Relevant bibliographies by topics / Lymphatic System, drug effects

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Lymphatic System, drug effects'

Author: Grafiati
Published: 4 June 2021
Last updated: 30 January 2023

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Journal articles on the topic "Lymphatic System, drug effects"

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Ye, Jun, Yue Gao, Ming Ji, Yanfang Yang, Zhaohui Wang, Baolian Wang, Jing Jin, et al. "Oral SMEDDS promotes lymphatic transport and mesenteric lymph nodes target of chlorogenic acid for effective T-cell antitumor immunity." Journal for ImmunoTherapy of Cancer 9, no. 7 (July 2021): e002753. http://dx.doi.org/10.1136/jitc-2021-002753.

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BackgroundMesenteric lymph nodes (MLNs) are critical draining lymph nodes of the immune system that accommodate more than half of the body’s lymphocytes, suggesting their potential value as a cancer immunotherapy target. Therefore, efficient delivery of immunomodulators to the MLNs holds great potential for activating immune responses and enhancing the efficacy of antitumor immunotherapy. Self-microemulsifying drug delivery systems (SMEDDS) have attracted increasing attention to improving oral bioavailability by taking advantage of the intestinal lymphatic transport pathway. Relatively little focus has been given to the lymphatic transport advantage of SMEDDS for efficient immunomodulators delivery to the MLNs. In the present study, we aimed to change the intestinal lymphatic transport paradigm from increasing bioavailability to delivering high concentrations of immunomodulators to the MLNs.MethodsChlorogenic acid (CHA)-encapsulated SMEDDS (CHA-SME) were developed for targeted delivery of CHA to the MLNs. The intestinal lymphatic transport, immunoregulatory effects on immune cells, and overall antitumor immune efficacy of CHA-SME were investigated through in vitro and in vivo experiments.ResultsCHA-SME enhanced drug permeation through intestinal epithelial cells and promoted drug accumulation within the MLNs via the lymphatic transport pathway. Furthermore, CHA-SME inhibited tumor growth in subcutaneous and orthotopic glioma models by promoting dendritic cell maturation, priming the naive T cells into effector T cells, and inhibiting the immunosuppressive component. Notably, CHA-SME induced a long-term immune memory effect for immunotherapy.ConclusionsThese findings indicate that CHA-SME have great potential to enhance the immunotherapeutic efficacy of CHA by activating antitumor immune responses.
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Jang, Ji-Hun, Seung-Hyun Jeong, and Yong-Bok Lee. "Preparation and In Vitro/In Vivo Characterization of Polymeric Nanoparticles Containing Methotrexate to Improve Lymphatic Delivery." International Journal of Molecular Sciences 20, no. 13 (July 5, 2019): 3312. http://dx.doi.org/10.3390/ijms20133312.

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Methotrexate (MTX) is a folic acid antagonist used as an effective drug to treat various kinds of cancers. However, MTX has limited use in cancer chemotherapy due to its adverse effects such as poor bioavailability, low specificity, drug resistance, and dose-dependent side effects. To improve lymphatic delivery and reduce toxicity of MTX, MTX-loaded nanoparticles (NPs) were prepared in the present study. NPs were prepared with double emulsion solvent evaporation method using poly(lactide-co-glycolide) (PLGA). NPs were assessed for size, encapsulation efficiency, morphology, Fourier-transform infrared spectroscopy, X-ray diffraction, and thermal characterization. In vitro release profiles and cytotoxicity of these NPs were also evaluated. Prepared NPs and free MTX were administered orally or intravenously (5 mg/kg as MTX) to rats to evaluate their pharmacokinetic characteristics and lymphatic delivery effects. Mean particle size and encapsulation efficiency of NPs were 163.7 ± 10.25 nm and 93.3 ± 0.5%, respectively. Prepared NPs showed a sustained release profile of MTX in vitro and may be effective to cancer cells. Area under the blood concentration-time curve, total clearance, half-life, and lymphatic targeting efficiency were significantly different (p < 0.05) between prepared NPs and free MTX. These results demonstrate that MTX-loaded PLGA NPs are good candidates for targeted delivery of MTX to the lymphatic system.
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Kadian, Renu, and Arun Nanda. "A Comprehensive Insight on Self Emulsifying Drug Delivery Systems." Recent Advances in Drug Delivery and Formulation 16, no. 1 (April 2022): 15–43. http://dx.doi.org/10.2174/2667387815666211207112803.

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Background: The oral route is a highly recommended route for the delivery of a drug. But most lipophilic drugs are difficult to deliver via this route due to their low aqueous solubility. Selfemulsifying drug delivery systems (SEDDS) have emerged as a potential approach of increasing dissolution of a hydrophobic drug due to spontaneous dispersion in micron or nano sized globules in the GI tract under mild agitation. Objective: The main motive of this review article is to describe the mechanisms, advantages, disadvantages, factors affecting, effects of excipients, possible mechanisms of enhancing bioavailability, and evaluation of self-emulsifying drug delivery systems. Result: Self emulsifying systems incorporate the hydrophobic drug inside the oil globules, and a monolayer is formed by surfactants to provide the low interfacial tension, which leads to improvement in the dissolution rate of hydrophobic drugs. The globule size of self-emulsifying systems depends upon the type and ratio of excipients in which they are used. The ternary phase diagram is constructed to find out the range of concentration of excipients used. This review article also presents recent and updated patents on self-emulsifying drug delivery systems. Self-emulsifying systems have the ability to enhance the oral bioavailability and solubility of lipophilic drugs. Conclusion: This technique offers further advantages such as bypassing the first pass metabolism via absorption of drugs through the lymphatic system, easy manufacturing, reducing enzymatic hydrolysis, inter and intra subject variability, and food effects.
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Agrawal, Shivanshu, Anuj Garg, and Vikas Varshney. "Recent Updates On Applications of Lipid-Based Nanoparticles For Site- Specific Drug Delivery." Pharmaceutical Nanotechnology 10, no. 1 (February 2022): 24–41. http://dx.doi.org/10.2174/2211738510666220304111848.

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Background: Site-specific drug delivery is a widespread and demanding area nowadays. Lipid-based nanoparticulate drug delivery systems have shown promising effects for targeting drugs among lymphatic systems, brain tissues, lungs, and skin. Recently, lipid nanoparticles are used for targeting the brain via the mucosal route for local therapeutic effects. Lipid nanoparticles (LNPs) can help in enhancing the efficacy and lowering the toxicities of anticancer drugs to treat the tumors, particularly in lymph after metastases of tumors. LNPs contain a non-polar core that can improve the absorption of lipophilic drugs into the lymph node and treat tumors. Cellular uptake of drugs can also be enhanced using LNPs and therefore, LNPs are the ideal carrier for treating intracellular infections such as leishmaniasis, tuberculosis and parasitic infection in the brain, etc. Furthermore, specific surface modifications with molecules like mannose, or PEG could improve the macrophage uptake and hence effectively eradicate parasites hiding in macrophages. Method: An electronic literature search was conducted to update the advancements in the field of site-specific drug delivery utilizing lipid-based nanoparticles. A search of the Scopus database (https://www.scopus.com/home.uri) was conducted using the following keywords: lipid-based nanoparticles; site specific delivery. Conclusion: Solid lipid nanoparticles have shown site-specific targeted delivery to various organs including the liver, oral mucosa, brain, epidermis, pulmonary and lymphatic systems. These lipid-based systems showed improved bioavailability as well as reduced side effects. Therefore, the focus of this article is to review the recent research studies on LNPs for site-specific or targeting drug delivery.
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Cribb, Matthew T., Lauren F. Sestito, Stanley G. Rockson, Mark R. Nicolls, Susan N. Thomas, and J. Brandon Dixon. "The Kinetics of Lymphatic Dysfunction and Leukocyte Expansion in the Draining Lymph Node during LTB4 Antagonism in a Mouse Model of Lymphedema." International Journal of Molecular Sciences 22, no. 9 (April 24, 2021): 4455. http://dx.doi.org/10.3390/ijms22094455.

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The mechanisms of lymphedema development are not well understood, but emerging evidence highlights the crucial role the immune system plays in driving its progression. It is well known that lymphatic function deteriorates as lymphedema progresses; however, the connection between this progressive loss of function and the immune-driven changes that characterize the disease has not been well established. In this study, we assess changes in leukocyte populations in lymph nodes within the lymphatic drainage basin of the tissue injury site (draining lymph nodes, dLNs) using a mouse tail model of lymphedema in which a pair of draining collecting vessels are left intact. We additionally quantify lymphatic pump function using established near infrared (NIR) lymphatic imaging methods and lymph-draining nanoparticles (NPs) synthesized and employed by our team for lymphatic tissue drug delivery applications to measure lymphatic transport to and resulting NP accumulation within dLNs associated with swelling following surgery. When applied to assess the effects of the anti-inflammatory drug bestatin, which has been previously shown to be a possible treatment for lymphedema, we find lymph-draining NP accumulation within dLNs and lymphatic function to increase as lymphedema progresses, but no significant effect on leukocyte populations in dLNs or tail swelling. These results suggest that ameliorating this loss of lymphatic function is not sufficient to reverse swelling in this surgically induced disease model that better recapitulates the extent of lymphatic injury seen in human lymphedema. It also suggests that loss of lymphatic function during lymphedema may be driven by immune-mediated mechanisms coordinated in dLNs. Our work indicates that addressing both lymphatic vessel dysfunction and immune cell expansion within dLNs may be required to prevent or reverse lymphedema when partial lymphatic function is sustained.
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Király, Gábor, John Chinonso Egu, Zoltán Hargitai, Ilona Kovács, István Fábián, József Kalmár, and Gábor Szemán-Nagy. "Mesoporous Aerogel Microparticles Injected into the Abdominal Cavity of Mice Accumulate in Parathymic Lymph Nodes." International Journal of Molecular Sciences 22, no. 18 (September 9, 2021): 9756. http://dx.doi.org/10.3390/ijms22189756.

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Mesoporous aerogel microparticles are promising drug delivery systems. However, their in vivo biodistribution pathways and health effects are unknown. Suspensions of fluorescein-labeled silica–gelatin hybrid aerogel microparticles were injected into the peritoneum (abdominal cavity) of healthy mice in concentrations of 52 and 104 mg kg−1 in a 3-week-long acute toxicity experiment. No physiological dysfunctions were detected, and all mice were healthy. An autopsy revealed that the aerogel microparticles were not present at the site of injection in the abdominal cavity at the end of the experiment. The histological study of the liver, spleen, kidneys, thymus and lymphatic tissues showed no signs of toxicity. The localization of the aerogel microparticles in the organs was studied by fluorescence microscopy. Aerogel microparticles were not detected in any of the abdominal organs, but they were clearly visible in the cortical part of the parathymic lymph nodes, where they accumulated. The accumulation of aerogel microparticles in parathymic lymph nodes in combination with their absence in the reticuloendothelial system organs, such as the liver or spleen, suggests that the microparticles entered the lymphatic circulation. This biodistribution pathway could be exploited to design passive targeting drug delivery systems for flooding metastatic pathways of abdominal cancers that spread via the lymphatic circulation.
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White, D. G., M. J. Story, and S. G. Barnwell. "An experimental animal model for studying the effects of a novel lymphatic drug delivery system for propranolol." International Journal of Pharmaceutics 69, no. 2 (March 1991): 169–74. http://dx.doi.org/10.1016/0378-5173(91)90221-9.

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Lala, Rita R., Amol S. Shinde, and Nikita Y. Nandvikar. "SOLID LIPID NANOPARTICLES: A PROMISING APPROACH FOR COMBINATIONAL DRUG THERAPY IN CANCER." International Journal of Applied Pharmaceutics 10, no. 5 (September 8, 2018): 17. http://dx.doi.org/10.22159/ijap.2018v10i5.27894.

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Combination therapy for cancer treatment is accepted worldwide due to the generation of synergistic anticancer effects; restrain in multidrug resistance (MDR) or tumor resistance by different mechanisms of action and minimization of dose-dependent toxicity. Recently developed Solid lipid nanoparticles (SLNs) are matrix composed of lipid which is solid at both room and body temperature and hence it is as an alternative to other nanocarrier systems. SLNs after oral administration get absorbed by lymphatic pathway due to stimulation of chylomicron formation. Thus, it avoids all consequences related to an oral drug delivery system and improves oral bioavailability. SLNs based combination drug delivery to tumor tissues reduces the problems associated with chemotherapy. The targeted and sustained delivery of chemotherapeutic agents reduces the dose by achieving high concentrations at the target site, without altering the normal tissues. In this article, we have reviewed and focused on SLNs as a drug delivery system; ingredients used in formulating SLNs and developed two or more drugs in a single formulation of SLNs as drug delivery. This article also focuses on the fact that SLNs as a combination drug delivery provides an attractive approach in future prevention and beneficial for the treatment of cancer by increasing its therapeutic efficacy.
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Gausuzzaman, Syed Abul Layes, Mithun Saha, Shahid Jaman Dip, Shaiful Alam, Arup Kumar, Harinarayan Das, Shazid Md Sharker, Md Abdur Rashid, Mohsin Kazi, and Hasan Mahmud Reza. "A QbD Approach to Design and to Optimize the Self-Emulsifying Resveratrol–Phospholipid Complex to Enhance Drug Bioavailability through Lymphatic Transport." Polymers 14, no. 15 (August 8, 2022): 3220. http://dx.doi.org/10.3390/polym14153220.

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Objectives: Despite having profound therapeutic value, the clinical application of resveratrol is restrained due to its <1% bioavailability, arising from the extensive fast-pass effect along with enterohepatic recirculation. This study aimed to develop a self-emulsifying formulation capable of increasing the bioavailability of resveratrol via lymphatic transport. Methods: The resveratrol–phospholipid complex (RPC) was formed by the solvent evaporation method and characterized by FTIR, DSC, and XRD analyses. The RPC-loaded self-emulsifying drug delivery system (SEDDS) was designed, developed, and optimized using the QbD approach with an emphasis on resveratrol transport through the intestinal lymphatic pathway. The in vivo pharmacokinetic study was investigated in male Wister Albino rats. Results: The FTIR, DSC, and XRD analyses confirmed the RPC formation. The obtained design space provided robustness of prediction within the 95% prediction interval to meet the CQA specifications. An optimal formulation (desirability value of 7.24) provided Grade-A self-emulsion and exhibited a 48-fold bioavailability enhancement compared to the pure resveratrol. The cycloheximide-induced chylomicron flow blocking approach demonstrated that 91.14% of the systemically available resveratrol was transported through the intestinal lymphatic route. Conclusions: This study suggests that an optimal self-emulsifying formulation can significantly increase the bioavailability of resveratrol through lymphatic transport to achieve the desired pharmacological effects.
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Amri, Nada, Rémi Bégin, Nolwenn Tessier, Laurent Vachon, Louis Villeneuve, Philippe Bégin, Renée Bazin, Lionel Loubaki, and Catherine Martel. "Use of Early Donated COVID-19 Convalescent Plasma Is Optimal to Preserve the Integrity of Lymphatic Endothelial Cells." Pharmaceuticals 15, no. 3 (March 17, 2022): 365. http://dx.doi.org/10.3390/ph15030365.

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Convalescent plasma therapy (CPT) has gained significant attention since the onset of the coronavirus disease 2019 (COVID-19) pandemic. However, clinical trials designed to study the efficacy of CPT based on antibody concentrations were inconclusive. Lymphatic transport is at the interplay between the immune response and the resolution of inflammation from peripheral tissues, including the artery wall. As vascular complications are a key pathogenic mechanism in COVID-19, leading to inflammation and multiple organ failure, we believe that sustaining lymphatic vessel function should be considered to define optimal CPT. We herein sought to determine what specific COVID-19 convalescent plasma (CCP) characteristics should be considered to limit inflammation-driven lymphatic endothelial cells (LEC) dysfunction. CCP donated 16 to 100 days after the last day of symptoms was characterized and incubated on inflammation-elicited adult human dermal LEC (aHDLEC). Plasma analysis revealed that late donation correlates with higher concentration of circulating pro-inflammatory cytokines. Conversely, extracellular vesicles (EVs) derived from LEC are more abundant in early donated plasma (r = −0.413, p = 0.004). Thus, secretion of LEC-EVs by an impaired endothelium could be an alarm signal that instigate the self-defense of peripheral lymphatic vessels against an excessive inflammation. Indeed, in vitro experiments suggest that CCP obtained rapidly following the onset of symptoms does not damage the aHDLEC junctions as much as late-donated plasma. We identified a particular signature of CCP that would counteract the effects of an excessive inflammation on the lymphatic endothelium. Accordingly, an easy and efficient selection of convalescent plasma based on time of donation would be essential to promote the preservation of the lymphatic and immune system of infected patients.
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Dissertations / Theses on the topic "Lymphatic System, drug effects"

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Hawley, Ann Elizabeth. "The uptake of nanospheres by the lymphatic system." Thesis, University of Nottingham, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.307765.

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Schwab, Anne Elisabeth. "The genetics of potential albendazole and ivermectin resistance in lymphatic filariae /." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=103006.

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A current initiative to eliminate lymphatic filariasis (LF), headed by the World Health Organization, aims to interrupt transmission of the disease through yearly community-wide treatment with the broad spectrum anthelmintic albendazole (ABZ), in combination with ivermectin (IVM) or diethylcarbamazine (DEC). Over the years, the use of both ABZ and IVM in the treatment of veterinary parasites has led to widespread anthelmintic resistance against these drugs. In this study, we genotyped microfilaria of Wuchereria bancrofti, a causative agent of LF, in order to detect the presence of mutations which confer ABZ resistance in other parasites, and we identified such mutations in worms obtained from untreated patients in Ghana and Burkina Faso, West Africa. Microfilaria from patients who had been treated with ABZ + IVM, had a significantly higher frequency of the resistant genotype, and this frequency was even higher in worms from patients that had received two rounds of treatment. In addition, the untreated population of microfilaria had an excess of homozygotes in the population. This excess homozygosity was equivalent to a Wright's Inbreeding Statistic of FIT= 0.44, and we found that the population was significantly subdivided between patients. In order to better understand the mechanisms and factors involved in the potential spread of ABZ resistance, caused by such mutations, through a population of Culex-transmitted W. bancrofti, we developed a deterministic model that incorporates genotype structure into the epidemiological model EPIFIL. This model predicts that the combination of ABZ + DEC leads to stronger selection for the resistant genotype than ABZ + IVM, and that drug efficacy assumptions are an important factor affecting the spread of drug resistance. Treatment coverage, non-random mating, initial allele frequency and number of treatments also had substantial impact on the speed and magnitude of the spread of ABZ resistance. When we expanded this model to include potential IVM-resistance alleles we found that, under ABZ + IVM treatment, selection for resistance to either drug is enhanced by the presence of resistance against the second drug. Similarly, excess homozygosity caused by parasite non-random mating may increase selection for a dominant IVM resistance allele through enhancing the spread of a recessive ABZ resistance allele. Resistence developed more slowly when it was inherited as a polygenic trait. Results from this study suggest that resistance monitoring is crucial, as resistance may not be apparent until treatment is stopped, recrudescence occurs and treatment is reapplied.
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Dickstein, Jodi B. "The effects of sleep and tumour necrosis factor-Ã on the lymphatic system." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape8/PQDD_0021/NQ45754.pdf.

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Nguyen, Vu Xuan 1957. "Drug surveillance system for type B adverse effects: a vision." Thesis, McGill University, 1995. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=22865.

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Since type B adverse drug reactions tend to be rare and serious, they tend to be treated by tertiary-care specialists; and since they are commonly iatrogenic, the specialists should be concerned to document carefully not only the case per se but also the drug use history, leading to practice data of good research quality. The specialist should also be concerned to submit the data record to a central facility that would supply the probabilities, evidence-based, that a recent drug use by a patient caused the adverse event. Continual and systematic accumulation of these data records at the central facility--using the same logistic and organizational framework for each of different type B events--provides for both the numerator and denominator series for etiologic research. Since the targeted events are quite rare, the catchment population of the "registry" would have to be very large, international in scope, especially if the system is to provide for rapid resolution of crises arising from novel suspicions of type B effects with respect to newly marketed drugs.
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Sandin, Johan. "The hippocampal opioid system : role in spatial learning /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4332-x/.

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Wanecek, Michael. "The endothelin system and cardiopulmonary dysfunction in porcine endotoxin shock /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3707-9/.

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Johnson, Hans. "Spinal motoneurons and the bulbospinal serotoninergic system in aged rats with behavioral deficits /." Stockholm, 1998. http://diss.kib.ki.se/1998/91-628-3277-8/.

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Kechagias, Stergios. "Clinical pharmacokinetics of small doses of ethanol : role of gastric emptying and other influences in the upper gastrointestinal tract /." Linköping : Univ, 2001. http://www.bibl.liu.se/liupubl/disp/disp2001/med682s.pdf.

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Olgart, Caroline. "Studies on nitric oxide in autonomic neurotransmission /." Stockholm, 1998. http://diss.kib.ki.se/1998/91-628-2961-0.

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Jagadeesan, Sasi Kumar. "Experimental Approach for Drug Profiling of Calcitriol in Yeast." Thesis, Université d'Ottawa / University of Ottawa, 2016. http://hdl.handle.net/10393/34617.

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Vitamin D regulation is associated with several human disorders and contributes to various cellular mechanisms. Calcitriol (commercially available as Rocaltrol), an active Vitamin D metabolite, is known as a neuro-protective and anti-cancer drug but most importantly helps maintaining the calcium homeostasis inside the human body. The effectiveness of calcitriol to perform as an effective therapeutic agent is counteracted by its calcemic effects. In order to obtain better therapeutic results, synthetic calcitriol analogs without these calcemic effects have been recently developed but they are not yet cost-effective and their production is time-consuming. In order to determine the best active form of calcitriol that could provide higher chemotherapeutic activity without these calcemic effects, calcitriol mode of action was studied using yeast as a model system. In order to achieve this, we analyzed the calcitriol effects on yeast cellular growth based on calcium intake levels. In this work, we also assessed yeast strains with gene deletions of selected calcium transporter genes to understand the calcitriol metabolism. For the aim of understanding hypercalcemic effects of calcitriol, we developed a hypothesis based on calcitriol interactions with oxygen. Interestingly, use of an anaerobic model validated the oxygen interactions with calcitriol that might possibly cause calcemic effects on patients. Anaerobically grown yeast treated with calcitriol showed significantly less intracellular calcium levels when imaged under indo-1 calcium binding fluorescence dye as compared to calcitriol treated yeast grown under aerobic conditions. Finally, we predict that calcitriol might control free radical generation within the yeast system based on experiments with AAPH and UV- irradiation.
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Books on the topic "Lymphatic System, drug effects"

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Leong, Stanley P. L. From local invasion to metastatic cancer: Involvement of distant sites through the lymphovascular system. New York: Humana, 2009.

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The effects of drug abuse on the human nervous system. Amsterdam: Elsevier, 2014.

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J, Peroutka Stephen, ed. Ecstasy: The clinical, pharmacological, and neurotoxicological effects of the drug MDMA. Boston: Kluwer Academic Publishers, 1990.

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B, Abou-Donia Mohamed, ed. Neurotoxicology. Boca Raton: CRC Press, 1992.

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Drug action in the central nervous system. New York: Oxford University Press, 1998.

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Ryall, Ronald W. Mechanisms of drug action on the nervous system. 2nd ed. Cambridge [England]: Cambridge University Press, 1989.

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Introduction to neuropharmacology. London: Wright, 1989.

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BGA-Symposium "On the Problems of Drug Related Damage to the Respiratory Tract" (1985 Berlin, Germany). Drug-related damage to the respiratory tract. Edited by Grosdanoff P and Hebold Gottfried. München: MMV Medizin, 1986.

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Pang, Catherine C. Y. The effects of drugs on the venous system. Austin: R.G. Landes, 1994.

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Frank, Austen K., ed. Therapeutic immunology. Cambridge, Mass., USA: Blackwell Science, 1996.

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Book chapters on the topic "Lymphatic System, drug effects"

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Yang, Qiuhong, and Laird Forrest. "Drug Delivery to the Lymphatic System." In Drug Delivery, 503–48. Hoboken, NJ: John Wiley & Sons, Inc, 2016. http://dx.doi.org/10.1002/9781118833322.ch21.

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Desai, Jagruti L., and Hetal P. Thakkar. "Role of Lipid Nanocarriers in Lymphatic Targeting: Promises and Safety Considerations." In Nanocarriers: Drug Delivery System, 43–59. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-33-4497-6_2.

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Wu, Fang, Hong Ding, and Zhirong Zhang. "Antibody-Mediated Drug Delivery System for Lymphatic Targeting Treatment." In Antibody-Mediated Drug Delivery Systems, 169–90. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2012. http://dx.doi.org/10.1002/9781118229019.ch9.

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Hall, J. G. "The Lymphatic System in Drug Targeting: An Overview." In Targeting of Drugs, 15–28. Boston, MA: Springer US, 1988. http://dx.doi.org/10.1007/978-1-4684-5574-8_2.

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Jain, Kewal K. "Adverse Effects of Biological Therapies on the Nervous System." In Drug-induced Neurological Disorders, 145–54. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-73503-6_10.

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Jain, Kewal K. "Adverse Effects of Drugs on the Fetal Nervous System." In Drug-induced Neurological Disorders, 55–78. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-73503-6_5.

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Jain, Vishal, T. S. Dharmarajan, and C. S. Pitchumoni. "Drug Effects on the Gastrointestinal System: A Physician Perspective." In Geriatric Gastroenterology, 1–18. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-319-90761-1_9-1.

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Jain, Vishal, T. S. Dharmarajan, and C. S. Pitchumoni. "Drug Effects on the Gastrointestinal System: A Physician Perspective." In Geriatric Gastroenterology, 279–96. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-30192-7_9.

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Goriacko, Pavel, and Keith T. Veltri. "Adverse Drug Effects Involving the Gastrointestinal System (Pharmacist Perspective)." In Geriatric Gastroenterology, 297–339. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-30192-7_10.

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Goriacko, Pavel, and Keith T. Veltri. "Adverse Drug Effects Involving the Gastrointestinal System (Pharmacist Perspective)." In Geriatric Gastroenterology, 1–44. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-319-90761-1_10-1.

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Conference papers on the topic "Lymphatic System, drug effects"

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"Lymphatic targeting drug delivery system and tumor treatment." In 2018 International Conference on Medicine, Biology, Materials and Manufacturing. Francis Academic Press, 2018. http://dx.doi.org/10.25236/icmbmm.2018.73.

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Mishra, Radhika, Ariunbuyan Sukhbaatar, Sora Shouta, Maya Sakamoto, Shiro Mori, and Tetsuya Kodama. "Abstract LBA051: Importance of drug osmotic pressure and viscosity for efficient drug delivery using lymphatic drug delivery system." In Abstracts: AACR-NCI-EORTC Virtual International Conference on Molecular Targets and Cancer Therapeutics; October 7-10, 2021. American Association for Cancer Research, 2021. http://dx.doi.org/10.1158/1535-7163.targ-21-lba051.

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Kodama, Tetsuya, and Shiro Mori. "Abstract 2005: Optimized range of osmotic pressure and viscosity for a lymphatic drug delivery system." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-2005.

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Kodama, Tetsuya, and Shiro Mori. "Abstract 2005: Optimized range of osmotic pressure and viscosity for a lymphatic drug delivery system." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-2005.

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Rahbar, Elaheh, Tony Akl, David C. Zawieja, Gerard L. Cote, and James E. Moore. "Effects of Edemagenic Stress on Lymph Transport in the Rat Mesentery." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53466.

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The lymphatic system transports fluid from the interstitium into the vascular network of lymphatic vessels through a series of valves, nodes and post-nodal ducts that converge into the subclavian veins. The lymphatics are intimately involved in fluid circulation, macromolecular homeostasis, lipid absorption, and immune function. All of these functions rely on the generation and regulation of lymph flow along the collecting lymphatic vessels. An imbalance between the lymphatic load and the ability to transport lymph can lead to lymphedema. Lymphedema occurs with a pathological increased in load, impaired vasculature (either anatomically or functionally deranged), or in situations where there is a relative distortion of both factors [1]. Edema has become a growing concern amongst breast cancer patients; surveys have reported up to 90% of women develop lymphedema in their arms within 3 years of nodal dissection surgery [2]. Despite these statistics, our knowledge of edema remains very basic and thus there is a lack of effective treatment.
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Galeano, Diego, and Alberto Paccanaro. "A Recommender System Approach for Predicting Drug Side Effects." In 2018 International Joint Conference on Neural Networks (IJCNN). IEEE, 2018. http://dx.doi.org/10.1109/ijcnn.2018.8489025.

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Wu, Hao, Hui Fang, and Steven J. Stanhope. "An early warning system for unrecognized drug side effects discovery." In the 21st international conference companion. New York, New York, USA: ACM Press, 2012. http://dx.doi.org/10.1145/2187980.2188068.

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Kitajima, Shiho, Rafal Rzepka, and Kenji Araki. "Performance Improvement of Drug Effects Extraction System from Japanese Blogs." In 2013 IEEE Seventh International Conference on Semantic Computing (ICSC). IEEE, 2013. http://dx.doi.org/10.1109/icsc.2013.71.

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Kwak, Bongseop, Kinam Park, and Bumsoo Han. "Tumor-on-Chip: Simulation of Complex Transport Around Tumor." In ASME 2013 2nd Global Congress on NanoEngineering for Medicine and Biology. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/nemb2013-93314.

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Nanoparticles (NP) offer great potential as drug carriers for targeted delivery to tumor by increasing the delivery efficacy and reducing non-specific accumulation at non-targeted sites [1]. Despite these promising early outcomes [2], the NP delivery to target tumor site is still significantly limited due to complex in vivo transport barriers [3–5]. In order to improve the in vivo delivery efficacy, the NPs should be designed considering all these complex transport barriers beyond currently used enhanced permeation and retention (EPR) effect [6]. However, testing of NP delivery are primarily based on simple 2D or 3D in vitro cell cultures or animal models. However, these static 2D or 3D tumor models oversimplify the actual in vivo tumor environment including the absence of tissue-tissue interactions such as blood-endothelium, endothelium-intersititum, high interstitial fluid pressure, and interstitium-lymphatics [2, 3]. The animal models can provide the testbed with these tissue-tissue interactions, but it is very difficult to establish quantitative understanding of the NP transport at these tissue-tissue interfaces. To address these challenges and bridge the in vitro static models with the animal models, here we developed a 3D multi-layered microfluidic system that mimics the tissue-tissue interactions at tumor microenvironment is developed. The system is then used to investigate the transvascular and interstitial transport of NPs in tumor.
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Wang, Siling, Tongying Jang, and Zhanyou Wang. "Permeability and Anticataract Effects of a Topical Ocular Drug Delivery System of Disulfiram." In 2008 International Conference on Biomedical Engineering And Informatics (BMEI). IEEE, 2008. http://dx.doi.org/10.1109/bmei.2008.115.

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Reports on the topic "Lymphatic System, drug effects"

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Mery, Laura, Matthew Wayner, John McQuade, and Erica Anderson. Characterization of the Effects of Fatigue on the Central Nervous System (CNS) and Drug Therapies. Fort Belvoir, VA: Defense Technical Information Center, November 2007. http://dx.doi.org/10.21236/ada489794.

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Ciapponi, Agustín. What are the effects of reference pricing and other pharmaceutical pricing and purchasing policies? SUPPORT, 2016. http://dx.doi.org/10.30846/1608143.

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Pharmaceutical pricing and purchasing policies are used to determine or affect the prices that are paid for drugs. This review found evidence for reference pricing, index pricing, and maximum prices. In reference pricing a reference drug is chosen amongst identical or similar medicines or therapeutically equivalent and the price of the reference drug is reimbursed for all the drugs in that group of drugs. For drugs that are more expensive than the reference drug, the patient has to pay the cost above the reference price. An index price is the maximum refundable price to pharmacies for drugs within an index group of therapeutically interchangeable drugs. A maximum price is a fixed price that attempts to secure pharmaceutical prices that are considered ‘reasonable’ for a given health system.
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Wu, Xiaoqi, Maoxia Fan, Yaobo Pan, and Dona Guo. Quality of Evidence Supporting the Effects of Ginkgo Terpene Lactone Preparations in Ischemic Stroke: An Overview of Systematic Reviews and Meta-Analyses. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, September 2022. http://dx.doi.org/10.37766/inplasy2022.9.0124.

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Review question / Objective: 2.2.1 Type of studies SRs/MAs of Randomized Controlled Trials (RCTs) of GTLP for IS in any language. 2.2.2 Type of Participants Included patients were diagnosed with IS according to international or national standards, regardless of race, age, gender, time of onset, and source of cases. 2.2.3 Type of Intervention The intervention method in the control group was routine treatment, and the intervention method in the intervention group was GTLP treatment or GTLP combined with the treatment of the control group. 2.2.4 Types of outcomes Conclusions at least need to include clinical efficacy analysis and National Institute of Health Stroke Scale (NIHSS). Condition being studied: Stroke is the second leading cause of death and third leading cause of disability globally.Among them, ischemic stroke (IS) accounts for 70% of all stroke types. It is a central nervous system disease caused by cerebral blood circulation disorder, ischemia and hypoxia .The incidence rate is high and increasing year by year, the age of onset is younger, the disability rate is high, and most patients have different degrees of limb motor dysfunction.In order to reduce the burden of stroke on the society and the patient's family, many articles proposed to strengthen the primary stroke prevention - behavior change and drug intervention.
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Cahaner, Avigdor, Susan J. Lamont, E. Dan Heller, and Jossi Hillel. Molecular Genetic Dissection of Complex Immunocompetence Traits in Broilers. United States Department of Agriculture, August 2003. http://dx.doi.org/10.32747/2003.7586461.bard.

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Objectives: (1) Evaluate Immunocompetence-OTL-containing Chromosomal Regions (ICRs), marked by microsatellites or candidate genes, for magnitude of direct effect and for contribution to relationships among multiple immunocompetence, disease-resistance, and growth traits, in order to estimate epistatic and pleiotropic effects and to predict the potential breeding applications of such markers. (2) Evaluate the interaction of the ICRs with genetic backgrounds from multiple sources and of multiple levels of genetic variation, in order to predict the general applicability of molecular genetic markers across widely varied populations. Background: Diseases cause substantial economic losses to animal producers. Emerging pathogens, vaccine failures and intense management systems increase the impact of diseases on animal production. Moreover, zoonotic pathogens are a threat to human food safety when microbiological contamination of animal products occurs. Consumers are increasingly concerned about drug residues and antibiotic- resistant pathogens derived from animal products. The project used contemporary scientific technologies to investigate the genetics of chicken resistance to infectious disease. Genetic enhancement of the innate resistance of chicken populations provides a sustainable and ecologically sound approach to reduce microbial loads in agricultural populations. In turn, animals will be produced more efficiently with less need for drug treatment and will pose less of a potential food-safety hazard. Major achievements, conclusions and implications:. The PI and co-PIs had developed a refined research plan, aiming at the original but more focused objectives, that could be well-accomplished with the reduced awarded support. The successful conduct of that research over the past four years has yielded substantial new information about the genes and genetic markers that are associated with response to two important poultry pathogens, Salmonella enteritidis (SE) and Escherichia coli (EC), about variation of immunocompetence genes in poultry, about relationships of traits of immune response and production, and about interaction of genes with environment and with other genes and genetic background. The current BARD work has generated a base of knowledge and expertise regarding the genetic variation underlying the traits of immunocompetence and disease resistance. In addition, unique genetic resource populations of chickens have been established in the course of the current project, and they are essential for continued projects. The US laboratory has made considerable progress in studies of the genetics of resistance to SE. Microsatellite-marked chromosomal regions and several specific genes were linked to SE vaccine response or bacterial burden and the important phenomenon of gene interaction was identified in this system. In total, these studies demonstrate the role of genetics in SE response, the utility of the existing resource population, and the expertise of the research group in conducting such experiments. The Israeli laboratories had showed that the lines developed by selection for high or low level of antibody (Ab) response to EC differ similarly in Ab response to several other viral and bacterial pathogens, indicating the existence of a genetic control of general capacity of Ab response in young broilers. It was also found that the 10w-Ab line has developed, possibly via compensatory "natural" selection, higher cellular immune response. At the DNA levels, markers supposedly linked to immune response were identified, as well as SNP in the MHC, a candidate gene responsible for genetic differences in immunocompetence of chickens.
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