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Journal articles on the topic 'Lympholytes T'

Author: Grafiati

Published: 4 June 2021

Last updated: 8 February 2022

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1

Morris, Emma C., Peppy Rebello, Kirsty J. Thomson, et al. "Pharmacokinetics of alemtuzumab used for in vivo and in vitro T-cell depletion in allogeneic transplantations: relevance for early adoptive immunotherapy and infectious complications." Blood 102, no. 1 (2003): 404–6. http://dx.doi.org/10.1182/blood-2002-09-2687.

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Abstract Persistence of alemtuzumab at lympholytic concentrations after reduced-intensity conditioning allogeneic stem cell transplantations (RITs) could impair immune reconstitution and reduce donor T-cell–mediated graft-versus-leukemia/lymphoma (GVL) effects, derived from the graft or subsequent adoptive immunotherapy. We have studied the pharmacokinetics of alemtuzumab in 2 different groups: RIT (100 mg alemtuzumab in vivo over 5 days) and myeloablative allografts (20 mg alemtuzumab added in vitro to the stem cells prior to return). Alemtuzumab concentrations in RIT patients were in excess

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2

Schirren, CA, H. Volpel, and SC Meuer. "Adhesion molecules on freshly recovered T leukemias promote tumor- directed lympholysis." Blood 79, no. 1 (1992): 138–43. http://dx.doi.org/10.1182/blood.v79.1.138.138.

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Abstract Besides facilitating cell to cell adhesion, the molecular interactions between CD2 and its ligand CD58 (lymphocyte function-associated antigen- 3 [LFA-3]), as well as between CD11a/18 (LFA-1) and CD54 (intercellular adhesion molecule-1) have recently been recognized to participate in lymphocyte activation, recirculation, and effector function, including cytolytic activity towards tumor cells. We have investigated the role of CD2/CD58 and CD11a/18/CD54 interactions in cellular immune responses directed towards freshly recovered human T-cell leukemias. The data support the notion that d

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3

Schirren, CA, H. Volpel, and SC Meuer. "Adhesion molecules on freshly recovered T leukemias promote tumor- directed lympholysis." Blood 79, no. 1 (1992): 138–43. http://dx.doi.org/10.1182/blood.v79.1.138.bloodjournal791138.

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Besides facilitating cell to cell adhesion, the molecular interactions between CD2 and its ligand CD58 (lymphocyte function-associated antigen- 3 [LFA-3]), as well as between CD11a/18 (LFA-1) and CD54 (intercellular adhesion molecule-1) have recently been recognized to participate in lymphocyte activation, recirculation, and effector function, including cytolytic activity towards tumor cells. We have investigated the role of CD2/CD58 and CD11a/18/CD54 interactions in cellular immune responses directed towards freshly recovered human T-cell leukemias. The data support the notion that downregula

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4

Kristensen, Tom. "Human Histocompatibility Testing by T Cell-Mediated Lympholysis: A European Standard CML Technique." Tissue Antigens 16, no. 5 (2008): 335–67. http://dx.doi.org/10.1111/j.1399-0039.1980.tb00316.x.

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5

Owens, William J., Thomas C. Cesario, and Edward Shanbrom. "Selective Lympholysis: A Unique Method Using the Double-Dye Technique." Blood 108, no. 11 (2006): 3884. http://dx.doi.org/10.1182/blood.v108.11.3884.3884.

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Abstract Many methods are utilized to destroy mononuclear cells (primarily lymphocytes) either for neoplasm or immunosuppression. Neither radiation nor chemotherapy are truly selective or completely successful. The concept of “Double-Dye” treatment of blood for transfusion has been developed in order to inactivate parasites, bacteria and viruses (J Thromb Haemost2003; 1 Supplement 1 July: P1114). In recent studies, it has been observed that this same “Double-Dye” concept presents the possibility of very selectively eliminating lymphocytes (mononuclear cells) without affecting neutrophils in wh

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6

and, Adriana Zeevi, and Rene J. Duquesnoy. "SPECIFICITY OF ALLOACTIVATED HUMAN T LYMPHOCYTE CLONES IN SECONDARY PROLIFERATION, CELL-MEDIATED LYMPHOLYSIS AND INTERLEUKIN-2 RELEASE." European Journal of Immunogenetics 12, no. 1 (1985): 17–31. http://dx.doi.org/10.1111/j.1744-313x.1985.tb00826.x.

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7

Vasilyeva, Vera, Elena N. Parovichnikova, Larisa A. Kuzmina, et al. "Reconstitution of Memory T -Cells after Allogeneic Stem Cell Transplantation in Patients with Post-Transplantation Cyclophosphamide As Tolerance Induction." Blood 126, no. 23 (2015): 5475. http://dx.doi.org/10.1182/blood.v126.23.5475.5475.

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Abstract Introduction. Nowadays high-dose post-transplantation cyclophosphamide (CY) replace standard immunosuppression (IST). Thereby, the investigation of T-cells reconstitution after post-transplant-CY doesn't reach appropriate level, and probably it's very different from what we see after standard IST. We studied the reconstitution of memory T-cells on day of engraftment (WBC>1000 cells\us) after allogenic hematopoietic stem cell transplantation (allo-HSCT) with post-transplant-CY and standard immunosuppression therapy. Patients and methods. During 2 years, 29 patients with different he

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8

Klingemann, HG, MS Tsoi, and R. Storb. "Inhibition of prostaglandin E2 restores defective lymphocyte proliferation and cell-mediated lympholysis in recipients after allogeneic marrow grafting." Blood 68, no. 1 (1986): 102–7. http://dx.doi.org/10.1182/blood.v68.1.102.102.

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Abstract Prostaglandins are said to influence T and B cell function by inhibiting the generation of interleukin 2 (IL 2) and the formation of suppressor lymphocytes. After bone marrow transplantation, patients usually have a profound immunodeficiency that persists in recipients with chronic graft-v-host disease (GVHD) and generally resolves in long- term survivors without GVHD. In vitro tests of lymphocyte function such as allogeneic mixed lymphocyte culture (MLC) and cell-mediated lympholysis (CML) have been shown to be impaired in many patients. We postulated that prostaglandin E2 (PGE2) pla

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9

Klingemann, HG, MS Tsoi, and R. Storb. "Inhibition of prostaglandin E2 restores defective lymphocyte proliferation and cell-mediated lympholysis in recipients after allogeneic marrow grafting." Blood 68, no. 1 (1986): 102–7. http://dx.doi.org/10.1182/blood.v68.1.102.bloodjournal681102.

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Prostaglandins are said to influence T and B cell function by inhibiting the generation of interleukin 2 (IL 2) and the formation of suppressor lymphocytes. After bone marrow transplantation, patients usually have a profound immunodeficiency that persists in recipients with chronic graft-v-host disease (GVHD) and generally resolves in long- term survivors without GVHD. In vitro tests of lymphocyte function such as allogeneic mixed lymphocyte culture (MLC) and cell-mediated lympholysis (CML) have been shown to be impaired in many patients. We postulated that prostaglandin E2 (PGE2) plays a role

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10

Sanchez., Diana, Rosana Pelayo, Rosa Elena Sarmiento, et al. "In Vitro and in Vivo oncolytic Activity of Lasota Strain of Newcastle Disease Virus on a Lymphoma B-Cell Line and a Canine Cutaneous T-Cell Lymphoma." Blood 124, no. 21 (2014): 5504. http://dx.doi.org/10.1182/blood.v124.21.5504.5504.

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Abstract Oncolytic viruses, either naturally or genetically modified, possess the ability to kill cancer cells. Newcastle Disease Virus (NDV), a type I avian paramyxovirus, has demonstrated a selective ability to kill cancer cells directly as well as through immunostimulation. NDV is able to infect more than 250 species of birds, particularly poultry and is considered a zoonosis, primarily causing conjunctivitis. Importantly, no infections have been reported in mammalian species nor is there evidence of human to human transmission. We use the LaSota strain which is lentogenic (less pathogenic)

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11

GAUTAM, S. C., and J. R. BATTISTO. "Suppression of Hapten-Specific Cell-Mediated Lympholysis by Oral Administration of Hapten Is Reversed in Vitro by Normal Helper T Cells or Helper Factors." Annals of the New York Academy of Sciences 532, no. 1 Cytotoxic T C (1988): 416–18. http://dx.doi.org/10.1111/j.1749-6632.1988.tb36360.x.

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12

Marijt, W. A., W. F. Veenhof, A. Brand, et al. "Minor histocompatibility antigen-specific cytotoxic T cell lines, capable of lysing human hematopoietic progenitor cells, can be generated in vitro by stimulation with HLA-identical bone marrow cells." Journal of Experimental Medicine 173, no. 1 (1991): 101–9. http://dx.doi.org/10.1084/jem.173.1.101.

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Recipient-antidonor alloreactivity before HLA genotypically identical bone marrow transplantation (BMT) between donor-recipient pairs that are negative in the mixed lymphocyte reaction (MLR), the cell-mediated lympholysis (CML) assay, and the lymphocyte crossmatch was not detectable in the majority of cases, using recipient peripheral blood lymphocytes (PBL) collected before BMT as responder cells and donor PBL as stimulator cells. However, when donor bone marrow mononuclear cells (BMMNC) instead of PBL were used as stimulator cells, we could detect donor-specific alloreactivity in 7 of 10 HLA

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13

Ildstad, S. T., S. M. Wren, J. A. Bluestone, S. A. Barbieri, and D. H. Sachs. "Characterization of mixed allogeneic chimeras. Immunocompetence, in vitro reactivity, and genetic specificity of tolerance." Journal of Experimental Medicine 162, no. 1 (1985): 231–44. http://dx.doi.org/10.1084/jem.162.1.231.

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Mixed allogeneically reconstituted mice (B10 + B10.D2----B10) that specifically accept B10.D2 tail skin allografts were examined for in vivo and in vitro immunocompetence, patterns of hematopoietic repopulation, and in vitro reactivity. In vitro, mixed allogeneic chimeras (B10 + B10.D2----B10) manifested specific tolerance in mixed lymphocyte reactions and cell-mediated lympholysis to B10 and B10.D2 splenocytes, with normal responses to third-party (B10.BR) cells. Such chimeras were immunocompetent in B cell and helper T cell responses, as assessed by their primary plaque forming cell response

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14

Geller, RB, AH Esa, WE Beschorner, CG Frondoza, GW Santos, and AD Hess. "Successful in vitro graft-versus-tumor effect against an Ia-bearing tumor using cyclosporine-induced syngeneic graft-versus-host disease in the rat." Blood 74, no. 3 (1989): 1165–71. http://dx.doi.org/10.1182/blood.v74.3.1165.1165.

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Abstract Lethally irradiated LouM rats reconstituted with syngeneic bone marrow and then treated with cyclosporine (CsA) for 40 consecutive days following transplant developed a graft-v-host disease (GVHD)-like syndrome after CsA cessation. This model of GVHD was used to define and characterize a graft-v-tumor (GVT) effect against a syngeneic plasmacytoma CRL1662 cell line which expresses class II major histocompatibility (MHC) antigen (Ia). Nylon wool-nonadherent spleen cells from animals who developed syngeneic GVHD were capable of significant lysis against chromium-labeled tumor target cell

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15

Geller, RB, AH Esa, WE Beschorner, CG Frondoza, GW Santos, and AD Hess. "Successful in vitro graft-versus-tumor effect against an Ia-bearing tumor using cyclosporine-induced syngeneic graft-versus-host disease in the rat." Blood 74, no. 3 (1989): 1165–71. http://dx.doi.org/10.1182/blood.v74.3.1165.bloodjournal7431165.

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Lethally irradiated LouM rats reconstituted with syngeneic bone marrow and then treated with cyclosporine (CsA) for 40 consecutive days following transplant developed a graft-v-host disease (GVHD)-like syndrome after CsA cessation. This model of GVHD was used to define and characterize a graft-v-tumor (GVT) effect against a syngeneic plasmacytoma CRL1662 cell line which expresses class II major histocompatibility (MHC) antigen (Ia). Nylon wool-nonadherent spleen cells from animals who developed syngeneic GVHD were capable of significant lysis against chromium-labeled tumor target cells in a fo

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16

Lowsky, Robert, Tsuyoshi Takahashi, Yin Ping, Judith Shizuru, Robert S. Negrin, and Samuel Strober. "Non-Myeloablative Conditioning of Total Lymphoid Irradiation (TLI) and Anti-Thymocyte Globulin (ATG) Protects Against Acute GVHD Following Allogeneic Hematopoietic Cell Transplantation (HCT) but Retains Anti-Tumor Activity." Blood 104, no. 11 (2004): 433. http://dx.doi.org/10.1182/blood.v104.11.433.433.

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Abstract Separation of GVHD from graft versus tumor (GVT) reactions is critical in improving outcomes for HCT. Murine models of transplantation showed that after conditioning with repeated low doses of irradiation targeted to lymphoid tissues (TLI) are combined with ATG, regulatory natural killer (NK) T cells become the predominant T cell subset. Secretion of high levels of IL-4 by the host NK T cells protects against aGVHD following HCT. Yet tumor killing activity mediated by donor CD8+ T cells via a direct cytolytic pathway involving perforin remains intact. Thus, regulatory T cells can sepa

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17

Innerhofer, P., G. Tilz, D. Fuchs, et al. "Immunologic changes after transfusion of autologous or allogeneic buffy coat-poor versus WBC-reduced blood transfusions in patients undergoing arthroplasty.II. Activation of T cells, macrophages, and cell-mediated lympholysis." Transfusion 40, no. 7 (2000): 821–27. http://dx.doi.org/10.1046/j.1537-2995.2000.40070821.x.

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18

Dowdell, Kennichi C., Lu Lianghao, V. Koneti Rao, Thomas A. Fleisher, and Joao Bosco Oliveira. "The BH3 Mimetic, Small Molecule, ABT-737, Was Effective As Lympholytic Therapy in the MRL/lpr−/− Mouse Model of Autoimmune Lymphoproliferative Syndrome (ALPS)." Blood 118, no. 21 (2011): 695. http://dx.doi.org/10.1182/blood.v118.21.695.695.

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Abstract Abstract 695 Autoimmune Lymphoproliferative Syndrome (ALPS) is an inherited disease associated with defects of lymphocyte apoptosis leading to lymphoproliferation and autoimmunity. The majority of ALPS patients have mutations in the FAS gene. MRL/lpr−/− (lpr) mice are used as a model for ALPS and are homozygous for FAS mutations, presenting with massive lymphadenopathy and splenomegaly associated with hypergammaglobulinemia, glomerulonephritis, and expansion of a rare population of TCR ab+CD4−CD8− (Double-negative, DN) T cells that are characteristic of ALPS. Currently, there are no p

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19

Leventhal, Joseph, Michael Abecassis, Joshua Miller, et al. "Chimerism and Tolerance Without Gvhd In Mismatched Recipients Of Combined Hematopoietic Stem Cell/Kidney Transplants: Donor-Specific Hyporeactivity Is Not a Reliable Biomarker For Tolerance." Blood 122, no. 21 (2013): 912. http://dx.doi.org/10.1182/blood.v122.21.912.912.

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Abstract We recently reported that low-intensity conditioning combined with facilitating cell (FC)-enriched hematopoietic stem cell transplantation (FCRx) can safely achieve high levels of durable chimerism in unrelated and related mismatched kidney transplant (KTx) recipients. This is associated with stable renal function, complete absence of GHVD, and successful withdrawal of immunosuppression (IS). We herein present interim follow-up of now 19 subjects and present data to demonstrate that donor specific hypoactivity does not correlate with tolerance to the renal allograft if chimerism is no

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20

Ideta, A., Y. Nakamura, K. Tsuchiya, et al. "114 BOVINE EMBRYO-MATERNAL RECOGNITION MAY OCCUR EARLIER IN AI THAN IN EMBRYO TRANSFER (ET)." Reproduction, Fertility and Development 23, no. 1 (2011): 162. http://dx.doi.org/10.1071/rdv23n1ab114.

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Embryo-maternal recognition is known to be mediated by the trophoblast and/or its secretory product during the preimplantation period. However, it was recently proposed that embryo-maternal recognition (along with the maternal immune system) could be activated by zona pellucida-degradation products including oligosaccharide chains from very early stage embryos (Fujiwara et al. 2009 J. Reprod. Immunol. 81, 1–8). If this is true, we predict that mammalian mothers recognise the presence of an embryo immediately after fertilization in vivo. The purpose of the present study was to compare the expre

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21

Zider, Laura A., Amanda N. Seddon, Sunita Nathan, John J. Maciejewski, Jamile M. Shammo, and Gorgun Akpek. "Extended Duration of Anti-Thymocyte Globulin (ATG) Administration May Reduce the Risk of Graft-Versus-Host Disease in Patients with Aplastic Anemia Undergoing Matched-Related Allogeneic Peripheral Blood Stem Cell Transplantation." Blood 128, no. 22 (2016): 5876. http://dx.doi.org/10.1182/blood.v128.22.5876.5876.

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Abstract Bone marrow is the preferred stem cell source for allogeneic transplantation in the treatment of severe aplastic anemia (AA) due to a higher risk of GVHD associated with peripheral blood stem cell allografting. Higher doses or longer durations of administration of lympholytic agents such as antithymocyte globulin (ATG) or alemtuzumab may prevent GVHD and reduce graft failure rate. We treated a 19 y/o AA woman with transfusion and antibiotic dependent severe AA associated with a small PNH clone using 12/12 HLA-match allogeneic peripheral blood stem cells (allo-PBSCT) from her brother.

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22

Dowdell, Kennichi C., Lesley Pesnicak, Victoria Hoffman, et al. "Valproic Acid (VPA), a Histone Deacetylase (HDAC) Inhibitor, Diminishes Lymphoproliferation in the Fas Deficient MRL/lpr−/− Murine Model of Autoimmune Lymphoproliferative Syndrome (ALPS)." Blood 108, no. 11 (2006): 2497. http://dx.doi.org/10.1182/blood.v108.11.2497.2497.

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Abstract ALPS is an inherited disorder of apoptosis leading to lymphoproliferation and autoimmunity. ALPS Type Ia, Ib and II are associated with germline mutations in Fas, FasL and Casapase 8 or 10, respectively; patients in whom no mutations have been identified are classified as Type III. The vast majority of patients are ALPS Type Ia (greater than 70%). They often present with childhood onset autoimmune cytopenias associated with lymphadenopathy, splenomegaly, increased double negative T cells (DNT; TCRα/β+CD3+CD4−CD8−), defective apoptosis by in vitro assay, and have an increased risk of l

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23

Dowdell, Kennichi C., Lesley Pesnicak, Lilia Bi, Victoria Hoffmann, V. Koneti Rao, and Stephen E. Straus. "Hydroxychloroquine Diminishes Lymphoproliferation in the Fas Deficient MRL/lpr−/− Murine Model of Autoimmune Lymphoproliferative Syndrome (ALPS)." Blood 110, no. 11 (2007): 1385. http://dx.doi.org/10.1182/blood.v110.11.1385.1385.

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Abstract Hydroxychloroquine (HCQ) is an anti-malarial drug in clinical use for decades that is finding further use as a steroid sparing agent in the treatment of immune disorders such as chronic GVHD, lupus and rheumatoid arthritis. HCQ is a lysosomotropic agent with more recent evidence showing immunomodulatory anti-TNF activity. It is currently being explored as a cytotoxic antineoplastic/antimicrobial agent. Hence, studies were conducted to determine the efficacy of HCQ to control the lymphoproliferation associated with ALPS. ALPS is an inherited disorder of apoptosis leading to lymphoproli

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24

Bernasconi, Paolo, Irene Dambruoso, Manuel Gotti, et al. "Do Leukemic Cells and Mesenchymal Stem Cells (MSCs) From AML Patients Share The Same Chromosomal Defect? A Cytogenetics, FISH and aCGH/Snpa Study." Blood 122, no. 21 (2013): 2602. http://dx.doi.org/10.1182/blood.v122.21.2602.2602.

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Abstract Recent evidence suggests that leukemia is not solely a cancer autonomous process, but rather a disease in which the bone marrow microenvironment, the niche, plays a crucial role too (Raaijmakers, 2011). MSCs are key component of the niche. Thus, several studies have tested whether these cells from haematological patients contain chromosomal defects identical or different from those present in leukemic cells. Based on these findings the principal aim of the present study was to evaluate whether leukemic and MSC from six AML patients shared the same cytogenetic defects after examination

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25

Claeys, Elisa, Eva Pauwels, Stephanie Humblet-Baron, et al. "Small Molecule Cyclotriazadisulfonamide Abrogates the Upregulation of the Human Receptors CD4 and 4-1BB and Suppresses In Vitro Activation and Proliferation of T Lymphocytes." Frontiers in Immunology 12 (April 21, 2021). http://dx.doi.org/10.3389/fimmu.2021.650731.

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The small molecule cyclotriazadisulfonamide (CADA) down-modulates the human CD4 receptor, an important factor in T cell activation. Here, we addressed the immunosuppressive potential of CADA using different activation models. CADA inhibited lymphocyte proliferation with low cellular toxicity in a mixed lymphocyte reaction, and when human PBMCs were stimulated with CD3/CD28 beads, phytohemagglutinin or anti-CD3 antibodies. The immunosuppressive effect of CADA involved both CD4+ and CD8+ T cells but was, surprisingly, most prominent in the CD8+ T cell subpopulation where it inhibited cell-mediat

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