Academic literature on the topic 'Lymphocytes T [LT]'

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Journal articles on the topic "Lymphocytes T [LT]"

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Chen, Lin-Ying, Julia Y. S. Tsang, Yun-Bi Ni, et al. "Lymphocyte subsets contribute to the degree of lobulitis and ductitis in sclerosing lymphocytic lobulitis of the breast." Journal of Clinical Pathology 69, no. 6 (2015): 527–32. http://dx.doi.org/10.1136/jclinpath-2015-203334.

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AimsSclerosing lymphocytic lobulitis (SLL) of the breast is characterised by lymphocytic lobulitis, ductitis, vasculitis and dense keloidal fibrosis with epithelioid fibroblasts. However, the subsets of the infiltrating lymphocytes and their contribution to disease progression have not been fully explored.MethodsCD20, CD3, CD4, CD8 and regulatory T (Treg) lymphocytes were evaluated in the epithelial and vascular areas in SLL. The relationship between the lymphocyte subset in different regions and the degree of inflammation was analysed.ResultsLymphocytic infiltration was mainly located in peri
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Park, Suk W., Walter Royal, Richard D. Semba, Gordon W. Wiegand, and Diane E. Griffin. "Expression of Adhesion Molecules and CD28 on T Lymphocytes during Human Immunodeficiency Virus Infection." Clinical Diagnostic Laboratory Immunology 5, no. 4 (1998): 583–87. http://dx.doi.org/10.1128/cdli.5.4.583-587.1998.

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ABSTRACT Adhesion molecules, which play a major role in lymphocyte circulation, have not been well characterized in human immunodeficiency virus (HIV) infection. T-lymphocyte populations, including CD3, CD4, CD28, and adhesion molecules (L selectin, LFA-1, VLA-4, and ICAM-1) were measured by flow cytometry in a cross-sectional study of 100 HIV-infected and 49 HIV-seronegative adults. HIV-infected adults had lower numbers of CD3+ lymphocytes expressing L selectin (P < 0.0001) and VLA-4 (P < 0.01) and higher numbers of CD3+ lymphocytes expressing LFA-1bright (P < 0.002) than did HIV-neg
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Chen, Yang, Yanyan Xie, Min Ruan та Jinning Shi. "The Levels of T Lymphocyte Subsets in Immune Thrombocytopenia Associated with Anti-GPIIb/IIIa- and/or Anti-GPIbα-Mediated Responses Are Differentially Sensitive to Dexamethasone". Acta Haematologica 140, № 1 (2018): 60–66. http://dx.doi.org/10.1159/000491977.

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Objective: The aim of this work was to investigate the influence of T lymphocyte subsets and platelet-specific autoantibodies on immune thrombocytopenia (ITP) with dexamethasone therapy. Methods: The samples were obtained from patients before therapy. T lymphocyte subsets were measured by flow cytometry, and platelet-specific autoantibodies were evaluated by modified monoclonal antibody immobilization of platelet antigen assay. Results: A total of 50 ITP patients were involved in the study. Twenty-three were anti-GPIbα antibody positive and were treated with dexamethasone, with a response rate
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Morice, William G., Paul J. Kurtin, Ayalew Tefferi, and Curtis A. Hanson. "Distinct bone marrow findings in T-cell granular lymphocytic leukemia revealed by paraffin section immunoperoxidase stains for CD8, TIA-1, and granzyme B." Blood 99, no. 1 (2002): 268–74. http://dx.doi.org/10.1182/blood.v99.1.268.

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Unlike other leukemia types in which the bone marrow findings are diagnostic, the bone marrow pathology of T-cell granular lymphocytic leukemia (GLL) is subtle and ill-defined. In this study, bone marrow biopsy specimens from 36 patients with T-cell GLL and from 25 control patients with cytopenias and relative or absolute increases in blood large granular lymphocytes were studied by immunohistochemistry using antibodies to the cytolytic lymphocyte antigens CD8, CD56, CD57, TIA-1, and granzyme B. The goals were to clarify the bone marrow pathology of T-cell GLL and to refine the diagnostic crit
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Kopecký, Otakar, Šárka Lukešová, Vladimíra Vroblová, et al. "Phenotype Analysis of Tumour-infiltrating Lymphocytes and Lymphocytes in Peripheral Blood in Patients with Renal Carcinoma." Acta Medica (Hradec Kralove, Czech Republic) 50, no. 3 (2007): 207–12. http://dx.doi.org/10.14712/18059694.2017.84.

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Introduction: When checking tumour growth, a number of observations indicate that the immune system plays a significant role in patients with renal cell carcinoma (RCC). Infiltration by lymphocytes (tumour infiltrating lymphocytes, TILs) is more prevalent in RCC than any other tumours. T lymphocytes are the dominant population of TIL cells. Views concerning the role of T lymphocytic subpopulations, B lymphocytes and NK cells in an anti-tumour response are not established. Aim: The aim is to determine the phenotype and activation of T and B lymphocytic subpopulations and NK cells and to compare
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Qiang, Wu, Lu Chunxiao, Wu Jiafeng, et al. "Association of T lymphocytes level and clinical severity in patients of COVID-19 in Shenzhen China." European Journal of Inflammation 19 (January 2021): 205873922110144. http://dx.doi.org/10.1177/20587392211014409.

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To explore the correlation between T lymphocytes and clinical severity in patients of COVID-19. A total of 183 COVID-19 patients were recruited in Shenzhen Third People’s Hospital from January 11 to February 16, 2020. According to the clinical classification criteria, they were divided into severe group (46 cases) and non-severe (137cases). T lymphocyte counts, lymphocyte subpopulation, IL-6 levels, and clinical outcomes were compared between the two groups. Compared with the non-severe group, the lymphocyte count, T lymphocyte count, T lymphocyte percentage, CD4+ T lymphocyte count, CD4+ T ly
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Lancaster, G. I., Q. Khan, P. T. Drysdale, et al. "Effect of prolonged exercise and carbohydrate ingestion on type 1 and type 2 T lymphocyte distribution and intracellular cytokine production in humans." Journal of Applied Physiology 98, no. 2 (2005): 565–71. http://dx.doi.org/10.1152/japplphysiol.00754.2004.

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The present study was undertaken to examine the role of the exercise-induced stress hormone response on the regulation of type 1 and type 2 T lymphocyte intracellular cytokine production. Subjects performed 2.5 h of cycling exercise at 65% maximal O2 uptake while ingesting a 6.4% carbohydrate (CHO) solution, 12.8% CHO solution, or a placebo. Peripheral whole blood samples were stimulated and stained for T lymphocyte surface antigens (CD4 and CD8). Cells were then permeabilized, stained for intracellular cytokines, and analyzed using flow cytometry. Exercise resulted in a decrease ( P < 0.05
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Shi, Chenyuan, Chaoqun Hou, Xiaole Zhu, et al. "New Predictor of Organ Failure in Acute Pancreatitis: CD4+ T Lymphocytes and CD19+ B Lymphocytes." BioMed Research International 2018 (December 5, 2018): 1–8. http://dx.doi.org/10.1155/2018/1012584.

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Objective. Lymphocytes are one of the main effector cells in the inflammatory response of acute pancreatitis (AP). The purpose of the study was to evaluate whether peripheral blood lymphocyte (PBL) subsets at admission change during AP based on clinical outcomes and to explore whether these changes vary by aetiology of AP. Hence, we performed a prospective study to find a predictor in lymphocyte subsets that might allow easier, earlier, and more accurate prediction of clinical outcomes. Methods. Patients with AP were enrolled from December 2017 to June 2018 at the First Affiliated Hospital of
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Kaur, Amitinder, Michele Di Mascio, Amy Barabasz, et al. "Dynamics of T- and B-Lymphocyte Turnover in a Natural Host of Simian Immunodeficiency Virus." Journal of Virology 82, no. 3 (2007): 1084–93. http://dx.doi.org/10.1128/jvi.02197-07.

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ABSTRACT Increased lymphocyte turnover is a hallmark of pathogenic lentiviral infection. To investigate perturbations in lymphocyte dynamics in natural hosts with nonpathogenic simian immunodeficiency virus (SIV) infection, the nucleoside analog bromodeoxyuridine (BrdU) was administered to six naturally SIV-infected and five SIV-negative sooty mangabeys. As a measure of lymphocyte turnover, we estimated the mean death rate by fitting a mathematical model to the fraction of BrdU-labeled cells during a 2-week labeling and a median 10-week delabeling period. Despite significantly lower total T- a
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Simpson, Richard J., Geraint D. Florida-James, Cormac Cosgrove, et al. "High-intensity exercise elicits the mobilization of senescent T lymphocytes into the peripheral blood compartment in human subjects." Journal of Applied Physiology 103, no. 1 (2007): 396–401. http://dx.doi.org/10.1152/japplphysiol.00007.2007.

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Clonal expansion of T lymphocytes in response to antigenic stimulation is a fundamental process of adaptive immunity. As a consequence of clonal expansion, some T lymphocytes acquire a senescent phenotype, fail to replicate in response to further antigenic stimulation, and express the killer cell lectin-like receptor G1 (KLRG1) and/or CD57. Physical exercise elicits a mobilization of large numbers of T lymphocytes into the bloodstream from peripheral lymphoid compartments, but the frequency of senescent cells in the mobilized population is not known. Eight male runners (age: 29 ± 9 yr; maximal
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Dissertations / Theses on the topic "Lymphocytes T [LT]"

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Rossignol, Julien. "Rôle de la Neuropiline dans la réponse immunitaire antitumorale des Lymphocytes T CD8+." Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS440.

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La compréhension récente des mécanismes impliqués dans l’échappement tumoral au système immunitaire est fondamentale. En effet, cela a permis le développement de nouvelles immunothérapies à l’origine de réponses prolongées chez les patients atteints par plusieurs types de cancers. Cependant, une majorité de patients répondent insuffisamment ou rechutent. Il est donc indispensable d’identifier les mécanismes de résistances aux immunothérapies, et de nouvelles cibles permettant d’augmenter l’activité de ces thérapeutiques.La Neuropiline-1 (Nrp1) est une glycoprotéine transmembranaire indispensab
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Milpied, Pierre. "Expression de la neuropiline-1 dans les lymphocytes T conventionnels et << invariant natural killer T >> (iNKT) mutins." Paris 11, 2010. http://www.theses.fr/2010PA11T067.

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Peguillet, Isabelle. "Lymphocytes T CD4 et immunité anti-tumorale naturelle : impact de la chimiothérapie, émergence de lymphocytes T CD4 cytotoxiques." Thesis, Paris 5, 2014. http://www.theses.fr/2014PA05T034/document.

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Historiquement, les LT CD8 cytotoxiques ont été considérés comme la seule composante cellulaire du système immunitaire nécessaire et suffisante pour l’élimination de cellules infectées par des virus ou transformées, les LT CD4 ne jouant qu’un rôle auxiliaire, dans le développement et le maintien de la réponse immune effectrice, ou modulateur par la fonction suppressive des T-Reg. Aux côtés, de ces fonctions auxiliaires ou suppressive, nombre de données indiquaient que les LT CD4 pouvaient également exercer une activité cytotoxique directe. Nos travaux ont permis par l’analyse chez l’Homme, de
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Grange, Magali. "Optimisation moléculaire des fonctions anti-tumorales des LT CD8." Thesis, Aix-Marseille, 2012. http://www.theses.fr/2012AIXM4059.

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Les traitements par immunothérapie adoptive actuels sont compromis par une faible infiltration et expansion des LT CD8 injectés. Les travaux antérieurs de l'équipe ont montré une synergie entre les signaux du TCR et du récepteur à l'IL-2 pour la différenciation en Lymphocytes T (LT) effecteurs compétents, un effet qui peut être mimé par une forme constitutivement active du facteur de transcription STAT5 (STAT5CA). Mon projet de thèse à viser à exprimer ce STAT5 actif dans des LT CD8 anti-tumoraux dans le but d'augmenter leur réactivité. Nous démontrons que STAT5CA soutient l'expression de gène
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Daniel, Lauren. "Les lymphocytes T CD8 innés, une nouvelle population T non conventionnelle (re)programmée en transplantation rénale." Thesis, Poitiers, 2021. http://www.theses.fr/2021POIT1403.

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Les lymphocytes T (LT) CD8 innés sont une population de LT non conventionnels récemment décrits dans le laboratoire. On les qualifie de « non conventionnels » car ils possèdent des caractéristiques de l’immunité acquise (facteur de transcription Eomesodermine et phénotype T mémoire) mais aussi de l’immunité innée (récepteurs des cellules NK, réponse à une stimulation cytokinique de type inné). Les fonctions de ces cellules sont encore peu connues, même s’il existe un faisceau d’argument en faveur de leur implication dans l’immunité anti-infectieuse et anti-tumorale.Il a été décrit que l’immuno
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Peigné, Cassie-Marie. "Modalités fines d'activation antigénique des LT Vγ9Vδ2 humains : mécanismes de détection du stress cellulaire et implication de la butyrophiline BTN3A/CD277". Nantes, 2016. https://archive.bu.univ-nantes.fr/pollux/show/show?id=f2d45559-cfa5-42ae-a547-6aaf17d1ae3c.

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Chez la plupart des primates adultes, les lymphocytes T (LT) γ9δ2, représentant la majorité des LTγδ périphériques, jouent un rôle important dans la protection de l'organisme (ex. Agents infectieux, tumeurs). Des molécules activant spécifiquement les LTγ9δ2 ont été caractérisées et sont majoritairement des composés non-peptidiques phosphorylés appelés phosphoantigènes (PAg). Les PAg naturels correspondent à des métabolites de voies de synthèse des isoprénoïdes proches aux cellules procaryotes et eucaryotes. Les modalités d'activation des LTγ9δ2 induite par les PAg demeurent mal connues. Des do
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Mascarell, Laurent. "La cyclosporine A, un immunosuppresseur inducteur de gène : analyse protéomique in vitro et effets in vivo sur les lymphocytes T." Paris 6, 2002. http://www.theses.fr/2002PA066250.

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Lécuroux, Camille. "Génération de LT CD8+ mémoires spécifiques du VIH." Paris 11, 2009. http://www.theses.fr/2009PA11T026.

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Weulersse, Marianne. "L'absence de CD226 caractérise des LT CD8+ hyporépondeurs au TCR et aux fonctions antitumorales défectueuses." Thesis, Toulouse 3, 2019. http://www.theses.fr/2019TOU30174.

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Les lymphocytes cytotoxiques T CD8+ (LT CD8+) sont des cellules de l'immunité adaptative qui jouent un rôle majeur dans les réponses immunitaires antitumorales puisqu'ils reconnaissent et tuent spécifiquement les cellules cancéreuses. Cependant, leurs fonctions antitumorales sont souvent limitées par l'expression de récepteurs inhibiteurs tels que CTLA-4 et PD-1. Bien que les immunothérapies basées sur le blocage de ces récepteurs représentent l'une des avancées majeures dans le traitement du cancer, de nombreux cancers y sont réfractaires. Ainsi, il est aujourd'hui nécessaire de comprendre da
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Kaminski, Hannah. "Insights into the physiology of the gamma-delta T Physiologie des lymphocytes T gamma-delta dans l'interaction du cytomégalovirus avec son hôte immunodéprimé." Thesis, Bordeaux, 2020. http://www.theses.fr/2020BORD0328.

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Le cytomégalovirus est une cause infectieuse majeure de morbi-mortalité après une transplantation rénale. Une meilleure connaissance des acteurs du système immunitaire impliqués dans la réponse contre le CMV et de l'effet des médicaments immunosuppresseurs sur ces acteurs permettrait d'améliorer la prise en charge des patients. Nous avons précédemment démontré que les lymphocytes T γδ (LTγδ) (et plus particulièrement les populations n'exprimant pas la chaine Vδ2 du TCR) avaient des caractéristiques de cellules adaptatives et étaient des cellules effectrices clés répondant au CMV et associées à
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Book chapters on the topic "Lymphocytes T [LT]"

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Gualandris, Federica, Laura Castellani, and Anna Falanga. "The Association of HLA-DQ2 with Celiac Disease." In Celiac Disease. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.95837.

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DQ2 is a surface receptor of class II MHC exposed on APC immune-competent cells. Its function is to recognize non-self-antigens and present them to CD4+ T-helper lymphocytes, which activate cytokine &lt;21&gt; production and control antibody production and cell response. The activation of T lymphocytes by peptides derived from gluten proteins and the production of antibodies directed against tTG in tissues where it is localized is the basis of the etiopathogenesis of celiac disease (CD). CD is frequently associated with the presence of specific HLA system genes encoding heterodimers DQ2 and DQ8, identifiable by the DQA1*0501/DQB1*0201 or DQA1*0501/DQB1*0202 and DQB1*0302 alleles. DQ2 is also associated with genetic, endocrinological and neurological diseases such as: type 1 diabetes, thyroiditis, pancreatitis and multiple sclerosis. Interactions between DQ2 and T lymphoma have also been demonstrated. The correlation between autoimmune diseases in patients with CD and therefore DQ2 is much more frequent than in healthy subjects.
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Sinning, Joseph, and Nancy Berliner. "Granulocytes in health and disease." In Oxford Textbook of Medicine, edited by Chris Hatton and Deborah Hay. Oxford University Press, 2020. http://dx.doi.org/10.1093/med/9780198746690.003.0513.

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White cells (leucocytes) mediate inflammatory and immune responses and are key to the defence of the host against microbial pathogens. Subpopulations of leucocytes include granulocytes—neutrophils, eosinophils, and basophils; monocytes; and lymphocytes. Neutrophils comprise half the peripheral circulating leucocytes and are characterized by heterogeneous primary and secondary granules and a segmented nucleus. Maturation from the haematopoietic stem cell occurs in the bone marrow and takes 10 to 14 days. Neutrophilia—defined as an increase in the circulating neutrophil count to greater than 7.5 × 10<sup>6</sup>/µl, usually occurs as an acquired reactive response to underlying disease. Causes include infection, particularly bacterial; drugs; malignancies, and hereditary conditions. Neutropenia—defined as a reduction in the absolute neutrophil count to less than 1.5 × 10<sup>6</sup>/µl, is of particular importance because, when severe (&lt;0.5 × 10<sup>6</sup>/µl), it markedly increases the risk of life-threatening infection. Causes include drugs and toxins, postinfectious, nutritional deficiencies, autoimmune, large granular lymphocytosis, and congenital. Disorders of neutrophil function include chronic granulomatous disease, leucocyte adhesion deficiency, myeloperoxidase deficiency, and Chediak–Higashi syndrome. Monocytes share a common myeloid precursor with granulocytes, present antigens to T cells, produce several important cytokines with immunomodulatory and inflammatory functions, and are the precursors to resident tissue macrophages. They are especially important in defence against intracellular pathogens. Causes of monocytosis (&gt;0.9 × 10<sup>6</sup>/µl) include chronic infection, autoimmune diseases, and malignancy. Basophils are nonphagocytic granulocytes that function in immediate-type hypersensitivity. Basophilia (&gt; 0.2 × 10<sup>6</sup>/µl) is seen in myeloproliferative disorders, hypersensitivity reactions, and with some viral infections.
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Conference papers on the topic "Lymphocytes T [LT]"

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Filippi, J. F., D. Arnoux, N. Tubiana, et al. "PLASMINOGEN ACTIVATOR ACTIVITY OF NORMAL AND MALIGNANT MONONUCLEAR HUMAN CELLS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643167.

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Plasminogen activators (PA) are thought to play a role in the invasive and metastatic properties of many types of cancer cells. Though, discrepancies in correlations between fibrinolytic activity and metastatic potential of malignant cells have been described.In this study, we evaluated both tissue type (tPA) and urokinase type (UK) cellular PA activities in different mononuclear cell types : normal T and B human peripheral lymphocytes, B cells from patients with chronic lymphocytic leukemia (CLL), human blood monocytes, alveolar macrophages, U 937, RAJI and JM cell 1ines.Mononuclear cells wer
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