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Journal articles on the topic 'Lymphocytes T [LT]'

Author: Grafiati

Published: 4 June 2021

Last updated: 17 February 2022

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1

Chen, Lin-Ying, Julia Y. S. Tsang, Yun-Bi Ni, et al. "Lymphocyte subsets contribute to the degree of lobulitis and ductitis in sclerosing lymphocytic lobulitis of the breast." Journal of Clinical Pathology 69, no. 6 (2015): 527–32. http://dx.doi.org/10.1136/jclinpath-2015-203334.

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AimsSclerosing lymphocytic lobulitis (SLL) of the breast is characterised by lymphocytic lobulitis, ductitis, vasculitis and dense keloidal fibrosis with epithelioid fibroblasts. However, the subsets of the infiltrating lymphocytes and their contribution to disease progression have not been fully explored.MethodsCD20, CD3, CD4, CD8 and regulatory T (Treg) lymphocytes were evaluated in the epithelial and vascular areas in SLL. The relationship between the lymphocyte subset in different regions and the degree of inflammation was analysed.ResultsLymphocytic infiltration was mainly located in peri

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Park, Suk W., Walter Royal, Richard D. Semba, Gordon W. Wiegand, and Diane E. Griffin. "Expression of Adhesion Molecules and CD28 on T Lymphocytes during Human Immunodeficiency Virus Infection." Clinical Diagnostic Laboratory Immunology 5, no. 4 (1998): 583–87. http://dx.doi.org/10.1128/cdli.5.4.583-587.1998.

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ABSTRACT Adhesion molecules, which play a major role in lymphocyte circulation, have not been well characterized in human immunodeficiency virus (HIV) infection. T-lymphocyte populations, including CD3, CD4, CD28, and adhesion molecules (L selectin, LFA-1, VLA-4, and ICAM-1) were measured by flow cytometry in a cross-sectional study of 100 HIV-infected and 49 HIV-seronegative adults. HIV-infected adults had lower numbers of CD3+ lymphocytes expressing L selectin (P < 0.0001) and VLA-4 (P < 0.01) and higher numbers of CD3+ lymphocytes expressing LFA-1bright (P < 0.002) than did HIV-neg

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Chen, Yang, Yanyan Xie, Min Ruan та Jinning Shi. "The Levels of T Lymphocyte Subsets in Immune Thrombocytopenia Associated with Anti-GPIIb/IIIa- and/or Anti-GPIbα-Mediated Responses Are Differentially Sensitive to Dexamethasone". Acta Haematologica 140, № 1 (2018): 60–66. http://dx.doi.org/10.1159/000491977.

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Objective: The aim of this work was to investigate the influence of T lymphocyte subsets and platelet-specific autoantibodies on immune thrombocytopenia (ITP) with dexamethasone therapy. Methods: The samples were obtained from patients before therapy. T lymphocyte subsets were measured by flow cytometry, and platelet-specific autoantibodies were evaluated by modified monoclonal antibody immobilization of platelet antigen assay. Results: A total of 50 ITP patients were involved in the study. Twenty-three were anti-GPIbα antibody positive and were treated with dexamethasone, with a response rate

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Morice, William G., Paul J. Kurtin, Ayalew Tefferi, and Curtis A. Hanson. "Distinct bone marrow findings in T-cell granular lymphocytic leukemia revealed by paraffin section immunoperoxidase stains for CD8, TIA-1, and granzyme B." Blood 99, no. 1 (2002): 268–74. http://dx.doi.org/10.1182/blood.v99.1.268.

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Unlike other leukemia types in which the bone marrow findings are diagnostic, the bone marrow pathology of T-cell granular lymphocytic leukemia (GLL) is subtle and ill-defined. In this study, bone marrow biopsy specimens from 36 patients with T-cell GLL and from 25 control patients with cytopenias and relative or absolute increases in blood large granular lymphocytes were studied by immunohistochemistry using antibodies to the cytolytic lymphocyte antigens CD8, CD56, CD57, TIA-1, and granzyme B. The goals were to clarify the bone marrow pathology of T-cell GLL and to refine the diagnostic crit

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Kopecký, Otakar, Šárka Lukešová, Vladimíra Vroblová, et al. "Phenotype Analysis of Tumour-infiltrating Lymphocytes and Lymphocytes in Peripheral Blood in Patients with Renal Carcinoma." Acta Medica (Hradec Kralove, Czech Republic) 50, no. 3 (2007): 207–12. http://dx.doi.org/10.14712/18059694.2017.84.

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Introduction: When checking tumour growth, a number of observations indicate that the immune system plays a significant role in patients with renal cell carcinoma (RCC). Infiltration by lymphocytes (tumour infiltrating lymphocytes, TILs) is more prevalent in RCC than any other tumours. T lymphocytes are the dominant population of TIL cells. Views concerning the role of T lymphocytic subpopulations, B lymphocytes and NK cells in an anti-tumour response are not established. Aim: The aim is to determine the phenotype and activation of T and B lymphocytic subpopulations and NK cells and to compare

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Qiang, Wu, Lu Chunxiao, Wu Jiafeng, et al. "Association of T lymphocytes level and clinical severity in patients of COVID-19 in Shenzhen China." European Journal of Inflammation 19 (January 2021): 205873922110144. http://dx.doi.org/10.1177/20587392211014409.

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To explore the correlation between T lymphocytes and clinical severity in patients of COVID-19. A total of 183 COVID-19 patients were recruited in Shenzhen Third People’s Hospital from January 11 to February 16, 2020. According to the clinical classification criteria, they were divided into severe group (46 cases) and non-severe (137cases). T lymphocyte counts, lymphocyte subpopulation, IL-6 levels, and clinical outcomes were compared between the two groups. Compared with the non-severe group, the lymphocyte count, T lymphocyte count, T lymphocyte percentage, CD4+ T lymphocyte count, CD4+ T ly

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Lancaster, G. I., Q. Khan, P. T. Drysdale, et al. "Effect of prolonged exercise and carbohydrate ingestion on type 1 and type 2 T lymphocyte distribution and intracellular cytokine production in humans." Journal of Applied Physiology 98, no. 2 (2005): 565–71. http://dx.doi.org/10.1152/japplphysiol.00754.2004.

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The present study was undertaken to examine the role of the exercise-induced stress hormone response on the regulation of type 1 and type 2 T lymphocyte intracellular cytokine production. Subjects performed 2.5 h of cycling exercise at 65% maximal O2 uptake while ingesting a 6.4% carbohydrate (CHO) solution, 12.8% CHO solution, or a placebo. Peripheral whole blood samples were stimulated and stained for T lymphocyte surface antigens (CD4 and CD8). Cells were then permeabilized, stained for intracellular cytokines, and analyzed using flow cytometry. Exercise resulted in a decrease ( P < 0.05

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Shi, Chenyuan, Chaoqun Hou, Xiaole Zhu, et al. "New Predictor of Organ Failure in Acute Pancreatitis: CD4+ T Lymphocytes and CD19+ B Lymphocytes." BioMed Research International 2018 (December 5, 2018): 1–8. http://dx.doi.org/10.1155/2018/1012584.

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Objective. Lymphocytes are one of the main effector cells in the inflammatory response of acute pancreatitis (AP). The purpose of the study was to evaluate whether peripheral blood lymphocyte (PBL) subsets at admission change during AP based on clinical outcomes and to explore whether these changes vary by aetiology of AP. Hence, we performed a prospective study to find a predictor in lymphocyte subsets that might allow easier, earlier, and more accurate prediction of clinical outcomes. Methods. Patients with AP were enrolled from December 2017 to June 2018 at the First Affiliated Hospital of

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Kaur, Amitinder, Michele Di Mascio, Amy Barabasz, et al. "Dynamics of T- and B-Lymphocyte Turnover in a Natural Host of Simian Immunodeficiency Virus." Journal of Virology 82, no. 3 (2007): 1084–93. http://dx.doi.org/10.1128/jvi.02197-07.

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ABSTRACT Increased lymphocyte turnover is a hallmark of pathogenic lentiviral infection. To investigate perturbations in lymphocyte dynamics in natural hosts with nonpathogenic simian immunodeficiency virus (SIV) infection, the nucleoside analog bromodeoxyuridine (BrdU) was administered to six naturally SIV-infected and five SIV-negative sooty mangabeys. As a measure of lymphocyte turnover, we estimated the mean death rate by fitting a mathematical model to the fraction of BrdU-labeled cells during a 2-week labeling and a median 10-week delabeling period. Despite significantly lower total T- a

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Simpson, Richard J., Geraint D. Florida-James, Cormac Cosgrove, et al. "High-intensity exercise elicits the mobilization of senescent T lymphocytes into the peripheral blood compartment in human subjects." Journal of Applied Physiology 103, no. 1 (2007): 396–401. http://dx.doi.org/10.1152/japplphysiol.00007.2007.

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Clonal expansion of T lymphocytes in response to antigenic stimulation is a fundamental process of adaptive immunity. As a consequence of clonal expansion, some T lymphocytes acquire a senescent phenotype, fail to replicate in response to further antigenic stimulation, and express the killer cell lectin-like receptor G1 (KLRG1) and/or CD57. Physical exercise elicits a mobilization of large numbers of T lymphocytes into the bloodstream from peripheral lymphoid compartments, but the frequency of senescent cells in the mobilized population is not known. Eight male runners (age: 29 ± 9 yr; maximal

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Huang, Wenhan, FeiFeng Ren, Lei Luo, et al. "The characteristics of lymphocytes in patients positive for anti-MDA5 antibodies in interstitial lung disease." Rheumatology 59, no. 12 (2020): 3886–91. http://dx.doi.org/10.1093/rheumatology/keaa266.

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Abstract Objective The aim was to investigate the characteristics of blood lymphocytes in patients positive for anti-melanoma differentiation-associated gene 5 antibodies (anti-MDA5+) in interstitial lung disease. Methods Thirty-eight anti-MDA5+ patients with interstitial lung disease were admitted to our hospital, and the lymphocyte count, lymphocyte subtypes and lung high-resolution CT were recorded. Some of the cases were examined by bone marrow aspiration. Results Compared with the control group, the blood lymphocyte counts of anti-MDA5+ patients before treatment were significantly lower (

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Avdeeva, A. S., Yu P. Rubtsov, T. V. Popkova, D. T. Dyikanov, A. P. Aleksankin, and E. L. Nasonov. "FEATURES OF THE PHENOTYPE OF REGULATORY T CELLS IN EARLY AND ADVANCED RHEUMATOID ARTHRITIS." Rheumatology Science and Practice 56, no. 4 (2018): 423–28. http://dx.doi.org/10.14412/1995-4484-2018-423-428.

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Objective: to analyze the levels of CD3+, CD3+CD4+, CD3+CD8+, and CD3-CD56+ T lymphocytes, FoxP3+ regulatory T cells (Treg), and CD19+ B lymphocytes in patients with early and advanced rheumatoid arthritis (RA). Subjects and methods. The investigation enrolled 45 patients previously untreated with methotrexate (MTX-naive) who had early RA and 15 patients who had advanced RA. Immunofluorescence staining and multicolor flow cytometry assays were used to estimate the percentage and absolute (abs) counts of CD3+, CD3+CD4+, CD3+CD8+, CD3-CD16+CD56+, CD19+, Treg(FoxP3+CD25+; surface CD152+; intracel

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Nikipelova, Elena A., and Oleg I. Kit. "Local infiltration of lymphocytes in large bowel tissue cancer and chronic colitis." Journal of Clinical Oncology 30, no. 15_suppl (2012): e21101-e21101. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.e21101.

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e21101 Background: comparative analysis of concentrations of lymphocyte subpopulations in tissue of various intestinal zones in cancer of large bowel and chronic atrophic colitis. Methods: subpopulation composition of T- (CD3, CD4, CD8) and B- (CD19) lymphocytes, natural killers NK (CD16CD56), and T-lymphocytes with antigen-recognizing receptors TCRαβ and TCRγδ were examined in bowel adenocarcinoma tissue, peritumoural zone (1-3 cm away from tumour) and in resection line (10 cm away from tumour edge) and in chronic colitis tissue. Flow cytofluorimetry was used for immunophenotyping of the lymp

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Cuturi, M. C., M. Murphy, M. P. Costa-Giomi, R. Weinmann, B. Perussia, and G. Trinchieri. "Independent regulation of tumor necrosis factor and lymphotoxin production by human peripheral blood lymphocytes." Journal of Experimental Medicine 165, no. 6 (1987): 1581–94. http://dx.doi.org/10.1084/jem.165.6.1581.

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We present evidence that human peripheral blood lymphocytes, free of contaminating monocytes, rapidly produce high levels of tumor necrosis factor (TNF) when stimulated with phorbol diester and calcium ionophore, and lower but significant levels of TNF when stimulated with mitogens. These two types of inducers act preferentially on T cells, both CD4+ and CD8+. NK cells produce TNF only when stimulated with phorbol diester and calcium ionophore, and they do so at a much lower level than T cells. The procedures used in the purification of lymphocytes and the differential ability to respond to va

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Sundin, Mikael, A. John Barrett, Olle Ringdén, et al. "HLA Mismatched MSC Suppress T Lymphocyte Allo responses in Vitro and Do Not Induce Immunological Memory in Recipients of MSC Infusion." Blood 112, no. 11 (2008): 4740. http://dx.doi.org/10.1182/blood.v112.11.4740.4740.

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Abstract Multipotent mesenchymal stromal cells (MSC) are increasingly used to treat refractory graft-versus-host-disease and other complications in HLA-matched and mismatched hematopoietic stem cell transplantation (HSCT) patients. We evaluated immunogenicity of human allogeneic MSC infused post-transplant to HLA-mismatched, i.e. patients undergoing HSCT. We compared recipient lympho cyte response to MSC and peripheral blood lymphocytes (PBL) from the MSC or third party donors before and after infusion, and lymphocyte responses to MSC and to PBL from the MSC donor in primary and secondary chal

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Walusimbi, S. S., L. M. Wetzel, D. H. Townson, and J. L. Pate. "Isolation of luteal endothelial cells and functional interactions with T lymphocytes." Reproduction 153, no. 5 (2017): 519–33. http://dx.doi.org/10.1530/rep-16-0578.

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The objectives of this study were to optimize the isolation of luteal endothelial cells (LEC) and examine their functional interactions with autologous T lymphocytes. Analysis by flow cytometry showed that the purity of LEC isolated by filtration was nearly 90% as indicated byBandeiraea simplicifolia(BS)-1 lectin binding. LEC expressed mRNA for progesterone receptor (PGR), prostaglandin receptors (PTGFR, PTGER2 and 4, and PTGIR), tumor necrosis factor receptors (TNFRSF1A&B) and interleukin (IL) 1B receptors (IL1R1&2). LEC were pretreated with either vehicle, progesterone (P4; 0–20 µM),

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de Gast, G. C., F. A. Vyth-Dreese, W. Nooijen, et al. "Reinfusion of Autologous Lymphocytes With Granulocyte-Macrophage Colony-Stimulating Factor Induces Rapid Recovery of CD4+ and CD8+ T Cells After High-Dose Chemotherapy for Metastatic Breast Cancer." Journal of Clinical Oncology 20, no. 1 (2002): 58–64. http://dx.doi.org/10.1200/jco.2002.20.1.58.

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PURPOSE: Repeated high-dose chemotherapy (HDCT) followed by peripheral-blood progenitor cell (PBPC) transplantation can induce a complete remission in patients with metastatic breast cancer sensitive to standard chemotherapy (CT), but the majority of patients relapse within 1 to 2 years. The immune system is seriously compromised after HDCT, which precludes the development of effective immunotherapy. We investigated whether autologous lymphocytes, reinfused after HDCT, could induce a rapid recovery of T cells. PATIENTS AND METHODS: Three patients were monitored for immune recovery without rein

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Shichishima, Akiko, Hideyoshi Noji, Kazuhiko Ikeda, Yukio Maruyama та Tsutomu Shichishima. "High Frequencies of Increased Interferon-γ-Producing and/or Skewed CD8+ T Lymphocyte Subfamilies in Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH)." Blood 108, № 11 (2006): 980. http://dx.doi.org/10.1182/blood.v108.11.980.980.

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Abstract Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal hematological disorder affecting all hematopoietic lineages, which lack glycosylphosphatidylinositol (GPI)-anchored membrane proteins due to somatic mutations in the phosphatidylinositol glycan-class A gene, and is one disorder of bone marrow failure (BMF) syndromes. Autoreactive T lymphocytes are implicated in some of the immune mechanisms involved in PNH. In fact, we reported recently that the HLA-DRB1*1501 allele and HLA-A*0206 allele is frequent and is related to grading of hemolysis, respectively, in PNH patients (Sh

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Duda, Y. V. "Cellular immunity of rabbits incase of parasite association (Treponema cuniculi and Eimeria sp.)." Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies 21, no. 96 (2019): 8–13. http://dx.doi.org/10.32718/nvlvet9602.

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Despite a huge number of studies, the uniqueness of antiparasitic immunity is so great that there is still insufficient knowledge of the factors contributing to the manifestation of the characteristics of immunity in mixed parasitic diseases of rabbits. Therefore, the question of the influence of the association of pathogens Treponema cuniculi and Eimeria sp. on indicators of cellular immunity of rabbits is relevant. The study was conducted on 59 male rabbits age 3–5 months of the Californian breed, selected by analogy. Animal were separated into two groups: healthy animals (control group) and

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Tonetti, Cláudia Rodrigues, Caroline Natânia de Souza-Araújo, Adriana Yoshida, et al. "Ovarian Cancer-Associated Ascites Have High Proportions of Cytokine-Responsive CD56bright NK Cells." Cells 10, no. 7 (2021): 1702. http://dx.doi.org/10.3390/cells10071702.

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Ovarian cancer is the most lethal gynecological malignancy, with serous histotype as the most prevalent epithelial ovarian cancer (EOC). Peritoneal ascites is a frequent comorbidity in advanced EOC. EOC-associated ascites provide a reliable sampling source for studying lymphocytes directly from tumor environment. Herein, we carried out flow cytometry-based analysis to readdress issues on NK and T lymphocyte subsets in women with advanced EOC, additionally evaluating phenotypic modulation of their intracellular pathways involved in interleukin (IL)-2 and IL-15 signaling. Results depicted ascite

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Rokyta, R., M. Holub, M. MatĔjovič, et al. "Continuous Venovenous Hemofiltration: Effects on Monocyte and Lymphocyte Immunophenotype in Critically Ill Patients." International Journal of Artificial Organs 25, no. 11 (2002): 1066–73. http://dx.doi.org/10.1177/039139880202501105.

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The aim of this study was to test the hypothesis that continuous venovenous hemofiltration (CVVH) increases HLA-DR expression on monocytes and T lymphocytes in critically ill patients. 24 septic (SP) and 10 non-septic (NSP) medical ICU patients with acute renal failure were studied prospectively. The ultrafiltration rate was 20–30 ml.kg-1.h-1. The total and differential white cell counts were measured and CD3+ lymphocyte count, HLA-DR expression on CD14+ monocytes and CD3+ lymphocytes were analysed by two-colour flow cytometry before, 4 and 24 h after CVVH initiation, respectively. CVVH did no

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Chao, Tony, Belinda I. Gomez, Tiffany C. Heard, Michael A. Dubick, and David M. Burmeister. "Increased oxidative phosphorylation in lymphocytes does not atone for decreased cell numbers after burn injury." Innate Immunity 26, no. 5 (2020): 403–12. http://dx.doi.org/10.1177/1753425918805544.

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The acute systemic inflammatory response syndrome (SIRS) and multiorgan dysfunction (MOD) that occur in large burn injuries may be attributed, in part, to immunosuppressive responses such as decreased lymphocytes. However, the mitochondrial bioenergetics of lymphocytes after severe burn injury are poorly understood. The purpose of this study was to examine mitochondrial function of lymphocytes following severe burns in a swine model. Anesthetized Yorkshire swine ( n = 17) sustained 40% total body surface area full-thickness contact burns. Blood was collected at pre-injury (Baseline; BL) and at

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Starkie, R. L., J. Rolland, and M. A. Febbraio. "Effect of adrenergic blockade on lymphocyte cytokine production at rest and during exercise." American Journal of Physiology-Cell Physiology 281, no. 4 (2001): C1233—C1240. http://dx.doi.org/10.1152/ajpcell.2001.281.4.c1233.

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To examine the effect of exercise and adrenergic blockade on lymphocyte cytokine production, six men ingested either a placebo (control) or an α- (prazosin hydrochloride) and β-adrenoceptor antagonist (timolol malate) capsule (blockade, or BLK) 2 h before performing 19 ± 1 min of supine bicycle exercise at 78 ± 3% peak pulmonary uptake. Blood was collected before and after exercise, stimulated with phorbol 12-myristate 13-acetate and ionomycin, and surface stained for T (CD3+) and natural killer [NK (CD3−CD56+)] lymphocyte surface antigens. Cells were permeabilized, stained for the intracellul

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Gomatos, Ilias P., Leonidas Alevizos, Olga Kalathaki, et al. "Changes in T-Lymphocytes' Viability After Laparoscopic Versus Open Cholecystectomy." International Surgery 100, no. 4 (2015): 696–701. http://dx.doi.org/10.9738/intsurg-d-14-00137.1.

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Laparoscopic surgery results in decreased immune and metabolic stress response compared to open surgery. Our aim was to evaluate the suspension of host immune defense in terms of apoptosis, necrosis, and survival of peripheral T-lymphocytes in patients undergoing laparoscopic versus open cholecystectomy. Apoptosis, necrosis and viability of peripheral T-lymphocytes were measured preoperatively and postoperatively by means of flow cytometry in 27 patients undergoing laparoscopic cholecystectomy and 25 undergoing open cholecystectomy. White cell count, CRP, and serum glucose levels were also mea

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Furmanova, O. V., A. V. Kulikovska, V. V. Popova, K. P. Zak, and M. D. Tronko. "Immunophenotype of blood lymphocytes in patients with type 2 diabetes and normal body weight and obesity." INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine) 17, no. 2 (2021): 108–15. http://dx.doi.org/10.22141/2224-0721.17.2.2021.230564.

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Background. Determination of the blood lymphocyte immunophenotype is one of the key indicators of the immune function in a diseased person. However, the studies of the lymphocyte immunophenotyping in patients with type 2 diabetes (T2D), with the most frequent complication of this disease — overweight/obesity, are rare and controversial. The purpose of study was to determine immunophenotype of blood lymphocytes (CD3+ T, CD4+ T, CD8+ T, CD20+ and CD56+ cells) in patients with newly diagnosed T2D and different body mass index (BMI). Materials and methods. There were examined 78 patients with newl

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Chikamatsu, Kazuaki, Masao Eura, Koji Nakano, Yuichi Kanzaki, Keisuke Masuyama та Takeru Ishikawa. "T-Cell Receptor Vβ Gene Rearrangements of T Lymphocytes Infiltrating the Mucosa in Chronic Sinusitis". American Journal of Rhinology 9, № 6 (1995): 347–52. http://dx.doi.org/10.2500/105065895781808784.

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Lymphocytic infiltration within the mucosa of patients with chronic sinusitis may reflect an in situ immune reaction. An analysis of the T-cell receptor (TCR) expressed by these lymphocytes may help to understand T-cell immunity in chronic sinusitis. We analyzed the TCR Vβ gene rearrangements in T cells that infiltrated the mucosa of the maxillary sinuses in 24 patients with chronic sinusitis using the reverse transcription polymerase chain reaction method. The analysis of the TCR Vβ repertoire revealed a significant limited usage (P < 0.01) of the Vβ gene families, compared with peripheral

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Xu, Linxinyu, Tianshu Yang, Shaobo Su, and Fang Wang. "2-Methoxyestradiol Alleviates Experimental Autoimmune Uveitis by Inhibiting Lymphocytes Proliferation and T Cell Differentiation." BioMed Research International 2016 (2016): 1–8. http://dx.doi.org/10.1155/2016/7948345.

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Purpose. To investigate the effect of 2-Methoxyestradiol (2ME2) on experimental autoimmune uveitis (EAU) and the mechanism.Method. C57BL/6 male mice were used to establish the EAU model. 2ME2 was abdominal administrated in D0–D13, D0–D6, and D7–D13 and control group was given vehicle from D0–D13. At D14, pathological severity was scored. Lymphocyte reaction was measured using MTT assay. T cell differentiation in draining lymph nodes and eye-infiltrating cells was tested by flow cytometry. Proinflammatory cytokines production from lymphocytes was determined by ELISA.Result. The disease scores f

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Shao, Zonghong, Jun Wang, Rong Fu, et al. "In Vitro Study of the Function of Dendritic Cells on Stimulating T Lymphocytes Proliferation in Severe Aplastic Anemia." Blood 112, no. 11 (2008): 4919. http://dx.doi.org/10.1182/blood.v112.11.4919.4919.

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Abstract Objective To investigate the function of dendritic cells (DCs) in severe aplastic anemia (SAA). Methods Fifteen untreated patients, 10 recovered patients with SAA and 12 normal controls were enrolled in this study. Their mDCs were induced from their bone marrow mononuclear cells with rhIL-4, rhGM-CSF and rhTNF in vitro. Then mDCs were co-cultured with allogenic lymphocytes (mixture lymphocyte reaction, MLR). The growth rate of lymphocyte was measured by MTT colorimetry and the concentrations of IL-12 and IFNγ in MLR supernatant were measured by ELISA. The correlation between the growt

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Fleischer, Vinzenz, Michaela Friedrich, Ayman Rezk, et al. "Treatment response to dimethyl fumarate is characterized by disproportionate CD8+ T cell reduction in MS." Multiple Sclerosis Journal 24, no. 5 (2017): 632–41. http://dx.doi.org/10.1177/1352458517703799.

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Background: The effect of dimethyl fumarate (DMF) on circulating lymphocyte subsets and their contribution as predictors of clinical efficacy have not yet been investigated in multiple sclerosis (MS). Objective: To evaluate lymphocytes and lymphocyte subsets (analyzed 6 months after DMF start) in MS patients with and without disease activity after 1 year of treatment in a retrospective study. Methods: Peripheral blood lymphocyte subsets were analyzed by flow cytometry. Untreated MS patients ( n = 40) were compared to those 6 months after onset of DMF treatment ( n = 51). Clinical and magnetic

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Muto, Satoshi, Hayato Mine, Hironori Takagi, et al. "Can immunologically hot lung cancer be distinguished from cold tumor by peripheral blood?" Journal of Clinical Oncology 38, no. 5_suppl (2020): 48. http://dx.doi.org/10.1200/jco.2020.38.5_suppl.48.

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48 Background: Depending on the number of tumor infiltrating lymphocytes, immunological cold to hot conditions vary. There are several clinical trials of administering immune checkpoint inhibitors as perioperative adjuvant therapy. Immune checkpoint inhibitors are generally effective in immunologically hot conditions. However, biopsy specimens are not enough to determine the amount of tumor infiltrating lymphocytes. Therefore, we focused on effector T lymphocytes in peripheral blood, and tried to understand the tumor microenvironment by looking at peripheral blood. Methods: Twenty-four patient

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Avgustin, Bojana, Vladimir Kotnik, Mojca Škoberne, Tadej Malovrh, Aleksandra Skralovnik-Stern, and Marjeta Terčelj. "CD69 Expression on CD4+ T Lymphocytes after In Vitro Stimulation with Tuberculin Is an Indicator of Immune Sensitization against Mycobacterium tuberculosis Antigens." Clinical Diagnostic Laboratory Immunology 12, no. 1 (2005): 101–6. http://dx.doi.org/10.1128/cdli.12.1.101-106.2005.

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ABSTRACT The expression of the CD69 antigen on CD4 T lymphocytes after in vitro stimulation with purified protein derivative (2 tuberculin units) was used to evaluate the tuberculin reactivities of 52 individuals from four experimental groups: Mycobacterium bovis BCG-vaccinated healthy individuals with a negative tuberculin skin test (TST) result (group A), BCG-vaccinated healthy individuals with a positive TST result (group B), patients with active tuberculosis (TB) before treatment (group C), and individuals with clinically inactive TB who had previously completed a prescribed course of chem

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Yu, Qianli, Ronald R. Watson, John J. Marchalonis, and Douglas F. Larson. "A role for T lymphocytes in mediating cardiac diastolic function." American Journal of Physiology-Heart and Circulatory Physiology 289, no. 2 (2005): H643—H651. http://dx.doi.org/10.1152/ajpheart.00073.2005.

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The induction of T helper (TH) lymphocytes by distinct TH ligands results in a differentiation to TH1/TH2 subsets based on their unique pattern of cytokine secretion and effector functions. We hypothesized that the relative proportion of TH1/TH2 directly relates to cardiac fibroblast (CF) function and thereby cardiac extracellular matrix (ECM) composition and cardiac diastolic function in the absence of injury or altered wall stress. We compared the effect of selective TH1 with TH2 inducers on cardiac gene expression, ECM composition, and diastolic function in C57BL/J mice. Twelve weeks after

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Quattrocchi, Keith B., Claramae H. Miller, Franklin C. Wagner, et al. "Cell-mediated immunity in severely head-injured patients: the role of suppressor lymphocytes and serum factors." Journal of Neurosurgery 77, no. 5 (1992): 694–99. http://dx.doi.org/10.3171/jns.1992.77.5.0694.

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✓ Severe head injury results in suppression of cellular immunity associated with defective in vitro functioning of effector lymphocytes, such as helper T cells and cytotoxic T cells. It is not known whether this suppression in effector lymphocyte function is due to intrinsic lymphocyte dysfunction, to suppressor peripheral blood mononuclear cells (PBMC's) such as suppressor lymphocytes or suppressor monocytes, or to serum factors capable of inhibiting effector lymphocyte function. The purpose of this study was to determine whether a subpopulation of PBMC's and/or serum factors) are responsible

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Grubeck-Loebenstein, B., H. Kassal, P. P. A. Smyth, K. Krisch, and W. Waldhäusl. "The prevalence of immunological abnormalities in endemic simple goitre." Acta Endocrinologica 113, no. 4 (1986): 508–13. http://dx.doi.org/10.1530/acta.0.1130508.

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Abstract. Thyroid growth stimulating immunoglobulins microsomal antibodies and antibodies against thyroglobulin were determined in patients with simple goitre (n = 20) and controls (n = 6) living in an iodine deficient area. In addition, lymphocytic infiltration of thyroid tissue, the amount of the various lymphocyte subsets (Leu 4+, Leu 3a+, and Leu 2a+ T-cells as well as B1+ B cells) in the thyroid gland, as well as the expression of the histocompatibility antigen HLA-DR on thyrocytes and intrathyroidal T-lymphocytes were examined. Goitrous patients were subdivided into two groups according

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Lim, Lony C. L., Michelle N. Fiordalisi, Janet L. Mantell, John L. Schmitz, and James D. Folds. "A Whole-Blood Assay for Qualitative and Semiquantitative Measurements of CD69 Surface Expression on CD4 and CD8 T Lymphocytes Using Flow Cytometry." Clinical Diagnostic Laboratory Immunology 5, no. 3 (1998): 392–98. http://dx.doi.org/10.1128/cdli.5.3.392-398.1998.

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ABSTRACT A whole-blood flow cytometry-based assay was utilized to assess CD4 and CD8 T-lymphocyte activation in response to phytohemagglutinin (PHA) stimulation. T-lymphocyte activation was assessed by qualitative (percent CD69) and semiquantitative (anti-CD69 antibody binding capacity) measurements of CD69 surface expression. Whole-blood samples from 21 healthy and 21 human immunodeficiency virus (HIV)-infected (<500 absolute CD4 counts per mm3) individuals were stimulated with 20 μg of PHA per ml for 18 to 24 h. The proportions of activated CD4 and CD8 T lymphocytes expressing CD69 (perce

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Nájera, Oralia, Cristina González, Guadalupe Toledo, Laura López, and Rocío Ortiz. "Flow Cytometry Study of Lymphocyte Subsets in Malnourished and Well-Nourished Children with Bacterial Infections." Clinical Diagnostic Laboratory Immunology 11, no. 3 (2004): 577–80. http://dx.doi.org/10.1128/cdli.11.3.577-580.2004.

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ABSTRACT Protein-energy malnutrition is the primary cause of immune deficiency in children across the world. It has been related to changes in peripheral T-lymphocyte subsets. The aim of the present study was to evaluate the effects of infection and malnutrition on the proportion of peripheral-lymphocyte subsets in well-nourished non-bacterium-infected (WN), well-nourished bacterium-infected (WNI), and malnourished bacterium-infected (MNI) children by flow cytometry. A prospectively monitored cohort of 15 MNI, 12 WNI, and 17 WN children was studied. All the children were 3 years old or younger

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Nielsen, Jeppe Sylvest, Anders Larsson, Vibeke Brix-Christensen, Jens Randel Nyengaard, Thomas Ledet, and Else Tønnesen. "Endotoxemia-induced Lymphocyte Apoptosis Is Augmented by a Hyperinsulinemic–Euglycemic Clamp." Anesthesiology 102, no. 4 (2005): 768–73. http://dx.doi.org/10.1097/00000542-200504000-00012.

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Background Sepsis and endotoxemia are associated with lymphocyte apoptosis. This has been regarded as harmful, contributing to further immune suppression in already immune-compromised patients. Because normalization of blood glucose improves outcome in critically ill patients, the authors hypothesized that one of the effects of insulin and normoglycemia would be inhibition of lymphocyte apoptosis. Therefore, in this experimental study in pigs, the authors examined the separate and combined effects of acute endotoxemia and a hyperinsulinemic-euglycemic clamp (HEC) on lymphocyte apoptosis. Metho

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Symeonidis, Argiris S., George Theodorou, Constantina Repa, et al. "Impaired T-Lymphocyte Subpopulations and Deranged Profile of Immunologic Activation in Patients with Gaucher Disease Type I." Blood 112, no. 11 (2008): 4915. http://dx.doi.org/10.1182/blood.v112.11.4915.4915.

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Abstract Patients with Gaucher disease exhibit substantial evidence of impairment of their immune system, namely, increased serum levels of proinflammatory cytokines and immunoglobulins, and increased incidence of B-cell malignancies, such as non-Hodgkin’s lymphoma, MGUS and multiple myeloma. We investigated peripheral blood T-lymphocyte subpopulations with dual color flow cytometry, as well as the direction of T-lymphocyte activation, by using intracytoplasmic immunostaining for IL-2, IL-4, IL-10 and IFN-gamma, on resting CD4+ and CD8+ T-lymphocytes and following activation with PMA- 1 with t

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Toldi, Gergely, Nóra Legány, Imre Ocsovszki, and Attila Balog. "Calcium Influx Kinetics and the Characteristics of Potassium Channels in Peripheral T Lymphocytes in Systemic Sclerosis." Pathobiology 87, no. 5 (2020): 311–16. http://dx.doi.org/10.1159/000509674.

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<b><i>Background:</i></b> Systemic sclerosis (SSc) is a chronic, immune-mediated, connective tissue disease causing microvascular abnormalities and fibrosis. The cytoplasmic calcium influx kinetics in T lymphocytes governs lymphocyte activation in this inflammatory process. The inhibition of Kv1.3 and IKCa1 potassium channels reduces calcium influx. <b><i>Methods:</i></b> This study aimed to analyze cytoplasmic calcium influx kinetics following activation in Th1, Th2, and CD8 cells in peripheral blood of 12 healthy individuals and 16 patients wit

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Filipovic, A., I. Paunovic, and Lj Vuckovic. "Influence of lymphocitic thyroiditis on prognostic outcome differentiated thyroid carcinoma." Acta chirurgica Iugoslavica 57, no. 2 (2010): 85–94. http://dx.doi.org/10.2298/aci1002085f.

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Backgraund/aim. Thyroid carcinoma is rare malignant tumors. They are typically presented with slow progression and clinical course. Lymphocytic infiltration, including fagocytosis of neoplastic cells by macrophage plays an important role in preventing development of distant metastases. This paper sets the following objectives: Establish whether presence or absence of Hashimoto thyroiditis in differentiated thyroid carcinoma (DTC) is a favourable prognostic factor. Methods. The group under examination here are all newly diagnosed patients with differentiated thyroid carcinoma surgically treated

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Sabin, Caroline A., Amanda Mocroft, Margarita Bofill, et al. "Changes in Lymphocyte Subsets in Human Immunodeficiency Virus‐Positive Persons with <5 CD4 T Lymphocytes/mm3." Journal of Infectious Diseases 178, no. 4 (1998): 1166–69. http://dx.doi.org/10.1086/515676.

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Miyara, M., Z. Amoura, C. Parizot, et al. "Étude des lymphocytes T régulateurs (LT reg) au cours de la sarcoïdose." La Revue de Médecine Interne 24 (June 2003): 60s. http://dx.doi.org/10.1016/s0248-8663(03)80090-5.

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Yan, Catherine T., Ji hye Park, Parames Muniandy, Logan Troppito, and Robert Welner. "Lig4 R278H Mutation Impacts on LT-HSC Functions, Cancer Development and Aging." Blood 118, no. 21 (2011): 1350. http://dx.doi.org/10.1182/blood.v118.21.1350.1350.

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Abstract Abstract 1350 DNA Ligase IV (Lig4) is an essential component of the non-homologous end-joining (NHEJ) repair pathway, essential for the end-ligation of broken DNA ends generated during V(D)J recombination and IgH Class Switch Recombination (CSR) in B lymphocytes. Mutations in Lig4 underlie the DNA Lig4 Syndrome, a rare herited immunodeficiency disease. We have modeled one such mutation in mice, a homozygous arginine to histidine 278 (R278H) change with the enzyme active site, which others and we have shown significantly impairs the catalytic end-ligation activity of the LigIV protein.

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Moskaliuk, V. D., and T. R. Kolotylo. "CHARACTERISTICS OF SOME IMMUNOLOGICAL INDICATORS OF HIV INFECTION IN COMBINATION WITH TUBERCULOSIS." Інфекційні хвороби, no. 1 (April 13, 2021): 13–17. http://dx.doi.org/10.11603/1681-2727.2021.1.11947.

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The purpose of the work is to carry out a comparative analysis of epidemiological, clinical and individual laboratory parameters of groups of patients with HIV infection associated with tuberculosis (TB) and TB monoinfection. Patients and methods. A comprehensive immunological examination was performed on 231 patients, including 155 HIV-infected with active newly diagnosed tuberculosis and 76 on tuberculosis alone. The HIV/TB group was divided into 3 subgroups depending on the time of TB accession to HIV infection. The levels of interleukin-4 (IL-4) and interferon-γ (IFN-γ) were compared for g

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Cai, Zhen, Xingkui Xue, Wenji Sun, and Hangping Yao. "Rerovirus Mediated HSV-TK Gene Transfer Can Influence the Function of Human T-Lymphocyte." Blood 106, no. 11 (2005): 5245. http://dx.doi.org/10.1182/blood.v106.11.5245.5245.

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Abstract To control graft-versus-host disease (GVHD) following allogeneic hematopoietic stem cell (HSC) transplantation while maintaining the graft antileukemic effects of donor T cells, a suicide gene encoding the herpes simplex virus thymidine kinase (HSV-TK) enzyme was introduced ex vivo via a retroviral vector into donor T cells. Although previous clinical trials showed that it was an efficient tool for controlling GVHD, the gene transduction process of donor T lymphocytes may influence the immunocompetence of the T cells. In the current study, we investigated the impact that the gene mani

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Gao, H., J. Ma, X. Wang, et al. "Preliminary study on the changes of ovarian reserve, menstruation, and lymphocyte subpopulation in systemic lupus erythematosus (SLE) patients of childbearing age." Lupus 27, no. 3 (2017): 445–53. http://dx.doi.org/10.1177/0961203317726378.

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Objective The main aim of this study was to investigate the ovarian reserve, menstruation, and lymphocyte subpopulation in systemic lupus erythematosus (SLE) patients of childbearing age. Methods We enrolled 40 SLE patients of childbearing age and 40 age-matched healthy controls. Anti-Müllerian hormone (AMH) was tested by electrochemiluminescence, and lymphocyte subsets were tested by flow cytometry. Menstruation situation was obtained by interview. Results The AMH level of the SLE group was significantly lower than that of the control group ( p < 0.001), which was negatively correlated wit

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Ambar, Nabil Salim, Aryati Aryati, Tutik Kusmiati, and Erwin Astha Triyono. "CORRELATION BETWEEN INTERFERON GAMMA RELEASE ASSAY OF ELISPOT METHOD AND CD4+ T LYMPHOCYTE CELL COUNT IN HIV POSITIVE PATIENTS." INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY 25, no. 3 (2019): 333. http://dx.doi.org/10.24293/ijcpml.v25i3.1416.

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Introduction. HIV is a virus that can cause AIDS, which affects the immune system and weakens the body function in fighting disease. The primary cells that HIV attacks are CD4+ T lymphocytes. Opportunistic Infections (OIs) are the biggest risk factors of death in HIV patients and occur in CD4+ T cells <200 cells/μL lymphocytes. TB is a disease with a high mortality rate in the world where Indonesia is a TB endemic country with the highest morbidity rates of TB in the world. The most common OI in people with HIV is TB. The number of limitations on Tuberculin Skin Test (TST) is large, thus in

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Piao, Chunnan, Mei Tian, Hongjun Gao, et al. "Effects of Radon From Hot Springs on Lymphocyte Subsets in Peripheral Blood." Dose-Response 18, no. 1 (2020): 155932582090233. http://dx.doi.org/10.1177/1559325820902338.

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Objective: To analyze changes in immune functions by detecting lymphocyte subsets in the peripheral blood of residents in the vicinity of radon from hot springs. Methods: Two groups were randomly selected; 61 residents in the vicinity of the hot springs were assigned to the radon group, and 51 residents with a similar lifestyle and habits but no contact with hot springs were assigned to the control group. The percentages of lymphocyte subsets (CD3+, CD4+CD8−, CD4−CD8+, CD4+/CD8+, and TCR/CD3) in the 2 groups were evaluated on a FACS Aria flow cytometer. The absolute values of lymphocytes (LYMP

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Nowicka, Danuta, Ewelina Grywalska, Agnieszka Grafka, Elżbieta Fitas, Agata Surdacka, and Jacek Roliński. "Disrupted Treg/Th17 balance in patients with recurrent furunculosis." Postępy Higieny i Medycyny Doświadczalnej 73 (January 7, 2019): 159–64. http://dx.doi.org/10.5604/01.3001.0013.1136.

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Aim: Tregs and Th17 functioning may be impaired in patients with recurrent furunculosis (RF); therefore, we analyzed changes in CD4+ lymphocyte T subsets (Treg/Th17) in patients with RF, and assessed the relationships between increased susceptibility to infections and Treg/Th17 status in RF patients and healthy subjects. Material/Methods: Peripheral blood samples from 30 patients with RF and 20 healthy age- and sex-matched subjects were examined. The percentage and number of Th17 cells, Tregs, and other basic lymphocyte subsets were examined. Results: Tregs and CD3+CD4+ count was significantly

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Losurdo, Giuseppe, Domenico Piscitelli, Federica Pezzuto, et al. "T Helper Lymphocyte and Mast Cell Immunohistochemical Pattern in Nonceliac Gluten Sensitivity." Gastroenterology Research and Practice 2017 (2017): 1–9. http://dx.doi.org/10.1155/2017/5023680.

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Background and Aims. Nonceliac gluten sensitivity (NCGS) is a gluten-related emerging condition. Since few data about NCGS histopathology is available, we assessed the markers of lymphocyte and innate immunity activation. Materials and Methods. We retrieved duodenal biopsy samples of patients with NCGS diagnosis according to the Salerno criteria. We selected specimens of positive (seropositive celiac disease/Marsh 1-2 stage) and negative (normal microscopic picture) controls. Immunohistochemistry for CD3 (intraepithelial lymphocytes-IELs), CD4 (T helper lymphocytes), CD8 (T cytotoxic lymphocyt

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