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Relevant bibliographies by topics / Lymphoblastic leukemia in children Lymphoblastic leukemia in children Cognition in children

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Academic literature on the topic 'Lymphoblastic leukemia in children Lymphoblastic leukemia in children Cognition in children'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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Journal articles on the topic "Lymphoblastic leukemia in children Lymphoblastic leukemia in children Cognition in children"

1

Abraham, Anna, and L. Appaji. "Cognitive assessment of children with acute lymphoblastic leukemia: Preliminary findings." Indian Journal of Medical and Paediatric Oncology 30, no. 1 (2009): 14. http://dx.doi.org/10.4103/0971-5851.56330.

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Hooke, Mary C., Daniel Hatch, Marilyn J. Hockenberry, Susan Whitman, Ida Moore, David Montgomery, Kari Marano, et al. "The Longitudinal Parallel Process Analysis of Biomarkers of Oxidative Stress, Symptom Clusters, and Cognitive Function in Children With Leukemia." Journal of Pediatric Oncology Nursing 37, no. 4 (March 6, 2020): 244–54. http://dx.doi.org/10.1177/1043454220909785.

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Background: During treatment for acute lymphoblastic leukemia (ALL), children report co-occurring symptoms of fatigue, sleep disturbance, pain, nausea, and depression as a symptom cluster. Central nervous system–directed ALL therapies also put children at risk for cognitive impairments. Cancer therapies can cause an increase in oxidative stress, which may contribute to treatment-related symptoms. This study examined the longitudinal relationships between biomarkers of oxidative stress in the cerebrospinal fluid, the Childhood Cancer Symptom Cluster–Leukemia (CCSC-L), and cognition, in children over the first year of ALL treatment. Methods: Glutathione (GSH) biomarkers of oxidative stress were measured in cerebrospinal fluid collected during treatment lumbar punctures. GSH biomarkers, symptoms, and cognitive function of 132 children aged 3 to 18 years were evaluated at four time points during the first year of leukemia treatment. Participants, 7 years and older, completed self-report measures, and parents reported for younger children. Cognitive function measurements for all participants were completed by parents. A longitudinal parallel-process model was used to explore the influence of the initial measurement and the subsequent change over four time points of the GSH biomarkers on the CCSC-L and cognition. Results: GSH biomarkers increased over the four time points indicating decreasing oxidative stress. When GSH biomarkers were higher (less oxidative stress) at the initial measurement, the CCSC-L severity was lower, cognition was better, and cognition improved over the four measurements. Screening children for high levels of oxidative stress would be a foundation for future intervention studies to address symptom distress and cognitive impairments.

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Waber, Deborah P., Lewis B. Silverman, Lori Catania, William Mautz, Montse Rue, Richard D. Gelber, Donna E. Levy, et al. "Outcomes of a Randomized Trial of Hyperfractionated Cranial Radiation Therapy for Treatment of High-Risk Acute Lymphoblastic Leukemia: Therapeutic Efficacy and Neurotoxicity." Journal of Clinical Oncology 22, no. 13 (July 1, 2004): 2701–7. http://dx.doi.org/10.1200/jco.2004.10.173.

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Purpose We evaluated 8-year survival and late neuropsychologic toxicity in children with acute lymphoblastic leukemia treated in a randomized clinical trial to test whether hyperfractionated (twice daily) cranial radiation therapy (CRT) can reduce incidence and severity of late toxicities associated with 18 Gy of CRT. Patients and Methods Between 1987 and 1995, 369 children treated on two consecutive Dana-Farber Cancer Institute Consortium protocols for high-risk acute lymphoblastic leukemia were randomly assigned to conventionally fractionated CRT (CFX) or hyperfractionated CRT (HFX) to a total dose of 18 Gy. Neuropsychologic testing was completed for 125 of 287 children in continuous complete remission. Event-free and overall survival, as well as neuropsychologic function, were compared for the two arms of the protocol. Results Eight-year event-free survival (± SE) was 80% ± 3% for children randomly assigned to CFX and 72% ± 3% for HFX (P = .06). Overall survival was 85% ± 3% for CFX and 78% ± 3% for HFX (P = .06). CNS relapses occurred in 2.8% of patients receiving CFX and 2.7% receiving HFX (P = .99). Cognitive function for both groups was solidly in the average range, with no group differences in intelligence, academic achievement, visuospatial reasoning, or verbal learning. Children on the HFX arm exhibited a modest advantage for visual memory (P < .05). Conclusion HFX provides no benefit in terms of cognitive late effects and may compromise antileukemic efficacy. HFX should not be substituted for conventionally dosed CRT in children who require radiation therapy for treatment of acute lymphoblastic leukemia.

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Wright, Marilyn J., Vicky Galea, and Ronald D. Barr. "Proficiency of Balance in Children and Youth Who Have Had Acute Lymphoblastic Leukemia." Physical Therapy 85, no. 8 (August 1, 2005): 782–90. http://dx.doi.org/10.1093/ptj/85.8.782.

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Abstract Background and Purpose. As the survival rate for acute lymphoblastic leukemia (ALL) in childhood increases, long-term sequelae are a growing concern. This cross-sectional, descriptive study compared the balance skills of children and youth who have had ALL with those of comparable subjects and explored associations with demographics, therapy, physical activity, and health-related quality of life (HRQL). Subjects. Ninety-nine subjects treated previously for ALL and 89 comparison subjects were examined. Methods. Measures included the Bruininks-Oseretsky Test of Motor Proficiency (BOTMP) balance subtest, the Children's Self-perceptions of Adequacy in and Predilection for Physical Activity Scale (CSAPPA), and the Health Utilities Index (HUI), a measure of HRQL. Results. The children and youth who had ALL had poorer balance than the comparison subjects (BOTMP=10.55 and 16.30, respectively) and lower CSAPPA scores (57.72 and 63.72, respectively) and HUI scores (0.86 and 0.97, respectively). Regression analyses identified exposure to cranial irradiation, being overweight, lower CSAPPA scores for adequacy, and lower HUI single-attribute scores for cognition as predictors of lower balance scores in subjects who had ALL. Discussion and Conclusion. Balance abilities in subjects treated for ALL were compromised, and several factors were associated with this deficit.

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Warris, Lidewij T., Marry M. van den Heuvel-Eibrink, Ingrid M. Ariës, Rob Pieters, Erica L. T. van den Akker, and Monique L. Den Boer. "Hydrocortisone does Not Influence in Vitro Glucocorticoid Sensitivity of Acute Lymphoblastic Leukemia Blasts." Blood 124, no. 21 (December 6, 2014): 5228. http://dx.doi.org/10.1182/blood.v124.21.5228.5228.

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Abstract Introduction: Dexamethasone-induced neuropsychological side effects on mood, behavior and cognition seriously affect quality of life in children with acute lymphoblastic leukemia (ALL) during a long treatment period. Based on recent studies in animals, we hypothesized that these neuropsychological side effects are mediated by dexamethasone-induced cortisol depletion of the mineralocorticoid receptor (MR) in the brain. Therefore, we hypothesize that these side effects could be ameliorated by an intervention with hydrocortisone. For clinical application settings however, an absolute prerequisite is that MR activation does not interfere with the efficacy of the glucocorticoids, dexamethasone and prednisolone, on ALL cells. Materials and Methods: To investigate responsiveness of leukemic cell lines and fresh patients’ leukemic cells to dexamethasone and prednisolone in the presence of hydrocortisone, MTT-assays were performed. In addition MR and the glucocorticoid receptor (GR) expression on leukemic cells of different ALL subtypes was studied with a microarray-based gene expression profiling and validated by quantitative real-time PCR. Results: Leukemic cells expressed the MR at a very low level with a significantly higher (P≤0.001) expression in ETV6-RUNX1+ patients (median: 160.7 [AU] of fluorescence intensity, range: 38.1 - 760.6 [AU]) versus other ALL subtypes (median: 41.8 [AU] of fluorescence intensity, range: 25.1 - 276.2 [AU]). MR expression did not differ between glucocorticoid resistant and sensitive patients’ cells. Hydrocortisone addition did not affect glucocorticoid sensitivity of leukemic cell lines and patients’ leukemic cells of different leukemic subtypes also including ETV6-RUNX1+. Glucocorticoid sensitive patients’ cells became significantly more sensitive by hydrocortisone addition (prednisolone: P≤0.01, dexamethasone: P≤0.05). Conclusion: This present study shows that hydrocortisone does not interfere with efficacy of dexamethasone and prednisolone in vitro. These findings support a clinical randomized trial to study whether addition of hydrocortisone decreases the neuropsychological side effects of dexamethasone in children with ALL. Acknowledgments: The financial support of the KiKa® (Kinderen Kankervrij) foundation is highly appreciated. Disclosures No relevant conflicts of interest to declare.

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Waber, Deborah P., Sarah C. Carpentieri, Neil Klar, Lewis B. Silverman, Molly Schwenn, Craig A. Hurwitz, Phyllis J. Mullenix, Nancy J. Tarbell, and Stephen E. Sallan. "Cognitive Sequelae in Children Treated for Acute Lymphoblastic Leukemia With Dexamethasone or Prednisone." Journal of Pediatric Hematology/Oncology 22, no. 3 (May 2000): 206–13. http://dx.doi.org/10.1097/00043426-200005000-00004.

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Williams, Kelli S., Judith Ochs, J. Michael Williams, and Raymond K. Mulhern. "Parental Report of Everyday Cognitive Abilities Among Children Treated For Acute Lymphoblastic Leukemia." Journal of Pediatric Psychology 16, no. 1 (1991): 13–26. http://dx.doi.org/10.1093/jpepsy/16.1.13.

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Yildiz Kabak, Vesile, Yasin Ekinci, Songul Atasavun Uysal, Mualla Cetin, and Tulin Duger. "Motor and Basic Cognitive Functions in Children with Acute Lymphoblastic Leukemia Undergoing Induction or Consolidation Chemotherapy." Perceptual and Motor Skills 128, no. 3 (March 17, 2021): 1091–106. http://dx.doi.org/10.1177/00315125211002065.

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Children with acute leukemia (ALL) often suffer from several disease and treatment related side-effects during treatment. The aim of the present study was to determine the gross and fine motor functioning and basic cognitive performance of children (n = 25) with ALL who were undergoing induction or consolidation chemotherapy and to compare these characteristics to a normative group (n = 21) of age-matched typically developing children. We assessed the children’s motor functions with the Bruininks-Oseretsky Test of Motor Proficiency Second Edition-Short Form and the Nine-hole Peg Test, and we used the Modified Mini-Mental State Exam (MMSE) to evaluate their cognitive performance. Compared to the normative group, children with ALL had lower scores on total motor proficiency and sub-tests scores of motor functions ( p < .05), and on the Nine-hole Peg Test performance ( p < .05); but their cognitive performance on the MMSE was not significantly different. Children with ALL would likely benefit from structured exercise and rehabilitative interventions during chemotherapy to prevent and/or ameliorate ALL-related motor dysfunction. We also suggest that their cognitive functioning should be further investigated with more extensive well-validated neurocognitive tests for children (e.g., the Wechsler intelligence scales).

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Tremolada, Marta, Livia Taverna, Sabrina Bonichini, Marta Pillon, and Alessandra Biffi. "The Developmental Pathways of Preschool Children with Acute Lymphoblastic Leukemia: Communicative and Social Sequelae One Year after Treatment." Children 6, no. 8 (August 13, 2019): 92. http://dx.doi.org/10.3390/children6080092.

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Early childhood is considered to be a period of rapid development, with the acquisition of abilities predicting future positive school competences. Motor, cognitive, and social difficulties related to cancer therapies heavily impact the development of children with cancer. This study focused on two main aims: To assess the developmental pathways of preschool children with acute lymphoblastic leukemia one year post-treatment and to compare these abilities both with those of a control group of healthy peers and with Italian norms. Forty-four children and their families, recruited through the Hematology-Oncologic Clinic of the Department of Child and Woman Health (University of Padua), agreed to participate in this study. The children’s mean age was 4.52 years (SD = 0.94, range = 2.5–6 years), equally distributed by gender, all diagnosed with acute lymphoblastic leukemia. Matched healthy peers were recruited through pediatricians’ ambulatories. Each family was interviewed adopting the Vineland adaptive behavior scales. Paired sample Wilcoxon tests revealed that children were reported to have significantly more developmental difficulties than their healthy peers. When compared with Italian norms, they scored particularly low in verbal competence, social, and coping skills. No significant association was found between treatment variables and developmental abilities. These findings suggest that the creation of specialized interventions, both for parents and children, may fill the possible delays in children’s development probably due to stress, lack of adequate stimulation, or difficult adaptation.

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Balsamo, Lyn M., Kyaw J. Sint, Joseph Philip Neglia, and Nina Kadan-Lottick. "Assessment of executive function (EF) among pediatric survivors of acute lymphoblastic leukemia (ALL)." Journal of Clinical Oncology 31, no. 15_suppl (May 20, 2013): 9584. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.9584.

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9584 Background: Childhood ALL survivors are at increased risk of impaired EF. Both parent ratings and performance-based measures are used to identify vulnerable patients. We seek to assess the association between these modalities to 1) each other, and 2) need for special education and stimulants. Methods: This 22-site cross-sectional study included 256 children in remission for standard-risk precursor-B ALL previously enrolled on legacy Children's Oncology Protocols from 1993 - 2000. Patients had no history of CNS leukemia, cranial radiation, or pre-existing neurodevelopmental disorders; were ≥1 year off-therapy; and were 6-16 years at evaluation. Patients were administered performance-based measures of working memory, Digit Span (DS) and Letter-Number Sequencing (LNS) comprising the Working Memory Index (WMI) from the Wechsler Intelligence Scales for Children - Fourth Edition. Patients completed the Controlled Oral Word Association Test (COWAT). Parents completed demographic surveys and a Likert-scale assessment of executive processes, Behavior Rating Inventory of Executive Function (BRIEF). Results: There were modest correlations between BRIEF-WM scale and WMI (r=-0.20, p<0.01) and subscales, DS (r=-0.17, p<0.01) and LNS (r=-0.19, p<0.01). BRIEF-Initiate and COWAT (r=-0.22, p<0.01) were correlated. However, impaired classification based on performance-based measures was a poor predictor of parent assessment classification. The WMI and BRIEF-WM independently predicted receipt of special education (p=0.0017 and 0.0003). The BRIEF-WM and Initiate scales predicted stimulant medication use (p<0.0001 and p=0.0037); however, performance-based measures did not. Conclusions: Rater and performance-based measures provide related, but different information about EF indicating the need for both. Both measurement modalities capture educational difficulties; however, only parent ratings are associated with stimulants. This may reflect the medication's success in modifying cognition in controlled environments and the BRIEF's sensitivity to the child's ability to execute tasks in the real-world setting.

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Dissertations / Theses on the topic "Lymphoblastic leukemia in children Lymphoblastic leukemia in children Cognition in children"

1

Larery, Angela R. D. McGill Jerry C. "Hierarchical neuropsychological functioning among pediatric survivors of acute lymphoblastic leukemia." [Denton, Tex.] : University of North Texas, 2007. http://digital.library.unt.edu/permalink/meta-dc-3949.

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Larery, Angela R. D. "Hierarchical neuropsychological functioning in pediatric survivors of acute lymphoblastic leukemia." Thesis, University of North Texas, 2007. https://digital.library.unt.edu/ark:/67531/metadc3949/.

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Acute lymphocytic leukemia (ALL) is one of the most common types of pediatric cancers. Improvements in treatment within the last 20 years have resulted in reduced mortality and a greater focus upon quality of life. Several researchers have documented neuropsychological impairments in children following treatment for ALL; however, there have not been any comparative studies documenting differences in neuropsychological functioning based upon treatment modality despite the documented effects of radiation therapy and combined radiation/chemotherapy upon the developing brain. In addition, past studies have focused on unitary measures, ignoring the hierarchical relationship between basic cognitive functions and more abstract skills. This study examined the neuropsychological functioning of 81 children who were treated for ALL at a metropolitan children's hospital. All children were tested a minimum of two years after the final treatment session and were administered the NEPSY. Results do not support any interactions or main effects with the exception of the age of the child at diagnosis. Children diagnosed prior to the age of 5 showed greater impairments on tasks measuring attention, memory, and visuospatial reasoning in comparison to peers diagnosed after age 6.

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Begyn, Elizabeth Franks Susan F. "The psychosocial functioning of pediatric cancer survivors the role of neurocognitive abilities /." [Denton, Tex.] : University of North Texas, 2007. http://digital.library.unt.edu/permalink/meta-dc-4003.

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Begyn, Elizabeth. "The psychosocial functioning in pediatric cancer survivors: The role of neurocognitive abilities." Thesis, University of North Texas, 2007. https://digital.library.unt.edu/ark:/67531/metadc4003/.

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With the increase in survival for children with cancer, part of the focus of current research is aimed towards evaluating how these children are adapting psychosocially. Neurocognitive deficits have been well established. However, there are multiple facets encompassing quality of life, including general mental health, lifestyles and health behaviors, and academic and cognitive functioning. The relationship between neurocognitive and psychosocial functioning has yet to be thoroughly evaluated. The purpose of this study was to investigate the relationship between neurocognitive and psychosocial functioning in survivors of brain tumors and acute lymphoblastic leukemia. Data was collected from existing archival database comprised of patients of the at Cook Children's Medical Center in Texas. The sample consisted of 177 patients between the ages of 3 and 12 who were at least two years post-diagnosis. Measures used included the NEPSY and the Behavioral Assessment for Children. Statistical analyses included a several one-way analysis of variances, an independent samples t-test, a univariate analysis of variance, a hierarchical multiple regression, and odds ratio analyses. Results indicated survivors treated with neurosurgery alone appear to be less at risk for developing behavior problems than other treatment modalities. Also, brain tumor survivors demonstrate more problematic behaviors than survivors of acute lymphoblastic leukemia. Visuospatial functioning, diagnosis, and type of treatment were found to be predictive variables of behavior problems. Attention, and perhaps language, deficits may predispose children to more problems in their behavior. It is concluded that there are other factors affecting behavior in this population that were not accounted for in this analysis. It is recommended for future studies to research the individual clinical scales of the Behavior Assessment System for Children, obtain information from multiple informants, study this relationship longitudinally, and research additional factors that may be influencing the relationship between neurocognitive and psychosocial functioning. This provides evidence of risk factors that should be monitored as the child returns home and to school.

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卓大治 and Tai-chi Cheuk. "Childhood acute lymphoblastic leukaemia with TEL-AML1 gene fusion." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2000. http://hub.hku.hk/bib/B31969690.

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Cheuk, Tai-chi. "Childhood acute lymphoblastic leukaemia with TEL-AML1 gene fusion." Hong Kong : University of Hong Kong, 2000. http://sunzi.lib.hku.hk/hkuto/record.jsp?B22264619.

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Boag, Joanne. "The molecular characterisation of childhood acute lymphoblastic leukaemia : gene expression profiles to elucidate leukaemogenesis /." Connect to this title, 2006. http://theses.library.uwa.edu.au/adt-WU2007.0160.

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Gottardo, Nicholas G. "Oncogenes and prognosis in childhood T-cell acute lymphoblastic leukaemia." University of Western Australia. School of Paediatrics and Child Health, 2008. http://theses.library.uwa.edu.au/adt-WU2009.0039.

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[Truncated abstract] The treatment of childhood acute lymphoblastic leukaemia (ALL) is one of the great success stories of paediatric oncology, transforming a universally fatal disease into one where 75 to 90% of children are now cured. Although in the past survival for children with T-cell ALL (T-ALL) lagged behind that of children with pre-B ALL, the use of contemporary intensified treatment strategies has significantly diminished this difference, with many investigators reporting similar cure rates for both groups of patients. Despite these marked improvements, numerous challenges still face physicians treating children with T-ALL. Firstly, there have been no additional major improvements in outcome over the last decade, despite additional treatment intensification. Secondly, effective regimens remain elusive for treating children with relapsed T-ALL or patients with resistant disease. Finally, there is a need to identify patients currently potentially overtreated and thus unnecessarily subjected to acute and long term toxicities without benefit. A major challenge therefore, is the identification of novel reliable prognostic markers, in order to identify patients at high risk of relapse and conversely those least likely to relapse, to guide therapy appropriately. Children predicted with a high risk of relapse would be candidates for intensification of therapy and/or novel experimental agents. Conversely, patients predicted to be at low risk of relapse could be offered clinical trials using reduced intensity therapy, thereby minimising toxicity. '...' Crucially, the 3-gene predictor was validated in a completely independent cohort of T-ALL patients, also treated on CCG style therapy. Our 3-gene predictor appears to identify a high risk group of patients which require alternative therapeutic strategies in order to attain a cure. This study has also identified a potential novel agent for the treatment of T-ALL, which may be used as an anthracycline potentiator or anthracycline-sparing agent. We hypothesised that genes associated with a relapse signature provide promising targets for novel therapies. We tested the hypothesis that CFLAR, an inhibitor of the extrinsic apoptotic pathway and a member of the 3-gene predictor may be involved in the development of resistance to chemotherapy. To test our hypothesis we used a novel agent, 2-cyano-3, 12-dioxooleana-1,9 (11)-dien-28-oic acid (CDDO), previously shown to inhibit CFLAR protein, in two cell lines established in our laboratory from paediatric patients diagnosed with T-ALL. We found that CDDO displayed single agent activity at sub-micromolar concentrations in both cell lines tested. Importantly, minimally lethal doses of CDDO resulted in significant enhancement of doxorubicin mediated cytotoxicity in one of the cell lines assessed. The findings presented as part of this thesis have revealed the value of gene expression analysis of childhood T-ALL for identifying novel prognostic markers. This study has shown that expression profiles may provide better prognostic information than currently available clinical variables. Additionally, genes that constitute a relapse signature may provide rational targets for novel therapies, as demonstrated in this study, which assessed a potential novel agent for the treatment of T-ALL.

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Drake, Kylie Marie, and n/a. "Characterisation of the nature and timing of early events in childhood acute lymphoblastic leukaemia." University of Otago. Department of Biochemistry, 2007. http://adt.otago.ac.nz./public/adt-NZDU20070719.131918.

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Understanding the nature and timing of leukaemogenic events during the development of childhood acute lymphoblastic leukaemia (ALL) will enable intervention that could prevent ALL in the future. We hypothesised that 9p21 deletion in childhood ALL may unmask predisposing genetic events that would allow us to determine the "nature" of initiating events in childhood ALL; whereas the inclusion, or exclusion, of random �N� nucleotides in normal immunoglobulin gene rearrangements from the developing fetus and the expression of terminal deoxynucleotidyl transferase (TdT) in fetal lymphocytes may allow us to unmask the developmental window during which the first transforming leukaemic event occurs in a pre-leukaemic B cell. The most frequent genetic abnormality in childhood ALL is deletion of chromosome 9p21, with the minimal region of deletion including the CDKN2-locus, making genes at this locus candidates for a predisposing genetic event in ALL. To determine whether genomic imprinting might be involved in ALL at the 9p21 locus we investigated the imprinting status of the candidate genes CDKN2A, CDKN2B and ARF. No evidence for genomic imprinting of ARF was found in this study. Because no expressed polymorphisms could be identified for CDKN2B, and CDKN2A expression was too low in normal tissues, the imprinting status of these genes could not be evaluated. Furthermore investigations in our laboratory have been unable to find genomic imprinting at any of these genes in mice. However, we have shown variation in allelic expression of ARF, which suggests a role for ARF haploinsufficiency in the onset of childhood ALL. A key feature of early human fetal lymphoid development is the absence of random �N� nucleotides between the rearranged V[H], D[H] and J[H] gene segments. The addition of �N� nucleotides at these junctions requires the enzyme terminal deoxynucleotidyl transferase (TdT). TdT is reported to not be expressed during early fetal lymphopoiesis but has been observed by the end of the first trimester, but data are sparse. The reported absence of N nucleotides in the majority of childhood ALLs suggests an early fetal origin. By defining the window-in-time during which TdT-negative B cell development occurs, we will be able to refine the timing of the origin of the B cells that give rise to ALL. Therefore we have sequenced and analysed the V[H]-DJ[H] and D[H]-J[H] junctions from immunoglobulin rearrangements in developing B cells in normal human fetuses aged from 5.1 to 11 weeks gestation. In this study 73 fetal IgH gene rearrangements were amplified from 21 different fetal liver samples. Only eight of the seventy-three rearrangements (11%) analysed in this study had no �N� nucleotides at the N1 (D[H]-J[H]) junction. This finding contrasts with the 24-28% of fetal rearrangements with no �N� nucleotides that have been reported in the literature. Furthermore, �N� nucleotides were shown to be present in the earliest sample, 5.1 weeks gestation. TdT expression was demonstrated by immunohistochemistry at 7.3 weeks and by RT-PCR at 8.3 weeks. B cell development in the fetal liver was detected as early as 6.5 weeks using flow cytometric analysis. Then, IgH gene rearrangements from 99 cases of childhood ALL were analysed. In total, 134 clone-specific IgH gene rearrangements were examined in this study. No association was found between the number of �N� nucleotides from complete and incomplete rearrangements at either the N1 (D[H]-J[H]) or N2 (V[H]-DJ[H]) junctions. Nor was any association observed between ALLs from children [less than or equal to] 3 years of age and those >3 years of age at diagnosis. These findings indicate that ALL IgH rearrangements do not have the paucity of �N� nucleotides that has been previously reported. The findings in this thesis suggest that there is no TdT-negative timepoint during B cell development and that there is no paucity of �N� nucleotides at the N1 junction in either fetal or childhood ALL IgH gene rearrangements.

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Liem, Natalia Women's &amp Children's Health Faculty of Medicine UNSW. "The development of an in vivo model to study the biology and treatment of childhood acute lymphoblastic leukaemia (ALL)." Awarded by:University of New South Wales. Women's & Children's Health, 2007. http://handle.unsw.edu.au/1959.4/40537.

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Relapsed ALL remams one of the most common causes of death from disease in children. Broad-range drug resistance is often associated with relapse, although its underlying molecular mechanisms remained poorly understood. The aim of this thesis was to establish an in vivo model using the non-obese diabetic/severe combined immunodeficient (NOD/SCID) mouse strain, to facilitate the engraftment, expansion and characterisation of childhood ALL cells, obtained from patients at diagnosis or relapse. Mice were inoculated with leukaemia cells from patients' biopsies and engraftment was monitored by the proportion of human CD45+ cells in the blood. Successful leukaemia engraftment was achieved for 20/20 patient biopsies. Continuous passaging of ten xenografts has also been achieved. Immunophenotypic analysis showed only minor changes in cell surface markers after passage in mice. Leukaemia dissemination in murine bone marrow, liver, spleen and blood was consistent with the human disease. The in vivo responses of ten continuous xenografts to dexamethasone and vincristine, but not methotrexate, significantly correlated with patient outcome (p<0.05). Xenograft sub-lines resistant to vincristine, dexamethasone, methotrexate and cytosine arabinoside were also selected by in vivo drug treatments, although these sublines were not found to be cross resistant to structurally unrelated drugs. Resistance to vincristine, either in in vivo selected sub-lines or inherently resistant xenografts, was not associated with increased activity of drug efflux pumps such as P-gp or MRPl. Class I ?? tubulin levels remained unchanged when compared between vincristine resistant sublines and their parental xenografts. Decreased expression of stathmin and increased polymerised tubulin were observed in vincristine resistant sub-lines, suggesting a possible mechanism of counteracting the depolymerising effects of vincristine. In summary, this study has shown that primary ALL cells engraft efficiently into NOD/SCID mice, and indicates that their response to vincristine and dexamethasone mimics the clinical situation. This model appears to be highly relevant for the study of childhood ALL and will provide the foundation to delineate clinically relevant mechanisms of drug resistance.

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Books on the topic "Lymphoblastic leukemia in children Lymphoblastic leukemia in children Cognition in children"

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Childhood leukemia: A practical handbook. Heidelberg: Springer, 2011.

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Bruneau, Pierre. Quand je serai grand, je serai guéri! Montréal]: Club Québec loisirs, 2005.

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1959-, De Vailly Corinne, ed. Quand je serai grand, je serai gueri! Outremont, Quebec: Editions Publistar, 2004.

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Carl, Pochedly, ed. Childhood lymphoblastic leukemia. New York?: Praeger, 1985.

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Reaman, Gregory H., and Franklin O. Smith. Childhood Leukemia: A Practical Handbook. Springer, 2014.

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Cancer crossings: A brother, his doctors, and the quest for a cure to childhood leukemia. 2018.

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Book chapters on the topic "Lymphoblastic leukemia in children Lymphoblastic leukemia in children Cognition in children"

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Kaleita, T. A., D. G. Tubergen, J. A. Stehbens, W. E. MacLean, R. B. Noll, J. M. Cherlow, N. L. Cantor, et al. "Longitudinal Study of Cognitive, Motor, and Behavioral Functioning in Children Diagnosed with Acute Lymphoblastic Leukemia: A Report of Early Findings from the Childrens Cancer Group." In Acute Leukemias VI, 660–73. Berlin, Heidelberg: Springer Berlin Heidelberg, 1997. http://dx.doi.org/10.1007/978-3-642-60377-8_102.

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Tomizawa, Daisuke, and Nobutaka Kiyokawa. "Acute Lymphoblastic Leukemia." In Hematological Disorders in Children, 33–60. Singapore: Springer Singapore, 2017. http://dx.doi.org/10.1007/978-981-10-3886-0_2.

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Peters, Christina, Franco Locatelli, and Peter Bader. "Acute Lymphoblastic Leukemia in Children and Adolescents." In The EBMT Handbook, 539–45. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-030-02278-5_72.

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Waanders, Esmé, Marjolijn C. J. Jongmans, and Charles G. Mullighan. "Molecular Origin of Childhood Acute Lymphoblastic Leukemia." In Etiology of Acute Leukemias in Children, 157–206. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-05798-9_7.

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Dodzik, Peter A., and Randy Fulton. "Neuropsychological Outcomes in Children with Acute Lymphoblastic Leukemia." In Handbook of Long Term Care of The Childhood Cancer Survivor, 223–47. Boston, MA: Springer US, 2015. http://dx.doi.org/10.1007/978-1-4899-7584-3_15.

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Rytting, Michael. "Acute Lymphoblastic Leukemia (ALL) in Children and Adolescents." In Acute Leukemias, 185–92. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-53633-6_12.

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Plouvier, E., P. Herve, A. Noir, M. Flesch, J. Y. Cahn, E. Racadot, P. Henon, et al. "Autologous Bone Marrow Transplantation in Children Acute Lymphoblastic Leukemia." In 11th Annual meeting of the EBMT, 46. Berlin, Heidelberg: Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-662-40457-7_31.

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Pieters, R., T. Hongo, A. H. Loonen, D. R. Huismans, H. J. Broxterman, K. Hählen, and A. J. P. Veerman. "Drug Resistance in Children with Relapsed Acute Lymphoblastic Leukemia." In Acute Leukemias, 321–26. Berlin, Heidelberg: Springer Berlin Heidelberg, 1992. http://dx.doi.org/10.1007/978-3-642-76591-9_51.

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Mehta, Parinda A., and Stella M. Davies. "Hematopoietic Cell Transplantation for Acute Lymphoblastic Leukemia in Children." In Thomas’ Hematopoietic Cell Transplantation, 600–617. Chichester, UK: John Wiley & Sons, Ltd, 2016. http://dx.doi.org/10.1002/9781118416426.ch53.

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Neglia, Joseph P., Maura O’Leary, and Smita Bhatia. "Late Sequelae in Children with Acute Lymphoblastic Leukemia: Impact on Long-Term Survival and Quality of Life." In Childhood Leukemia, 245–63. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-642-13781-5_9.

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Conference papers on the topic "Lymphoblastic leukemia in children Lymphoblastic leukemia in children Cognition in children"

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Müller, J., B. Fedders, G. Cario, M. Schrappe, D. Schewe, A. Möricke, H. Lilljebjörn, T. Fioretos, M. Zimmermann, and M. Stanulla. "Stratification and prognosis of IGH-DUX4 positive acute lymphoblastic leukemia in children." In 32. Jahrestagung der Kind-Philipp-Stiftung für pädiatrisch onkologische Forschung. Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-1687154.

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Bhatia, Smita. "Abstract IA07: Adherence to oral chemotherapy in children with Acute Lymphoblastic Leukemia." In Abstracts: Ninth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; September 25-28, 2016; Fort Lauderdale, FL. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7755.disp16-ia07.

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Glass, John O., Chin-Shang Li, Kathleen J. Helton, and Wilburn E. Reddick. "Computer-aided diagnosis of leukoencephalopathy in children treated for acute lymphoblastic leukemia." In Medical Imaging, edited by J. Michael Fitzpatrick and Joseph M. Reinhardt. SPIE, 2005. http://dx.doi.org/10.1117/12.594650.

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Fetriyah, Umi, Rifa’atul Mahmudah, Alsia Damayanti, and Syamsul Firdaus. "Religiosity, Social Support and Anxiety in Mothers of Children with Acute Lymphoblastic Leukemia." In Proceedings of the Third International Conference on Sustainable Innovation 2019 – Health Science and Nursing (IcoSIHSN 2019). Paris, France: Atlantis Press, 2019. http://dx.doi.org/10.2991/icosihsn-19.2019.27.

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Reddick, Wilburn E., John O. Glass, Kathleen J. Helton, Chin-Shang Li, and Ching-Hon Pui. "Quantitative MRI assessments of white matter in children treated for acute lymphoblastic leukemia." In Medical Imaging, edited by Amir A. Amini and Armando Manduca. SPIE, 2005. http://dx.doi.org/10.1117/12.594622.

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Kroll, M., K. Bleckmann, A. Möricke, D. Schewe, G. Cario, and M. Schrappe. "Methotrexate-associated toxicity during therapy of acute lymphoblastic leukemia in children with Down syndrome." In 31. Jahrestagung der Kind-Philipp-Stiftung für pädiatrisch onkologische Forschung. Georg Thieme Verlag KG, 2018. http://dx.doi.org/10.1055/s-0038-1644991.

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Brown, Austin L., Adam J. de Smith, Michael E. Scheurer, Noah A. Kallsen, Shanna A. Peyton, Gareth E. Davies, Erik A. Ehli, et al. "Abstract 222: Genome-wide association study of acute lymphoblastic leukemia in children with Down syndrome." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-222.

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Bdaiwi, Lelas, Luay Al-Helaly, and Sayran Saleh. "Lipids and Glucose in Cerebrospinal Fluid of Children with Acute Lymphoblastic Leukemia and Hydrocephalus Disease." In 2018 International Conference on Pure and Applied Science. Koya University, 2018. http://dx.doi.org/10.14500/icpas2018.bph88.

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Ishimaru, Sae, Yuya Saito, Yuichi Yokokawa, Yuki Yuza, Takashi Kaneko, and Mitsuyoshi Urashima. "Abstract A9: Uridine diphospho glucuronosyl-transferase 2B17 genotype and a risk of acute lymphoblastic leukemia and lymphoblastic lymphoma among Japanese children." In Abstracts: AACR Special Conference: Pediatric Cancer at the Crossroads: Translating Discovery into Improved Outcomes; November 3-6, 2013; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.pedcan-a9.

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Ramsey, Laura B., Katherine M. Robinson, Jitesh D. Kawedia, Wenjian Yang, Chengcheng Liu, John C. Panetta, Sima Jeha, et al. "Abstract CT409: Dexamethasone (dex) and asparaginase increase triglycerides during acute lymphoblastic leukemia (ALL) therapy in children." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-ct409.

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