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Dissertations / Theses on the topic 'Lymphoma/pathology'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Wong, Kah-Keng. "Validation of lymphoma-associated antigens identified using autoantibody profiling and protein arrays." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:51ac6bbe-2845-43cc-9b7a-cb92097155f1.

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Diffuse large B-cell lymphoma (DLBCL) is an aggressive lymphoma subtype with heterogeneous clinical outcome and a significant number of patients still die of their disease. Characterising lymphoma patients’ autoantibody repertoires represent one approach to improve the understanding of their disease biology. Our hypothesis was that characterisation of antigens eliciting humoural immune responses in lymphoma patients may provide insights into mechanisms of lymphomagenesis and identify novel diagnostic/therapeutic targets. HIP1R was validated as a novel B-NHL autoantigen by immunoblotting with p

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2

Jordan, Richard Charles Kennedy. "The molecular pathology of Sjogren's syndrome : applications to the prediction of early lymphoma." Thesis, University College London (University of London), 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.261759.

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3

Kohart, Nicole Ann Kohart. "Models, Mechanisms, and Treatment of Adult T-cell Leukemia/Lymphoma Bone Metastasis." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1503248777003095.

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4

Tustin, Richard. "An immunohistochemical analysis of Hodgkin's disease and anaplastic large cell lymphoma using antibodies effective in paraffin sections." Master's thesis, University of Cape Town, 1992. http://hdl.handle.net/11427/26334.

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5

Fischer, Marie. "Mast cells in Hodgkin lymphoma : or 'What's a nice cell like you doing in a tumour like this?'." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.bibl. [distributör], 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4620.

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6

Kusuke, Natália Shizu. "Avaliação das características clínicas e imuno-histoquímicas dos linfomas intraorais diagnosticados no Serviço de Patologia Cirúrgica da FOUSP." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/23/23154/tde-15082018-092932/.

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Linfoma é uma neoplasia maligna originária dos linfócitos. Podem atingir regiões nodais e extranodais, este último ocorrendo mais comumente em casos de linfoma não-Hodking (LNH) e raramente em linfomas de Hodking (LH). Na cavidade oral, o linfoma é classificado como a terceira neoplasia mais comumente encontrada depois do Carcinoma epidermóide e tumores de glândula salivar. O linfoma difuso de grandes células B (LDGCB) é o subtipo mais comum de LNH na cavidade oral, e ocorre mais comumente em região do palato e gengiva marginal. O diagnóstico do linfoma requer um estudo imuno-histoquímico, inc

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7

Baumann, Ursula [Verfasser], Florian [Akademischer Betreuer] [Gutachter] Bassermann, Bernhard [Gutachter] Küster, and Claus [Gutachter] Belka. "The role of the ubiquitin-proteasome system in the pathology and treatment of B-cell lymphoma : Characterization of the PRKCD-FBXO25-HAX1 axis in lymphomagenesis and treatment resistance of B-cell lymphoma / Ursula Baumann ; Gutachter: Bernhard Küster, Claus Belka, Florian Bassermann ; Betreuer: Florian Bassermann." München : Universitätsbibliothek der TU München, 2017. http://d-nb.info/1137010452/34.

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8

Kaymaz, Yasin. "Genomic and Transcriptomic Investigation of Endemic Burkitt Lymphoma and Epstein Barr Virus." eScholarship@UMMS, 2017. https://escholarship.umassmed.edu/gsbs_diss/914.

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Endemic Burkitt lymphoma (eBL) is the most common pediatric cancer in malaria-endemic equatorial Africa and nearly always contains Epstein-Barr virus (EBV), unlike sporadic Burkitt Lymphoma (sBL) that occurs with a lower incidence in developed countries. Despite this increased burden the study of eBL has lagged. Additionally, while EBV was isolated from an African Burkitt lymphoma tumor 50 years ago, however, the impact of viral variation in oncogenesis is just beginning to be fully explored. In my thesis research, I focused on investigating molecular genetics of the endemic form of this lymph

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9

Kaymaz, Yasin. "Genomic and Transcriptomic Investigation of Endemic Burkitt Lymphoma and Epstein Barr Virus." eScholarship@UMMS, 2007. http://escholarship.umassmed.edu/gsbs_diss/914.

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Endemic Burkitt lymphoma (eBL) is the most common pediatric cancer in malaria-endemic equatorial Africa and nearly always contains Epstein-Barr virus (EBV), unlike sporadic Burkitt Lymphoma (sBL) that occurs with a lower incidence in developed countries. Despite this increased burden the study of eBL has lagged. Additionally, while EBV was isolated from an African Burkitt lymphoma tumor 50 years ago, however, the impact of viral variation in oncogenesis is just beginning to be fully explored. In my thesis research, I focused on investigating molecular genetics of the endemic form of this lymph

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10

Bedoya, Felipe. "Identification and Characterization of Mitochondrial Genome Concatemers in AIDS-Associated Lymphomas and Lymphoma Cell Lines." [Tampa, Fla] : University of South Florida, 2009. http://purl.fcla.edu/usf/dc/et/SFE0003030.

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11

Heidari, Ramesh. "Immunoglobulin VH gen analys in human B-cell." Thesis, Uppsala University, Department of Medical Biochemistry and Microbiology, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7392.

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<p>Malt lymphoma is a malignant disease that can arise in a variety of extra nodal sites. Previous studies indicate that tumour arise from more mature B-cells.</p><p>Our purpose was to examine the presence of clonality and somatic hypermutation of immunoglobulin (IgVн) of MALT lymphomas.</p><p>Paraffin-embedded tumour samples from13 MALT lymphoma were subjected to rearrangement analysis, by using PCR, heteroduplex gels and sequence analysis.</p><p>Successful amplification was seen in 10/13 cases and sequences of IgVн genes were obtained in 6/13, all of them were mutated. The percentage of muta

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12

Munier-Bousseton, Fabienne. "Neuroblastome, résistance in vivo à l'irinotecan et voie de signalisation ALK." Phd thesis, Université Paris Sud - Paris XI, 2012. http://tel.archives-ouvertes.fr/tel-00829102.

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Les neuroblastomes, même de haut risque répondent bien à la chimiothérapie initiale mais deviendront fréquemment résistants au traitement. Les inhibiteurs de topoisomérase I représentent un outil thérapeutique important dans la prise en charge des neuroblastomes réfractaires. Pour étudier la résistance aux inhibiteurs de topoisomérase I acquise dans un contexte thérapeutique, un modèle murin de neuroblastome résistant au CPT-11 a été développé. La chimiorésistance est connue comme un phénomène multifacoriel. Nous avons donc utilisé plusieurs approches pour mieux caractériser les mécanismes à l

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13

Alves, de Souza Rios Leonardo. "Understanding the molecular pathogenesis of HIV-associated Burkitt Lymphoma – the impact of HIV-1 protein Tat on lymphoma driver genes." Doctoral thesis, Faculty of Health Sciences, 2021. http://hdl.handle.net/11427/33627.

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Burkitt Lymphoma (BL) is a B cell non-Hodgkin lymphoma that occurs as three distinct subtypes, namely: endemic, sporadic, and immunodeficiency/HIV-associated. This cancer represents a frequent cause of mortality among HIV+ people in Southern Africa which has the highest incidence of HIV/AIDS worldwide. Recent reports associate a direct oncogenic function of HIV in BL development. However, the molecular mechanisms underlying this HIV-associated malignancy are not well understood. This study explores the oncogenic potential of HIV-1 protein Tat in BL via its ability to manipulate the expression

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14

Antel, Katherine Rae. "Lymphoma: Understanding the diagnostic challenges and improving outcomes in a TBand HIV-endemic area." Doctoral thesis, Faculty of Health Sciences, 2021. http://hdl.handle.net/11427/33628.

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Background and aims Diagnosing lymphoma can be challenging: even in the best-resourced settings, lymphoma diagnosis may be delayed owing to the insidious onset of symptoms and/or difficulties in obtaining lymph node biopsy for diagnosis. In TB-endemic countries the diagnostic challenges in lymphoma may be further compounded by symptoms overlapping with those of TB and by resource limitations that may impede obtaining a diagnostic biopsy. New lymphoma diagnostic modalities, including the use of nextgeneration sequencing, are evolving rapidly and informing both prognosis and therapy in the field

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15

Pather, Sugeshnee. "Large cell lymphoma : correlation of HIV status and prognosis with differentiation profiles assessed by immunophenotyping." Master's thesis, University of Cape Town, 2011. http://hdl.handle.net/11427/10860.

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Includes abstract.<br>Includes bibliographical references (leaves 80-93).<br>The study aimed to contribute a South African perspective by correlating the HIV status and prognosis of DLBCL and PBL with differentiation profiles assessed by immunophenotyping.

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16

Ibrahim, Maha. "Contribution of tumour cell signalling and the microenvironment to the pathogenesis of EBV-associated B cell lymphoma and nasopharyngeal carcinoma." Thesis, University of Birmingham, 2018. http://etheses.bham.ac.uk//id/eprint/8099/.

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In this thesis I have explored different components of the pathogenesis of several related EBV associated cancers. In the first part of the thesis I focus on the microenvironment of two of these cancers, nasopharyngeal carcinoma (NPC) and diffuse large B cell lymphoma (DLBCL). Our group has developed a therapeutic vaccine against EBV which has already been shown to be safe in patients with NPC. Therefore, in the first results chapter (chapter 3), I present a description of the phenotyping of expression of the immune microenvironment including immune checkpoint (ICP) genes and MHC class I and c

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17

Ramorola, Beatrice Relebogile. "HIV alters the expression of miRNA hsa-miR-200c-3p in B-cells, leading to enhanced migration of lymphoma cells." Master's thesis, University of Cape Town, 2018. http://hdl.handle.net/11427/29178.

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Background: The sub-Saharan African region is one that is affected most by the HIV/AIDS pandemic, with South Africa being the country with the highest number of infected individuals at 7.06 million. Infection with HIV is often associated with co-morbidities, including HIV-associated Non-Hodgkin’s Lymphomas (HIV-NHLs). Burkitt’s lymphoma (BL), a highly aggressive cancer, is one of the most common NHLs associated with HIV infection. Despite receiving highly active anti-retroviral therapy, the prognosis for this HIV-associated lymphoma remains poor and the incidence keeps on increasing in this gr

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18

Wilson, Katherine Sarah. "The pathogenesis of classical Hodgkin lymphoma : investigation of possible viral pathogens and recurrent chromosomal imbalances." Thesis, University of Glasgow, 2008. http://theses.gla.ac.uk/488/.

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Hodgkin lymphoma (HL) is a malignant lymphoma that is diagnosed mostly in young adults, and is the second most common malignancy to affect this age group. This disease is subdivided into two entities with different aetiologies: classical HL (cHL) (~95% of cases) and nodular lymphocyte-predominant HL. In Europe, ~82% of young adults with cHL are non-Epstein-Barr virus associated and epidemiological studies have suggested that a common infectious agent may play a key role in the aetiology of these cases. The molecular biology of HL is not well understood, primarily due to the low number of Hodgk

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19

Vernersson, Lindahl Emma. "Investigating the function of Anaplastic Lymphoma Kinase." Doctoral thesis, Umeå : Univ, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1956.

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20

Edginton-White, Benjamin. "The role of aberrant transcription factor expression and loss of epigenetic control in activating long-terminal-repeats in Hodgkin's lymphoma." Thesis, University of Birmingham, 2018. http://etheses.bham.ac.uk//id/eprint/8166/.

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Long terminal repeat (LTR) elements are wide-spread in the human genome and have the potential to act as alternative promoters and enhancers. Their expression is therefore under tight epigenetic control. We previously reported that a member of a specific class ofLTR elements (THE I B) in Hodgkin's Lymphoma (HL) acted as a promoter for the growth factor receptor gene CSF 1 R and that this gene is required for HL cell survival. However, to which extent and how such elements participate in shaping the unique gene expression program of HL is unknown. To address this question we mapped the genome-w

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21

Margielewska, Sandra Karolina. "The contribution of discoidin domain receptor 1 to the pathogenesis of diffuse large B cell lymphoma." Thesis, University of Birmingham, 2018. http://etheses.bham.ac.uk//id/eprint/8421/.

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Collagen is the ligand for the discoidin domain receptor-1 (DDR1), a receptor tyrosine kinase that is over-expressed in Hodgkin lymphoma. However, the role of DDR1 in diffuse large B cell lymphoma (DLBCL) is not known. I showed that DDR1 is over-expressed in a subset of DLBCL where it positively correlates with expression of its collagen ligands, and negatively correlates with expression of mitotic spindle genes. DDR1 correlated genes also overlapped with three aneuploidy signatures and DDR1 expression correlated significantly with autosomal aneuploidy index. RNAseq analysis revealed that over

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22

Levy, Blitchtein Saul, Rebata Stefany Plasencia, Domingo Morales Luna, and Valle Mendoza Juana Del. "Coexistence of papillary thyroid microcarcinoma and mucosa-associated lymphoid tissue lymphoma in a context of Hashimoto’s thyroiditis." Elsevier B.V, 2016. http://hdl.handle.net/10757/615646.

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Papillary thyroid cancer (PTC) represents 80%-85% of thyroid cancer and its prevalence has been rising in the last decades. Primary thyroid lymphoma (PTL) accounts for 3% of extranodal lymphomas and about 5% of thyroid malignancies, having a prevalence of one or two cases per million people. Mucosa-Associated Lymphoid Tissue lymphoma represents approximately 30% of PTL. Both entities have an indolent course and a very good prognosis. Diagnosis is made by ultrasound and fine needle aspiration (FNA) or surgery specimen pathology. They have also been associated with HT, but pathogenesis and its l

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23

Darini, Elaine. ""Colonização gástrica por Helicobacter pylori associada à citotoxina do gene A (cagA): relação com proliferação celular e apoptose"." Universidade de São Paulo, 2004. http://www.teses.usp.br/teses/disponiveis/5/5160/tde-08082005-153835/.

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HP, uma bactéria gram-negativa envolvida na patogênese do tecido gastroduodenal, foi classificada como carcinogênico classe I em 1994. Seus mecanismos são pouco entendidos, mas a presença da ilha de patogenicidade (PAI) é fator importante de virulência. PAI sugere aumento da proliferação celular, diminuindo a apoptose. A detecção do HP e da PAI (cagA) foi feita por PCR. Casos positivos são associados aos resultados histopatológicos, proliferação celular e apoptose. Detectamos HP em 37,0% (111/300), sendo 40,5% (45/111) dos pacientes cagA+. A relação proliferação celular/apoptose (P/A) mostra a

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24

Albero, Gallego Robert. "Mantle cell lymphoma pathogenesis: another turn of the screw to cyclin D1 overexpression." Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/565574.

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Mantle cell lymphoma (MCL) is an aggressive lymphoid neoplasm derived from mature B cells characterized by the presence of the t(11;14)(q13;q32) translocation that leads to the overexpression of Cyclin D1. Cyclin D1 plays a well-established role in G1/S progression, although other functions including transcription or DNA damage response (DDR) can be regulated by this cyclin. Therefore, the main goal of this thesis is the characterization of the cyclin D1 non-canonical function in MCL and lymphoid cells. Firstly, we analyzed the genomic binding of endogenous cyclin D1 in four MCL cell lines

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25

Broutier, Laura. "Implication du contrôle apoptotique exercé par les couples nétrine-1 et ses récepteurs à dépendance (DCC et UNC5B) au cours du développement embryonnaire et de la tumorigenèse : la signalisation apoptotique des récepteurs à dépendance : interface entre physiologie et pathologie." Phd thesis, Université Claude Bernard - Lyon I, 2014. http://tel.archives-ouvertes.fr/tel-01058216.

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Les récepteurs à dépendance présentent la particularité d'induire deux voies de signalisation différentes selon la disponibilité de leur ligand. En présence de leur ligand, ils transduisent une voie de signalisation favorisant notamment la survie cellulaire (signalisation positive), tandis qu'en son absence, ils induisent activement l'apoptose des cellules (signalisation négative). La dualité fonctionnelle de ces récepteurs pourrait leur conférer un rôle central au cours du développement embryonnaire, mais aussi dans le maintien de l'homéostasie cellulaire chez l'adulte. En effet, du fait de l

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26

Ogbe, Ane Theodora. "Early Growth Response genes 2 and 3 play a role in chronic inflammation pathology and are essential for the differentiation of T follicular helper cells." Thesis, Brunel University, 2015. http://bura.brunel.ac.uk/handle/2438/11214.

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The Early Growth Response genes 2 and 3 (Egr2/3) are zinc finger transcription factors that play an important role in the immune system. These transcription factors have reported functions in T cell receptor signaling, differentiation of effector T cell subsets and the development of lupus-like autoimmune diseases. Using CD2-Egr2-/- Egr3-/- mouse model, I investigate the development of inflammation pathology, differentiation of T follicular helper (Tfh) cells and the formation of germinal centers (GC) following viral challenge within these mice. The onset of inflammation pathology in CD2-Egr2-

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27

Huang, Wei. "Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CaMKK2) Regulates Dendritic Cells and Myeloid Derived Suppressor Cells Development in the Lymphoma Microenvironment." Diss., 2016. http://hdl.handle.net/10161/12171.

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<p>Calcium (Ca2+) is a known important second messenger. Calcium/Calmodulin (CaM) dependent protein kinase kinase 2 (CaMKK2) is a crucial kinase in the calcium signaling cascade. Activated by Ca2+/CaM, CaMKK2 can phosphorylate other CaM kinases and AMP-activated protein kinase (AMPK) to regulate cell differentiation, energy balance, metabolism and inflammation. Outside of the brain, CaMKK2 can only be detected in hematopoietic stem cells and progenitors, and in the subsets of mature myeloid cells. CaMKK2 has been noted to facilitate tumor cell proliferation in prostate cancer, breast cancer, a

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28

Stephenson, Tamsyn. "Pathology, coinfections and oncogenesis in South Australian koalas (Phascolarctos cinereus) and their association with koala retrovirus (KoRV)." Thesis, 2021. https://hdl.handle.net/2440/134187.

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Koalas are a vulnerable iconic species, for which disease is a significant threat to populations around Australia. Lymphoid neoplasia and immunomodulation in koalas have been associated with an important pathogen, koala retrovirus (KoRV). The prevalence and transmission of KoRV differs in northern koalas, from Queensland and New South Wales, compared to southern koalas, from Victoria and South Australia. Northern koalas inherit and horizontally transmit KoRV via endogenous and exogenous mechanisms, respectively with all koalas infected. Southern koalas are hypothesised to only have exogenous t

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29

Matos, Cristiana Patrícia Lajas. "Mecanismos moleculares envolvidos na fisiopatologia de alguns Linfomas de células T Periféricos." Master's thesis, 2021. http://hdl.handle.net/10316/98583.

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Trabalho Final do Mestrado Integrado em Medicina apresentado à Faculdade de Medicina<br>O linfoma de células T periférico (PTCL) corresponde a 10-15% de todos os Linfomas não Hodgkin (LNH) e é muito heterogéneo na apresentação clínica e no perfil de alterações moleculares. A revisão da classificação das neoplasias linfoides da Organização Mundial da Saúde (OMS) de 2016 distingue 29 entidades de PTCL, baseando-se em estudos recentes de sequenciação génica e numa melhor compreensão da célula de origem. No entanto, 30-50% dos PTCL são classificados em PTCL,not otherwised specified (NOS) por não c

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30

Fajardo, Muñoz Raul Cuauhtémoc. "Exploration pathologique des souris transgéniques porteuses du gène VPU de VIH-1." Thèse, 2011. http://hdl.handle.net/1866/5289.

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L‟infection par le VIH-1, chez les patients, affecte principalement le système immunitaire et conduit à une destruction graduelle des lymphocytes T CD4 et, par conséquent, entraîne un état d‟immunodéficience. Cette immunodéficience permet l'établissement d‟infections opportunistes qui sont responsables de manifestations cliniques associées au Sida. Ces patients peuvent aussi développer des lymphomes, lésions du système nerveux central et une atteinte rénale. L'ampleur et la sévérité des conditions associées observées chez les patients infectés par le VIH-1 ne peuvent être imputées seulement au

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31

"Transcriptome Analysis Of Lymphoma Associated Viruses And Analysis Of Viral Noncoding Rnas." 2014.

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32

Bischof, Daniela. "The role of nucleophosmin fusion sequences in the oncogenic activation of the (2;5) translocation protein, nucleophosmin-anaplastic lymphoma kinase (NPM-ALK)." Thesis, 1996. http://hdl.handle.net/10539/20829.

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A thesis submitted to the Faculty of Science, University of the Witwatersrand, Johannesburg, South Africa, in fulfillment of the requirements for the degree of Doctor of Philosophy. Johannesburg, 1996<br>The NPM-ALK fusion gene, formed by the t(2;5)(p23;q35) in non-Hodgkin's lymphoma encodes a 75kDa hybrid protein that contains the amino-terminal 118 amino acid residues of the nucleolar phosphoprotein nucleophosmin (NPM) joined to the entire cytoptasmic portion of the receptor tyrosine kinase, anaplastic lymphoma kinase (ALK). The transforming ability of NPM-ALK is demonstrated and it

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