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Journal articles on the topic 'Lymphocytic dermal infiltration'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Mohaghegh, Fatemeh, Zohre Khodashenas, Mina Saber, and Haniyeh Sohrabi. "Syringotropic Lichen Planus: An Unusual Presentation of a Common Dermatosis – A Report of 2 Cases." Case Reports in Dermatology 16, no. 1 (2024): 226–33. http://dx.doi.org/10.1159/000541695.

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Introduction: Lichen planus (LP) is a chronic inflammatory dermatosis that causes plaques and itchy papules on the skin, as well as erosion and ulcers in the mucous membranes. LP is characterized by a dense dermal T-cell infiltration. Perieccrine inflammation can be seen in a variety of dermatoses, but genuine lymphocyte permeation of the secretory coil or lymphocytic syringotropism is a rare sign that is typically seen in mycosis fungoides. Case Presentation: In this study, we present 2 uncommon instances of lymphocytic syringotropism in LP. Histopathological examination revealed dense T-cell

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Sugioka, Kyoko, Akinobu Hayashi, Masako Ichishi, Yasuko Sugimoto, Koji Habe, and Keiichi Yamanaka. "Three Cases of Lymphocytic Infiltration of the Eyelid." Dermatopathology 8, no. 2 (2021): 124–29. http://dx.doi.org/10.3390/dermatopathology8020018.

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Lymphocytic infiltration of the skin (LIS), first reported by Jessner and Kanof in 1953, is a disease of unknown etiology characterized by erythematous papules and plaques on the head, neck, and upper back and histopathological findings of a normal epidermis with underlying lymphocytic infiltration of the reticular dermis without mucin deposition. A 69-year-old man and a 21-year-old woman presented with edematous indurative erythema of the left upper eyelid. Lymphocytic infiltration of the dermis with CD4+ T cell predominance was noted on biopsy. A 68-year-old man presented with a four-year hi

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3

BARKER, J. N. W. N., J. OPHIR, and D. M. MACDONALD. "Keratinocyte HLA-DR expression: the relationship to dermal lymphocytic infiltration." Clinical and Experimental Dermatology 12, no. 6 (1987): 397–99. http://dx.doi.org/10.1111/j.1365-2230.1987.tb01934.x.

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4

Ghanadan, Alireza, Zahra Naraghi, Kambiz Kamyab Hesari, et al. "Histopathologic interpersonal overview of generalized pustular cutaneous reaction to Hydroxychloroquine (HCQ): New challenging clinical manifestation." Pakistan Journal of Medical and Health Sciences 15, no. 6 (2021): 2102–6. http://dx.doi.org/10.53350/pjmhs211562102.

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Background: Pathologic examination of Acute Generalized Exanthematous Pustulosis (AGEP) and Pustular Psoriasis (PP) are similar. We encountered many patients with PP or AGEP who cannot be distinguished clinically, pathologically and based on disease course from each so we designed a comprehensive interpersonal histopathologic overview of these patients' samples. Method: Histopathological data of 16 patients over 3.5 years were analyzed. Four pathologists separately reviewed specimens based on eighteen criteria (9 Epidermal and 9 Dermal). Severity score for each criterion was considered as to b

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SARIDOMICHELAKIS (Μ. Ν. ΣΑΡΙΔΟΜΙΧΕΛΑΚΗΣ), M. N., C. K. KOUTINAS (X.K. ΚΟΥΤΙΝΑΣ), and A. F. KOUTINAS (Α. Φ. ΚΟΥΤΙΝΑΣ). "A case of canine epitheliotropic lymphoma (mycosis fungoides)." Journal of the Hellenic Veterinary Medical Society 52, no. 4 (2018): 286. http://dx.doi.org/10.12681/jhvms.15459.

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The clinical picture, diagnosis and treatment of a dog with epitheliotropic lymphoma are presented. The dog (male, mongrel, 13-year old) was admitted to our Clinic with a 5-month history of non-pruritic skin lesions. At clinical examination a multifocal to diffuse exfoliative erythrodermia was the most striking finding. Diagnosis of epitheliotropic lymphoma was based on cutaneous histopathology, revealing a dense dermal and epidermal lymphocytic infiltration and Pautrie microabcess formation. Initial treatment with isotretinoin had a poor impact on skin lesions that progressed to the macular s

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Shah, Urvi H., Monal M. Jadwani, Sahana P. Raju, Pranav H. Ladani, and Neela V. Bhuptani. "Clinical and histopathological features in lepra reaction: a study of 50 cases." International Journal of Research in Dermatology 5, no. 2 (2019): 382. http://dx.doi.org/10.18203/issn.2455-4529.intjresdermatol20191766.

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<p class="abstract"><strong>Background:</strong> Lepra reactions remain a major persistent problem in leprosy. Type 1 and type 2 (erythema nodosum leprosum-ENL) reactions are the major causes of nerve damage and permanent disabilities. Diagnosing lepra reactions correctly is important for timely institution of therapy to prevent and treat disability and morbidity. Aim and objectives<strong> </strong>of the study were<em> </em>to make detailed observations on clinical and histopathological features of type1 and type 2 lepra reactions.</p><p cla

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Batinac, Tanja, Gordana Zamolo, Nives Jonjić, et al. "Angioimmunoblastic Lymphadenopathy with Dysproteinemia following Doxycycline Administration." Tumori Journal 89, no. 1 (2003): 91–95. http://dx.doi.org/10.1177/030089160308900120.

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Angioimmunoblastic lymphadenopathy with dysproteinemia (AILD) is a primary lymphoproliferative T-cell disorder, currently classified as a peripheral T-cell non-Hodgkin's lymphoma. AILD is characterized by generalized lymphadenopathy, hepatosplenomegaly, immunological abnormalities, polyclonal hypergammaglobulinemia and anemia. We report a case of AILD in an 80-year-old male who presented with a generalized pruritic maculopapular eruption and fever following doxycycline administration. The maculopapular rash progressed to formation of confluent nodules, plaques and finally erythroderma with lym

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Corona, R., A. Mele, M. Amini, et al. "Interobserver variability on the histopathologic diagnosis of cutaneous melanoma and other pigmented skin lesions." Journal of Clinical Oncology 14, no. 4 (1996): 1218–23. http://dx.doi.org/10.1200/jco.1996.14.4.1218.

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PURPOSE To assess the interobserver agreement on the diagnosis and classification of cutaneous melanoma. MATERIALS AND METHODS A set of 140 slides of cutaneous melanoma, including a small subset of benign pigmented skin lesions, were circulated to four experienced histopathologists. The kappa statistic for multiple ratings per subject was calculated using the method described by Fleiss. RESULTS The kappa value on the diagnosis of cutaneous melanoma versus benign lesions was 0.61. There was some discordance on the diagnosis in 37 of 140 cases (26%). For the histopathologic classification of cut

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Janovska, Jana, Aleksejs Zavorins, Julija Voicehovska, et al. "SKIN CHANGES AND PECULIARITIES IN PATIENTS WITH METABOLIC SYNDROME." CBU International Conference Proceedings 1 (June 30, 2013): 264–71. http://dx.doi.org/10.12955/cbup.v1.43.

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Approximately 20-25 % of the World’s adult population aged 40 - 75 years have metabolic syndrome (MS). MS is one of the most widespread risk factors for: diabetes mellitus, cardiovascular disorders and skin disorders MS, due to the oxidative stress, supports a chronic inflammatory reaction in the skin and in the other parts of the body. During oxidative stress the net amount of reactive oxygen species (ROS) exceeds the antioxidant capacity of the body causing lipid peroxidation, protein oxidation and oxidative DNA damage. The role of oxidative stress in pathogenesis of early skin changes in pa

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10

Yanto, Theo Audi, Nathania Raphaeli Mulia, Abraham Fatah, and Nana Novia Jayadi. "Pityriasis Lichenoides et Varioliformis Acuta pada Wanita Dewasa dengan Bakteriuria Asimptomatik: Sebuah Pemicu Lain?" Journal Of The Indonesian Medical Association 73, no. 1 (2023): 39–45. http://dx.doi.org/10.47830/jinma-vol.73.1-2023-642.

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Introduction: Pityriasis Lichenoides et Varioliformis Acute (PLEVA) is a rare and benign inflammatory skin disease. This acute form is distinguished from the milder chronic condition, Pityriasis Lichenoides Chronica (PLC). The etiology of PLEVA itself remains unclear, although it has been associated with infection as a trigger.Case: Here, we present the case of a 34-year-old woman who presented with abrupt, generalized, pruritic skin eruptions for two months.Case Discussion: The eruptions started as red scaly papules and vesicles and resolved as hyperpigmentations. She denied having any previo

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Wang, X., G. Diercks, W. Lambers, et al. "OP0308 SENESCENT PROGENITOR CELLS IN THE SKIN OF LUPUS PATIENTS." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 189.1–189. http://dx.doi.org/10.1136/annrheumdis-2021-eular.1105.

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Background:Systemic lupus erythematosus (SLE) is an autoimmune disease, which is characterized by skin lesions, amongst other symptoms. These lesions (chronic discoid lupus erythematosus (CDLE) and subacute cutaneous lupus erythematosus (SCLE)) feature lymphocytic infiltration close to basal layer of the epidermis (i.e. the location of the epidermal progenitor cells), namely the epidermal dermal junction (EDJ) area. Epidermal progenitor cells maintain the homeostasis of the skin through their proliferation and differentiation into keratinocytes. In fast turnover tissues, like the skin, a popul

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Li, Ronghui, Liping Peng, Jian Zhang, Hanqing Zeng, Zuojun Li, and Chunjiang Wang. "Clinical Features, Diagnosis, Treatment, and Prognosis of Heparin-Induced Bullous Hemorrhagic Dermatosis." Dermatologic Therapy 2024 (March 4, 2024): 1–6. http://dx.doi.org/10.1155/2024/1372188.

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Background. Heparin-induced bullous hemorrhagic dermatosis (HBHD) is a rare cutaneous adverse effect of heparin and has unclear clinical features. We explored the clinical features of HBHD to provide evidence for the safe use of heparin. Methods. We collected HBHD-related case reports for a retrospective analysis by searching the Chinese and English databases from inception to December 31, 2022. Results. Seventy-two patients, including 51 males (70.8%), were included, and they had a median age of 71.5 years (range: 21, 94). Low-molecular-weight heparin was used in 62 patients (86.1%), and unfr

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Omran, Ahmed M., Sherif H. Youssif, Ibrahim Fouda, Khaled Maher Muhammad Elagamy, Mahmoud abdelhamid Elhendawy, and Saber M. Abdelmaksoud. "Epidermal Verrucal Lesion with Velvety-Like Granular Surface at Female External Genitalia and Medial Aspect of the Thigh Compatible with Previous History of Longstanding Psoriasis : A Case Report." Scientific Journal of Medical Scholar, no. 4 (July 15, 2020): 103–5. http://dx.doi.org/10.55675/sjms.v2020i4.83.

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Psoriasiform dermatoses are a wide spectrum of inflammatory diseases, with several major forms represented by different clinical entities. Psoriasis is the prototype of psoriasiform dermatoses. Other conditions include pustular psoriasis, Reiter’s syndrome, pityriasis rubra pilaris, lichen simplex chronicus and large-plaques parapsoriasis. These lesions represent a diagnostic challenge, both on clinical and histopathological basis. This could be attributed to overlapping clinical and histopathological features. All of them share the hyperactivity of keratinocytes leading to extensive hyperkera

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Khaleefah, Isam Azeez, Hassan M. Al-Tameemi, Qayssar Ali Kraidi, Harith Abdulla Najem, Jihad Abdulameer Ahmed, and Haider Rasheed Alrafas. "Clinical and molecular detection of fowl pox in domestic pigeons in Basrah Southern of Iraq." Korean Journal of Veterinary Research 64, no. 1 (2024): e7. http://dx.doi.org/10.14405/kjvr.20230048.

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Bird species, particularly poultry and other bird types, including domestic pigeons, are susceptible to fowl pox, a contagious viral disease. The main goal of this study was to validate clinical avipoxvirus diagnoses using molecular analytical methods. The essential components of the investigation were the clinical signs, visible abnormalities, histological changes, and polymerase chain reaction analysis. Twenty out of 120 pigeons had clinical symptoms, which included yellowish crust or nodules near the feet, eyes, and beak. An erosive epidermal lesion and an epidermal acanthotic papular lesio

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15

Kuo, Tseng-long, Sing-Kai Lo, and Heng-Leong Chan. "Immunohistochemical analysis of dermal mononuclear cell infiltrates in cutaneous lupus erythematosus, polymorphous light eruption, lymphocytic infiltration of Jessner, and cutaneous lymphoid hyperplasia:. A comparative differential study." Journal of Cutaneous Pathology 21, no. 5 (1994): 430–36. http://dx.doi.org/10.1111/j.1600-0560.1994.tb00285.x.

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Guleva, D., M. Balabanova, L. Miteva, and L. Dourmishev. "Histology of Skin Alterations in Lupus Erythematosus." Acta Medica Bulgarica 49, no. 2 (2022): 28–32. http://dx.doi.org/10.2478/amb-2022-0016.

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Abstract Lupus erythematosus is an autoimmune connective tissue disorder showing a broad spectrum of clinical manifestations. The aim of this study was to assess the correlation of skin histology and different types of lupus erythematosus. Materials and methods: Fifty-one skin specimens were assessed from 39 female and 12 male patients with acute, subcutaneous and chronic lupus erythematosus, diagnosed and treated in the Department of Dermatology and Venereology, Alexandrovska University Hospital for a 4-year period. Results: Follicular hyperkeratosis, epidermal atrophy, vacuolar degeneration

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Khalil, Eltahir Awad Gasim, B. M. Younis, W. S. E. Seed, M. A. Magzoub, A. M. Elhassan, and A. M. Musa. "Liposomal amphotericin B (AmBisome®) pharmacokinetics: Reaching the skin, review of the literature, and a case series of treated severe disfiguring post kala-azar dermal leishmaniasis." Annals of Medical Science & Research 4, Suppl 1 (2025): S109—S114. https://doi.org/10.4103/amsr.amsr_56_24.

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Abstract Post kala-azar dermal leishmaniasis (PKDL) that usually follows successfully treated visceral leishmaniasis (VL) can be severe and disfiguring. Treatment with sodium stibogluconate is prolonged, expensive with colossal cardiorenal toxicities. Early trials with liposomal amphotericin B (AMB) (AmBisome®) revolutionized PKDL treatment with increased safety and improved efficacy. AmBisome® pharmacokinetics and dynamics are poorly understood. This study aimed to show the efficacy of AmBisome® through its permeation within skin lesions. Following guardians’ written consent, ten PKDL patient

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Lemery, Steven J., Kenneth F. More, Neal S. Young, and Elaine M. Sloand. "Daclizumab-Associated Erythroderma Is Associated with Rebound Increases in CD25-Positive CD4 Cells Following Treatment of Aplastic Anemia and Pure Red Cell Aplasia." Blood 106, no. 11 (2005): 1042. http://dx.doi.org/10.1182/blood.v106.11.1042.1042.

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Abstract We previously have reported success in treating patients with moderate aplastic anemia with daclizumab, a humanized monoclonal antibody that recognizes the interleukin-2 receptor (Blood.2003; 102(10):3584–6). Since our first report we have treated eighty-eight patients with moderate aplastic anemia, pure red cell aplasia and relapsed severe aplastic anemia with 1 mg/kg of monoclonal antibody every 2 weeks for 3 months. Although this drug has been used extensively in the management of solid organ rejection, erythroderma has not been reported. In our study, five patients developed a sev

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BOPPANA, D. K. V., S. K. WIKEL, D. G. RAJ, M. B. MANOHAR, and J. LALITHA. "Cellular infiltration at skin lesions and draining lymph nodes of sheep infested with adultHyalomma anatolicum anatolicumticks." Parasitology 131, no. 5 (2005): 657–67. http://dx.doi.org/10.1017/s0031182005008243.

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Immunohistochemical analysis of skin and draining lymph nodes of sheep repeatedly infested with the ixodid tickHyalomma anatolicum anatolicumwere studied for different antigen-presenting cells and lymphocyte subpopulations. Infiltration of neutrophils, macrophages and lymphocytes adjacent to the tick bite site were observed. Skin biopsies showed significant increases in dermal infiltration of CD8+and γδ+T cells at 72 h and 8 days after both primary and secondary infestation. Infiltrations of MHC-II DR/DQ decreased at 72 h after tick infestation, whereas significant increases were recorded for

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Nallathamby, Kasthuri, Kat Moss, Richard Azurdia, and Nitin Khirwadkar. "P010 Eosinophilic dermatosis of haematological malignancy mimicking insect bite-like reaction in a patient with chronic lymphocytic leukaemia: a case report." British Journal of Dermatology 191, Supplement_1 (2024): i19. http://dx.doi.org/10.1093/bjd/ljae090.037.

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Abstract We present a case of a patient presenting with severe insect bite-like reactions in her skin with underlying chronic lymphocytic leukaemia (CLL). A 71-year-old woman was diagnosed with CLL in 2017 after presenting with a low-level lymphocytosis. She has never required treatment for CLL and remains under active observation in the haematology clinic. She was initially referred to dermatology 5 years ago with a nonresolving insect bite-like rash on her chest. The biopsy of the lesion was thought to be reactive with CLL infiltration. Over the years she has had a number of flare-ups of dif

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Bala, Laksha, Christie Tsang, Vani Agarwal, and Noha Elshimy. "P103 Clinical clues for frontal fibrosing alopecia: a case series describing prominent, depressed forehead veins." British Journal of Dermatology 191, Supplement_1 (2024): i64—i65. http://dx.doi.org/10.1093/bjd/ljae090.130.

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Abstract Frontal fibrosing alopecia (FFA) is a lymphocytic, scarring alopecia characterized by progressive frontotemporal hairline recession, most frequently in postmenopausal women. It is considered a subtype of lichen planopilaris, given the shared histopathological findings of perifollicular lymphocytic infiltration and fibrosis. FFA is a recently reported entity and one of the most common causes of cicatricial alopecia worldwide. Its pathogenesis is not well understood, with immune dysregulation, and hormonal, genetic and environmental factors all postulated to play a role. Clinical featur

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Al Shabbani, Nada Hamzah Shareef, Marwa Jamal Hussain Al Kinani, and Tmara Qais Al-mohammadi. "Gross and Histopathological Study of Postscabietic Nodules." European Journal of Medical Genetics and Clinical Biology 1, no. 5 (2024): 130–37. http://dx.doi.org/10.61796/jmgcb.v1i5.454.

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Background: Nodular postscabietic scabies refer to the persistent intermittent signs of scabies that are seen in active and post-treatment period that might last for months. The spectrum of clinico-morphological ranges that can be observed with sarcoptic nodules is broad, and most of the entity's criteria can be elicited histopathologically and pathologically. The management of such nodules may be a challenge. They are commonly treated through local application of corticosteroids or injection of corticosteroids to nodules but the response to treatment is less than clent and relapses are very f

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Jonczyk, Michael, Ilse M. Schol, Philipp Tratnig-Frankl, Alexandre G. Lellouch, Dicken S. C. Ko, and Curtis L. Cetrulo. "3281 Management of Acute Rejection in Penile Allotransplantation." Journal of Clinical and Translational Science 3, s1 (2019): 15–16. http://dx.doi.org/10.1017/cts.2019.38.

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OBJECTIVES/SPECIFIC AIMS: Objective: To summarize the diagnosis and management of two acute rejection (AR) episodes in the first penis transplant patient in the U.S. Background: Vascularized composite allotransplantation (VCA) has been utilized for state-of-the-art reconstruction of devastating craniofacial defects, limb loss, and recently, severe genitourinary defects. To date, more than 200 VCA’s have been performed, of which four successful penis transplants have been achieved worldwide (Two in the U.S.). However, despite the technical success of VCAs in general, acute rejection episodes re

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Rutter, Kirsty, Michael Peake, Nathan Hawkshaw, et al. "PD07 Transcriptomic study of lesion evolution in photoaggravated atopic dermatitis indicates early involvement of innate immunity, T helper (Th)1 and Th22 responses, and a predominant Th2 signature." British Journal of Dermatology 191, Supplement_1 (2024): i84. http://dx.doi.org/10.1093/bjd/ljae090.171.

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Abstract Photoaggravated atopic dermatitis (PAD) is a subtype of atopic dermatitis (AD) that is exacerbated or provoked by exposure to ultraviolet radiation. However, its early pathomechanisms are poorly understood. Our aims were (i) to investigate cutaneous clinical, barrier, cellular and molecular changes in the evolution of PAD following low-dose solar simulated ultraviolet radiation (SSR) exposure, and (ii) to compare the findings in healthy controls exposed to the same SSR challenge. Three consecutive daily low-dose (10 J cm−2) SSR exposures were delivered to upper buttock skin of six pat

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Tohya, Kazuo, Shiori Urabe, Jun Igarashi, Taro Tomura, Akemi Take, and Michio Kimura. "Appearance of Peculiar Vessels with Immunohistological Features of High Endothelial Venules in the Dermis of Moxibustion-Stimulated Rat Skin." American Journal of Chinese Medicine 28, no. 03n04 (2000): 425–33. http://dx.doi.org/10.1142/s0192415x00000507.

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Morphological changes of the dermal blood vessels of moxibustion-stimulated rat skin were examined with reference to the lymphocyte migration. After long-term stimulation with direct moxibustion to the acupoint Tsu-San-Li (St-36), peculiar vessels that possess immunohistological features of high endothelial venules could be observed in the moxa-stimulated acupoint dermis. Endothelial cells of the vessels had well-developed Golgi apparatus in their plump cytoplasms, and they strongly expressed intercellular adhesion molecule-l on the luminal surface. These data suggest that the appearance of th

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Okada, K., A. Yamaguchi, K. Ohshima, et al. "Spontaneous Regression of Bovine Cutaneous Leukosis." Veterinary Pathology 26, no. 2 (1989): 136–43. http://dx.doi.org/10.1177/030098588902600206.

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Biopsies of skin from a 2-year-old heifer with spontaneously regressing dermal leukosis were examined. The heifer was not infected with bovine leukemia virus and was negative for tumor-associated antigens of enzootic bovine lymphosarcoma. By hematological standards for bovine leukemia, the heifer was positive at about 60 days post-occurrence of the disease (POD). At 53 days POD, lymphoblastic neoplastic cells in the dermis reacted with anti-T lymphocyte monoclonal antibody by the avidin biotin peroxidase complex method. The cells had intracytoplasmic clustered dense bodies under electron micro

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Cho, Jun Young, Han Gyu Cha, Eun Soo Park, Chang Yong Choi, Seung Min Nam, and Hee Kyung Kim. "Development of Cutaneous Pseudolymphoma following Bee Sting: A Case Report." Journal of Wound Management and Research 20, no. 2 (2024): 189–93. http://dx.doi.org/10.22467/jwmr.2024.02929.

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Cutaneous pseudolymphoma (CPL) is a benign skin disorder characterized by the presence of a lymphocyte-rich infiltrate resembling malignant lymphoma. As there are significant differences in management and clinical outcomes, differentiating CPL from true lymphomas is crucial. The diagnostic process involves a comprehensive approach, incorporating clinical examination, histopathological analysis, and when necessary, immunohistochemical staining to distinguish CPL from true lymphomas. Biopsy plays a key role in assessing characteristics of infiltrating lymphocytes and architectural arrangements o

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Joh, Christine, Soyoung Jeong, Jung Ho Lee, et al. "Spatial Transcriptomic Profiling Reveals the Pathophysiology of Early Stage Hidradenitis Suppurativa." Journal of Immunology 210, no. 1_Supplement (2023): 63.07. http://dx.doi.org/10.4049/jimmunol.210.supp.63.07.

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Abstract Hidradenitis suppurativa (HS) is a chronic inflammatory skin disorder that ranges from superficial nodules and deep abscesses to draining dermal tunnels in the intertriginous regions. It causes significant pain, scarring, and a poor quality of life, yet there are currently no effective treatment options. The role of tunnels or sinus tracts—a unique feature of moderate to severe HS—was reported that the epidermal tunnels are the source of inflammatory mediators in Hurley stages II and III. However, the pathophysiology of early stage HS needs further investigation. Here, we examined the

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Visconte, Valeria, Heesun J. Rogers, Ali Tabarroki, et al. "SF3B1, a Splicing Factor Gene, Is Infrequently Mutated in Rare Bone Marrow Failure Diseases but Still Associated with Ring Sideroblast Phenotype." Blood 120, no. 21 (2012): 3485. http://dx.doi.org/10.1182/blood.v120.21.3485.3485.

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Abstract Abstract 3485 Bone marrow failure syndromes (BMFS) are clonal diseases characterized by inefficient hematopoiesis leading to cytopenias. The clinical and biological heterogeneity often complicates therapy. A number of biological/genetic causes determine the pathogenesis of BMFS (immunological factors, cytokine, telomeres length, T-cell repertoire, epigenetic, apoptotic dysregulation, and chromosomal instability). Whole exome/genome sequencing identified novel mutations in myeloid disorders. SF3B1, a splicing factor gene is mutated primarily in myelodysplastic syndromes (MDS) with ring

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Snider, Theron G., Phillip H. Klesius, and T. Barry Haynes. "Dermal responses to Ostertagia ostertagi in Ostertagia ostertagi- and Cooperia punctata-inoculated calves." American Journal of Veterinary Research 46, no. 4 (1985): 887–90. https://doi.org/10.2460/ajvr.1985.46.04.887.

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SUMMARY Calves harboring patent Ostertagia ostertagi or Cooperia punctata were given intradermal injections of O ostertagi 3rd-stage larval antigen. The initial injections were followed 30 days later by a 2nd series of injections. Skin thickness was measured at injection sites for 72 hours after injection. Selected injection sites including saline solution control sites were biopsied at 30 minutes, at 3, 24, 48, and 72 hours, and at 30 days after injection. After the 1st series of injections, there was a clear distinction in dermal reactions between O ostertagi-inoculated calves and C punctata

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Melkonyan, K. I., A. A. Verevkin, A. S. Sotnichenko, et al. "Morphological analysis of a local tissue response to subcutaneously implanted acellular dermal matrix fragments." Bulletin of Siberian Medicine 21, no. 2 (2022): 97–104. http://dx.doi.org/10.20538/1682-0363-2022-2-97-104.

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Acellular dermal matrices (ADMs) are gaining popularity as surgical materials for operations on the pelvic organs, as well as in burn therapy and plastic surgery. Evaluation of the biocompatibility of surgical materials is an important and necessary step in the development of new ADMs.The aim of the study was to compare the results of subcutaneous implantation of ADM and native porcine skin in rats.Materials and methods. To obtain ADMs, detergent – enzymatic decellularization was used. On days 7, 14, 21, and 60 after the implantation of ADMs (the experimental group) and native porcine skin (th

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Klareskog, L., A. Scheynius, and U. Tjernlund. "Distribution of interleukin-2 receptor bearing lymphocytes in the skin. A comparative study of allergic and irritant contact dermatitis, tuberculin reaction and cutaneous T cell lymphoma." Acta Dermato-Venereologica 66, no. 3 (1986): 193–99. http://dx.doi.org/10.2340/0001555566193199.

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The tissue distribution of T cells and interleukin-2 receptor bearing (Tac+) lymphocytes was studied immunohistochemically in frozen sections of biopsies from inflamed skin. In skin lesions caused by irritant or immunologic stimuli, relatively few (less than 5%) of the total dermal infiltrating T cells were Tac+, but in both types of conditions the Tac+ cells showed a predeliction for the epidermis. In skin lesions from patients with cutaneous T cell lymphoma a relatively high proportion of dermal T lymphocytes were Tac+. Tac+ as well as Tac- T lymphocytes may thus migrate to a tissue secondar

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A, Bajaj. "The Pervasive Forager-Solitary Reticulohistiocytoma." Cytology & Histology International Journal 5, no. 1 (2021): 1–5. http://dx.doi.org/10.23880/chij-16000128.

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Solitary reticulohistiocytoma is an exceptional, benign, non-neoplastic, non-Langerhans histiocytic cell proliferation. The condition appears as a cytokine-induced, localized collection of histiocytic cells emerging as a reaction to an obscure inflammatory stimulus. Reticulohistiocytic lesions are subcategorized into distinct categories as solitary cutaneous reticulohistiocytoma, multiple cutaneous reticulohistiocytoma and multi-centric reticulohistiocytosis. Solitary reticulohistiocytoma appears as an isolated, painless nodule at diverse sites and is devoid of systemic symptoms. A diffuse, de

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Ansari, Rehan, Elva Nora Osuna Salazar, Nabeel Sarhill, Laura E. Garcia, and James Hanley. "All Itching Is Not Benign; A Case of Refractory Hypereosinophilic Syndrome Treated with Off Label CD52 Inhibitor-Alemtuzumab." Blood 132, Supplement 1 (2018): 5485. http://dx.doi.org/10.1182/blood-2018-99-118271.

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Abstract INTRODUCTION Usually attributed to allergies or parasites (Seifert et. al Medline 2008) eosinophila is often overlooked. However hypereosinophilia (absolute eosinophil count >1.5 X 109/L on two separate exams one month apart or with pathologic confirmation) can have serious manifestations. When hypereosinophilia is associated with eosinophil-mediated organ damage or dysfunction, a hypereosinophilic syndrome (HES) exists. With an unpredictable course, eosinophilic infiltration commonly affects the skin (eczema), lung (dyspnea), & GIT (gastritis). However life-threatening damage

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Jacobs, Nathalie, Ron A. J. Chen, Caroline Gubser, Pilar Najarro, and Geoffrey L. Smith. "Intradermal immune response after infection with Vaccinia virus." Journal of General Virology 87, no. 5 (2006): 1157–61. http://dx.doi.org/10.1099/vir.0.81556-0.

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Although Vaccinia virus (VACV) was used to eradicate smallpox by dermal vaccination, there is little information available about the immune response induced at the vaccination site. Previously, an intradermal murine model that mimics smallpox vaccination was established. Here, this model was used to investigate which leukocytes are recruited to the infected lesion and what are the kinetics of recruitment. Data presented show that VACV infection induced the infiltration of macrophages, followed by granulocytes and lymphocytes. Up to 4 days post-infection, the major lymphocyte population was TCR

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Ohmann, H. Bielefeldt. "In Situ Characterization of Mononuclear Leukocytes in Skin and Digestive Tract of Persistently Bovine Viral Diarrhea Virus-infected Clinically Healthy Calves and Calves with Mucosal Disease." Veterinary Pathology 25, no. 4 (1988): 304–9. http://dx.doi.org/10.1177/030098588802500409.

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The phenotypic identity of mononuclear leukocytes in skin and digestive tract of bovine viral diarrhea virus (BVDV)-infected animals was examined using sensitive single and double labeling immunocyto-chemical techniques. Occurrence and distribution of B lymphocytes, T lymphocytes of either the helper (BoT4) or suppressor/cytotoxic (BoT8) subsets, and macrophages (M⊘) were examined. No differences were found in the skin and digestive tract of persistently infected clinically healthy calves and uninfected controls, despite widespread virus-antigen presence in keratinocytes (stratum basale and st

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Frew, A. J., and A. B. Kay. "The relationship between infiltrating CD4+ lymphocytes, activated eosinophils, and the magnitude of the allergen-induced late phase cutaneous reaction in man." Journal of Immunology 141, no. 12 (1988): 4158–64. http://dx.doi.org/10.4049/jimmunol.141.12.4158.

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Abstract The phenotype and activation status of leukocytes infiltrating human late phase allergic skin reactions were investigated by immunocytochemistry using a panel of mAb. Late phase skin reactions were induced in atopic individuals by intradermal challenge with allergen extract (grass pollen or house dust mite) and skin biopsies were obtained 6, 24, or 48 h after challenge. Cryostat sections were examined for evidence of infiltration and activation of T cells and eosinophils. Biopsies from saline-challenged control sites were used for comparison. A substantial number of CD3+ cells were ob

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Youkhana, S. O. "Dermatitis in sheep in Mosul area." Al-Qadisiyah Journal of Veterinary Medicine Sciences 9, no. 2 (2010): 6. http://dx.doi.org/10.29079/vol9iss2art98.

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Dermatitis in (25) sheep showing the different distribution of the lesions was classified pathologically to acute, subacute, and chronic dermatitis. Grossly, the lesions were characterized by alopecia, erythema, exudation, ulceration, scale and crust formation. Histopathological sections revealed degeneration, spongiosis, intercellular edema with diffuse leukocytic infiltration predominantly neutrophils, lymphocytes and eosinophils in the dermal layer of the skin. The lesions were more progressive in chronic dermatitis.

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Goteri, Gaia, Alessandra Filosa, Serena Rupoli, et al. "Dendritic Cells and CD8+ Lymphocytes in Early Mycosis Fungoides." Blood 104, no. 11 (2004): 4556. http://dx.doi.org/10.1182/blood.v104.11.4556.4556.

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Abstract Dendritic cells (DCs) are immune accessory cells involved in the uptake, processing and presentation of antigens to reactive T cells. In Mycosis fungoides (MF), they are increased when compared to healthy skin, although their role has not yet been elucidated. The activation of the so called TILs (tumor infiltrating lymhocytes) is more efficient when DCs have completed their maturational process. Therefore, blockage of DCs maturation by MF neoplastic cells could represent a mechanism of tumoral escape. The distribution and the density of DCs expressing CD207 (the langerin molecule) and

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Riski Bagus Suhendra, Diah Prabawati Retnani, and Anggun Putri Yuniaswan. "Histopathological features of reversal reactions in Morbus Hansen." World Journal of Advanced Research and Reviews 23, no. 1 (2024): 2435–42. http://dx.doi.org/10.30574/wjarr.2024.23.1.1194.

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The reversal reaction on Morbus Hansen is a type IV hypersensitivity reaction to M. leprae antigens. The clinical symptoms of a reversal reaction are that some or all of the existing lesions become more numerous and active in a short time. Hypopigmented lesions become more erythematous, erythematous lesions become increasingly erythematous, macular lesions become infiltrating, and old lesions increase in size. The histopathological feature of the reversal reaction showing dermal edema, stretching of the granulomas followed by loss of the well form granuloma arrangement, and predominance of lym

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Riski, Bagus Suhendra, Prabawati Retnani Diah, and Putri Yuniaswan Anggun. "Histopathological features of reversal reactions in Morbus Hansen." World Journal of Advanced Research and Reviews 23, no. 1 (2024): 2435–42. https://doi.org/10.5281/zenodo.14811124.

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The reversal reaction on Morbus Hansen is a type IV hypersensitivity reaction to <em>M. leprae</em> antigens. The clinical symptoms of a reversal reaction are that some or all of the existing lesions become more numerous and active in a short time. Hypopigmented lesions become more erythematous, erythematous lesions become increasingly erythematous, macular lesions become infiltrating, and old lesions increase in size. The histopathological feature of the reversal reaction showing dermal edema, stretching of the granulomas followed by loss of the well form granuloma arrangement, and predo

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Srinivas, G., D.V. Ramanjaneyulu, E. Muralinath, et al. "An Essential Parameters of Parvo Virus Include Patho Physiology, Histo Pathology, Diagnosis, Differential Diagnosis, Treatment and Prognosis." Journal of Research and Reviews in Nursing Science and Education 2, no. 2 (2025): 11–17. https://doi.org/10.5281/zenodo.15541791.

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<em>One virus that only affects people is parvovirus B19. The fifth illness, also known as erythema infectious or slapped cheek syndrome, is known to be caused by it. It primarily affects young children, though it can sometimes affect adults. In addition, it may result in Poly arthropathy, popular-purpuric gloves and socks syndrome (PPGSS) in young people, certain anemias, hydrops fetalis, particularly in pregnant women, and an aplastic crisis. Viral transmission occurs through both respiratory secretions and blood products. The virus can infect a pregnant woman and then infect her unborn chil

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Sjölin-Forsberg, G., B. Berne, T. A. Eggelte, and A. Karlsson-Parra. "In situ localization of chloroquine and immunohistological studies in UVB-irradiated skin of photosensitive patients." Acta Dermato-Venereologica 75, no. 3 (1995): 228–31. http://dx.doi.org/10.2340/0001555575228231.

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Chloroquine can prevent photosensitivity reactions, but its mechanism of action is poorly understood. To investigate if the drug may interfere with inflammatory or immunological mechanisms of the UV-induced erythema of photosensitive patients, we studied the localization of chloroquine in the skin and its effect on the epidermal/dermal expression of IL-1, TNF-alpha, IL-6 and ICAM-1 and the occurrence of different lymphoid cells in normal skin and UVB-induced erythema in 8 patients with photosensitive discoid and systemic lupus erythematosus and 4 patients with polymorphic light eruption (PMLE)

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Tran, Christine A., Kevin T. Lynch, Max O. Meneveau, Priya Katyal, Walter C. Olson та Craig L. Slingluff,. "Intratumoral IFN-γ or topical TLR7 agonist promotes infiltration of melanoma metastases by T lymphocytes expanded in the blood after cancer vaccine". Journal for ImmunoTherapy of Cancer 11, № 2 (2023): e005952. http://dx.doi.org/10.1136/jitc-2022-005952.

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BackgroundImmune-mediated melanoma regression relies on melanoma-reactive T cells infiltrating tumor. Cancer vaccines increase circulating melanoma-reactive T cells, but little is known about vaccine-induced circulating lymphocytes (viCLs) homing to tumor or whether interventions are needed to enhance infiltration. We hypothesized that viCLs infiltrate melanoma metastases, and intratumoral interferon (IFN)-γ or Toll-like receptor 7 (TLR7) agonism enhances infiltration.MethodsPatients on two clinical trials (Mel51 (NCT00977145), Mel53 (NCT01264731)) received vaccines containing 12 class I major

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Englert, Karolina A., Grzegorz Dyduch, Agata Kłosowicz, et al. "Cutaneous Toll-like Receptor 9 Pre-Defines Hydroxychloroquine Dosage in Patients with Both Discoid and Subacute Lupus Erythematosus." Medicina 59, no. 11 (2023): 2022. http://dx.doi.org/10.3390/medicina59112022.

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Background and Objectives: Cutaneous lupus erythematosus (CLE) presents clinically heterogeneous manifestations, partially explained by the different expression of Toll-like receptors (TLRs) type 8 and 9, located to endosomal compartments where they are poised to recognize microbial nucleic acids. This disease is empirically treated with hydroxychloroquine (HCQ), which is hallmarked with a safe and effective profile, but induces a slow and sometimes clinically insufficient therapeutic response. Currently, no biomarkers predictive of response are validated or even proposed in the scientific lit

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Choi, Jong Yun, Young Jae Choi, Sung-No Jung, and Bommie Florence Seo. "Rapidly growing juvenile xanthogranuloma in an adult: a case report." Archives of Aesthetic Plastic Surgery 29, no. 1 (2023): 46–49. http://dx.doi.org/10.14730/aaps.2022.00549.

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Juvenile xanthogranuloma is a benign tumor made up of non-Langerhans histiocytes that predominantly occurs in infancy and early childhood. Juvenile xanthogranuloma can be differentiated from xanthoma by the distribution of the lesions and the absence of lipid abnormalities. It usually develops on the trunk and upper and lower extremities. Histologically, xanthogranulomas show a mixed cellular dermal infiltration with histiocytes, lymphocytes, eosinophils and Touton-type multinucleated giant cells. Classically, juvenile xanthogranuloma is a disease that largely affects infants and children. We

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Sharquie, Khalifa E., and Ammar Faisal Hameed. "Panniculitis Is an Important Feature of Cutaneous Leishmaniasis Pathology." Case Reports in Dermatological Medicine 2012 (2012): 1–4. http://dx.doi.org/10.1155/2012/612434.

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Background. Cutaneous leishmaniasis is an inflammatory parasitic infection characterized by superficial and deep perivascular infiltration with or without granuloma formation. Clinical diagnosis usually requires seeingLeishmaniabodies.Methods. We report two cases of cutaneous leishmaniasis with unusual histological finding of panniculitis. Case 1: a 36-year-old male presented with multiple ulcerative nodules involving the left leg for two months duration which was greatly responsive to antimony intralesional therapy. Case 2: A 45-year-old woman presented with painless nodules on her upper ches

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Hongzhi, Gu, Zhang Lian, and Xiao Yan. "A Case of Amyloidosis Cutis Dyschromica." E3S Web of Conferences 271 (2021): 03002. http://dx.doi.org/10.1051/e3sconf/202127103002.

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The patient was a 56-year-old female. The whole body has brown patches for 16 years. Dermatological examination: brown patches were observed on the trunk and lower limbs, with scattered hypomigmentation patches and symmetrical distribution of skin lesions. Histopathology of the skin showed mild hyperkeratosis in the epidermis, focal liquefaction degeneration in the basal layer, masses of light red stained material in the dermal papilla, scattered or small patches of lymphocytes and tissue cell infiltration around capillaries in the superficial dermis, more pigmentophagocytes and positive methy

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Gimotty, Phyllis A., Patricia Van Belle, David E. Elder, et al. "Biologic and Prognostic Significance of Dermal Ki67 Expression, Mitoses, and Tumorigenicity in Thin Invasive Cutaneous Melanoma." Journal of Clinical Oncology 23, no. 31 (2005): 8048–56. http://dx.doi.org/10.1200/jco.2005.02.0735.

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Purpose Tumor cell proliferation is a central feature of melanoma progression. In this study, we characterized three biomarkers of proliferation (Ki67 expression, dermal mitotic rate [MR], and tumorigenicity) in thin (≤ 1.00 mm) primary cutaneous melanomas and examined their association with prognosis. Patients and Methods We used immunohistochemistry to determine Ki67 expression using the monoclonal antibody MIB-1 in lesions from a prospective cohort that included 396 patients with thin invasive primary melanomas seen between 1972 and 1991. A multivariate Cox proportional hazards model was us

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Li, Claire Y., Hyeung Ju Park, Jinyeon Shin, Jung Eun Baik, Babak J. Mehrara, and Raghu P. Kataru. "Tumor-Associated Lymphatics Upregulate MHC-II to Suppress Tumor-Infiltrating Lymphocytes." International Journal of Molecular Sciences 23, no. 21 (2022): 13470. http://dx.doi.org/10.3390/ijms232113470.

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Steady-state lymphatic endothelial cells (LECs) can induce peripheral tolerance by presenting endogenous antigens on MHC class I (MHC-I) molecules. Recent evidence suggests that lymph node LECs can cross-present tumor antigens on MHC-I to suppress tumor-specific CD8+ T cells. Whether LECs can act as immunosuppressive cells in an MHC-II dependent manner in the local tumor microenvironment (TME) is not well characterized. Using murine heterotopic and spontaneous tumor models, we show that LECs in the TME increase MHC-II expression in the context of increased co-inhibitory signals. We provide evi

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