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Dissertations / Theses on the topic 'Lymphocyte therapy'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

CARRIGLIO, NICOLA. "Preclinical gene therapy studies, altered lymphocyte development and function in ADA-SCID." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2012. http://hdl.handle.net/2108/209654.

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Genetic defects in the adenosine deaminase (ADA) gene are among the most common causes for severe combined immunodeficiency (SCID). ADA-SCID patients suffer from lymphopenia, absent cellular and humoral immunity, recurrent infections and autoimmune manifestations in milder forms. Currently available therapeutic options for this otherwise fatal disorder include bone marrow transplantation (BMT), enzyme replacement therapy with bovine ADA (PEG-ADA) or hematopoietic stem cell gene therapy (GT). The overall aims of my this thesis were to evaluate the preclinical safety of HSC gene therapy a

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2

Debant, Marjolaine. "Etude de la dérégulation des entrées calciques du lymphocyte B de leucémie lymphoïde chronique : mise en évidence d'une nouvelle piste thérapeutique." Thesis, Brest, 2017. http://www.theses.fr/2017BRES0150.

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La leucémie lymphoïde chronique (LLC) constitue l'hémopathie maligne la plus fréquente dans les pays occidentaux et résulte d’une accumulation de lymphocytes B (LB) monoclonaux matures porteurs de la glycoprotéine CD5. Les LB de LLC sont également caractérisées par une altération de l'homéostasie du calcium avec, d'une part, la mise en évidence de facteurs de survie contrôlés par le calcium tels que phospho-ERK, NFAT-2 et IL-10, et d'autre part par une progression de la maladie qui est associée à la réponse au calcium. Tout d'abord, afin de mieux comprendre l'impact de la molécule CD5 sur les

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3

De, Milito Angelo. "Immune activation during HIV-1 infection : implication for B cell dysfunctions and therapy monitoring /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-170-5.

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4

Martens, Lawrence S. A. "The effects of exogenous 5-aminolevulinic acid-induced protoporphyrin IX photodynamic therapy on human lymphocyte cell-mediated cytotoxicity." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp04/mq20670.pdf.

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5

Coque, Emmanuelle. "La neuroimmunité dans la sclérose latérale amyotrophique." Thesis, Montpellier, 2017. http://www.theses.fr/2017MONTT095.

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La sclérose latérale amyotrophique (SLA) est une maladie neurodégénérative incurable caractérisée par la perte sélective des motoneurones du cerveau et de la moelle épinière. Elle se manifeste par une faiblesse musculaire qui évolue vers une paralysie, entrainant la mort du patient dans les 3 à 5 ans après l’apparition des symptômes. Une réponse inflammatoire associée à l'accumulation de cellules immunitaire dans le système nerveux central (SNC) est une signature de la SLA. Ce travail propose d'étudier le rôle des cellules résidentes du SNC, notamment les astrocytes, et des cellules immunitair

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Momin, Mohammad Yahya [Verfasser], and Udo [Akademischer Betreuer] Bakowsky. "Polymeric Photosensitizer Nanocomplex Encapsulated T-lymphocyte Delivery System for Photodynamic Therapy of Cancer / Mohammad Yahya Momin ; Betreuer: Udo Bakowsky." Marburg : Philipps-Universität Marburg, 2017. http://d-nb.info/1130323080/34.

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7

Ngandu, Jean Pierre Kabue. "Coreceptor expression and T lymphocyte subset distribution in HIV-infected and TB co-infected South African patients on anti-retroviral therapy." Thesis, Stellenbosch : University of Stellenbosch, 2009. http://hdl.handle.net/10019.1/2219.

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Thesis (MScMedSc (Pathology. Medical Virology))--University of Stellenbosch, 2009.<br>ENGLISH ABSTRACT: In 2007, AIDS caused an estimated 2.1 millions deaths worldwide; about 70% in sub-Saharan Africa. HIV preferentially targets activated CD4 T cells, expressing the major HIV receptor CD4, as well as the major chemokine coreceptors CCR5 and CXCR4. These coreceptors play a prominent role during HIV cell entrance phase, HIV transmission and also disease progression. They have been found to be differentially expressed by CD4 T cell subsets. Tuberculosis coinfection may enhance immune activat

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8

Cha, Esther. "MARRYING IMMUNOTHERAPY AND CHEMOTHERAPY: A CANCER THERAPY BASED ON T LYMPHOCYTE EXPANSION AUGMENTED BY ALTERNATE GAMMA CHAIN CYTOKINES AND GEMCITABINE-MEDIATED INHIBITION OF MYELOID DERIVED SUPPRESSOR CELLS." VCU Scholars Compass, 2009. http://scholarscompass.vcu.edu/etd/1905.

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Successful adoptive immunotherapy (AIT) for cancer relies on the infusion of in vitro expanded, tumor-reactive lymphocytes with a goal of generating productive tumor immunity. Previously, our lab has developed a protocol to activate selectively tumor-reactive T lymphocytes in vitro using two pharmacologic agents, bryostatin-1 and ionomycin. Following the pharmacological stimulation, conventionally, IL-2 is added to stimulate in vitro proliferation. In this report, alternate cytokines from the common cytokine receptor γ-chain family, namely IL-7 and IL-15, were explored as the alternative cytok

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9

Bartolo, Laurent. "Réponses immunitaires et induction de tolérance pour la thérapie génique rAAV du muscle basée sur le ciblage des hépatocytes : induction de tolérance et mécanismes immunitaires liés à la transduction des hépatocytes Liver-based tolerance induction of CD8+ and CD4+ T cells responses in rAAV muscle gene therapy." Thesis, Sorbonne Paris Cité, 2018. http://www.theses.fr/2018USPCB198.

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Les réponses immunes contre les traitements de thérapie génique rAAV, dirigées non seulement contre la capside du vecteur, mais aussi contre le transgène, représentent un défi majeur en particulier dans le contexte d'un transfert de gènes vers le muscle pour le traitement de diverses maladies monogéniques du muscle. Cette thèse est focalisée sur la réponse dirigée contre le transgène. Celle-ci se met en place contre des éléments du transgène thérapeutique qui ne sont pas initialement présents, ou insuffisamment exprimés, chez l'hôte et peut entraîner l'élimination des cellules qui produisent l

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10

El-Sawy, Tarek. "THE MECHANISM AND IMPACT OF EARLY POST-TRANSPLANT INFLAMMATION ON THE ACTIVATION STATE, DOWN-STREAM T LYMPHOCYTE INFILTRATION, AND ESTABLISHMENT OF PROLONGED SURVIVAL OF AN ALLOGRAFT WITH CO-STIMULATION BLOCKADE THERAPY." Connect to online version, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=case1087393648.

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11

Coman, Tereza. "Rôle des lymphocytes NKT invariants humains dans régulation de la réponse alloimmune." Thesis, Université Paris-Saclay (ComUE), 2015. http://www.theses.fr/2015SACLS166.

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La survenue de la maladie du greffon contre l’hôte aiguë (GVHa) après l’allogreffe de cellules souches hématopoïétiques (CSH) reste une source majeure de mortalité et morbidité pour laquelle des avancées thérapeutiques restent indispensables. Les lymphocytes NKT invariants (iNKT) possèdent de multiples propriétés à potentiel immuno-régulateur et anti-tumoral, mais peu de données existent chez l’homme dans le cadre de l’allogreffe de CSH. Nous avons récemment montré qu’une bonne reconstitution en iNKT post greffe ainsi qu’une bonne richesse et capacité d’expansion des iNKT du greffon, notamment

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12

Klysz, Dorota. "Impact of lymphopenia-inducing regimens and energetic resources on the fate of adoptively transferred T cells." Thesis, Montpellier 2, 2014. http://www.theses.fr/2014MON20184/document.

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Les thérapies anti-tumorales se sont considérablement améliorées au cours de la dernière décennie. Toutefois, les traitements utilisés actuellement rencontrent d'importantes limitations, notamment dans le cas de cancers métastatiques, révélant l'urgence de développer de nouvelles approches. Ainsi, l'immunothérapie par transfert adoptif de cellules T représente une approche innovante particulièrement prometteuse. Son principe s'appuie sur l'injection de cellules T autologues spécifiques d'antigènes tumoraux, préalablement manipulées et amplifiées ex vivo, chez des patients rendus lymphopéniques

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Yager, Nicole Leanne. "Natural and therapy-induced immune control of HIV-1." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:e07f3022-4e14-4844-90ac-8d6f52a40a5a.

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The human immunodeficiency virus (HIV)-specific cytotoxic T-lymphocyte (CTL) response is important in the control of HIV-1 infection. Due to the virus having a high rate of mutation, immune pressure can select for variants that are no longer recognised by CTLs to dominate the viral quasispecies. This is similar to how antiretroviral resistance emerges. HIV-1 is therefore adapting to both human leukocyte antigen (HLA)-restricted immune responses and antiretroviral therapy. This thesis initially focused on the natural CTL response to an HLA-B*51-restricted epitope in integrase. This HLA class I

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14

Ralph, Christina. "Modulation of T regulatory activity for cancer therapy." Thesis, University of Manchester, 2011. https://www.research.manchester.ac.uk/portal/en/theses/modulation-of-t-regulatory-activity-for-cancer-therapy(7e39408d-9790-4a0e-9fa2-b6b065f2265e).html.

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Emerging evidence suggests the immune system has a role in preventing cancer, and in advanced cancer evidence of immune dysfunction is widespread. This project focused on cytotoxic T lymphocyte antigen 4 (CTLA4), a key negative regulator of T cell activation found on dedicated regulatory T cells (Treg) and activated T lymphocytes, and asked whether modulation of immune control with anti-CTLA4 blockade led to significant anti-tumour activity. Clinical and laboratory investigation of anti-CTLA4 blockade using tremelimumab in a phase II trial of second-line therapy in advanced oesophageal and gas

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Carretero-Iglesia, Laura. "Autologous regulatory myeloid cell therapy in transplantation." Nantes, 2014. http://archive.bu.univ-nantes.fr/pollux/show.action?id=57eee07a-2290-4c76-b10e-0603a68039b7.

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The aim in organ transplantation is to induce specific long-term allograft tolerance. Current therapies control short-term allograft rejection but are inefficient against late graft failure. Moreover, they carry important side-effects, rendering patients vulnerable to other diseases. New therapies are nowadays being developed. The use of in vitro modified cell types as a strategy to induce donor-specific tolerance has proven to be effective to prolong allograft survival in a variety of animal models. Myeloid cells play a key role in transplantation. They are involved in both, tolerance and rej

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16

Erskine, Ishbel Armour. "Human lymphocytes treated in vivo and in vitro with three drugs : a cytogenetic study." Thesis, University of Aberdeen, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.278354.

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Sister chromatid exchange (SCE) and micronuclei (MN) were studied in peripheral human lymphocytes, treated in vivo with atenolol, azathioprine (AZA) and Chlorpropamide (CPA), and from patients on long term therapy with these drugs. The clinical study consisted of samples from 18 atenolol, 8 AZA and 9 CPA treated patients, and 35 age and sex matched controls. The CPA patients' controls were matched for disease (diabetes). Additional controls monitored variation between culture time. 20 metaphases were scored for SCEs and 2000 cells for MN per person. Statistical comparison of treated and untrea

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17

Bertges, Thaís Abranches Bueno Sabino. "Estudo comparativo dos efeitos do laser de baixa intensidade e do ultrassom terapêutico no reparo tecidual de feridas cirúrgicas cutâneas em ratos Wistar: avaliação histopatológica e produção in situ de mediadores inflamatórios." Universidade Federal de Juiz de Fora, 2015. https://repositorio.ufjf.br/jspui/handle/ufjf/389.

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Submitted by Renata Lopes (renatasil82@gmail.com) on 2016-01-12T13:26:08Z No. of bitstreams: 1 thaisabranchesbuenosabinobertges.pdf: 1644405 bytes, checksum: 3b8373f3de0b6d396b5af331c1897b4a (MD5)<br>Approved for entry into archive by Adriana Oliveira (adriana.oliveira@ufjf.edu.br) on 2016-01-25T17:14:55Z (GMT) No. of bitstreams: 1 thaisabranchesbuenosabinobertges.pdf: 1644405 bytes, checksum: 3b8373f3de0b6d396b5af331c1897b4a (MD5)<br>Made available in DSpace on 2016-01-25T17:14:55Z (GMT). No. of bitstreams: 1 thaisabranchesbuenosabinobertges.pdf: 1644405 bytes, checksum: 3b8373f3de0b6d396

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Yazdanparast, Haniyeh [Verfasser], and Viktor [Akademischer Betreuer] Umansky. "Myeloid cells and therapy resistance in Chronic Lymphocytic Leukemia / Haniyeh Yazdanparast ; Betreuer: Viktor Umansky." Heidelberg : Universitätsbibliothek Heidelberg, 2018. http://d-nb.info/1177385988/34.

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19

Samuel, Sara. "Vesicular stomatitis virus and BCL-2 inhibitor combination therapy for the treatment of chronic lymphocytic leukemia." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=119339.

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Chronic lymphocytic leukemia (CLL) is a cancer of the white blood cells (B cell lymphocytes). It is an indolent disorder that results in the accumulation of CD5+ B cells. In CLL, resistance to cell death is attributed to the overexpression of several key pro-survival proteins (i.e. B-cell lymphoma 2 (Bcl-2) and myeloid cell leukemia- 1 (Mcl-1)) that belong to the apoptotic Bcl-2 family of proteins. Bcl-2 and Mcl-1 overexpression deregulates both the apoptotic and autophagic signaling pathways and contributes to tumorigenesis. Oncolytic virotherapy has emerged as a novel anti-cancer therapy for

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20

Maharry, Kati S. "Risk Factors for Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma Incidence in Postmenopausal Women: a Women’s Health Initiative (WHI) Study." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1460981460.

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21

Marabelle, Aurélien. "Targeting Tumor Specific Regulatory T-cells for Cancer Therapy." Thesis, Lyon, École normale supérieure, 2013. http://www.theses.fr/2013ENSL0832.

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L'activation de TLR9 par injection directe de nucléotides CpG non méthylés dans une tumeur peut induire une réponse immunitaire thérapeutique, mais les lymphocytes T régulateurs (Tregs) inhibent ensuite la réponse immunitaire antitumorale et limitent ainsi le pouvoir des stratégies d'immunothérapies contre le cancer.Chez des souris porteuses de tumeurs, nous avons constaté que les Tregs dans la tumeur expriment préférentiellement les marqueurs cellulaires de surface CTLA-4 et OX40. Nous montrons que la co-injection intratumorale d'anti-CTLA-4 et anti-OX40 avec du CpG en intra-tumoral aboutit à

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22

Imawan, Jensen. "Early and risk adapted therapy with Fludarabine in high risk binet stage a chronic lymphocytic leukemia patients." Diss., lmu, 2009. http://nbn-resolving.de/urn:nbn:de:bvb:19-112034.

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23

Chiodin, Giorgia. "Chronic Lymphocytic Leukemia: analysis of microenvironmental influence on neoplastic clone survival and IgM signaling during Ibrutinib therapy." Doctoral thesis, Università degli studi di Padova, 2017. http://hdl.handle.net/11577/3422771.

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Chronic Lymphocytic Leukemia (CLL) is characterized by the monoclonal expansion of mature CD19+/CD5+/CD23+ B lymphocytes in peripheral blood, bone marrow and lymphoid tissues. Surface IgM (sIgM) signaling is key to CLL behavior and is a therapeutic target of the BTK-inhibitor Ibrutinib. SIgM levels and signaling capacity are variable in CLL and correlate with the behavior of the disease. In CLL, the microenvironment also plays an important role in disease support and progression. In this thesis two projects are presented: the analysis of the microenvironmental influence on neoplastic clone sur

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Honkanen, T. (Tiia). "More efficient use of HER targeting agents in cancer therapy." Doctoral thesis, Oulun yliopisto, 2019. http://urn.fi/urn:isbn:9789526223445.

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Abstract Cancer treatments have remarkably improved over the past years since targeted therapies and immunotherapy have been introduced to the field of oncology. The benefit of these new therapies is often limited, however, by de novo or acquired therapy resistances, which should be noticed when making clinical decisions. In this current work, we studied the prognostic and predictive values of several immunological markers in metastatic HER2-positive breast cancer treated with trastuzumab, because trastuzumab is still given to patients according to the HER2 status only, without certainty of tu

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Bento, Rui Pedro Garcia de Oliveira. "CAR-modified T cells targeted to CD19 antigen for lymphocytic leukemia." Master's thesis, Universidade de Aveiro, 2014. http://hdl.handle.net/10773/13445.

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Mestrado em Biomedicina Farmacêutica<br>Cellular immunotherapies, or Advanced Therapy Medicinal Products (ATMPs), are emerging as novel and specific therapeutic approaches to treat diseases, such as certain types of leukemias, which are difficult or impossible to treat with today’s biopharmaceutical products. Breakthroughs in basic, preclinical, and clinical science spanning cellular immunology, and cellprocessing technologies has allowed clinical applications of chimeric antigen receptor–based therapies. A recent example is CTL019, a lentivirus-based gene therapy for autologous T cells, acqui

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Bôle-Richard, Elodie. "Développement d'outils innovants et sécurisés de thérapie cellulaire et génique basés sur la reprogrammation de lymphocytes T dans un contexte d'immunothérapie anti-tumorale." Thesis, Besançon, 2016. http://www.theses.fr/2016BESA3001/document.

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La thérapie cellulaire est basée sur l'administration de cellules immunocompétentes dans le but d'induire une réponse thérapeutique. Le transfert de gène est un moyen d'optimiser et de sécuriser la thérapie cellulaire. Récemment, plusieurs essais cliniques d'immunothérapie ont montré l'efficacité de lymphocytes T reprogrammés pour le traitement des cancers. De plus, le transfert de gène « suicide » permet de sécuriser les effecteurs immunitaires utilisés en thérapie cellulaire. Cependant, les capacités des cellules pourraient encore être améliorées par l'expression de cytokines et de récepteur

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Crassini, Kyle. "Novel therapies, mRNA expression profiling and immune failure in chronic lymphocytic leukaemia (CLL); applications for in vitro research and clinical management." Thesis, The University of Sydney, 2019. http://hdl.handle.net/2123/21081.

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CLL is the most frequently diagnosed leukaemia in adults. For many patients CLL is a relatively indolent disease, but for those with symptomatic disease treatment may be indicated. In Australia, current front-line therapy most commonly remains chemoimmunotherapy (CIT). However, CLL therapy is in an era of unprecedented change with the development of the targeted therapies such as those discussed in this thesis. Microenvironmental niches have been shown to play a significant role in promoting CLL cell survival and proliferation. Several intracellular signaling pathways are now known to mediat

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Hallböök, Helene. "Acute lymphoblastic leukaemia in adult patients : studies of prognostic factors, treatment results and in vitro cellular drug resistance /." Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5768.

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Carpentier, Maxime. "Modulation des voies de présentation antigénique et induction de lymphocytes T régulateurs pour la thérapie génique." Thesis, Paris 5, 2013. http://www.theses.fr/2013PA05T081.

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L’expression d’un transgène grâce au vecteur AAV offre une perspective thérapeutique très prometteuse dans le traitement de maladies monogéniques. Malheureusement, il apparait souvent que des réponses immunes contre le vecteur et le transgène conduisent à un rejet des cellules transduites ainsi qu’à la mise en place d’une mémoire immunitaire spécifique empêchant un nouveau traitement ultérieur. Avec la perspective d’éviter tout rejet immun des cellules transduites, j’ai développé deux approches distinctes. D’une part, nous avons développé un système dans lequel l’expression du transgène est dé

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Bhatti, Anita [Verfasser]. "Exploring human T lymphocytes expressing a CAR directed to the tumor-neoantigen EGFRvIII for adoptive cellular therapy to non-small cell lung cancer / Anita Bhatti." Mainz : Universitätsbibliothek Mainz, 2019. http://d-nb.info/1179964500/34.

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GUOLO, FABIO. "POST-TRANSPLANT NIVOLUMAB PLUS UNSELECTED AUTOLOGOUS LYMPHOCYTES IN REFRACTORY HODGKIN LYMPHOMA PATIENTS: A SAFE AND EFFECTIVE THERAPY ASSOCIATED WITH EXPANSION AND MATURATION OF NK CELLS." Doctoral thesis, Università degli studi di Genova, 2021. http://hdl.handle.net/11567/1043790.

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Hodgkin Lymphoma (HL) is a B-Cell neoplasia with a favourable outcome in responding patients. However, despite the efficacy of first line therapy about 30% of patients eventually relapse or are refractory (R/R). Recently, the immune checkpoint inhibitor (CI) nivolumab demonstrated good activity in R/R HL patients although the complete response (CR) rate was less than 20%. The efficacy of nivolumab is strictly related to the host degree of immune competence, which is greatly impaired in heavily pre-treated HL patients after autologous stem cell transplantation (ASCT). To enhance the activity of

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Jeanpierre, Lindsay. "Etude des réponses T CD8+ après transfert de gène par rAAV ciblant le muscle." Electronic Thesis or Diss., université Paris-Saclay, 2024. https://www.biblio.univ-evry.fr/theses/2024/interne/2024UPASL128.pdf.

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La thérapie génique par vecteurs dérivés des virus adéno-associés (rAAV), s'est imposée ces dernières décennies, comme une stratégie de traitement innovante, pour le traitement des maladies monogéniques rares. Elle est basée sur l'utilisation d'un vecteur d'origine virale, pour délivrer une séquence d'ADN fonctionnelle, dans les cellules présentant la mutation à l'origine de la maladie.Les avancées dans ce domaine ont conduit à la mise sur le marché de plusieurs produits, dont le ZolgenSMA®, utilisé pour le traitement de l'amyotrophie spinale, qui a permis de soigner plus de 4000 patients dans

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Guipouy, Delphine. "Exploration fonctionnelle de l'activité cytotoxique de lymphocytes T humains en contexte de pathologie et de thérapie." Thesis, Toulouse 3, 2017. http://www.theses.fr/2017TOU30263/document.

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Plusieurs populations de cellules immunitaires possèdent une activité cytotoxique permettant l'élimination de cellules altérées. Cette fonction cellulaire est ainsi déterminante dans le contrôle des infections, des processus tumoraux, ou encore des maladies inflammatoires chroniques. Mon projet de thèse se concentre sur des aspects fondamentaux de l'activité lytique de deux populations de lymphocytes T cytotoxiques : les lymphocytes T CD8+ et les lymphocytes T CD4+ régulateurs de type 1. Pour cela, l'exploration des mécanismes de cette activité a été conduite au travers de deux modèles, pathol

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Mani, Rajeswaran. "Preclinical development of a non-immunosuppressive FTY720 derivative OSU-2S forchronic lymphocytic leukemia and other B-cell malignancies." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1404067069.

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Salazar, Montano Ylia [Verfasser]. "Microenvironmental Th9 and Th17 lymphocytes induce epithelial-mesenchymal transition in lung cancer cells thereby promoting metastatic spreading / Ylia Maria Salazar Montano." Gießen : Universitätsbibliothek, 2020. http://d-nb.info/1223461866/34.

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Salazar, Montano Ylia Maria [Verfasser]. "Microenvironmental Th9 and Th17 lymphocytes induce epithelial-mesenchymal transition in lung cancer cells thereby promoting metastatic spreading / Ylia Maria Salazar Montano." Gießen : Universitätsbibliothek, 2020. http://d-nb.info/1223461866/34.

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Carpenter, Stephen M. "Memory CD8+ T Cell Function during Mycobacterium Tuberculosis Infection: A Dissertation." eScholarship@UMMS, 2016. http://escholarship.umassmed.edu/gsbs_diss/860.

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T cell vaccines against Mycobacterium tuberculosis (Mtb) and other pathogens are based on the principle that memory T cells rapidly generate effector responses upon challenge, leading to pathogen clearance. Despite eliciting a robust memory CD8+ T cell response to the immunodominant Mtb antigen TB10.4 (EsxH), we find the increased frequency of TB10.4-specific CD8+ T cells conferred by vaccination to be short-lived after Mtb challenge. To compare memory and naïve CD8+ T cell function during their response to Mtb, we track their expansions using TB10.4-specific retrogenic CD8+ T cells. We find t

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Júnior, Edilson Diógenes Pinheiro. "Experiência do Serviço de Hematologia do Hospital das Clínicas da FMUSP com leucemia linfóide aguda do adulto: avaliação clínica, laboratorial e dos protocolos de tratamento." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/5/5136/tde-24062008-122745/.

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A leucemia linfóide aguda nos adultos apresenta prognóstico reservado. Os objetivos deste estudo são descrição e análise de parâmetros clínicos, laboratoriais e fatores prognósticos em 102 pacientes tratados com diferentes protocolos de quimioterapia no período de 1990 a 2005, no Serviço de Hematologia do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo. Em estudo de coorte retrospectivo, com exclusão de LLA subtipo L3 (FAB) ou B-IV (EGIL), foram analisadas a taxa de remissão completa (RC), sobrevida global (SG) e sobrevida livre de doença (SLD) para a população gera

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Evangelista, Érika Elisabeth. "Efeito da terapia fotodinâmica na quimiotaxia de macrófagos e linfócitos T ativados no tecido periodontal." Universidade Nove de Julho, 2014. http://bibliotecadigital.uninove.br/handle/tede/1313.

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Submitted by Nadir Basilio (nadirsb@uninove.br) on 2016-05-19T15:16:35Z No. of bitstreams: 1 Erika Elisabeth Evangelista.pdf: 1020129 bytes, checksum: dee500eb8c5a17c94acdc64c0d81e2de (MD5)<br>Made available in DSpace on 2016-05-19T15:16:35Z (GMT). No. of bitstreams: 1 Erika Elisabeth Evangelista.pdf: 1020129 bytes, checksum: dee500eb8c5a17c94acdc64c0d81e2de (MD5) Previous issue date: 2014-12-11<br>Periodontal disease is an inflammatory disease affecting the supporting tissues of the teeth, leading to loss of periodontal ligament and bone. The treatment involves scaling and root planning, an

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Behbahani, Homira. "Immune dysregulation in HIV-1 infected lymphoid tissue /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-193-4.

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Bobisse, Sara. "Ridirezionamento dell'immunità anti-tumorale in terapia cellulare adottiva: trasferimento genico del T-Cell Receptor mediato da vettori lentivirali." Doctoral thesis, Università degli studi di Padova, 2008. http://hdl.handle.net/11577/3425463.

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Genetic modification of T cells with genes encoding a tumor-specific T-cell Receptor (TCR) represents a novel strategy to obtain large quantities of tumor-reactive T lymphocytes to be employed in adoptive cell therapy protocols. As a transfer method, lentiviral vectors might represent an appealing alternative to the most widely used oncoretroviral vectors, because they do not require cell division for nuclear uptake. We have characterized the TCR of a highly cytotoxic T lymphocyte (CTL) clone recognizing the HLA-A2-restricted Melan-A/MART-1 melanocyte differentiation antigen on both pulsed T2

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Gherardi, Léa. "BTLA, une nouvelle cible thérapeutique pour le traitement du lupus ?" Electronic Thesis or Diss., Strasbourg, 2024. http://www.theses.fr/2024STRAJ106.

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Le lupus est une maladie auto-immune caractérisée par la présence d’auto-anticorps. Ces derniers sont produits par des lymphocytes B (LB) différenciés en plasmocytes, et ayant bénéficié de l’aide des lymphocytes T (LT). Le dialogue entre LT et LB est régulé par des récepteurs inhibiteurs comme B and T Lymphocyte Attenuator (BTLA), dont l’expression et la fonction sont altérées chez les patients lupiques. Mon projet de thèse visait à évaluer le potentiel thérapeutique du ciblage de BTLA par un anticorps (Ac) agoniste dans un modèle murin de lupus. Nous avons montré chez les souris NZB/W, partag

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Blaudszun, André-René [Verfasser], and Gerhard [Akademischer Betreuer] Wenz. "Ex vivo activated human T lymphocytes as living drug delivery vehicles for cancer therapy : in vitro studies with nanoparticulate idarubicin and complexed mTHPP as payload / André-René Blaudszun. Betreuer: Gerhard Wenz." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2016. http://d-nb.info/1100061568/34.

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Huang, Kenneth Hsing-Chung. "Immune correlates of viral control in chronic HIV infection." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111908.

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There are currently an estimated 33.2 million people living with human immunodeficiency virus (HIV) worldwide. For these individuals, long-term use of combination antiretroviral therapy (cART) is not feasible for a variety of reasons including major adverse complications, multi-drug resistance, poor adherence, and high cost. Hence, development of novel therapeutic strategies that can reduce the life-long dependency on cART is highly desired. In order to develop effective therapeutic strategies such as a therapeutic vaccine, we need to have a greater understanding of the immune correlates of vi

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Mernick, Ana Paula de Souza. "A terapia fotodinâmica na quimiotaxia de neutrófilos e linfócitos T no tecido periodontal." Universidade Nove de Julho, 2014. http://bibliotecadigital.uninove.br/handle/tede/1312.

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Submitted by Nadir Basilio (nadirsb@uninove.br) on 2016-05-19T15:00:56Z No. of bitstreams: 1 Ana Paula de Souza Mernick.pdf: 747300 bytes, checksum: 7cec9bdaa4c2bd9e6dfcc62d9bfdbd12 (MD5)<br>Made available in DSpace on 2016-05-19T15:00:56Z (GMT). No. of bitstreams: 1 Ana Paula de Souza Mernick.pdf: 747300 bytes, checksum: 7cec9bdaa4c2bd9e6dfcc62d9bfdbd12 (MD5) Previous issue date: 2014-12-16<br>Periodontitis is an infectious disease characterized by the destruction of the supporting tissues of the teeth and therefore the dental loss. Neutrophils are the first cells to arrive in periodontal i

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Sicard, Antoine. "Des antigènes particulaires synthétiques pour manipuler les fonctions anticorpsindépendantes des lymphocytes B : intérêt dans les stratégies d’induction de tolérance allo-immune." Thesis, Lyon, 2016. http://www.theses.fr/2016LYSE1126.

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Dans des modèles expérimentaux, une tolérance d'allogreffe a pu être induite en transférant des lymphocytes T CD4+ régulateurs (Treg) spécifiques d'antigènes (Ag) du donneur expandus ex vivo. Les données ont démontré l'importance des Treg d'allospécificité indirecte (Treg indirects) dans l'induction d'une tolérance à long terme. L'expansion de Treg indirects ex vivo est problématique, principalement à cause de la difficulté d'obtenir en grand nombre des cellules présentatrices d'antigène autologues (CPA)pour stimuler les Treg. Les lymphocytes B (LB) sont des APC accessibles, présentes en grand

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Leclerc, Mathieu. "Modulation de l’effet des lymphocytes T régulateurs par la voie TNFα/TNFR2 : une nouvelle immunothérapie en allogreffe de cellules souches hématopoïétiques". Thesis, Paris Est, 2017. http://www.theses.fr/2017PESC0014/document.

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Les lymphocytes T régulateurs (Treg) jouent un rôle majeur dans la modulation de l’alloréactivité après allogreffe de cellules souches hématopoïétiques et permettent notamment de contrôler la réaction du greffon contre l’hôte (GVH) dans des modèles expérimentaux. Le potentiel thérapeutique des Treg est donc très important dans ce domaine, mais aussi dans l’auto-immunité ou en cancérologie. Cependant, de nombreuses barrières rendent difficile l’élaboration de stratégies thérapeutiques reposant sur le transfert adoptif de Treg chez l’homme et une meilleure compréhension des facteurs et mécanisme

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Tosi, Anna. "Identification of a HLA-A*0201-restricted immunogenic epitope from the universal tumor antigen DEPDC1." Doctoral thesis, Università degli studi di Padova, 2017. http://hdl.handle.net/11577/3424867.

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The identification of universal tumor-specific antigens (TSA) shared between multiple patients and/or multiple tumors is of great importance to overcome the practical limitations of personalized cancer immunotherapy. Recent studies support the involvement of DEPDC1 in many aspects of cancer traits, such as cell proliferation, anti-apoptosis and cell invasion, suggesting that it may play key roles in the oncogenic process. In this study, we report that DEPDC1 expression is up-regulated in several types of human tumors, and closely linked to a poorer prognosis; therefore, it might be regarded as

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CASTELLI, MONICA. "INCREASED SURVIVAL OF CLL B CELLS IN THE PRESENCE OF MARROW MESENCHYMAL STROMAL CELLS: A NOVEL MODEL TO DEFINE NEW TARGETS FOR THERAPY." Doctoral thesis, Università degli studi di Padova, 2016. http://hdl.handle.net/11577/3424459.

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Chronic Lymphocytic Leukemia (CLL) is the most common leukemia in the Western World, accounting for about 30% of adult leukemia, and it is characterized by the clonal expansion and accumulation of mature CD19+/CD5+/CD23+ B lymphocytes in the peripheral blood, bone marrow and secondary lymphoid organs. Despite their apparent longevity in patients, in vitro CLL leukemic B cells rapidly undergo spontaneous apoptosis. The selective survival advantage is due both to intrinsic defects on apoptosis mechanism and to signals delivered by accessory cells at the active site of the disease. Previous studi

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Verfuerth, Stephanie. "In vitro expansion of donor-derived CMV-specific T lymphocytes for adoptive cellular therapy : optimisation of antigen presentation by dendritic cells, characterisation of the culture output, and adaptation of culture conditions to CMV-naïve donors." Thesis, University College London (University of London), 2006. http://discovery.ucl.ac.uk/1445950/.

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Cytomegalovirus infection adversely affects the survival of haemopoietic stem cell transplant recipients, despite antiviral chemotherapy. As an alternative treatment, adoptive cellular therapy can transfer specific immunity from donor to recipient, avoiding drug side effects. A range of methods for the isolation and/or enrichment of CMV-specific donor- derived T cells have been explored. Our cell product comprises donor-derived CMV-specific T cells, enriched through co- culture with CMV antigen-presenting MoDC. These cells are currently assessed in two ongoing clinical studies. To further opti

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