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Journal articles on the topic 'Lymphocyte precursors, chronic inflammation, autoimmune diseases'

Author: Grafiati

Published: 11 March 2023

Last updated: 31 July 2025

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1

Martin Calderon, L., and J. Pope. "AB0721 From Undifferentiated Connective Tissue Disease to Identifiable Disease: Precursors of Systemic Sclerosis and Systemic Lupus Erythematosus." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1487.3–1488. http://dx.doi.org/10.1136/annrheumdis-2022-eular.4241.

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BackgroundThe pathogenesis of systemic lupus erythematosus and systemic sclerosis is characterized by derangements of the innate and adaptive immune systems, and inflammatory pathways leading to autoimmunity, chronic cytokine production, and chronic inflammation. Diagnosis is rooted in meeting established criteria. However, in pre-clinical states criteria is not fulfilled but biochemical and autoimmune derangements are present. Understanding the underlying processes responsible for disease pathogenesis in pre-clinical states, which place patients at increased risk for the development of establ

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Sesti-Costa, Renata, Carolina Lanaro, Dulcinéia Martins de Albuquerque, Sara T. Olalla Saad, and Fernando Ferreira Costa. "Sickle Cell Disease Patients Have Altered Number and Function of Dendritic Cells." Blood 134, Supplement_1 (2019): 3569. http://dx.doi.org/10.1182/blood-2019-129854.

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Dendritic cells (DCs) are the sentinels of the immune system able to recognize pathogen- and damage-associated molecular patterns (PAMPs and DAMPs), promoting a bridge between the innate and adaptive immune systems. They form a heterogeneous group of cells with different development, phenotype and functions, and they are mainly classified in conventional DCs 1 (cDC1) and 2 (cDC2), plasmacytoid DCs (pDC) and inflammatory DCs. Changes in the development of DCs, in the ratio of the subsets or in the maturation and activation can impair immunity or tolerance, inducing susceptibility to infections,

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Weinberg, J. Brice, David J. DiLillo, Yohei Iwata, et al. "Chronic Lymphocytic Leukemia Shares a Common Cellular Origin with Regulatory B10 Cells." Blood 118, no. 21 (2011): 286. http://dx.doi.org/10.1182/blood.v118.21.286.286.

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Abstract Abstract 286 Background: The cell of origin of CLL is unknown. Researchers have proposed various B cell subsets as the normal counterparts based on surface marker similarities or Ig gene utilization comparisons of normal and CLL cells. Regulatory B lymphocytes (“B10” cells), with the capacity to produce IL-10, negatively regulate T cell, B cell, and mononuclear phagocyte function. CLL patients are immunosuppressed with abnormalities in both humoral and cellular immunity. B10 cells have a phenotype similar to CLL cells (CD24hiCD27+CD5+CD19+). B10 cells are increased in autoimmune mice

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Gray, Kathryn J., and Julie E. Gibbs. "Adaptive immunity, chronic inflammation and the clock." Seminars in Immunopathology 44, no. 2 (2022): 209–24. http://dx.doi.org/10.1007/s00281-022-00919-7.

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Abstract The adaptive arm of the immune system facilitates recognition of specific foreign pathogens and, via the action of T and B lymphocytes, induces a fine-tuned response to target the pathogen and develop immunological memory. The functionality of the adaptive immune system exhibits daily 24-h variation both in homeostatic processes (such as lymphocyte trafficking and development of T lymphocyte subsets) and in responses to challenge. Here, we discuss how the circadian clock exerts influence over the function of the adaptive immune system, considering the roles of cell intrinsic clockwork

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Tomczyńska, Małgorzata, and Joanna Saluk-Bijak. "The mutual cooperation of blood platelets and lymphocytes in the development of autoimmune thyroid diseases." Acta Biochimica Polonica 65, no. 1 (2018): 17–24. http://dx.doi.org/10.18388/abp.2017_2321.

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Autoimmune thyroid diseases include several distinct clinical entities and mainly concern Graves` disease and Hashimoto's thyroiditis. An incompetent immune response directed against the body’s own tissues and the production of antibodies against specific cell antigens, accompanied by chronic inflammation occur in autoimmune thyroid diseases. The autoimmune process is induced by difficult to identify genetic and environmental factors, and generates the development of concomitant diseases of other systems. The inflammatory mediators, high level of thyroid hormones, lymphocyte activation and oth

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Meller, Agnieszka, Wioletta Pawlukowska, Karolina Machowska-Sempruch, and Masztalewicz Marta. "Spectrum of Autoimmune Diseases—Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids (CLIPPERS)—Clinical Case." Medicina 59, no. 3 (2023): 549. http://dx.doi.org/10.3390/medicina59030549.

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Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) syndrome is a rare inflammatory disease of an undetermined aetiology. The condition is characterised by a range of clinical manifestations generally associated with damage to brainstem structures, the cerebellum, with characteristic magnetic resonance imaging (MRI) findings. The main feature is a good clinical and radiological response to glucocorticosteroid (GCS)-based immunosuppressive treatment. The diagnosis of CLIPPERS is difficult and requires extensive differential diagnosis. A speci

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Hwang, Il-Young, Chung Park, Kathleen Harrison, and John H. Kehrl. "TLR4 signaling augments B lymphocyte migration and overcomes the restriction that limits access to germinal center dark zones." Journal of Experimental Medicine 206, no. 12 (2009): 2641–57. http://dx.doi.org/10.1084/jem.20091982.

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B lymphocyte–intrinsic Toll-like receptor (TLR) signals amplify humoral immunity and can exacerbate autoimmune diseases. We identify a new mechanism by which TLR signals may contribute to autoimmunity and chronic inflammation. We show that TLR4 signaling enhances B lymphocyte trafficking into lymph nodes (LNs), induces B lymphocyte clustering and interactions within LN follicles, leads to sustained in vivo B cell proliferation, overcomes the restriction that limits the access of nonantigen-activated B cells to germinal center dark zones, and enhances the generation of memory and plasma cells.

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Wongkar, Martini, Handoko Lowis, Sarah M. Warouw, Julius Lolombulan, and Stefanus Gunawan. "Blood count to determine chronic inflammation severity in obese adolescents." Paediatrica Indonesiana 60, no. 1 (2020): 6–12. http://dx.doi.org/10.14238/pi60.1.2020.6-12.

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Background Obesity is a growing public health problem of rapidly increasing prevalence in developing countries. Chronic low-grade inflammation plays a key role in the pathophysiology of obesity. Blood count values and ratios have been used as markers of inflammatory diseases. These parameters may be useful to determine the severity of chronic inflammation in obese children. Objective To determine if red blood cell distribution width (RDW), neutrophil-to-lymphocyte ratio (NLR), mean platelet volume (MPV), platelet distribution width (PDW), and platelet-to-lymphocyte ratio (PLR) can be use

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Emmanuel K, Mugisha. "Adaptive Immunity and Autoimmune Disease: Mechanisms, Pathogenesis, and Therapeutic Approaches." NEWPORT INTERNATIONAL JOURNAL OF BIOLOGICAL AND APPLIED SCIENCES 5, no. 3 (2024): 44–48. https://doi.org/10.59298/nijbas/2024/5.3.444811.

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Autoimmune diseases arise when the adaptive immune system mistakenly targets self-antigens, leading to chronic inflammation and tissue damage. This review explores the mechanisms by which adaptive immunity, particularly T and B lymphocyte responses, contributes to the development and persistence of autoimmune diseases. It examines the underlying factors that influence autoreactivity, including genetic susceptibility, environmental triggers, and breakdowns in immune tolerance. Additionally, we discuss the role of T cells, B cells, and autoantibodies in various autoimmune diseases, with emphasis

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Conti, Pio, Luisa Stellin, Alesssandro Caraffa, et al. "Advances in Mast Cell Activation by IL-1 and IL-33 in Sjögren’s Syndrome: Promising Inhibitory Effect of IL-37." International Journal of Molecular Sciences 21, no. 12 (2020): 4297. http://dx.doi.org/10.3390/ijms21124297.

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Sjögren’s syndrome (SS) is a chronic autoimmune inflammatory disease that affects primarily older women and is characterized by irreversible damage of the exocrine glands, including tear (xerophthalmia) and salivary glands (xerostomia). Secretory glands lose their functionality due to the infiltration of immune cells, which produce cytokines and cause inflammation. Primary SS is characterized by dry syndrome with or without systemic commitment in the absence of other pathologies. Secondary SS is accompanied by other autoimmune diseases with high activation of B lymphocytes and the production o

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Contaldo, Maria, Mariarosaria Boccellino, Giuseppa Zannini, et al. "Sex Hormones and Inflammation Role in Oral Cancer Progression: A Molecular and Biological Point of View." Journal of Oncology 2020 (June 27, 2020): 1–14. http://dx.doi.org/10.1155/2020/9587971.

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Oral cancers have been proven to arise from precursors lesions and to be related to risk behaviour such as alcohol consumption and smoke. However, the present paper focuses on the role of chronic inflammation, related to chronical oral infections and/or altered immune responses occurring during dysimmune and autoimmune diseases, in the oral cancerogenesis. Particularly, oral candidiasis and periodontal diseases introduce a vicious circle of nonhealing and perpetuation of the inflammatory processes, thus leading toward cancer occurrence via local and systemic inflammatory modulators and via gen

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Tobón, Gabriel J., Jorge H. Izquierdo, and Carlos A. Cañas. "B Lymphocytes: Development, Tolerance, and Their Role in Autoimmunity—Focus on Systemic Lupus Erythematosus." Autoimmune Diseases 2013 (2013): 1–17. http://dx.doi.org/10.1155/2013/827254.

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B lymphocytes are the effectors of humoral immunity, providing defense against pathogens through different functions including antibody production. B cells constitute approximately 15% of peripheral blood leukocytes and arise from hemopoietic stem cells in the bone marrow. It is here that their antigen receptors (surface immunoglobulin) are assembled. In the context of autoimmune diseases defined by B and/or T cell autoreactive that upon activation lead to chronic tissue inflammation and often irreversible structural and functional damage, B lymphocytes play an essential role by not only produ

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Kazama, Itsuro. "Roles of Lymphocyte Kv1.3-Channels in the Pathogenesis of Renal Diseases and Novel Therapeutic Implications of Targeting the Channels." Mediators of Inflammation 2015 (2015): 1–12. http://dx.doi.org/10.1155/2015/436572.

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Delayed rectifier K+-channels (Kv1.3) are predominantly expressed in T lymphocytes. Based on patch-clamp studies, the channels play crucial roles in facilitating the calcium influx necessary to trigger lymphocyte activation and proliferation. Using selective channel inhibitors in experimental animal models,in vivostudies then revealed the clinically relevant relationship between the channel expression and the pathogenesis of autoimmune diseases. In renal diseases, in which “chronic inflammation” or “the overstimulation of cellular immunity” is responsible for the pathogenesis, the overexpressi

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Petryk, Nataliia, and Oleksandr Shevchenko. "CORRELATION BETWEEN THE LYMPHOCYTE-MONOCYTE RATIO AND CYTOKINES IN CHRONIC INFLAMMATION IN RATS TREATED WITH ALLOGENEIC MESENCHYMAL STEM CELLS." Inter Collegas 7, no. 3 (2020): 109–17. http://dx.doi.org/10.35339/ic.7.3.109-117.

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The chronic inflammatory process is a pathological condition characterized by an ongoing active inflammatory response and tissue destruction. Many studies show that chronic inflammation can play a severe role in various age-related diseases, including diabetes, cardiovascular, and autoimmune diseases. One of the important but poorly studied factors affecting the regulation of chronic inflammation is the regulatory activity of MSCs. In this regard, the study of mesenchymal stem cells preventing chronic inflammation in the experiment is an important area of modern pathology. On the one han

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Petryk, Nataliia, and Oleksandr Shevchenko. "CORRELATION BETWEEN THE LYMPHOCYTE-MONOCYTE RATIO AND CYTOKINES IN CHRONIC INFLAMMATION IN RATS TREATED WITH ALLOGENEIC MESENCHYMAL STEM CELLS." Inter Collegas 7, no. 3 (2020): 109–17. http://dx.doi.org/10.35339/ic.7.3.109-117.

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The chronic inflammatory process is a pathological condition characterized by an ongoing active inflammatory response and tissue destruction. Many studies show that chronic inflammation can play a severe role in various age-related diseases, including diabetes, cardiovascular, and autoimmune diseases. One of the important but poorly studied factors affecting the regulation of chronic inflammation is the regulatory activity of MSCs. In this regard, the study of mesenchymal stem cells preventing chronic inflammation in the experiment is an important area of modern pathology. On the one han

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Liadova, Т. І., and F. V. Hladkykh. "Immunological mechanisms of the development of autoimmune gastritis as a precancerous disease of the stomach." Karazin Journal of Immunology, no. 14 (December 29, 2024): 202–11. https://doi.org/10.26565/3083-5615-2024-14-09.

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Background. The gastrointestinal tract is considered the largest immunological organ, as it contains 70% of the body’s lymphocyte population. The prevalence of concomitant autoimmune diseases in patients with autoimmune arthritis reaches 40%, and the most common diseases are thyroid gland diseases, type 1 diabetes, hemolytic anemia, rheumatoid arthritis, autoimmune hepatitis, myasthenia gravis, Sjogren’s disease, etc. Immune dysregulation plays a key role in the pathogenesis of not only autoimmune diseases, but also neoplastic processes. Purpose – summarize current information about autoimmune

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Moysidou, Eleni, Georgios Lioulios, Aliki Xochelli, et al. "Different Types of Chronic Inflammation Engender Distinctive Immunosenescent Profiles in Affected Patients." International Journal of Molecular Sciences 23, no. 23 (2022): 14688. http://dx.doi.org/10.3390/ijms232314688.

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Immunosenescence encompasses a spectrum of lymphocyte phenotypic alterations. The aim of the study was to evaluate immunosenescent effect of two different forms of chronic inflammation, Systemic Lupus Erythematosous (SLE), a systemic autoimmune disease, and End-Stage Kidney Disease (ESKD), a chronic inflammatory disorder. Certain lymphocyte surface molecules, including CD31, CD45RA, CCR7, CD28, CD57, for T, and IgD, CD27 for B lymphocytes, were analyzed by flow cytometry in 30 SLE and 53 ESKD patients on hemodialysis (HD), and results were compared to 31 healthy controls (HC) of similar age, g

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Hasiakos, S., Y. Gwack, M. Kang, and I. Nishimura. "Calcium Signaling in T Cells and Chronic Inflammatory Disorders of the Oral Cavity." Journal of Dental Research 100, no. 7 (2021): 693–99. http://dx.doi.org/10.1177/0022034521990652.

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Acute immune responses to microbial insults in the oral cavity often progress to chronic inflammatory diseases such as periodontitis and apical periodontitis. Chronic oral inflammation causes destruction of the periodontium, potentially leading to loss of the dentition. Previous investigations have demonstrated that the composition of oral immune cells, rather than the overall extent of cellular infiltration, determines the pathological development of chronic inflammation. The role of T lymphocyte populations, including Th1, Th2, Th17, and Treg cells, has been extensively described. Studies no

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Velozo, Leosvaldo S. M., Thiago Martino, Mariana V. Vigliano, et al. "Pterodon polygalaeflorusEssential Oil Modulates Acute Inflammation and B and T Lymphocyte Activation." American Journal of Chinese Medicine 41, no. 03 (2013): 545–63. http://dx.doi.org/10.1142/s0192415x13500390.

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The increased life expectancy of the population has led to increasing incidences of cancer, chronic inflammatory and autoimmune diseases. Thus the continuous search for new drugs is necessary because ineffectiveness and adverse effects have been described for standard drugs. Essential oils are important sources of bioactive metabolites and several clinical trials have been developed using them. The Pterodon genus has been used in traditional medicine to treat rheumatic disorders, thus this work investigated the properties of essential oil from Pterodon polygalaeflorus fruits (EsOPpg) on acute

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Mititelu, Radu Răzvan, Rodica Pădureanu, Manuela Băcănoiu, et al. "Inflammatory and Oxidative Stress Markers—Mirror Tools in Rheumatoid Arthritis." Biomedicines 8, no. 5 (2020): 125. http://dx.doi.org/10.3390/biomedicines8050125.

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Rheumatoid arthritis (RA) is a chronic progressive autoimmune disease, associated with significant morbidity, mainly due to progressive damage and consequent disability. Oxidative stress is an important part of RA pathophysiology, as in autoimmune disease the interaction between immune response and endogenous/exogenous antigens subsequently induce the production of reactive oxygen species. The oxidative stress process seems to be positively strongly correlated with inflammation and accelerated joint destruction. We were asking ourselves if the oxidative stress biomarkers are the mirror tools o

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Gokce, Aksanur, Tulay Omma, Mustafa Çelikc, and Işılay Taşkaldıran. "An overview of the hematological picture with antithyroid therapy in Graves' disease." Acta Facultatis Medicae Naissensis 39, no. 4 (2022): 467–75. http://dx.doi.org/10.5937/afmnai39-36192.

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Aim: Graves' disease is an autoimmune thyroid disease that is the most common cause of hyperthyroidism. Peripheral blood cell parameters such as neutrophils, lymphocytes, and platelets play a role in inflammation control. Several studies have proven that neutrophil-lymphocyte ratio, monocyte-lymphocyte ratio and platelet-lymphocyte ratio are indicators of chronic subclinical inflammation in various diseases. In our study, we aimed to review the peripheral blood picture by evaluating these parameters before and after antithyroid treatment in patients with Graves' disease. Patients and methods:

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Domerecka, Weronika, Anna Kowalska-Kępczyńska, Iwona Homa-Mlak, et al. "The Usefulness of Extended Inflammation Parameters and Systemic Inflammatory Response Markers in the Diagnostics of Autoimmune Hepatitis." Cells 11, no. 16 (2022): 2554. http://dx.doi.org/10.3390/cells11162554.

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(1) Introduction: Autoimmune hepatitis (AIH) is a chronic disease. A persistent autoimmune reaction in the liver is significantly related to the systemic inflammatory response. Extended Inflammation Parameters (EIP) can be used to assess the activation of immune cells such as activated neutrophils (NEUT-RI and NEUT-GI) and activated lymphocytes (RE-LYMP and AS-LYMP) in the phase of active inflammation. The role of the systemic inflammatory response markers should also be emphasised, especially: NLR, PLR, and RLR, which have recently been widely studied as markers in autoimmune skin diseases or

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Panebianco, Pierpaolo, Gianluca Testa, Giulia Barbagallo, et al. "The Correlations of the Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio with Bone Mineral Density in Postmenopausal Women: A Cross-Sectional Study." Osteology 5, no. 2 (2025): 14. https://doi.org/10.3390/osteology5020014.

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Background/Objectives: Osteoporosis is a skeletal disorder characterized by reduced bone mineral density (BMD) and increased fracture risk. Chronic inflammation is implicated in osteoporosis pathogenesis, with inflammatory mediators promoting bone resorption. The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are markers of systemic inflammation and have emerged as potential indicators of bone health. This study’s aim was to highlight the potential role of the NLR and PLR as markers of bone health in postmenopausal women affected by osteoporosis or osteopenia and t

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Hashim, Nidhal Abdullah, Younus Jasim Abdullah, and Ali Abdullah Sayhood. "Evaluate the hematologic parameters, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio in patients with autoimmune hypothyroidism from Amara City, Southern Iraq." Medical Journal of Babylon 20, Supplement 1 (2023): S48—S52. http://dx.doi.org/10.4103/mjbl.mjbl_369_22.

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Abstract Background: Thyroid diseases are affecting 3%–5% of the women general population. Autoimmune thyroid diseases such as Graves’ disease (GD) and Hashimoto’s disease were detected to be the commonest disorders affecting thyroid function. Objectives: This study is a case–control study that aimed to estimate the effect of HT on hematological parameters. Materials and Methods: A total of 100 persons (50 HT patients and 50 euthyroid groups) of both sexes aged between 15 and 50 years were included in this study during the period April 2021–April 2022. Samples of venous blood (5 mL) were obtai

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Darrigues, Julie, Joost P. M. van Meerwijk, and Paola Romagnoli. "Age-Dependent Changes in Regulatory T Lymphocyte Development and Function: A Mini-Review." Gerontology 64, no. 1 (2017): 28–35. http://dx.doi.org/10.1159/000478044.

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The generation and function of immuno-suppressive regulatory T lymphocytes (Treg), which can differentiate in the thymus (tTreg) or in the periphery (pTreg), are regulated in an age-dependent manner. tTreg are produced at high levels in the first weeks of age, when they expand and colonize secondary lymphoid organs and peripheral tissues to protect the organism from autoimmune diseases and to promote tissue repair. Once this population of Treg is operational in the periphery, at puberty, thymic output of Treg declines, but self-reactive tTreg generated early on in life are maintained over time

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Surabhi, P., K.C. Ajitha, and K. Sajeesh. "Correlation of Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio with Disease Activity in Patients with Systemic Lupus Erythematosus." International Journal of Toxicological and Pharmacological Research 13, no. 3 (2023): 346–60. https://doi.org/10.5281/zenodo.11263829.

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<strong>Background: </strong>Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease with unknown aetiology and has various clinical manifestations affecting different tissues. Chronic inflammation is an important pathological development in the disease process for autoimmune diseases. <strong>Aims: </strong> To correlate NLR AND PLR with disease activity in SLE, lupus nephritis and with severity of SLE arthritis. <strong>Materials & Methods: </strong>After obtaining institutional approval, a hospital based cross sectional study was conduct

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Chung, Chi-Li, Kam-Wing Leung, Wan-Jung Lu, et al. "Hinokitiol Negatively Regulates Immune Responses through Cell Cycle Arrest in Concanavalin A-Activated Lymphocytes." Evidence-Based Complementary and Alternative Medicine 2015 (2015): 1–8. http://dx.doi.org/10.1155/2015/595824.

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Autoimmune diseases are a group of chronic inflammatory diseases that arise from inappropriate inflammatory responses. Hinokitiol, isolated from the wood ofChamaecyparis taiwanensis, engages in multiple biological activities. Although hinokitiol has been reported to inhibit inflammation, its immunological regulation in lymphocytes remains incomplete. Thus, we determined the effects of hinokitiol on concanavalin A- (ConA-) stimulated T lymphocytes from the spleens of mice. In the present study, the MTT assay revealed that hinokitiol (1–5 μM) alone did not affect cell viability of lymphocytes, b

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Striz, Ilja. "Cytokines of the IL-1 family: recognized targets in chronic inflammation underrated in organ transplantations." Clinical Science 131, no. 17 (2017): 2241–56. http://dx.doi.org/10.1042/cs20170098.

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Interleukin 1 (IL-1) family is a group of cytokines with multiple local and systemic effects, which regulates both innate and adaptive immune responses. Generally, most IL-1 family cytokines express prevailing pro-inflammatory activities (IL-1α, IL-1β, IL-18, IL-33, IL-36 α, β, γ), whereas others are anti-inflammatory (IL-1Ra (IL-1 receptor antagonist), IL-36Ra, IL-38, IL-37). In addition to their immunomodulatory roles, some of them are also involved in the physiological modulation of homeostatic processes and directly affect mRNA transcription. IL-1 family cytokines bind to specific receptor

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Gašić, Sanja, Milica Perić, Tamara Matić, Teodora Jorgaćević, and Slađana Ilić. "Assessment of neutrophil-lymphocyte and platelet-lymphocyte ratio in patients with hashimoto's thyroiditis." Praxis medica 51, no. 1-2 (2022): 15–19. http://dx.doi.org/10.5937/pramed2202015g.

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INTRODUCTION: The ratio of neutrophils-lymphocytes (NLR) and platelet-lymphocytes (PLR) is a new parameter in the assessment of patients with Hashimoto's thyroiditis OBJECTIVE: The aim of this study was to investigate the effect of NLR and PLR in patients with Hashimoto's thyroiditis MATERIALS AND METHODS: In this cross-sectional study, subjects were subjected to tests of thyroid gland function, antithyroid antibodies, as well as laboratory analyzes of blood count with determination of NLR and PLR. The respondents were grouped into two groups. The first group was patients with Hashimoto's thyr

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Wang, Aline Yen Ling, Ana Elena Aviña, Yen-Yu Liu, Yun-Ching Chang, and Huang-Kai Kao. "Transcription Factor Blimp-1: A Central Regulator of Oxidative Stress and Metabolic Reprogramming in Chronic Inflammatory Diseases." Antioxidants 14, no. 2 (2025): 183. https://doi.org/10.3390/antiox14020183.

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B-lymphocyte-induced maturation protein 1 (Blimp-1) is a transcription factor that, among other functions, modulates metabolism and helps to regulate antioxidant pathways, which is important in the context of chronic inflammatory diseases like diabetes, cardiovascular disease, and autoimmune disease. In immune cell function, Blimp-1 has a modulatory role in the orchestration of metabolic reprogramming and as a promoter of anti-inflammatory cytokines, including IL-10, responsible for modulating oxidative stress and immune homeostasis. Moreover, Blimp-1 also modulates key metabolic aspects, such

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Liao, Yi-Chu, and Chi-Chang K. Shieh. "NOX2-deficient neutrophils facilitate joint inflammation in serum-induced arthritis." Journal of Immunology 204, no. 1_Supplement (2020): 219.5. http://dx.doi.org/10.4049/jimmunol.204.supp.219.5.

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Abstract Immune-mediated inflammatory arthritis, including rheumatoid arthritis (RA), is a family of chronic inflammatory diseases of joints. NADPH oxidases 2 (NOX2) complex in phagocytes generates high concentrations of ROS to kill the engulfed microbes. Inherited mutations in the subunits of NOX2 result in chronic granulomatous disease (CGD). Subjects with defective NOX2 are susceptible to recurrent infections and a variety of autoimmune conditions. According to our previous studies, NOX2-deficient mice developed more severe immune-mediated arthritis, but depletion of neutrophils suppressed

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Cetin, Yasin, Nafiye Fulya Ilhan, Deniz Sen, and Sevim Karakas Celik. "The investigation of BTLA single-nucleotide polymorphisms in patients with Behcet disease in Elazıg province." Turkish Journal of Biochemistry 45, no. 3 (2020): 323–27. http://dx.doi.org/10.1515/tjb-2019-0221.

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AbstractObjectiveBehcet Disease (BD) is a systemic chronic autoinflammatory disorder that significantly increases mortality and morbidity. Although B- and T-lymphocyte attenuator (BTLA) is important in regulating lymphocyte activation during inflammation and infection, it is unclear whether any polymorphism in the gene encoding the BTLA is associated with autoimmune diseases and cancer. The goal of the study was to research the relationship between the alleles, genotypes and haplotypes frequencies of chosen BTLA gene polymorphisms (rs184489 and rs9288952) and the risk of Behcet disease.Materia

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Yang, Ming, and Chun-Ye Zhang. "Interleukins in liver disease treatment." World Journal of Hepatology 16, no. 2 (2024): 140–45. http://dx.doi.org/10.4254/wjh.v16.i2.140.

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Cytokines play pleiotropic roles in human health and disease by regulating both innate and adaptive immune responses. Interleukins (ILs), a large group of cytokines, can be divided into seven families, including IL-1, IL-2, IL-6, IL-8, IL-10, IL-12, and IL-17 families. Here, we review the functions of ILs in the pathogenesis and resolution of liver diseases, such as liver inflammation (e.g. , IL-35), alcohol-related liver disease (e.g. , IL-11), non-alcoholic steatohepatitis (e.g. , IL-22), liver fibrosis (e.g. , Il-17a), and liver cancer (e.g. , IL-8). Overall, IL-1 family members are implica

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Yeloyeva, Z.V., L.P. Kiselyova, T.O. Filonova, et al. "Autoimmune rheumatic diseases and autoinflammatory syndromes, facets of contact." Annals of Mechnikov Institute, no. 4 (December 21, 2020): 21–30. https://doi.org/10.5281/zenodo.4382141.

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The peculiarity of the development of inflammation, its acute and chronic course, various combinations of inflammatory mediators, the nature and severity of the immune response is largely arise from the genetic characteristics of the organism. It would be logical to assume the key role of small mutations of genes in initiating the development of autoaggression, activation of signaling molecules, immunocompetent cells with violation of their cooperation, production of pro-inflammatory cytokines, as a consequence of the effect of persistent viral-bacterial infection and non-infectious agents. In

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Berglová, Irena, Jan Krejsek, Martina Koláčková, and Radovan Slezák. "B Cell Toll-like Receptors with Respect to the Pathogenesis of Sjögren’s Syndrome." Acta Medica (Hradec Kralove, Czech Republic) 54, no. 2 (2011): 51–57. http://dx.doi.org/10.14712/18059694.2016.18.

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Sjőgren’s syndrome (SS) is a chronic autoimmune immunopathological disease of unknown aetiology. It is characterized by focal lymphocyte infiltration and inflammation in exocrinne glands, involving especially salivary and lacrimal glands. Hypofunction of the glands leads to the decreased glandular secretion together with impaired production of saliva and tears, resulting in dryness of the mouth and eyes (xerostomia and xerophthalmia, respectively). Some of the studies have suggested that Toll-like receptors and B cells play a pivotal role in the pathogenesis of autoimmune diseases such as syst

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Shao, Wenwei, Weilin Huang, Yixuan Wang, et al. "Exosome-Modified AAV Gene Therapy Attenuates Autoimmune Hepatitis via Enhanced Regulatory T Cell Targeting and Immune Modulation." Microorganisms 13, no. 4 (2025): 823. https://doi.org/10.3390/microorganisms13040823.

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Autoimmune hepatitis (AIH) is a chronic liver disorder driven by immune dysregulation, marked by reduced regulatory T cells (Tregs) and unchecked inflammation. Current therapies lack specificity and efficacy, necessitating novel approaches. This study explores gene therapy using exosome-associated adeno-associated virus (exo-AAV) to deliver the Foxp3 gene, aiming to restore Treg-mediated immune tolerance in AIH. We engineered exosomes expressing the CD4-targeting antibody on their surface, encapsulating AAV6/Foxp3, to enhance lymphoid cell specificity. In a ConA-induced murine AIH model, engin

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Derakhshani, Afshin, Zahra Asadzadeh, Hossein Safarpour та ін. "Regulation of CTLA-4 and PD-L1 Expression in Relapsing-Remitting Multiple Sclerosis Patients after Treatment with Fingolimod, IFNβ-1α, Glatiramer Acetate, and Dimethyl Fumarate Drugs". Journal of Personalized Medicine 11, № 8 (2021): 721. http://dx.doi.org/10.3390/jpm11080721.

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Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system (CNS) that is characterized by inflammation which typically results in significant impairment in most patients. Immune checkpoints act as co-stimulatory and co-inhibitory molecules and play a fundamental role in keeping the equilibrium of the immune system. Cytotoxic T-lymphocyte antigen-4 (CTLA-4) and Programmed death-ligand 1 (PD-L1), as inhibitory immune checkpoints, participate in terminating the development of numerous autoimmune diseases, including MS. We assessed the CTLA-4 and PD-L1 gene expression

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Blomberg, Bonnie, Alain Diaz, Maria Romero, and Daniela Frasca. "Old mice and elderly humans make increased autoimmune antibodies, inflammation and SASP from aged-increased B cells (ABCs in mice and DN in humans) which are hypermetabolic." Journal of Immunology 208, no. 1_Supplement (2022): 108.05. http://dx.doi.org/10.4049/jimmunol.208.supp.108.05.

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Abstract Immune mechanisms of human and murine diseases of aging include generation of chronic inflammation and autoimmunity. We and others have associated aging in mice and humans with increased chronic inflammation, reduced vaccine response and an increase in a B lymphocyte subset referred to as Age-associated B cells (ABCs) in mice and DN (double negative) in humans. Immune cell function is dependent on metabolic pathways and to date understudied. A. In this work we sorted splenic ABCs (CD19+AA4.1-CD21-CD23−) from young (3–4 months) and old (18–22 months) C57BL/6 mice showing an increased p

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Li, Yajuan, Mei Yan, Yong Du, Soyoun Min, Chandra Mohan, and Quanzhen Li. "The anti-oxidative role of glutathione s-transferase mu 2 in anti-GBM induced glomerulonephritis by inhibiting inflammation and oxidative stress (P5121)." Journal of Immunology 190, no. 1_Supplement (2013): 137.2. http://dx.doi.org/10.4049/jimmunol.190.supp.137.2.

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Abstract Oxidative stress is a common manifestation in chronic inflammation and closely associated with autoimmune diseases. Impaired balance between oxidative stress and antioxidant systems exhibits an important impact on pathogenesis of immune-mediated nephritis. Using anti-GBM induced nephritis mouse model, we have identified a group of redox related genes dysregulated in mouse kidney upon anti-GBM antibody challenge. In this study, we investigated the anti-oxidative effect of glutathione s-transferase mu 2 (Gstm2) on immune-mediated nephritis. Human GSTM2 gene was transduced into mesenchym

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Kawajiri, Akihisa, Jing Li, Ziying Yang, et al. "Self antigen-driven, undifferentiated memory-phenotype CD4 T lymphocytes can induce mild and systemic inflammation by differentiating into effector and regulatory T cells." Journal of Immunology 210, no. 1_Supplement (2023): 76.09. http://dx.doi.org/10.4049/jimmunol.210.supp.76.09.

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Abstract In adaptive immune responses, naïve CD4 +T lymphocytes that have T cell receptors (TCRs) reactive to challenged foreign antigens are activated to differentiate into antigen-specific effector and memory cells. We have recently reported that in steady state, peripheral naïve precursors can also recognize self antigens to spontaneously acquire a memory phenotype (MP) and that such naturally arising “MP cells” can exert innate immune function in host defense. Given the self-reactivity of MP cells, it is likely that the same T lymphocyte population also has the capacity to induce autoimmun

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Faraj, Yusur Falah, Khalid Mahdi Salih, and Abderrahim Khelif. "Some Hematological Indices as Predictors of Survival in Chronic Myeloid Leukemia Patients." Mustansiriya Medical Journal 23, no. 1 (2024): 38–44. http://dx.doi.org/10.4103/mj.mj_14_24.

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Abstract Background: Despite the promising of introduction of tyrosine kinase inhibitors (TKIs), chronic myeloid leukemia (CML) remains a significant cause of annual mortality. Red blood cell distribution width (RDW), neutrophil/lymphocyte ratio (NLR), and platelet/lymphocyte ratio (PLR) are parameters derived from a complete blood count (CBC) commonly used to diagnose anemia, autoimmune diseases, and inflammation. These parameters have been reported to have a strong association with various diseases, including hematologic malignancies. Objectives: The study aims to identify whether RDW, NLR,

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Uvarova, A. N., A. S. Ustiugova, E. A. Zheremyan, E. M. Stasevich, K. V. Korneev, and D. V. Kuprash. "Functional characteristics of the gene promoters of anti-inflammatory cytokines TGF-b and IL-10 in B lymphocyte cell models." Medical Immunology (Russia) 26, no. 4 (2024): 701–6. http://dx.doi.org/10.15789/1563-0625-fco-16940.

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B cells play a crucial role in the pathogenesis of various diseases, such as autoimmune disorders, cancers, and infections. Unlike regulatory T cells, the anti-inflammatory capabilities of B cells have only recently garnered attention. Cytokines IL-10 and TGF-β are among the key secreted immunosuppressive factors, therefore studying the characteristics of their transcriptional regulation in B cells appears to be a relevant task. This study focuses on characterizing the promoter regions of IL10 and TGFB1 genes in immortalized B cell lines representing different developmental stages – Reh and Ra

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Savasan, Sureyya, Batool Al-Qanber, Steven Buck, Erin Wakeling, and Manisha Gadgeel. "Clonal T-Large Granular Lymphocyte Proliferations in Childhood: Friend or Foe?" Blood 132, Supplement 1 (2018): 3719. http://dx.doi.org/10.1182/blood-2018-99-119124.

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Abstract Background: The pathophysiology of clonal T-large granular lymphocyte (T-LGL) proliferations is not well understood; the distinction between reactive and malignant entities is not very clear given the fact that acquired STAT3 mutations can be seen with clonal T-LGL proliferations in non-malignant Felty syndrome and with frequent use of immunosuppression for the treatment of T-LGL leukemia. Historically, determination of clonality has been often seen as an indicator of T-LGL leukemia. We reviewed our experience on clonal T-LGL proliferations in children. Material and Methods: T-LGLs we

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Skupnevsky, S. V., E. G. Pukhaeva, A. K. Badtiev, F. K. Rurua, F. E. Batagova, and Z. G. Farnieva. "Metabolic changes of lymphocytes in a rat model of autoimmunity." Medical Immunology (Russia) 24, no. 2 (2022): 247–56. http://dx.doi.org/10.15789/1563-0625-mco-2408.

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Autoimmune diseases are highly prevalent in humans, being characterized by early onset and high risks of disability, thus determining the relevance of the present work and its aim, i.e., studying metabolic characteristics of lymphocytes upon the adjuvant-induced autoimmune disorder in rats. Modeling of the autoimmune process was performed in Wistar rats by subcutaneous administration of a Freund’s complete adjuvant, i.e., water-oil emulsion with heat-killed M. tuberculosis. Hematology testing (complete blood counts), biochemical markers (hydroperoxides, malondialdehyde (MDA), catalase), and cy

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Hsieh, Y. T., C. Hubeau, V. Massa, et al. "OP0316 EMERGING BEST-IN-CLASS IL-2 VARIANT HIGHLIGHTS TREG-DIRECTED THERAPY FOR AUTOIMMUNE DISEASE." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 195.1–195. http://dx.doi.org/10.1136/annrheumdis-2020-eular.1999.

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Background:Impairment or deficiency of regulatory T cells (Treg) is associated with chronic inflammation and autoimmune diseases. Interleukin 2 (IL-2) is a cytokine indispensable for Treg expansion and immunosuppressive function. However, expansion of cytotoxic effector T (Teff) and NK cells and the associated vascular leakage side effect limit the use of IL-2 in autoimmune diseases [1].Objectives:Cugene developed a long-acting IL-2 variant with high Treg specificity and low toxicity to restore immune homeostasis and self-tolerance, and potentially cure autoimmune and inflammatory diseases.Met

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Yang, Fan, Yan Yan, Zeyu Xiong, Irene H. Chen, Hong Wang, and Xiao-Feng Yang. "Novel Model of Stimulation-Responsive Splicing for Generation of Immunogenic Isoforms of Tumor Antigens and Autoantigens." Blood 108, no. 11 (2006): 5188. http://dx.doi.org/10.1182/blood.v108.11.5188.5188.

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Abstract Alternative splicing is a process that removes introns and alters exons to generate multiple isoforms from a single pre-mRNA transcript. Alternative splicing is the major mechanism by which a small number of human genes (6 × 104) can encode the larger complexity of the human proteome (1 × 106 proteins). Previously we demonstrated that alternative splicing of apoptosis-regulatory protein transcripts regulates immune responses by modulating lymphocyte survival (Immunity, 1997; Mol. Immunol. 2002; J Exp Med, 2002; Oncogene 2005; Biochem J, 2005). To examine the hypothesis that alternativ

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Ismaiel, Abdulrahman, Evrard Katell, Daniel-Corneliu Leucuta, et al. "The Impact of Non-Invasive Scores and Hemogram-Derived Ratios in Differentiating Chronic Liver Disease from Cirrhosis." Journal of Clinical Medicine 14, no. 9 (2025): 3072. https://doi.org/10.3390/jcm14093072.

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Background: Chronic liver disease (CLD) is a major global health concern, contributing significantly to morbidity and mortality. Cirrhosis and liver cancer are the leading causes of liver-related deaths, with various etiological factors, such as metabolic disorders and alcohol-related and viral hepatitis, driving its global prevalence. Non-invasive biomarkers and scoring systems have emerged as key tools for assessing liver disease severity and differentiating CLD from cirrhosis. This study evaluates biomarkers and non-invasive scores and their utility in distinguishing CLD from cirrhosis. Met

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Demchenko, E. N., E. D. Gavrilova, E. V. Goiman, N. N. Volskiy, and V. A. Kozlov. "Dynamics of cell-free DNA levels in the in vivo LPS-induced inflammation model." Russian Journal of Immunology 25, no. 4 (2022): 423–30. http://dx.doi.org/10.46235/1028-7221-1179-doc.

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An increased concentration of extracellular cell free DNA (cfDNA) is a distinctive characteristic of pathologies that mainly occur in acute inflammation (myocardial infarction, sepsis, stroke, trauma). The increase of cfDNA in chronic inflammatory processes, oncological, autoimmune diseases is less significant and is mainly due to aberrant cell death processes. One of such diseases is systemic lupus erythematosus (SLE). It has recently been shown that, in addition to increased cfDNA concentration, the degree of inflammation can reflect the N/L index (neutrophil to lymphocyte ratio), being a si

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Shi, X., and L. Pan. "AB0738 ELEVATED PLATELET COUNT IS A RISK FACTOR FOR REFRACTORY TAKAYASU ARTERITIS." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1575.1–1575. http://dx.doi.org/10.1136/annrheumdis-2023-eular.1197.

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BackgroundTakayasu arteritis (TAK) is a chronic systemic vasculitis that mainly affects the aorta and its major branches. This chronic relapsing disease is relevant to significant morbidity and treatment remains challenging [1]. Early identification of refractory TAK is helpful to improve the long-term prognosis of the disease. In recent years, platelets have been recognized as important markers for various types of diseases [2]. Platelet counts may indicate the activity of autoimmune disease as well as responsiveness to anti-inflammatory therapy and presence of various comorbidities [3]. Mult

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Al-Awadhi, Adel M., Mohammad Z. Haider, Jalaja Sukumaran, Eman AH Hasan, and Youssef A. Bartella. "The Protein Tyrosine Phosphatase Non-receptor Type N22 (PTPN22) Gene Functional Polymorphism (1858T) is not Associated with Rheumatoid Arthritis in Kuwaiti Patients." Open Rheumatology Journal 15, no. 1 (2021): 45–50. http://dx.doi.org/10.2174/1874312902115010045.

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Background: Rheumatoid Arthritis (RA) is a chronic disorder characterized by an inflammation of synovial tissue in joints resulting in pain, deformities and affects the quality of life. The gene for protein tyrosine phosphatase non-receptor type 22 (PTPN22) encodes a lymphoid specific phosphatase (LYP), which serves as a negative regulator of T lymphocyte activation and is associated with a number of autoimmune/chronic diseases in various ethnic groups. Objective: This study was undertaken to investigate an association between PTPN22 gene functional polymorphism (C1858T; rs2476601) and rheumat

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