Log in

Relevant bibliographies by topics / Lymphatic system / Dissertations / Theses

To see the other types of publications on this topic, follow the link: Lymphatic system.

Dissertations / Theses on the topic 'Lymphatic system'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 dissertations / theses for your research on the topic 'Lymphatic system.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.

1

Abu-Hijleh, Marwan. "Studies on the lymphatic system." Thesis, University of Glasgow, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.305962.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Harty, Helen Rosemary. "Nervous control of the sheep lymphatic system." Thesis, Queen's University Belfast, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.335493.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Christy, Nicola Margaret. "Targeting of colloids to the lymphatic system." Thesis, University of Nottingham, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.334516.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Hawley, Ann Elizabeth. "The uptake of nanospheres by the lymphatic system." Thesis, University of Nottingham, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.307765.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Uddin, Mohammad Nasir. "Lymphatic and glymphatic systems in the eye: relevance to ocular fluid drainage and glaucoma." Thesis, The University of Sydney, 2021. https://hdl.handle.net/2123/27235.

Full text

Abstract:

This thesis investigates retinal glymphatic and meningeal lymphatic systems in mammalian eyes, with an emphasis on structural characterization and glaucomatous changes in human eye. Chapter 2 investigates a glymphatic pathway in human and rat retina. Retinas from post-mortem human eyes were examined using immunohistochemistry and in ultrastructural studies. Dextrans were injected into the vitreous chamber of adult rat eyes. Retinal astrocytes and Müller cells were seen to envelop the entire retinal vasculature and express aquaporin-4 (AQP4) on their perivascular end feet. Perivascular spaces w

APA, Harvard, Vancouver, ISO, and other styles

6

Castor, Joshua D. "The Role of GPNMB on Lymphangiogenesis." NEOMED College of Graduate Studies / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ne2gs1625058092906364.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Boulton, Melfort R. "Quantitation of lymphatic drainage of the central nervous system in sheep." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq41406.pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Akin, Ryan E. "Minimally invasive assessment of lymphatic pumping pressure using near infrared imaging." Thesis, Georgia Institute of Technology, 2013. http://hdl.handle.net/1853/47536.

Full text

Abstract:

Although the major functions of the lymphatic system are fairly well defined, its vasculature has yet to be well characterized in comparison to its blood vasculature counterpart. Recent advances in optical imaging techniques have allowed for more detailed and quantitative evaluations of lymph flow dynamics and mechanism. A rat tail is often used for investigations of lymph flow because of the simple geometry, superficial nature, and disease progression models of its collecting lymphatic vessels. In this study, a pressure cuff system was fabricated and coupled with an existing functional near i

APA, Harvard, Vancouver, ISO, and other styles

9

Almasmoum, Hibah. "Biochemical analysis of the BTG1 variants associated with Non-Hodgkin's lymphoma." Thesis, University of Nottingham, 2017. http://eprints.nottingham.ac.uk/47720/.

Full text

Abstract:

Non-Hodgkin’s lymphoma (NHL) is a group of lympho-proliferative disorders characterised by genetic mutations resulting in the selection of a malignant clone. Recently, mutations in the anti-proliferative B-cell translocation 1 gene (BTG1) and B-cell translocation 2 gene (BTG2) have been identified in in NHL cases, which suggests a direct involvement of BTG1 and BTG2 in malignant transformation. BTG1 and BTG2 are members of the human BTG/TOB family. They are characterised by the conserved amino-terminal BTG domain, which mediates interactions with the human Caf1(hCaf1) catalytic subunit of the

APA, Harvard, Vancouver, ISO, and other styles

10

Ahankari, A. S. "Maharashtra Anaemia Study : an investigation of factors associated with adolescent health and pregnancy-related outcomes in women from Maharashtra State, India." Thesis, University of Nottingham, 2017. http://eprints.nottingham.ac.uk/47078/.

Full text

Abstract:

Maharashtra Anaemia study (MAS) was conducted as a part of the PhD programme of Dr Anand Ahankari through a joint collaboration of the University of Nottingham, UK and Halo Medical Foundation, India. The main goal of the study was to establish baseline epidemiological data for anaemia research in pregnant women and adolescent girls in Maharashtra state of India. Iron deficiency anaemia is the most common form of anaemia observed in India, and assessed based on haemoglobin (Hb) levels in blood. Clinically, anaemia is categorised in mild, moderate and severe form based on Hb levels. The project

APA, Harvard, Vancouver, ISO, and other styles

11

Aldosari, Sahar. "Assessment of DNA damage and DNA damage response and repair in dormancy-enriched leukemia cells." Thesis, University of Nottingham, 2017. http://eprints.nottingham.ac.uk/47257/.

Full text

Abstract:

Acute myeloid leukaemia (AML) is a heterogeneous myeloid malignancy characterized by clonal expansion of abnormal/immature hematopoietic precursor cells in the bone marrow. A side compartment in the BM niche consists of abnormal, quiescent cells, which are called dormant leukemic initiating cells (DLICs). Patients with AML tend to respond well to remission induction chemotherapy, but relapse is common because current therapies cannot completely eradicate leukemic cells. It is widely accepted that CD34+CD38− DLICs are more resistant to chemotherapy and that they contribute to drug resistance an

APA, Harvard, Vancouver, ISO, and other styles

12

Aram, Jehan Jalal. "Granulocyte-macrophage colony-stimulating factor : expression and regulation in human immune responses with relevance to multiple sclerosis." Thesis, University of Nottingham, 2018. http://eprints.nottingham.ac.uk/48853/.

Full text

Abstract:

Background: Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) is a haematopoietic growth factor and a pro-inflammatory cytokine produced by T cells and other immune cells. Recent evidence suggests that GM-CSF plays an important role in multiple sclerosis (MS) pathogenesis. Few recent studies have detected GM-CSF expression by immune cells in MS. In this thesis, the expression of GM-CSF and its receptor by different subtypes of peripheral blood mononuclear cells (PBMCs) in MS was investigated. In addition, GM-CSF regulation was studied in the above-mentioned cells in MS. Finally, GM-CSF

APA, Harvard, Vancouver, ISO, and other styles

13

Kornuta, Jeffrey Alan. "Characterization of lymphatic pump function in response to mechanical loading." Diss., Georgia Institute of Technology, 2014. http://hdl.handle.net/1853/52208.

Full text

Abstract:

The lymphatic system is crucial for normal physiologic function, performing such basic functions as maintaining tissue fluid balance, trafficking immune cells, draining interstitial proteins, as well as transporting fat from the intestine to the blood. To perform these functions properly, downstream vessels (known as collecting lymphatics) actively pump like the heart to dynamically propel lymph from the interstitial spaces of the body to the blood vasculature. However, despite the fact that lymphatics are so important, there exists very little knowledge regarding the details of this active pu

APA, Harvard, Vancouver, ISO, and other styles

14

Karpf, Ditte Maria. "Intestinal lipoprotein secretion and lymphatic transport of poorly aqueous soluble compounds /." Kbh. : The Danish University of Pharmaeutical Sciences, Department of Pharmaceutics, 2005. http://www.dfuni.dk/index.php/Previous_PhD_Defences_2005/1735/0/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

15

Dickstein, Jodi B. "The effects of sleep and tumour necrosis factor-Ã on the lymphatic system." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape8/PQDD_0021/NQ45754.pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

16

Bhattacharjee, Shaumick. "Investigations into mechanisms of macrophage clearance via the lymphatic system during acute inflammation." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:1c2b5c6d-63af-4ac7-926b-431b66705932.

Full text

Abstract:

The lymphatic system is an important vascular network with many important roles which include maintaining fluid homeostasis and acting as a conduit for immune surveillance as well as to clear leucocytes from inflammatory zones. Macrophages are one such population that require to be removed from sites of inflammation to restore physiological homeostasis; persistent accumulation of macrophages is seen as a hallmark of chronic inflammation which has severe consequences in health. This thesis is concerned with the mechanisms regulating entry of these myeloid cells into the lymphatic capillaries. I

APA, Harvard, Vancouver, ISO, and other styles

17

Bird, Lydia. "A randomised controlled trial of a rehabilitation programme to assist physical and psychosocial recovery after stem cell transplantation." Thesis, University of Nottingham, 2008. http://eprints.nottingham.ac.uk/13857/.

Full text

Abstract:

Background Stem cell transplantation is routinely used in the treatment of haematological malignancy. However, it is an intensive treatment frequently associated with a considerable deterioration in patients' wellbeing and prolonged recovery. Research into the amelioration of the negative biopsychosocial factors associated with stem cell transplantation is essential, facilitating nurses and other health professionals to provide the best possible care to individuals who have been treated with a stem cell transplant. Study Design 58 patients who had been treated with a stem cell transplant were

APA, Harvard, Vancouver, ISO, and other styles

18

Bhayat, Fatima. "The epidemiology of leukaemia in the UK." Thesis, University of Nottingham, 2010. http://eprints.nottingham.ac.uk/11726/.

Full text

Abstract:

INTRODUCTION Approximately 9% of all new malignant diagnoses in the UK are due to haematological malignancies. The acute and chronic leukaemias constitute 2.5 % of all cancers and leukaemia is the 12th most common cancer registered in the UK. Approximately 7 000 people are diagnosed with the disease and more than 4 300 people die from leukaemia in the UK each year. As such, they have an important impact on the health of the public and represent a significant cost to the health care budget. AIMS AND OBJECTIVES The research presented in this thesis firstly aimed to quantify the incidence of and

APA, Harvard, Vancouver, ISO, and other styles

19

Al-Asadi, Mazin Gh. "Investigation of dormancy in acute myeloid leukaemia cells and the induction of dormancy in their response to genotoxic stress." Thesis, University of Nottingham, 2017. http://eprints.nottingham.ac.uk/43320/.

Full text

Abstract:

Cancer cells can exist in a reversible state of dormancy (G0 phase of the cell cycle). Relapse of acute myeloid leukaemia (AML) is likely due to dormant cells escape frontline treatment. Dormant AML cells have been identified in the bone marrow (BM) endosteal region which is characterised by an excess of TGFβ1 and a shortage of nutrients. As the first step in this project, we developed an in vitro model of AML cell dormancy by exploiting these features. Following a preliminary investigation of four AML cell lines, the CD34+CD38- line TF1-a was selected for in-depth investigation. TF1-a showed

APA, Harvard, Vancouver, ISO, and other styles

20

Grundy, Martin. "Activity of the aurora kinase B inhibitor AZD1152 in acute myeloid leukaemia." Thesis, University of Nottingham, 2012. http://eprints.nottingham.ac.uk/12758/.

Full text

Abstract:

Aurora kinases play an essential role in orchestrating chromosome alignment, segregation and cytokinesis during mitotic progression, with both aurora-A and B frequently over-expressed in a variety of human malignancies including those of leukaemic origin. Acute myeloid leukaemia (AML) is a heterogeneous clonal disorder of haematopoietic progenitor cells whose prognosis is particularly poor and where standard induction therapy has changed little over the past thirty years. This thesis evaluated the effects of AZD1152-hQPA (barasertib-hQPA), a highly selective inhibitor of aurora-B kinase, in AM

APA, Harvard, Vancouver, ISO, and other styles

21

Baliousis, Michail. "Psychological intervention to alleviate distress in haematopoietic stem cell transplantation : a phase II study." Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/32779/.

Full text

Abstract:

Background. Haematopoietic stem cell transplantation (HSCT) is an intensive procedure associated with psychological distress particularly during the first weeks (acute phase). Based on the self-regulatory model of adjustment to illness, a preparatory group intervention was developed aiming at alleviating distress by reducing negative perceptions of HSCT and fostering helpful coping. Aims. The present study aimed to evaluate the feasibility of delivering the intervention and of conducting a trial to assess its efficacy. It also aimed to explore the applicability of the self-regulatory model in

APA, Harvard, Vancouver, ISO, and other styles

22

Yu, N. "Identifying and targeting dormant cells in acute myeloid leukaemia." Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/33679/.

Full text

Abstract:

Relapse in AML is thought to arise from dormant leukaemic cells that are characterised by low RNA synthesis activity, protected by the bone marrow (BM) niche, and may evade the effects of chemotherapeutic drugs. Our aim was to investigate agents which might be able to overcome chemoprotection by targeting the intrinsic apoptosis pathway. We developed in vitro assays to identify and characterise the dormant AML cells using combinations of markers, including the cell-division marker PKH26, leukaemia-associated phenotypes (LAPs), and dormancy markers. In a dormancy model based on 12-day AML/strom

APA, Harvard, Vancouver, ISO, and other styles

23

Arokiasamy, Samantha. "An investigation into the regulatory mechanisms of neutrophil migration into lymphatic vessels in vivo." Thesis, Queen Mary, University of London, 2017. http://qmro.qmul.ac.uk/xmlui/handle/123456789/25804.

Full text

Abstract:

Neutrophils are recognised to play a pivotal role at the interface between the innate and adaptive immune responses following their rapid recruitment to inflamed tissues and lymphoid organs. Whilst neutrophil trafficking through blood vessels has been extensively studied, the molecular mechanisms regulating their migration into the lymphatic system are still poorly understood. This thesis therefore aimed to investigate the mechanisms involved in neutrophil migration across the lymphatic endothelium during TNF- or Complete Freund's Adjuvant + antigen (CFA+Ag)-induced inflammation of cremaster m

APA, Harvard, Vancouver, ISO, and other styles

24

Afolabi, Bosede. "Plasma volume in normal and sickle cell pregnancy." Thesis, University of Nottingham, 2011. http://eprints.nottingham.ac.uk/12073/.

Full text

Abstract:

Plasma volume (PV) rises by up to 50% in normal pregnancy, a phenomenon associated with a favourable pregnancy outcome. A previous study of pregnant women with sickle cell (haemoglobin SS) disorder found that PV paradoxically contracts in late pregnancy. A cross-sectional study was performed to determine PV (Evans blue method) and volume regulatory hormones and electrolytes in pregnant women with haemoglobin (Hb) SS and in non-pregnant and Hb AA controls. PV rose in pregnant HbAA and was significantly correlated with plasma angiotensinogen. Non-pregnant Hb SS women had supranormal PV measureme

APA, Harvard, Vancouver, ISO, and other styles

25

Meader, Lucy. "Modulation of the murine lymphatic system to decipher its role in the allo-immune response." Thesis, King's College London (University of London), 2018. https://kclpure.kcl.ac.uk/portal/en/theses/modulation-of-the-murine-lymphatic-system-to-decipher-its-role-in-the-alloimmune-response(1e84b16e-a3f1-4dfb-83c7-4f87e4acecab).html.

Full text

Abstract:

The adaptive immune response to an allograft is initiated when donor-derived foreign antigens are recognised by the host immune system. This process relies on efficient trafficking of immune cells out of the graft to secondary lymphoid organs which provide a suitable niche for interactions between antigen presenting cells and allo-reactive T cells. The role of the lymphatic system in the allo-response is poorly understood, and there is evidence that lymphatics can have either a negative or a positive impact on graft survival, depending on a variety of complex factors. The contribution of lymph

APA, Harvard, Vancouver, ISO, and other styles

26

Chabanon, Johan. "Development of Tools for Stable Transfection in the Human Filarial Parasite Brugia malayi via the piggyBac transposon system." Scholar Commons, 2017. http://scholarcommons.usf.edu/etd/6689.

Full text

Abstract:

Brugia malayi is one of three species of nematode known to cause lymphatic filariasis (LF) in humans. LF infects over 120 million people, causing debilitating disease. Various global programs have been launched in the past 20 years to eliminate LF. These programs have greatly scaled up the resources and efforts allocated to halting the transmission and reducing disease burden. Only a few drugs are used to treat LF, and resistance is thus a devastating possibility. Research aimed at identifying new drug targets could therefore prove essential in elimination of LF. Genetic manipulation of B. mal

APA, Harvard, Vancouver, ISO, and other styles

27

Oliveira, Mariana Maia Freire de 1978. "Comparação dos exercícios ativos e da drenagem linfática manual nas complicações físicas e compensações linfáticas no pós-operatório de câncer de mama = Comparison of active exercise and manual lymphatic drainage on lymphatic compensations and physical complications following breast cancer surgery." [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/311108.

Full text

Abstract:

Orientador: Maria Salete Costa Gurgel<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-21T14:40:52Z (GMT). No. of bitstreams: 1 Oliveira_MarianaMaiaFreirede_D.pdf: 2898364 bytes, checksum: ef1b9a5f4cfe0e85d9868d03f8604c22 (MD5) Previous issue date: 2012<br>Resumo: Introdução: Os avanços no diagnóstico precoce e tratamento do câncer de mama resultam em longa sobrevida, acompanhada, muitas vezes, de significativa morbidade. O linfedema de membro superior (MS) ipsilateral à cirurgia apresenta incidência entre 24% e 49%

APA, Harvard, Vancouver, ISO, and other styles

28

Rezende, Laura Ferreira de. "Avaliação das compensações linfaticas no pos-operatorio de mastectomia radical atraves da linfocintilografia." [s.n.], 2008. http://repositorio.unicamp.br/jspui/handle/REPOSIP/311113.

Full text

Abstract:

Orientador: Maria Salete Costa Gurgel<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas<br>Made available in DSpace on 2018-08-11T11:22:09Z (GMT). No. of bitstreams: 1 Rezende_LauraFerreirade_D.pdf: 9192920 bytes, checksum: b761ed1e8c55e161d7c896509a841411 (MD5) Previous issue date: 2008<br>Resumo: O objetivo deste estudo foi descrever o padrão linfocintilográfico e avaliar as compensações linfáticas do membro superior no pós-operatório de câncer de mama com dissecção axilar. Sujeitos e métodos: Foram inicialmente analisadas 37 pacientes que realizaram a

APA, Harvard, Vancouver, ISO, and other styles

29

Fatima, Zainab, Haroon Rahman, Sonia Kumari Oad, Elnora Spradling, and Devapiran Jaishankar. "Lymphoma at First Sight: A Rare Case of Mantle Cell Lymphoma Presenting as Isolated Periorbital Swelling." Digital Commons @ East Tennessee State University, 2020. https://dc.etsu.edu/asrf/2020/presentations/26.

Full text

Abstract:

Mantle cell lymphoma (MCL) represents a heterogenous subtype of non-Hodgkin lymphoma (NHL), which can present in three distinct clinicopathologic variants: indolent type MCL, classic type MCL and blastoid type MCL. Despite the different variations, MCL, in general, is almost always associated with advanced-stage disease at diagnosis, with a strong predilection for significant extranodal involvement, usually to the bone marrow, CNS, peripheral blood and the gastrointestinal tract. However, the literature review reveals ocular involvement is a more rarely described extranodal site of involvement

APA, Harvard, Vancouver, ISO, and other styles

30

Villefranc, Jacques A. "Two Distinct Modes of Signaling by Vascular Endothelial Growth Factor C Guide Blood and Lymphatic Vessel Patterning in Zebrafish: A Dissertation." eScholarship@UMMS, 2011. https://escholarship.umassmed.edu/gsbs_diss/557.

Full text

Abstract:

Vascular Endothelial Growth Factor Receptor-3 (VEGFR3/Flt4) and its ligand Vegfc are necessary for development of both blood and lymphatic vasculature in vertebrates. In zebrafish, Vegfc/Flt4 signaling is essential for formation of arteries, veins, and lymphatic vessels. Interestingly, Flt4 appears to utilize distinct signaling pathways during the development of each of these vessels. To identify components of this pathway, we performed a transgenic haploid genetic screen in zebrafish that express EGFP under the control of a blood vessel specific promoter. As a result, we indentified a mutant

APA, Harvard, Vancouver, ISO, and other styles

31

Cavriani, Gabriela. "Avaliação do envolvimento do sistema linfático na inflamação pulmonar decorrente de trauma esplâncnico." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/42/42136/tde-29012008-103145/.

Full text

Abstract:

Neste estudo investigamos os mecanismos reguladores associados à indução da inflamação pulmonar decorrente da /IR intestinal. A hipótese é que mediadores inflamatórios gerados no intestino, drenados pelo sistema linfático medeiam as repercussões pulmonares observadas na SDRA. Grupos de ratos foram submetidos à isquemia intestinal por meio da oclusão da artéria mesentérica superior (45 min) seguida da reperfusão intestinal por 2h. Grupos de ratos foram submetidos à obstrução do fluxo linfático (canulação do dueto torácico linfático, ou sua secção) previamente à indução da I/R intestinal. Os dad

APA, Harvard, Vancouver, ISO, and other styles

32

Лукашук, Ю. М. "Особливості структури лімфатичних вузлів різних етапів лімфовідтоку від щитовидної залози". Thesis, Сумський державний університет, 2017. http://essuir.sumdu.edu.ua/handle/123456789/54488.

Full text

Abstract:

Многочисленность лимфатических узлов шеи, частая их поражаемость и относительная доступность делают эту группу узлов очень важным в практическом отношении объектом исследования. С другой стороны, изучение внутриорганной структуры лимфоузлов шеи в связи с их функцией проливает свет на многие морфо-функциональные аспекты современной анатомии.

APA, Harvard, Vancouver, ISO, and other styles

33

Barroso, Camila Ercolini. "Estudo quantitativo da vascularização do timo em gatos." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/10/10132/tde-13022008-115522/.

Full text

Abstract:

O timo é um órgão de grande importância imunológica durante a vida fetal e no período neonatal, para que o indivíduo se torne imunocompetente. É considerado, anatomicamente, o maior órgão com alta atividade linfopoiética no indivíduo jovem. O timo dos gatos apresenta duas porções, torácica e cervical, onde cada uma delas apresenta um lobo direito e esquerdo em sua maioria. A maior contribuição vascular origina-se da artéria torácica interna esquerda e do tronco braquiocefálico. Possui coloração rósea-pálido, localizado em região de mediastino cranial, entre os pulmões e na base do coração a po

APA, Harvard, Vancouver, ISO, and other styles

34

Shidonia, Fagarasan. "Alymphoplasia (aly)-type nuclear factor κB-inducing kinase (NIK) causes defects in secondary lymphoid tissue chemokine receptor signaling and homing of peritoneal cells to the gut-associated lymphatic tissue system". Kyoto University, 2000. http://hdl.handle.net/2433/151446.

Full text

APA, Harvard, Vancouver, ISO, and other styles

35

Castaneda-Avila, Maira A. "The Role of a Monoclonal Gammopathy of Undetermined Significance Diagnosis in Healthcare Utilization." eScholarship@UMMS, 2021. https://escholarship.umassmed.edu/gsbs_diss/1135.

Full text

Abstract:

Background Monoclonal Gammopathy of Undetermined Significance (MGUS) is an understudied precursor of multiple myeloma (MM), the second most prevalent hematologic malignancy in the United States. This dissertation was designed to: (1) Describe the trajectories of serum biomarkers over time in patients with an MGUS diagnosis, (2) Determine if an MGUS diagnosis is associated with changes in healthcare service utilization, and (3) explore the patient- and provider-level drivers of healthcare utilization in patients with MGUS. Methods Data sources include health claims and electronic health records

APA, Harvard, Vancouver, ISO, and other styles

36

Cromwell, Mary A. "The Role of T Lymphocytes in the hu-PBMC-SCID Mouse Model of Epstein-Barr Virus-Associated Lymphoproliferative Disease." eScholarship@UMMS, 1995. https://escholarship.umassmed.edu/gsbs_diss/158.

Full text

Abstract:

Epstein-Barr virus (EBV) is associated with a spectrum of benign and malignant lymphoproliferative disorders, including acute infectious mononucleosis (IM), Burkitt's lymphoma (BL) and immunosuppression-associated B cell lymphoproliferative disease (LPD). Immunosurveillance mediated by virus-specific cytotoxic T lymphocytes is believed to protect immunocompetent hosts from EBV-associated lymphoma and LPD. Due to the lack of an adequate animal model, however, the precise immunologic mechanisms which provide this protection have not been directly demonstrated in vivo. Human peripheral blood mono

APA, Harvard, Vancouver, ISO, and other styles

37

Agreste, Fernanda Rodrigues. "Estudo quantitativo da vascularização do timo em cães." Universidade de São Paulo, 2005. http://www.teses.usp.br/teses/disponiveis/10/10132/tde-28062006-174523/.

Full text

Abstract:

Durante a vida fetal e no período neonatal, o timo é órgão de grande importância imunológica e, anatomicamente é o maior órgão linfático e com alta atividade linfopoiética, constando como precursor da linfopoiese. No que diz respeito à irrigação do timo em cães, a literatura é escassa, visto que os autores quando se reportam ao assunto fazem-no na sua maioria de maneira genérica. Com isso, aspectos morfológicos como número de vasos, tamanho do órgão foram estudados considerando as variáveis sexo e faixas etárias. Para este estudo, foram utilizados 24 fetos de cães domésticos, sem raça definida

APA, Harvard, Vancouver, ISO, and other styles

38

Cullion, Kathleen J. "Mechanisms of NOTCH1 Mediated Leukemogenesis: A Dissertation." eScholarship@UMMS, 2009. https://escholarship.umassmed.edu/gsbs_diss/537.

Full text

Abstract:

Gain of function NOTCH1 mutations are common in both patients with T-ALL and in mouse models of the disease. Inhibiting the Notch pathway in T-ALL cell lines results in growth arrest and/or apoptosis in vitro, suggesting a requirement for Notch signaling in T-ALL. Therefore, we sought to examine the role of Notch1 signaling in both premalignancy and in the maintenance of leukemic growth. Using a murine model of T-ALL, in which expression of the Tal1 and Lmo2 oncogenes arrests thymocyte development, our preleukemic studies reveal that Notch1 mutations are early events that contribute to the clo

APA, Harvard, Vancouver, ISO, and other styles

39

AKANJI, AKINKUNMI G. "Estudo de conjugação do anticorpo anti-CD20 para marcação com radionuclídeos metálicos ou lantanídeos." reponame:Repositório Institucional do IPEN, 2013. http://repositorio.ipen.br:8080/xmlui/handle/123456789/28021.

Full text

Abstract:

Submitted by Pedro Silva Filho (pfsilva@ipen.br) on 2017-11-17T17:17:04Z No. of bitstreams: 0<br>Made available in DSpace on 2017-11-17T17:17:04Z (GMT). No. of bitstreams: 0<br>Linfomas são cânceres que se iniciam a partir da transformação maligna de um linfócito no sistema linfático. Os linfomas são divididos em duas categorias principais: os linfomas de Hodgkin e todos os outros linfomas, denominados linfomas não-Hodgkin (LNH). Os pacientes com LNH são comumente tratados com radioterapia apenas ou combinada com quimioterapia utilizando-se de anticorpo monoclonal anti-CD20, principalmente o

APA, Harvard, Vancouver, ISO, and other styles

40

Silva, Priscila. "Avaliação ultrassonográfica dos linfonodos loco-regionais em cadelas com neoplasmas mamários." Universidade Estadual Paulista (UNESP), 2018. http://hdl.handle.net/11449/153408.

Full text

Abstract:

Submitted by PRISCILA SILVA null (priscilasvet@gmail.com) on 2018-04-05T14:21:37Z No. of bitstreams: 1 Dissertação Priscila Silva.pdf: 1846233 bytes, checksum: 95363950f8300b574023fbfe2f7b3eb8 (MD5)<br>Approved for entry into archive by Alexandra Maria Donadon Lusser Segali null (alexmar@fcav.unesp.br) on 2018-04-06T10:29:16Z (GMT) No. of bitstreams: 1 silva_p_me_jabo.pdf: 1846233 bytes, checksum: 95363950f8300b574023fbfe2f7b3eb8 (MD5)<br>Made available in DSpace on 2018-04-06T10:29:16Z (GMT). No. of bitstreams: 1 silva_p_me_jabo.pdf: 1846233 bytes, checksum: 95363950f8300b574023fbfe2f7b3e

APA, Harvard, Vancouver, ISO, and other styles

41

Pan, Feng. "Understanding Ten-Eleven Translocation-2 in Hematological and Nervous Systems." FIU Digital Commons, 2014. http://digitalcommons.fiu.edu/etd/1925.

Full text

Abstract:

I proposed the study of two distinct aspects of Ten-Eleven Translocation 2 (TET2) protein for understanding specific functions in different body systems. In Part I, I characterized the molecular mechanisms of Tet2 in the hematological system. As the second member of Ten-Eleven Translocation protein family, TET2 is frequently mutated in leukemic patients. Previous studies have shown that the TET2 mutations frequently occur in 20% myelodysplastic syndrome/myeloproliferative neoplasm (MDS/MPN), 10% T-cell lymphoma leukemia and 2% B-cell lymphoma leukemia. Genetic mouse models also display distinc

APA, Harvard, Vancouver, ISO, and other styles

42

Vitoretti, Luana Beatriz. "Perfil temporal da inflamação pulmonar induzida pela isquemia/reperfusão intestinal em ratos. Estudo do papel do sistema linfático." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/42/42136/tde-06082010-133158/.

Full text

Abstract:

A isquemia/reperfusão intestinal (I/R-i) se associa ao desenvolvimento de inflamação pulmonar aguda, que pode ser modulada por mediadores inflamatórios presentes na linfa. Avaliamos os efeitos da I/R-i sob a inflamação pulmonar e a participação do sistema linfático. Wistar machos foram submetidos a 45 min de isquemia intestinal e 24, 72 ou 120 h de reperfusão. Outro grupo teve o ducto linfático bloqueado antes da isquemia. Os resultados revelaram maior inflamação pulmonar nos animais reperfundidos por 120 h em relação aos outros períodos de reperfusão estudados. Os animais apresentaram aumento

APA, Harvard, Vancouver, ISO, and other styles

43

Ferrão, Juliana Shimara Pires. "Tratamento com VEGFC para revascularização linfática em membros pélvicos de camundongos." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/10/10132/tde-08012014-112630/.

Full text

Abstract:

A revascularização linfática é um desafio e o estabelecimento de novas estratégias terapêuticas podem melhorar a qualidade de vida de pessoas que sofrem de distúrbios linfáticos. O objetivo deste estudo foi verificar a capacidade de tratamento com VEGFC exógeno na melhoria da vascularização linfática de uma maneira dependente do tempo em membros pélvicos (MP) de camundongos após a remoção do linfonodo inguinal. O linfonodo inguinal esquerdo foi removido cirurgicamente para mimetizar patologias com diminuição da vascularização linfática. Densidade vascular linfática (Vv) e de comprimento (Lv) f

APA, Harvard, Vancouver, ISO, and other styles

44

Nie, Siwei. "Role of TNF in Heterologous Immunity between Lymphocytic Choriomeningitis Virus and Vaccinia Virus: A Dissertation." eScholarship@UMMS, 2008. https://escholarship.umassmed.edu/gsbs_diss/394.

Full text

Abstract:

Prior immunity to a related or unrelated pathogen greatly influences the host’s immune response to a subsequent infection and can cause a dramatic difference in disease course, a phenomenon known as heterologous immunity. Heterologous immunity can influence protective immunity, immunopathology and/or immune deviation of cytokine-producing T cell subsets. Examples of heterologous immunity have been well documented in mouse models, as well as during human infections. For example, prior immunity to lymphocytic choriomeningitis virus (LCMV) provides partial protection against vaccinia virus (VV),

APA, Harvard, Vancouver, ISO, and other styles

45

Precopio, Melissa Lynn. "EBV-Specific CD4+ T Cell Responses in Acute Infectious Mononucleosis: a Dissertation." eScholarship@UMMS, 2004. https://escholarship.umassmed.edu/gsbs_diss/113.

Full text

Abstract:

Epstein-Barr virus (EBV) is a ubiquitous herpesvirus that establishes a life-long latent infection of B cells. It is usually asymptomatic in healthy individuals; however, individuals with compromised immunity often develop EBV-induced lymphoma. EBV also encodes potential oncogenes that can contribute to tumorigenesis. Therefore, vaccine and immunotherapeutic strategies targeting EBV are desirable. Recent studies have shown that infusion of EBV-specific CD8+T cells can elicit remission of lymphomas arising after administration of immunosuppressive drugs during transplantation, suggesting an imp

APA, Harvard, Vancouver, ISO, and other styles

46

Shockett, Penny E. "Regulation of IgA Class Switch Recombination in the I.29μ B Cell Lymphoma by Cytokines and Inhibitors of Poly(ADP-ribose) Polymerase: A Thesis". eScholarship@UMMS, 1993. https://escholarship.umassmed.edu/gsbs_diss/133.

Full text

Abstract:

Heavy chain isotype switch recombination is preceded by the appearance of RNA initiating 5' of the specific switch region which will undergo recombination. In an effort to understand the potential function of germline transcripts in switch recombination and the degree to which the regulation of germline transcripts correlates with the regulation of switching, we studied this process in the murine B-lymphoma cell line I.29μ, which in the presence of bacterial lipopolysaccharide (LPS) switches primarily to IgA and less frequently to IgE. Levels of α-germline transcripts initiating upstream of α

APA, Harvard, Vancouver, ISO, and other styles

47

Balli-Antunes, Mariette Filomena. "The mortality from malignancies of haemopoietic and lymphatic systems among railway engine drivers /." Bern, 1990. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

Full text

APA, Harvard, Vancouver, ISO, and other styles

48

Jurisic, Giorgia. "A systems genetics approach reveals novel modifier genes of lymphatic endothelium function in inflammation /." [S.l.] : [s.n.], 2009. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=18541.

Full text

APA, Harvard, Vancouver, ISO, and other styles

49

Segrave, Alicia Maree. "An investigation of the pharmacokinetics and lymphatic transport of recombinant human leukaemia inhibitory factor." Monash University, Dept. of Pharmaceutics, 2004. http://arrow.monash.edu.au/hdl/1959.1/9389.

Full text

APA, Harvard, Vancouver, ISO, and other styles

50

Oussoren, Christien. "Subcutaneous administration of liposomes for lymphatic targeting : a biopharmaceutical study = Subcutane toediening van liposomen voor targeting naar het lymfatische systeem /." [S.l. : s.n.], 1996. http://www.gbv.de/dms/bs/toc/242984827.pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!