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Journal articles on the topic 'Lymphoid progenitors'

Author: Grafiati

Published: 4 June 2021

Last updated: 7 February 2022

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1

Harly, Christelle, Maggie Cam, Jonathan Kaye, and Avinash Bhandoola. "Development and differentiation of early innate lymphoid progenitors." Journal of Experimental Medicine 215, no. 1 (2017): 249–62. http://dx.doi.org/10.1084/jem.20170832.

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Early innate lymphoid progenitors (EILPs) have recently been identified in mouse adult bone marrow as a multipotential progenitor population specified toward innate lymphoid cell (ILC) lineages, but their relationship with other described ILC progenitors is still unclear. In this study, we examine the progenitor–successor relationships between EILPs, all-lymphoid progenitors (ALPs), and ILC precursors (ILCps). Functional, bioinformatic, phenotypical, and genetic approaches collectively establish EILPs as an intermediate progenitor between ALPs and ILCps. Our work additionally provides new cand

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2

Borikar, Sneha, Vivek Philip, Lauren Kuffler, and Jennifer J. Trowbridge. "Lysine Methyltransferase Kmt5a Restricts Myeloid-Biased Output of Lymphoid-Primed Multipotent Progenitors." Blood 128, no. 22 (2016): 1487. http://dx.doi.org/10.1182/blood.v128.22.1487.1487.

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Abstract Distinct, lineage-biased subsets of multipotent progenitor cells (MPP) dynamically respond to the demands of the hematopoietic system to replenish mature hematopoietic cells as needed. It currently remains unclear as to whether distinct epigenetic mechanisms regulate lineage-specific expansion and differentiation from MPPs. Focusing on lymphoid-primed multipotent progenitor cells (LMPP/MPP4), we performed a lentiviral shRNA screen of 15 epigenetic factors, selected based on differential expression between myeloid-restricted and lymphoid-restricted progenitors. Following a 48 hour infe

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3

Becker, Amy M., Drew G. Michael, Ansuman T. Satpathy, Roger Sciammas, Harinder Singh, and Deepta Bhattacharya. "IRF-8 extinguishes neutrophil production and promotes dendritic cell lineage commitment in both myeloid and lymphoid mouse progenitors." Blood 119, no. 9 (2012): 2003–12. http://dx.doi.org/10.1182/blood-2011-06-364976.

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Abstract While most blood lineages are assumed to mature through a single cellular and developmental route downstream of HSCs, dendritic cells (DCs) can be derived from both myeloid and lymphoid progenitors in vivo. To determine how distinct progenitors can generate similar downstream lineages, we examined the transcriptional changes that accompany loss of in vivo myeloid potential as common myeloid progenitors differentiate into common DC progenitors (CDPs), and as lymphoid-primed multipotent progenitors (LMPPs) differentiate into all lymphoid progenitors (ALPs). Microarray studies revealed t

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4

Karsunky, Holger, Miriam Merad, Antonio Cozzio, Irving L. Weissman, and Markus G. Manz. "Flt3 Ligand Regulates Dendritic Cell Development from Flt3+ Lymphoid and Myeloid-committed Progenitors to Flt3+ Dendritic Cells In Vivo." Journal of Experimental Medicine 198, no. 2 (2003): 305–13. http://dx.doi.org/10.1084/jem.20030323.

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Stimulation of Flt3 receptor tyrosine kinase through its cognate ligand expands early hematopoietic progenitor and dendritic cells (DCs) in humans and mice. The exact developmental stages at which hematopoietic progenitors express Flt3, are responsive to its ligand, and subsequently develop to DCs, are not known. Here we show that common lymphoid and common myeloid progenitors, as well as steady state DCs in thymus, spleen, and epidermis, express Flt3. The receptor is down-regulated once definitive B cell, T cell, and megakaryocyte/erythrocyte commitment occurs, and Flt3 is not detectable on o

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5

Buza-Vidas, Natalija, Petter Woll, Anne Hultquist, et al. "FLT3 expression initiates in fully multipotent mouse hematopoietic progenitor cells." Blood 118, no. 6 (2011): 1544–48. http://dx.doi.org/10.1182/blood-2010-10-316232.

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Abstract Lymphoid-primed multipotent progenitors with down-regulated megakaryocyte-erythroid (MkE) potential are restricted to cells with high levels of cell-surface FLT3 expression, whereas HSCs and MkE progenitors lack detectable cell-surface FLT3. These findings are compatible with FLT3 cell-surface expression not being detectable in the fully multipotent stem/progenitor cell compartment in mice. If so, this process could be distinct from human hematopoiesis, in which FLT3 already is expressed in multipotent stem/progenitor cells. The expression pattern of Flt3 (mRNA) and FLT3 (protein) in

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6

Sitnicka, Ewa, Natalija Buza-Vidas, Henrik Ahlenius, et al. "Critical role of FLT3 ligand in IL-7 receptor–independent T lymphopoiesis and regulation of lymphoid-primed multipotent progenitors." Blood 110, no. 8 (2007): 2955–64. http://dx.doi.org/10.1182/blood-2006-10-054726.

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Abstract The molecular pathways regulating lymphoid priming, fate, and development of multipotent bone marrow (BM) stem/progenitor cells that continuously replace thymic progenitors remain largely unknown. Herein, we show that fms-like tyrosine kinase 3 (Flt3) ligand (Fl)–deficient mice have distinct reductions in the earliest thymic progenitors in fetal, postnatal, and adult thymus. A critical role of FL in thymopoiesis was particularly evident in the absence of interleukin-7 receptor α (IL-7Rα) signaling. Fl−/−Il-7r−/− mice have extensive reductions in fetal and postnatal thymic progenitors

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7

Ryan, Daniel H., Bonnie L. Nuccie, Ion Ritterman, Jane L. Liesveld, Camille N. Abboud, and Richard A. Insel. "Expression of Interleukin-7 Receptor by Lineage-Negative Human Bone Marrow Progenitors With Enhanced Lymphoid Proliferative Potential and B-Lineage Differentiation Capacity." Blood 89, no. 3 (1997): 929–40. http://dx.doi.org/10.1182/blood.v89.3.929.

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Abstract Relatively little is known about the relationship of lymphoid-associated gene expression to the proliferation and differentiation potential of early human bone marrow lymphoid progenitors. Surface expression of interleukin-7 (IL-7) receptor-α (IL-7Rα), a component of the high-affinity receptor for the lymphoid precursor growth factor IL-7, defined a CD34+ progenitor subset lacking the CD19+ pro-B phenotype but demonstrating markedly enhanced lymphoid clonogenic capacity and the ability to differentiate into pro-B cells in short-term culture. These progenitors expressed mRNA for the ly

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8

Arinobu, Yojiro, Shin-ichi Mizuno, Hirokazu Shigematsu, et al. "Delineation of the Common Developmental Pathway for Granulocyte/Monocyte and Lymphoid Lineages by Using an Expression Reporter for PU.1." Blood 108, no. 11 (2006): 1656. http://dx.doi.org/10.1182/blood.v108.11.1656.1656.

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Abstract Understanding how multipotent cells commit to each of their terminal fate potentials is an important aspect of stem cell biology. Hematopoietic stem cells (HSCs) of Lin −Sca-1+c-Kit+ (LSK) phenotype have been purified, which were further divided into CD34-long-term and CD34+ short-term (ST)-HSCs. The existence of phenotypically isolatable common lymphoid progenitors (CLPs) and common myeloid progenitors (CMPs) downstream of ST-HSCs suggests that the first commitment step after the HSC stage is the bifurcation of lymphoid vs. myeloid pathway. Recent studies, however, suggest that the l

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9

Katsura, Yoshimoto. "Redefinition of lymphoid progenitors." Nature Reviews Immunology 2, no. 2 (2002): 127–32. http://dx.doi.org/10.1038/nri721.

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10

Loughran, Stephen J., Federico Comoglio, Fiona K. Hamey, et al. "Mbd3/NuRD controls lymphoid cell fate and inhibits tumorigenesis by repressing a B cell transcriptional program." Journal of Experimental Medicine 214, no. 10 (2017): 3085–104. http://dx.doi.org/10.1084/jem.20161827.

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Differentiation of lineage-committed cells from multipotent progenitors requires the establishment of accessible chromatin at lineage-specific transcriptional enhancers and promoters, which is mediated by pioneer transcription factors that recruit activating chromatin remodeling complexes. Here we show that the Mbd3/nucleosome remodeling and deacetylation (NuRD) chromatin remodeling complex opposes this transcriptional pioneering during B cell programming of multipotent lymphoid progenitors by restricting chromatin accessibility at B cell enhancers and promoters. Mbd3/NuRD-deficient lymphoid p

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11

Hanecak, R., D. C. Zovich, P. K. Pattengale, and H. Fan. "Differentiation in vitro of a leukemia virus-induced B-cell lymphoma into macrophages." Molecular and Cellular Biology 9, no. 5 (1989): 2264–68. http://dx.doi.org/10.1128/mcb.9.5.2264.

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Cells of the hemopoietic system arise by proliferation and differentiation of progenitor cells. This process begins with multipotential stem cells which can self-renew and also undergo progressive differentiation to progenitor cells committed to particular lineages, ultimately yielding mature blood cells (D. Metcalf and M. A. S. Moore, Haematopoietic Cells, 1971). Early commitment of lymphoid progenitors is generally believed to separate the lymphoid lineage from the myeloid and erythroid lineages, whose progenitors are separated late in differentiation (Metcalf and Moore, 1971). We recently d

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12

Hanecak, R., D. C. Zovich, P. K. Pattengale, and H. Fan. "Differentiation in vitro of a leukemia virus-induced B-cell lymphoma into macrophages." Molecular and Cellular Biology 9, no. 5 (1989): 2264–68. http://dx.doi.org/10.1128/mcb.9.5.2264-2268.1989.

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Cells of the hemopoietic system arise by proliferation and differentiation of progenitor cells. This process begins with multipotential stem cells which can self-renew and also undergo progressive differentiation to progenitor cells committed to particular lineages, ultimately yielding mature blood cells (D. Metcalf and M. A. S. Moore, Haematopoietic Cells, 1971). Early commitment of lymphoid progenitors is generally believed to separate the lymphoid lineage from the myeloid and erythroid lineages, whose progenitors are separated late in differentiation (Metcalf and Moore, 1971). We recently d

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13

Saxena, Nivedita Shankar, Jing Huang, Yujun Yang, et al. "Dissection of Complementary Vs Unique Cntributions of Kit, Flt3 and IL-7R Signaling to Lymphohematopoietic Development in Vivo." Blood 124, no. 21 (2014): 1572. http://dx.doi.org/10.1182/blood.v124.21.1572.1572.

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Abstract Lymphohematopoietic development requires partially complementary cytokine signals mediated by the receptor tyrosine kinases Kit and Flt3, while lymphoid development also depends on the Type I cytokine receptor IL-7R. Common lymphoid progenitors (CLP) and the earliest thymic progenitors (ETP) uniquely express all three receptors. Complicating our understanding of the roles of these three cytokine pathways are synergistic cross-receptor interactions by which the RTK can activate non-cognate Type I cytokine receptors, e.g., IL-7R. To unravel the complex interplay between these three path

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14

Purizaca, Jessica, Adriana Contreras-Quiroz, Elisa Dorantes-Acosta, et al. "Lymphoid Progenitor Cells from Childhood Acute Lymphoblastic Leukemia Are Functionally Deficient and Express High Levels of the Transcriptional Repressor Gfi-1." Clinical and Developmental Immunology 2013 (2013): 1–12. http://dx.doi.org/10.1155/2013/349067.

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Acute lymphoblastic leukemia (ALL) is the most frequent malignancy of childhood. Substantial progress on understanding the cell hierarchy within ALL bone marrow (BM) has been recorded in the last few years, suggesting that both primitive cell fractions and committed lymphoid blasts with immature stem cell-like properties contain leukemia-initiating cells. Nevertheless, the biology of the early progenitors that initiate the lymphoid program remains elusive. The aim of the present study was to investigate the ability of lymphoid progenitors from B-cell precursor ALL BM to proliferate and undergo

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15

Reimann, Christian, Liliane Liliane Dal-Cortivo, Emmanuelle M. Six, Andrea Schiavo, Marina Cavazzana-Calvo, and Isabelle Andre-Schmutz. "In Vitro Exposure to DL-4 Increases the in Vitro and In Vivo T-Lymphopoietic Potential of CB Derived CD34+ Progenitor Cells." Blood 118, no. 21 (2011): 2980. http://dx.doi.org/10.1182/blood.v118.21.2980.2980.

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Abstract Abstract 2980 Notchligand-based culture systems such as OP9-DL1 cells induce HSC to engage towards the T-cell developmental program and allow generation of T-lymphoid progenitors in vitro. In vitro generated murine T-lymphoid progenitors accelerated T-cell reconstitution in vivo. In consistency, human T-lymphoid progenitors generated in co-culture with OP9-DL1 cells enhanced thymic repopulation when injected into NOD/SCID/gc−/− mice (NSG). However, positive effects of human T-lymphoid progenitors on peripheral T-cell reconstitution have not been reported yet. Besides, Notchligand-base

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16

Liu, Qingyang, Myung H. Kim, Leon Friesen, and Chang H. Kim. "BATF regulates innate lymphoid cell hematopoiesis and homeostasis." Science Immunology 5, no. 54 (2020): eaaz8154. http://dx.doi.org/10.1126/sciimmunol.aaz8154.

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Early hematopoietic progenitors undergo sophisticated developmental processes to become committed innate lymphoid cell (ILC) progenitors and ultimately mature ILC subsets in the periphery. Basic leucine zipper ATF-like transcription factor (Batf) plays important roles in lymphocyte biology. We report here that Batf regulates the production of bone marrow ILC progenitors and maintenance of peripheral ILCs. The expression of Batf is induced during ILC development at the α-lymphoid progenitor stage in response to the cytokine IL-7. As a potential mechanism, up-regulated Batf binds and activates t

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17

Kohno, Kentaro, Hiromi Iwasaki, Tadafumi Iino, Shin-ichi Mizuno, Peter Sicinski, and Koichi Akashi. "Cyclin A2 Plays a Critical Role in Proliferation of Lymphoid Progenitors." Blood 118, no. 21 (2011): 914. http://dx.doi.org/10.1182/blood.v118.21.914.914.

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Abstract Abstract 914 Cell cycle regulators could be differentially used among self–renewing stem cells, rapidly expanding progenitor cells, and terminally differentiated cells those clonally replicate. Cyclin A is a regulatory subunit for cyclin dependent kinase (Cdk) 1 and Cdk2, and it drives S phase progression as well as transition to G2/M phase in cell cycle. We have previously reported that cyclin A2 is not required for fibroblast replication but it is indispensable in maintenance of self-renewing stem cells, including embryonic stem cells and hematopoietic stem cells (HSCs) (Cell 138 20

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18

Welner, Robert S., Rosana Pelayo, Yoshinori Nagai, et al. "Lymphoid precursors are directed to produce dendritic cells as a result of TLR9 ligation during herpes infection." Blood 112, no. 9 (2008): 3753–61. http://dx.doi.org/10.1182/blood-2008-04-151506.

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Abstract Hematopoietic stem and progenitor cells were previously found to express Toll-like receptors (TLRs), suggesting that bacterial/viral products may influence blood cell formation. We now show that common lymphoid progenitors (CLPs) from mice with active HSV-1 infection are biased to dendritic cell (DC) differentiation, and the phenomenon is largely TLR9 dependent. Similarly, CLPs from mice treated with the TLR9 ligand CpG ODN had little ability to generate CD19+ B lineage cells and had augmented competence to generate DCs. TNFα mediates the depletion of late-stage lymphoid progenitors f

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Chicha, Laurie, David Jarrossay, and Markus G. Manz. "Clonal Type I Interferon–producing and Dendritic Cell Precursors Are Contained in Both Human Lymphoid and Myeloid Progenitor Populations." Journal of Experimental Medicine 200, no. 11 (2004): 1519–24. http://dx.doi.org/10.1084/jem.20040809.

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Because of different cytokine responsiveness, surface receptor, and transcription factor expression, human CD11c− natural type I interferon–producing cells (IPCs) and CD11c+ dendritic cells were thought to derive through lymphoid and myeloid hematopoietic developmental pathways, respectively. To directly test this hypothesis, we used an in vitro assay allowing simultaneous IPC, dendritic cell, and B cell development and we tested lymphoid and myeloid committed hematopoietic progenitor cells for their developmental capacity. Lymphoid and common myeloid and granulocyte/macrophage progenitors wer

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20

Greig, Kylie T., Carolyn A. de Graaf, James M. Murphy, et al. "Critical roles for c-Myb in lymphoid priming and early B-cell development." Blood 115, no. 14 (2010): 2796–805. http://dx.doi.org/10.1182/blood-2009-08-239210.

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Abstract c-Myb is a transcription factor with functions in many hematopoietic lineages. c-Myb–deficient mice display reduced numbers of B cells; however, it is unknown what role c-Myb plays in B lymphopoiesis because no critical target genes have been identified in the B-cell lineage. We demonstrate that conditional deletion of c-Myb in B-cell progenitors completely abolishes B-cell development. c-Myb is required for lymphoid progenitors to respond to the cytokines interleukin-7 and thymic stromal lymphopoietin; in the absence of sufficient c-Myb activity, mice display a B lymphopenia that clo

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Ooehara, Jun, Hina Takano, Shin-ichiro Takayanagi, Hiromitsu Nakauchi, and Hideo Ema. "In Vitro Myelo-Lymphoid Colony Formation by Mouse Hematopoietic Stem Cells." Blood 112, no. 11 (2008): 3861. http://dx.doi.org/10.1182/blood.v112.11.3861.3861.

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Abstract Hematopoietic stem cells (HSCs) clonally differentiate into all myeloid, B-lymphoid, and T-lymphoid lineages. Mouse HSCs are known to form in vitro colonies comprised of morphologically identifiable myeloid cells such as neutrophils, macrophages, erythroblasts, and megakaryocytes. Whether HSCs are able to differentiate along B-and T-lymphoid lineages in such colonies remains obscure. The co-culture systems with stromal cells such as S17, OP9, OP9/Delta cells have been shown to support B- and T-cell development. These systems have been used to identify subclasses of progenitors with ly

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22

Hao, Qian-Lin, Aswathi A. George, Judy Zhu, et al. "Human intrathymic lineage commitment is marked by differential CD7 expression: identification of CD7− lympho-myeloid thymic progenitors." Blood 111, no. 3 (2008): 1318–26. http://dx.doi.org/10.1182/blood-2007-08-106294.

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Abstract The identity and lineage potential of the cells that initiate thymopoiesis remain controversial. The goal of these studies was to determine, at a clonal level, the immunophenotype and differentiation pathways of the earliest progenitors in human thymus. Although the majority of human CD34+lin− thymocytes express high levels of CD7, closer analysis reveals that a continuum of CD7 expression exists, and 1% to 2% of progenitors are CD7−. CD34+lin− thymocytes were fractionated by CD7 expression and tested for lineage potential in B-lymphoid, T-lymphoid, and myeloid-erythroid conditions. P

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Amrani, Yacine M., Jonathan Gill, Armine Matevossian, et al. "The Paf oncogene is essential for hematopoietic stem cell function and development." Journal of Experimental Medicine 208, no. 9 (2011): 1757–65. http://dx.doi.org/10.1084/jem.20102170.

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Hematopoietic stem cells (HSCs) self-renew to maintain the lifelong production of all blood populations. Here, we show that the proliferating cell nuclear antigen–associated factor (Paf) is highly expressed in cycling bone marrow HSCs and plays a critical role in hematopoiesis. Mice lacking Paf exhibited reduced bone marrow cellularity; reduced numbers of HSCs and committed progenitors; and leukopenia. These phenotypes are caused by a cell-intrinsic blockage in the development of long-term (LT)-HSCs into multipotent progenitors and preferential loss of lymphoid progenitors caused by markedly i

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Richie Ehrlich, Lauren I., Thomas Serwold, and Irving L. Weissman. "In vitro assays misrepresent in vivo lineage potentials of murine lymphoid progenitors." Blood 117, no. 9 (2011): 2618–24. http://dx.doi.org/10.1182/blood-2010-05-287102.

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Abstract The identity of T-cell progenitors that seed the thymus has remained controversial, largely because many studies differ over whether these progenitors retain myeloid potential. Contradictory reports diverge in their use of various in vitro and in vivo assays. To consolidate these discordant findings, we compared the myeloid potential of 2 putative thymus seeding populations, common lymphoid progenitors (CLPs) and multipotent progenitors (MPPs), and the earliest intrathymic progenitor (DN1), using 2 in vitro assays and in vivo readouts. These assays gave contradictory results: CLP and

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Serwold, Thomas, Lauren I. Richie Ehrlich, and Irving L. Weissman. "Reductive isolation from bone marrow and blood implicates common lymphoid progenitors as the major source of thymopoiesis." Blood 113, no. 4 (2009): 807–15. http://dx.doi.org/10.1182/blood-2008-08-173682.

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Abstract Ongoing thymopoiesis requires continual seeding from progenitors that reside within the bone marrow (BM), but the identity of the most proximate prethymocytes has remained controversial. Here we take a comprehensive approach to prospectively identify the major source of thymocyte progenitors that reside within the BM and blood, and find that all thymocyte progenitor activity resides within a rare Flk2+CD27+ population. The BM Flk2+CD27+ subset is predominantly composed of common lymphoid progenitors (CLPs) and multipotent progenitors. Of these 2 populations, only CLPs reconstitute thy

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Simmons, Szandor, Marko Knoll, Christopher Drewell, et al. "Biphenotypic B-lymphoid/myeloid cells expressing low levels of Pax5: potential targets of BAL development." Blood 120, no. 18 (2012): 3688–98. http://dx.doi.org/10.1182/blood-2012-03-414821.

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Abstract The expression of Pax5 commits common lymphoid progenitor cells to B-lymphoid lineage differentiation. Little is known of possible variations in the levels of Pax5 expression and their influences on hematopoietic development. We have developed a retroviral transduction system that allows for the study of possible intermediate stages of this commitment by controlling the levels of Pax5 expressed in Pax5-deficient progenitors in vitro and in vivo. Retroviral transduction of Pax5-deficient pro-/pre-B cell lines with a doxycycline-inducible (TetON) form of the human Pax5 (huPax5) gene yie

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Abdel-Azim, Hisham, Yuhua Zhu, Roger Hollis, et al. "Expansion of multipotent and lymphoid-committed human progenitors through intracellular dimerization of Mpl." Blood 111, no. 8 (2008): 4064–74. http://dx.doi.org/10.1182/blood-2007-08-107466.

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AbstractSelf-renewal capacity is rapidly lost during differentiation of hematopoietic stem cells to lineage-committed progenitors. We demonstrate here that regulated intracellular signaling through the cytokine receptor Mpl induces profound expansion of not only multipotent (ie, lymphomyeloid) but also lymphoid-committed human hematopoietic progenitors. A fusion protein containing the intracellular signaling domain of Mpl and a dimerization domain was constitutively expressed in populations enriched in human lymphomyeloid progenitor/stem cells (CD34+CD38−Lin−CD7−) and multilymphoid progenitors

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28

So, Chi Wai, Holger Karsunky, Piu Wong, Irving L. Weissman, and Michael L. Cleary. "Leukemic transformation of hematopoietic progenitors by MLL-GAS7 in the absence of Hoxa7 or Hoxa9." Blood 103, no. 8 (2004): 3192–99. http://dx.doi.org/10.1182/blood-2003-10-3722.

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Abstract Differential expression of Hox genes is associated with normal hematopoiesis, whereas inappropriate maintenance of Hox gene expression, particularly Hoxa7 and Hoxa9, is a feature of leukemias harboring mixed-lineage leukemia (MLL) mutations. To understand the pathogenic roles of Hox genes in MLL leukemias, we assessed the impact of Hoxa7 or Hoxa9 nullizygosity on hematopoietic progenitor compartments and their susceptibility to MLL-induced leukemias. Selective reductions in the absolute numbers of committed progenitors, but not of hematopoietic stem cells, distinguished Hoxa7- and Hox

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Prohaska, Susan S., David C. Scherer, Irving L. Weissman, and Motonari Kondo. "Developmental plasticity of lymphoid progenitors." Seminars in Immunology 14, no. 6 (2002): 377–84. http://dx.doi.org/10.1016/s1044532302000726.

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Six, Emmanuelle, Delphine Bonhomme, Kheira Beldjord, et al. "Characterization of Post Natal Human Lymphoid Progenitors." Blood 108, no. 11 (2006): 1659. http://dx.doi.org/10.1182/blood.v108.11.1659.1659.

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Abstract In humans, little is known about post-natal lymphoid progenitors, especially those able to circulate, colonize the thymus and generate T lymphocytes. On the basis of a previous work published by Anne Galy in 1995, we have detected in the human post-natal bone marrow up to 60 yrs of age a population of progenitors characterized by their CD34+Lin-CD10+ phenotype. Their differentiation potential analysed by culture in methylcellulose medium indicated that in contrast with their CD10− counterparts, CD10+ progenitors have lost erythroid and myeloid potential. On the other hand, CD10+ proge

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Cumano, Ana, Claire Berthault, Cyrille Ramond, et al. "New Molecular Insights into Immune Cell Development." Annual Review of Immunology 37, no. 1 (2019): 497–519. http://dx.doi.org/10.1146/annurev-immunol-042718-041319.

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During development innate lymphoid cells and specialized lymphocyte subsets colonize peripheral tissues, where they contribute to organogenesis and later constitute the first line of protection while maintaining tissue homeostasis. A few of these subsets are produced only during embryonic development and remain in the tissues throughout life. They are generated through a unique developmental program initiated in lympho-myeloid-primed progenitors, which lose myeloid and B cell potential. They either differentiate into innate lymphoid cells or migrate to the thymus to give rise to embryonic T ce

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Doulatov, Sergei, Faiyaz Notta, and John E. Dick. "Clonal Analysis of the Human Hematopoietic Hierarchy Reveals An Early Lymphoid Progenitor with Extensive Monocytic Potential." Blood 114, no. 22 (2009): 1503. http://dx.doi.org/10.1182/blood.v114.22.1503.1503.

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Abstract Abstract 1503 Poster Board I-526 The classical model of hematopoiesis posits the segregation of lymphoid and myeloid lineages as the earliest fate decision. Although the validity of this model in the mouse has recently been questioned, its status in human hematopoiesis is unclear, since little is known concerning lineage potential of human progenitors at the clonal level. We isolated and clonally mapped the developmental potential of each major progenitor class from neonatal cord blood and adult bone marrow providing the first comprehensive analysis of the human hematopoietic hierarch

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33

Mende, Ines, Holger Karsunky, Irving L. Weissman, Edgar G. Engleman, and Miriam Merad. "Flk2+ myeloid progenitors are the main source of Langerhans cells." Blood 107, no. 4 (2006): 1383–90. http://dx.doi.org/10.1182/blood-2005-05-1878.

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Langerhans cells (LCs) are antigen-presenting cells (APCs) residing in the epidermis that play a major role in skin immunity. Our earlier studies showed that when skin is inflamed LCs are replaced by bone marrow-derived progenitor cells, while during steady-state conditions LCs are able to self-renew in the skin. Identification of the LC progenitors in bone marrow would represent a critical step toward identifying the factors that regulate LC generation as well as their trafficking to the skin. To determine LC lineage origin, we reconstituted lethally irradiated CD45.2 mice with rigorously pur

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34

Luc, Sidinh, Iain C. Macaulay, Natalija Buza-Vidas, et al. "The Earliest Thymic T Cell Progenitors Sustain B Cell and Myeloid Lineage Potentials." Blood 118, no. 21 (2011): 2335. http://dx.doi.org/10.1182/blood.v118.21.2335.2335.

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Abstract Abstract 2335 The stepwise lineage-commitment from hematopoietic stem cells (HSCs) in the bone marrow (BM) to T-lymphocyte-restricted progenitors in the thymus represents a paradigm for how distinct stages of lineage restriction from a multipotent to a lineage-restricted progenitor require different extrinsic cues. However, the commitment stage at which progenitors migrate from the BM to the thymus remains unclear. Previous studies demonstrated the existence of adult early thymic progenitors (ETPs) restricted to T lymphocyte and granulocyte-monocyte (GM) fates (Bell and Bhandoola, Nat

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35

Canque, Bruno, Sandrine Camus, Ali Dalloul, et al. "Characterization of dendritic cell differentiation pathways from cord blood CD34+CD7+CD45RA+hematopoietic progenitor cells." Blood 96, no. 12 (2000): 3748–56. http://dx.doi.org/10.1182/blood.v96.12.3748.

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Abstract To better characterize human dendritic cells (DCs) that originate from lymphoid progenitors, the authors examined the DC differentiation pathways from a novel CD7+CD45RA+ progenitor population found among cord blood CD34+ cells. Unlike CD7−CD45RA+ and CD7+CD45RA− progenitors, this population displayed high natural killer (NK) cell differentiation capacity when cultured with stem cell factor (SCF), interleukin (IL)-2, IL-7, and IL-15, attesting to its lymphoid potential. In cultures with SCF, Flt3 ligand (FL), granulocyte-macrophage colony-stimulating factor (GM-CSF), and tumor necrosi

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Canque, Bruno, Sandrine Camus, Ali Dalloul, et al. "Characterization of dendritic cell differentiation pathways from cord blood CD34+CD7+CD45RA+hematopoietic progenitor cells." Blood 96, no. 12 (2000): 3748–56. http://dx.doi.org/10.1182/blood.v96.12.3748.h8003748_3748_3756.

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To better characterize human dendritic cells (DCs) that originate from lymphoid progenitors, the authors examined the DC differentiation pathways from a novel CD7+CD45RA+ progenitor population found among cord blood CD34+ cells. Unlike CD7−CD45RA+ and CD7+CD45RA− progenitors, this population displayed high natural killer (NK) cell differentiation capacity when cultured with stem cell factor (SCF), interleukin (IL)-2, IL-7, and IL-15, attesting to its lymphoid potential. In cultures with SCF, Flt3 ligand (FL), granulocyte-macrophage colony-stimulating factor (GM-CSF), and tumor necrosis factor

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Calés, Carmela, Leticia Pavón, Katarzyna Starowicz, et al. "Role of Polycomb RYBP in Maintaining the B-1-to-B-2 B-Cell Lineage Switch in Adult Hematopoiesis." Molecular and Cellular Biology 36, no. 6 (2015): 900–912. http://dx.doi.org/10.1128/mcb.00869-15.

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Polycomb chromatin modifiers regulate hematopoietic pluripotent stem and progenitor cell self-renewal and expansion. Polycomb complex redundancy and biochemical heterogeneity complicate the unraveling of the functional contributions of distinct components. We have studied the hematopoietic activity of RYBP, a direct interactor and proposed modulator of RING1A/RING1B-dependent histone H2A monoubiquitylation (H2AUb). Using a mouse model to conditionally inactivateRybpin adult hematopoiesis, we have found that RYBP deletion results in a reversion of B-1-to-B-2 B-cell progenitor ratios, i.e., of t

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Harman, Benjamin C., Juli P. Miller, Neda Nikbakht, Rachel Gerstein, and David Allman. "Mouse plasmacytoid dendritic cells derive exclusively from estrogen-resistant myeloid progenitors." Blood 108, no. 3 (2006): 878–85. http://dx.doi.org/10.1182/blood-2005-11-4545.

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Abstract Current models predict that mouse plasmacytoid dendritic cells (PDCs) derive from lymphoid progenitors. However, we show PDCs arise exclusively from common myeloid progenitors (CMPs) characterized by low-level expression of several lymphoid-associated genes, including a RAG2/GFP reporter transgene. This conclusion is supported by both adoptive transfer experiments and an estrogen treatment strategy that led to marked depletion of very early lymphoid progenitors without affecting RAG2/GFP+ CMPs or the developmental kinetics, RAG-mediated recombinase activity, and cytokine production of

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Nagaharu, Keiki, Kohshi Ohishi, and Naoyuki Katayama. "Novel Lymphoid Pathway of Human Plasmacytoid and Conventional Dendritic Cells." Blood 134, Supplement_1 (2019): 4998. http://dx.doi.org/10.1182/blood-2019-121448.

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[Introduction] Dendritic cells (DCs) play a central role in initiation and regulation of immune response. Human plasmacytoid DCs (pDCs) as well as conventional DCs (cDCs) were shown to differentiate from multi-lymphoid progenitors (MLPs) as well as myeloid progenitors via common DC progenitors. However, lymphoid pathway of DCs remained clarified. Here we investigated lymphoid origin of DCs, using a novel co-culture system which supports differentiation of various lineages of lymphoid and DCs (Br J Haematol. 157:674, 2012; J Immunol. 199:2343, 2017). [Methods and Results] CD34+CD38-CD45RA-CD10-

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Traver, David, Toshihiro Miyamoto, Julie Christensen, Junko Iwasaki-Arai, Koichi Akashi, and Irving L. Weissman. "Fetal liver myelopoiesis occurs through distinct, prospectively isolatable progenitor subsets." Blood 98, no. 3 (2001): 627–35. http://dx.doi.org/10.1182/blood.v98.3.627.

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Abstract Hematopoietic fate maps in the developing mouse embryo remain imprecise. Definitive, adult-type hematopoiesis first appears in the fetal liver, then progresses to the spleen and bone marrow. Clonogenic common lymphoid progenitors and clonogenic common myeloid progenitors (CMPs) in adult mouse bone marrow that give rise to all lymphoid and myeloid lineages, respectively, have recently been identified. Here it is shown that myelopoiesis in the fetal liver similarly proceeds through a CMP equivalent. Fetal liver CMPs give rise to megakaryocyte–erythrocyte-restricted progenitors (MEPs) an

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Su, Ruijun, Terry-Ann Milford, Ineavely Baez, Abby Jones Weldon, Sinisa Dovat, and Kimberly J. Payne. "Expression of the IL-7R Identifies a Human Common Lymphoid Progenitor (CLP) In Cord Blood Lymphopoiesis." Blood 116, no. 21 (2010): 1603. http://dx.doi.org/10.1182/blood.v116.21.1603.1603.

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Abstract Abstract 1603 Expression of the IL-7 receptor alpha (IL-7R) is a distinguishing feature of common lymphoid progenitors (CLP) in the mouse. Human B cell development has been thought to differ from that in mouse with respect to the requirement for IL-7, and markers other than IL-7R have been used to identify human progenitor populations enriched for CLP activity. Our previous studies show that IL-7 is essential for adult human B lymphopoiesis and critical for B cell production from hematopietic stem cells (HSCs) in umbilical blood (CB) (J Immunol. 2009, 182:4255). Here we use IL-7R expr

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Susini, Sandrine, Séverine Mouraud, Elodie Elkaim, et al. "From the Bone Marrow to the Thymic Niche." Blood 124, no. 21 (2014): 5123. http://dx.doi.org/10.1182/blood.v124.21.5123.5123.

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Abstract To generate T cells throughout adult life, the thymus must import hematopoietic progenitor cells from the bone marrow via the blood. The cellular and molecular mechanisms governing the circulation of thymus-seeding progenitor cells are well characterized in mice but not in humans. The aim of the present study was to characterize the molecular mechanisms and cellular components involved in thymus colonization by lymphoid progenitors (CD34+/CD10+/CD7-/CD24-) and the early steps of thymopoiesis under physiological conditions in humans. Our results demonstrate that circulating lymphoid pr

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Kawano, Yohei, Georg Petkau, Christina Stehle, et al. "Stable lines and clones of long-term proliferating normal, genetically unmodified murine common lymphoid progenitors." Blood 131, no. 18 (2018): 2026–35. http://dx.doi.org/10.1182/blood-2017-09-805259.

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Key Points We have established a novel culture system for long-term proliferating murine lymphoid progenitors without any genetic manipulation. The cultured lymphoid progenitors can differentiate to lymphoid and myeloid lineages in vitro and in vivo.

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Hao, Qian-Lin, Judy Zhu, Mary A. Price, Kimberly J. Payne, Lora W. Barsky, and Gay M. Crooks. "Identification of a novel, human multilymphoid progenitor in cord blood." Blood 97, no. 12 (2001): 3683–90. http://dx.doi.org/10.1182/blood.v97.12.3683.

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The earliest stages of lymphoid commitment from human pluripotent hematopoietic stem cells have not been defined. A clonogenic subpopulation of CD34+CD38− cord blood cells were identified that expressed high levels of the CD7 antigen and possessed only lymphoid potential. CD34+CD38−CD7+ (CD7+) cells uniformly coexpressed CD45RA and HLA-DR;c-kit and Thy-1 expression was absent to low. Clonal analysis demonstrated that single CD7+ cells could generate B cells, natural killer cells, and dendritic cells but were devoid of myeloid or erythroid potential. In contrast, control CD34+CD38−CD7−(CD7−) ce

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Arinobu, Yojiro, Shin-ichi Mizuno, Yong Chong, et al. "Reciprocal Activation of GATA-1 and PU.1 Marks Initial Specification of Hematopoietic Stem Cells into Myelo-Erythroid and Myelo-Lymphoid Lineages." Blood 110, no. 11 (2007): 1228. http://dx.doi.org/10.1182/blood.v110.11.1228.1228.

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Abstract Understanding how multipotent cells commit to each of their terminal fate potentials is an important aspect of stem cell biology. In adult murine hematopoiesis, HSCs with long-term self-renewal potential reside within the Lin −Sca-1+c-Kit+ (LSK) fraction having CD34−, Thy1lo, and Flt3/Flk2−phenotypes. The LSK cells having CD34+, Thy1−, and/or Flt3+ phenotypes are capable of multi-lineage reconstitution only for a short-term, and therefore should contain multipotent progenitors (MPPs). In terms of developmental steps downstream of MPPs, there has been a controversy. The existence of pr

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Dakic, Aleksandar, Donald Metcalf, Ladina Di Rago, Sandra Mifsud, Li Wu, and Stephen L. Nutt. "PU.1 regulates the commitment of adult hematopoietic progenitors and restricts granulopoiesis." Journal of Experimental Medicine 201, no. 9 (2005): 1487–502. http://dx.doi.org/10.1084/jem.20050075.

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Although the transcription factor PU.1 is essential for fetal lymphomyelopoiesis, we unexpectedly found that elimination of the gene in adult mice allowed disturbed hematopoiesis, dominated by granulocyte production. Impaired production of lymphocytes was evident in PU.1-deficient bone marrow (BM), but myelocytes and clonogenic granulocytic progenitors that are responsive to granulocyte colony-stimulating factor or interleukin-3 increased dramatically. No identifiable common lymphoid or myeloid progenitor populations were discernable by flow cytometry; however, clonogenic assays suggested an o

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Punzel, M., S. D. Wissink, J. S. Miller, K. A. Moore, I. R. Lemischka, and C. M. Verfaillie. "The Myeloid-Lymphoid Initiating Cell (ML-IC) Assay Assesses the Fate of Multipotent Human Progenitors In Vitro." Blood 93, no. 11 (1999): 3750–56. http://dx.doi.org/10.1182/blood.v93.11.3750.411a37_3750_3756.

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Hematopoietic stem cells (HSC) are cells with self-renewing multilineage differentiation potential. Although engraftment in xenogeneic recipients can be used to measure human HSC, these assays do not allow assessment of individual progenitors. We developed an in vitro assay that allows the identification of a single human bone marrow progenitor closely related to HSC, which we termed “Myeloid-Lymphoid Initiating Cell,” or ML-IC, because it is capable of generating multiple secondary progenitors that can reinitiate long-term myeloid and lymphoid hematopoiesis in vitro. The assay is done in cont

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Saran, Namita, Marcin Łyszkiewicz, Jens Pommerencke, et al. "Multiple extrathymic precursors contribute to T-cell development with different kinetics." Blood 115, no. 6 (2010): 1137–44. http://dx.doi.org/10.1182/blood-2009-07-230821.

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Abstract T-cell development in the thymus depends on continuous supply of T-cell progenitors from bone marrow (BM). Several extrathymic candidate progenitors have been described that range from multipotent cells to lymphoid cell committed progenitors and even largely T-lineage committed precursors. However, the nature of precursors seeding the thymus under physiologic conditions has remained largely elusive and it is not known whether there is only one physiologic T-cell precursor population or many. Here, we used a competitive in vivo assay based on depletion rather than enrichment of classes

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Huntly, Brian J. P., Sarah Jayne Horton, George Giotopoulos, et al. "Early Loss of CREBBP Confers Malignant Stem Cell Properties on Lymphoid Progenitors." Blood 128, no. 22 (2016): 460. http://dx.doi.org/10.1182/blood.v128.22.460.460.

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Abstract Loss-of-function mutations of the cyclic-AMP response element binding protein, binding protein (CREBBP) gene have recently been described at high frequencies across a spectrum of lymphoid malignancies, particularly follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL). The multiple effects of this epigenetic regulator on developmental and homeostatic processes have been extensively studied, however, exactly how CREBBP functions as a tumor suppressor and the reasons for its particular predilection for suppression of lymphoid tumors remains unclear. In addition, for many ma

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Miller, Jeffrey S., Felipe Prosper, and Valarie McCullar. "Natural Killer (NK) Cells Are Functionally Abnormal and NK Cell Progenitors Are Diminished in Granulocyte Colony-Stimulating Factor–Mobilized Peripheral Blood Progenitor Cell Collections." Blood 90, no. 8 (1997): 3098–105. http://dx.doi.org/10.1182/blood.v90.8.3098.

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Abstract Granulocyte colony-stimulating factor (G-CSF)–mobilized peripheral blood progenitor cell (PBPC) collections are increasingly emerging as the graft of choice in many centers for autologous transplantation, and with increasing frequency for allogeneic transplantation. However, the role of myeloid cytokines in lymphoid function, lymphoid progenitors, and immune-mediated antitumor responses is not known. We studied PBPC collections from normal donors mobilized with G-CSF (10 μg/kg). CD56+/CD3− natural killer (NK) cells sorted from PBPC products exhibited a diminished ability to kill tumor

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