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Dissertations / Theses on the topic 'Lymphoid progenitors'

Author: Grafiati

Published: 4 June 2021

Last updated: 7 February 2022

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1

Zandi, Sasan. "What’s in a name? : Sub-fractionation of common lymphoid progenitors." Doctoral thesis, Linköpings universitet, Experimentell hematologi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-61590.

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The hematopoietic system is a highly dynamic organ developed in many multi-cellular organisms to provide oxygen, prevent bleeding and to protect against microorganisms. The blood consist of many different specialized cells that all derive from rare hematopoietic stem cells (HSCs) located in the bone marrow in mice and humans. Blood cell production from HSCs occurs in a stepwise manner through development of intermediate progenitors that gradually loose lineage potentials. This is a tightly regulated process with complex regulatory mechanisms and many checkpoints that ensure a high and balanced

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2

Lemoine, François Michel. "Studies of the interactions between stromal cells and B lymphoid progenitors." Thesis, University of British Columbia, 1988. http://hdl.handle.net/2429/28856.

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The overall goal of the work, described in this thesis was to investigate the molecular mechanisms that regulate normal pre-B cell proliferation and how these may be altered in transformed pre-B cells. Monoclonal antibodies and molecular biological techniques have allowed a number of stages of pre-B cell differentiation to be defined but little is known about mechanisms controlling their proliferation. Studies of pre-B cell production in animal models and in long-term cultures that support pre-B cell proliferation have suggested that stromal cells play a key role in this regard. As a first st

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3

Rondeau, Vincent. "Rôle de la désensibilisation de CXCR4 dans la spécification lympho-myéloïde des progéniteurs hématopoïétiques multipotents. Lymphoid differentiation of hematopoietic stem cells requires efficient Cxcr4 desensitization New method to obtain lymphoid progenitors CXCR4-driven mitochondrial metabolic pathways shape the lympho-myeloid fate of hematopoietic multipotent progenitors." Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASQ022.

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Les cellules souches et progéniteurs hématopoïétiques (CSPHs), incluant les progéniteurs multipotents (MPPs), sont responsables de la production des cellules immunes circulantes. Ils résident dans la moelle osseuse (MO) au sein de structures spécialisées, les niches endostéale et (péri)-vasculaire, qui régulent la spécification et l'engagement lymphoïde versus myéloïde des CSPHs. Dans la MO, le couple formé par la chimiokine CXCL12 et l’un de ses récepteurs, CXCR4, exerce un rôle clé dans la régulation de la rétention et la quiescence des CSPHs. Ces processus sont dérégulés dans le Syndrome WH

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4

Reimann, Christian. "In-vitro Generation of potent T-lymphoid Progenitors in a feeder-cell-free DL-4 system." Phd thesis, Université René Descartes - Paris V, 2012. http://tel.archives-ouvertes.fr/tel-00771452.

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Human leukocyte antigen (HLA)-mismatched haematopoietic stem cell transplantation (HSCT) represents an important therapeutic option for patients lacking suitable donors. Delayed posttransplant immune recovery constitutes one of its major complications and is most pronounced in the T cellular compartment. A novel strategy to promote de novo thymopoiesis from donor derived HSCs and to accelerate T cellular reconstitution in patients after HSCT consists in the adoptive transfer of in vitro generated T cell progenitor cells. Identification of Notch1 as the key regulator of early T-lineage developm

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5

Moreira, Pedro Miguel Lopes. "Role of Notch signaling on the differentiation of early lymphoid progenitors cells: a view throughout the development of the embryonic chicken thymus and spleen." Master's thesis, Faculdade de Ciências e Tecnologia, 2014. http://hdl.handle.net/10362/13012.

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Dissertação para a obtenção do grau de Mestre em Genética Molecular e Biomedicina<br>The lymphoid organs, thymus and spleen, are essential for the differentiation of T and B cells, respectively. One of the signaling pathways involved in processes of cell differentiation is the Notch signaling pathway. Work conducted by our group demonstrated that Notch ligands, receptors and target genes are expressed in the thymic epithelium. In this work, we aimed: 1) to study the organogenesis of the thymus and spleen in chicken embryos; 2) phenotypically characterize the cells present in both organs; 3) t

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6

Michaels, Lopez Victoria. "Étude de la migration thymique : vers une reconstitution optimale du compartiment T." Thesis, Sorbonne Paris Cité, 2017. http://www.theses.fr/2017USPCB097/document.

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Notre équipe s’intéresse à la différenciation des cellules souches hématopoïétiques (CSH) vers la lignée des lymphocytes T. Contrairement aux autres lignées sanguines, qui se développent dans la MO, les progéniteurs des lymphocytes T doivent terminer leur différenciation dans le thymus. Ma thèse a un double objectif: 1) caractériser les progéniteurs candidats à la reconstitution T pour établir leur contribution à celle-ci et 2) identifier les stades initiaux de la reconstitution T. Nous avons mis en évidence que seul le progéniteur multipotent au stade 3 (MPP3 : Lin- Sca1+ c-Kit+ VCAM1- Flt3+)

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7

Chabaane, Amna. "Étapes précoces de la lymphopoïèse humaine." Thesis, Université Paris sciences et lettres, 2020. http://www.theses.fr/2020UPSLP027.

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La lymphopoïèse humaine reste mal caractérisée comparativement à son homologue murin. Ceci est dû à l’absence de modèles expérimentaux adéquats et aux difficultés d’accès aux prélèvements primaires de moelle osseuse humaine. Grâce à la caractérisation fine des populations de progéniteurs et précurseurs lymphoïdes présentes dans la moelle osseuse d’animaux greffés, nous avons récemment démontré que la lymphopoïèse humaine suit des voies CD127- ou CD127+ indépendantes qui génèrent une descendance lymphoïde commune et spécifique. Dans cette étude, nous avons mis au point un nouveau test de divers

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8

Larbi, Aniya. "Les cellules souches embryonnaires humaines, un modèle d’étude des étapes précoces de la lymphopoïèse." Thesis, Paris 11, 2013. http://www.theses.fr/2013PA114808.

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Les cellules souches embryonnaires humaines (CSEh) sont des outils puissants pour explorer la genèse des différents tissus de l’organisme, notamment le tissu hématopoïétique. Dans le but d’obtenir des types cellulaires cliniquement utiles, la majorité des travaux se sont concentrés sur l’obtention des cellules hématopoïétiques terminales, notamment des cellules lymphoïdes (lymphocytes B, lymphocyte T et cellules NK), à partir des cellules souches pluripotentes humaines. En revanche, le rendement des cellules hématopoïétiques obtenues dans ce modèle reste faible. D’autre part, les étapes précoc

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9

Ghaedi, Maryam. "Common lymphoid progenitor-independent pathways of innate and T lymphocyte development." Thesis, University of British Columbia, 2015. http://hdl.handle.net/2429/52878.

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All lymphocytes are thought to develop from a single population of committed lymphoid progenitors termed common lymphoid progenitors (CLPs). However, upstream progenitors termed lymphoid-primed multi-potent progenitors (LMPPs) are known to be more efficient than CLPs in differentiating into T cells and group 2 innate lymphoid cells (ILC2s), suggesting alternative pathways of their development. Here, we have divided LMPPs into CD127- (LMPP-s) and CD127+ (LMPP+s) subsets and compared them with CLPs. Adult LMPP+s are the most efficient progenitors for T cells and ILCs in transplantation assays, a

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10

Leyland, R. J. "Lineage relationship analysis of lymphoid progenitor subsets in the bone marrow of naïve mice and during inflammation." Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1322960/.

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During haematopoiesis multipotent stem cells generate all cellular components of the blood including lymphocytes. Despite great progress in the isolation of lineage restricted progenitors, the exact precursor-product relationship of these subsets remains poorly understood. In particular the exact branch point of T- and B-cell development in the bone marrow has not been unequivocally mapped. The aim of my project was to investigate the developmental relationship of various progenitor subsets in normal mice and during an acute inflammation. In order to permanently identify all cells which emanat

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11

Lemoine, François. "Etudes des interactions entre les cellules stromales et les progeniteurs lymphoides b." Paris 7, 1989. http://www.theses.fr/1989PA077206.

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Le but de cette these est d'etudier les mecanismes regulant la proliferation des cellules pre-b normales et de determiner leur alteration au cours de la transformation maligne des cellules pre-b. Differentes etudes realisees a partir de modeles animaux ou de cultures a long terme indiquent que les cellules stromales jouent un role cle. Aussi un certain nombre de lignees stromales supportant la croissance des cellules pre-b de meme que des lignees cellulaires pre-b ont ete isolees, clonees et caracterisees. Certaines de ces lignees pre-b ont ete transformees soit spontanement soit par le virus

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12

Fanning, Niamh Catherine. "Novel ES cell differentiation system enables the generation of low-level repopulating haematopoietic stem cells with lymphoid and myeloid potential." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/17940.

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The potential of embryonic stem (ES) cells to generate any developmental or adult cell type holds much promise for regenerative medicine and in vitro modelling of development and disease. Haematopoietic stem cells (HSCs) regenerate all lineages of the blood throughout adult life and are essential for the treatment of a vast number of haematalogic disorders. Current sources of HSCs for clinical use and research, including adult bone marrow, peripheral blood stem cells and umbilical cord blood, are limited by the number of HSCs they contain and by the availability of a suitable donor. A system t

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13

Beltrame, Luiz Paulo. "Indução de quimerismo hematopoetico misto com fludarabina e irradiação corporal total pre transplante de celulas progenitoras perifericas, em pacientes com neoplasias hematologicas." [s.n.], 2006. http://repositorio.unicamp.br/jspui/handle/REPOSIP/308642.

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Orientador: Carmino Antonio de Souza<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas<br>Made available in DSpace on 2018-08-07T12:06:26Z (GMT). No. of bitstreams: 1 Beltrame_LuizPaulo_D.pdf: 1273755 bytes, checksum: a809e73238738768c971673f3daef900 (MD5) Previous issue date: 2006<br>Resumo: As elevadas taxas de mortalidade após transplante alogênico de medula óssea (TMO) com regime de condicionamento pré-transplante mieloablativo, levou-nos a iniciar a realização destes procedimentos utilizando-se regime de condicionamento pré-transplante não-mieloablat

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14

Ceizar, Maheen. "B-cell Lymphoma-2 (Bcl-2) Is an Essential Regulator of Adult Hippocampal Neurogenesis." Thèse, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/23287.

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Of the thousands of dividing progenitor cells (PCs) generated daily in the adult brain only a very small proportion survive to become mature neurons through the process of neurogenesis. Identification of the mechanisms that regulate cell death associated with neurogenesis would aid in harnessing the potential therapeutic value of PCs. Apoptosis, or programmed cell death, is suggested to regulate death of PCs in the adult brain as overexpression of B-cell lymphoma 2 (Bcl-2), an anti-apoptotic protein, enhances the survival of new neurons. To directly assess if Bcl-2 is a regulator of apoptosis

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15

Moti, Naushad. "ALK-positive anaplastic large cell lymphoma is propagated by cancer stem cells that potentially originate from an early haematopoietic progenitor." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610843.

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16

PONTVERT-DELUCQ, SABINE. "Caracterisation phenotypique et fonctionnelle des cellules souches et des progeniteurs engages myeloides et lymphoides b de la moelle osseuse normale et leucemique." Paris 7, 1995. http://www.theses.fr/1995PA077249.

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Afin d'ameliorer nos connaissances des etapes precoces de l'hematopoiese humaine, nous avons caracterise les cellules cd34++ hla-dr+/- enrichies en progeniteurs tres immatures (ci-clt et hpp-cfc) et les cellules cd34+ hla-dr++ et cd34+ c-kit+ enrichies en progeniteurs clonogeniques myeloides (bfu-e, cfu-gm). Sur ces fractions cd34+, nous avons teste les effets stimulants de combinaisons de facteurs de croissance (fc) ainsi que certains inhibiteurs de l'hematopoiese. Dans des conditions optimales de stimulation (il-3, scf, il-1beta, g-csf, gm-csf, il-6, epo), il apparait que le tetrapeptide acs

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17

CHAMPSEIX, CATHERINE. "Transfert de gene dans les cellules hematopoietiques indifferenciees du sang de cordon ombilical humain ; analyse de son expression dans la descendance myeloide et lymphoide de ces progeniteurs, in vitro et dans la souris scid-hu." Paris 11, 1998. http://www.theses.fr/1998PA112050.

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L'introduction d'un gene therapeutique dans les progeniteurs hematopoietiques de sang placentaire peut representer une approche du traitement de maladies genetiques ou acquises du systeme sanguin, diagnostiquees durant la grossesse. Nous avons transfere le gene marqueur mcd2 dans les precurseurs cd34#+ de sang de cordon ombilical, par culture sur la lignee d'encapsidation crip produisant le vecteur retroviral amphotrope recombinant mfg. L'expression du transgene a ete analysee dans les sous-populations cd34#+ et suivie par cytometrie en flux. Apres 4 jours de coculture, environ 40% des cellule

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18

Azenha, Sara Isabel Rodrigues. "In vivo lineage tracing in lymphopoiesis." Master's thesis, 2020. http://hdl.handle.net/10362/112460.

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Lymphocytes are thought to differentiate from a common progenitor, which either remains in the bone marrow to generate B lymphocytes, or emigrates and, via blood, seeds the thymus to generate T lymphocytes. Such progenitors were originally termed common lymphoid progenitors (CLP), and a bone marrow population with both B and T lymphocyte potential was identified. Although CLP are clearly on their way to feed into the B lymphocyte lineage, their link to the T lymphocyte lineage in physiology is less clear. One concern is that CLP were never found in the thymus. Work from different labs h

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19

Zilhão, Rita 1959. "Embryonic thymic epithelium differentiation in chicken: study of molecular signals involved in lymphoid progenitor cells colonization." Master's thesis, 2012. http://hdl.handle.net/10451/8306.

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Tese de mestrado. Biologia (Biologia Molecular e Genética). Universidade de Lisboa, Faculdade de Ciências, 2012<br>O timo é o órgão linfóide primário responsável pela diferenciação de progenitores hematopoiéticos linfóides (PHL) em linfócitos T maduros. Após o nascimento, os PHL entram no timo através dos vasos sanguíneos e iniciam a timopoiese, processo complexo de diferenciação em linfócitos T. Os PHL começam por especificar-se na linhagem T e depois iniciam o seu longo processo de diferenciação adquirindo coreceptores de membrana característicos das células T maduras, como os marcadores CD3

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20

Almeida, Francisca Monjardino Ferreira de 1987. "Identification of a transient lymphoid population in the murine epidermis." Doctoral thesis, 2015. http://hdl.handle.net/10451/22850.

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Tese de doutoramento, Ciências Biomédicas (Imunologia), Universidade de Lisboa, Faculdade de Medicina, 2015<br>T cell progenitors are known to migrate from the fetal liver in embryos and the bone marrow in adults to the thymus where they differentiate into naïve T cells and then egress to peripheral tissues. However, different studies have shown that a pool of T cell progenitors may also exist in the periphery. Here, we identify a lymphoid population resembling these progenitors which transiently seed the epidermis during late embryogenesis in both WT and T cell-deficient mice, which we named

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