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Dissertations / Theses on the topic 'Lymphangion'

Author: Grafiati

Published: 4 June 2021

Last updated: 7 February 2022

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1

Madabushi, Venugopal Arun. "A computational approach to study the effect of multiple lymphangion coordination on lymph flow." Thesis, Texas A&M University, 2004. http://hdl.handle.net/1969.1/2670.

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The lymphatic system acts to return fluid from the interstitial space back into the blood circulation. In normal conditions, lymphangions, the segment of lymphatic vessel in between valves, cyclically contract and can pump lymph from low pressure tissues to the higher-pressure veins of the neck. With edema, however, this pressure gradient can reverse, and the role of contraction is less clear. Like ventricles, lymphangions are sensitive to both preload and afterload. Unlike ventricles, lymphangions are arranged in series, so that the outlet pressure of one lymphangion becomes the inlet pressure of another. Anything that alters the relative timing and frequency of adjacent lymphangions alters both preload and afterload of each lymphangion and thus mean lymph flow. To explore the effect of timing and frequency of contraction on lymph flow, we developed a computational model of a lymphatic vessel with lymphangions described by the classic description of time-varying elastance. When pumping up a pressure gradient, as in normal conditions, or when pumping down a pressure gradient, as in some cases of edema, we found that flow was optimized when the lymphangions in the vessel were pumping with a very short time delay between their cycles, and the flow was reduced when the time delay between the contractions was reduced to zero. However, a difference in frequency between adjacent lymphangions alters instantaneous flow but does not affect mean flow. These results suggest an important role for the timing of the contraction in optimizing lymph flow. However, a difference in frequencies between adjacent lymphangions has little effect on altering lymph flow, suggesting that tight control of lymphangion coordination may not be critical for lymphatic function.

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2

Rouard, Christophe. "Lymphangiome kystique de la rate : à propos d'un cas et revue de la littérature." Montpellier 1, 1995. http://www.theses.fr/1995MON11171.

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3

Rajagopalan, Shruti. "Device for automating in vitro characterization of lymphatic vessel function." Texas A&M University, 2004. http://hdl.handle.net/1969.1/1323.

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The lymphatic system consists of a network of vessels which work to return the interstitial fluid back to the blood circulation. Individual units called lymphangions, segments of lymphatic vessels between two valves, pump cyclically to propel lymph. Lymphangions are similar to the heart in that they are sensitive to both preload and afterload. To describe the heart independent of preload and afterload, investigators developed the concept of time-varying elastance. We evaluated the applicability of this concept to lymphangions by analyzing preliminary data obtained from the bovine mesenteric vessels. We found that there were some limitations to the applicability of this concept to lymphangions, as there was a high degree of variability with respect to contraction strength and frequency of individual time-varying elastance curves. To better characterize lymphangion mechanics, we built a device which would enable real-time isobaric, isometric and isotonic experiments in vitro. We performed all three experiments on lymphatic vessel segments and obtained input and output pressures, output flow, instantaneous radii and wall tension. The characterization of the lymphangion using these parameters can be the first step to simulate the behavior of a lymphatic vesssel and later the behavior of an entire lymphatic system.

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4

SENNEVILLE, ISABELLE. "Le lymphangiome vulvaire : a propos d'une observation." Lille 2, 1988. http://www.theses.fr/1988LIL2M162.

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5

TAHON, OLIVIER. "Lymphangiome du foie : a propos de deux cas et revue de la litterature." Amiens, 1988. http://www.theses.fr/1988AMIEM020.

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6

Saldar, Khan Isabelle. "Lymphangiome kystique du petit epiploon de l'adulte." Bordeaux 2, 1990. http://www.theses.fr/1990BOR25001.

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7

BUDIN, HERVE. "Etude anatomo-clinique des lymphangiomes kystiques du mediastin : a propos de deux observations personnelles ; revue de la litterature." Lyon 1, 1990. http://www.theses.fr/1990LYO1M048.

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8

Weiland, Nadine. "Lymphangiome kystique du pancreas : a propos d'un cas ; revue de la litterature." Nancy 1, 1992. http://www.theses.fr/1992NAN11180.

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9

LETURQUE, JACQUES. "Le lymphangiome kystique peritoneal de l'adulte : a propos d'un cas." Amiens, 1992. http://www.theses.fr/1992AMIEM008.

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10

Hajimirsadeghi, Elham. "Le lymphangiome kystique du médiastin à extension cervicale : à propos d'un cas." Montpellier 1, 1995. http://www.theses.fr/1995MON11162.

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11

Decaudin, Audrey Héloury Yves. "Le lymphangiome kystique diagnostic anténatal et prise en charge /." [S.l.] : [s.n.], 2008. http://castore.univ-nantes.fr/castore/GetOAIRef?idDoc=51196.

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12

Vincent, Gilles. "Les lymphangiomes kystiques abdominaux chez l'enfant : a propos de 5 observations." Clermont-Ferrand 1, 1991. http://www.theses.fr/1991CLF13033.

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13

BRIOIS, CATHERINE. "Hemolymphangiome kystique de la surrenale : a propos de trois observations." Aix-Marseille 2, 1988. http://www.theses.fr/1988AIX20217.

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14

Descamps, Sophie. "Traitement percutane des lymphagiomes kystiques superficiels par injection d'ethibloc : a propos de 20 cas." Lille 2, 1993. http://www.theses.fr/1993LIL2M326.

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15

Lapouge, Farges Dominique. "Kystes mesenteriques de l'enfant : revue de la litterature a partir de deux observations personnelles." Limoges, 1988. http://www.theses.fr/1988LIMO0138.

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16

DUPONT, CATHERINE. "Le lymphangiome kystique du cou, diagnostic antenatal et prise en charge : a propos de six cas." Aix-Marseille 2, 1993. http://www.theses.fr/1993AIX20010.

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17

Koester, Sven. "Die chirurgische Versorgung cervikaler Lymphangiome im Kindesalter im Vergleich mit anderen Therapieverfahren." Diss., lmu, 2008. http://nbn-resolving.de/urn:nbn:de:bvb:19-83675.

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18

Köster, Sven. "Die chirurgische Versorgung cervikaler Lymphangiome im Kindesalter im Vergleich mit anderen Therapieverfahren." kostenfrei, 2008. http://edoc.ub.uni-muenchen.de/8367/.

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19

ERENA, ANNE-SOPHIE. "Lymphangite pulmonaire secondaire a un cancer prostatique : etude d'un cas revele par un trouble ventilatoire obstructif ; recul evolutif de 6 ans." Lyon 1, 1994. http://www.theses.fr/1994LYO1M166.

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20

PIQUET, LYDIE FRANCOISE MARIE. "Lymphamgiome kystique du cou : diagnostic echographique in utero : a propos de deux cas." Limoges, 1989. http://www.theses.fr/1989LIMO0157.

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21

Blesinger, Hannah Leonore [Verfasser]. "Untersuchung spezifischer Inhibitoren der PI3K-Signalkaskade zur Therapie des Lymphangioms / Hannah Leonore Blesinger." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2020. http://d-nb.info/1214887031/34.

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22

Nguyen, Van Nuoï Delphine. "Hémolymphangiome kystique intra-orbitaire chez l'enfant : diagnostic et prise en charge thérapeutique actuelle en 2009 : revue de la littérature." Antilles-Guyane, 2010. http://www.theses.fr/2010AGUY0316.

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L'hémolymphangiome kystique intra-orbitaire est une malformation vasculaire rare, bénigne mais potentiellement dangereuse pour la fonction visuelle. Ce travail propose une synthèse clinique et paraclinique, et une attitude thérapeutique. Les signes cliniques orientant vers cette lésion sont: une exophtalmie brutale ou progressive, unilatérale, sans souffle, non pulsatile, très peu variable à la manoeuvre de Valsalva. Il faut dépister les signes de gravité: neuropathie optique compressive, exposition cornéenne majeure, préjudice esthétique important (exorbitisme). L'IRM constitue l'examen de référence. En imagerie, la lésion est typique: une masse kystique polylobée pseudo encapsulée, avec des niveaux liquides intra-kystiques d'âges différents correspondant aux hémorragies récurrentes. Chez l'enfant. Cette lésion représente un challenge thérapeutique car il faut veiller à préserver un bon développement des structures anatomiques et fonctionnelles visuelles avant de penser au préjudice esthétique. Il faut insister sur la prévention des facteurs de risques d'aggravation ou de récidive: prévenir les infections des voies aériennes supérieures et les microtraumatismes. S'il n'existe pas de signes de complications, la priorité thérapeutique est la surveillance clinique. Des traitements non-invasifs conservateurs des structures nobles ont été développés: compression externe, corticothérapie. Pour les cas plus graves, la tendance actuelle est la décompression orbitaire chirurgicale avec résection lésionnelle la plus compléte possible. Des polyméres hémostatiques développés ces dernières années faciliteraient la chirurgie et diminuer le risque de récidive hémorragique
Orbital cystic Iymphangioma is a rare vascular malformation, benign but potentially dangerous for visual function. This work propose a clinical and paraclinical synthesis and treatement. The clinical presentation is: one side, no breathing, no beating, acute or progressive proptosis, with smalt expansion with Valsalva maneuver. Complications must have been detected: compressive optic neuropathy, major exorbitism, corneal exposure. MRI is the imaging reference. The imaging shows typical lesion: polycystic mass pseudo-encapsulated, with various aged intracystic hemorrhage. In children, the treatment of Iymphangioma is challenging because of try to preserve a normal anatomie development and a correct visual function. First, small traumatism and eared, nosed and throated infection have to be prevented. If Iymphangioma is not complicated, the observation is the treatment. Conservative and no-invasive treatment exist: external compression, corticosteroid. For severe form, surgical decompression with complete resection of the lesion is the reference of treatment. Hemostatic polymer are developed to help the surgery, reducing the risk of hemorrhage

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23

PADILLA, PIERRE-YVES. "Apport de l'ultrasonographie dans le diagnostic antenatal des malformations des parties molles." Nice, 1988. http://www.theses.fr/1988NICE6044.

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24

González, Luna Alejandro, Pizarro Jorge Luis Nuñez, and Echegaray Clodo Iván Rodríguez. "Presentación atípica del síndrome de Gorham-Stout. Caso clínico." Sociedad Argentina de Pediatría, 2015. http://hdl.handle.net/10757/555429.

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Gorham-Stout syndrome is an extremely rare pathology, of unknown etiology. It is characterized by proliferation of vascular channels that causes destruction and reabsorption of the bone matrix. We present a nine year-old male patient with an acute episode characterized by fever, chest pain, respiratory distress and dyspnea. The patient was submitted to computed tomography scan and a biopsy. The findings in the biopsy were multiple lytic lesions, osteolysis, and a mediastinal lymphangioma (lymphangiomatosis). The diagnosis was Gorham-Stout syndrome with atypical presentation.
jorgeluisnp@gmail.com
El síndrome de Gorham-Stout es una patología ósea extremadamente rara de etiología desconocida, caracterizada histopatológicamente por proliferación de los canales vasculares, que origina destrucción y resorción de la matriz ósea. Se presenta el caso de un paciente varón de nueve años de edad con un cuadro agudo caracterizado por fiebre, dolor torácico, dificultad respiratoria y disnea ante pequeños esfuerzos. Se realizaron estudios de imágenes y patología, en los que se encontraron lesiones liticas múltiples y presencia de un linfangioma mediastínico. Se diagnosticó síndrome de Gorham-Stout. Esta es una presentación atípica debido a la localización de la linfangiomatosis y al tamaño de la masa.

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25

SENETERRE, ERIC. "Initiation a l'analyse tomodensitometrique des maladies interstitielles pulmonaires." Montpellier 1, 1989. http://www.theses.fr/1989MON11335.

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26

Giese, Dina. "Lymphatische Malformationen im Kindesalter unter besonderer Berücksichtigung von Prognose und Spätergebnissen." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2005. http://dx.doi.org/10.18452/15360.

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In einer retrospektiven Studie über den Zeitraum von 1990-2000 wurden in der Klinik für Kinderchirurgie des Universitätsklinikums Charité, Berlin die Kinder untersucht, bei denen eine lymphatische Malformation aufgetreten war. Es ergaben sich insgesamt 18 Patienten. Parallel wurden aus der Klinik für Gynäkologie und Geburtshilfe, Abteilung für Pränatale Diagnostik und Therapie des Universitätsklinikums Charité, Berlin retrospektiv für den oben genannten Zeitraum 31 Patientinnen untersucht, bei deren Feten ein zystisches Nackenhygrom im Verlauf der Schwangerschaft diagnostiziert worden war. Ziel der Arbeit war es, die geeigneteste Therapieform in der Behandlung von lymphatischen Malformationen im Kindesalter in besonderen Hinsicht auf die Prognose, Rezidivfreiheit und Spätergebnisse zu untersuchen. Parallel galt es zu evaluieren, ob in Anbetracht der pränatalen Diagnostizierbarkeit lympahtischer Malformationen und dem postnatal sich daraus ergebenden Krankheitsverlauf eine Schwangerschaftsunterbrechung in Erwägung gezogen werden sollte.
A ten year retrospective study of 18 children with lymphatic malformation and 31 pregnant women with fetal cystic hygromas was carried out at the Department of Pediatric Surgery and the Department of Obstetrics and Gynaecology at the University Hospital Charité, Berlin. The objective of this study was to analyze the most effective therapy for lymphatic malformation in children with regard to the children prognosis, the recurrences after treatment and the long-time-follow-up. Another object to analyze was the point of prenatal diagnosis of fetal cystic hygromas and the adverse fetal outcome.

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27

Ndiaye, Papa Diogop. "Rôle et régulation du VEGF-C dans les cancers du rein à cellules claires." Thesis, Université Côte d'Azur (ComUE), 2017. http://www.theses.fr/2017AZUR4104/document.

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Le carcinome à cellules rénales (RCC) exprimant le facteur inductible de l'hypoxie (HIF) en raison de l'inactivation du gène de von Hippel Lindau (vhl), représente un modèle d'hypoxie chronique. Le devenir des patients dépend du stade de dissémination des cellules tumorales. Par conséquent, déchiffrer les mécanismes de métastase est une préoccupation majeure. Le développement dépendant du VEGF-C (Vascular Endothelial Growth Factor C) d'un réseau lymphatique est en première ligne de propagation métastatique. Pour étudier le rôle de VEGFC dans la dissémination du RCC, nous avons étudié son expression dans l'hypoxie et nous avons invalidé son gène dans des lignées cellulaires humaines et murines. L'hypoxie régule négativement l'ARNm de VEGFC par une diminution de la transcription et de la stabilité de l'ARNm mais l'expression de la protéine VEGF-C est induite par l’hypoxie. Des capacités accrues de prolifération et de migration, et une meilleure expression des marqueurs mésenchymateux et des marqueurs souches caractérisent les cellules vegf-c -/-. Alors que les cellules vegfc -/- ne forment pas de tumeurs chez les souris immunodéficientes, elles développent des tumeurs agressives chez les souris immunocompétentes. La surexpression de VEGFC, est liée à une augmentation de la survie sans progression et globale chez les patients atteints de tumeurs non métastatiques alors qu'une diminution de la survie sans progression et globale est observée chez les patients métastatiques. Nos expériences décrivent une régulation subtile du VEGF-C par hypoxie et mettent en évidence son rôle bénéfique ou péjoratif. Par conséquent, le ciblage VEGF-C pour la thérapie doit être considéré avec prudence
Hypoxic zones are common features of metastatic tumors. Renal cell carcinoma (RCC) expressing the Hypoxia Inducible Factor (HIF) because of inactivation of the von Hippel Lindau gene (vhl), represent models of chronic hypoxia. Their outcome depends on the extent of their dissemination at diagnosis. Therefore, deciphering the mechanisms of metastasis is a major concern. The Vascular Endothelial Growth Factor C (VEGFC)-dependent development of a lymphatic network is in front line of metastatic spreading. To address the role of VEGFC in RCC dissemination, we studied its expression in hypoxia and we invalidated its gene in human and mouse model cell lines of RCC. Hypoxia down-regulates VEGFC mRNA through a decrease in transcription and mRNA stability but concomitantly induced VEGFC protein expression. Increased proliferation and migration abilities, over-activation of the AKT signaling pathway and enhanced expression of mesenchymal and stem cell markers characterized vegfc-/- cells. Whereas vegfc-/- cells do not form tumors in immuno-deficient mice, they develop aggressive tumors in immuno-competent mice. Moreover, mouse RCC cells generate fast-growing tumors in mice invalidated for six1 or eya2, two major regulators of VEGFC expression. Lymphangiogenic markers overexpression including VEGFC is linked to increased disease-free and overall survival in patients with non-metastatic tumors whereas decreased progression-free and overall survival is observed for metastatic patients. Our experiments describe a subtle regulation of VEGFC by hypoxia and highlight its beneficial or pejorative role. Therefore, targeting VEGFC for therapy must be considered with caution

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28

Jamalian, Ardakani Seyedeh Samira 1987. "Modeling and Characterization of Lymphatic Vessels Using a Lumped Parameter Approach." Thesis, 2012. http://hdl.handle.net/1969.1/148276.

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The lymphatic system is responsible for several vital roles in human body, one of which is maintaining fluid and protein balance. There is no central pump in the lymphatic system and the transport of fluid against gravity and adverse pressure gradient is maintained by the extrinsic and intrinsic pumping mechanisms. Any disruption of the lymphatic system due to trauma or injury can lead to edema. There is no cure for lymphedema partly because the knowledge of the function of the lymphatic system is lacking. Thus, a well-developed model of the lymphatic system is crucial to improve our understanding of its function. Here we used a lumped parameter approach to model a chain of lymphangions in series. Equations of conservation of mass, conservation of momentum, and vessel wall force balance were solved for each lymphangion computationally. Due to the lack of knowledge of the parameters describing the system in the literature, more accurate measurements of these parameters should be pursued to advance the model. Because of the difficulty of the isolated vessel and in-situ experiments, we performed a parameter sensitivity analysis to determine the parameters that affect the system most strongly. Our results showed that more accurate estimations of active contractile force and physiologic features of lymphangions, such as length/diameter ratios, should be pursued in future experiments. Also further experiments are required to refine the valve behavior and valve parameters.

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29

Schnöink, Gerrit Sebastian. "Immunhistologische Charakterisierung experimenteller Lymphangiome der Maus." Doctoral thesis, 2009. http://hdl.handle.net/11858/00-1735-0000-0006-AF73-B.

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30

Blesinger, Hannah Leonore. "Untersuchung spezifischer Inhibitoren der PI3K-Signalkaskade zur Therapie des Lymphangioms." Doctoral thesis, 2020. http://hdl.handle.net/21.11130/00-1735-0000-0005-13FF-7.

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31

Schnöink, Gerrit Sebastian [Verfasser]. "Immunhistologische Charakterisierung experimenteller Lymphangiome der Maus / vorgelegt von Gerrit Sebastian Schnöink." 2009. http://d-nb.info/1002340810/34.

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32

Waldschmidt, Ulrike [Verfasser]. "Therapie der Lymphangiome im Kindesalter : Besonderheiten und Vorteile der Laserbehandlung / vorgelegt von Ulrike Waldschmidt." 2007. http://d-nb.info/988387239/34.

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33

Köster, Sven [Verfasser]. "Die chirurgische Versorgung cervikaler Lymphangiome im Kindesalter im Vergleich mit anderen Therapieverfahren / vorgelegt von Sven Köster." 2008. http://d-nb.info/988920980/34.

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34

Sommer, Oliver. "Das Lymphangiom im Kopf-Hals-Bereich : eine retrospektive Analyse von Behandlungsstrategien in der Universitätsklinik Köln und Vorstellung einer neune Lymphangiomklassifikation /." 2006. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=014835001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.

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