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Dissertations / Theses on the topic 'Lymphocyte'

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1

Culley, Donald A. "Recognition of carbohydrates by T lymphocytes in lymphocyte activation." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape11/PQDD_0022/NQ50137.pdf.

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2

Culley, Donald A. "Recognition of carbohyrates by T lymphocytes in lymphocyte activation." Thesis, McGill University, 1997. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=35686.

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The purpose of this investigation was to elucidate the role of the oligosaccharides of Class II MHC glycoproteins in allostimulation. Plasma membranes (PM) from the Daudi cell line were chemically deglycosylated using anhydrous hydrogen fluoride (HF). Subsequently, native and deglycosylated (dgl) Class II MHC molecules were affinity purified from their respective PM and inserted into the PM of peripheral blood leukocytes (PBL) which were used as stimulators in the mixed leukocyte reaction (MLR). Stimulator and responder cells were from the same donor. Both forms of the antigen were found to el
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3

Bonnefoy-Berard, Nathalie. "Induction et régulation de l'activation des lymphocytes T et B par les globulines antilymphocytaires." Lyon 1, 1992. http://www.theses.fr/1992LYO1H086.

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4

Greenwood, M. R. "B lymphocyte differentiation." Thesis, Imperial College London, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.375109.

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5

Jefferies, W. A. "Lymphocyte surface glycoproteins." Thesis, University of Oxford, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.355757.

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6

McCrea, Anthony Philip. "The role of the T lymphocyte in B cell chronic lymphocytic leukaemia." Thesis, Queen's University Belfast, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.335939.

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7

Moris, Arnaud. "On T lymphocyte alloreactivity." [S.l. : s.n.], 2000. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB8849701.

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8

Bonnefoix, Thierry. "Les lymphocytes T intra-tumoraux dans les lymphomes malins non hodgkiniens B : activation, prolifération et production de facteurs de régulation des cellules B." Grenoble 1, 1991. http://www.theses.fr/1991GRE10153.

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Les lymphocytes t sont constamment presents dans les ganglions envahis par un lymphome malin non hodgkinien b. Ce travail a permis de reunir des arguments en faveur de l'implication de ces cellules t dans le processus tumoral: diminution de la capacite des cellules t a produire de l'interleukine 2 (il2) et a proliferer en presence de pha; pourcentages eleves de cellules t dr+ (activees), et cd4+cd45ra-(memoires), ainsi que de cellules t cd25+ (p55 du recepteur de l'il2); a partir des cellules t cd25+ totales, il a ete obtenu des clones t capables de proliferer au contact des cellules b maligne
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9

Lumbroso, Serge. "Production spontanée in vitro par les lymphocytes circulants d'anticorps spécifiques de Brucella." Montpellier 1, 1990. http://www.theses.fr/1990MON11228.

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10

Barré, Vincent. "La leucemie a grands lymphocytes granuleux : a propos d'un cas ; revue de la litterature." Nice, 1992. http://www.theses.fr/1992NICE6541.

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11

Rigal, Dominique. "Action de l'histamine sur la physiologie des lymphocytes : synthèse bibliographique et apport personnel." Lyon 1, 1987. http://www.theses.fr/1987LYO1H073.

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12

Cox, A. L. "Lymphocyte homeostasis and autoimmunity following therapeutic lymphocyte depletion in the treatment of multiple sclerosis." Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.598102.

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Campath-1H induces immediate lymphocyte depletion and remission of inflammatory disease activity when used to treat multiple sclerosis. A cohort of 16 people with multiple sclerosis were studied for one year following a single pulse of Campath-1H treatment. In addition to reporting on their clinical course, serial detailed immunological investigations were performed focusing on immunoregulation and homeostasis. Two phases of lymphocyte reconstitution following Campath-1H treatment were observed. In the first six months lymphocyte proliferation increased and the residual T cell pool was dominat
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13

Weiss, David M. "Cancer-Specific Stress and Absolute Lymphocyte Count Trajectories in Patients with Chronic Lymphocytic Leukemia." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu147765209495775.

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14

Du, Zhenjian Cheung H. Tak. "Febrile condition and lymphocyte proliferation." Normal, Ill. Illinois State University, 1991. http://wwwlib.umi.com/cr/ilstu/fullcit?p9203029.

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Thesis (Ph. D.)--Illinois State University, 1991.<br>Title from title page screen, viewed December 8, 2005. Dissertation Committee: H. Tak Cheung (chair), Herman E. Brockman, Lynne A. Lucher, Anthony J. Otsuka, Alan J. Katz. Includes bibliographical references (leaves 99-110) and abstract. Also available in print.
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15

Mallett, Susan. "Characterization of T lymphocyte antigens." Thesis, University of Oxford, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.293461.

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16

Carolan, E. J. "Gap junctions in lymphocyte ontogeny." Thesis, University of Glasgow, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.233181.

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17

Bleakey, Jill Susanna. "Evaluating canine T lymphocyte responses." Thesis, University of Liverpool, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.364348.

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18

Edwards, M. R. "Lymphocyte dysfunction and postoperative morbidity." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1420997/.

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Morbidity following major surgery is a growing healthcare problem. Previous studies have shown associations between preoperative lymphopenia and adverse postoperative outcomes, albeit in patient groups with multiple confounding factors. Lymphopenia is also associated with poor outcomes in a range of chronic and acute disease states including cardiac failure and sepsis, where lymphocyte dysfunction and excess lymphocyte apoptosis is observed. Cellular bioenergetic failure has been observed in these disease states and is proposed as a key pathophysiological mediator. The core hypothesis of this
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19

Pereira, Cátia Daniela Isaías. "Lymphocyte populations in Mucopolysaccharidosis patients." Master's thesis, Universidade de Aveiro, 2015. http://hdl.handle.net/10773/15580.

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Mestrado em Biomedicina molecular<br>As doenças de sobrecarga lisossomal (DSLs) constituem um grupo de distúrbios metabólicos raros maioritariamente causados por mutações em hidrolases lisossomais, que conduzem à acumulação anormal de diferentes substratos macromoleculares no interior do lisossoma. Este trabalho é focado nas mucopolissacaridoses (MPSs), um grupo de DSLs resultantes da atividade deficiente de enzimas envolvidas no catabolismo dos glicosaminoglicanos. A MPS II é caraterizada pela perda de atividade da enzima iduronato-2-sulfatase, levando ao armazenamento intralisossomal de sulf
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20

Aucher, Anne. "Étude des caractéristiques de la capture de fragments de membrane par trogocytose par les lymphocytes T et B." Toulouse 3, 2008. http://thesesups.ups-tlse.fr/752/.

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La mise en place des réponses immunitaires a lieu via l'échange de facteurs solubles et la transmission de signaux intracellulaires. Ces dernières années, un nouveau mode de communication a été découvert, mettant en jeu l'échange de fragments de membrane entre cellules en contact. Ce processus, nommé trogocytose, initialement décrit chez les lymphocytes T, est rapide, efficace et présente une spécificité de passage. Mais ses mécanismes et ses rôles physiologiques sont encore mal définis. Mon travail de thèse s'est orienté sur deux axes : mener une étude comparative des mécanismes de la trogocy
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21

Liu, Anquan. "Proinflammatory factor mediated lymphocyte activation - the pivotal role of leukotriene B4 /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-391-7/.

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22

Lemoine, Sébastien. "Étude du rôle du lymphocyte B dans la tolérance périphérique." Brest, 2011. http://www.theses.fr/2011BRES2308.

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Le système immunitaire est équipé de nombreux points de contrôle pour maintenir la tolérance et prévenir l'autoimmunité. Les mécanismes opérant en périphérie sont principalement médiés par les lymphocytes T régulateurs. Dans le contexte de l’autoimmunité, les lymphocytes B sont généralement considérés pathogéniques car produisant des anticorps pouvant causer des dommages aux tissus ciblés. Cependant leur déplétion dans plusieurs modèles murins de maladies autoimmunes induit une pathologie plus sévère, donnant ainsi aux lymphocytes B un rôle régulateur insoupçonné. Des pistes ont été découverte
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23

Denépoux, Stéphane. "Induction de mutations somatiques des gènes d'immunoglobuline dans les lymphocytes B humain in vitro." Lyon 1, 1998. http://www.theses.fr/1998LYO1T045.

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24

Putheti, Prabhakar. "CD4+CD25+ T regulatory cells in multiple sclerosis /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-962-5.

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25

Karlsson, Håkan. "Influence of FK506 on certain aspects of lymphocyte activation and lymphocyte-endothelial cell interactions in vitro." Lund : Dept. of Medical Microbiology, Section of Clinical Immunology, Lund University, 1997. http://catalog.hathitrust.org/api/volumes/oclc/39799195.html.

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26

Han, Shuhua. "β-lymphocyte differentiation in the periphery." Thesis, Imperial College London, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.326157.

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27

Morrow, Michelle Ann. "Identification of genes controlling lymphocyte development." Thesis, University of Cambridge, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.620377.

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28

Watson, Martin Peter. "Lymphocyte costimulation in corneal allograft rejection." Thesis, Imperial College London, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.498610.

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29

McNeil, Christopher John. "Glutamine and lymphocyte metabolism of sheep." Thesis, University of Newcastle Upon Tyne, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.391973.

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30

Van, Wely Catherine Ann. "Cytokines, lymphocyte surface molecules and homing." Thesis, University College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298867.

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31

Matthews, Philip Trystan. "Viral interference with T lymphocyte recognition." Thesis, University of Cambridge, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.621627.

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32

Paterson, Alastair Glen. "Lymphocyte function in human breast cancer." Thesis, University of Edinburgh, 1988. http://hdl.handle.net/1842/20091.

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33

Griffin, Sara L. "Macrophages and lymphocyte responsiveness to mitogen." Thesis, Aston University, 1998. http://publications.aston.ac.uk/12351/.

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Purified B-cells fail to proliferate in response to the strong thymus-independent (TI) antigen Lipopolysaccharide (LPS) in the absence of macrophages (Corbel and Melchers, 1983). The fact that macrophages, or factors derived from them are required is supported by the inability of marginal zone B-cells in infants to respond to highly virulent strains of bacteria such as Neisseria meningitidis and Streptococcus pneumoniae (Timens, 1989). This may be due to the lack of CD21 expression on B-cells in infants which could associate with its co-receptor (C3d) on adjacent macrophages. It is not clear w
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34

Tamang, David L. "Modulation of T lymphocyte cytotoxic potential." abstract and full text PDF (free order & download UNR users only), 2008. http://0-gateway.proquest.com.innopac.library.unr.edu/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3307587.

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35

Van, Reyk David Marc. "Oxidative phenomena in T lymphocyte activation." Thesis, The University of Sydney, 1997. https://hdl.handle.net/2123/27622.

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Murine lymph node cells (LNC) were used as model for the assessment of a role for reactive oxygen species (ROS) in T lymphocyte activation. When 2’7’- dichlorofluorescin (DCFHz) is oxidised it becomes the fluorescent compound dichlorofluorescein. Analysis of DCFHz-loaded LNC by flow cytometry identified an increase in DCFH2 oxidation upon stimulation with a mitogenic dose of the phorbol ester, phorbol myristate acetate. This could also be seen, although to a lesser extent, with a mitogenic dose of the lectin concanavalin A. The phorbol ester-induced increase in DCFH2 oxidation was inhibited
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36

Obino, Dorian. "Molecular mechanisms regulating B lymphocyte polarization." Thesis, Sorbonne Paris Cité, 2016. http://www.theses.fr/2016USPCB031/document.

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Dans les organes lymphoïdes secondaires, les lymphocytes B acquièrent des antigènes immobilisés à la surface de cellules voisines. L’engagement du BCR (récepteur des cellules B) avec de tels antigènes induit la formation d’une synapse immunologique et la polarisation des lymphocytes B. Cette polarisation inclut le repositionnement du centrosome à la synapse immunologique ainsi que le recrutement et la sécrétion locale des lysosomes qui sont nécessaires à l’extraction, l’apprêtement et la présentation des antigènes sur les molécules du complexe majeur d’histocomptabilité de classe II (CMH-II) a
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37

Llory, Jean-François. "Etude structurale et dynamique de la membrane du lymphocyte B dans la leucémie lymphoi͏̈de chronique." Montpellier 1, 1989. http://www.theses.fr/1989MON11288.

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38

Amel, Kashipaz Mohammad Rasoul. "Investigations of cytokine production by lymphocytes and autologous mixed lymphocyte reaction in relation to systemic lupus erythematosus." Thesis, Nottingham Trent University, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.272764.

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39

Gargett, Caroline Eve, and mikewood@deakin edu au. "Studies of the human lymphocyte P2Z receptor and its activation of phospholipase D." Deakin University, 1997. http://tux.lib.deakin.edu.au./adt-VDU/public/adt-VDU20060727.144101.

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Extracellular adenosine 5′-triphosphate (ATP) is an agonist for the P2Z receptor of human leukaemic lymphocytes and opens a Ca <sup>2+</sup>-selective ion channel, which also conducts Ba<sup>2+</sup>, Sr<sup>2+</sup> and the small fluorescent dye, ethidium<sup>+</sup>. A wide range of receptor agonists, many of which raise cytosolic [Ca<sup>2+</sup>] activate phospholipase D (PLD). In the present study, it was shown that both ATP and 3′-O-(4-benzoylbenzoyl)-ATP (BzATP) stimulated PLD activity in a concentration-dependent manner, and the inhibitory effects of suramin, oxidised ATP, extracellula
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40

Rouas-Freiss, Nathalie. "Présentation de l'antigène aux lymphocytes T : influence des phénomènes de capture de l'antigène." Paris 5, 1992. http://www.theses.fr/1992PA05P225.

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41

Mourade, Hélène. "Contribution à l'étude immunologique de l'infection chez le diabétique." Paris 5, 1990. http://www.theses.fr/1990PA05P157.

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42

Bich-Thuy, Lê Thi. "Mécanisme d'action de l'interleukine-2 dans l'activation, la prolifération et la différenciation des lymphocytes humains non activés par des agents exogènes." Lyon 1, 1987. http://www.theses.fr/1987LYO1H070.

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43

DiSanto, James Philip. "Molecular events in human T cell activation : CD4, CD8 and the human Lyt-3 molecules /." Access full-text from WCMC, 1989. http://proquest.umi.com/pqdweb?did=745024391&sid=1&Fmt=2&clientId=8424&RQT=309&VName=PQD.

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44

Debant, Marjolaine. "Etude de la dérégulation des entrées calciques du lymphocyte B de leucémie lymphoïde chronique : mise en évidence d'une nouvelle piste thérapeutique." Thesis, Brest, 2017. http://www.theses.fr/2017BRES0150.

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La leucémie lymphoïde chronique (LLC) constitue l'hémopathie maligne la plus fréquente dans les pays occidentaux et résulte d’une accumulation de lymphocytes B (LB) monoclonaux matures porteurs de la glycoprotéine CD5. Les LB de LLC sont également caractérisées par une altération de l'homéostasie du calcium avec, d'une part, la mise en évidence de facteurs de survie contrôlés par le calcium tels que phospho-ERK, NFAT-2 et IL-10, et d'autre part par une progression de la maladie qui est associée à la réponse au calcium. Tout d'abord, afin de mieux comprendre l'impact de la molécule CD5 sur les
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45

Kwan, Tin-fu. "Lymphocyte development in collagen-induced arthritis mice." Click to view the E-thesis via HKUTO, 2003. http://sunzi.lib.hku.hk/hkuto/record/B31971064.

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46

Krajewski, Andrew Stephen. "Human T-lymphocyte colony formation in vitro." Thesis, University of Edinburgh, 1985. http://hdl.handle.net/1842/24047.

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47

Boon, Adrianus Cornelis Maria. "Cytotoxic T lymphocyte-mediated immunity to influenza." [S.l.] : Rotterdam : [The Author] ; Erasmus University [Host], 2003. http://hdl.handle.net/1765/10473.

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48

Liu, Si. "B lymphocyte function in surgical anergic patients." Thesis, McGill University, 1988. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=64094.

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49

Hercus, Beth Justine. "Modelling T lymphocyte reactions to biomedical materials." Thesis, Queen Mary, University of London, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.423016.

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50

Harper, Catherine. "Studies of cytotoxic T-lymphocyte associated genes." Thesis, Brunel University, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.293103.

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