescence in sentinel lymph node biopsy." Romanian Medical Journal 68, S6 (2021): 126–28. http://dx.doi.org/10.37897/rmj.2021.s6.21.

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The evaluation of regional lymph nodes is part of breast cancer staging. Biopsy of the sentinel lymph node was established, in order to evaluate the condition of the axillary lymph nodes without having to complete an axillary dissection. The concept of sentinel lymph node (SLN) is based on the theory of sequential dissemination of tumor cells through the lymph. When lymphatic dissemination occurs, the invasion initially occurs in the first lymph node that drains lymph from the tumor. This lymph node has been named GS and depending on its negative or positive status, the presence or absence of

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Sahin, Aysegul A., Merih Guray, and Kelly K. Hunt. "Identification and Biologic Significance of Micrometastases in Axillary Lymph Nodes in Patients With Invasive Breast Cancer." Archives of Pathology & Laboratory Medicine 133, no. 6 (2009): 869–78. http://dx.doi.org/10.5858/133.6.869.

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Abstract Context.—The presence or absence of metastases in axillary lymph nodes is one of the most important prognostic factors for patients with breast cancer. During the past decade sentinel lymph node (SLN) biopsy has been increasingly adopted as a minimally invasive staging alternative to complete axillary node dissection. Objective.—Sentinel lymph nodes are more likely to contain metastases than non-SLNs. In routine clinical practice SLNs are assessed by diverse methodologies including multiple sectioning, immunohistochemical staining, and molecular diagnostic tests. Despite the lack of s

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Leong, Stanley P. "Detection of melanoma, breast cancer and head and neck squamous cell cancer sentinel lymph nodes by Tc-99m Tilmanocept (Lymphoseek®)." Clinical & Experimental Metastasis 39, no. 1 (2021): 39–50. http://dx.doi.org/10.1007/s10585-021-10137-4.

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AbstractTechnetium-99m-labeled Tilmanocept or Lymphoseek® (Cardinal Health, Dublin, Ohio) is a soluble, synthetic molecule with a small diameter (7 nm), which is comprised of technetium-99m chelated to a dextran backbone containing multiple units of mannose ligands with a high affinity for CD206, a receptor located on the surface of macrophages and dendritic cells that are found in high concentration in lymph nodes. It enables quick transit from the injection site and rapid lymph node accumulation. The binding of mannose ligand and CD206 results in the internalization of the ligand and recepto

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Hou, Qiaoyun, Shuohua Chen, Qi An, Boya Li, Yan Fu та Yongzhang Luo. "Extracellular Hsp90α Promotes Tumor Lymphangiogenesis and Lymph Node Metastasis in Breast Cancer". International Journal of Molecular Sciences 22, № 14 (2021): 7747. http://dx.doi.org/10.3390/ijms22147747.

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Early detection and discovery of new therapeutic targets are urgently needed to improve the breast cancer treatment outcome. Here we conducted an official clinical trial with cross-validation to corroborate human plasma Hsp90α as a novel breast cancer biomarker. Importantly, similar results were noticed in detecting early-stage breast cancer patients. Additionally, levels of plasma Hsp90α in breast cancer patients were gradually elevated as their clinical stages of regional lymph nodes advanced. In orthotopic breast cancer mouse models, administrating with recombinant Hsp90α protein increased

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Hopkins, L., S. H. Chang, L. J. Kirstein, et al. "Does mammography affect the nodal status at presentation in 40- to 49-year-old breast cancer patients?" Journal of Clinical Oncology 29, no. 27_suppl (2011): 55. http://dx.doi.org/10.1200/jco.2011.29.27_suppl.55.

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55 Background: It has previously been demonstrated that mammographically-detected breast cancers present as earlier stage disease than those detected as a palpable finding. In addition, it is well known that the single most important prognostic indicator in breast cancer is lymph node status. The benefit of screening mammography in women age 40-49 has been questioned recently, and has led to a change in the recommendations by the United States Preventative Services Task Force (USPSTF) to begin screening mammography in the average risk woman at age 50, rather than 40. In this study, we sought t

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Abe, Makoto, Tetsuya Yamada, and Akinobu Nakano. "Prospective Comparison of Intraoperative Touch Imprint Cytology and Frozen Section Histology on Axillary Sentinel Lymph Nodes in Early Breast Cancer Patients." Acta Cytologica 64, no. 5 (2020): 492–97. http://dx.doi.org/10.1159/000508016.

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Introduction: Since the late 1970s, sentinel lymph node biopsy (SLNB) has been used for several solid malignancies to identify lymph node metastases. This procedure is associated with less surgical morbidity than complete lymphadenectomy. Recent evidence suggests that axillary lymphadenectomy is not required for breast sentinel nodes with micrometastases (≤2 mm). Current clinical management of sentinel nodes indicates that only macrometastases (>2 mm) should be detected intraoperatively. In Japan, an intraoperative histopathological frozen section (FS) method is used to identify lymph node

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Somasundaram, S. K., D. W. Chicken, and M. R. S. Keshtgar. "Detection of the sentinel lymph node in breast cancer." British Medical Bulletin 84, no. 1 (2007): 117–31. http://dx.doi.org/10.1093/bmb/ldm032.

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Rasouli, Z., N. Riyahi-Alam, M. Khoobi, et al. "Lymph Node Metastases Detection Using Gd2O3@PCD as Novel Multifunctional Contrast Imaging Agent in Metabolic Magnetic Resonance Molecular Imaging." Contrast Media & Molecular Imaging 2022 (October 12, 2022): 1–11. http://dx.doi.org/10.1155/2022/5425851.

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Axillary lymph node detection is crucial to staging and prognosis of the lymph node metastatic spread in breast cancer. Currently, lymphoscintigraphy and blue dye, as the conventional methods to localize sentinel lymph nodes (SLNs), are invasive and can only be performed during surgery. This study has had a novel hybrid gadolinium oxide nanoparticle coating with Cyclodextrin-based polyester as a high-relaxivity T1 magnetic resonance molecular imaging (MRMI) contrast agent (CA). Twelve female BALB/c mice were randomly divided into three groups of four mice; each group was injected with 4T1 cell

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Zehentner, Barbara K., Davin C. Dillon, Yuqiu Jiang, et al. "Application of a Multigene Reverse Transcription-PCR Assay for Detection of Mammaglobin and Complementary Transcribed Genes in Breast Cancer Lymph Nodes." Clinical Chemistry 48, no. 8 (2002): 1225–31. http://dx.doi.org/10.1093/clinchem/48.8.1225.

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Abstract Background: Mammaglobin mRNA expression is found in 70–80% of primary and metastatic breast tumor biopsies. The potential breast tumor markers B305D, B726P, and γ-aminobutyrate type A receptor π subunit (GABAπ) complement the expression of mammaglobin. Collectively the expression profile of these four genes could be used as a diagnostic and prognostic indicator for breast cancer. Methods: A multigene reverse transcription-PCR (RT-PCR) assay was established to detect the expression of mammaglobin, GABAπ, B305D, and B726P simultaneously. Specific primers and TaqMan® probes were used to

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Sideri, Mario, Concetta De Cicco, Angelo Maggioni, et al. "Detection of Sentinel Nodes by Lymphoscintigraphy and Gamma Probe Guided Surgery in Vulvar Neoplasia." Tumori Journal 86, no. 4 (2000): 359–63. http://dx.doi.org/10.1177/030089160008600431.

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Background Pathologic lymph node status is the most important prognostic factor in vulvar cancer; however, complete inguinofemoral node dissection is associated with significant morbidity. Intraoperative lymphoscintigraphy associated with gamma detecting probe-guided surgery has proved to be reliable in the detection of sentinel node (SN) involvement in melanoma and breast cancer patients. The present study evaluates the feasibility of the surgical identification of inguinal sentinel nodes using lymphoscintigraphy and a gamma detecting probe in patients with early vulvar cancer. Methods Techne

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Ameri, Bita, Riti Kanesa-Thasan, Maysa M. Abu-Khalaf, et al. "Negative predictive value of ipsilateral axillary ultrasound in the pre-operative assessment of invasive breast cancer." Journal of Clinical Oncology 35, no. 15_suppl (2017): e12080-e12080. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.e12080.

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e12080 Objective: To determine if a negative preoperative axillary ultrasound predicts a negative sentinel lymph node biopsy at surgery. Background: Axillary lymph node involvement is an important prognostic indicator in patients with breast cancer. Sentinel lymph node biopsy (SLNB) is currently the gold standard for determining the presence or absence of axillary metastases. Pre-operative axillary ultrasound is often used to evaluate axillary lymph node status prior to surgery and SLNB. Although there are no established guidelines on when preoperative axillary ultrasound is performed, at our

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Vaz, Teresa, Susy Costa, and Bárbara Peleteiro. "Biópsia do Gânglio Sentinela Guiada por Fluorescência no Cancro da Mama: Taxa de Deteção e Performance Diagnóstica." Acta Médica Portuguesa 31, no. 12 (2018): 706. http://dx.doi.org/10.20344/amp.10395.

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Introduction: Sentinel lymph node biopsy is currently the standard surgical procedure for lymph node staging in patients with early stage breast cancer. It is performed using different techniques, such as the injection of vital dyes and / or radioisotopes and, more recently, guided by fluorescence using Indocyanine green. The aim of this study is to assess the detection rate of sentinel lymph node using Indocyanine green in breast cancer patients according to factors related to the patient and the tumor.Material and Methods: Retrospective study of a random sample of patients with breast cancer

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Choudhury, Monisha, Sapna Agrawal, Mukta Pujani, Shaji Thomas, and Meenu Pujani. "Immunohistochemical detection of axillary lymph node micrometastases in node negative breast cancer patients using cytokeratin and epithelial membrane antigen." South Asian Journal of Cancer 04, no. 01 (2015): 028–31. http://dx.doi.org/10.4103/2278-330x.149946.

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Abstract Background and Objective: The study was conducted to detect occult metastases in lymph node negative breast cancer patients using cytokeratin (CK) and epithelial membrane antigen (EMA) immunohistochemistry (IHC) and correlate this with primary tumor size and grade. Materials and Methods: A total of 32 cases including 12 prospective and 20 retrospective cases of axillary lymph node negative breast cancer were studied. CK and EMA IHC were performed to detect micrometastases. Results: Axillary lymph node metastases were detected in 18.75% of previously node negative cases using CK and EM

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Liu, Lucy H., Kalliopi P. Siziopikou, Sheryl Gabram, and Kenneth D. McClatchey. "Evaluation of Axillary Sentinel Lymph Node Biopsy by Immunohistochemistry and Multilevel Sectioning in Patients With Breast Carcinoma." Archives of Pathology & Laboratory Medicine 124, no. 11 (2000): 1670–73. http://dx.doi.org/10.5858/2000-124-1670-eoasln.

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Abstract Background.—Axillary lymph node dissection for evaluation of the presence or absence of metastatic disease is the single most important prognostic factor for patients with newly diagnosed primary breast cancer. Recently, sentinel lymph node (SLN) biopsy is being investigated as an alternative to the evaluation of the entire axilla. We evaluated whether the application of multilevel sectioning and immunohistochemistry in SLNs will increase the accuracy of detection of metastatic deposits. Methods.—Between October 1998 and July 1999, 38 patients with breast carcinoma (25 ductal, 5 lobul

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Luan, Ting, Yongqing Li, Qingwei Wu, et al. "Value of Quantitative SPECT/CT Lymphoscintigraphy in Improving Sentinel Lymph Node Biopsy in Breast Cancer." Breast Journal 2022 (March 28, 2022): 1–9. http://dx.doi.org/10.1155/2022/6483318.

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Background and Objectives. Sentinel lymph node biopsy has been widely accepted as the standard procedure to assess the axillary lymph node status in breast cancer. However, more than 70% of excised sentinel lymph nodes have been found to be healthy. It may lead to unnecessary excisions and increase the incidence of postoperative complications. The aim of this study was to investigate the value of quantitative Tc-99 m sulfur colloid SPECT/CT in avoiding excessive removal of unnecessary sentinel lymph nodes in breast cancer patients. Methods. We retrospectively enrolled breast cancer patients wh

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Chen, Jie, Jiqiao Yang, Tao He, et al. "Adding carbon nanoparticles to dual-tracers for the sentinel node evaluation after neoadjuvant chemotherapy in patients with pretreatment node-positive breast cancers: The TT-SLNB trial." Journal of Clinical Oncology 39, no. 15_suppl (2021): 566. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.566.

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566 Background: This study measures the feasibility and accuracy of sentinel lymph node biopsy (SLNB) with triple-tracers (TT-SLNB) which combines carbon nanoparticles (CNS) with dual tracers of radioisotope and blue dye, hoping to achieve an optimized method of SLNB after neoadjuvant chemotherapy (NAC) in ycN0 breast cancer patients with pretreatment positive axillary lymph nodes. Methods: Clinically node-negative invasive breast cancer patients with pre-NAC positive axillary lymph nodes who received surgeries from November 2020 to January 2021 were included. CNS was injected at the peritumor

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Kanngurn, Samornmas, Siripong Chewatanakornkul, Teerapon Premprapha, and Paramee Thongsuksai. "Comparability of Different Pathologic Protocols in Sentinel Lymph Node Evaluation: An Analysis of Two Step-Sectioning Methods for the Same Patients With Breast Cancer." Archives of Pathology & Laboratory Medicine 133, no. 9 (2009): 1437–40. http://dx.doi.org/10.5858/133.9.1437.

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Abstract Context.—The pathologic protocol for sentinel lymph node evaluation has yet to be standardized. Results from previous studies are troublesome to compare because they have been conducted on different sets of subjects with cancer. Objective.—To compare the detection of sentinel lymph node metastases by using step-sectioning methods at 20-μm and 150-μm intervals for the same patient with primary breast cancer. Design.—A total of 186, initially tumor-negative sentinel lymph nodes from a group of 80 patients with breast cancer were included. For all nodes, each paraffin block was cut seria

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Braun, Stephan, B. Semeni Cevatli, Cyamak Assemi, et al. "Comparative Analysis of Micrometastasis to the Bone Marrow and Lymph Nodes of Node-Negative Breast Cancer Patients Receiving No Adjuvant Therapy." Journal of Clinical Oncology 19, no. 5 (2001): 1468–75. http://dx.doi.org/10.1200/jco.2001.19.5.1468.

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PURPOSE: In node-negative patients, of whom up to 30% will recur within 5 years after diagnosis, markers are still needed that identify patients at high enough risk to warrant further adjuvant treatment. In the present study we analyzed whether a correlation exists between microscopic tumor cell spread to bone marrow and to lymph nodes and attempted to determine which route is clinically more important. PATIENTS AND METHODS: According to a prospective design, bone marrow aspirates and axillary lymph nodes of level I (n = 1,590) from 150 node-negative patients with stage I or II breast cancer w

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Taffurelli, Mario. "Sentinel lymph node biopsy in breast cancer surgery." Reviews in Health Care 2, no. 2 (2011): 101–12. http://dx.doi.org/10.7175/rhc.v2i2.26.

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Axillary lymph node status is one of the most reliable prognostic factors of long-term survival in breast cancer surgery. Metastatic involvement of the axillary lymph nodes is also crucial in the decision making of potentially useful adjuvant treatment. Until the last decade, Axillary Lymph Nodes Dissection (ALND) was performed in order to obtain the regional lymphatic system staging. In case of non-metastatic spread, that kind of surgery was limited only to this purpose; no further oncological benefits were obtained and the patients were exposed to several comorbidities affecting this type of

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Parasuraman, Madhivardhanam, Bhanumati Giridharan, and Vijaylakshmi. "Use of methylene blue for the detection of sentinel lymph node in breast cancer: a systematic review and meta-analysis." International Surgery Journal 5, no. 1 (2017): 1. http://dx.doi.org/10.18203/2349-2902.isj20175879.

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Sentinel lymph node biopsy is the widely acceptable method for the examination of the breast cancer in the patients. This biopsy is considered as the best method for identifying the axillary involvement. Various dyes are used in this biopsy to find the sentinel lymph node. However, methylene blue dye (MBD) is considered to have a low risk of anaphylaxis, be cost effective and widely available.A systematic review and meta-analysis is performed on the utilisation of the methylene blue dye in the sentinel lymph node biopsy in the examination of breast cancer.Eight studies were appropriate for the

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