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Dissertations / Theses on the topic 'Lymphoma'

Author: Grafiati
Published: 4 June 2021
Last updated: 26 July 2025

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1

Sakakibaya, Ayako, Kumi Kawai, Tetsuro Nagasaka, et al. "Molecular diagnosis of malignant lymphoma : mantle cell lymphoma, anaplastic large cell lymphoma, and marginal zone B-cell lymphoma of malt." Nagoya University School of Medicine, 2006. http://hdl.handle.net/2237/6127.

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2

Maesako, Yoshitomo. "Comparison of gene expression profiles of lymphoma cell lines from transformed follicular lymphoma, Burkitt's lymphoma and de novo diffuse large B-cell lymphoma." Kyoto University, 2004. http://hdl.handle.net/2433/148266.

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3

D'Haene, Nicky. "Implication des galectines-1 et -3 dans l'angiogenèse et en particulier en ce qui concerne les lymphomes." Doctoral thesis, Universite Libre de Bruxelles, 2011. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209900.

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Les lymphomes sont constitués de sous-groupes tumoraux définis par différents critères cliniques, morphologiques, immunophénotypiques et moléculaires. Néanmoins, même au sein d’un sous-groupe, il existe une grande hétérogénéité dans l’évolution clinique des patients, ce qui rend leur prise en charge difficile. Ceci souligne l’importance de découvrir de nouveaux biomarqueurs pronostiques qui amélioreraient l’approche thérapeutique personnalisée. <p>La revue de la littérature fait apparaitre les galectines-1 et -3 comme des protéines impliquées dans le développement des cancers ainsi que dans la
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4

Camilleri, Emily Therese. "The Transcriptional Role of FOXP1 in Non-Hodgkin's Lymphoma." Thesis, Griffith University, 2013. http://hdl.handle.net/10072/367974.

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Non-Hodgkin's lymphoma (NHL) is a family of lymphoid malignances that are the 6th leading cause of death in Australia. B cell lymhomas account for approximately 90% of all NHL cases, and the common subtypes Diffuse Large B cell Lymphoma (DLBCL) and Follicular Lymphoma (FL) together make uo 60% of all cases. DLBCL and FL are both germinal centre derived B cell lymphomas, however these malignancies represent opposite ends of the clinical scale, being aggressive compared to indolent disease respectively. Early detection of lymphoma is highly advantageous for aggressive subtypes like DLBCL, where
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5

Virginia, Mancini. "The Lymphoma Microenviroment." Doctoral thesis, Università di Siena, 2022. http://hdl.handle.net/11365/1194259.

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The study of the microenviroment, the cellular milieau in wich the neoplastic cells thrive, represents a relevant focus of investigation in order to explore potential targets for immunotherapy. Using immunohistochemistry tecnique, we analyzed the lymphoma microenviroment in particular in sampling of Primary Testicular Diffuse Large B-cells Lymphoma, an aggressive lymphoma for wich few therapeutic strategies are available.
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6

Sharma, Purva, Bahaaeldin Youssef, Sakshi Singal, and Devapiran Jaishankar. "In Situ Follicular Neoplasia yet another Spectrum That Extends From Normalcy to Overt Malignancy." Digital Commons @ East Tennessee State University, 2020. https://dc.etsu.edu/asrf/2020/presentations/28.

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In situ follicular neoplasia (ISFN) is defined as a monoclonal proliferation of B cells with immunophenotypic and genetic features of follicular lymphoma (FL) but confined to germinal centers of lymph nodes or other organs. It may not be associated with underlying overt lymphoma. It can be associated with lymphoproliferative disorders other than FL. A fifty-seven-year-old caucasian male initially presented with atypical chest pain, which led to cardiology evaluation. Patient underwent a coronary CT angiogram, which revealed a calcium score of 0, however also incidentally revealed mediastinal l
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7

Clothier, Stacy Lauren. "Immune Checkpoint Molecule Expression in Canine Lymphoma and Canine Reactive Lymphoid Hyperplasia." Thesis, Virginia Tech, 2019. http://hdl.handle.net/10919/103200.

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Background: Although lymphoma is one of the most common malignancies in dogs, remission rates and survival times remain stagnant. Treatment with a multi-agent chemotherapy protocol induces remission for less than one year and the majority of patients relapse. Fewer than 25% of dogs live longer than two years with the currently available treatments. Targeted immunotherapy using checkpoint molecule blockade of PD-1 and PD-L1 shows promise for various types of human cancer, including relapsed/refractory lymphoma; however, little is known regarding the role of these checkpoint molecules in canine
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8

FANGAZIO, MARCO. "Molecular Determinants of Follicular Lymphoma Transformation to Diffuse Large B cell Lymphoma." Doctoral thesis, Università del Piemonte Orientale, 2014. http://hdl.handle.net/11579/46568.

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9

Amini, Rose-Marie. "Hodgkin Lymphoma : Studies of Advanced Stages, Relapses and the Relation to Non-Hodgkin Lymphomas." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2002. http://publications.uu.se/theses/91-554-5265-5/.

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10

Majeed, Aneela, Onyee Chan, Onyemaechi Okolo, Volodymyr Shponka, Anca Georgescu, and Daniel Persky. "Hodgkin Lymphoma Mimicking Osteomyelitis." KARGER, 2017. http://hdl.handle.net/10150/625840.

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Hodgkin lymphoma with symptomatic osseous involvement can have a similar presentation to osteomyelitis. Common findings in symptoms, laboratory workup, and imaging can make it very difficult to distinguish between the two diseases. Excisional biopsy should be pursued if fine-needle biopsy is equivocal and suspicion of lymphoma is high. We report a case of a 40-year-old man who presented with a history of marine animal sting on his neck and later developed erythema in the area, chest pain, constitutional symptoms, adenopathy, and imaging classic for sternal osteomyelitis. Fortunately, initial b
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11

deLeeuw, Ronald John. "Mantle cell lymphoma pathogenesis." Thesis, University of British Columbia, 2009. http://hdl.handle.net/2429/12469.

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Mantle cell lymphoma (MCL) is an aggressive non-Hodgkin’s lymphoma with a median patient survival time of 3 years. Although the characteristic t(11;14)(q13;q32) is found in virtually all cases, experimental evidence suggests that this event alone is insufficient to result in lymphoma and secondary genomic alterations are required. Therefore, secondary genetic alterations have been proposed as essential in MCL pathogenesis. Within this thesis I describe the creation of a novel assay to determine segmental copy number alterations at a previously unprecedented resolution. This new assay necessita
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12

Tian, Min. "Phospholipid metabolism in lymphoma." Thesis, University of Oxford, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.359435.

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13

Goatly, Alison. "FOXP1 abnormalities in lymphoma." Thesis, University of Cambridge, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.611626.

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14

Zimmermann, Karin. "Differential splicing in lymphoma." Doctoral thesis, Humboldt-Universität zu Berlin, 2018. http://dx.doi.org/10.18452/19385.

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Alternatives Spleißen ist ein wesentlicher Mechanismus, um Proteindiversität in Eukaryoten zu gewährleisten. Gewebespezifität sowie entwicklungsrelevante Prozesse werden unter anderem massgeblich davon beeinflusst. Aberrante (alternative) Spleißvorgänge können wiederum zu veränderten Proteinisoformen führen, die verschiedenste Krankheiten wie Krebs verursachen oder zu veränderter Medikamentenwirksamkeit beitragen können. In dieser Arbeit untersuchen wir differentielles Spleißen im Kontext von Krebserkrankungen. Dazu betrachten wir drei Aspekte, die uns wichtig erscheinen. Der erste Teil di
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15

Kaneko, Hitomi. "Introduction of OX40 ligand into lymphoma cells elicits anti-lymphoma immunity in vivo." Kyoto University, 2005. http://hdl.handle.net/2433/144771.

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16

Busson, Raphaël. "Fatigue chronique chez les survivants d'un lymphome." Thesis, Normandie, 2018. http://www.theses.fr/2018NORMC238/document.

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La progression des traitements dans le lymphome amène à s’intéresser à la qualité de vie des survivants. La fatigue chronique est le problème le plus fréquemment décrit par les survivant. Dans le cadre du lymphome hodgkinien, le niveau de fatigue revêt une importance particulière par les patients ont entre 20 et 40 ans et sont confronté aux problématiques de retour à l’emploi. Dans la première partie de cette thèse, nous traiterons des causes de la fatigue et de sont évolutions pour les lymphomes hodgkinien et les lymphomes non-hodgkinien. En particulier, nous mettrons en lumière l’impacte des
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17

Creveaux, Marion. "Implication de deux partenaires de DCC dans le développement et la tumorigenèse." Thesis, Lyon, 2016. http://www.theses.fr/2016LYSE1171.

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DCC est un récepteur transmembranaire ayant pour ligand la nétrine-1. DCC appartient à la famille des récepteurs à dépendance, qui ont la particularité de ne pas rester inactifs en absence de ligand mais, au contraire, d'induire activement l'apoptose lorsqu'ils sont dans un état non lié, ce qui explique leur fonction suppresseur de tumeur. Mon travail de thèse s'est articulé autour de deux axes de recherche: Axe 1 : Implication du couple DCC/nétrine-1 dans la lymphomagenèse. Nous avons montrer que l'expression du couple DCC/nétrine-1 est dérégulée dans les lymphomes du manteau (LM) ainsi que d
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18

Bedoya, Felipe. "Identification and Characterization of Mitochondrial Genome Concatemers in AIDS-Associated Lymphomas and Lymphoma Cell Lines." [Tampa, Fla] : University of South Florida, 2009. http://purl.fcla.edu/usf/dc/et/SFE0003030.

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19

Nardini, Elena. "Characterization of genetic events involving IgH switch regions in gastric low grade MALT lymphomas and B CLL." Thesis, Open University, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.251405.

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20

Hovhannisyan, Narinée. "[18F] Fludarabine pour l'imagerie TEP des lymphomes." Thesis, Normandie, 2018. http://www.theses.fr/2018NORMC412/document.

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Bien que l’utilité de la TEP au [18F]FDG soit confirmée pour le diagnostic et le suivi thérapeutique chez les patients atteints de lymphome, la spécificité de la captation du [18F]FDG a été mise en doute en raison de sa dépendance au métabolisme du glucose, qui peut augmenter dans des conditions bégnines comme les processus inflammatoire ou infectieux. Compte tenu de ces limites, un nucléoside a été développé en tant que nouvel outil pour l'imagerie TEP ([18F]fludarabine). Une radiosynthèse entièrement automatisée a été mise en place et des études précliniques ont été menées sur des modèles mu
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21

Escribà, Garcia Laura. "Cellular immunotherapy for B-cell lymphoma with B-cell lymphoma with NKT-cell agonists." Doctoral thesis, Universitat Autònoma de Barcelona, 2016. http://hdl.handle.net/10803/386489.

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Las células NKT representan una pequeña población de linfocitos con especificidad única para antígenos glicolipídicos, presentados por el receptor CD1d presente, principalmente, en las células dendríticas. Estas células juegan un papel muy important en la respuesta inmune antitumoral ya que coordinan tanto el sistema inmune innato como adaptativo. Las células NKT pueden ser activadas por el lípido sintético α-galactosilceramida (α-GalCer), que estimula la secreción de citoquinas como el IFN-γ, IL-12, IL-4 e IL-17, contribuyendo a la activación de células dendríticas (CDs), NK, B y T. En este t
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22

Shah, Nimish. "The biology of mantle cell lymphoma : exploring the gender difference in mantle cell lymphoma." Thesis, University of Plymouth, 2016. http://hdl.handle.net/10026.1/5333.

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Mantle cell lymphoma (MCL) is a rare B cell neoplasm that accounts for approximately 4-8% of non-Hodgkin’s lymphomas (NHLs). The median age at diagnosis is 65 years with a male to female predominance of 3:1. It has also been demonstrated that female MCL patients have a greater response to therapy, especially immunomodulatory therapy compared to male MCL patients. The concept of cancer immunosurveillance is well described and it is perceived that females mount a greater immune response compared to males. In addition, although lymphomas are generally not perceived to be hormone controlled, epide
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23

Illidge, Timothy Martin. "Radioimmunotherapy of Non-Hodgkin's Lymphoma : the interaction of radiation and antibody with lymphoma cells." Thesis, University of Southampton, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.287070.

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24

Sha, Chulin. "Burkitt lymphoma classification and MYC-associated non-Burkitt lymphoma investigation based on gene expression." Thesis, University of Leeds, 2015. http://etheses.whiterose.ac.uk/9250/.

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Burkitt lymphoma and diffuse large B-cell lymphoma are two closely related types of lymphoma that are managed differently in clinical practice and the accurate diagnosis is a key point in treatment decisions. However based on current criteria combined with morphological, immunophenotypic and genetic characteristics, a significant number of cases exhibit overlapping features where diagnosis and treatment decisions are difficult to make. Especially, the prognosis have been reported significantly unfavourable in a subset of cases that are initially diagnosed as diffuse large B-cell lymphoma but b
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25

Duc, Touyana. "Caractérisation moléculaire et sérologique de l'infection à Epstein-Barr virus chez les patients porteurs du VIH souffrant d'un lymphome." Thesis, Université Grenoble Alpes (ComUE), 2016. http://www.theses.fr/2016GREAV074.

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En 2016, les lymphoproliférations malignes [lymphome malin non hodgkinien (LNH) et lymphome de Hodgkin (LH)] restent un problème majeur chez les patients porteurs du VIH (PPVIH) car chaque année de 1 à 6 % de ces patients développent des lymphomes. Ces pathologies apparaissent actuellement comme une des principales causes de mortalité chez les PPVIH.Le virus d’Epstein-Barr (EBV), connu de longue date pour son pouvoir immortalisant des lymphocytes B et les propriétés oncogènes de certaines de ses protéines, apparait comme un cofacteur favorisant plus ou moins important de ces lymphomes chez les
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26

Bourbon, Estelle. "Developing logic-gated CAR T cells for saferT-cell lymphoma therapy." Electronic Thesis or Diss., université Paris-Saclay, 2025. http://www.theses.fr/2025UPASL006.

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La thérapie par cellules T à récepteur antigénique chimérique (CAR) est apparue comme l'une des percées les plus convaincantes dans le traitement du cancer au cours de la dernière décennie. Cependant, les résultats remarquables obtenus dans les hémopathies B ne se sont pas encore étendus aux lymphomes T (LT) où l'éventuelle toxicité « on-target off-tumor » a limité le développement d'approches similaires.Dans ce travail, nous avons développé une plateforme NOT-gate, tirant parti de la perte d'expression du CD7 dans les LT pour distinguer les cellules T tumorales des cellules T normales. Cette
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27

ROMA, STEFANIA. "ROLE AND REGULATION OF HUMAN INNATE LYMPHOID CELLS AND NATURAL KILLER CELLS IN LYMPHOMA." Doctoral thesis, Università degli Studi di Milano, 2021. http://hdl.handle.net/2434/884399.

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Innate immune system can be helpful or harmful in cancer regression depending on tumor microenvironment. Innate lymphoid cells are constituents of innate immune system with helper innate lymphoid cells (ILCs) that are mainly tissue-resident lymphocytes and natural killer cells (NK) that are pro-inflammatory cells displaying cytotoxic activity. In our project, we explored the role and regulation of helper ILCs and NK cells in B-cell non-Hodgkin lymphoma and Hodgkin lymphoma, hematologic malignancies derived from B-lymphocytes. We found that in peripheral blood of non-Hodgkin lymphoma patients,
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28

Hamoudi, Rifat A. "Molecular pathogenesis of MALT lymphoma." Thesis, University of Cambridge, 2010. https://www.repository.cam.ac.uk/handle/1810/238398.

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Mucosa associated lymphoid tissue (MALT) lymphoma is characterized by t(11;18)(q21;q21)/API2-MALT1, t(1;14)(p22;q32)/BCL10-IGH andt(14;18)(q32;q21)/IGH-MALT1, which commonly activate the NF-κB pathway. Gastric MALT lymphomas harbouring such translocation do not respond to Helicobacter pylori eradication, while those without translocation can be cured by antibiotics. To understand the molecular mechanism of MALT lymphoma with and without chromosome translocation, 24 cases (15 translocation-positive and 9 translocation-negative) of MALT lymphomas together with 7 follicular lymphomas and 7 mantle
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29

Davison, Andrew Paul. "Phospholipid metabolism in hepatic lymphoma." Thesis, University of Oxford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325624.

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30

Ó, Riain Ciarán Liam. "DNA methylation in follicular lymphoma." Thesis, Queen Mary, University of London, 2010. http://qmro.qmul.ac.uk/xmlui/handle/123456789/1318.

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Follicular Lymphoma (FL) is a common B cell Non-Hodgkin Lymphoma with a median survival of 8-10 years. Patients frequently undergo transformation to a more aggressive lymphoma and this is associated with drastically reduced survival. The hallmark of FL is the t(14;18) translocation yet this alone is insufficient for lymphomagenesis. While a number of secondary genetic changes have been described, epigenetic studies have lagged behind. Epigenetics refers to mechanisms that alter gene expression without a change in the primary DNA sequence. DNA methylation was quantitatively profiled at 1505 CpG
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31

Delforoush, Maryam. "Potential New Drugs in Lymphoma." Doctoral thesis, Uppsala universitet, Institutionen för immunologi, genetik och patologi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-280546.

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Lymphomas are malignant tumours arising from cells in the lymphatic system. They are classified as B-cell lymphomas, T-cell lymphomas and Hodgkin lymphoma (HL). Of the B-cell lymphomas, one of the most common is diffuse large B-cell lymphoma (DLBCL). Many patients with lymphomas can be successfully treated however patients who relapse or are refractory have a poor prognosis, warranting further investigations to identify potential targets and develop novel drugs. Picropodophyllin (PPP), a potent and selective inhibitor of IGF-1R, inhibits malignant cell growth with low or no toxicity on normal
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32

Waugh, Elspeth Margaret. "Molecular characterisation of canine lymphoma." Thesis, University of Glasgow, 2015. http://theses.gla.ac.uk/6496/.

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Lymphoma is the most common haematopoietic malignancy of dogs, but little is known about its aetiology and pathogenesis. Canine lymphoma is composed of a clinically heterogeneous group of tumours, as in human non-Hodgkin lymphoma (hNHL), which shares many similarities with the canine disease. In humans, lymphoma is classified into many different subtypes, each with its own clinicopathological characteristics, prognosis, and in many cases, treatment regime. In dogs, diagnosis is often rudimentary, and many cases are not routinely or robustly subtyped. This has hampered efforts to develop accura
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33

Boerma, Evert-Jan. "Molecular definition of Burkitt lymphoma." [S.l. : [Groningen : s.n.] ; Groningen University Library] [Host], 2009. http://irs.ub.rug.nl/ppn/317.

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34

Soussain, Carole. "Etude du rôle des péricytes dans le développement des lésions du système nerveux central induites par la radiothérapie. Développement d'un modèle animal de lymphome cérébral appliqué aux essais thérapeutiques précliniques." Thesis, Paris 11, 2014. http://www.theses.fr/2014PA11T003.

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L’irradiation cérébrale thérapeutique comporte un risque de neurotoxicité tardive irréversible en partie lié à l’effet de l’irradiation sur le compartiment vasculaire cérébrale. Les péricytes et les communications entre les péricytes et les cellules endothéliales jouent un rôle majeur dans la stabilisation des vaisseaux, dans la formation et la régulation de la barrière hématoencéphalique et dans le contrôle du flux sanguin cérébral. Nous montrons, dans un modèle murin d’irradiation cérébrale, que les péricytes sont une cible précoce de l’irradiation cérébrale. Après irradiation, la morphologi
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35

Bachy, Emmanuel. "Stimulation bactérienne chronique et développement de lymphomes de type Natural Killer T-Cell (NKT) chez la souris." Thesis, Lyon 1, 2012. http://www.theses.fr/2012LYO10261.

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Le lien entre infection et lymphomagénèse est établi depuis plusieurs décennies. Notamment, deux types de mécanismes sont décrits : le premier, qualifié de direct et largement établi, fait intervenir un pathogène capable d'intégrer un ou plusieurs oncogènes dans la cellule et d'aboutir à sa transformation (par exemple le virus HTLV-1 ou le virus EBV) tandis que le second, qualifié d'indirect et mal connu, aboutit à la transformation cellulaire par une stimulation antigénique répétée du lymphocyte, le plus souvent dans un contexte inflammatoire, par un pathogène particulier (comme Helicobacter
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36

Cuceu, Corina. "Telomere Dysfunction And Chromosomal Instability In Hodgkin Lymphoma." Thesis, Université Paris-Saclay (ComUE), 2015. http://www.theses.fr/2015SACLS210/document.

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Le lymphome de Hodgkin est caractérisé, d’un point de vue histologique, par la présence de rares cellules tumorales nommées cellules de Reed et Sternberg, au sein d’un infiltrat cellulaire polymorphe, inflammatoire et réactionnel. Cette dernière résulte de la transformation tumorale de cellules lymphocytaires B qui acquièrent des propriétés d’échappement au système immun, de prolifération, de résistance à l’apoptose et une instabilité chromosomique. Néanmoins, la rareté des cellules tumorales, impliquant des problèmes techniques mais aussi de caractérisation des évènements primaires dans l’ini
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37

Fatima, Zainab, Haroon Rahman, Sonia Kumari Oad, Elnora Spradling, and Devapiran Jaishankar. "Lymphoma at First Sight: A Rare Case of Mantle Cell Lymphoma Presenting as Isolated Periorbital Swelling." Digital Commons @ East Tennessee State University, 2020. https://dc.etsu.edu/asrf/2020/presentations/26.

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Mantle cell lymphoma (MCL) represents a heterogenous subtype of non-Hodgkin lymphoma (NHL), which can present in three distinct clinicopathologic variants: indolent type MCL, classic type MCL and blastoid type MCL. Despite the different variations, MCL, in general, is almost always associated with advanced-stage disease at diagnosis, with a strong predilection for significant extranodal involvement, usually to the bone marrow, CNS, peripheral blood and the gastrointestinal tract. However, the literature review reveals ocular involvement is a more rarely described extranodal site of involvement
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38

Yamamoto, Ryo. "Significance of PD-1/PD-1 ligand signaling in Hodgkin lymphoma and anaplastic large cell lymphoma." Kyoto University, 2010. http://hdl.handle.net/2433/97949.

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39

Bayne, Michael Christopher. "Fractionated radioimmunotherapy of non-Hodgkin's lymphoma." Thesis, University of Southampton, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.431950.

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40

Yip, Bon-ham. "Immunoglobulin gene translocations in gastric lymphoma." Click to view the E-thesis via HKUTO, 2006. http://sunzi.lib.hku.hk/hkuto/record/B37345321.

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41

Tucker, Catherine Amanda. "Targeted therapies in mantle cell lymphoma." Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/922.

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Mantle cell lymphoma (MCL) is characterized by the presence of the t(11 ;14)(g13 ;g32) translocation which results in cyclin Dl over-expression. MCL is one of the most difficult lymphoproliferative disorders to manage with a median survival rate of 43 months from diagnosis. The poor prognosis associated with MCL is due in large part to its late classification as a separate clinical entity leading to a dearth in available pre-clinical models. The specific objectives of the research described in this thesis were (1) to establish MCL preclinical models of disease and (2) to evaluate deregulated c
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42

Yip, Bon-ham, and 葉邦瀚. "Immunoglobulin gene translocations in gastric lymphoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B37345321.

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43

Starczynski, Jane Louise. "Diagnosis and monitoring of indolent lymphoma." Thesis, University of Warwick, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.425989.

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44

Wilson, Gillian Anne. "The genetic aetiology of lymphoplasmacytic lymphoma." Thesis, University of Sheffield, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.434569.

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45

Jennings, Nicola. "Therapeutic DNA vaccination in follicular lymphoma." Thesis, Open University, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.437323.

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46

Bley, Linda D. "Nutritional factors and non-Hodgkin's Lymphoma /." Thesis, Connect to this title online; UW restricted, 1996. http://hdl.handle.net/1773/10864.

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47

FRANCESCHETTI, Silvia. "Histologic transformation in marginal zone lymphoma." Doctoral thesis, Università del Piemonte Orientale, 2014. http://hdl.handle.net/11579/45359.

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Information concerning histologic transformation (HT) of marginal zone lymphomas (MZL) into aggressive entities is scant. We retrospectively analyzed the clinical variables at diagnosis and outcome, with special reference to HT, in a population of consecutive patients (pts) with confirmed diagnosis of MZL, including extranodal MZL (MALT lymphoma), splenic MZL (SMZL) and nodal MZL (NMZL). The database of the Hematology Division of the Amedeo Avogadro University of Eastern Piedmont (Novara) and of the Oncology Institute of Southern Switzerland (IOSI, Bellinzona) includes 373 cases of MZL
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48

Tawadros, Fady, Sakshi Singal, Maria Zayko, and Devapiran Jaishankar. "Mucosal Associated Lymphoid tissue of the Skin, A Common Entity in a Rare Location." Digital Commons @ East Tennessee State University, 2019. https://dc.etsu.edu/asrf/2019/schedule/55.

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Marginal zone (MZ) lymphomas (MZLs) represent a group of lymphomas originating from B lymphocytes of the “marginal zone” which is the external part of the secondary lymphoid follicles. The WHO classifies MZL into 3 entities; extranodal MZL, splenic MZL and nodal MZL. Extranodal marginal zone lymphoma (EMZL) can arise in different tissues, including the stomach, salivary gland, lung, small bowel, thyroid, ocular adnexa and skin. We present a 25 years old female with a history of angioedema and chronic cutaneous eczema who developed an unusual EMZL. Patient presented with a history of rapidly en
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49

Pham-Ledard, Anne Liên. "Oncogénèse des lymphomes cutanés B." Thesis, Bordeaux, 2014. http://www.theses.fr/2014BORD0319/document.

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Les lymphomes cutanés primitifs B comprennent 2 formes indolentes (lymphomes des centres folliculaires et de la zone marginale) et une forme clinique agressive, le lymphome B diffus à grandes cellules de type jambe. Si le lymphome des centres folliculaires ne présente le plus souvent pas la translocation t(14;18) à l'origine d'une dérégulation de BCL2 caractéristique des lymphomes folliculaires ganglionnaires, elle peut être identifiée en FISH dans 8,7% des cas et représenter un risque d'extension extra-cutanée. En revanche, l'étude de l'oncogenèse des lymphomes B de type jambe révèle des méca
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50

Ulvé, Ronan. "Caractérisation moléculaire et cellulaire des lymphomes canins : modèles précliniques prédictifs des lymphomes homologues humains." Thesis, Rennes 1, 2016. http://www.theses.fr/2016REN1B045.

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Les lymphomes sont des cancers parmi les plus fréquents chez l’Homme et le chien. Ils présentent de fortes homologies du point de vue clinique, histologique et de la réponse aux traitements. Dans le contexte actuel, les méthodes de séquençage de nouvelles générations (NGS) permettent l’identification de nombreuses altérations génétiques nécessaires pour le diagnostic, le pronostic et le développement de thérapies ciblées. Pourtant, le développement de nouvelles molécules rencontre une forte proportion d’échec lors des études cliniques. Ce constat est en partie dû à l’utilisation de modèles non
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