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Journal articles on the topic 'Lymph node metastases'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Choi, Hee Jun, Jai Min Ryu, Byung Joo Chae, et al. "Is Sentinel Lymph Node Biopsy for Breast Cancer with Cytology-Proven Axillary Metastasis Safe? A Prospective Single-Arm Study." Journal of Clinical Medicine 10, no. 20 (2021): 4754. http://dx.doi.org/10.3390/jcm10204754.

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The purpose of this study was to evaluate pathologic lymph node metastasis in breast cancer with cytology-proven axillary metastasis. This study was designed prospectively. We performed axillary lymph node dissections (ALND) after lymphatic mapping by near-infrared (NIR) fluorescence imaging with Indocyanine Green (ICG). We evaluated 72 breast cancer patients with cytology-proven axillary metastasis by curative surgery at the Samsung Medical Center between May of 2016 and December of 2017. Among the 72 patients with cytology-proven axillary metastasis, 14 of 39 patients (35.9%) with one or two

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Leibold, Tobias, Jinru Shia, Leyo Ruo, et al. "Prognostic Implications of the Distribution of Lymph Node Metastases in Rectal Cancer After Neoadjuvant Chemoradiotherapy." Journal of Clinical Oncology 26, no. 13 (2008): 2106–11. http://dx.doi.org/10.1200/jco.2007.12.7704.

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Purpose After preoperative chemoradiotherapy of rectal cancer, the number of retrievable and metastatic lymph nodes is decreased. The current TNM classification is based on number and not location of lymph node metastases and may understage disease after chemoradiotherapy. The aim of this study was to examine the prognostic significance of location of involved lymph nodes in rectal cancer patients after preoperative chemoradiotherapy. Patients and Methods We prospectively examined whole-mount specimens from 121 patients with uT3-4 and/or N+ rectal cancer who received preoperative chemoradiothe

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Mabuchi, Seiji, Naoko Komura, Michiko Kodama, Michihide Maeda, Yuri Matsumoto, and Shoji Kamiura. "Significance of the Number and the Location of Metastatic Lymph Nodes in Locally Recurrent or Persistent Cervical Cancer Patients Treated with Salvage Hysterectomy plus Lymphadenectomy." Current Oncology 29, no. 7 (2022): 4856–67. http://dx.doi.org/10.3390/curroncol29070385.

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We retrospectively investigated the significance of metastatic lymph nodes in patients with locally recurrent or persistent cervical cancer in a previously irradiated field and subsequently had salvage hysterectomy. Clinical data were obtained from a chart review, and the prognostic impact of the presence, number (1–2 versus ≥3), and location (pelvic versus pelvic plus para-aortic) of lymph node metastasis was investigated by comparing recurrence and survival. In total, 50 patients were included in this study, of which 21 (42.0%) showed pathological evidence of lymph node metastasis (node-posi

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Munkarah, A. R., A. Jhingran, R. B. Iyer, et al. "Utility of lymphangiography in the prediction of lymph node metastases in patients with cervical cancer." International Journal of Gynecologic Cancer 12, no. 6 (2002): 755–59. http://dx.doi.org/10.1136/ijgc-00009577-200211000-00012.

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Our objective was to assess the value of lymphangiography in selecting patients for surgical staging of locally advanced cervical cancer. We reviewed our computerized database to identify patients with cervical cancer who had abnormal findings on lymphangiography and underwent retroperitoneal lymph node dissection between September 1991 and January 1996. The records of these patients were retrospectively reviewed, and the following data were retrieved: clinical tumor stage and findings on lymphangiography at surgery, and on pathologic examination of resected lymph nodes. The lymphangiograms we

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Li, Jiancheng, and Xiuling Shi. "PS02.131: PATTERN OF LYMPHATIC METASTASIS OF CERVICAL ESOPHAGEAL CANCER." Diseases of the Esophagus 31, Supplement_1 (2018): 158. http://dx.doi.org/10.1093/dote/doy089.ps02.131.

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Abstract Background Cervical esophageal cancer were rarely surgeryed Analysis and discussion of lymph node metastasis of cervical esophageal cancer Methods From July 2008 to June 2017, 10 cases of successful esophagectomy of cervical esophageal cance in our hospital underwent radical resection. Surgical dissection range was the neck and the upper mediastinum. A total of 231 lymph nodes were dissected. The lymph nodes were summarized and grouped in different ways, and analyzed the law of lymph node metastasis. Results 7 cases of esophageal cancer, lymph node metastasis occurred, and the rate of

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Zhou, Hengbo, Pin-ji Lei, and Timothy P. Padera. "Progression of Metastasis through Lymphatic System." Cells 10, no. 3 (2021): 627. http://dx.doi.org/10.3390/cells10030627.

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Lymph nodes are the most common sites of metastasis in cancer patients. Nodal disease status provides great prognostic power, but how lymph node metastases should be treated is under debate. Thus, it is important to understand the mechanisms by which lymph node metastases progress and how they can be targeted to provide therapeutic benefits. In this review, we focus on delineating the process of cancer cell migration to and through lymphatic vessels, survival in draining lymph nodes and further spread to other distant organs. In addition, emerging molecular targets and potential strategies to

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Karachun, Aleksey, Aleksey Belyaev, Yuriy Pelipas, et al. "A LOOK AT THE NAVIGATION SURGERY OF THE GASTRIC CANCER: THE PRESENT STATE OF THE PROBLEM AND OWN EXPERIENCE." Problems in oncology 65, no. 6 (2019): 838–49. http://dx.doi.org/10.37469/0507-3758-2019-65-6-838-849.

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Introduction: Concept of sentinel lymph node biopsy has been discussed during several last decades, because this idea seems perspective in terms of modern minimally invasive and organ-preserving era. However, this method has several limitations including complicated anatomy of gastric lymph nodes distribution and presence of skip-metastases. Materials and methods: 66 Patients with early gastric cancer, intermediate risk of lymph node metastases and technical possibility of ESD were included into our investigation. Patients were assigned to either ESD with sentinel lymph node biopsy (54 patient

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8

Euscher, Elizabeth. "Pathology of sentinel lymph nodes: historical perspective and current applications in gynecologic cancer." International Journal of Gynecologic Cancer 30, no. 3 (2020): 394–401. http://dx.doi.org/10.1136/ijgc-2019-001022.

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Efforts to reduce surgical morbidity related to en bloc lymph node removal associated with cancer surgery led to the development of targeted lymph node sampling to identify the lymph node(s) most likely to harbor a metastasis. Through identification of one or only a few lymph nodes at highest risk, the overall number of lymph nodes removed could be markedly reduced. Submission of fewer lymph nodes affords more detailed pathologic examination than would otherwise be practical with a standard lymph node dissection. Such enhanced pathologic examination techniques (ie, ultra-staging) have contribu

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Mistrangelo, M., A. Mobiglia, B. Mussa, et al. "The Sentinel Node in Anal Carcinoma." Tumori Journal 88, no. 3 (2002): S51—S52. http://dx.doi.org/10.1177/030089160208800344.

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Aims and Background Anal cancer is a rare condition. The inguinal lymph nodes are the most common site of metastasis in this neoplasm. The inguinal lymph node status is an important prognostic indicator and the presence of metastases is an independent prognostic factor for local failure and overall mortality. Depending on the primary tumor size and histological differentiation, metastasis to superficial inguinal lymph nodes occurs in 15-25% of cases. Methods and Study Design To evaluate the inguinal lymph node status we performed a search for the sentinel node in a female patient affected by s

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Cormio, G., A. Lissoni, A. Maneo, M. Marzola, A. Gabriele, and C. Mangioni. "Lymph node involvement in primary carcinoma of the fallopian tube." International Journal of Gynecologic Cancer 6, no. 5 (1996): 405–9. http://dx.doi.org/10.1136/ijgc-00009577-199609000-00010.

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Although the bad prognosis of primary fallopian tube carcinoma has been mostly ascribed to early lymphogenous dissemination, precise information regarding the characteristics of retroperitoneal spread are still missing. Our study was designed to evaluate the incidence and clinical significance of lymph node metastases in 33 patients with primary carcinoma of the fallopian tube. During primary surgery nine patients (27%) were submitted to systematic pelvic and para-aortic lymphadenectomy, whereas 24 received lymph node sampling. The clinicopathologic characteristics of the patients(intraperiton

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Ren, Ningning, Chong Geng, Kailin Liu, Jintao Ren, Xuan Zhang, and Xingsong Tian. "Postoperative recurrence of diffuse sclerosing thyroid cancer in an adolescent patient: A case report." Medicine 103, no. 7 (2024): e37246. http://dx.doi.org/10.1097/md.0000000000037246.

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Background: Papillary thyroid cancer is an inert malignant tumor with a good response to surgical treatment, low recurrence and metastasis rate, and good prognosis. Diffuse sclerosing thyroid cancer is an invasive subtype that is more common in young people, with a higher rate of lymph node metastasis and recurrence, and a relatively poor prognosis. Patient concerns: A 13-year-old girl underwent radical surgery for diffuse sclerosing thyroid cancer. Eight years later, due to a large number of lymph node metastases, she underwent another radical surgery on her neck lymph nodes. Methods: The pat

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12

Tsyplakov, D. E. "Regional lymph nodes and hematogenous metastasis of cancer." Kazan medical journal 102, no. 5 (2021): 757–64. http://dx.doi.org/10.17816/kmj2021-757.

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Aim. Morphological study of the microvasculature of regional lymph nodes in relation to the cancer of the lymph nodes as possible additional or alternative metastasis pathways. Methods. The lymph nodes of 150 cancer patients (1263 nodes in total), regional to cancer of various localization, were studied. Histological sections staining with hematoxylin and eosin by Van-Giesons method, pyronine by Brachets method, toluidine blue and picro-Mallory were prepared. An immunohistochemical study was performed using monoclonal antibodies to pan-cytokeratins, CD31, type IV collagen, CD3, CD20, and

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Aksarin, A. A., M. D. Ter-Ovanesov, A. A. Mordovsky, S. M. Kopeyka, and P. P. Troyan. "LOBE-SPECIFIC METASTASIS IN NON-SMALL CELL LUNG CANCER." Siberian journal of oncology 20, no. 5 (2021): 31–40. http://dx.doi.org/10.21294/1814-4861-2021-20-5-31-40.

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Aim: to identify the pathways of lymph node metastases in non-small cell lung cancer (NSCLC).Material and Methods. The frequency of mediastinal lymph node metastases and treatment outcomes were analyzed in 327 patients with stage I–III non-small cell lung carcinoma (NSCLC), who underwent lung resection with systematic lymph node dissection (SLND) between 2007 and 2011.Results. In cases with tumor location in any lobe of the right lung, metastasis occurred in the superior and inferior mediastinal lymph nodes. In left-side tumors, the main pathways of lymphatic spread of tumors were superior and

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Parshin, V. S., A. A. Veselova, V. S. Medvedev, S. A. Ivanov, and A. D. Kaprin. "LEVELS I–VII FOLLOWING THYROIDECTOMY FOR PAPILLARY THYROID CANCER." Siberian journal of oncology 19, no. 5 (2020): 76–81. http://dx.doi.org/10.21294/1814-4861-2020-19-5-76-81.

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Introduction. Cervical lymph node metastases can occur not only in patients when they are first diagnosed with papillary thyroid cancer but also in patients who have undergone thyroidectomy. Objective. The aim of this study was to assess the potential utility of neck ultrasound in diagnosing cervical lymph node metastases (levels I–VII) in patients who underwent surgical treatment for papillary thyroid cancer.Material and Methods. B-mode sonography of all nodal levels in the neck was performed using a linear array transducer in the frequency range of 7.5–13 MHz, power mapping and panoramic sca

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Mudunov, A. M., I. M. Gelfand, M. A. Kropotov та ін. "Improved diagnostics of “concealed” metastases in patients with сТ1–2N0М0 oral squamous cell carcinoma". Head and Neck Tumors (HNT) 12, № 1 (2022): 12–25. http://dx.doi.org/10.17650/2222-1468-2022-12-1-12-25.

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Introduction. Oral squamous cell carcinoma is associated with a high risk of regional metastasis even in early stages (T1–2N0M0). Morphological examination reveals concealed metastases in 20 % of removed clinically unaffected lymph nodes.Objective – to evaluate the effectiveness of flow cytometry for detection of concealed metastases in sentinel lymph nodes as an indication for cervical lymph node dissection in patients with stage сT1–2N0M0 oral squamous cell carcinoma.Materials and methods. This study included 27 patients, including 13 patients (48.1 %) with stage T1N0M0 cancer and 14 patient

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Li, Chuang, Zhao-zhong Meng, Jian-wu Qin, and Xin-guang Qiu. "Analysis of Risk Factors of Level V Lymphatic Metastasis for Papillary Thyroid Carcinoma with pN1b." Journal of Oncology 2021 (August 18, 2021): 1–5. http://dx.doi.org/10.1155/2021/5562065.

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Objective. To explore the risk factors of level V lymphatic metastasis in papillary thyroid carcinoma (PTC) patients with pN1b. Methods. Patients were selected if they presented with a suspicious level III or IV lymph node metastasis and underwent surgery by hemi or total thyroidectomy with a lymph node dissection (levels III, IV, VI, and VII). For these patients, if frozen section showed a positive level III or IV node, then levels II and V nodes were resected. Univariate analysis was performed using the chi-square test for some factors, including age, sex, tumor location, multifocal lesions,

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Terada, Tetsuya, and Ryo Kawata. "Role of Intra-Parotid Lymph Node Metastasis in Primary Parotid Carcinoma." Life 12, no. 12 (2022): 2053. http://dx.doi.org/10.3390/life12122053.

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The parotid gland contains intra-glandular lymph nodes, the distribution of which is crucial for understanding the pathogenesis of intra-parotid lymph node metastases of parotid carcinoma and other head and neck carcinomas. Positive intra-parotid lymph node metastasis predicts the risk of positive cervical nodal metastasis. It is important to establish whether prophylactic neck dissection, including intra-parotid lymph nodes, contributes to treatment outcomes. The presence or absence of intra-parotid lymph nodes or metastasis-positive lymph nodes warrants further study. A preoperative diagnosi

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Higashi, Yutaro, Kodai Nakamura, Ryota Takaoka, et al. "Identification of Neck Lymph Node Metastasis-Specific microRNA—Implication for Use in Monitoring or Prediction of Neck Lymph Node Metastasis." Cancers 15, no. 15 (2023): 3769. http://dx.doi.org/10.3390/cancers15153769.

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MicroRNAs (miRNAs) have attracted attention as non-invasive cancer biomarkers in various cancers; however, they have not been adequately investigated in oral squamous cell carcinoma (OSCC). This study investigated the diagnostic performance of serum-derived miRNAs at initial diagnosis for primary neck lymph node metastasis and the predictive performance for late neck lymph node metastasis based on long-term (up to approximately 8 years) follow-up of patients with OSCC. The expression of miRNAs in 40 patients with OSCC was quantified using real-time PCR (qPCR), and a comprehensive statistical a

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Parshin, V. S., A. A. Veselova, V. S. Medvedev, S. A. Ivanov, and A. D. Kaprin. "Ultrasound diagnosis of cervical levels II–IV lymph node metastasis in patients with first diagnosed papillary thyroid cancer." Head and Neck Tumors (HNT) 9, no. 4 (2020): 17–23. http://dx.doi.org/10.17650/2222-1468-2019-9-4-17-23.

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The study objective is to explore the potentialities of ultrasound in the detection of metastasis from papillary thyroid cancer (PTC) to cervical lymph nodes in levels II–IV.Materials and methods. In 97 patients with first diagnosed PTC, surgical removal of the cervical lymph node-bearing fat at levels II–IV was performed. All patients underwent preoperative neck ultrasound. The results were verified by histology.Results. Cervical levels II–IV lymph node metastases were revealed in 82 (84,5 %) cases by sonography and in 86 (88,6 %) cases by histology. Ultrasound showed a sensitivity of 93 %, s

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Bharapuria, Kanishka, and Kamlakar Reddy. "Cystic Lymph Node Metastases in Papillary Thyroidcarcinoma." International Journal of Science and Research (IJSR) 11, no. 12 (2022): 1102–4. http://dx.doi.org/10.21275/sr221223093627.

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Wade, Zane K., John E. Shippey, Gregory A. Hamon, Robert L. Smoak, Pedram Argani, and William C. Allsbrook. "Collision Metastasis of Prostatic and Colonic Adenocarcinoma: Report of 2 Cases." Archives of Pathology & Laboratory Medicine 128, no. 3 (2004): 318–20. http://dx.doi.org/10.5858/2004-128-318-cmopac.

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Abstract Collision metastases of carcinomas in lymph nodes are rare. Carcinoma metastasizing to lymph nodes containing malignant lymphoma has also been reported. The literature contains 3 cases of collision metastasis of prostatic and urothelial carcinoma. To our knowledge, we report the first 2 cases of collision metastasis of prostatic and colonic adenocarcinoma, one involving a mesenteric lymph node and the other involving a perirectal lymph node, both from resections for colonic adenocarcinoma in patients with known metastatic prostatic carcinoma.

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Hoving, Hilde, Karen Campos, and Igle De Jong. "EpCAM expression in lymph node and bone metastases of prostate carcinoma: A pilot study." Journal of Clinical Oncology 32, no. 4_suppl (2014): 165. http://dx.doi.org/10.1200/jco.2014.32.4_suppl.165.

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165 Background: Correct staging of prostate carcinoma has huge treatment implications since metastasized prostate carcinoma cannot be treated curatively. Nowadays, skeletal scintigraphy is the mainstay for the assessment for bone metastases despite its poor sensitivity. Lymph node metastases can be diagnosed accurately with Computed Tomography. However, the gold standard is a pelvic lymph node dissection. A non-invasive diagnostic modality, that can assess both lymph node and bone metastases simultaneously, is preferred. In this retrospective pilot study expression of epithelial cell adhesion

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Ershov, Vladimir A., Ada V. Anisimova, Sergei M. Vashkurov, et al. "FEATURES OF DEFEATS OF SENTINEL LYMPH NODES AT PRIMARY MELANOMA OF SKIN." Scientific Notes of the Pavlov University 26, no. 1 (2019): 54–60. http://dx.doi.org/10.24884/1607-4181-2019-26-1-54-60.

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Introduction. Each tenth tumor of skin is melanoma. Presence of tumor cells in sentinel lymph node influenced the medical tactics.The objective of the research was to study the metastasis of skin melanoma into the clinically negative regional lymph nodes.Material and methods. Histological, immunohistochemical, cytological and immunocytochemical methods were used to study biopsies of regional lymph nodes in 60 patients with skin melanoma.Results. 5 % of patients were diagnosed with melanoma in situ, 15 % – Т1, 28.3 % – Т2, 23.3 % – Т3, 28.3 % – Т4. At outflow of the lymph through 1 collector, t

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Machens, Andreas, Kerstin Lorenz, Frank Weber, and Henning Dralle. "Metastatic Risk Profile of Microscopic Lymphatic and Venous Invasion in Medullary Thyroid Cancer." Hormone and Metabolic Research 53, no. 09 (2021): 588–93. http://dx.doi.org/10.1055/a-1559-3424.

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AbstractThe metastatic risk profile of microscopic lymphatic and venous invasion in medullary thyroid cancer is ill-defined. This evidence gap calls for evaluation of the suitability of microscopic lymphatic and venous invasion at thyroidectomy for prediction of lymph node and distant metastases in medullary thyroid cancer. In this study of 484 patients with medullary thyroid cancer who had≥5 lymph nodes removed at initial thyroidectomy, microscopic lymphatic and venous invasion were significantly associated with greater primary tumor size (27.6 vs. 14.5 mm, and 30.8 vs. 16.2 mm) and more freq

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Dong, Xu, Yu Chunrong, Hou Hongjun, and Zhang Xuexi. "Differentiating the lymph node metastasis of breast cancer through dynamic contrast-enhanced magnetic resonance imaging." BJR|Open 1, no. 1 (2019): 20180023. http://dx.doi.org/10.1259/bjro.20180023.

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Objective: Lymph node metastasis is an important trait of breast cancer, and tumors with different lymph node statuses require various clinical treatments. This study was designed to evaluate the lymph node metastasis of breast cancer through pharmacokinetic and histogram analysis via dynamic contrast-enhanced (DCE) MRI. Methods and materials: A retrospective analysis was conducted to quantitatively evaluate the lymph node statuses of patients with breast cancer. A total of 75 patients, i.e. 34 patients with lymph node metastasis and 41 patients without lymph node metastasis, were involved in

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Lin, Y. S., C. C. Tzeng, K. F. Huang, C. Y. Kang, C. C. Chia, and J. F. Hsieh. "Sentinel node detection with radiocolloid lymphatic mapping in early invasive cervical cancer." International Journal of Gynecologic Cancer 15, no. 2 (2005): 273–77. http://dx.doi.org/10.1136/ijgc-00009577-200503000-00014.

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We assessed the feasibility of sentinel lymph node detection using technicium-99 radiocolloid lymphatic mapping for predicting lymph node metastases in early invasive cervical cancer. Thirty patients with cervical cancer (stages IA2–IIA) underwent preoperative lymphoscintigraphy using technicium-99 intracervical injection and intraoperative lymphatic mapping with a handheld gamma probe. After dissection of the sentinel nodes, the standard procedure of pelvic lymph node dissection and radical hysterectomy was performed as usual. The sentinel node detection rate was 100% (30/30). There were seve

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Suzuki, Hiroyoshi, Seishi Jinnouchi, Yasushi Kaji, et al. "Diagnostic performance of 18F-fluciclovine PET/CT for regional lymph node metastases in patients with primary prostate cancer: a multicenter phase II clinical trial." Japanese Journal of Clinical Oncology 49, no. 9 (2019): 803–11. http://dx.doi.org/10.1093/jjco/hyz072.

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18F-fluciclovine PET/CT was evaluated in the diagnosis of lymph node metastases. Of 40 lymph nodes, metastasis was confirmed by pathology in seven, and four were positive for metastasis by 18F-fluciclovine.

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Sorgho, Alice Wendpanga, C. El Alouani, M. Khouchani, et al. "Cervix uterine Cancer with Axillary and Neck Lymph Node Metastasis: An Unusual Finding." Scholars Journal of Applied Medical Sciences 11, no. 10 (2023): 1834–39. http://dx.doi.org/10.36347/sjams.2023.v11i10.012.

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Background: Cervix uterii cancer is the fourth most common female malignancy. It commonly spreads by direct extension or lymphatic dissemination within the pelvis into the regional lymph nodes. Distant lymph node metastasis remains exeptionnal. To our knowledge, synchronous cervical and axillary lymph node metastasis from cervix cancer have never been reported. Here we report a case of cervical and axillary lymph node metastasis from cervix uterii cancer. Case presentation: A 51-year-old woman diagnosed with cervix uterii cancer and treated with cocomitant chemoradiotherapy, presented 8 months

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Colby, Thomas V. "Lymph Node Metastases." American Journal of Surgical Pathology 26, no. 8 (2002): 1089. http://dx.doi.org/10.1097/00000478-200208000-00019.

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Goldstein, Neal. "Lymph Node Metastases." American Journal of Surgical Pathology 26, no. 8 (2002): 1089. http://dx.doi.org/10.1097/00000478-200208000-00020.

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Santin, Alessandro D. "Lymph node metastases." Cancer 88, no. 1 (2000): 175–79. http://dx.doi.org/10.1002/(sici)1097-0142(20000101)88:1<175::aid-cncr24>3.0.co;2-f.

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Sioletic, Stefano, Libero Lauriola, Enzo Gallo, et al. "Diagnostic Features and Subtyping of Thymoma Lymph Node Metastases." BioMed Research International 2014 (2014): 1–5. http://dx.doi.org/10.1155/2014/546149.

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Aim.The purpose of the present study was to characterize the morphological features of thymoma metastases in lymph nodes and to evaluate the possibility of their subtyping according to the 2004 WHO classification of thymus tumors.Materials and Methods.We reviewed 210 thymoma cases in our series of thymic epithelial tumors (TET), including their recurrences and lymphogenous metastases. Three cases of lymph node metastases, one case occurring synchronously with the primary tumor and one synchronously with the first relapse (both in intrathoracic location) and one case of metastasis observed in a

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Abramova, O. E., D. V. Kudryavtsev, A. A. Kurilchik, and S. A. Ivanov. "Regional lymphadenectomy in the treatment of patients with melanoma skin with metastases in the sentinel lymph nodes." Bone and soft tissue sarcomas, tumors of the skin 15, no. 1 (2023): 28–37. http://dx.doi.org/10.17650/2219-4614-2023-15-1-28-37.

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Regional recurrences are one of the most common first manifestations of progression of clinically localized cutaneous melanoma. They are caused by subclinical metastases in the lymph nodes. Biopsy of the sentinel lymph nodes is the most effective method of detection of hidden regional metastases. It allows to appropriately increase the volume of surgical treatment prior to dissection of the affected lymph collector and perform adjuvant therapy with the most effective drugs. This, in its turn, allows for significant improvement of regional and systemic control of the disease and long-term treat

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Morohashi, Hajime, Yoshiyuki Sakamoto, Takuya Miura, et al. "Effective dissection for rectal cancer with lateral lymph node metastasis based on prognostic factors and recurrence type." International Journal of Colorectal Disease 36, no. 6 (2021): 1251–61. http://dx.doi.org/10.1007/s00384-021-03870-5.

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Abstract Purpose There are no reports showing the significance and effective range of dissection for patients with lateral lymph node metastasis (LLNM). This study aimed to investigate the indications for lateral lymph node dissection (LLND) in patients with LLNM based on prognostic factors and recurrence types. Methods We reviewed 379 patients with advanced rectal cancer who were treated with total mesorectal excision plus LLND. We analyzed background factors and survival times of patients who had LLNM to determine prognostic factors and recurrence types. Results Pathological LLNM occurred in

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Parshin, V. S., A. D. Kaprin, S. A. Ivanov, A. A. Veselova, P. I. Garbuzov, and V. S. Medvedev. "Ultrasound diagnosis of cervical lymph node metastases in patients with first diagnosed papillary thyroid cancer and in patients previously treated surgically and admitted for radioactive iodine therapy." Research and Practical Medicine Journal 7, no. 2 (2020): 47–55. http://dx.doi.org/10.17709/2409-2231-2020-7-2-4.

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Purpose of the study. To evaluate the potentialities of ultrasound method in diagnosing cervical lymph node metastasis in patients with first diagnosed papillary thyroid cancer (group 1) and in patients previously treated surgically at different clinics of the Russian Federation and subsequently admitted to the A.F.Tsyb Medical Radiological Research Center — Branch of the National Medical Research Radiological Center to receive radioactive iodine therapy (group 2).Patients and methods. Patients with PTC were divided into two groups. Group 1 included 649 patients with first diagnosed PTC. All t

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Suh, Byoung Jo. "A Case of Advanced Gastric Cancer with Para-Aortic Lymph Node Metastasis Treated with Preoperative FOLFOX Chemotherapy Followed by Radical Subtotal Gastrectomy and D2 Lymph Node Dissection." Case Reports in Oncology 10, no. 1 (2017): 182–91. http://dx.doi.org/10.1159/000457791.

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We report the case of a 73-year-old female who was diagnosed with advanced gastric cancer. Esophagogastroduodenoscopy was used to diagnose Borrmann type 3 advanced gastric cancer located at the gastric antrum. A biopsy revealed poorly differentiated adenocarcinoma. Abdominopelvic computed tomography (CT) and 18F-fluorodeoxyglucose positron emission tomography-CT (FDG-PET-CT) scans demonstrated multiple lymph node metastases, including the para-aortic lymph nodes. Systemic chemotherapy with 5-fluoruracil (5-FU), oxaliplatin, and leucovorin (FOLFOX) was initiated. An abdominopelvic CT scan taken

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Yin, Yue-ju, Hui-qin Li, Xiu-gui Sheng, Xing-lan Li, and Xiang Wang. "Distribution Pattern of Circumflex Iliac Node Distal to the External Iliac Node Metastasis in Stage IA to IIA Cervical Carcinoma." International Journal of Gynecologic Cancer 24, no. 5 (2014): 935–40. http://dx.doi.org/10.1097/igc.0000000000000138.

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ObjectivesThis study aimed to investigate the metastatic rate of circumflex iliac node distal to the external iliac node (CINDEIN) and its associations with clinicopathological factors in patients with stage IA to IIA cervical cancer to determine whether dissection of CINDEIN had a role in surgery of these patients.MethodsSix hundred thirty-three patients with the International Federation of Gynecology and Obstetrics stage IA to IIA cervical cancer who underwent radical hysterectomy and pelvic lymphadenectomy were retrospectively reviewed. The metastatic rate and distribution of the pelvic lym

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Shiga, Kiyoto, Katsunori Katagiri, and Daisuke Saito. "PS01.126: LYMPH NODE METASTASES AND NECK DISSECTION FOR THE PATIENTS WITH CERVICAL ESOPHAGEAL CANCER." Diseases of the Esophagus 31, Supplement_1 (2018): 85. http://dx.doi.org/10.1093/dote/doy089.ps01.126.

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Abstract Background Cervical esophageal cancer (CEC) is a relatively rare disease but the outcomes of the patients with CEC are often poor. Lymph node metastases in the neck sometimes play a crucial role to treat the patients. The aim of this study is to evaluate the lymph node metastases and neck dissection for the patients with CEC. Methods Retrospective review of the records of the patients. Five patients with CEC who underwent total pahryngo-laryngectomy plus cervical esophagectomy were enrolled in this study. We analyzed the places of lymph node metastases of the patients and the relation

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Hirakawa, Satoshi, Lawrence F. Brown, Shohta Kodama, Karri Paavonen, Kari Alitalo, and Michael Detmar. "VEGF-C–induced lymphangiogenesis in sentinel lymph nodes promotes tumor metastasis to distant sites." Blood 109, no. 3 (2006): 1010–17. http://dx.doi.org/10.1182/blood-2006-05-021758.

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Abstract The mechanisms by which tumors metastasize to sentinel and distant lymph nodes, and beyond, are poorly understood. We developed transgenic mice that overexpress vascular endothelial growth factor-C (VEGF-C) and green fluorescent protein specifically in the skin and studied the effects of chemically-induced skin carcinogenesis in this model. We found that in contrast to VEGF-A, VEGF-C does not increase the growth of primary tumors, but instead induces expansion of lymphatic networks within sentinel lymph nodes, even before the onset of metastasis. Once the metastatic cells arrived at t

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Tominaga, Shusei. "Prediction of the non-sentinel node metastasis in patients without clinically axillary lymph node metastasis, with implication of breast cancer subtypes." Journal of Clinical Oncology 30, no. 15_suppl (2012): e13060-e13060. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.e13060.

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e13060 Background: The accuracy of the nomogram about non-sentinel lymph node metastasis (NSLNM ) in breast cancer patients is still controversial to avoid axillary dissection particularly sentinel lymph node biopsy was positive. The aim of this study was to evaluate the necessity of adding breast cancer subtypes to the NSLNM nomgram variables. Methods: Between 2009 and 2011, consecutive breast cancer patients without clinically axillary lymph node metastasis (n=140) who received sentinel lymph node biopsy at Higashiosaka General Hospital were studied retrospectively. Twenty-two patients were

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Parshin, V. S., S. A. Ivanov, A. D. Kaprin, et al. "Initial Ultrasound Criteria for the Diagnosis of Cervical Lymph Node Metastases from Papillary Thyroid Cancer." Journal of oncology: diagnostic radiology and radiotherapy 5, no. 3 (2022): 43–53. http://dx.doi.org/10.37174/2587-7593-2022-5-3-43-53.

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Introduction: Cervical lymph node metastases from papillary thyroid cancer were classified into three categories according to ultrasound: 1) Metastases were not visible on ultrasound; 2) Metastases met initial criteria for the diagnosis; 3) Metastases met typical criteria for the diagnosis. Purpose: To develop initial ultrasound criteria for the diagnosis of cervical lymph node metastases from papillary thyroid cancer. Material and methods: We studied three groups of cervical lymph nodes in patients with papillary thyroid cancer. The first group consisted of 4307 lymph nodes that were not visi

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Nguyen Van, Dang, Thao Bich Nguyen, Nhung Thu Nguyen Thi, and Quang Le Van. "Report on Unusual Sites of Lymph Node Metastases in Nasopharyngeal Carcinoma." Case Reports in Oncology 14, no. 3 (2021): 1821–26. http://dx.doi.org/10.1159/000520977.

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Nasopharyngeal carcinoma (NPC) is amongst the most common malignancies of head and neck cancers. Most patients are admitted to the hospital with advanced disease. NPC has a tendency toward early metastatic spread to cervical lymph nodes, and levels II and III are most commonly involved. A few reports have indicated specific metastatic sites of nasopharyngeal cancer, including lymph node metastasis and distant metastasis. Evidence of histopathology and immunohistochemistry is required to prove NPC origin. In many cases, surgery can be performed to obtain accurate evidence of the pathology. Howe

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Prashanth V, Nandhana, Saravanan P, and Vivekananda Nathan. "Evaluation of lymph node status in cancer patients during pandemic period." Journal of Clinical and Investigative Surgery 7, no. 2 (2022): 169–73. http://dx.doi.org/10.25083/2559.5555/7.2.9.

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Background. This is a clinicopathological study comparing lymph node involvement in breast carcinomas before and during the COVID-19 period. During the pandemic, access to healthcare was limited, which led to a delay in the diagnosis and treatment of malignant tumors, which often presented in advanced stages, with lymph node metastases. Methods. A retrospective study was performed on 40 patients with carcinomas treated by surgical excision of the tumor combined with lymph node resection. Histopathological examination of lymph nodes was performed to detect malignant metastases, and the mean lym

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Lessard, L., P. Bellon-Gagnon, M. Alam-Fahmy, P. Karakiewicz, A. Mes-Masson, and F. Saad. "Nuclear localization of NF-kappaB p65 in primary prostate tumors is predictive of pelvic lymph node metastases." Journal of Clinical Oncology 24, no. 18_suppl (2006): 10077. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.10077.

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10077 Background: Pelvic lymph node metastases are associated with a greater risk of prostate cancer recurrence and peripheral metastasis. Unfortunately, markers predictive of lymph node metastasis and/or recurrence after radical prostatectomy are limited and new molecular markers are needed to identify patients at higher risk of progression. NF-kB (p65) is a candidate molecular marker already associated with poor clinical outcomes such as biochemical recurrence and bone metastasis. We have also reported elevated nuclear p65 expression in prostate cancer lymph node metastasis. Pertinent to thi

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Hulahan, Taylor S., Yeonhee Park, Laura Spruill, Hari Nakshatri, Marvella Ford, and Peggi M. Angel. "429 Spatial Investigation of the Extracellular Matrix Metastatic Niche in Invasive Breast Cancer by Mass Spectrometry Imaging." Journal of Clinical and Translational Science 8, s1 (2024): 128. http://dx.doi.org/10.1017/cts.2024.371.

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OBJECTIVES/GOALS: Metastasis to regional areas decreases invasive breast cancer (IBC) survival rate by 13%. Despite the clinical importance of lymph node involvement, the role of extracellular matrix (ECM) remodeling in metastases is unknown. We hypothesize that the spatial dysregulation of the collagen proteome facilitates pro-tumorigenic immune infiltration. METHODS/STUDY POPULATION: Lymph node metastases were compared to patient-matched primary tumor and normal lymph nodes using tissue microarrays (TMA) from 31 generational South Carolina women with IBC (black women, BW n=10, white women, W

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NW, Armerinayanti, Bakta IM, Alit Artha IG, Wahyuniari IAI, and Samuel Widodo. "Overexpression of MicroRNA 21 in Cervical Carcinoma with Lymph Node Metastasis." Biomedical and Pharmacology Journal 16, no. 1 (2023): 479–85. http://dx.doi.org/10.13005/bpj/2628.

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Cervical carcinoma being the second common cancer in women in Indonesia, as well as in Bali, and mostly patients are diagnosed at an advanced stage with having metastases. The lymphatic pathway (lymph nodes) is the most frequent route for cervical cancer metastases. MicroRNA is a novel invention for predicting the biological behavior of cervical carcinoma and has the potential to act as the foundation for targeted therapy for cervical cancer. Several microRNA profiles, including microRNA 21, microRNA 126, and microRNA 143, were discovered to regulate the biological activity of cervical cancer.

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Wei, Xi, Meng Wang, Xiaoqing Wang, et al. "Prediction of cervical lymph node metastases in papillary thyroid microcarcinoma by sonographic features of the primary site." Cancer Biology & Medicine 16, no. 3 (2019): 587–94. http://dx.doi.org/10.20892/j.issn.2095-3941.2018.0310.

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Objective: To study the sonographic features of the primary site of papillary thyroid microcarcinoma (PTMC) for the prediction of cervical lymph node metastasis during preoperative diagnosis. Methods: A total of 710 PTMC patients between 2013 and 2016 with a diagnosis of cervical lymph node metastases were reviewed. We analyzed the sonographic features of the PTMC primary site to predict ipsilateral or central lymph node metastases in univariate and multivariate models. The ratio of abutment/perimeter of the PTMC primary site was utilized to evaluate cervical lymph node status. Results: Regard

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Vrancken Peeters, Marie-Jeanne TFD, Marieke Evelien Straver, Mila Donker, et al. "Novel surgical technique to selectively remove metastatic axillary lymph nodes in breast cancer patients after neoadjuvant chemotherapy: The MARI procedure—Marking of the axilla with radioactive iodine seeds." Journal of Clinical Oncology 30, no. 27_suppl (2012): 196. http://dx.doi.org/10.1200/jco.2012.30.27_suppl.196.

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196 Background: An important benefit of neoadjuvant chemotherapy (NAC) is the increase in breast-conserving surgery. At present the response of axillary lymph node metastases to chemotherapy cannot be accurately assessed. Therefore axilla-conserving therapy is not yet a benefit. We aimed to assess a new surgical method to evaluate the axillary response: the MARI procedure, which stands for Marking of the Axillary lymph node with Radioactive Iodine seeds. Methods: Prior to NAC, proven tumor-positive axillary lymph nodes were marked with a Iodine-125 seed. After NAC, the marked lymph node was se

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Ozawa, Heita, Hiroki Nakanishi, Junichi Sakamoto, Yoshiyuki Suzuki, and Shin Fujita. "Prognostic impact of the number of lateral pelvic lymph node metastases on rectal cancer." Japanese Journal of Clinical Oncology 50, no. 11 (2020): 1254–60. http://dx.doi.org/10.1093/jjco/hyaa122.

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Abstract Background This study aimed to clarify the number of lateral pelvic lymph node metastases of colorectal cancer for which prognosis could be improved by dissection. Methods We analysed the data of 30 patients with lateral pelvic lymph node metastases of rectal cancer that underwent a total mesorectal excision with lateral pelvic lymph node dissection at our institute from 1986 to 2016. We performed survival analysis on the number of lateral pelvic lymph node metastases in each of these patients and identified an optimal cut-off point of the number of lateral pelvic lymph node metastase

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Zhang, Xiao, Saihua Chen, Guangxiao Li, et al. "Investigating the influence of primary uterine tumor site on pelvic and para-aortic lymph node metastatic pattern and evaluating the risk factors for lymph node metastases in endometrial carcinoma: A retrospective study." Medicine 102, no. 47 (2023): e36100. http://dx.doi.org/10.1097/md.0000000000036100.

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To assess the metastatic pattern in pelvic and para-aortic lymph nodes in relation with the primary uterine tumor site and to evaluate risk factors for lymph node metastases. 212 patients with endometrial cancer who underwent surgical treatment from December 2014 to December 2019 were selected. The clinical and pathological data were retrospectively analyzed. The factors and uterine primary tumor site related to lymph node metastasis were analyzed by univariate and multivariate analysis. Among the 212 patients with endometrial cancer, 17 cases had lymph node metastasis, and thus the metastasis

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