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Journal articles on the topic 'Lymphocytes T CD4 mémoires'

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Published: 4 June 2021
Last updated: 2 February 2022

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1

Boukhedouni, Nesrine, Clément Jacquemin, Anne-Sophie Darrigade, et al. "Rôle des lymphocytes T effecteurs mémoires CD4+ et CD8+ CXCR3+ dans la perte du mélanocyte au cours du vitiligo." Annales de Dermatologie et de Vénéréologie 143, no. 12 (2016): S423. http://dx.doi.org/10.1016/j.annder.2016.09.059.

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2

Vocanson, M. "Lymphocytes T résidents mémoires dans les eczémas." Annales de Dermatologie et de Vénéréologie 147, no. 11 (2020): A2—A3. http://dx.doi.org/10.1016/j.annder.2020.08.002.

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3

Charerntantanakul, Wasin, and James A. Roth. "Biology of porcine T lymphocytes." Animal Health Research Reviews 7, no. 1-2 (2006): 81–96. http://dx.doi.org/10.1017/s1466252307001235.

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The present review concentrates on the biological aspects of porcine T lymphocytes. Their ontogeny, subpopulations, localization and trafficking, and responses to pathogens are reviewed. The development of porcine T cells begins in the liver during the first trimester of fetal life and continues in the thymus from the second trimester until after birth. Porcine T cells are divided into two lineages, based on their possession of the [@@@]\rmalpha [@@@]β or γδ T-cell receptor. Porcine [@@@]\rmalpha [@@@]β T cells recognize antigens in a major histocompatibility complex (MHC)-restricted manner, w
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4

Mendoza, Luis. "A Virtual Culture of CD4+ T Lymphocytes." Bulletin of Mathematical Biology 75, no. 6 (2013): 1012–29. http://dx.doi.org/10.1007/s11538-013-9814-9.

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5

Siri, Aurélie, Hubert de Boysson, and Guilaine Boursier. "Actualité sur les lymphocytes T régulateurs CD4+." médecine/sciences 28, no. 6-7 (2012): 646–51. http://dx.doi.org/10.1051/medsci/2012286019.

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6

Rudd, Christopher E. "A functional dichotomy in CD4+ T lymphocytes." Immunology Today 9, no. 12 (1988): 367–68. http://dx.doi.org/10.1016/0167-5699(88)91232-7.

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7

Bottomly, Kim. "A functional dichotomy in CD4+ T lymphocytes." Immunology Today 9, no. 9 (1988): 268–74. http://dx.doi.org/10.1016/0167-5699(88)91308-4.

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8

C.P. "Une augmentation de l'expression des cytokines du type Th2 par les lymphocytes T mémoire CD4+ et CD8+ est observée dans le sang, et est associée à une augmentation du taux des IgE sériques totales, mais non à la dermatite atopique." Revue Française d'Allergologie et d'Immunologie Clinique 40, no. 6 (2000): 660. http://dx.doi.org/10.1016/s0335-7457(00)80147-1.

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9

Kaur, Amitinder, Corrina L. Hale, Bradley Noren, Nadine Kassis, Meredith A. Simon, and R. Paul Johnson. "Decreased Frequency of Cytomegalovirus (CMV)-Specific CD4+ T Lymphocytes in Simian Immunodeficiency Virus-Infected Rhesus Macaques: Inverse Relationship with CMV Viremia." Journal of Virology 76, no. 8 (2002): 3646–58. http://dx.doi.org/10.1128/jvi.76.8.3646-3658.2002.

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ABSTRACT The frequency of cytomegalovirus (CMV)-specific CD4+ T lymphocytes was determined in CMV-seropositive rhesus macaques with or without simian immunodeficiency virus (SIV) infection by using the sensitive assays of intracellular cytokine staining and gamma interferon ELISPOT. Both techniques yielded 3- to 1,000-fold-higher frequencies of CMV-specific CD4+ T lymphocytes than traditional proliferative limiting dilution assays. The median frequency of CMV-specific CD4+ T lymphocytes in 23 CMV-seropositive SIV-negative macaques was 0.63% (range, 0.16 to 5.8%). The majority of CMV-specific C
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10

Ryu, Hoon, Chang Duk Jun, Bok Soo Lee, Byung Min Choi, Hyung Min Kim, and Hun-Taeg Chung. "Effect of Qigong Training on Proportions of T Lymphocyte Subsets in Human Peripheral Blood." American Journal of Chinese Medicine 23, no. 01 (1995): 27–36. http://dx.doi.org/10.1142/s0192415x95000055.

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The effect of Qigong training on proportions of T lymphocyte subsets was investigated in human peripheral blood. We observed that the ratio of CD4+/CD8+ T lymphocytes was increased as much as 50% in a trainee group who practiced Qigong training more than 5 months compared to a normal healthy group who did not practice. The absolute number of CD4+ T lymphocytes was also elevated in trainee group with 100 cells/mm 3 more than in normal healthy group. The positive correlation between the ratio of CD4+/CD8+ T lymphocytes and the ratio of CD4+45RA-/CD4+ CD45RA+ T lymphocytes was shown in the traine
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11

Sun, Yue, Sallie R. Permar, Adam P. Buzby, and Norman L. Letvin. "Memory CD4+ T-Lymphocyte Loss and Dysfunction during Primary Simian Immunodeficiency Virus Infection." Journal of Virology 81, no. 15 (2007): 8009–15. http://dx.doi.org/10.1128/jvi.00482-07.

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ABSTRACT It has long been appreciated that CD4+ T lymphocytes are dysfunctional in human immunodeficiency virus (HIV)/simian immunodeficiency virus (SIV)-infected individuals, and it has recently been shown that HIV/SIV infections are associated with a dramatic early destruction of memory CD4+ T lymphocytes. However, the relative contributions of CD4+ T-lymphocyte dysfunction and loss to immune dysregulation during primary HIV/SIV infection have not been fully elucidated. In the current study, we evaluated CD4+ T lymphocytes and their functional repertoire during primary SIVmac251 infection in
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12

Parwata, I. Komang, Endang Retnowati, and Betty Agustina Tambunan. "KOMPLEMEN SERUM C3C DAN LIMFOSIT T-CD4+ DARAH." INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY 19, no. 3 (2016): 197. http://dx.doi.org/10.24293/ijcpml.v19i3.415.

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The incidence of HIV and AIDS infection continues to increase despite various treatments have been applied, thus the mortality rate remains high. The examination of CD4+ T lymphocytes number to determine the immune status and the monitoring of therapy has some limitations in facilities and personnel examination as well as expensive costs. The decrease in CD4+ T lymphocytes number will be followed by an increase in the virus number and complement activation, so that the C3c complement levels will decrease. The purpose of this study was to know the correlation between C3c complement serum levels
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13

Hart, Derek N. J., Min Rao, Xinsheng Ju, and Georgina J. Clark. "Novel Human CD4+ T Lymphocyte Subpopulations Defined by CD300a/c Molecule Expression." Blood 110, no. 11 (2007): 2304. http://dx.doi.org/10.1182/blood.v110.11.2304.2304.

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Abstract CD300a and CD300c are leukocyte membrane glycoproteins encoded by genes in the CD300 complex on human chromosome 17. These molecules function as immunoregulatory molecules that initiate triggering and inhibitory responses following ligation with ligands. The CMRF-35 monoclonal antibody binds to an epitope common to both molecules, expressed on most human leukocyte populations, apart from B lymphocytes and a subpopulation of CD4+ and CD8+ T lymphocytes. We used it to study the distribution of the CD300a and CD300c molecules on peripheral blood CD4+ T lymphocytes and defined novel CD300
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14

Zhao, Dong-Mei, Angela M. Thornton, Richard J. DiPaolo, and Ethan M. Shevach. "Activated CD4+CD25+ T cells selectively kill B lymphocytes." Blood 107, no. 10 (2006): 3925–32. http://dx.doi.org/10.1182/blood-2005-11-4502.

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The suppressive capacity of naturally occurring mouse CD4+CD25+ T cells on T-cell activation has been well documented. The present study is focused on the interaction of CD4+CD25+ T cells and B cells. By coculturing preactivated CD4+CD25+ T cells with B cells in the presence of polyclonal B-cell activators, we found that B-cell proliferation was significantly suppressed. The suppression of B-cell proliferation was due to increased cell death caused by the CD4+CD25+ T cells in a cell-contact–dependent manner. The induction of B-cell death is not mediated by Fas–Fas ligand pathway, but surprisin
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15

Legac, E., B. Autran, H. Merle-Beral, C. Katlama, and P. Debre. "CD4+CD7-CD57+ T cells: a new T-lymphocyte subset expanded during human immunodeficiency virus infection." Blood 79, no. 7 (1992): 1746–53. http://dx.doi.org/10.1182/blood.v79.7.1746.1746.

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Abstract CD7 and CD57 are two cell surface molecules related to the differentiation or functional stages of CD4+ T cells. The CD4+CD7- T cells represent a minor subset of CD4+ cells in normal individuals and are considered to contain the normal counterpart of Sezary T cells; the CD4+CD57+ peripheral blood lymphocytes (PBL) are detectable in long- term renal allograft recipients. We compared the cell surface expression of these CD7 and CD57 markers on CD4+ T lymphocytes in peripheral blood and lymphoid organs from normal individuals and human immunodeficiency virus (HIV)-infected patients. Our
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16

Legac, E., B. Autran, H. Merle-Beral, C. Katlama, and P. Debre. "CD4+CD7-CD57+ T cells: a new T-lymphocyte subset expanded during human immunodeficiency virus infection." Blood 79, no. 7 (1992): 1746–53. http://dx.doi.org/10.1182/blood.v79.7.1746.bloodjournal7971746.

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CD7 and CD57 are two cell surface molecules related to the differentiation or functional stages of CD4+ T cells. The CD4+CD7- T cells represent a minor subset of CD4+ cells in normal individuals and are considered to contain the normal counterpart of Sezary T cells; the CD4+CD57+ peripheral blood lymphocytes (PBL) are detectable in long- term renal allograft recipients. We compared the cell surface expression of these CD7 and CD57 markers on CD4+ T lymphocytes in peripheral blood and lymphoid organs from normal individuals and human immunodeficiency virus (HIV)-infected patients. Our results i
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17

McKay, Paul F., Dan H. Barouch, Jörn E. Schmitz, et al. "Global Dysfunction of CD4 T-Lymphocyte Cytokine Expression in Simian-Human Immunodeficiency Virus/SIV-Infected Monkeys Is Prevented by Vaccination." Journal of Virology 77, no. 8 (2003): 4695–702. http://dx.doi.org/10.1128/jvi.77.8.4695-4702.2003.

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ABSTRACT Human immunodeficiency virus type 1 infection results in a dysfunction of CD4+ T lymphocytes. The intracellular events contributing to that CD4+ T-lymphocyte dysfunction remain incompletely elucidated, and it is unclear whether aspects of that dysfunction can be prevented. The present studies were pursued in a rhesus monkey model of AIDS to explore these issues. Loss of the capacity of peripheral blood CD4+ T lymphocytes to express cytokines was first detected in simian immunodeficiency virus-infected monkeys during the peak of viral replication during primary infection and persisted
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18

Lu, Zhengbin, Lingxian Yuan, Xianzheng Zhou, Eduardo Sotomayor, Hyam I. Levitsky, and Drew M. Pardoll. "Cd40-Independent Pathways of T Cell Help for Priming of Cd8+ Cytotoxic T Lymphocytes." Journal of Experimental Medicine 191, no. 3 (2000): 541–50. http://dx.doi.org/10.1084/jem.191.3.541.

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In many cases, induction of CD8+ CTL responses requires CD4+ T cell help. Recently, it has been shown that a dominant pathway of CD4+ help is via antigen-presenting cell (APC) activation through engagement of CD40 by CD40 ligand on CD4+ T cells. To further study this three cell interaction, we established an in vitro system using dendritic cells (DCs) as APCs and influenza hemagglutinin (HA) class I and II peptide–specific T cell antigen receptor transgenic T cells as cytotoxic T lymphocyte precursors and CD4+ T helper cells, respectively. We found that CD4+ T cells can provide potent help for
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19

Dirix, Violette, Virginie Verscheure, Françoise Vermeulen та ін. "BothCD4+andCD8+Lymphocytes Participate in the IFN-γ Response to Filamentous Hemagglutinin fromBordetella pertussisin Infants, Children, and Adults". Clinical and Developmental Immunology 2012 (2012): 1–9. http://dx.doi.org/10.1155/2012/795958.

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Infant CD4+T-cell responses to bacterial infections or vaccines have been extensively studied, whereas studies on CD8+T-cell responses focused mainly on viral and intracellular parasite infections. Here we investigated CD8+T-cell responses uponBordetella pertussisinfection in infants, children, and adults and pertussis vaccination in infants. Filamentous hemagglutinin-specific IFN-γsecretion by circulating lymphocytes was blocked by anti-MHC-I or -MHC-II antibodies, suggesting that CD4+and CD8+T lymphocytes are involved in IFN-γproduction. Flow cytometry analyses confirmed that both cell types
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20

Poindexter, Nancy J., Michael A. Smith, Arthur E. Haynes, and T. Mohanakumar. "Regulatory function of human CD4+ cytolytic T lymphocytes." Transplant Immunology 7, no. 1 (1999): 45–49. http://dx.doi.org/10.1016/s0966-3274(99)80018-5.

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21

Bainbridge, David R. J., Shirley A. Ellis, and Ian L. Sargent. "HLA-G suppresses proliferation of CD4+ T-lymphocytes." Journal of Reproductive Immunology 48, no. 1 (2000): 17–26. http://dx.doi.org/10.1016/s0165-0378(00)00070-x.

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22

RAJNAVOLGYI, E., and A. LANYI. "Role of CD4 T lymphocytes in antitumor immunity." Advances in Cancer Research 87 (2003): 195–249. http://dx.doi.org/10.1016/s0065-230x(03)87209-3.

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23

Radvany, R. M., L. A. Nonn, M. R. Constanzo-Nordin, and J. Robinson. "Decreased percentages of CD4+ T lymphocytes after photopheresis." Human Immunology 34, no. 1 (1992): 61. http://dx.doi.org/10.1016/0198-8859(92)90227-e.

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24

Mainguy, Anthony, Clara-Eva Paquereau, Paul Stys, and Signe Hässler. "Le microbiote : promoteur de la différenciation des lymphocytes T CD8 mémoires." médecine/sciences 36, no. 6-7 (2020): 659–61. http://dx.doi.org/10.1051/medsci/2020117.

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25

Caldwell, Charles C., Tomohisa Okaya, Andre Martignoni, Thomas Husted, Rebecca Schuster, and Alex B. Lentsch. "Divergent functions of CD4+ T lymphocytes in acute liver inflammation and injury after ischemia-reperfusion." American Journal of Physiology-Gastrointestinal and Liver Physiology 289, no. 5 (2005): G969—G976. http://dx.doi.org/10.1152/ajpgi.00223.2005.

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Hepatic ischemia-reperfusion results in an acute inflammatory response culminating in the recruitment of activated neutrophils that directly injure hepatocytes. Recent evidence suggests that CD4+ lymphocytes may regulate this neutrophil-dependent injury, but the mechanisms by which this occurs remain to be elucidated. In the present study, we sought to determine the type of CD4+ lymphocytes recruited to the liver after ischemia-reperfusion and the manner in which these cells regulated neutrophil recruitment and tissue injury. Wild-type and CD4 knockout (CD4−/−) mice were subjected to hepatic i
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26

Ruan, S., D. R. Samuelson, B. Assouline, M. Morre, and J. E. Shellito. "Treatment with Interleukin-7 Restores Host Defense against Pneumocystis in CD4+T-Lymphocyte-Depleted Mice." Infection and Immunity 84, no. 1 (2015): 108–19. http://dx.doi.org/10.1128/iai.01189-15.

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Pneumocystispneumonia (PCP) is a major cause of morbidity and mortality in patients with HIV infection. CD4+T lymphocytes are critical for host defense against this infection, but in the absence of CD4+T lymphocytes, CD8+T lymphocytes may provide limited host defense. The cytokine interleukin-7 (IL-7) functions to enhance lymphocyte proliferation, survival, and recruitment of immune cells to sites of infection. However, there is little known about the role of IL-7 in PCP or its potential use as an immunotherapeutic agent. We hypothesized that treatment with recombinant human IL-7 (rhIL-7) woul
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27

ENAS S. ESSA, M.D., MAHA A. BASSIOUNY, M. D. ;., and KHALED M. A. EL-ZORKANY, M. D. ;. DOAA M.S. EL-SAYED, M.Sc. "Circulating CD4+ CD28 Null T Cells and CD4+ CD28+ T Lymphocytes in Systemic Lupus Erythematosis." Medical Journal of Cairo University 86, December (2018): 3787–91. http://dx.doi.org/10.21608/mjcu.2018.61495.

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28

Raju, Bindu, Chung F. Tung, Debbie Cheng, et al. "In Situ Activation of Helper T Cells in the Lung." Infection and Immunity 69, no. 8 (2001): 4790–98. http://dx.doi.org/10.1128/iai.69.8.4790-4798.2001.

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ABSTRACT To better understand the lung and systemic responses of helper T cells mediating memory immunity to Mycobacterium tuberculosis, we used three- and four-color flow cytometry to study the surface phenotype of CD4+ lymphocytes. Bronchoalveolar lavage (BAL) fluid and peripheral blood (PB) samples were obtained from a total of 25 subjects, including 10 tuberculosis (TB)-infected subjects, 8 purified-protein-derivative-negative subjects, and 7 purified-protein-derivative-positive subjects. In marked contrast to CD4+ lymphocytes from PB (9% ± 5% expressing CD45RA and CD29), the majority (55%
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29

Imberti, Luisa, Alessandra Sottini, Simona Signorini, Roberto Gorla, and Daniele Primi. "Oligoclonal CD4+CD57+ T-Cell Expansions Contribute to the Imbalanced T-Cell Receptor Repertoire of Rheumatoid Arthritis Patients." Blood 89, no. 8 (1997): 2822–32. http://dx.doi.org/10.1182/blood.v89.8.2822.

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Abstract A peculiar feature of rheumatoid arthritis patients is that they carry clonally expanded CD4+ and CD8+ cells in the peripheral blood. While the distortion of the repertoire of CD8+ cells has been ascribed to the increase of CD8+CD57+ large granular lymphocytes, often detected in these patients, the mechanism responsible for the clonal expansion of CD4+ cells remains unexplained. Here, we report that CD4+CD57+ cells, that in healthy individuals represent a small subset of peripheral CD4+ lymphocytes, are significantly expanded in the peripheral blood of a considerable percentage of rhe
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30

Owen, David L., and Michael A. Farrar. "STAT5 and CD4+ T Cell Immunity." F1000Research 6 (January 11, 2017): 32. http://dx.doi.org/10.12688/f1000research.9838.1.

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STAT5 plays a critical role in the development and function of many cell types. Here, we review the role of STAT5 in the development of T lymphocytes in the thymus and its subsequent role in the differentiation of distinct CD4+ helper and regulatory T-cell subsets.
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31

Inaba, K., J. W. Young, and R. M. Steinman. "Direct activation of CD8+ cytotoxic T lymphocytes by dendritic cells." Journal of Experimental Medicine 166, no. 1 (1987): 182–94. http://dx.doi.org/10.1084/jem.166.1.182.

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Recent experiments (11-13) have shown that antigen-specific, CD8+, CD4- T lymphocytes can be induced to proliferate and become killer cells in the absence of a second population of "helper" CD8-, CD4+ cells. We have studied early events in the activation of CD4+ and CD8+ T cell subsets in the primary mixed leukocyte reaction. Dendritic cells are a major if not essential accessory cell for the activation of both subpopulations. Antigen-bearing macrophages fail to stimulate unprimed CD8+ cells, but act as targets for the sensitized cytolytic lymphocytes that are induced by dendritic cells. The i
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32

Jiménez-Martínez, María C., Ricardo Lascurain, Aniela Méndez-Reguera, et al. "O-Glycosylation of NnTreg Lymphocytes Recognized by theAmaranthus leucocarpusLectin." Clinical and Developmental Immunology 2013 (2013): 1–9. http://dx.doi.org/10.1155/2013/506807.

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O-glycosidically-linked glycans have been involved in development, maturation, homing, and immune regulation in T cells. Previous reports indicate thatAmaranthus leucocarpuslectin(ALL), specific for glycans containing galactose-N-acetylgalactosamine and N-acetylgalactosamine, recognizes human naïve CD27+CD25+CD4+T cells. Our aim was to evaluate the phenotype of CD4+T cells recognized byALLin peripheral blood mononuclear cells obtained from healthy volunteers. CD4+T cells were isolated by negative selection using magnetic beads-labeled monoclonal antibodies; the expression of T regulatory cell
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33

Wang, Zhigang, Guanghua Luo, Yuehua Feng, et al. "Decreased SplenicCD4+T-Lymphocytes in Apolipoprotein M Gene Deficient Mice." BioMed Research International 2015 (2015): 1–8. http://dx.doi.org/10.1155/2015/293512.

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Spleen T-lymphocytes, especially CD4+T-cells, have been demonstrated to be involved in broad immunomodulation and host-defense activity in vivo. Apolipoprotein M gene (apoM) may have an important role in the regulation of immunoprocess and inflammation, which could be hypothesized to the apoM containing sphingosine-1-phosphate (S1P). In the present study we demonstrate that the splenic CD4+T-lymphocytes were obviously decreased in the apoM gene deficient (apoM−/−) mice compared to the wild type (apoM+/+). Moreover, these mice were treated with lipopolysaccharide (LPS) and it was found that eve
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34

Jung, Jae Wook, Jin Hong Chun, Jung Seok Lee, et al. "Characterization of CD4-Positive Lymphocytes in the Antiviral Response of Olive Flounder (Paralichthys oliveceus) to Nervous Necrosis Virus." International Journal of Molecular Sciences 21, no. 11 (2020): 4180. http://dx.doi.org/10.3390/ijms21114180.

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The presence of CD4 T lymphocytes has been described for several teleost species, while many of the main T cell subsets have not been characterized at a cellular level, because of a lack of suitable tools for their identification, e.g., monoclonal antibodies (mAbs) against cell markers. We previously described the tissue distribution and immune response related to CD3ε and CD4-1 T cells in olive flounder (Paralichthys oliveceus) in response to a viral infection. In the present study, we successfully produce an mAb against CD4-2 T lymphocytes from olive flounder and confirmed its specificity us
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35

Zhou, Qinjie, Diego F. Niño, Yukihiro Yamaguchi, et al. "Necrotizing enterocolitis induces T lymphocyte–mediated injury in the developing mammalian brain." Science Translational Medicine 13, no. 575 (2021): eaay6621. http://dx.doi.org/10.1126/scitranslmed.aay6621.

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Necrotizing enterocolitis (NEC) causes acute intestinal necrosis in premature infants and is associated with severe neurological impairment. In NEC, Toll-like receptor 4 is activated in the intestinal epithelium, and NEC-associated brain injury is characterized by microglial activation and white matter loss through mechanisms that remain unclear. We now show that the brains of mice and humans with NEC contained CD4+ T lymphocytes that were required for the development of brain injury. Inhibition of T lymphocyte influx into the brains of neonatal mice with NEC reduced inflammation and prevented
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36

Bagot, Martine, Hamid Echchakir, Fathia Mami-Chouaib, et al. "Isolation of Tumor-Specific Cytotoxic CD4+ and CD4+CD8dim+ T-Cell Clones Infiltrating a Cutaneous T-Cell Lymphoma." Blood 91, no. 11 (1998): 4331–41. http://dx.doi.org/10.1182/blood.v91.11.4331.

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Abstract We have isolated several T-cell clones from lymphocytes infiltrating a human major histocompatibility class (MHC) II negative cutaneous T-cell lymphoma (CTCL). We describe here two of these clones, TC5 and TC7, with, respectively, a CD4+CD8dim+ and CD4+CD8− phenotype. Both clones mediated a specific MHC class I–restricted cytotoxic activity toward the fresh autologous tumor cells, and autologous tumor cell lines previously established with interleukin-2 (IL-2) and IL-7 from the skin and from the blood. Analysis of the T-cell receptor (TCR) Vβ gene expression showed that the tumor cell
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37

Bagot, Martine, Hamid Echchakir, Fathia Mami-Chouaib, et al. "Isolation of Tumor-Specific Cytotoxic CD4+ and CD4+CD8dim+ T-Cell Clones Infiltrating a Cutaneous T-Cell Lymphoma." Blood 91, no. 11 (1998): 4331–41. http://dx.doi.org/10.1182/blood.v91.11.4331.411k12_4331_4341.

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We have isolated several T-cell clones from lymphocytes infiltrating a human major histocompatibility class (MHC) II negative cutaneous T-cell lymphoma (CTCL). We describe here two of these clones, TC5 and TC7, with, respectively, a CD4+CD8dim+ and CD4+CD8− phenotype. Both clones mediated a specific MHC class I–restricted cytotoxic activity toward the fresh autologous tumor cells, and autologous tumor cell lines previously established with interleukin-2 (IL-2) and IL-7 from the skin and from the blood. Analysis of the T-cell receptor (TCR) Vβ gene expression showed that the tumor cells, which
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38

Sardella, G., L. De Luca, V. Francavilla та ін. "Effect of Coronary Percutaneous Revascularization on Interferon-γ and Interleukin-10 Producing CD4+ T Cells during Acute Myocardial Infarction". International Journal of Immunopathology and Pharmacology 20, № 4 (2007): 791–99. http://dx.doi.org/10.1177/039463200702000415.

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T lymphocytes play an important role in the induction and progression of acute coronary syndromes (ACS). To gain insight into how different T cell subsets can influence ACS, we analyzed the frequencies of circulating CD4+T cells producing either pro-inflammatory interferon(IFN)-γ or anti-inflammatory interleukin (IL)-10 in subjects presenting with ST-elevation myocardial infarction (STEMI). The effect of coronary bare metal (BS) and paclitaxel-eluting stent (PES) on the balance between CD4+IFN-γ+ and CD4+IL-10+ lymphocytes was also investigated. Peripheral blood mononuclear cells (PBMC) were i
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39

Gize, Addisu, Biniam Mathewos, Beyene Moges, Meseret Workineh, and Lealem Gedefaw. "Establishment of Normal Reference Intervals for CD3+, CD4+, CD8+, and CD4+to CD8+Ratio of T Lymphocytes in HIV Negative Adults from University of Gondar Hospital, North West Ethiopia." AIDS Research and Treatment 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/267450.

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Background.Reference values for the CD3+, CD4+, CD8+, and CD4+to CD8+ratio T lymphocyte subsets are adopted from textbooks. But for appropriate diagnosis, treatment, and follow-up of patients, correct interpretations of the laboratory results from normal reference interval are mandatory. This study was, therefore, planned to establish normal reference interval for T lymphocytes subset count and CD4+to CD8+ratio.Methods.A cross-sectional study was conducted on apparently healthy adult individuals who visited voluntary counseling and HIV testing clinic Gondar University Hospital from April to Ma
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Saidakova, E. V. "ROLE OF DISTINCT CD4+ T-CELL SUBSETS IN HIV-INFECTION PATHOGENESIS." Вестник Пермского университета. Серия «Биология»=Bulletin of Perm University. Biology, no. 3 (2020): 236–46. http://dx.doi.org/10.17072/1994-9952-2020-3-236-246.

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CD4+ T-cell pool is composed of cells residing in different maturation stages. Naive CD4+ T-lymphocytes, CD4+ stem memory T-cells, CD4+ central and effector memory T-lymphocytes perform var-ious functions in maintaining the immune system homeostasis. Despite phenotypic differences, each of those cells can be infected with HIV. Specific features of distinct CD4+ T-lymphocyte subsets determine their role in HIV-infection pathogenesis. By analyzing changes of CD4+ T-lymphocyte subset composi-tion, one can estimate the degree of the immune system damage and make predictions of immune recov-ery und
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Shankar, Premlata, Zhan Xu, and Judy Lieberman. "Viral-Specific Cytotoxic T Lymphocytes Lyse Human Immunodeficiency Virus–Infected Primary T Lymphocytes by the Granule Exocytosis Pathway." Blood 94, no. 9 (1999): 3084–93. http://dx.doi.org/10.1182/blood.v94.9.3084.

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Abstract Cytotoxic T lymphocytes (CTL) lyse antigen-bearing target cells by two distinct pathways. Whereas granule exocytosis targets any antigen-bearing cell, fas-mediated cytotoxicity kills only fas-expressing cells and does not require antigen expression. Fas pathway activation can potentially lead to lysis of uninfected bystander cells. We examined the relative usage of the two pathways by CTL clones and cell lines directed against four different human immunodeficiency virus (HIV) proteins in lysing primary HIV-infected targets. Although fas was expressed on HIV-infected primary CD4+ T cel
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Shankar, Premlata, Zhan Xu, and Judy Lieberman. "Viral-Specific Cytotoxic T Lymphocytes Lyse Human Immunodeficiency Virus–Infected Primary T Lymphocytes by the Granule Exocytosis Pathway." Blood 94, no. 9 (1999): 3084–93. http://dx.doi.org/10.1182/blood.v94.9.3084.421k02_3084_3093.

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Cytotoxic T lymphocytes (CTL) lyse antigen-bearing target cells by two distinct pathways. Whereas granule exocytosis targets any antigen-bearing cell, fas-mediated cytotoxicity kills only fas-expressing cells and does not require antigen expression. Fas pathway activation can potentially lead to lysis of uninfected bystander cells. We examined the relative usage of the two pathways by CTL clones and cell lines directed against four different human immunodeficiency virus (HIV) proteins in lysing primary HIV-infected targets. Although fas was expressed on HIV-infected primary CD4+ T cells, their
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43

Jung, Jae Wook, Ae Rin Lee, Jaesung Kim, et al. "Elucidating the Functional Roles of Helper and Cytotoxic T Cells in the Cell-Mediated Immune Responses of Olive Flounder (Paralichthys olivaceus)." International Journal of Molecular Sciences 22, no. 2 (2021): 847. http://dx.doi.org/10.3390/ijms22020847.

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In higher vertebrates, helper and cytotoxic T cells, referred to as CD4 and CD8 T lymphocytes, respectively, are mainly associated with adaptive immunity. The adaptive immune system in teleosts involves T cells equivalent to those found in mammals. We previously generated monoclonal antibodies (mAbs) against olive flounder (Paralichthys olivaceus) CD4 T cells, CD4-1 and CD4-2, and used these to describe the olive flounder’s CD4 Tcell response during a viral infection. In the present study, we successfully produced mAbs against CD8 T lymphocytes and their specificities were confirmed using immu
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Sardinha, Luiz Roberto, Rosa Maria Elias, Tainá Mosca та ін. "Contribution of NK, NK T, γδ T, and αβ T Cells to the Gamma Interferon Response Required for Liver Protection against Trypanosoma cruzi". Infection and Immunity 74, № 4 (2006): 2031–42. http://dx.doi.org/10.1128/iai.74.4.2031-2042.2006.

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ABSTRACT In the present work, we show that intracellular Trypanosoma cruzi is rarely found in the livers of acutely infected mice, but inflammation is commonly observed. The presence of numerous intrahepatic amastigotes in infected gamma interferon (IFN-γ)-deficient mice corroborates the notion that the liver is protected by an efficient local immunity. The contribution of different cell populations was suggested by data showing that CD4- and CD8-deficient mice were able to restrain liver parasite growth. Therefore, we have characterized the liver-infiltrating lymphocytes and determined the so
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Zheng, Jiayu, Wenshuo Wang, Tao Hong, Shouguo Yang, Jinqiang Shen, and Chen Liu. "Suppression of microRNA-155 exerts an anti-inflammatory effect on CD4+ T cell-mediated inflammatory response in the pathogenesis of atherosclerosis." Acta Biochimica et Biophysica Sinica 52, no. 6 (2020): 654–64. http://dx.doi.org/10.1093/abbs/gmaa040.

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Abstract In the current study, we aimed to investigate the effects of miR-155 on CD4+ T cell-mediated immune response in the pathogenesis of atherosclerosis. CD34+ hematopoietic stem cells, CD4+ T lymphocytes, endothelial cells (ECs), and vascular smooth muscle cells (VSMCs) were harvested from the same donor. Knockdown of miR-155 in the CD4+ T cells was achieved by lentiviral transfection, whereas control RNA-transfected or untransfected lymphocytes were used as controls. The transfected CD4+ T cells were activated by incubating with oxidized low-density lipoprotein-treated dendritic cells. T
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Herbein, Georges, Carine Van Lint, Jennie L. Lovett, and Eric Verdin. "Distinct Mechanisms Trigger Apoptosis in Human Immunodeficiency Virus Type 1-Infected and in Uninfected Bystander T Lymphocytes." Journal of Virology 72, no. 1 (1998): 660–70. http://dx.doi.org/10.1128/jvi.72.1.660-670.1998.

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ABSTRACT Apoptosis is a main feature of AIDS pathogenesis and is thought to play a role in the progressive decrease of CD4+ T lymphocytes in infected individuals. To determine whether apoptosis occurs in infected and/or in uninfected peripheral blood T lymphocytes, we have used a recombinant human immunodeficiency virus type 1 (HIV-1) infectious clone expressing the green fluorescent protein (GFP). Using flow cytometry, we have determined the incidence of apoptosis by either terminal transferase dUTP nick end labeling or annexin-V assays in different cell subpopulations, i.e., in CD4+ or CD8+
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Li, Sicheng, Yichen Huang, Yang Liu, et al. "Change and predictive ability of circulating immunoregulatory lymphocytes in long-term outcomes of acute ischemic stroke." Journal of Cerebral Blood Flow & Metabolism 41, no. 9 (2021): 2280–94. http://dx.doi.org/10.1177/0271678x21995694.

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Lymphocytes play an important role in the immune response after stroke. However, our knowledge of the circulating lymphocytes in ischemic stroke is limited. Herein, we collected the blood samples of clinical ischemic stroke patients to detect the change of lymphocytes from admission to 3 months after ischemic stroke by flow cytometry. A total of 87 healthy controls and 210 patients were enrolled, and the percentages of circulating T cells, CD4+ T cells, CD8+ T cells, double negative T cells (DNTs), CD4+ regulatory T cells (Tregs), CD8+ Tregs, B cells and regulatory B cells (Bregs) were measure
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Skendros, Panagiotis, Alexandros Sarantopoulos, Konstantinos Tselios, and Panagiota Boura. "Chronic Brucellosis Patients Retain Low Frequency of CD4+ T-Lymphocytes Expressing CD25 and CD28 afterEscherichia coliLPS Stimulation of PHA-Cultured PBMCs." Clinical and Developmental Immunology 2008 (2008): 1–8. http://dx.doi.org/10.1155/2008/327346.

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Chronic brucellosis patients display a defective Th1 response to PHA. We have previously shown that heat-killed B. abortus (HKBA) can downregulate the PHA-induced increase of CD4+/CD25+ and CD14+/CD80+ cells of brucellosis patients. In the present study, we investigate the effect ofE. coliLPS, as a potent stimulant of monocytes and autologous T-lymphocytes, on the PHA-cultured PBMCs of the same groups of patients. Thirteen acute brucellosis (AB) patients, 22 chronic brucellosis (CB) patients, 11 “cured” subjects, and 15 healthy volunteers were studied. The percentage of CD4+/CD25+ and CD4+/CD2
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Badley, Andrew D., David Dockrell, Margaret Simpson, et al. "Macrophage-dependent Apoptosis of CD4+ T Lymphocytes from HIV-infected Individuals Is Mediated by FasL and Tumor Necrosis Factor." Journal of Experimental Medicine 185, no. 1 (1997): 55–64. http://dx.doi.org/10.1084/jem.185.1.55.

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Apoptosis of bystander uninfected CD4+ T lymphocytes by neighboring HIV-infected cells is observed in cell culture and in lymphoid tissue of HIV-infected individuals. This study addresses whether antigen-presenting cells such as human macrophages mediate apoptosis of CD4+ T cells from HIV-infected individuals. Uninfected human macrophages, and to a larger degree, HIV-infected macrophages mediate apoptosis of T cells from HIV-infected, but not from uninfected control individuals. This macrophage-dependent killing targets CD4+, but not CD8+ T lymphocytes from HIV-infected individuals, and direct
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Shichishima, Akiko, Hideyoshi Noji, Kazuhiko Ikeda, Yukio Maruyama та Tsutomu Shichishima. "High Frequencies of Increased Interferon-γ-Producing and/or Skewed CD8+ T Lymphocyte Subfamilies in Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH)." Blood 108, № 11 (2006): 980. http://dx.doi.org/10.1182/blood.v108.11.980.980.

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Abstract Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal hematological disorder affecting all hematopoietic lineages, which lack glycosylphosphatidylinositol (GPI)-anchored membrane proteins due to somatic mutations in the phosphatidylinositol glycan-class A gene, and is one disorder of bone marrow failure (BMF) syndromes. Autoreactive T lymphocytes are implicated in some of the immune mechanisms involved in PNH. In fact, we reported recently that the HLA-DRB1*1501 allele and HLA-A*0206 allele is frequent and is related to grading of hemolysis, respectively, in PNH patients (Sh
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