Academic literature on the topic 'Lymphatic System Disorders'

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Journal articles on the topic "Lymphatic System Disorders"

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Patil, A. R., S. Nandikoor, J. De Marco, R. Bhat, S. Shivakumar, and G. Mallrajapatna. "Disorders of the lymphatic system of the abdomen." Clinical Radiology 71, no. 10 (October 2016): 941–52. http://dx.doi.org/10.1016/j.crad.2016.06.116.

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Lee, Shimwoo, Aarti P. Luhar, Edward Wolfgang Lee, Sanjay Sinha, and Ravi N. Srinivasa. "Pediatric Lymphangiography: Imaging to Intervention." Digestive Disease Interventions 03, no. 03 (August 22, 2019): 203–13. http://dx.doi.org/10.1055/s-0039-1693414.

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AbstractThe lymphatic system plays a crucial role in fluid transport as well as facilitating immune recognition. Disruption of lymphatic flow can lead to significant morbidity and mortality in the pediatric population, manifesting as lymphatic malformations and lymphatic leaks. There has been rising interest in developing minimally invasive image-guided approaches to diagnose and treat lymphatic disorders in pediatric patients. Notably, magnetic resonance imaging of the lymphatic system has emerged as a promising diagnostic tool. Moreover, interventions such as sclerotherapy and thoracic duct embolization for treatment of lymphatic malformations and leaks have come forth as safe and effective alternatives to surgery. The aim of this article is to review various pediatric lymphatic disorders and discuss advances in image-guided diagnostic and therapeutic options for these entities.
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Hsu, M., and M. Itkin. "Lymphatic system flow disorders: novel imaging and interventional techniques." Journal of Vascular and Interventional Radiology 27, no. 3 (March 2016): S264. http://dx.doi.org/10.1016/j.jvir.2015.12.671.

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Patel, P. A., and A. M. Barnacle. "Re: Disorders of the lymphatic system of the abdomen." Clinical Radiology 72, no. 1 (January 2017): 91–92. http://dx.doi.org/10.1016/j.crad.2016.10.013.

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Yankova, G. S., and O. B. Bogomyakova. "Brain lymphatic drainage system – visualization opportunities and current state of the art." Complex Issues of Cardiovascular Diseases 9, no. 3 (September 28, 2020): 81–89. http://dx.doi.org/10.17802/2306-1278-2020-9-3-81-89.

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The lymphatic drainage system of the brain is assumed to consist of the lymphatic system and a network of meningeal lymphatic vessels. This system supports brain homeostasis, participates in immune surveillance and presents a new therapeutic target in the treatment of neurological disorders.The article analyzes and systematizes data on the brain lymphatic drainage system. The key components of this system are considered: recently described meningeal lymphatic vessels and their relationship with the glymphatic system, which provides perfusion of the central nervous system with cerebrospinal and interstitial fluids. The lymphatic drainage system helps to maintain water and ion balances of the interstitial fluid and to remove metabolic waste products, assists in reabsorption of macromolecules. Disorders in its work play a crucial role in age-related changes in the brain, the pathogenesis of neurovascular and neurodegenerative diseases, as well as injuries and brain tumors. The review also presents the results of human studies concerning the presence, anatomy and structure of meningeal lymphatic vessels and the glymphatic system. The discovery of the brain lymphatic drainage system has not only changed our understanding of cerebrospinal fluid circulation, but also contributed to understanding the pathology and mechanisms of neurodegenerative diseases.
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Patil, A. R. "Re: Disorders of the lymphatic system of the abdomen. A reply." Clinical Radiology 72, no. 1 (January 2017): 92. http://dx.doi.org/10.1016/j.crad.2016.10.012.

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Si, Hongjiang, Jian Wang, Cynthia J. Meininger, Xu Peng, David C. Zawieja, and Shenyuan L. Zhang. "Ca2+ release-activated Ca2+ channels are responsible for histamine-induced Ca2+ entry, permeability increase, and interleukin synthesis in lymphatic endothelial cells." American Journal of Physiology-Heart and Circulatory Physiology 318, no. 5 (May 1, 2020): H1283—H1295. http://dx.doi.org/10.1152/ajpheart.00544.2019.

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The lymphatic functions in maintaining lymph transport, and immune surveillance can be impaired by infections and inflammation, thereby causing debilitating disorders, such as lymphedema and inflammatory bowel disease. Histamine is a key inflammatory mediator known to trigger vasodilation and vessel hyperpermeability upon binding to its receptors and evoking intracellular Ca2+ ([Ca2+]i) dynamics for downstream signal transductions. However, the exact molecular mechanisms beneath the [Ca2+]i dynamics and the downstream cellular effects have not been elucidated in the lymphatic system. Here, we show that Ca2+ release-activated Ca2+ (CRAC) channels, formed by Orai1 and stromal interaction molecule 1 (STIM1) proteins, are required for the histamine-elicited Ca2+ signaling in human dermal lymphatic endothelial cells (HDLECs). Blockers or antagonists against CRAC channels, phospholipase C, and H1R receptors can all significantly diminish the histamine-evoked [Ca2+]i dynamics in lymphatic endothelial cells (LECs), while short interfering RNA-mediated knockdown of endogenous Orai1 or STIM1 also abolished the Ca2+ entry upon histamine stimulation in LECs. Furthermore, we find that histamine compromises the lymphatic endothelial barrier function by increasing the intercellular permeability and disrupting vascular endothelial-cadherin integrity, which is remarkably attenuated by CRAC channel blockers. Additionally, the upregulated expression of inflammatory cytokines, IL-6 and IL-8, after histamine stimulation was abolished by silencing Orai1 or STIM1 with RNAi in LECs. Taken together, our data demonstrated the essential role of CRAC channels in mediating the [Ca2+]i signaling and downstream endothelial barrier and inflammatory functions induced by histamine in the LECs, suggesting a promising potential to relieve histamine-triggered vascular leakage and inflammatory disorders in the lymphatics by targeting CRAC channel functions.
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Zulkharnain Tousheed, Syed. "Immune Response In Various Diffuse Parenchymal Lung Disorders (DPLDs)." Pulmonary Medicine and Respiratory Research 7, no. 3 (November 3, 2020): 1–8. http://dx.doi.org/10.24966/pmrr-0177/100046.

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Lung has one of the largest surface areas. It has to bear the brunt of infinite insults both from the airway and vascular end. The inhaled particles depending upon the size are cleared either by the luminal or the alveolar or the interstitial macrophages. The alveolar and interstitial macrophages clear the engulfed particles via the lymphatic system, which depends upon the blood perfusion. Most of the particles from the lower and middle lobes are cleared successfully, but the particle engulfed by macrophages in the upper lobe get trapped in the interstitium because of poor lymphatic supply.
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Burgard, C., R. Baumeister, F. Strobl, A. Rominger, P. Bartenstein, J. Wallmichrath, A. Frick, M. Notohamiprodjo, and M. Weiss. "Magnetic resonance imaging versus lymphoscintigraphy for the assessment of focal lymphatic transport disorders of the lower limb." Nuklearmedizin 53, no. 05 (2014): 190–96. http://dx.doi.org/10.3413/nukmed-0649-14-03.

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SummaryPurpose: To compare the diagnostic accuracy of magnetic resonance imaging (MR-lym- phangiography) and lymphoscintigraphy for assessment of focal lesions of the peripheral lymphatic system. Patients with focal lymphatic transport disorders might benefit from surgi-cal interventions. Patients, methods: We examined by lymphoscintigraphy and MR- lymphangiography a total of 85 lower limbs in 46 consecutive patients (33 women; mean age 41 years; range 9-79 years) presenting with uni- or bilateral lymphedema. MR-lym- phangiographies were obtained at isotropic sub-millimeter resolution with a 3.0 Tesla magnet after injection of gadolinium contrast medium. MR-lymphangiography was reviewed by radiologists, whereas lymp- hoscintigraphy was reviewed by nuclear medicine physicians. The images were examined for localization and distribution of any focal lesions of the lymphatic vessel system. Diagnostic accuracy of the MR-approach was calculated relative to the lymphoscintigraphy gold standard. Results: There was substantial correlation of results by the two modalities (κ = 0.62). MR-lymphangiography had sensitivity of 68%, specificity of 91%, positive predictive value of 82%, and negative predictive value of 83%. Conclusions: Imaging findings of both lymphoscintigraphy and MR-lymph- angiography showed good diagnostic accuracy. MR-lymphangiography proved more information about anatomic location of focal lesions of the lymphatic vessels, but use of MR-lymphangiography is currently constrained due to the requirement for off-label subcutaneous injection of gadolinium che- lates. Consequently, and due to its superior sensitivity lymphoscintigraphy remains the most common imaging method to assess functional lymphatic disorders of the lower limb.
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Korneva, Yu S., and R. V. Ukrainets. "The role of the cardiac lymphatic system in the development and progression of heart failure and novel therapeutic approaches for its management in post-infarction cardiac remodeling." Cardiovascular Therapy and Prevention 19, no. 3 (July 3, 2020): 2281. http://dx.doi.org/10.15829/1728-8800-2020-2281.

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Cardiac lymphatic vessels play a vital role in maintaining homeostasis in both physiological and pathological conditions, providing outflow of metabolites. It has been shown that myocardial infarction and postinfarction cardiac remodeling is accompanied by the lymphatic remodeling, which entails functional disorders and is of great importance in heart failure pathogenesis. As a result of progressive myocardial edema, hypoxia and fibrosis of the interstitial space increase, aggravating edema. Other pathways of additional myocardial damage and contractility reduction are triggered. Lymphatic efflux is associated with arrhythmias. Experimental models showed the positive effect of exogenous activation of lymphangiogenesis in relation to the prevention and treatment of heart failure, which can be further used to improve treatment regimens. This review discusses cardiac lymphatic remodeling after myocardial infarction, as well as the pathogenesis of related complications.
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Books on the topic "Lymphatic System Disorders"

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Waal, Isaac van der. Diseases of the salivary glands including dry mouth and Sjögren's syndrome: Diagnosis and treatment. Berlin: Springer-Verlag, 1996.

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Varicose veins, venous disorders, and lymphatic problems in the lower limbs. Oxford: Oxford University Press, 1997.

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S, Cody Hiram, ed. Sentinel lymph node biopsy. London: Martin Dunitz, 2002.

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Harrison, Jones undifferentiated, Barry M. Kinzbrunner, Schmidt undifferentiated, Giocobini, Kopelman, Serruys, et al. Sentinel Lymph Node Biopsy. Informa Healthcare, 2001.

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Sreebny, Leo M., and Isaac Van Der Waal. Diseases of the Salivary Glands: Including Dry Mouth and Sjogren's Syndrome Diagnosis and Treatment. Springer, 1997.

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Book chapters on the topic "Lymphatic System Disorders"

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Quizon, Annabelle, Edward Y. Lee, and Katie Krone. "Respiratory System Lymphatic Disorders." In Imaging in Pediatric Pulmonology, 283–91. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-23979-4_14.

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Olszewski, Waldemar L. "Anatomy of the Lymphatic System and Its Disorders." In Lymphedema, 49–56. London: Springer London, 2011. http://dx.doi.org/10.1007/978-0-85729-567-5_5.

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Bellini, Carlo, and Raoul CM Hennekam. "Clinical Disorders of Primary Malfunctioning of the Lymphatic System." In Developmental Aspects of the Lymphatic Vascular System, 187–204. Vienna: Springer Vienna, 2013. http://dx.doi.org/10.1007/978-3-7091-1646-3_14.

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Suami, Hiroo, and Seiji Kato. "Anatomy of the Lymphatic System and Its Structural Disorders in Lymphoedema." In Lymphedema, 57–78. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-52423-8_5.

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Swisher, Samantha, and Angela M. Lennox. "Disorders of the Haemic, Immunological and Lymphatic Systems." In Ferret Medicine and Surgery, 237–57. Taylor & Francis Group, 6000 Broken Sound Parkway NW, Suite 300, Boca Raton, FL 33487-2742: CRC Press, 2016. http://dx.doi.org/10.1201/9781315371504-17.

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Nair, Sanjiv, and Sunil S. Shroff. "Vascular Anomalies of the Oro-Maxillofacial Region." In Oral and Maxillofacial Surgery for the Clinician, 629–58. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-15-1346-6_31.

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AbstractVascular anomalies is a diverse group of disorders involving the vasculature (arteries,veins and lymphatics). These lesions in the head and neck can present since birth or later in life causing functional, cosmetic and bleeding problems. They can sometimes co-exist with a wide array of other pathologies and components of various syndromes. The different types, classifications, clinical features, imaging characteristics, treatment options and complications will be discussed in detail, with accordance to guidelines and principles in current literature. The author has designed a widely accepted anatomical classification for surgical management of these complex lesions, which is discussed in depth. Tailoring therapy depending on the anomaly is the key to successful treatment. Hemangiomas tend to proliferate and then involute , hence treated with systemic medication or alternate therapy for residual lesions. Vascular Malformations essentially would require aggressive management with surgery or embolisation and surgery. The concept of ‘corset suturing’ is explained and described, which is thought to be the ideal management for large venous malformations.
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Elokda, Ahmed Samir. "Lymphatic System Disorders." In Physical Rehabilitation, 718–32. Elsevier, 2007. http://dx.doi.org/10.1016/b978-072160361-2.50030-2.

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Mansour, Sahar, Silvia Martin-Almedina, and Pia Ostergaard. "Genetic Disorders of the Lymphatic System." In Emery and Rimoin's Principles and Practice of Medical Genetics and Genomics, 231–49. Elsevier, 2020. http://dx.doi.org/10.1016/b978-0-12-812532-8.00008-2.

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Gloviczki, Peter. "Development and anatomy of the venous system." In Handbook of Venous and Lymphatic Disorders, 15–26. CRC Press, 2017. http://dx.doi.org/10.1201/9781315382449-2.

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Stanaszek, Walter F., Mary J. Stanaszek, Robert J. Holt, and Steven Strauss. "The Lymphatic/Immune System and Its Disorders." In Understanding Medical Terms, 251–61. Routledge, 2020. http://dx.doi.org/10.4324/9780429273032-19.

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Conference papers on the topic "Lymphatic System Disorders"

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Pettys-Baker, Robert, Nicholas Schleif, J. Walter Lee, Sophia Utset-Ward, Mary Ellen Berglund, Lucy E. Dunne, Brad Holschuh, et al. "Tension-Controlled Active Compression Garment for Treatment of Orthostatic Intolerance." In 2018 Design of Medical Devices Conference. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/dmd2018-6884.

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Medical compression garments are used to treat lymphatic disorders or conditions of poor venous return (e.g. orthostatic intolerance). Conventional compression garments, namely elastic compression sleeves and inflatable compression systems, may aid in relief of these conditions but are also limited in usability. Fixed levels of compression in elastic materials may induce challenges in donning/doffing, complicating patient compliance [1]. Compression levels in inflatable systems are customizable, but these garments are also bulky and require a tethered inflation source [2]. We are interested in developing easy-to-don/-doff compression garments using shape memory alloy (SMA) coil actuators that contract with heat from an applied current which can be wrapped around the body to apply compressive forces. More specifically, we use a spring coil formation as described by Holschuh et al. [3]. Further developed in the Wearable Technology Lab at the University of Minnesota, our current SMA compression garment (SMA-CG) design improves upon the work of Duvall et al. [4] presented in previous year’s (2017) Design of Medical Devices Conference, representing a year’s evolution in active compression garment design that integrate actuators made with SMA.
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